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<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NSP0</accession>
    <name>A0A0G4NSP0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S001g000075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamine synthetase family.</text>
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    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS catalytic" evidence="2">
        <location>
            <begin position="14"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL17115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="71" mass="8672" checksum="2A070CC17CF4F1E9" modified="2015-09-16" version="1">MDESIRVQYGMDKGMPGTFKEALDCLKMDFAVKTWMAEDLLKWFISVKDKEVEEFRKMTDEQRRFRFLDYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NT74</accession>
    <name>A0A0G4NT74_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S001g000213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NT74"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL17253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="106" mass="12106" checksum="4D1441BEBC4C6AD5" modified="2015-09-16" version="1">MELLINLNAVQQLDPEGAHMAEQIHNLGHMKDEDVGWYSDLAASKYTECNPWMDDYDNAHASKKERELKAKGLNRQNKNGFLQKVLNSLLLHYVPNLHSLLQAASY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NTV7</accession>
    <name>A0A0G4NTV7_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pyrroline-5-carboxylate reductase</fullName>
            <ecNumber evidence="9">1.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S001g000359</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 9">
            <text>L-proline + NADP(+) = (S)-1-pyrroline-5-carboxylate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="9"/>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NTV7"/>
    <dbReference type="STRING" id="1429867.A0A0G4NTV7"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000001">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000105">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053790">
        <property type="entry name" value="P5CR-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF0">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 9" id="KW-0521">NADP</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 9" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="10">
        <location>
            <begin position="8"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="11">
        <location>
            <begin position="173"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="72"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL17399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="284" mass="29500" checksum="A52F8E1516CB7A29" modified="2015-09-16" version="1">MPSIQESKLAFIGGGNMASAIIGGLLSKGVNKQNICVSEPWDVNREKIAALGVRTTTSNVEAGGDADLVIIAVKPQVTKAVCQELGGAWSPRATLPVVVSIAAGITLDSLKEWLTTSDSRTAHTVRVMPNTPALVGEGASGAFASTDVTPAEKELVNSMLASVSKATEWVDREDLLDVVTGLSGSGPAYFFAMVEHLVASATALGLPEEQATRLATQTCLGAGKMLVESSDGPSQLRKNVTSPNGTTYAALQTFESLNFKEIVDKSVQAATARSAELGNPSTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NTW9</accession>
    <name>A0A0G4NTW9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamine amidotransferase class-I, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S001g000480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="entry name" value="ChyE-like"/>
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        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF5">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="Glutamine amidotransferase" evidence="1">
        <location>
            <begin position="33"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL17520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="256" mass="28882" checksum="8732EFD4B60C23AD" modified="2015-09-16" version="1">MSPSIRIHVAILVCDTPIQPVLRKYGDYFTIFQALLRQAFKDLEISEKFKDITVEFSEHQMVDNNRFLDLDKVDAVLLTGSKHDAWAEDQWIRNLTSNIRETVLTHKKPVVGICFGHQILARALGARVGRSEAGWEISVEKLTLTEAGKKLFGKDTLSIQQMHRDIVFDTPIDCANLATSPKCEVQGLYLPKQVLSVQGHPEYNEGIMSCLLEARHDNGIFGDELYKDGLSRMGESHDGWLIAKTIARFIVDAKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NU79</accession>
    <name>A0A0G4NU79_PENC3</name>
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        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S001g000601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NU79"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL17641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="33" mass="3536" checksum="94CD4001B74CB0B3" modified="2015-09-16" version="1">MGFPDKPPGVVGSVPRYFSPPFIRPVQMTNGCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NUF3</accession>
    <name>A0A0G4NUF3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome c oxidase, subunit VIb</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S001g000564</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome c oxidase subunit 6B family.</text>
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        <property type="protein sequence ID" value="CRL17604.1"/>
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    <dbReference type="STRING" id="1429867.A0A0G4NUF3"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome c oxidase assembly factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="COA6_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47677">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47677:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL17604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="117" mass="13454" checksum="59D0972EA497AB73" modified="2015-09-16" version="1">MGWNPWSSGDSNKNAASDGGRIAPDRTSRARCWEGRDSFFACLDKNDILDGIKDDKKARQKCANEVAEFEAACSQSWVKYFKEKRVMEFNRDKTIERIQKEDAAKVKELKEKGWNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NUF8</accession>
    <name>A0A0G4NUF8_PENC3</name>
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        <submittedName>
            <fullName evidence="5">Cyclin-like F-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S001g000655</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NUF8"/>
    <dbReference type="STRING" id="1429867.A0A0G4NUF8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="135"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="207"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="270"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="452"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL17695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="840" mass="93727" checksum="9E2ADE0F631FF2FB" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NUG1</accession>
    <name>A0A0G4NUG1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S001g000660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NUG1"/>
    <dbReference type="STRING" id="1429867.A0A0G4NUG1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051604">
        <property type="entry name" value="Ergot_Alk_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162:SF1">
        <property type="entry name" value="PRESTALK A DIFFERENTIATION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="2"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL17700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="305" mass="32959" checksum="867F33DA79639C88" modified="2015-09-16" version="1">MSSVIVFGPTGGVASVAALTAREHGAKVFLAMRDTQKQIPGLSTKEEQEGGFERIQADLTNPDSVAAAIKASGAKRAFTYVSFGSADHMRSTLTAMKSAGIEFVVFLSSYTIAGEPKDVTPAELIPYIHAQVELSLDEVFGPENYVALRPGGFVTNLLLFKEGIEAGEVKIWAPGFQFDCITPGDMGRVGGTILVHGPKNDQKKVYLYGPRLITQGDAIVAIGKIIGKDVKLTTINKEEALDQYLAHGMHKPLAEYMVEKSASTSNELTDRACYKTGVENVELYTGKPSTKFEDWVEANKELFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NVD2</accession>
    <name>A0A0G4NVD2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S001g000970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL18010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NVD2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL18010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="75" mass="8203" checksum="C314961932392F82" modified="2015-09-16" version="1">MKDKAGLTWIAYIQLNNESLVHRIASHSMSGPETNFRTGVQARGGKCLVTGLIVLSRFAQGTRLARSFARVPSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NVT5</accession>
    <name>A0A0G4NVT5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioesterase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S002g000055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NVT5"/>
    <dbReference type="STRING" id="1429867.A0A0G4NVT5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF1">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="1">
        <location>
            <begin position="167"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL18185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="265" mass="29808" checksum="3B084140EC29673A" modified="2015-09-16" version="1">MIHYRNILQSALRQSSIQTRSFWRPAVRSVSTAAQPNTSREPSRWMRRLIYTGIFGTLGVSAGKWLDNKIAAPPAPGSLEDQLEIQEIQRVFDIGLPIVQELRRNPDYVEKDVYENFSDKHKTHRLTSGPLAGSRGLGLQNVFWNDKEKKIVSVVFLGPGLEGWPTMVHGGALGTVIDENLGRAAIRHFPARTGVTANLELNYRAPVHSDNFYTLHTTLDQERSTETKAYAMCEVRDMAGRLCVEATGLFVVPKRLKLNKVGEYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NW41</accession>
    <name>A0A0G4NW41_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S002g000150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NW41"/>
    <dbReference type="STRING" id="1429867.A0A0G4NW41"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052356">
        <property type="entry name" value="Thiol_S-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036:SF1">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005194963" evidence="1">
        <location>
            <begin position="33"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase type 11" evidence="2">
        <location>
            <begin position="84"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL18280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="260" mass="28929" checksum="70F8671A5D3A5A4B" modified="2015-09-16" version="1">MAPKPGRLASILRPWGLIWLSVCLHWEALTQAVRRDGLAALSRPQQIRDAASAKLLSIASDGFIAYENTTIVPSLVRAAGGIVLELGPGPGNQIHRYDTSIVKHIYGIEPNPHFKDDINARLDKYDLQEKYKVIVCGVEDSDVLREEGITEGSLDAVLCIQVLCAVKDPKSVMKEVWKLLKPGGKFIFWEHGCSRDRLTTVAQACWNPAWSTFVGCDLTRNVLADILNSGEWENPHEIEEPEEPFSLLPRIQGVLVKKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NX29</accession>
    <name>A0A0G4NX29_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S002g000476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18606.1"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="333" mass="38416" checksum="EF9364CE620E6B44" modified="2015-09-16" version="1">MSLTRSHSQWPRGIPSFIRRHEEPVARKNFDAASRAWRHFVREQWVGGDGADQQKRALIERWATADQQFRDSYQSRALEDEPSFFEGPELTDKTFGANNVQSSCMVYFCTTELTPEKEALLAKCILGLFPWEDGWDFLADEMIVFVPPKDNKGNVLETFKFYQSVARPNFLDMYMALDGTVLFRDCSPKLIIDDRTLETGLGLWVDFATNGIYEIARRGQIMMEEFAYFYREIGPGNRVPIDQALNYIEDREIYIDRDEDADPREILEDEPVDMRRPLVEIYKGNEVDLVDDYAPGFREAEEQGDGLAIGFDLERILANDGNPLIVRDHGSDH</sequence>
</entry>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Silar P."/>
                <person name="Lacoste S."/>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="3HC_DH_C"/>
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    </dbReference>
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        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF10">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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    </dbReference>
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            <end position="593"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL18615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="608" mass="67281" checksum="934258F06F0F68B8" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXL5</accession>
    <name>A0A0G4NXL5_PENC3</name>
    <protein>
        <submittedName>
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        </submittedName>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
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                <person name="Bensimon A."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
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    </dbReference>
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            <end position="20"/>
        </location>
    </feature>
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        <location>
            <begin position="29"/>
            <end position="70"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL18810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="70" mass="7775" checksum="8FD66D257EA85D5F" modified="2015-09-16" version="1">MNLEHVGLREHNAPATNIRPHVRYKRPIAEDSKHADPDTQAMNPQETPGCSLMHGKPTAPGPSALSVRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXS2</accession>
    <name>A0A0G4NXS2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
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    </gene>
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
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    </dbReference>
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            <end position="45"/>
        </location>
    </feature>
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        <location>
            <begin position="132"/>
            <end position="228"/>
        </location>
    </feature>
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        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
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        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
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            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL18846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="421" mass="46511" checksum="FE696676BC601097" modified="2015-09-16" version="1">MGIPMWREPSKAEASKSALEKDPSATARSSIRRGPSRHTSSRVRRADILASFHSQIIDELRRGTVEPRRVPRFSFIPPNGAMENAVALEQAEREALVWAQSRAASAPRQTEAANQLFRNHRDQALTELLGRMDGQPRNTQASPSLTPNFAPARAYHTSASSTPPDSGVRLPPMRERYNSDRASNTSFPPEIPEYRSNNNTQPRSTRDPVVDGLGDRQRSPSPDAERETDAWETLLSTITPDATLPSTDTSFTSTSAAAPDISRNARPRSTVNLTQPMTADAARAHFGLDPYPDQLNPCDFSSSDDEDAPSTFHEFMGRVVRRPDQNSTMSNHPPVPVPVIIPASVLALSDGRRQNPSLSDRHHQNDDLHHMQVILDRLARREDIPDDWWAAAGLARTLDRGLSASMDSTDTEGASHTNRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXV8</accession>
    <name>A0A0G4NXV8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
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    </gene>
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        <lineage>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL18886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="99" mass="10946" checksum="4F59DB7DCDE8E998" modified="2015-09-16" version="1">MQLSDGLLYVPKTPGSSNGKRGWHFGLPIDDTPLLPLLHRSGTNIPSIYDTSRLMPYEPTLAGGCSLSELDTPRTRKRVRGAQYPRSSLRIPLEILRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYI1</accession>
    <name>A0A0G4NYI1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cyclic peptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S002g001000</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="CRL19130.1"/>
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    </dbReference>
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        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ABC multidrug transporter Mdr1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
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    </dbReference>
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        <property type="entry name" value="ABC1_TM_sf"/>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="3" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="93"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="765"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="809"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="890"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="914"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="998"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1028"/>
            <end position="1051"/>
        </location>
    </feature>
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        <location>
            <begin position="97"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="422"/>
            <end position="667"/>
        </location>
    </feature>
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        <location>
            <begin position="768"/>
            <end position="1057"/>
        </location>
    </feature>
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            <end position="1330"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CRL19130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1337" mass="146458" checksum="D887D6260B2A607B" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYJ8</accession>
    <name>A0A0G4NYJ8_PENC3</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
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                <person name="Goarin A."/>
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                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
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        </subcellularLocation>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
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            <dbReference type="ARBA" id="ARBA00005287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL19059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="148" mass="17161" checksum="3DA5F42CDBD0E95D" modified="2015-09-16" version="1">MPPIRTARNRKPPPAGFDDLEDTLLEFSNKMKDAENASHEGKKKYEVLWPIFQISHQRSRYIYELYYEKEAISKELYDFLLKNKYADANLIAKWKKQGYEKLCCLRCVQTKETNFNSTCICRVPKAQLKEDQTIQCVSCGCNGCGSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
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    <name>A0A0G4NYQ1_PENC3</name>
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        <submittedName>
            <fullName evidence="7">Str. FM013</fullName>
        </submittedName>
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    <organism evidence="7 8">
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
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                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Single-pass membrane protein</topology>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="JMTM_APP_like"/>
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        </source>
    </evidence>
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</entry>
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    </organism>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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                <person name="Debuchy R."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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            <begin position="18"/>
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        </location>
    </feature>
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            <end position="208"/>
        </location>
    </feature>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="964" mass="104714" checksum="8D07CAD8A4CBA02C" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
    </protein>
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    </gene>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
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        </reaction>
    </comment>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </evidence>
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        </source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P134</accession>
    <name>A0A0G4P134_PENC3</name>
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        <submittedName>
            <fullName evidence="12">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
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        <name evidence="12" type="ORF">PCAMFM013_S003g000785</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Dupont J."/>
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                <person name="Abraham A.L."/>
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                <person name="Lacoste S."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1429867.A0A0G4P134"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P209</accession>
    <name>A0A0G4P209_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">P-type Na(+) transporter</fullName>
            <ecNumber evidence="19">7.2.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">PCAMFM013_S004g000274</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>K(+)(in) + ATP + H2O = K(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75815"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>Na(+)(in) + ATP + H2O = Na(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:14634"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.3" evidence="19"/>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P209"/>
    <dbReference type="STRING" id="1429867.A0A0G4P209"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008554">
        <property type="term" value="F:P-type sodium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000015">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000047">
        <property type="entry name" value="Sodium P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006414">
        <property type="entry name" value="P-type_ATPase_IID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01523">
        <property type="entry name" value="ATPase-IID_K-Na"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="17" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="359"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="791"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="828"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="875"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="916"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="969"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="999"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="24">
        <location>
            <begin position="66"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00035017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00035029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="CRL20334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1066" mass="115625" checksum="B2CBD96FF5452A99" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3K1</accession>
    <name>A0A0G4P3K1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S005g000048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL20884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P3K1"/>
    <dbReference type="STRING" id="1429867.A0A0G4P3K1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL20884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="213" mass="24686" checksum="7CA1D34378F8F5E2" modified="2015-09-16" version="1">MITNRPATLADIPQVRDINHWYIVNSCSTFATTPPPISHYEDILRDLMRRNLPFYVIVSDTRKTPDGSDLILGYAYLSPFRGHLLSYAPTVELSIFMRYDQQQYGYGTIILRKLLRLVQEGEIEHRCEERVGDIPRIGFGSSMGVMKTSLVRNVIAIIPYDTEAPEDGERLRQWCMKWGFIEKGQLENVGRKMGHWIDTVYLQWTMPEEADIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3U4</accession>
    <name>A0A0G4P3U4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S005g000128</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL20964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P3U4"/>
    <dbReference type="STRING" id="1429867.A0A0G4P3U4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF230">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL20964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="478" mass="54686" checksum="91F7363A1521D10D" modified="2015-09-16" version="1">MKIIWTVYFHPLRNLPGPKVWIAFPISRFIALSQGQLDAKMRSFHEQYGEVVRFGPNEVSFITAQAWKDIYGHGHRQLPKVLHSTSNPSDIVSANDADHSRLRRSLAHAFSAKGLQSQEPIITKYVDLLIGKLKVIAASSNPEADMVKWYNLTTFDILGDLAFGESFGGLESSEYHYWVSTIFQAIRGMSLVQFKDAYPLPFKVLSPFVGSKRLMNARRRQIEFSRATVQKRLQLQGHRECTDFIGSMLRQRGEPRKEITDEELEANSNVLVIAGSETTATLLSGVTYWLLRTPHAMEEITREIRSTMKTENDITISSTANLPYMLACLKEALRMYPPAPSGQQRMTLGPEPTQISGYVMPPNTKVSVHQYAAYRSSINFHAPDKFIPERWLENTRANQYSPFYNDNQDVLQPFSVGPRNCIGRELAYSELRVILGRILWSFDLELHERSVKWDIQRSYLLWEKPPLICKLKRSNKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P449</accession>
    <name>A0A0G4P449_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoside phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S005g000269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P449"/>
    <dbReference type="STRING" id="1429867.A0A0G4P449"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL21105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="486" mass="54200" checksum="F24CF477FFCCCB0B" modified="2015-09-16" version="1">MAAKNHDDYTVGWICALPLEMAAAQVLLDEVHEDLPVQANDHNAYTLGSIGKHNVVIACLPYGQYGIASATSVAVQLLSSFRSIRFGLMVGIGGGVPNEDADIRLGDVVVSKPTSTHGGVVQFDYGKALNGGEFQRTGMLSHPPQILLTALSKLQANHITGRSRFMDFLAEIERKIPKQSSPLARPTQEDRLYRADHNHVDASSKTCDDCDETKTVSRPSRDSNQPMVHYGLIASSNQVVKDSQLRDQLGRELDAYCLEMEAAGLMNNYPCLVIRGICDYADSHKNKEWQGYAATVAAAYAKELLSVTPVIRIDQTRTVEDTLFNPGVTTASHSKDPSRPVTPNPFQANPPMVINQSELGGIYLGTIRGEEIIPRLIQDPAFWRAEINALIRQLLLIHPQWWVERTQQTEKTMNDFFARNRLTFRVNILQRRTGRPDYSGHDRQYLDSLFHHNLGWLNGFSVEEGVPEINLAILNLWSILEFLDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P4E0</accession>
    <name>A0A0G4P4E0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S005g000333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P4E0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL21169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="63" mass="7060" checksum="3BE8219953B2D26B" modified="2015-09-16" version="1">MDFIVALPTTPEGSDALLTMADKFSKQNGFVMGKTTWEGADWSKSVVTFWMTAVINQKYRPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6A5</accession>
    <name>A0A0G4P6A5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S006g000382</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P6A5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
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    </dbReference>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF12">
        <property type="entry name" value="TRANSCRIPTION FACTOR ASQA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="29"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="101"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL22445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="755" mass="84695" checksum="41F524A1BF304F4F" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P8B0</accession>
    <name>A0A0G4P8B0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S007g000549</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C56 family. HSP31-like subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="1"/>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P8B0"/>
    <dbReference type="STRING" id="1429867.A0A0G4P8B0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF11">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="6">
        <location>
            <begin position="28"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL22568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="237" mass="25429" checksum="408ADF8E166FDFA5" modified="2015-09-16" version="1">MTPARKALIAITSAKATLNNETTGLFITEALHPYNVLVAAGFEVDLASETGTYTADWLSQTPDFLNGDDLTIWNDVNSDFRKKLDNMPKAADLDASQYGIFYASAGHAALIDYPTATSLQKVAEQVWASGGVVASVCHGPAIFANILDRGTGRPVIQGRRLTGFTTEAENTMGIIGDLKSWNVELCEELAARLGAKYERSVGIWDDFHVVDGRLVTGQNPASATSTAKAAVEVFDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P8H8</accession>
    <name>A0A0G4P8H8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S008g000036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P8H8"/>
    <dbReference type="STRING" id="1429867.A0A0G4P8H8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL22607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="68" mass="7293" checksum="D547F0C1B9292D8A" modified="2015-09-16" version="1">MGSITSVPGQRLTATARDITSLLYLDNNNPAILRLALDVTQLLAVDAALKATRAHFGDSYYVDATNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P8K2</accession>
    <name>A0A0G4P8K2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GTP-binding protein, HSR1-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S008g000061</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P8K2"/>
    <dbReference type="STRING" id="1429867.A0A0G4P8K2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04938">
        <property type="entry name" value="TGS_Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01899">
        <property type="entry name" value="Ygr210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.470:FF:000001">
        <property type="entry name" value="GTP-binding protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000030">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013646">
        <property type="entry name" value="YGR210-like_G4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF1">
        <property type="entry name" value="OBG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08438">
        <property type="entry name" value="YGR210-like_G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="5"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL22632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="414" mass="45483" checksum="211380874ACF0AA2" modified="2015-09-16" version="1">MPRDPLIGLVGKPSSGKSTTLNSLTDATSKVGNFPFTTIDPQRAIGYLQIDCPCQRHNVSDRCQPNYGGCHEGRRSVPIELLDVAGLVPGAHQGRGLGNKFLDDLRHADALIHVVDVSGTTDAEGKATRGYDPSVDIEWLRSEIVRWVLGNLMERWGSIKRRHQALKANPVDTLQKQFAGYGSTHATVARFMDKLALKEPLEDWSNETVELVVNAFIDEKFPTVFALNKIDHPDADKNISKIAKMQDPQSIVLCSAISEVFLRKLAKQEYIKYVEGSEFVDTREDLIEMGDPDGGGLKEMDEKLKTRVENMKDMVLYRFGSTGVVQCLSRAAELLGLVPVFPVRNVATFNSGTGTAVFRDCVLVPKNSTVGDVARKVMGDVPINYVEGVGGTRVSEDDIVAVGKHDILSFKVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P8K7</accession>
    <name>A0A0G4P8K7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S008g000066</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P8K7"/>
    <dbReference type="STRING" id="1429867.A0A0G4P8K7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="8"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL22637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="521" mass="58430" checksum="2B9C72906DA6E089" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAL0</accession>
    <name>A0A0G4PAL0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">endo-polygalacturonase</fullName>
            <ecNumber evidence="3">3.2.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S009g000297</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(1,4-alpha-D-galacturonosyl)n+m + H2O = (1,4-alpha-D-galacturonosyl)n + (1,4-alpha-D-galacturonosyl)m.</text>
            <dbReference type="EC" id="3.2.1.15"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.15" evidence="3"/>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PAL0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PAL0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000002">
        <property type="entry name" value="Endopolygalacturonase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050434">
        <property type="entry name" value="Glycosyl_hydrlase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884:SF1">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 13 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195176" description="endo-polygalacturonase" evidence="14">
        <location>
            <begin position="21"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CRL23357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="376" mass="38057" checksum="071041D54EA63BE3" modified="2015-09-16" version="1">MASSLKLGLIALLGATAVNAAPAAEPVLGTSLLTSRASCTFSGSTGAAEAIKSKTSCSTITLSNVEVPAGTTLDLTGLKTGTTVIFEGTTTFGYKEWEGPLVSVSGTSITVQGATGAQLNGDGARWWDSKGTNGGKTKPKFFYAHSLTNSKIENIYIKNSPVQVFSINGAKELTLSGVTVDNADGDSNGGHNTDAFDVGSSDGVYITSPTVHNQDDCLAVNSGTNVHFTGAKCTGGHGISIGSVGGRSDNTVDGVTVEDCTISDSDNGVRIKTVYGATGAVKGVTYKDITLSGIAKYGIVIEQDYKNGSPTGSPTSGVPITDLTIDNVHGTVASGGVDTYILCASGACSDWTWSGVSITGGETSDKCEGIPTGASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAW9</accession>
    <name>A0A0G4PAW9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S009g000354</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PAW9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PAW9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048328">
        <property type="entry name" value="Dyp_perox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048327">
        <property type="entry name" value="Dyp_perox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006314">
        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01413">
        <property type="entry name" value="Dyp_perox_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF37">
        <property type="entry name" value="CLAVALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20628">
        <property type="entry name" value="Dyp_perox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04261">
        <property type="entry name" value="Dyp_perox_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="8">
        <location>
            <begin position="5"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL23414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="614" mass="66521" checksum="7A3E4FD5821CA9B9" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBG8</accession>
    <name>A0A0G4PBG8_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fructose-1,6-bisphosphatase</fullName>
            <ecNumber evidence="5">3.1.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">D-fructose-1,6-bisphosphate 1-phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCAMFM013_S010g000057</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the FBPase class 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="5"/>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PBG8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PBG8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005986">
        <property type="term" value="P:sucrose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00354">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000009">
        <property type="entry name" value="Fructose-1,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000001">
        <property type="entry name" value="Fructose-1,6-bisphosphatase class 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01855">
        <property type="entry name" value="FBPase_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044015">
        <property type="entry name" value="FBPase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000146">
        <property type="entry name" value="FBPase_class-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033391">
        <property type="entry name" value="FBPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028343">
        <property type="entry name" value="FBPtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020548">
        <property type="entry name" value="Fructose_bisphosphatase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556">
        <property type="entry name" value="FRUCTOSE-1,6-BISPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556:SF1">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00316">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18913">
        <property type="entry name" value="FBPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500210">
        <property type="entry name" value="FBPtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000904">
        <property type="entry name" value="FBPtase_SBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00115">
        <property type="entry name" value="F16BPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00124">
        <property type="entry name" value="FBPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class I N-terminal" evidence="14">
        <location>
            <begin position="18"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class 1 C-terminal" evidence="15">
        <location>
            <begin position="216"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CRL23619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="350" mass="38335" checksum="0195F6120954797D" modified="2015-09-16" version="1">MATAPPVGAENINTDIVTLSRFFTEEQIKHPEASGDFTLLCHALQFSFKSIAYYIRRASLINLTGLAGSSNITGDDQKKLDVIGNDIFISAMRGSGKCRIIVSEEEEEVIRFDEHPDARYAVVCDPIDGSSNLDAGVSVGTIFGIFQLPDEVLGPNKTVGPEDLLHPGTSLVASGFTMYGASAQLVITMRGGGVNGFTLENSLGEFILTHPNMKLPAARSIYSVNEGNSQYWDEWCNAYFHSLKYPENGGKPYSARYIGSMVADAYRTLLYGGIFAYPADSKSPKGKLRILYECAPMAMVFENAGGLAVNSRMERLMEVVPENIHDKSGVFLGSKDEVQKVIDMYNKYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBP1</accession>
    <name>A0A0G4PBP1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Restriction of telomere capping protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S010g000175</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
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        <text evidence="1">May be involved in a process influencing telomere capping.</text>
    </comment>
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        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
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        <subcellularLocation>
            <location evidence="2">Nucleus</location>
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    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RTC4 family.</text>
    </comment>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="RTC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028094">
        <property type="entry name" value="RTC4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391:SF1">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14474">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01312">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Restriction of telomere capping protein 4 C-terminal" evidence="9">
        <location>
            <begin position="445"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="171"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="302"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00015162"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="SMART" id="SM01312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL23737.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="581" mass="64987" checksum="AF6B950792CC95DA" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBV9</accession>
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        <name evidence="2" type="ORF">PCAMFM013_S010g000187</name>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="16"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL23749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="347" mass="37257" checksum="57DAB746E077201A" modified="2015-09-16" version="1">MSPSTMKQWVVEDKEHDFDGLVYKDAAVPKVGENEVLVKLQAASLNYRDLTIPKDLYPFALSLPVVPGSDGAGEVIEVGSKVVEFKKGDHVATLFNQGHQYGEIDTFAAGTGLGGVIDGALREYGVFNEQGLVKAPKNLDAREASTLPCAALTSWNALYGLKPLKPGQVVLVQGTGGVSMFGLQFAKAAGATVIATTSSAEKAEKLKKLGADHVINYKTEPNWGEAARKLTPDGAGVDHVIEVGGSGTLQQSFKCVKFEGIISVIGFLGGVDPKTQPTVLETLSNICTVRGVYVGSKALMRDMIRAIEANDIHPVVDEKVFSLDETREAYDYMWAQKHFGKLTIKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBY4</accession>
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        <submittedName>
            <fullName evidence="5">Str. FM013</fullName>
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    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S010g000237</name>
    </gene>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL23799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="613" mass="68085" checksum="F0F982157C827E95" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PC78</accession>
    <name>A0A0G4PC78_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATPase, AFG1-like</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="ORF">PCAMFM013_S010g000368</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
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        <property type="project" value="TreeGrafter"/>
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        </source>
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</entry>
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                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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                <person name="Giraud T."/>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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    </organism>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Dupont J."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL23957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="527" mass="58525" checksum="3937C1E4DA9C2D7D" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCM0</accession>
    <name>A0A0G4PCM0_PENC3</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <location>
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        </location>
    </feature>
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        <location>
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        <location>
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            <end position="362"/>
        </location>
    </feature>
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            <end position="413"/>
        </location>
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        <location>
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            <end position="584"/>
        </location>
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        <location>
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            <end position="752"/>
        </location>
    </feature>
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        <location>
            <begin position="765"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="992"/>
        </location>
    </feature>
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        <location>
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            <end position="275"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="401"/>
        </location>
    </feature>
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    </feature>
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        <location>
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            <end position="992"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL24071.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="992" mass="110089" checksum="3758FC81EA549A7B" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDG6</accession>
    <name>A0A0G4PDG6_PENC3</name>
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        <submittedName>
            <fullName evidence="5">Alkaline-phosphatase-like, core domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S011g000369</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PDG6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PDG6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004423">
        <property type="term" value="F:iduronate-2-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16150">
        <property type="entry name" value="sulfatase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45953">
        <property type="entry name" value="IDURONATE 2-SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45953:SF1">
        <property type="entry name" value="IDURONATE 2-SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="4">
        <location>
            <begin position="30"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL24375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="520" mass="59081" checksum="FA73187E9B11AEF9" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDI7</accession>
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            <fullName evidence="8">rRNA biogenesis protein RRP5</fullName>
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        <alternativeName>
            <fullName evidence="9">Ribosomal RNA-processing protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S011g000365</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the biogenesis of rRNA. Required for the formation of 18S and 5.8S rRNA.</text>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CRL24371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4PDI7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05702">
        <property type="entry name" value="S1_Rrp5_repeat_hs11_sc8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05703">
        <property type="entry name" value="S1_Rrp5_repeat_hs12_sc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05693">
        <property type="entry name" value="S1_Rrp5_repeat_hs1_sc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05697">
        <property type="entry name" value="S1_Rrp5_repeat_hs5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05698">
        <property type="entry name" value="S1_Rrp5_repeat_hs6_sc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04461">
        <property type="entry name" value="S1_Rrp5_repeat_hs8_sc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05706">
        <property type="entry name" value="S1_Rrp5_repeat_sc10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05708">
        <property type="entry name" value="S1_Rrp5_repeat_sc12"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="protein RRP5 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000467">
        <property type="entry name" value="Putative rRNA biogenesis protein RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000155">
        <property type="entry name" value="rRNA biogenesis protein RRP5"/>
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    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000159">
        <property type="entry name" value="rRNA biogenesis protein rrp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000196">
        <property type="entry name" value="rRNA biogenesis protein RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000266">
        <property type="entry name" value="rRNA biogenesis protein rrp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000278">
        <property type="entry name" value="rRNA biogenesis protein rrp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000279">
        <property type="entry name" value="rRNA biogenesis protein rrp5"/>
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    </dbReference>
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        <property type="entry name" value="rRNA biogenesis protein RRP5, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleic acid-binding proteins"/>
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    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
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        <property type="entry name" value="Rrp5"/>
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        <property type="entry name" value="Rrp5_OB_4th"/>
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        <property type="entry name" value="Rrp5_S1"/>
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        <property type="entry name" value="S1_domain"/>
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    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 11 PRE-RRNA PROCESSING PROTEIN RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270:SF10">
        <property type="entry name" value="PROTEIN RRP5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24685">
        <property type="entry name" value="OB_RRP5_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23459">
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="6"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TPR-like"/>
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        <property type="match status" value="11"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
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        <location>
            <begin position="162"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="279"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="467"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="559"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="653"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="837"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="943"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="1051"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="1136"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="1230"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="1319"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1392"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="106"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1396"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1418"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1501"/>
            <end position="1511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00055575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00076674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL24371.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1805" mass="198976" checksum="4B60D4870D3FA61B" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDW8</accession>
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            <fullName evidence="7">Bicupin, oxalate decarboxylase/oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S012g000101</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 manganese ions per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033609">
        <property type="term" value="P:oxalate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20305">
        <property type="entry name" value="cupin_OxDC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20304">
        <property type="entry name" value="cupin_OxDC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017774">
        <property type="entry name" value="Bicupin_oxalate_deCO2ase/Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051610">
        <property type="entry name" value="GPI/OXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03404">
        <property type="entry name" value="bicupin_oxalic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848">
        <property type="entry name" value="OXALATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848:SF9">
        <property type="entry name" value="SLL1358 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195379" evidence="5">
        <location>
            <begin position="19"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="6">
        <location>
            <begin position="116"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="6">
        <location>
            <begin position="293"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="40"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
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        <location>
            <position position="340"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29035"/>
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        </ligand>
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    <feature type="binding site" evidence="3">
        <location>
            <position position="345"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
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    </feature>
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        <location>
            <position position="384"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL24492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="454" mass="51478" checksum="CAB7CAC0C2331009" modified="2015-09-16" version="1">MQITHLLLNLACLQATWAIPAPDHSLQKLLQVPAGHPAEWLGQQPISRHPPFSPGHRDPYDHKVDSVGDERQPLPFRNGDGTTVMGPRNRDRERQNPDLVRPPSTDHGSMPNMRWSFADSHIRIEEGGWTRQTTIRELPTSRELAGVNMRLDQGVIRELHWHTEAEWAYVLAGKVRVTALDLEGATFMDDLEAGDLWYFPAGHPHSLQGLGENGTEFLLIFDDGNFSEESTFVLTDWLAHTPKAVLAENFRMSPKQFDNIPTSEKYIFQGSNPGSIDQEKPRTFKKSKINFTHHMHAQEPLETSGGLVRITDSTNFPISKTVAAAHLEIAPGALREMHWHPNADEWTYFKKGRARVTIFAAEGNARTFNYMAGDVGIVPRNMGHFVENLSDDEPLEVLEIFRADRFRDFSLFQWLGSSPRRMIAENIFPDDPKAAAEFLRKIEDAEKDPIRDTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PE72</accession>
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    <protein>
        <submittedName>
            <fullName evidence="9">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S012g000232</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793145">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PE72"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="XlnR/Xlr1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663:SF2">
        <property type="entry name" value="ARABINOLYTIC TRANSCRIPTIONAL ACTIVATOR ARAR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="36"/>
            <end position="67"/>
        </location>
    </feature>
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            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="396"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL24622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="786" mass="89833" checksum="FDCB135A9B48BB9A" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PEE9</accession>
    <name>A0A0G4PEE9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily, general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S012g000251</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793145">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PEE9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MFS"/>
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        <property type="entry name" value="MFS_dom"/>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="509"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="88"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL24641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="569" mass="61528" checksum="7722A89718EDD6A3" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-11-27" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PEZ6</accession>
    <name>A0A0G4PEZ6_PENC3</name>
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        <submittedName>
            <fullName evidence="6">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S013g000119</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL24876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1429867.A0A0G4PEZ6"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016787">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF6">
        <property type="entry name" value="AMIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="97"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="3">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="248"/>
            <end position="251"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL24876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="586" mass="63288" checksum="F43E9AB9B3B890F3" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGC4</accession>
    <name>A0A0G4PGC4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">RNA cytidine acetyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">18S rRNA cytosine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">NAT10</name>
        <name evidence="18" type="ORF">PCAMFM013_S014g000233</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in 18S rRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51424"/>
            <dbReference type="Rhea" id="RHEA-COMP:13575"/>
            <dbReference type="Rhea" id="RHEA-COMP:13576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a cytidine in tRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in tRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53876"/>
            <dbReference type="Rhea" id="RHEA-COMP:13670"/>
            <dbReference type="Rhea" id="RHEA-COMP:13671"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with TAN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
            <location evidence="1 11">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="11"/>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PGC4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PGC4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990883">
        <property type="term" value="F:18S rRNA cytidine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051392">
        <property type="term" value="F:tRNA cytidine N4-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904812">
        <property type="term" value="P:rRNA acetylation involved in maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051391">
        <property type="term" value="P:tRNA acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11040:FF:000002">
        <property type="entry name" value="RNA cytidine acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002218">
        <property type="entry name" value="tRNA(Met) cytidine acetyltransferase TmcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03211">
        <property type="entry name" value="RNA_acetyltr_Nat10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033688">
        <property type="entry name" value="NAT10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="TcmA/NAT10_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA/NAT10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027992">
        <property type="entry name" value="tRNA_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="N-ACETYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925:SF5">
        <property type="entry name" value="RNA CYTIDINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="NAT10_TcmA_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="TmcA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13725">
        <property type="entry name" value="tRNA_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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            <end position="767"/>
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    </evidence>
    <sequence length="1035" mass="115830" checksum="FE8478806FC9FE81" modified="2015-09-16" version="1"> </sequence>
</entry>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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            <end position="109"/>
        </location>
    </feature>
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        <location>
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    </feature>
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        </location>
    </feature>
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            <dbReference type="Pfam" id="PF05486"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL25798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="168" mass="17485" checksum="EB419784401E381B" modified="2015-09-16" version="1">MPYLPTSQAYLEQSAQLLQAYPDTTRIVTKYSFPTNRRGNIIRAHKSQVRKDAAKATDAPSTTPAQPPTAIATLTLKTFNPTTGICLHYRTNKAQEVSRLITSLGKLAAGADAAGLGLSAAVPAAGADVEMVDAPAPVEEVTPAAGKAQGQSQGQSAKGKKKGGKGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PIE9</accession>
    <name>A0A0G4PIE9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aromatic-ring hydroxylase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S017g000173</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793150">
        <property type="protein sequence ID" value="CRL26190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PIE9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PIE9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="10"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL26190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="427" mass="47538" checksum="D28F3FC2F6B493EE" modified="2015-09-16" version="1">MANSNTTPKLRVVIIGAGPAGLGAAIEFAKLPFVDLKIYEQARELREVGTGISLQRNTWRLLDAFGVLENIDPSDFFRSADGHSVQHRNGRTGELLLSNGQKDTPPRHKHARALRTVLQRGLLDGVDASLLRLSSRLVEIVELPSGTLSLRFEDGHTDEADLLVGADGVRSVVRSFAFPDHRIGYTGRTAYRALVDADKILRIPNFPDAVTFWHGPKDWVYTCNLNNNIYEVTTMAEVSGEIAKVSWGEDATLEELRKPYKEFAPIVQAVLDEVKEVKRFALFAGPRLSTVISRGSIALIGDASHPLSGAFGAGAGFALEDVFVLTQSVKWAYERDLPVGQGLQLFDNVRSPHYERLYGILDEFAKSDATIEVPIPFDDAVAKTVSDKWNEDHHWLYHYDVQEVWKEAYKAENVRARDNAEKLSSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PIG4</accession>
    <name>A0A0G4PIG4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial DNA polymerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PCAMFM013_S017g000107</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Involved in the replication of mitochondrial DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="HG793150">
        <property type="protein sequence ID" value="CRL26124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PIG4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PIG4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005760">
        <property type="term" value="C:gamma DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08641">
        <property type="entry name" value="DNA_pol_gammaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000035">
        <property type="entry name" value="DNA polymerase gamma, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.390:FF:000003">
        <property type="entry name" value="DNA polymerase gamma, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.390:FF:000006">
        <property type="entry name" value="DNA polymerase gamma, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019760">
        <property type="entry name" value="DNA-dir_DNA_pol_A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002297">
        <property type="entry name" value="DNA-dir_DNA_pol_A_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041336">
        <property type="entry name" value="DNApol_Exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047580">
        <property type="entry name" value="POLG_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267:SF0">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18136">
        <property type="entry name" value="DNApol_Exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00867">
        <property type="entry name" value="DNAPOLG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00447">
        <property type="entry name" value="DNA_POLYMERASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family A palm" evidence="16">
        <location>
            <begin position="700"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="482"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1065"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1068"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="1135"/>
            <end position="1145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00057053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CRL26124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1145" mass="129381" checksum="278057151E894C33" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PIP9</accession>
    <name>A0A0G4PIP9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Beta-ketoacyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S017g000034</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793150">
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        <location>
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        <source>
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        <source>
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        <source>
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    <sequence length="2219" mass="242284" checksum="94A85A7C57280CA9" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJ73</accession>
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        <name evidence="2" type="ORF">PCAMFM013_S017g000221</name>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">FM 013</strain>
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    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1067" mass="116524" checksum="FFB483BDC82233F0" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJP2</accession>
    <name>A0A0G4PJP2_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">catechol O-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S018g000061</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.6" evidence="1"/>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJP2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJP2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006584">
        <property type="term" value="P:catecholamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836:SF8">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G06990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0128">Catecholamine metabolism</keyword>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL26368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="292" mass="32480" checksum="0A48987E7FAA3670" modified="2015-09-16" version="1">MVSGEWYAWSDSDLPTASTRSMSMVNPESDAGKELKLLHYIYEQPNLDDIRGHPQKVIDLIHEFEKQYRFMNVGAEKGKIVTNLIDELKPKTMIELGCYVGYSAILFGDAVRRNGGERYLSLELNPEFAAIANMLVELAGLRDFVRIIVGRSDVSLHKLLTSGEVKKVELLFIDHYKPAYTTDLKLCEHFGAIVPGSVLAADNVLHPGNPPYLEYVRSTVEQKREAAKAGPSQGYNTTGMGERTVQSFVGKDDVPTFQLVGNPNLVYESQLNQPEGLRDAVEVTRCVGVQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJP4</accession>
    <name>A0A0G4PJP4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S018g000079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJP4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJP4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL26386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="120" mass="13432" checksum="5F327A54B7C43C56" modified="2015-09-16" version="1">MIEVQPKVMLVRPTVTFVTIKPKPEVKSTSDTKTKGKAETKAKPKPETKLKPKPDTKGNPEAKIKTETKPKPKPETKNKPEAKTNAKPDTNTKLKPEGKAKLEAKTHKPTQSQYRILRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKJ9</accession>
    <name>A0A0G4PKJ9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde dehydrogenase</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S019g000130</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKJ9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PKJ9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019413">
        <property type="term" value="P:acetate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07091">
        <property type="entry name" value="ALDH_F1-2_Ald2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000001">
        <property type="entry name" value="Mitochondrial aldehyde dehydrogenase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="27"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL26713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="493" mass="53532" checksum="9D4ED43CD3D7B4B0" modified="2015-09-16" version="1">MALSQTVETPVLTYEQPLGLFINNEFVKGVDGKTFETINPHNEKPIVAVHEGTADDVNIAVKAARTALNGEWKQITPSERGRLLTRLADFLERDIDTLAAIEALDNGKGVSMAKGDVTASAGCLRYYGGWADKIYGQTIDTDTNSLTYTRHEPVGVCGQIIPWNFPLLMFAWKIGPALATGNTIVMKTAEQTPLSGLYVAKLIKEAGFPPGVVNVISGFGRTAGAAIASHMDIDKVAFTGSTLVGRQIMKSAADSNLKKVTLELGGKSPNIVLPDANLEEAIEWVNLGIFFNHGQCCCAGSRILVHEAVYEKFLELFKKRAEQNKVGDPFHSETFQGPQVSQIQYDRIMGYIQDGKGAGATVVTGGDRHGSEGYYIQPTIFADVTENMTIVKEEIFGPVCTVQKVQSEEEAIQVANDTNYGLAAAVHTTNINTAIRVSNAVKAGTVWVNNYNTLHYQMPFGGFKESGIGRELGSYALENYTEVKTVRIHLSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKQ3</accession>
    <name>A0A0G4PKQ3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sodium/sulphate symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S020g000083</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793153">
        <property type="protein sequence ID" value="CRL26924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKQ3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PKQ3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006797">
        <property type="term" value="P:polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01115">
        <property type="entry name" value="SLC13_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14478">
        <property type="entry name" value="SPX_PHO87_PHO90_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF92">
        <property type="entry name" value="LOW-AFFINITY PHOSPHATE TRANSPORTER PHO91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="551"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="588"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="641"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="700"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="731"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="770"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="814"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="838"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="866"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="905"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="950"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1000"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="174"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="87"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="291"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="315"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="331"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL26924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1023" mass="113401" checksum="E4155AB14FFFC649" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-11-27" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKX5</accession>
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        <submittedName>
            <fullName evidence="11">Dyp-type peroxidase</fullName>
        </submittedName>
    </protein>
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        <name evidence="11" type="ORF">PCAMFM013_S020g000168</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DyP-type peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793153">
        <property type="protein sequence ID" value="CRL27009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PKX5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049509">
        <property type="entry name" value="DyP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048328">
        <property type="entry name" value="Dyp_perox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006314">
        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01413">
        <property type="entry name" value="Dyp_perox_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30521:SF4">
        <property type="entry name" value="DEFERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30521">
        <property type="entry name" value="DEFERROCHELATASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21105">
        <property type="entry name" value="DyP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20628">
        <property type="entry name" value="Dyp_perox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="DyP dimeric alpha+beta barrel" evidence="10">
        <location>
            <begin position="6"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Dyp-type peroxidase C-terminal" evidence="9">
        <location>
            <begin position="373"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL27009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="553" mass="61553" checksum="4979B6F289FF2811" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PL37</accession>
    <name>A0A0G4PL37_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S020g000025</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="HG793153">
        <property type="protein sequence ID" value="CRL26866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PL37"/>
    <dbReference type="STRING" id="1429867.A0A0G4PL37"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF3">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="87"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="239"/>
            <end position="242"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL26866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="555" mass="59871" checksum="0F7D1B3FA29D775F" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PM38</accession>
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        <submittedName>
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        </submittedName>
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        <name evidence="9" type="ORF">PCAMFM013_S021g000161</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
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    </comment>
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        <property type="protein sequence ID" value="CRL27246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PM38"/>
    <dbReference type="STRING" id="1429867.A0A0G4PM38"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052352">
        <property type="entry name" value="Sugar_Degrad_Dehydratases"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004784">
        <property type="entry name" value="PRK06131.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009560">
        <property type="entry name" value="PRK13017.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43183:SF1">
        <property type="entry name" value="HYPOTHETICAL DIHYDROXY-ACID DEHYDRATASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43183">
        <property type="entry name" value="HYPOTHETICAL DIHYDROXYACID DEHYDRATASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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            <end position="415"/>
        </location>
    </feature>
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            <end position="630"/>
        </location>
    </feature>
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        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL27246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="653" mass="71393" checksum="6C18F373D3F3A9E0" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMC6</accession>
    <name>A0A0G4PMC6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S022g000174</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793155">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PMC6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PMC6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055936">
        <property type="entry name" value="DUF7514"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39611:SF2">
        <property type="entry name" value="HYDROXYPROLINE-RICH GLYCOPROTEIN DZ-HRGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39611">
        <property type="entry name" value="HYDROXYPROLINE-RICH GLYCOPROTEIN DZ-HRGP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24355">
        <property type="entry name" value="DUF7514"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="9"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL27494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="532" mass="60088" checksum="03689151FD78CBE1" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMJ9</accession>
    <name>A0A0G4PMJ9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome biogenesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S023g000130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in ribosomal large subunit assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RRS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793156">
        <property type="protein sequence ID" value="CRL27672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PMJ9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007023">
        <property type="entry name" value="Ribosom_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04939">
        <property type="entry name" value="RRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="175"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL27672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="221" mass="24837" checksum="E7900116C7C13BD0" modified="2015-09-16" version="1">MSDTEMANSAPAAGSKTERLPITVSKPTPYTFDLGHLLVNDPNPLELPADQKLNDSLKATARDGVQVLLNQLLTTCEIKTSVSDGVLLTLPAPNIHLPRHKPLPVPKAPTKWELFARKKGIGKFSQKPGAAGQDKERRKKLTYDEASGEWVPRWGYKGKNKDDENQWLVEVDEKKWKKEAEANAEGGNIRGISRTERKERIKRNERKQRSNEKRSNPARAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNN8</accession>
    <name>A0A0G4PNN8_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquinone biosynthesis O-methyltransferase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinol 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.64</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinone 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Polyprenyldihydroxybenzoate methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.114</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">COQ3</name>
        <name evidence="7" type="ORF">PCAMFM013_S024g000058</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol into ubiquinol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-methionine = a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="2.1.1.114"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="2.1.1.64"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinone + S-adenosyl-L-methionine = a ubiquinone + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:81215"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:19654"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:231825"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.64" evidence="5"/>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EC" id="2.1.1.114" evidence="5"/>
    <dbReference type="EMBL" id="HG793157">
        <property type="protein sequence ID" value="CRL27803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PNN8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PNN8"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061542">
        <property type="term" value="F:3-demethylubiquinol 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120537">
        <property type="term" value="F:3-demethylubiquinone 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00472">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010233">
        <property type="entry name" value="UbiG_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="3 5" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="17"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL27803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="360" mass="38812" checksum="8B3DA66EE226D007" modified="2015-09-16" version="1">MASLRPRTLPLSVRALRSTLRSPRPSPNYLFSAPASTPSTQTHPTRAHSTSSVSADELSHFSGLASSWWDPMGPSRILHLMNPLRHEFIASCLAEGTPSPDPTSTAATLNYLDVGCGGGIFAESLARTIPLDPTSPAPTPTLAASMTAIDPSTDLIQMAREHARMDPTVDTHLRTGRFKYLNTTLEDVLAGNAGAPTPASTQTSNSSSTSTQLTPPQYDIVTLFEVLEHIDPKTSTPLSFLTNCLRALKPGGWLIGSTISRTLPSFILNQVIAEAPWPIGVVPRGTHEWSKFVNPDEVKGWLQEGLMRAADTGVTRGGGAIAEGMRWKCVGAIYIPGIGWKMVPGSEDWGNYFWAVRKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNU5</accession>
    <name>A0A0G4PNU5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Basic-leucine zipper (BZIP) transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S025g000127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793158">
        <property type="protein sequence ID" value="CRL28069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PNU5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PNU5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052635">
        <property type="entry name" value="Sec_Metab_Biosynth_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607:SF3">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607">
        <property type="entry name" value="XANTHOCILLIN BIOSYNTHESIS CLUSTER TRANSCRIPTION FACTOR XANC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL28069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="315" mass="34729" checksum="FF200E6459E2D104" modified="2015-09-16" version="1">MKMEEQSTSPKDEDILSQTQDPLERRRLQNRLSQRNHRRKIRERIAKLQERVIANELRATAALNGWDQAYNPSLFPRSHSSSENELGFTSRDVSPLTPDQCTSFMPSYSPFSQSWPNDFNTFPQHVYPGDVSQFTGASEASPISPITSAPAQPIHSMSPPSSSLNGDTYREMIGTTETLVPDSLSTSAPNQPLYYVATEEALPQIIQVINTMSPQYKVIVLVPPESPASVSMASFPSPSSPYGTSHNGSEQGAPSQQPNPQNMGCQCYPHNVRSGNSAHSTSRPWMGEASYPHVCPLHKTINTGPPRGGFPVRMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNW4</accession>
    <name>A0A0G4PNW4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Flavin-containing monooxygenase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S026g000022</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793159">
        <property type="protein sequence ID" value="CRL28157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PNW4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PNW4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF2">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL28157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="605" mass="68294" checksum="FEC2595BD2A9C8A0" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPQ6</accession>
    <name>A0A0G4PPQ6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Beta-ketoacyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S026g000078</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793159">
        <property type="protein sequence ID" value="CRL28213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4PPQ6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05274">
        <property type="entry name" value="KR_FAS_SDR_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF50">
        <property type="entry name" value="HIGHLY REDUCING POLYKETIDE SYNTHASE SRDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="7"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="12">
        <location>
            <begin position="979"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="2514"/>
            <end position="2592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="454"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="979"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1129"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="462"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="1011"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
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    </evidence>
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</entry>
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            <dbReference type="PubMed" id="24407037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRZ1</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
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                <person name="Debuchy R."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
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        <property type="term" value="C:microtubule"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0003777">
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
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    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
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    <keyword evidence="4 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="15">
        <location>
            <begin position="212"/>
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</entry>
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    <accession>A0A0G4PT79</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
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    <dbReference type="PROSITE" id="PS51371">
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    </dbReference>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
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            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="816"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL29381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="859" mass="95043" checksum="D5649CD5F6988B53" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PTJ5</accession>
    <name>A0A0G4PTJ5_PENC3</name>
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        <submittedName>
            <fullName evidence="8">Flavin-containing monooxygenase-like</fullName>
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        <name evidence="8" type="ORF">PCAMFM013_S036g000035</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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            <dbReference type="ChEBI" id="CHEBI:57692"/>
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    </comment>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL29451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="485" mass="54734" checksum="4AA8087F894DD783" modified="2015-09-16" version="1">MAITNHIRRVAVIGAGPSGLAAVKYLLAEKIFDQIEVFEQRSSVGGVWNYTPSSSKKGISTAVPQLTPHEPVEKPVWVDSAEGREATFVSPLYDRLETNIPKELMRYSDQAFPLESQLFPKHRTVRQYLEDYAEDVKGLIQFETQVLEVKLEDETLSTWSLTTKNLPTGIDTTHTYDAVVVASGHFTVPYIPDISGIQAWDASYPGVISHSKFYNSPEPFEGKKVVVVGNSASGLDIGGQINEVSQGKLLLSQLSESYLAAPPNGDKIICPEIVEFLPSTTHDRGIKFADGRIEEHVDAIVFCTGYFYSYPFLSSLNPPAVTHGWRTMNVYQQLFYIDHPTLVFPVLSQRVIPFPMAENHAAVFSRVWSARLTLPPKDEMKAWEASEIEAKGDGKEFHLLPFPKDADYLNFLYDWAEKAEARPGLSNNGQGKLGTWWGERERWMRSNFPDIRRAFIQRGDERGEIKNLAELGFDFEEWKRQQVDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUC1</accession>
    <name>A0A0G4PUC1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome oxidase assembly</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S039g000078</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2</text>
            <dbReference type="Rhea" id="RHEA:63388"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:61715"/>
            <dbReference type="EC" id="1.17.99.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:63389"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793172">
        <property type="protein sequence ID" value="CRL29769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PUC1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PUC1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120547">
        <property type="term" value="F:heme A synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01665">
        <property type="entry name" value="HemeA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023754">
        <property type="entry name" value="HemeA_Synthase_type2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL29769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="496" mass="54598" checksum="112F8C2144BB4684" modified="2015-09-16" version="1">MASLGSSLSLWRGVAPRLAKDFFTSQCLPSQGYAAKSIRQFGALQFRQPTKIQSNLLNNKKFFSSSLNRSNAAPAVAEAVEGGSAKAKSSFPKVSDKAVAYWLLGSAASVFGIVVFGGLTRLTESGLSITEWRPVTGSLPPMNAEHWEDEFSKYRASPEFQLLNPNMTLSEFKSIYYMEWIHRLWGRFVGISFVLPAVYFVARKKVSTPMAWRLFGIAGIIGFQGFLGWWMVKSGLKDDLFAPGSHPRVSQYRLTAHLGAAFVCYVAMLWNGLAILRSNRLMADPVAGINQLNALRDPKLAFFRRSVAGIALLVFTTVISGGLVAGLDAGLIYNEFPWMGKGLAPPKEELFDARYSRHEDRSDLWWRNMLENPSLVQLDHRALAVTTFTVICGLMAYTRGSPTMKRFLPAPARKGVHGVFAFACCQVGLGITTLLYLVPTPLASAHQAGSLFLLTWVMILGSRVWHPSRTAKLLQMAAKARSQQLSSTAASAVKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUV6</accession>
    <name>A0A0G4PUV6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S048g000017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793181">
        <property type="protein sequence ID" value="CRL30305.1"/>
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</entry>
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    <accession>A0A0G4PVH1</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            </authorList>
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        </source>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF43">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PWL1</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="HG793227">
        <property type="protein sequence ID" value="CRL31253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4PYH2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018371">
        <property type="entry name" value="Chitin-binding_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029476">
        <property type="entry name" value="DNase_NucA_NucB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053214">
        <property type="entry name" value="LysM12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700:SF2">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700">
        <property type="entry name" value="V CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14040">
        <property type="entry name" value="DNase_NucA_NucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00026">
        <property type="entry name" value="CHIT_BIND_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="4 11" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195833" description="chitinase" evidence="14">
        <location>
            <begin position="19"/>
            <end position="1865"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="15">
        <location>
            <begin position="59"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="16">
        <location>
            <begin position="117"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="801"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1406"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1630"/>
            <end position="1678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="804"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1447"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="95"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CRL31253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1865" mass="207971" checksum="3959AAE08ACD755D" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PYQ0</accession>
    <name>A0A0G4PYQ0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S3Jg000080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793312">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PYQ0"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL31469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="296" mass="33100" checksum="B260A4370D51EB22" modified="2015-09-16" version="1">MLARGMLPQEGRCLPQLYTMDTLDYRNLRNCAIGVIIGTLGFSYFVIYLLMFLIFHFPSSQQSIPYALTVMAFGGGSAIWYLCVIFQNCFSAFQKEKMRKEQDSVWFGGLFLVWTAALPTIAFLFPAQPLLQLGCASAFTMIAVGSLSDGYLKDMDMGAFSARLSLQFASVVLLALVPSIHALAEPLHAPSPLATAFGRLVLLNLCGYALYALRPLEKIGMVQFWQPSLHGMYLILTYSLVEYSKAVGLQRLGRMKRHVMLSIVRFIPGLLSSWESLRVFFRGTRRNVADLKSPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PYR3</accession>
    <name>A0A0G4PYR3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S4Jg000053</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793313">
        <property type="protein sequence ID" value="CRL31531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PYR3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PYR3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF82">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="6"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL31531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="673" mass="75076" checksum="379B855470473563" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PYX4</accession>
    <name>A0A0G4PYX4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE affecting a late Golgi compartment protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S145g000002</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793275">
        <property type="protein sequence ID" value="CRL31370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PYX4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PYX4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21444">
        <property type="entry name" value="SNARE_NTD_Tlg1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15851">
        <property type="entry name" value="SNARE_Syntaxin6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.90:FF:000012">
        <property type="entry name" value="SNARE domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000006">
        <property type="entry name" value="Syntaxin 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015260">
        <property type="entry name" value="Syntaxin-6/10/61_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048036">
        <property type="entry name" value="Tlg1p-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09177">
        <property type="entry name" value="STX6_10_61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="150"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="40"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL31370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="255" mass="29058" checksum="6C4975D4AF97F61C" modified="2015-09-16" version="1">MEHADPFLQVQADVVSTLQTSRPLFSSYLRIRSLAKSPNNPELKQARSELEATLTELTADLNDLVESVRAIEQDPYRYGLELEEVQRRRKLVDDVGDEVEKMHQELQQAVSNSAVDTLPNPTEFDAALEEEERGRGGDDYYASMEQQRQSELMHEQDEQLDGVFRTVGNLRQQADDMGRELEDQAVMIDEVDTLADRVGGKLANGMSRIKHIVRKNEGKSASFSFCLFTLSMLDLYWDGWCGMVWESQVQTNFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NSR0</accession>
    <name>A0A0G4NSR0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Berberine/berberine-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S001g000068</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NSR0"/>
    <dbReference type="STRING" id="1429867.A0A0G4NSR0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF9">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005194862" evidence="6">
        <location>
            <begin position="31"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="71"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL17108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="503" mass="53864" checksum="1C5EE8DDDC7C4EBB" modified="2015-09-16" version="1">MYRLKLEVITAVAAWAFSAASLTFPSGIEGGLCPRGDADLEALGKKLSSTAKVYSPGSTGFTDVTTRWSALAEPKVNIVVVPGNENDVVETVKFANKKDLPFLTYNGVHGALISLGKMDHGVGISLSQLSSVKIAQDGKTATMGGGTMSKVVTDSLWAAGKQTVTGTCECVSLLGPALGGGHGWLQGHHGLVSDQFVSMNVVLADGTLKTIDESSDLWWAMKGAGHNFGIVTSLTSKIYDIQHRDWAIETISFSGDKVEAVYEAANEYLLKNGTQPADLINWSYWMNNPDVDATNPVIVFYIIQEGVTAVDSIYTKPFHDLGPLSAVPQAGTYKDLAAWTGIALDSPPCQNAGYANPRFPIYLQSYDIAAQKKAWDIYAPAISGSSAYNNSILMFEGYSFGGVHAIPSSSSSFAFRSENLLAAPLINYPPGDATVAAGAVDLGNKLRNILFEASGFEDIRAYVNYAYGDETTKQLYGDSEQRLVALKKKYDPTGKFSFYAPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NSR8</accession>
    <name>A0A0G4NSR8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S001g000037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="CRL17077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="460" mass="52118" checksum="AF9BCFA99751D515" modified="2015-09-16" version="1">MSRSWKQVRAYADHLGHPVVLEQYVNPEYEPEPSELVAFQVYSLAPLDDDHDKLRDYLMQMFWNNEVKPLFEIYSYRPPDGFACIEHNRIEIARRKQQHQLGVKNPLPLIPRFNRPYSSSNVGFCVLIRSHSYRVGNMQDSEEAEEIGEGPDLLYFNRTFSSTCTEVDVAQHLREGQEELPSEAFEFVIERLIDQIYIGQLMILDIFNNVPRYPERDALGIDEGEPPSQDMPTKEQIRDQLDQETSGSGFFSLDPAFHISQEANIVTVTNTPKGETPDIQYIIHTAFLSHIRDAEGSSILESTALLFTASMVSNLPANKTLTLKFFIPKSNSWSAIRPAQNEVLKILSQRNEENRENPFSIGALHNITTGSQPLAAKRFTPQGPDQYIKSSQGACDDSGFRTFTVVLDRAKFVSEAGVYFYMTDSDESEDPDTSADDTIVSRVVDMNTAARRLGVVVLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NTJ8</accession>
    <name>A0A0G4NTJ8_PENC3</name>
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        <submittedName>
            <fullName evidence="4">Alkaline-phosphatase-like, core domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S001g000333</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NTJ8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052701">
        <property type="entry name" value="GAG_Ulvan_Degrading_Sulfatases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43751">
        <property type="entry name" value="SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43751:SF3">
        <property type="entry name" value="SULFATASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="3">
        <location>
            <begin position="529"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="744"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="759"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL17373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="884" mass="98553" checksum="8CEFC6FC8F2517E3" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NTP3</accession>
    <name>A0A0G4NTP3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitrilotriacetate monooxygenase component A/pristinamycin IIA synthase subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S001g000411</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4NTP3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF41">
        <property type="entry name" value="XENOBIOTIC COMPOUND MONOOXYGENASE, DSZA FAMILY (AFU_ORTHOLOGUE AFUA_3G15040)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="3">
        <location>
            <begin position="38"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="453"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL17451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="481" mass="53394" checksum="7358CA849EDF1C57" modified="2015-09-16" version="1">MSEDTPTSSKKQIILNAFVMNTPGHLAPGLWKHPRNKTDQYKSLSFWTELAQLLDKAGFHAMFIADTLGAYDVYKGPGNVVPALASGAQFPVNDPLYLVPAMSAVTKNLIFGVTASVTYEKPYALARRLSTVDHLSEGRVAWNIVTSYLDSAARNHGLDEQIPHDERYARADEYLEVLYKLWEGSFRDDAVLADRQLGTYIASDAVREINHKGKYFSVPGPHFCEPSPQRTPFLFQAGVSEAGGQFGGKHGEAIFIGGQTPEGTRLTVDNVRNVAKEQGRDPNHIKVIVGINVIVAATDEEAKAKREEYLQYADDEGALALFGGWTGIDLSGYADDEDFRFSDSPRVQSIVRRWSATVPGTDSLPWTKRRIVEYISVGGLQAKIVGSPTTVADELEKWVEISDVDGFNLAHIVNPGTFEDIIEFLLPELRQRGLFREEIEKEGATAREVFIGSQRLPEDHPGSKYKWRAGETIPQYQTTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NTT6</accession>
    <name>A0A0G4NTT6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S001g000450</name>
    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL17490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="78" mass="8669" checksum="9533831331E99A6F" modified="2015-09-16" version="1">MLRFTLIEPKAASPRQELMIGCSSQPWKSDPHIIRLTSPPLAGPIERRTARPRGIGWTEVEEIIGILDDAHCAIEASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NU54</accession>
    <name>A0A0G4NU54_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S001g000454</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NU54"/>
    <dbReference type="STRING" id="1429867.A0A0G4NU54"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
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    </dbReference>
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        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL17494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="295" mass="32282" checksum="85CF5F2BEA14D780" modified="2015-09-16" version="1">MSSIAKTVIATGTSSGLGFEAIKQLLQQTQPYSFILGVRDTETTRVAYDDLKFDTSKHSVSVLPLDLLNLKSVQSFAKQALSELGQRPLDYLFLIAGLVASADGPGPHGSQWCESYVVNHLAQHYLTHHFAETLSASQSRVVIVSSGAIRNVRGGDPRTLDVDLKANSGANARVVYSASKFTQLLGAHYWRRSLPNCKVVAVSPGLIPNTKLARHSSLGLTMDMPDAKTVPEGAQNILRAVTADNLPADPEQIFLTSWGEWWPKDVYASSLDRALQDKWCLSKEDIEKSEPVFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NUH1</accession>
    <name>A0A0G4NUH1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AMP-dependent synthetase/ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S001g000683</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRP synthetase family.</text>
    </comment>
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        <property type="protein sequence ID" value="CRL17723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4NUH1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000047">
        <property type="entry name" value="NADP-dependent L-serine/L-allo-threonine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
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        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF6">
        <property type="entry name" value="BETA-ALANINE-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="528"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="504"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="514"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL17723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1275" mass="137155" checksum="1B97EA323094A964" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NUS9</accession>
    <name>A0A0G4NUS9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S001g000734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NUS9"/>
    <dbReference type="STRING" id="1429867.A0A0G4NUS9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL17774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="276" mass="30773" checksum="25809832FBEB0666" modified="2015-09-16" version="1">MFATQSPQTPFRKTHYSPTRPSPLSKHTTTPPLWNMSPTRSIQSASQSTAPNPFSNPPPIFNIQTEPIARHTQNHHSPIPMQFNASASASTTPTSSSNPFFIQPQTPASPSSPTRQKPKYEARYASTIANPLQGATGLARSKTRKMFLNRVRHERDDGRFEARGEQMMRMEHLADRRRWEESMARDGEGVVGGFEGDEDDMLPDDADLLDEFISQEEAMEMALMETHSGVPARVGDLRSNGPGVLFSDDEYDDIFMGLPEPLGNQCESQSQDMDMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NVD1</accession>
    <name>A0A0G4NVD1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S001g001003</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL18043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NVD1"/>
    <dbReference type="STRING" id="1429867.A0A0G4NVD1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063:SF60">
        <property type="entry name" value="LYSOPHOSPHATIDIC ACID:OLEOYL-COA ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063">
        <property type="entry name" value="PHOSPHOLIPID ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL18043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="328" mass="36666" checksum="0E7C59FEEE412B0F" modified="2015-09-16" version="1">MERYSQFRDRGSGIAPFLPIPVERLGLQAPLRIFLFCFRLPLFIFVTLSYFLILQWLPIGSLGKKAALWCILGVPSIWWIDLQVDGVRKGSLKQQQARLPQPGSVIASSFTSPIDAVYLAAIFDPIFTASYPNTRQVERISLLQAILRAFASPATQPAPGTQMVDVSTLVEQYPSRPIVLFPECTTTNGRGILTLSNSLLSVPPKTKIFPVSLRYTPMDIVTPLPGSYMSLLWTLLSKPTHCIRVRIAECITNSQNATDSTRKSTYNTNYLDTLDQSGQEEQISPSEKALLDNVGESLARLGRVKRVGLGVKEKQEFSRAWSQSRRTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NVI5</accession>
    <name>A0A0G4NVI5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase A2A, retrovirus, catalytic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S001g001053</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL18093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NVI5"/>
    <dbReference type="STRING" id="1429867.A0A0G4NVI5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="87"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A2" evidence="5">
        <location>
            <begin position="104"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="271"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="569"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="888"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="924"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="638"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL18093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1250" mass="137346" checksum="09EA94A3F13275FD" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NVI8</accession>
    <name>A0A0G4NVI8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aspartate/other aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S001g001058</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL18098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NVI8"/>
    <dbReference type="STRING" id="1429867.A0A0G4NVI8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF55">
        <property type="entry name" value="GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="29"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL18098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="406" mass="45082" checksum="8F1447B5D7C96C88" modified="2015-09-16" version="1">MGMFENVLPGPIDPMFDLKKQADNDKSSRKVDLGVGIYRNEEGNYHEINAVHEAKRILFEKNPGHDYESTTGNPEFLKSAAAIMFGDTCEALTSGRIASVQTISGTGANHLAAVFLARCETSSSPKVYIGTPTWGNYEPLCTLAGLDVVKFPYYDPKSATVNFPTLLEQVLQALPGSIFILQPCCHNPVGMDLSQSQWNRLADAMKEAHIFPWFDIAYQGLGDSLIEDAYAVRHFVEMGFEMAVCQSFSKNFGLYGERCGTLHVVCKSDTTAANVYDQLRCLIRWEISSSPLYGSRIVTSITGDIHLKKNWSDELSIMRDRLRSNRLELHEALKGNPGSWDVIIKTKGLFCCLPLAPWQCQQLRNEHHIYLPDNGRINISGLNSSNIGRVASAIVAVMQDSNQAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-11-27" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWB3</accession>
    <name>A0A0G4NWB3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent phosphohydrolase, HD domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S002g000159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWB3"/>
    <dbReference type="STRING" id="1429867.A0A0G4NWB3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008832">
        <property type="term" value="F:dGTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3210.10:FF:000026">
        <property type="entry name" value="Metal-dependent phosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050135">
        <property type="entry name" value="dGTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373:SF4">
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    <sequence length="339" mass="37437" checksum="6E6051882FB82FBD" modified="2015-09-16" version="1">MATVNLLEYLRSRTQVDIDTYDAEASKEIGPFQDATGNQFEIQAEIVKPNRSAVLKRSLDLATTIHSQFATITLEELAVEVVGIELALEVIQTIHGNVHVMVNPSYSYNTEAIVANAQRLHHICQIVDPDFDTSRLVTKVPTTWEGMQASRQLKRSGIKTLATTLFSMEQAILAGEAGCISISPFVHELKTETYKGYKDTNPILGVCVQAQRFYHQNSLPTRVKACVTLNLDELIMLAGIDALTIAPKVLKVLAATERPQDEVESMSLFAKTAKATEIVKYPSYIDSESQYRVHFAASEGGKAQFKTAQAISLFCDAQTAVELYISSQLEDSSYIPINL</sequence>
</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="entry name" value="Znf_RING_CS"/>
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        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR OF YEAST FORM ADHERENCE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="91"/>
        </location>
    </feature>
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        <location>
            <begin position="118"/>
            <end position="156"/>
        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        </location>
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        </location>
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        </source>
    </evidence>
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        </source>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="532" mass="58754" checksum="75F80C5ADBD9D872" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXP5</accession>
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        <submittedName>
            <fullName evidence="3">Glycoside hydrolase, chitinase active site</fullName>
        </submittedName>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Putative G-patch DNA repair protein (Drt111)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040052">
        <property type="entry name" value="RBM17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288:SF8">
        <property type="entry name" value="SPLICING FACTOR 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288">
        <property type="entry name" value="SPLICING FACTOR 45 SPF45"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="418"/>
        </location>
    </feature>
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        <location>
            <begin position="49"/>
            <end position="108"/>
        </location>
    </feature>
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        <location>
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        </location>
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        <location>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="139"/>
        </location>
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        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL18826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="542" mass="59426" checksum="3FE8ACB21C55B379" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYU5</accession>
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        <recommendedName>
            <fullName evidence="3">DNA polymerase lambda</fullName>
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        </recommendedName>
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        <name evidence="16" type="ORF">PCAMFM013_S003g000012</name>
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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        </lineage>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM 013</strain>
        </source>
    </reference>
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        <reaction evidence="12 18">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
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            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA polymerase POL4"/>
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    </dbReference>
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        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
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    </dbReference>
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        <property type="entry name" value="DNA polymerase, thumb domain"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DNA POLYMERASE LAMBDA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14792">
        <property type="entry name" value="DNA_pol_B_palm"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
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    <keyword evidence="5" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="484"/>
            <end position="580"/>
        </location>
    </feature>
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        <location>
            <begin position="432"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="585"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="700"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="454"/>
            <end position="466"/>
        </location>
    </feature>
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        <location>
            <begin position="724"/>
            <end position="736"/>
        </location>
    </feature>
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        <location>
            <position position="817"/>
        </location>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022932"/>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL19221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1082" mass="120307" checksum="A48803179DBAEFE2" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYZ0</accession>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
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    <keyword evidence="3" id="KW-0862">Zinc</keyword>
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            <end position="41"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL19292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="567" mass="61074" checksum="E838202CB5DDF3F8" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZK5</accession>
    <name>A0A0G4NZK5_PENC3</name>
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        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S003g000279</name>
    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
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            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL19488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="178" mass="20586" checksum="966D28F402501DD3" modified="2015-09-16" version="1">MVRKVPIPTLTVEQLELLDQLRERADDREHAYAIIIQEVQNIMRMVGRVSSLQLGDIPHSSPLIPAVMRALETQMIRLLEVVAELSVEAQMDEWTRRWIFDTIVELDGSPERVAQFSHSKHKSVDTEDRVHHWYGAVQNFRRSVSRLAEEGSLDSNVVQQECARLIERFPREILPATH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0N8</accession>
    <name>A0A0G4P0N8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S003g000677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Debuchy R."/>
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            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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    </evidence>
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    </evidence>
    <sequence length="424" mass="48054" checksum="E80733492600BCC9" modified="2015-09-16" version="1">MAHIHPLKWKKPSTSTNSDSSKDSDSAQAEVSFPSSSNQMRHPWGVFDYHMYLSHIESKRDELRRKKECHLLGATGFRQVTLHDEPELDDIRANTNPKVVFVSLPVPDMQDEFSNARLVLGFDLKSDRLQGYFFESEVPIENYEDLWQVWNQGGGELVIDVPVQRFLSVIRHTMQEQIEILEIGVLHHYGLTTRVFQAGLDMVIAVQFLQFVDDFAELLTEETYELRGLYLPFQDELRNLLEGGSRDAWFAVRDGLDIQQYRQKQLKKVVASGLFHGQNAVVLREGPEKTPQKEKTSRPVKIMPCHSSPWSWSKLQMQVLAEVERGYKEESDKPTLIEAKSAPPPSLAQSGIARNNLCGATWLDGIVAAIIFSPIGQVITGKSWQRQSCSFESCNLLYCQGSGPKGTDPQLLISLRFLFTLSAL</sequence>
</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Dupont J."/>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        </source>
    </evidence>
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        <source>
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    <sequence length="83" mass="9151" checksum="7B2FCF0DB74F1960" modified="2015-09-16" version="1">MSSSLILLQTPSLRSNPPVALTFFSTSTYLITGELGFLGLSTGSHKPETESMIQSILFLERLGATIHFLAIYISYLSAIWNVR</sequence>
</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Dupont J."/>
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            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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    </dbReference>
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    </dbReference>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL20289.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="550" mass="62596" checksum="B3E59205EEAD86D0" modified="2015-09-16" version="1"> </sequence>
</entry>
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    <accession>A0A0G4P2H7</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            </authorList>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
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        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="2"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
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            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="89"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="118"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="147"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL20453.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="334" mass="37934" checksum="11DCF184D685490E" modified="2015-09-16" version="1">MERCDLCDRFFDDRQALQQHIRDAPAHTLIFPCEPCNRTFVSQSALEQHTRDSPVHTITHECEPCNRSFGSQSALDQHIQYSPAHAVSFSCELCDRSFGSQIALDDHVKDSPAHTITHECEPCNRSFGSQSALDQHVQYSPAHAASFHCDLCNRTFGSKEALDQHIQYSKAHITPPSTPLDEFFQSFAGFSYNPKLPPSESYAQLKRFCGWAQYDPEDKEAWEQYQSALEAEVKMWFGAEDDLGAWHSLCRAIGIEPLPATCKQAVKVIRGVFVNIVDLIAWARSGRINNQVQRFSSLEKLRKYTKQTNKFFHNQLDGGDGGNIVLRHLLRFIL</sequence>
</entry>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
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                <person name="Abraham A.L."/>
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                <person name="Debuchy R."/>
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            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
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    </dbReference>
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    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
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    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195118" evidence="5">
        <location>
            <begin position="18"/>
            <end position="1140"/>
        </location>
    </feature>
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        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
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        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1016"/>
            <end position="1048"/>
        </location>
    </feature>
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            <end position="1081"/>
        </location>
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        <location>
            <begin position="1082"/>
            <end position="1115"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL20556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1140" mass="127281" checksum="B244A8A1700D9456" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2R9</accession>
    <name>A0A0G4P2R9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA-dependent RNA polymerase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S004g000562</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
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        </lineage>
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    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
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        <reaction evidence="7 8">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the RdRP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="8"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
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        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058752">
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF55">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26253">
        <property type="entry name" value="RdRP_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 8 13" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="53"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="RDRP core" evidence="11">
        <location>
            <begin position="467"/>
            <end position="1047"/>
        </location>
    </feature>
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        <location>
            <begin position="1071"/>
            <end position="1213"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
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        <location>
            <begin position="1251"/>
            <end position="1308"/>
        </location>
    </feature>
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        <location>
            <begin position="1255"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1298"/>
            <end position="1308"/>
        </location>
    </feature>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF26253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL20621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1356" mass="153333" checksum="FA903B69F1F767DD" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2V3</accession>
    <name>A0A0G4P2V3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ribosomal protein S4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S004g000580</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P2V3"/>
    <dbReference type="STRING" id="1429867.A0A0G4P2V3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="InterPro"/>
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        <location>
            <begin position="4"/>
            <end position="104"/>
        </location>
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        <location>
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            <end position="178"/>
        </location>
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        <location>
            <begin position="159"/>
            <end position="190"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL20639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="190" mass="21769" checksum="FD43E7EEAE5BE8DB" modified="2015-09-16" version="1">MAPRVSSKTYKVPRRPFESARLDAELKTVGEFGLRNKREVWRVQLTLSKIRRAARELLTLDEKDPKRLFEGNALIRRLVRIGVLDEARMKLDYVLALKADDFLERRLQTCVYKLGLAKSIHHARVLIKQRHIRVGKQIVNVPSFMVRLDSQKHIDFSLTSPFGGGRPGRVRRKKAAAAAGGEDAEEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2V9</accession>
    <name>A0A0G4P2V9_PENC3</name>
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        <submittedName>
            <fullName evidence="10">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
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    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S004g000524</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF3">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
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        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL20583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="474" mass="53413" checksum="CD9371236D61A034" modified="2015-09-16" version="1">MSEKITQSVLRCTECNKPFDKESTLKRHGYYCRSRAIGHTPRPRSCHLCAKTKTRCDKKWPKCSRCIAKGIECQYGSKSPKSQKLAIQDSNSSLDLSNYQADLNRDTIRHDELVVVDQEITELEHEYLNWDVPDYNFAEFSNVHTSQTNLYPWTGGFPVSPVTPPIDQEFQINIPIAANWSMPASPTPKPHSLIKRPKSNVGIERTAKLLLHTLKSYVFTMLRHNSLPPFIHPSLVHSEFSMEPLINCINLVHMISGDMKGNRKLFWRNVRMECERLCDEGPTLSKWELLAAMQALAIYIIIRLDDGETEYNGFDSLLIAAVTVVAQKLTESDIAGNFSLDGSWEDWLFEESRRRLSVVYKVFNMLFYFEPAAMCNLPTDLVLAPLPAKKQLWEAGSEAVWKSESQREGEVQTEFGLTGSGDLVKLGENHGGTALVHTSITASNPARSTASWEEWCEGMDGFGGLVMLAASMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2W4</accession>
    <name>A0A0G4P2W4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S004g000529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4P2W4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL20588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="177" mass="19569" checksum="B1A454AB8DC74849" modified="2015-09-16" version="1">MESVTASQLQSFNALQRPEKDASGKRNHYHFAVKALPGVPGEAVFFANPYNNHHECEGRSRISPLSPDEQAKIIVPLLLEAFVNRFDEPGPIPQMGSNMEPFAPFTWSTTDESLAQAVSHRCQAIGMRRELCDVAVTTAEELRSAEACWTKWSKGLVEAMAMAHEAHNPTRPDPLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2Z2</accession>
    <name>A0A0G4P2Z2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S004g000633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P2Z2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL20692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="66" mass="7274" checksum="8F8CB6329D62FD29" modified="2015-09-16" version="1">MTQTLANTGPDPVTQMQICVYGGGSDTAPSSVMFRRSIRCTKRSGSWTRHGRIPHQYVYSVNVGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P388</accession>
    <name>A0A0G4P388_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S004g000659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P388"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL20718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="82" mass="9347" checksum="7927F333B2BAFCC2" modified="2015-09-16" version="1">MAPRSPMITQWTPLWTSRRAYQVPILATKRQCHAPDRPRQQQEDQTRCRTLLLAIRSRVWSIKTSASEPFVPSQSAAIGQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3A7</accession>
    <name>A0A0G4P3A7_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">xyloglucan-specific endo-beta-1,4-glucanase</fullName>
            <ecNumber evidence="4">3.2.1.151</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Xyloglucanase A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Xyloglucanendohydrolase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S004g000725</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>xyloglucan + H2O = xyloglucan oligosaccharides.</text>
            <dbReference type="EC" id="3.2.1.151"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glycosyl hydrolase 12 (cellulase H) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.151" evidence="4"/>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P3A7"/>
    <dbReference type="STRING" id="1429867.A0A0G4P3A7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033946">
        <property type="term" value="F:xyloglucan-specific endo-beta-1,4-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002594">
        <property type="entry name" value="GH12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002">
        <property type="entry name" value="BLR1656 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002:SF9">
        <property type="entry name" value="XYLOGLUCAN-SPECIFIC ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01670">
        <property type="entry name" value="Glyco_hydro_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195128" description="xyloglucan-specific endo-beta-1,4-glucanase" evidence="8">
        <location>
            <begin position="21"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL20784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="250" mass="26904" checksum="1857A0B16BBC14F1" modified="2015-09-16" version="1">MKSFAPITILSLALAAVSNATVVSPHGALSKRADFCDQYGTVEKGSYKVYNNAWGQQYDQAGKQCTGVDSLNGNTISWHTSWSWGGSKTQVKSYPSVGLNFTAKQLSAVRSIKSNWKWSYSNTDVVADVAYDMFLSSTADGSEEYEIMVWLAALGNAGPISTTGSPIGSVTIGGIPFKVWKGPNGQMTVYSFVAESTVNSFSGDMLEYFTYLIKDQGLSSSLYLIDVQAGTEPFTGKADMKTSAFSIEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3B1</accession>
    <name>A0A0G4P3B1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S004g000684</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P3B1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL20743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="73" mass="7994" checksum="0AFB4CD9D0FAE89E" modified="2015-09-16" version="1">MIARLPKSFLDYGVYALPHTVYNSTPSSAYLVRSELGQVSEDFLPISDRGPSLTTLLQSAVRQAIPAFGLPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P4Z5</accession>
    <name>A0A0G4P4Z5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S005g000537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P4Z5"/>
    <dbReference type="STRING" id="1429867.A0A0G4P4Z5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="3"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL21373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="500" mass="57892" checksum="029043768FEC61DB" modified="2015-09-16" version="1">MTATLPLELLFQIATLLQNDGNSLVPCTCVCRSWQPAFEPLLYSNLAVYSDDKHKEEGQRGISLQNFQKLISGDHAIRKTYIRKLEYNILVPYEVLDWIARKHRESPENYSADNPIRKDNDLAFQTAMVSLFQELQSWDQSSRLRLNLAIRGRRQGLALEPHTQHSEIAADYRWDYRDGRILSIPPYRARFLEDMPDLPSLPCIEKLSFPNRNQIWTGAMRTIIQRCTQIVELEIDLEEFVRPDHLEYIQARREALSSLLGSIPKSLRVLLYQGHDDAPWKPAMSPLNVIPSGVDGASSNLRDLSIHLQQLKLVNTSIAYDFLCPLDEKGRPEPGSLQLNWPYLEVLELEGIPPWLPSGEPTYHNTPEDQSEIDEIENWEDVICDVEAGWGWPELPTEEHFHRLLISLGYAAQRMPRLKKVKIEVESHRQFTFCLQKKANQTILEWECFYPYRPDSRMAKAWDFDLDDVKSHLQYEDKSSVILRTWPPNTPFLASAFVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P508</accession>
    <name>A0A0G4P508_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S005g000546</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21382.1"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0813">Transport</keyword>
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        <location>
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            <end position="103"/>
        </location>
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        <location>
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            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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        </location>
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            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
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    <sequence length="605" mass="67414" checksum="7B268F411160B703" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5F4</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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                <person name="Dupont J."/>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="417" mass="46226" checksum="17F1024DFADD4BDA" modified="2015-09-16" version="1">MHPTQTTGGPNLNISIAAPPLWTYAAGDTIIGSVNRHSHIVAPDAKISLTLIGRTRARLITEGYPSKISSYGNWRFFELPSQTLLRGPIHIPSPSTPTDWINIPFSINIPEAASLSAARNRTQSESFIPLEADCITQHPLPGTFSTKWTGAKVYIEYYIQAQLRYIRNGLWYAQRATAPIMLGYPTVDAGGIRFALQRCSIVSRVRSQRLLPSMRDVDLSLMQKTRKILGLSSVPGFSFEVVMSVPVAIQLDDSSPIPLVMRVIPRRDGSSSDIWDVVQRVDVIAVKMSILSKVEILLKPSEESFYKIPNDEHVFVQDLGLEKAFEQRKDPIVTFAGPSDAPVDIGRVLRLALRHDGLMSDEKRLSVLASNIQPSFVTFNTRLSHSILWQTSLSIAGETRTVSMTTVVTVYNSASRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5S7</accession>
    <name>A0A0G4P5S7_PENC3</name>
    <protein>
        <submittedName>
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        </submittedName>
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        </lineage>
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    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="LPMO_auxiliary-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BIM1-like"/>
    </dbReference>
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        <property type="entry name" value="BIM1-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992:SF5">
        <property type="entry name" value="ANCHORED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G02800)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20238">
        <property type="entry name" value="BIM1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
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        <location>
            <begin position="19"/>
            <end position="279"/>
        </location>
    </feature>
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        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Copper acquisition factor BIM1-like" evidence="11">
        <location>
            <begin position="27"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL21629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="279" mass="30021" checksum="716B02F1B05C8EE4" modified="2015-09-16" version="1">MRNYIALIALSAVGGLCAHGDEASTEMGPAAFLWPPDRLWGAAYDNNAPCGSSTGAVNRTNFPLINGKLALVLQDESWNVQVAISHKSNPTTNDDFEPFINGSTLSDIEPGHECYSVPNPSIDIEEGMNATFQIKYTSDFDTDKNETYYACADVTYIAASKFTYQVPCFNVTSDEFTDATTTTTATTGATATAASGSTKNADTTSEKSSGLSGGAIAGIVVGSVAGLAIGIALLFFYRRLLQKYRFLRQKASTRNVDWNEEAPQHKVDDEVPIGLRKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P607</accession>
    <name>A0A0G4P607_PENC3</name>
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        <submittedName>
            <fullName evidence="8">Ribosomal protein L14</fullName>
        </submittedName>
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        <name evidence="8" type="ORF">PCAMFM013_S006g000259</name>
    </gene>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
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    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL14 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CRL21719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="term" value="C:cytosolic large ribosomal subunit"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="60S RIBOSOMAL PROTEIN L14"/>
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    </dbReference>
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        <location>
            <begin position="62"/>
            <end position="89"/>
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    </feature>
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        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL21719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="197" mass="22261" checksum="5931508E65135B74" modified="2015-09-16" version="1">MLHSPRPASGRLSENVASVGTSEFRDNSWTIELFRQPLLDSYPLSTNFAMADIDVKVASWKLVEVGRLVLIRSGPFEGKLAAIVEIVDHRRVLVDGPSTEEQKIVPRHVLPLAHATLTHFTIPQLPRAAGTGPVKKLWAKNEIDGKWAKSSFSQRTDRSERRKNLSDFERFKVLRLRKQARYEVQKSHAKARAANKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P667</accession>
    <name>A0A0G4P667_PENC3</name>
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        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <lineage>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793139">
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    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4P667"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL21754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="765" mass="88660" checksum="1FF835DA4181887A" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6Q5</accession>
    <name>A0A0G4P6Q5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S006g000434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:iron ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL21894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="121" mass="13519" checksum="2919AB9D15CCDC16" modified="2015-09-16" version="1">MNKTSVMAMISDLMAFSAQYIFIVVPLLIIIHLTRNYFTPGVCVVPGPFLAKISNLWRFFDVANGSAETTLYNLHRRHGDYVRLGPNVVSVWNLDALKIIYGINKGYKKVSVVVGALQCGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P720</accession>
    <name>A0A0G4P720_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aromatic-ring hydroxylase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S007g000114</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P720"/>
    <dbReference type="STRING" id="1429867.A0A0G4P720"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="13"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL22133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="440" mass="48378" checksum="1F0AD313056B2950" modified="2015-09-16" version="1">MTDQHTSTQGEFRIAIAGAGIGGLTVAIALARLLPSNVSVTIFEQATELKAVGASIGIGPNGLRSLYKLGVDPALIEEFAFRQPRGRPFVYLHWLTGEVLKETAHHTVKDPRDAMARFHRADLQKLLLESLPAKVTLKLGKRVKSVDIQSPQEGGGVLLAFEDETTFEADLLVGADGIHSAVRKVFVPTHSLQWTGDILFRSTFDKALVENIEGLPEDAVFHCGPNENFLFTSRLGKTQYTVVGQTQSDPDDPENPYRTAKWNTEGDVTKLRDLYKGWHPTVQNILNATPSTRLYPNHLGTSLKSMVFESHVALIGDAGHTHGGAFAAGGSLAMNDAHALALALAHVWPTEKDTKPSRRQLERALALFDGTRRPHVNKLIELVEIGLAARQAKLRDARKVEETDKELRERISGLSDIAWLAEHDVEAAFWDFTQTEVAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7I3</accession>
    <name>A0A0G4P7I3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipopolysaccharide-modifying protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S007g000233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P7I3"/>
    <dbReference type="STRING" id="1429867.A0A0G4P7I3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF22">
        <property type="entry name" value="CAPSULE ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="1">
        <location>
            <begin position="298"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL22252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="605" mass="69656" checksum="3EE95F5AE6D32CE5" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7Q3</accession>
    <name>A0A0G4P7Q3_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-xylose reductase [NAD(P)H]</fullName>
            <ecNumber evidence="2">1.1.1.307</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S007g000339</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>xylitol + NAD(+) = D-xylose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>xylitol + NADP(+) = D-xylose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27445"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.307" evidence="2"/>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P7Q3"/>
    <dbReference type="STRING" id="1429867.A0A0G4P7Q3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000015">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="10">
        <location>
            <begin position="34"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="9">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL22358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="281" mass="31272" checksum="390DED7397DFF4EE" modified="2015-09-16" version="1">MAKLTLQSKHQLQSGHEIPVIGYGVYMIPSSATEKATLEALNVGFRHVDSAIMYRNEKPCGKAILNSNLDRSQIFFTTKIPPGSMGYESTKRAINSSLREAAQEYFDLILIHAPYGGKEARLGSWDALVEAQKAGKVKSIGVSNYGIHHLEELEAYIQGGGGGQIDVGQYELHPWLDHSDIVEWLQKRKIVVEAYSPLAHGSRLTEPVLLSIGNKYGKTPAQVLIRWSLQMGFVPLPKSTTPKRIRENADVFDFELADEDMKLLDTGEYSPTDWDPTVDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P847</accession>
    <name>A0A0G4P847_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione S-transferase kappa</fullName>
            <ecNumber evidence="4">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S007g000448</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GST superfamily. Kappa family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="4"/>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P847"/>
    <dbReference type="STRING" id="1429867.A0A0G4P847"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000096">
        <property type="entry name" value="Glutathione S-transferase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051924">
        <property type="entry name" value="GST_Kappa/NadH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014440">
        <property type="entry name" value="HCCAis_GSTk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943:SF13">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006386">
        <property type="entry name" value="HCCAis_GSTk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="6">
        <location>
            <begin position="5"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006386-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL22467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="223" mass="25465" checksum="416B5FB1BD817155" modified="2015-09-16" version="1">MPGKIDAYVDCVSPYSYYATLYLRKNRKALESHGVEVEFHPVFLGGINVGSGNKPPWTLPAKAAYSKFDSARACKYFGVPQIETPEFFPILSILPQRCMIYIKGHFPREKYETTFLSLWEWMFYKGIDISKPEKLAEVFQSNEFSDSEVREILAAAASPEFKQALTANTQTALDKGAYGAPWFWVRNADGKEEPFFGSDRFAFMWMYLGLPFQDVAIVEKSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P913</accession>
    <name>A0A0G4P913_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Adenosine/AMP deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S008g000198</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6)-methyl-AMP + H2O + H(+) = IMP + methylamine</text>
            <dbReference type="Rhea" id="RHEA:16001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:59338"/>
            <dbReference type="ChEBI" id="CHEBI:144842"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:16002"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P913"/>
    <dbReference type="STRING" id="1429867.A0A0G4P913"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000033">
        <property type="entry name" value="Adenosine deaminase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF42">
        <property type="entry name" value="ADENOSINE DEAMINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="9">
        <location>
            <begin position="16"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL22769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="343" mass="38322" checksum="D43DC691B75C1853" modified="2015-09-16" version="1">MDDSKPVDQRFTKALPKIELHAHLSGSISRQCLHEIWKRKKEQNPNLNVEDPLVLMPPGKVDYTLETPRFFSTFSKLTYQLCNDLDSLVYATNSVLEDFLGDGVVYLELRTIPRASPGITQEQYINSVLDTTEKFRSRTKRMSVFLILAVDRGSMTAAEADEIVNLAIENKSRGVVGVDICGNPTKGDVSIYKEPFAKAKANGLGITLHFAETTASASASELSTLLSFQPDRLGHVIHVPDEIKKEIARRKLSLELCISCNVHAKMINGGFLDHHFGYWRHEDCPIALCTDDVGFFCSPVSNEYLLAAQHFGLSRTDLLDMCIKSAEAIFASEYYQGRIQGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P971</accession>
    <name>A0A0G4P971_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="10">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S008g000258</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="10"/>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P971"/>
    <dbReference type="STRING" id="1429867.A0A0G4P971"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04300">
        <property type="entry name" value="GT35_Glycogen_Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000002">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000003">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468:SF3">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE, LIVER FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10 11" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL22829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="743" mass="84805" checksum="D6118555CD015202" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBA1</accession>
    <name>A0A0G4PBA1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S010g000035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PBA1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL23597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="59" mass="6447" checksum="303FE4FE4A56B2A1" modified="2015-09-16" version="1">MSPAYHLPVFLPVMGLIASRGLSIWVSDALRIGLDEPLEQDGARGDDRKQLGSKLNTQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCD0</accession>
    <name>A0A0G4PCD0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-xylose reductase [NAD(P)H]</fullName>
            <ecNumber evidence="2">1.1.1.307</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S010g000404</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>xylitol + NAD(+) = D-xylose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>xylitol + NADP(+) = D-xylose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27445"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.307" evidence="2"/>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PCD0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PCD0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="11">
        <location>
            <begin position="52"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="10">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL23966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="356" mass="40290" checksum="E88C26151EA250A9" modified="2015-09-16" version="1">MAYFATRTARAAPLGKSFSPSRSKFVTRGLATRATSYTLNTGAKIPALGFGTFQDPDSQEETVSLALRKGMRLIDTARVYNVEEQVGKGIKKSGIPREDIFVGTKLWCNDYHPEDVERAVNDSLRDLDTPYVDLLLMHYPCTFKRGADRFPRDAEGRMIPGETTFVDTWRAMEDVIKTGKVKAIGVSNFSKGEIETLLEKTGTVPAVHQMEVHPYLQQKEFNKWLKEQGIHVVQFSPLGNMNDFYRQTGWSKEIAHMKRVIDQPIMKEIAEKYGKSTVQVVLAWGINSGRSVIPKSVVDWQVEQNLESDFELQPEDMAQISILDAKARFNDPSLDYEWRLYSDLEGIDGTVKGRTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCN8</accession>
    <name>A0A0G4PCN8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cation efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S011g000056</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PCN8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PCN8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000001">
        <property type="entry name" value="Metal tolerance protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000005">
        <property type="entry name" value="Putative Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
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    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="93"/>
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            <end position="160"/>
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            <end position="200"/>
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        </source>
    </evidence>
    <sequence length="391" mass="44252" checksum="97EBC94C78DEEC65" modified="2015-09-16" version="1">MSLLDDPLNLNQYKTTISEPKKNWVPYAFNDEKEKLTDFYKEQNEMIEGFLSAGEEERLKAEDEAQNGGKVKLAVRASFTVNFFLFVIQLYAAVSTGSLALFATAADAFMDLVSSIVMLITSRMSSRPKPYKYPVGRRRVETMGVIMFCALMTIVAVELIIESAKALAGGKTESEKLDIVPLVCVGVAIFSKFVMFLYCYGLRRYPAAHVFYIDHRNDLAVNGFGLIMSIVGDRFVWYLDPVGACCIALLILFSWASTAFENMWLIVGKCAPREFVNKCIYVTLTHDQRIQKVDTCRAYHSGQQLYVEVDIVMDPETKLRESHDVSQALQRKLEGLADVERAFVHVDYDYLHDVNEEHRPLYEIGGAKHSIRALVKRLWSKNKEPTDGTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCU5</accession>
    <name>A0A0G4PCU5_PENC3</name>
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        <recommendedName>
            <fullName evidence="8 9">Beta-hexosaminidase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S011g000106</name>
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    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
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        </reaction>
    </comment>
    <comment type="similarity">
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Hex-like_dom2"/>
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        <property type="entry name" value="HEX_eukaryotic_N"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GLHYDRLASE20"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
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    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012723435" description="Beta-hexosaminidase" evidence="11">
        <location>
            <begin position="16"/>
            <end position="572"/>
        </location>
    </feature>
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            <end position="159"/>
        </location>
    </feature>
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            <end position="523"/>
        </location>
    </feature>
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        <location>
            <position position="346"/>
        </location>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CRL24112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="572" mass="63832" checksum="BF57D96899C2AEC9" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCY2</accession>
    <name>A0A0G4PCY2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S011g000174</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4PCY2"/>
    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Csf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056779">
        <property type="entry name" value="Csf1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048636">
        <property type="entry name" value="Csf1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32085">
        <property type="entry name" value="PROTEIN CSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32085:SF3">
        <property type="entry name" value="PROTEIN CSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Csf1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21678">
        <property type="entry name" value="Csf1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Csf1 N-terminal" evidence="3">
        <location>
            <begin position="146"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="domain" description="Csf1 N-terminal" evidence="3">
        <location>
            <begin position="887"/>
            <end position="1190"/>
        </location>
    </feature>
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        <location>
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            <end position="3210"/>
        </location>
    </feature>
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            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="253"/>
        </location>
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        <location>
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            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
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            <end position="1280"/>
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        <location>
            <begin position="3110"/>
            <end position="3132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="584"/>
        </location>
    </feature>
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        <location>
            <begin position="1210"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1251"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="3117"/>
            <end position="3128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF21678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL24180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="3211" mass="359715" checksum="7BFBA424CED4103D" modified="2015-09-16" version="1"> </sequence>
</entry>
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    <accession>A0A0G4PDF8</accession>
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        <submittedName>
            <fullName evidence="2">Fatty acid hydroxylase</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PCAMFM013_S011g000327</name>
    </gene>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL24333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="411" mass="47043" checksum="896568E1CB9D37DD" modified="2015-09-16" version="1">MIYSVDAASIDEIPALLVGFLQPFLQNLILPSLLSLFYLFCTGSLFFDVVHYMLHRTNTSSHPLLRHLARIHRFHHLYFTRHMNFDDKYLWQNLVQALPLELGLQIFGTALGYVLATWATPTGAVWITQRHLWSMIGIQIIRTIVVVLLSGRDSNHLVYKTAPKDPNWIFAGPEYHALHHVYPDRYIGSFIKLFDWVWGTSYSVRGKRFVITGGNGAFGRAIVAELEQEGVQSIRSLKFGVDWDHQNFEKAIAALSACDVLILAHGTKGQDAVESNCNSTVRLVQLFKQNRPINETSPTLPEVWYVGSEIEFHPAFGNKELQRYSQSKRRFLPHARSFFDDADIIYRHIVPSAFQSPMGPAILSAGWAARCTMFWIRRGARYVPVTYTGFAYLNYFKFMYLVPYAQGKDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDY1</accession>
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        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S012g000116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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        <location>
            <begin position="443"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="481"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="495"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL24507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="610" mass="67271" checksum="DB0FE38C3BD9D6FE" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PFF3</accession>
    <name>A0A0G4PFF3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S013g000274</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL25031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PFF3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24141">
        <property type="entry name" value="2-5A-DEPENDENT RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24141:SF1">
        <property type="entry name" value="2-5A-DEPENDENT RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="97"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL25031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="150" mass="16704" checksum="88B19996CFA57C5A" modified="2015-09-16" version="1">MLMKYDDTRKPGLWLRMLGITERVKMKDFCNHTPITYAVKEGHADVVGIFLRSKRVSPKARNGYKELLFHEAVKSGKCDIFQVFLDHGVPVNPRGGDGKRALHLAADTRNYEMARLLLQNGASTKIKDSIGKKASRPPKAAVAAPPEYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PFH1</accession>
    <name>A0A0G4PFH1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA methylase, N-6 adenine-specific, conserved site</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S013g000327</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL25084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PFH1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016445">
        <property type="entry name" value="Rog1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF62">
        <property type="entry name" value="LIPASE ROG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005412">
        <property type="entry name" value="UCP005412_abhydr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF676" evidence="4">
        <location>
            <begin position="302"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="DUF676" evidence="4">
        <location>
            <begin position="465"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="260"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="335"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="655"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="859"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="957"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="861"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="962"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1017"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1038"/>
            <end position="1047"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL25084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1058" mass="115989" checksum="D79B81E69FCC1403" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PFK0</accession>
    <name>A0A0G4PFK0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pyruvate dehydrogenase E1 component subunit beta</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S013g000316</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="10"/>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL25073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PFK0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PFK0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000006">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PDHB_mito-type"/>
    </dbReference>
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        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006667">
        <property type="entry name" value="PRK09212.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PRK11892.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624">
        <property type="entry name" value="DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624:SF96">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="9 10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="11">
        <location>
            <begin position="50"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL25073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="376" mass="40471" checksum="1F2B6F190F5702D5" modified="2015-09-16" version="1">MSAPRLFRPTARLFSSRLASTALRSNLRQTACAPSILRRGYATENGTKQVTVRDALNEALAEELELNQKTFVLGEEVAQYNGAYKVTKGLLDRFGPKRVIDTPITEAGFCGIAVGAALAGLHPICEFMTFNFAMQAIDQIINSAAKTHYMSGGIQPCNITFRGPNGFASGVAAQHSQDYSAWYGSIPGLKVVSPWSAEDAKGLLKAAIRDPNPVVVLENELLYGQAFPMSEAAQKNDFVLPIGKAKIERPGKDLTIVSVSRCVGQSLTAAAELKQKYGVDAEVINLRSIKPLDVETIVASLKKTGRIMVVESGYPMFGLSSEILALSMEYGFDYLTAPAVRVTGAEVPTPYAAGLEAMAFPQEDTIVSQAAKLLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PFV8</accession>
    <name>A0A0G4PFV8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aminotransferase, class-II, pyridoxal-phosphate binding site</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S014g000087</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PFV8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PFV8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000008">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000014">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF51">
        <property type="entry name" value="MANGANESE RESISTANCE PROTEIN MNR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="912"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="335"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="487"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="123"/>
            <end position="141"/>
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    </feature>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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</entry>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF223">
        <property type="entry name" value="CYTOCHROME P450-DIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL25721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="338" mass="38714" checksum="39E6B2EF93C33379" modified="2015-09-16" version="1">MQGKSIQKGIPIQEILQRYSSANLLCCIFDCPELGSQMMSMEHDVLLHTTQLTLKRYLFRPIFMNFPVLDRLASVIPSRAKARRLIRQFSELLQAEVIPSSGKKLQNGENENCLGDRLRSAWRDGTLNTKQLRDNLNVLYVAGQENPQLLMVSSLYLLGKHSEIQEYLREKINDLSISNLDDLDWRSLPYLTATILECLRLLPPISQLVNRHVAEPACLGGRMHIPRGTYIGYNSYATNRDPVAWGPDANNFRPERWGSTDEQISRKYRSAKARAEFISFHGGSRACLGEKFALLQMRVSLFVLARTFRWELDPEWKDQMTPAGPLHPRGVRLVFIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PI65</accession>
    <name>A0A0G4PI65_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EF-HAND 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S016g000174</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793149">
        <property type="protein sequence ID" value="CRL25893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PI65"/>
    <dbReference type="STRING" id="1429867.A0A0G4PI65"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040250">
        <property type="entry name" value="Nucleobindin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237">
        <property type="entry name" value="NUCLEOBINDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237:SF20">
        <property type="entry name" value="NUCLEOBINDIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195565" evidence="2">
        <location>
            <begin position="22"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="89"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL25893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="202" mass="22872" checksum="4F7962FC57D376D1" modified="2015-09-16" version="1">MVTKLFGFAAGLLALSGLASAHGSHSNDEAPSDDWATRHMIEEHHIGSFDPTSFFILHDYDSSGTWTQDEVRKTYGLNDESNAAVSEDKKQDAVRAVFELFDTGNTGFIDREDWLAGLAAGKRLPDLGYGPGHHGDLEYEYEIHHFEKYHGDDTTEEDLTHPEDIEHFRKHDEEEDAAIALEKLEQIQVVVDNIPQKFRRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PIH9</accession>
    <name>A0A0G4PIH9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molybdenum cofactor sulfurase, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S017g000208</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793150">
        <property type="protein sequence ID" value="CRL26225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PIH9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PIH9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="MOSC" evidence="3">
        <location>
            <begin position="259"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL26225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="469" mass="51795" checksum="344AD802E6F5E4A0" modified="2015-09-16" version="1">MLLQFVQYLQPILRDSMVFYGAIPLTLLLGLALAVVTRSGNTYTTNRELRHLQRLGLTTSNMADQFDPKFSAPNGTPIDGPARIKAIYLHPIKSCGPVEVNSALLTKTGFMHDRCFAFATELVKGDTVEASKGKFISQRTKPNMSLIKTELWLPHKGSNPYDQLVRAGGCVVLSFPDPDISRWSNRLETIFHSWKPFAAPQISFIAPLQVTAAQIDEFQVKMKTFSIHHRDATGLDMGKIPSVAIALPKLKKFLKIPEGQNLTLLKCTPDTLARTDRNLAPLKHIGSPAVHGYTDQQPININSLSSVHAVSRLLPPENQPLNALRFRANIWITNVPEFAEETWKRCRILSKSASMGPRASVSPSLSVVCRTSRCTIPNVNPDTGTFDADTPLPQKKRGRPQPSTTLVEYRTVETGNKMALGYIGVHCVPEDESLGKAEEQKAALYVAVGDEIEVLERGVHLYGSTGNDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PIQ5</accession>
    <name>A0A0G4PIQ5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Patched</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PCAMFM013_S017g000288</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793150">
        <property type="protein sequence ID" value="CRL26305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PIQ5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PIQ5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015918">
        <property type="term" value="P:sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000008">
        <property type="entry name" value="NPC intracellular cholesterol transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000029">
        <property type="entry name" value="Putative Patched sphingolipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004765">
        <property type="entry name" value="NPC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053956">
        <property type="entry name" value="NPC1_MLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032190">
        <property type="entry name" value="NPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00917">
        <property type="entry name" value="2A060601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727:SF2">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22314">
        <property type="entry name" value="NPC1_MLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16414">
        <property type="entry name" value="NPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="12" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195381" evidence="16">
        <location>
            <begin position="23"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="602"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="639"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="669"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="721"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="746"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="830"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1072"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1102"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1131"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1174"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1215"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="17">
        <location>
            <begin position="597"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CRL26305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1275" mass="139962" checksum="EBA08B39A3DF875E" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJ99</accession>
    <name>A0A0G4PJ99_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S018g000102</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJ99"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJ99"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013311701" evidence="10">
        <location>
            <begin position="16"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="11">
        <location>
            <begin position="317"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="183"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="279"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL26409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="544" mass="57011" checksum="C43B65D014FD12EE" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJG2</accession>
    <name>A0A0G4PJG2_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Elongation factor 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Eukaryotic elongation factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PCAMFM013_S018g000245</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJG2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJG2"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000076">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.990:FF:000001">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000193">
        <property type="entry name" value="Probable Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040533">
        <property type="entry name" value="EF3_4HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047036">
        <property type="entry name" value="EF3_4HB_sf"/>
    </dbReference>
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    </dbReference>
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            <end position="226"/>
        </location>
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        </location>
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        </source>
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        </source>
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        </source>
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        <source>
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        </source>
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        </source>
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        <source>
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        </source>
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        </source>
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        <source>
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        </source>
    </evidence>
    <sequence length="1067" mass="117244" checksum="21741E2EC098A77C" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJK6</accession>
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        </submittedName>
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            <taxon>Eurotiales</taxon>
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        </lineage>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL26328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="668" mass="73404" checksum="B8D8431C4C3EA148" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PK22</accession>
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        <submittedName>
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        <name evidence="2" type="ORF">PCAMFM013_S018g000209</name>
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        </lineage>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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                <person name="Abraham A.L."/>
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                <person name="Silar P."/>
                <person name="Lacoste S."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
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        <property type="entry name" value="AMIDOHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G01480)"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
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    </dbReference>
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    </dbReference>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <authorList>
                <person name="Cheeseman K."/>
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                <person name="Renault P."/>
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    </dbReference>
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    </dbReference>
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    </evidence>
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        </source>
    </evidence>
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</entry>
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    <accession>A0A0G4PLJ0</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="6">NADH dehydrogenase [ubiquinone] iron-sulfur protein 5</fullName>
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        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase 15 kDa subunit</fullName>
        </alternativeName>
    </protein>
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        <name evidence="17" type="ORF">PCAMFM013_S021g000173</name>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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                <person name="Giraud T."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
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    <comment type="subunit">
        <text evidence="5">Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFS5 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793154">
        <property type="protein sequence ID" value="CRL27258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PM50"/>
    <dbReference type="STRING" id="1429867.A0A0G4PM50"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24141">
        <property type="entry name" value="NDUFS5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019342">
        <property type="entry name" value="NADH_UbQ_OxRdtase_FeS-su5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15224">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15224:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="14"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR619342-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CRL27258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="103" mass="11317" checksum="142D6B2DB298F5BC" modified="2015-09-16" version="1">MASGYGNNGGPGRCYPFWQEVLGCYVVNSGDGASGKKKCVPALDDYYECLHHRKEALRTMKMQAAYRKAEAAHPRENAPKAEQIRSLGLLGKEEEAANVLSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PM61</accession>
    <name>A0A0G4PM61_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S022g000187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793155">
        <property type="protein sequence ID" value="CRL27507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PM61"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL27507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="51" mass="5882" checksum="55FB1D4EA1529052" modified="2015-09-16" version="1">MIGVYRLLIGRWDSRRAVTKISVEITRRVSCSMNIIPFPACSERIIDRGMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PM71</accession>
    <name>A0A0G4PM71_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase superfamily, zinc-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S022g000197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793155">
        <property type="protein sequence ID" value="CRL27517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PM71"/>
    <dbReference type="STRING" id="1429867.A0A0G4PM71"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C1773.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="13"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL27517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="345" mass="36816" checksum="CB60D5F88AF035C6" modified="2015-09-16" version="1">MSSHTVLRHTTRDSWKNIQTFVEPRPIVGKHEVLIKVRSVSLNYRDVAIATSKYPFAVKDNVVPGSDAAGDIVEVGEGVSGFAKGDKVVAAFDPATLYGPIKTWQTGLGGPTDGVLREYITIPAQSVVRIPESSTLSYAQWASVVCTGVTAWNALYGNVALKPGQTVLFQGTGGVSVTGVVLAKAAGAITIITSSSDEKLAYVKEKYGVDHVINYKKTPDWAAEAQKITSGQGVDFILENGGSGTMKQSLEAIAYGGIISCIGFLSLASQDQMPDVALLALGKGAVVRGIMVGSKEMLEDAVRFISKQNLQIPVEKVFKFDRDEVIKALDFMTGGQHIGKICIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMF9</accession>
    <name>A0A0G4PMF9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S023g000002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793156">
        <property type="protein sequence ID" value="CRL27544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PMF9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PMF9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL27544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="154" mass="17321" checksum="88618F6BDE4AD47A" modified="2015-09-16" version="1">MTATFPHQSKDQQSAMEEIVDIVRQIGRQQGANVYFRTCYALFKHLQDKAEQASEDLLHLHQSGAFGFSDDEFYLVYQVAQELQISVHDLADQALKAQLACEEFCELDPSYSAREAFKFTDTVQTAGKSEADASQGVCDSPRSMQFIMLPVNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMH2</accession>
    <name>A0A0G4PMH2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Micro-fibrillar-associated 1, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S023g000100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793156">
        <property type="protein sequence ID" value="CRL27642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PMH2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PMH2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033194">
        <property type="entry name" value="MFAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009730">
        <property type="entry name" value="MFAP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15327">
        <property type="entry name" value="MICROFIBRIL-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06991">
        <property type="entry name" value="MFAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Micro-fibrillar-associated protein 1 C-terminal" evidence="2">
        <location>
            <begin position="150"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
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        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
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        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="420"/>
        </location>
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        <location>
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        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF06991"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL27642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="482" mass="55578" checksum="1B817B2277155834" modified="2015-09-16" version="1">MPPPFPSSHRGMTKNPVRPARYRPGKAIAEEPSSEEEEEEEENDEEEREARREQERRRRAEALRRAKAPKASSFPASAVADQKVEEDDDEEGFVTEDEEDDKPAPAPAPKAVPHPTDDLKPTVSTTAAESDDEEEEEEEEEEESSEEESSSEDEAPRRMLIRPTFIKKDKRNTTGTAAGQTQAQADAARAAEAETQRAAQRQEKADQLIRDQLEKEAIARSSANRAWDDDELVEAEDEEAIDDTDGLDPEAEYAAWKLRELKRVQRSREAIEAHEKEIEEIERRRNLTAEEREREDSEFIAQQKEDRDAARGQTGFMQKYYHKGAFFRDDLEAEGLDRRALMGARFEDDVNRDTLPQYMQVRDMTKLGKKGRTRYRDLKSEDTGRFGDGLENRRRRDGPPQGVTDERFMPDRRGGDDGDRGPTGANASVVRPRRMSRSRSPRRDRRDDRDSSRVERSRSRERRKRSPSPYDDREKRRRVDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PN61</accession>
    <name>A0A0G4PN61_PENC3</name>
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        <submittedName>
            <fullName evidence="9">Nitroreductase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S024g000095</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nitroreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793157">
        <property type="protein sequence ID" value="CRL27840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PN61"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02140">
        <property type="entry name" value="Frm2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.109.10:FF:000001">
        <property type="entry name" value="Nitroreductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="entry name" value="NADH Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033877">
        <property type="entry name" value="Frm2/Hbn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43035">
        <property type="entry name" value="FATTY ACID REPRESSION MUTANT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43035:SF3">
        <property type="entry name" value="NITROREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="66"/>
            <end position="239"/>
        </location>
    </feature>
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        <location>
            <begin position="32"/>
            <end position="54"/>
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    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL27840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="263" mass="29412" checksum="CCD0DEB646C4AD09" modified="2015-09-16" version="1">MAARLIQSPLNAITRAALSRTSPTRLVHLYRTQSHQTTPRPFSSSTRKSAPTPAANMSSALIDLAKNRRTIYQLGKKSPVPDSKIEELVNAAILNVPSAFNTQSTRLIVLLHDQHDRLWDIAIEAFEGLVKAGKIPQEVWEKQTLPKLLGFKGAYGTILFYEDPAHIKPMQEKFATYKDNFLPWADHSNAMHQYFLWTGLEALGFGANLQHYSPLIDAGVAKQWDLPSEWRNVAQLVFGSPEGAAGEKVQKPVEERVKIFGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PND6</accession>
    <name>A0A0G4PND6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S024g000150</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793157">
        <property type="protein sequence ID" value="CRL27895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PND6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PND6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL27895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="611" mass="68855" checksum="C93D8918B4C7BE79" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNZ3</accession>
    <name>A0A0G4PNZ3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Delayed-early response protein/equilibrative nucleoside transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S024g000086</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793157">
        <property type="protein sequence ID" value="CRL27831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PNZ3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PNZ3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034257">
        <property type="term" value="F:nicotinamide riboside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF88">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016379">
        <property type="entry name" value="ENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01130">
        <property type="entry name" value="DERENTRNSPRT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL27831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="455" mass="49748" checksum="283B18D335600506" modified="2015-09-16" version="1">MNRIRSLIARPAAYERLQDSAADDADETTYTERHQQSPFSRLQYGIFFLLGVSMLWAWNMFLAAAPYFYSRFQSDDWTRLHYQPSIQSMSTVTNLGAAYALAKLQKNASYPRRITFSLLMNSVVFTILAFSAVVMTDSSPRAYFGFLMVMVCAASLATGINQNGVFAYVSGFGRDEYTQAIMGGQGVAGVLPGIVQIFSVLAVPPKEDRVSPDQDQDQSSSMPQTSPSKSAFIYFLTSTGVSFIALLAFLYHLRQQPSSRQKLSTDDDESIADDREHSKTVSLRTLFVKLRFLAFAVFVCFLVSMVFPVYTAEIQSVNDPASSRIHDPSVFVPLAFLIWNLGDLAGRMCVAIPGVSLGQHPQMAAIVAIARVVFIPMYQLCNVNGQGAAVNSDIFYFLVQFFFGATNGYLGTSCMMGASHWVVADERPAAGGFMSLVLVGGLAAGSLLSFSVASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PP35</accession>
    <name>A0A0G4PP35_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S026g000015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793159">
        <property type="protein sequence ID" value="CRL28150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PP35"/>
    <dbReference type="STRING" id="1429867.A0A0G4PP35"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL28150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="307" mass="34828" checksum="D85700930CB92FC9" modified="2015-09-16" version="1">MPADKIRVSGDSRIEYKTATLNGHNYSYILSQPKSGQYKATVFLIHGFPDLSMGWRYQIPMLVDMGLRVVAPDCLGYGRTDAPDDFTPGAGLAYRIALWHPELVSHLFTVCVPYARPMAKNISIEDLVRNVTPHFAYQLQLKSGEVEKVIRSKDEIRQFLLALYGGRTEAGEPGFDAHKGVLFDKIGHLKPSRLLSEEELEFYTNEFARSGVHGPLNWYRTRDVNYKDELAILDREIQIPTLFIQALRDQALPPQLGKSMAKQFPRLTLKQVNTSHWALWEKPEEVNEIIGTWLKDQSVADGRAGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPB9</accession>
    <name>A0A0G4PPB9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S026g000157</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793159">
        <property type="protein sequence ID" value="CRL28292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PPB9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000286">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000308">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="58"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL28292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="450" mass="49004" checksum="5950BB29886205EA" modified="2015-09-16" version="1">MNTNTNESSSPSSWPPTPDDPGYQYTPEATPSETDETPPLHAVNVAPRWNESKTTIWKVTATFWCAFVMGANDAAYGAIIPYLEVYYQKNYTIVSLVFLSPFVGYTVSAILSNLIHQTLGRRGITIIAPTCHVIAFAVISTHPPFPVLVIMYILVGLGSGFHNAAWNVWIGNMANSHEVLGFFHGFYGVGATISPLVATSLIIKAGWEWYSYYYLMTGAAVIALVYSTSAFWAETGSKYQEENPSFPGRGGVFAQTRLALTYKVTWICAVFLFLYGGIEVAIGGWIVVFMTKVRHGDPFESGMAETGFWLGITVGRFVLGFVSPRIGEKLSIAIYILLSMALELIFWLVPEFIVSAVAVAFVGFFMGTIFPGVVIVATRLLPKNLHVAAIGFAAAFSMGGGAVFPFMIGAIAQAKGVMVLQPILLAMLAVSLGIWAMVFRLPQHEVSHQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPC5</accession>
    <name>A0A0G4PPC5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S025g000111</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793158">
        <property type="protein sequence ID" value="CRL28053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PPC5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PPC5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041:SF6">
        <property type="entry name" value="FORMYLMETHIONINE DEFORMYLASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="576"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="672"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL28053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="688" mass="75533" checksum="2B28BE84AC63F681" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPE1</accession>
    <name>A0A0G4PPE1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cellulose-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S025g000126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793158">
        <property type="protein sequence ID" value="CRL28068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PPE1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PPE1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048527">
        <property type="entry name" value="Sde182_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011483">
        <property type="entry name" value="Sde182_NH-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21027">
        <property type="entry name" value="Sde0182_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07632">
        <property type="entry name" value="Sde182_NH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cellulose-binding Sde182 nucleoside hydrolase-like" evidence="1">
        <location>
            <begin position="15"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Cellulose-binding Sde182 C-terminal" evidence="2">
        <location>
            <begin position="373"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL28068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="55462" checksum="47B2924D129EF2A6" modified="2015-09-16" version="1">MASSPQFQSFPSMPRVFILSDISNEPDDAESLVRYLLYSNQFRTEGLVACTSTWMKSKVCPQDMHKIVDGYEKVVGNLNVHAHPDDPYPTAQYMRSLIKRGAETYGMAAVGDDIPLSEGGQLLLERIQAPTSDPLWVLCWGGTNVLASVLLKIQNSHSKADAVALRSKLRIYTISDQDDSGVWLRTTYPDLFYICSVHGWNQYGMAAWTGISGDKWYGFDKGGPDPSKISKEWIRENIQIGPLGSTYPDFMFIPEGDTPTFLYLIQNGLGVAERPEFGSWGGRYILTDISGRYGKHGHYSDTPDEVDGLDGRSHKSNQATIWRWRDAFQTDFAARMQWSLTSDIGKANHHPVAVVNGTKGPAPLMFELEAGSKFQLDASASYDPDPNDSLSFKWYQYKDPSATQWSVHHEVGELGIRPLDETGSVVEVTLPPPEKCCVELISRKAIQKGQLLHLILEVKDNGSPALITYRRVVIQVTNEKLLGGGGGADAIGDTMKDVMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRN3</accession>
    <name>A0A0G4PRN3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S032g000108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793165">
        <property type="protein sequence ID" value="CRL29072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PRN3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL29072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="55" mass="6113" checksum="ADF9E10A5C1821BE" modified="2015-09-16" version="1">MPPVHNSLIGYHLTASFIAGAIYKTIIAISRLYRVWKTGLPVRSAVLKPIILHSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PSZ6</accession>
    <name>A0A0G4PSZ6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S034g000076</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793167">
        <property type="protein sequence ID" value="CRL29278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PSZ6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PSZ6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF23">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="21"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL29278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="479" mass="51169" checksum="381A08C8C97B6F3A" modified="2015-09-16" version="1">MEDIISRKPWLFDLRSSKQLIGLAVFSTTFTDGFLYGIIVSVLPFSLTVRSGVPEADVPFWTSTSLAVFGLAMVLGAPIAGWIVGKCERRQIPFLGGLSCAFGATILFMLGVKPWVIIVARVFQGLSAGVVYTAGLTLLVDTIESHELGPWIGFGLSGMNFGVLVSPTLGGIIYEKAGFYPVFIMGLGVVLINLILILLMIDRKTAAKYRGHNDSTKSSSLPNGNSPKSAIANGKRRLSNVEEGDSNITTPLLSRCRETSSAVAKDPSWWTIVGGFLRNHRIFAALYGCLINTILVSAMDAVLPIFIKQTFHWFSGATGAMFLNLTIPSLIGPFVGMISDKYGVRLISGLGFTLAAVAVALLALIQHDDTTNKVMACVLLSFVGIGLSTSLTPLVAEIPRIVNTVQEEQPDIYGDKSAVTEAYMLLDAALGAGTVLGPLLSELAFENLGWTGCTAMLGFLSVSAIFPVMAHLVPNPKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUC3</accession>
    <name>A0A0G4PUC3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Zinc finger, C2H2-type/integrase, DNA-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S044g000041</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793177">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PUC3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PUC3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transcriptional repressor protein YY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001289">
        <property type="entry name" value="Zinc finger protein 574"/>
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    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
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    </dbReference>
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        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
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    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="215"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
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            <end position="274"/>
        </location>
    </feature>
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        <location>
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            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
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            <end position="329"/>
        </location>
    </feature>
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        <location>
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            <end position="142"/>
        </location>
    </feature>
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        <location>
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            <end position="414"/>
        </location>
    </feature>
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        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
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        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
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        <location>
            <begin position="389"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL30110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="470" mass="52336" checksum="F289E847AE0D4395" modified="2015-09-16" version="1">METAEPVSYEFPGHAVGAFAHRRPMDSTLSQNFPFYSPQTAPYSLPYQTPSSLPYSFGHSVGHTHAHSNPYHQYFVPSQHPIQPQPLRLTTEQPLQSLPEIRPAKNAISQTVKSTPDHGPRPLSTEGHNSPVGPNETKQTPDDIAFSTNVDVLMKAIQAKHASSPTQQSLPPLQHLAAPAPQAYPVSYPTASPTPPRCYHANEGQLSRSGKKRKYNCNLPGCGKSFAQKTHLDIHIRAHTGDKPFICKEPSCGQRFSQQGNLKTHQRRHTGEKPFQCEICHKRFAQRGNVRAHKLTHDQSKRFDCRLDECGKQFTQLGNLKSHQNKFHAATLHNLTVRFSQMGENGAMNMNAADRELWVYFAGLYKNSNKGIKGRGKDRRISTTKRSDAQSSCGSMDRTQSVESEEGVSKMQMQMQMRRGSLEDGFSVYNASSSDGDDGEPYYIDRRAHVHGHGHGHGNSHGHGHIHHGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PV01</accession>
    <name>A0A0G4PV01_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S046g000057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793179">
        <property type="protein sequence ID" value="CRL30253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PV01"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL30253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="50" mass="6074" checksum="67D6F438448FDA4F" modified="2015-09-16" version="1">MLRDGNFVYITYLAQLLACLRFNYQYIHRIYPEKKSGLPDHFFDLFSELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PV70</accession>
    <name>A0A0G4PV70_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S043g000032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793176">
        <property type="protein sequence ID" value="CRL30037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PV70"/>
    <dbReference type="STRING" id="1429867.A0A0G4PV70"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195647" evidence="1">
        <location>
            <begin position="20"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="261" mass="27565" checksum="C5C8C780E996E2EC" modified="2015-09-16" version="1">MRLQSTAAVSLLFTVGTSARSIIHSGQGFGTYYYDIGQVDHCGTTFEYQNKGGVMCNSAALLSLDEMNTNYVVAMNNTQLGTAPSVYCGKRVVVSVNGQQSDLQLFIGDGCQRCGVGSSLSDIWDAEGAPGLDFSYTVLNELSGGNACKAGHVAISWEILDETIHSFHGSSSSFDSLSEPKSPNAAAAKSFTQCPDQTETPATMTVGTSATQDTPFSIACSENAWQCNGAVLEQCISTIWTPRVTCTAGYNCQGGSNPYCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVI6</accession>
    <name>A0A0G4PVI6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alcohol dehydrogenase superfamily, zinc-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S051g000001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793184">
        <property type="protein sequence ID" value="CRL30398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PVI6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PVI6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="10"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL30398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="331" mass="35797" checksum="BB1AD5E6F673D1CB" modified="2015-09-16" version="1">MSVTFEVFRGSKEGKIVADKTTRTLQPNEVYIETTHSGLCGTDEHYLCSGMALGHEGVGIVRQLGRDVTNVQVGARVGYGYTHYVCGNCAKCLTGWDQYCENKKEYGSHDHDLGSFGGGVVWDAGCVVPIPEGYDSGDAAPLMCAGATVWTCLTEYGVKPTDRVAIMGVGGLGHLAIKLASAMGCHVVVLSSSEAKREEAFGFGASEYHVFRQGEELKDFKPVNHLLLCGSANVDYPSLIPLMDVHGSIYPLTVDFAPSPVPLLFMNLKGIRIQGSLVASRKSLRTLVEFAADKKISPTTMTFPLTKDGVETAMQTLRDGKMRYRGVLVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PW26</accession>
    <name>A0A0G4PW26_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutathione-dependent formaldehyde-activating, GFA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S050g000006</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793183">
        <property type="protein sequence ID" value="CRL30359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PW26"/>
    <dbReference type="STRING" id="1429867.A0A0G4PW26"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF8">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="26"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL30359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="179" mass="19527" checksum="50D3F534EF33DC52" modified="2015-09-16" version="1">MSTDKSKPYIPLAGGAKDGWSEEQEATATCYCGAIQLAFPTEGPGLIDTFLCHCTDCRKITASMFASNFIIADSHLRHLRGRENLTSYGQSGTIGSGKKMTNFFCSTCGSLMYRVGEAFPGHSILRLGTVDDFNLHETKLRPRIEQFTNDRVGWLHHVEGVGQVGGTAYSPKKEPSSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PWJ0</accession>
    <name>A0A0G4PWJ0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GPR1/FUN34/yaaH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S054g000012</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793187">
        <property type="protein sequence ID" value="CRL30555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PWJ0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PWJ0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047622">
        <property type="entry name" value="GPR1_FUN34_YAAH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038013">
        <property type="entry name" value="AceTr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01114">
        <property type="entry name" value="GPR1_FUN34_YAAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="304" mass="32250" checksum="A84F05F4A408F782" modified="2015-09-16" version="1">MSGTEAINHAELEKDVGPSHSPQNGLGNGNNGAPMQPQLSAEEHQVARAAARFGYGPLAHVNTTEASLPPFGGEFQPGLYKSVEGRKFANPAPLGLCAFALTTFVLSAINMGTLDIASPNIVVGLAFGYGGLVQLLAGMWEMAVGNTFGATALSSYGGFWIAFAIVLTPGGFQIGEALGESSSDASKFYDSMGLFLMGWFIFTTIMLFCTLKSTVAFFMLFFTLDLTFLLLGVAYLQRGPDGHPNANVQKAGGFFGFLAAFAAWYNALAGIADTSNSFFIIPVAHFPWSPTGRVRRGKTDRELA</sequence>
</entry>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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    </dbReference>
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            <end position="912"/>
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        <location>
            <begin position="1"/>
            <end position="729"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
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        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
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            <end position="73"/>
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            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
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            <end position="180"/>
        </location>
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        </location>
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        <location>
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    </feature>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20994"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL30558.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="919" mass="99651" checksum="AB70D92A1A02DF74" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155:SF1">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155">
        <property type="entry name" value="A-KINASE ANCHOR PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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    </feature>
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        <location>
            <begin position="131"/>
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            <begin position="160"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="374" mass="42555" checksum="6F7CD296BEA1CE55" modified="2015-09-16" version="1">MSHHDYVDAESRNRLPTLFEVLSRRTLAPVDLFSFYIYMRDQQRSVDYLDFWLDVSQHMLLCRHYVRELRRSVLVATPDMERADSKRSSAMLDNLENLGDIPLTEAGPSRLRGFQENEKDRDADQRLSAFLRSEGHTTSPSRQNSMGSSGESAHQISSFEDGRDTPDSRLNDSTSPGHTVARNDIRASAEKILYTYLLPGSEREIMLPETMVSTIINLVEDDGRDDPEVFGPAKDYVFQAMERDAFPGFLQAKALGNMVPLSIILRLAFALISFGGGFWAAFYVVLRNKPRNIRCWIILPFAVAAYFIISYQYKIDPVMAFLGYSEYTFMNWAPIREPYVRKLLNKRALVTALIAFLTAAALSILFIFVPGVML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PWZ9</accession>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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                <person name="Silar P."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
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        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
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        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF67">
        <property type="entry name" value="PHOSPHOLIPASE_CARBOXYLESTERASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_5G09340)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="3">
        <location>
            <begin position="29"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL31022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="258" mass="27147" checksum="C4DE0EC3DF4609F3" modified="2015-09-16" version="1">MPTKTPTPSDFPSELTVTVTPAPPSPSQSTSPAPNILLLLHGLGDTAASFTKFAEAIRLPETTIVTVQGTAPLPFDLGGFHWGDDVSFDSATGALDMDAGLTRSTKILVSDVVRGTLVQKCGYALREIMVLGFGQGGMAALAIAREIGLKGNGNADSGEVGALSGVISIGAPYPLSGSRVGDKNRSPVLLVAGRDSVAVSDEAVRRTKQVFEFVEVSRYARKGDGMPSNREEMLPVMQFFARRLRSRQGVPEGSVEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PX23</accession>
    <name>A0A0G4PX23_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S061g000022</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793194">
        <property type="protein sequence ID" value="CRL30848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PX23"/>
    <dbReference type="STRING" id="1429867.A0A0G4PX23"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF26">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013017523" evidence="3">
        <location>
            <begin position="16"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="2"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL30848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="329" mass="36384" checksum="2CB921D26BEE5B22" modified="2015-09-16" version="1">MSRLIVILGITGVQGSSVADAYLSNPGWKIRGVTRNPASESSKKWEMNGVEIVKGDLDDVASLKQAFVGADVIFGVTDFWTIFKDPESHEKKKPSQSLVEYCHDVELQQGKNLADVAATVPGLSRYIFSSMAHAKNSSDGKFAELYHMDSKADAAIYAQSLPALAGKFSQVQAPIYFQLPWEWGLPTTPKKEVDGTWRMTGIGPGDKGIPFGHVRKDFGPCVRAVAESEPNVNLFAVGEYVSWSDYLRIFCETQGFKYGGYDELSYDKFCELLPGGLGHEFAHNVLFAHEFGYEGIDPAIVRPEKFGLKMTSFREYCQETDFSALNGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PY91</accession>
    <name>A0A0G4PY91_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S082g000015</name>
        <name evidence="2" type="ORF">PCAMFM013_S091g000007</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
            <strain evidence="1">FM013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793213">
        <property type="protein sequence ID" value="CRL31168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG793222">
        <property type="protein sequence ID" value="CRL31224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PY91"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL31168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL31224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="92" mass="10551" checksum="95C6B7613101F2E6" modified="2015-09-16" version="1">MSILPGNEQPIATVKNTCWEFYRRIGDKTKASLRRVIHRVFCLNFTALTMNGRVYFVTRLWLLEVARCTQRSLFEATAGECDEVDTASCQMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PYF9</accession>
    <name>A0A0G4PYF9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gluconate transport inducer 1/Pac2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S142g000001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIT1/WOR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793272">
        <property type="protein sequence ID" value="CRL31367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PYF9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="293"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="346"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="364"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="378"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL31367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="473" mass="51829" checksum="806BC235DFF7A65D" modified="2015-09-16" version="1">MVNGTAAVLEPTFTGYVATTQDALILFEACLTGVLHHVPRRPHDRERSHLVRSGSVFIYEENASGIKRWTDGVTWSPSRILGNFLVYRELDKPFPPGEKKRAMKKATRRPVPAGRPGEPYPRHDSSQGYSPTSPSSGPFTDRSSHQSELERALVGSLVDSYGFKDSGLVKKTMSVTVLGVTHHLVSYYSVEDVMRGILNPPSMVDSLRFIRPRTELTQKQSFRSPIDELEANAVEAQEPSHAALYGYRPQMMAPPTYAMPNPTNDFYMHPSPYAATHPPQQGPIQGYSMGAPMASQSAPNPYLPNPGQSTIPPKQEDYHAFRAGPYGGSMDSMSAHSMASIPGGINAGLPGSLNERNRSTSDHSPSAYRNSSISSRSQATDATSPMDPSTPATYSRGSFSMSGQMENQHPALDRNMPGLDPNVPRRESNPIHPSYYATDRSQYYVPAPYAATQPMPTWTTTAATQPQMAQPQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PYM0</accession>
    <name>A0A0G4PYM0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase superfamily, zinc-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S098g000005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793229">
        <property type="protein sequence ID" value="CRL31262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PYM0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PYM0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="1">
        <location>
            <begin position="3"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL31262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="216" mass="23724" checksum="A7134132279A5231" modified="2015-09-16" version="1">MLLCGSDRHIYRGTRVPQVPSDPIVVDHEAIGVISEVGSGVIFLSVSDSVVIPDCIDDGHLLLEPETNTTYGFAQPEVADISTLNSRQEPDYSSFEPGDTVAISVLVLLDYSQHTLLYFAELLPGGVRRSVDCVVYEAVNASRSPESDIVLRNMIEVTSVKWELLAFILRRFILIKVVDRVLSLCLWVTCGTRRCVLGPHHLSGATSRESIPNTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NT43</accession>
    <name>A0A0G4NT43_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Alkaline phosphatase</fullName>
            <ecNumber evidence="3 15">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PCAMFM013_S001g000196</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="3 15"/>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NT43"/>
    <dbReference type="STRING" id="1429867.A0A0G4NT43"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.60.40:FF:000002">
        <property type="entry name" value="Alkaline phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000063">
        <property type="entry name" value="Alkaline phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018299">
        <property type="entry name" value="Alkaline_phosphatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF5">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00123">
        <property type="entry name" value="ALKALINE_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 13 15" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="12">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="506"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CRL17236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="600" mass="65035" checksum="6C2790256CC10F22" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NU37</accession>
    <name>A0A0G4NU37_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zinc finger, C2H2-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S001g000556</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NU37"/>
    <dbReference type="STRING" id="1429867.A0A0G4NU37"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051701">
        <property type="term" value="P:biological process involved in interaction with host"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000606">
        <property type="entry name" value="C2H2 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000758">
        <property type="entry name" value="C2H2 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF32">
        <property type="entry name" value="ZINC FINGER PROTEIN RST2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="105"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="164"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="429"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="517"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="590"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="210"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="521"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="549"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="614"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL17596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="661" mass="71106" checksum="54A4D6D29ACF31AE" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NUE3</accession>
    <name>A0A0G4NUE3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ras small GTPase, Rab type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S001g000672</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NUE3"/>
    <dbReference type="STRING" id="1429867.A0A0G4NUE3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04149">
        <property type="entry name" value="Arf6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000832">
        <property type="entry name" value="ADP-ribosylation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041838">
        <property type="entry name" value="Arf6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="3 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="127"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL17712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="184" mass="20631" checksum="21CB4ECF11884967" modified="2015-09-16" version="1">MGGQVSKMMGKIFGTKEMRILMLGLDAAGKTTILYKLKLSNQDVTTIPTVGFNVESVTYKNVKFNVWDVGGQDKIRPLWRHYYSGTQGLIFVVDSSDTARVEEARSELHKIINDREMKDALLLVFANKQDIPGHLSPEEVTQQLQLTKLKDKLWYVAPSVATDGTGIFEGLAWLSNNVKTQPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NUN8</accession>
    <name>A0A0G4NUN8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S001g000757</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NUN8"/>
    <dbReference type="STRING" id="1429867.A0A0G4NUN8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF13">
        <property type="entry name" value="RTA1 DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL17797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="336" mass="37731" checksum="A5C9E3A93B6697CE" modified="2015-09-16" version="1">MLEARSSYQEGSLWFYAPNKGAAIAFAILFAISGGIHGYQCFKYNSWKVTGLLPWSAVLFTAGFIIRTIGAFGQWGNIGIYIASTVLLLVGPPVYEGANFFILGRMLYYIPYHSPIHPGRVATTFVALGVTIEIITANGAARIANTSGNSQNTGKAMLKAALIMQIALMVGFVALAGRFHFNCSRGGVLNRKIKHALLVLYCSCTFITIRTIYRTVEYFSAASLNTYTDLENISPVLKQEWFFWFFEVVFMYSNTTLLNVFHPMHWLPRSNKIYLAEDGVTEIEGPGYDDSRHWLQTLVDPFDIYGLIVSRGKKEKYWEANPTRREETTTRITQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NUT8</accession>
    <name>A0A0G4NUT8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sugar/inositol transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S001g000787</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NUT8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL18295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="230" mass="25677" checksum="F1FCE131F17FA372" modified="2015-09-16" version="1">MPSPSRGLSAVVHLVGLSSFLWSFKYMHENPNQANQAYGWHFQYLTVIGLSLSTLTFAVALLADITSSRRLFLIKNILSICSAPLEVVISVLYWGLRLIDERLVIPEDLFIPLHADISFHAAPSVVMLVDLLLLSPPWTITVLPALGLSSTIAFGYWFWIEQCFSQNGWYPYPIFEALPTSGRIGLFTLSALIMTLSTVTLKWLHGRVNGFGDPMKPESRPGDIKRKNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWU6</accession>
    <name>A0A0G4NWU6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Crotonase, core</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S002g000401</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWU6"/>
    <dbReference type="STRING" id="1429867.A0A0G4NWU6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000074">
        <property type="entry name" value="Enoyl-CoA hydratase (AFU_orthologue AFUA_2G10650)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF152">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G03410)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL18531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="272" mass="29480" checksum="C512C2D931ADBED7" modified="2015-09-16" version="1">MSLRSGPLKHENFFISFPHERVVQVTINRPDKLNCIDKTTSREIAKIWEQFDEDESLWVAIITGVGRAFCTGADLGEWNAMNKAGVVNDMSAPGLAGLPRRTGKKPIIAAVNGICMGGGFEMVANCDLILASSSAIFSLPEVKRGIVPVAGCLPRLTRTIGLQRTMDLVLTGRNVSATTLHDWGLISQVVDSPADVVRAAVEVAEVMCKNSPDSLIVGRLGVRMSWEAGSVEDTVSDLADQWYPRLVGGPNFAEGIQAFVEKRSPSWKNSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NX62</accession>
    <name>A0A0G4NX62_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Target SNARE coiled-coil domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S002g000500</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NX62"/>
    <dbReference type="STRING" id="1429867.A0A0G4NX62"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019529">
        <property type="entry name" value="Syntaxin-18_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959:SF0">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10496">
        <property type="entry name" value="Syntaxin-18_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="296"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="62"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL18630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="386" mass="42147" checksum="14FE69E81F191C72" modified="2015-09-16" version="1">MTDLTPTLNNLLSKQGSSIPQTRKPCTETADEFLKEAYRINSHIHSLLQYLQSIRHAYLSTTQPQRRQNTITPNPKNAPPTANAQTNLTDPERDAVDTSTALLLRDLATSIANLSSAESLRQETSSTLLHKKYGHSAAGALLWRWAGGGGALDSSSADNEGKSAEQIRAEESARSLATVRESVLWFLRRGLECAVGVQRRMVEKRIERVREKEKSVLYKVAAGKPAGGNGTGPRKGSFSVSERTGAGVGGSGAGSFDPTFQAPHAAVLSETDTARIEAQLSPEQLQLFAEENDSMLKHYEHTLGKVQNAEKSLLEISSLQETLVSHLATQEEHISQLVSDVDTTQTNVGQGNRELKRATERRSTAQAVFWGTVGLCTWLVVWDLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NX79</accession>
    <name>A0A0G4NX79_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S002g000597</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NX79"/>
    <dbReference type="STRING" id="1429867.A0A0G4NX79"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07383">
        <property type="entry name" value="MPP_Dcr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440:SF11">
        <property type="entry name" value="METALLOPHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="35"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL18727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="405" mass="45726" checksum="7A7FC5EE13177B58" modified="2015-09-16" version="1">MVPRPDLRASDQIVLKPPTDRTLRFREDGTFHIGVFEDLHFAEDEEKDKKSKKVMSNILEEEDIDFIVINGDLVSGERTQKADSKKYIDSVVSPLVNEGYSWASTYGNHDSEVNLNPKDDMFKAEQKYPNSLTQSRVSGDKAGITNYYLPVFSHGQANTSTPALLLWFFDSKGGHYYKKQGEDGPAVKRPSWIDESVVDWFTKTDSKLKKQYGKVIPSLAFYHIPAHAMLEHQQTRGINPRLTPGVNRERVNPQGTGPWSYDGQDVKFMDALLHTEGLIAGFSGHDHQNDWCFKWDGSLVDHNLTGNGINMCYGRHTGYGGYGDLLRGGRQILLHEGNLADDTETWIRLEDGSAQARVTLNTTYGQDPYLAVTNGAGKPDSYMQDSLLSLSWLWVPIMMLSRWRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXS7</accession>
    <name>A0A0G4NXS7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein-tyrosine phosphatase, SIW14-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S002g000659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NXS7"/>
    <dbReference type="STRING" id="1429867.A0A0G4NXS7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052840">
        <property type="term" value="F:inositol diphosphate tetrakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF48">
        <property type="entry name" value="INOSITOL PHOSPHATASE SIW14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL18789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="154" mass="17612" checksum="2599A86B2B5995E4" modified="2015-09-16" version="1">MVTERIHSRKATITGSEIPSRLFYRPARFFQSGERVNTIMQCACSLVIPMTDITPSNFRELVACAKYARKVYYIREEYNVVLIHCNQGKHRTGCVVACSRKLQGWEHSAIIDEYRLYAGQKARQLDEGFIRLYELGAISQIAYEANVAGWGRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYB7</accession>
    <name>A0A0G4NYB7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S002g000938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL19068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NYB7"/>
    <dbReference type="STRING" id="1429867.A0A0G4NYB7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL19068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="191" mass="20150" checksum="EC668E16C35A4AA8" modified="2015-09-16" version="1">MGLEQGISPQTASIINSDEAFDAIMAVNVNGVWNVGTEYLRYLLKTEEETHATTPTASGISLSIDPPGNDAGVSKVTASMVNVGSAISTHGFAGLAAYTASKHAVLGLTRAWIKDFASKGVRINCLAPGTTDTPLFRKCFTQEMIDEHCLPLIPMRRLASTEEIANGVIFLLGDQSTYVTGEVLGATGGFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZD5</accession>
    <name>A0A0G4NZD5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S003g000222</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZD5"/>
    <dbReference type="STRING" id="1429867.A0A0G4NZD5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF13">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL19431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="34480" checksum="FCF7CA8CC06A2CAD" modified="2015-09-16" version="1">MDCMFSKYSHGEDSRRESGERLLAEEEGTLWSGNETSAPVSTSFASCLLQLSALVLVFLLGTLFGFHWRGDLDGLCSRHVSHYSTVMKEVGIQYSLQEFNGSLLKENVFRQDAGPDVDAAWESLGVNYRSVRIPLEDAEQSGLAADQVKINAKYGGGFPANVEGLHHLHCLVCVLYPKPMLRMKYTNTDKNLLRQSLYYNYDYYHTRGEGPFTNNDYILRRHVSHCLDILRQELMCTVDSGVLGQVWIYPENPEPYVDFNTQHRCKNFDAVRSWAEENQLPQDPPSDFLQAPSEGDRIYSQMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZQ8</accession>
    <name>A0A0G4NZQ8_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ethanolamine kinase</fullName>
            <ecNumber evidence="3">2.7.1.82</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S003g000352</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.82" evidence="3"/>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZQ8"/>
    <dbReference type="STRING" id="1429867.A0A0G4NZQ8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05157">
        <property type="entry name" value="ETNK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF66">
        <property type="entry name" value="ETHANOLAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL19561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="412" mass="46169" checksum="FFB5B8E375FB38CA" modified="2015-09-16" version="1">MGSTETKAATPEFRYIPLSYNHADSQSSALRLILTLNPDWEGPGNNIEFVRFTDGITNTLLKIINLRPGLTEEQIDNEAVLMRAYGNGTEILIDRERETKSHALLASRGLAPPLLARFKNGLLYRFIRGRPCGHQDLVSPPIWRGVARRLAQWHAGLPSSGAASVEDVSVTKIADVQDDEITVIQPRRAGPSMWAVLQKWVLALPVTTPEQRARRLSLQAELQWALDLLDDGKGIGEDGLVFSHCDLLCANVIVLPSENGVTTPEDGIAPVNFIDYEYAVPAPAAFDISNHLAEWGGYDCDYNMMPTKSVRRQFLTDYTKSYCEQRGLDASSEAEIVDRLYEDVDRFRGIPGLYWGVWALIQAQISQIDFDYASYAETRLGEYYAWKREVDGSRKQAGEEMPLRESRWASEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P036</accession>
    <name>A0A0G4P036_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome P450 monooxygenase poxM</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Oxaleimides biosynthesis cluster protein M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PCAMFM013_S003g000420</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P036"/>
    <dbReference type="STRING" id="1429867.A0A0G4P036"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902181">
        <property type="term" value="P:verruculogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF112">
        <property type="entry name" value="L-ORNITHINE-N5-MONOOXYGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CRL19629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="530" mass="59699" checksum="5775443974251B1F" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P077</accession>
    <name>A0A0G4P077_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Winged helix-turn-helix transcription repressor DNA-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S003g000465</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P077"/>
    <dbReference type="STRING" id="1429867.A0A0G4P077"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07323">
        <property type="entry name" value="LAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF132">
        <property type="entry name" value="LA-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="4">
        <location>
            <begin position="571"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="510"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="664"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="218"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="324"/>
            <end position="337"/>
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                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P0V7"/>
    <dbReference type="STRING" id="1429867.A0A0G4P0V7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019191">
        <property type="entry name" value="Essential_protein_Yae1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052436">
        <property type="entry name" value="LTO1_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532">
        <property type="entry name" value="GEO13458P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532:SF1">
        <property type="entry name" value="ORAL CANCER OVEREXPRESSED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09811">
        <property type="entry name" value="Yae1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Essential protein Yae1 N-terminal" evidence="3">
        <location>
            <begin position="20"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL19913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="185" mass="20117" checksum="DED72BFF83AC399B" modified="2015-09-16" version="1">MEHNILDSLLDLEEQFYNEGYELGTADGAATGYTEGSVFAVEKGFEKFVEMGRLYGKALVWAQRLDIKSSEGAASQVDSTTDTLSLDPSICKDMPSLPPHSTRLARNLQTLLELVDPATLDMSNTEEAVNDVDERLKGAATKAKLIQRAMGEREDSTTQAEPKDMTTSGDGSGSIEDISALNIRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0X8</accession>
    <name>A0A0G4P0X8_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dynamin GTPase</fullName>
            <ecNumber evidence="2">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S003g000763</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="2"/>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P0X8"/>
    <dbReference type="STRING" id="1429867.A0A0G4P0X8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1240:FF:000002">
        <property type="entry name" value="Dynamin-1-like protein isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1240:FF:000022">
        <property type="entry name" value="Dynamin-like GTPase Dnm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000383">
        <property type="entry name" value="Dynamin-like gtpase dnm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF235">
        <property type="entry name" value="DYNAMIN-RELATED PROTEIN DNM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="15" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="14">
        <location>
            <begin position="27"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="13">
        <location>
            <begin position="709"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="543"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CRL19971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="796" mass="88313" checksum="1CB47147B0556637" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P1V1</accession>
    <name>A0A0G4P1V1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="2">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S004g000232</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 2">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="2"/>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P1V1"/>
    <dbReference type="STRING" id="1429867.A0A0G4P1V1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08598">
        <property type="entry name" value="PI-PLC1c_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2_dom"/>
    </dbReference>
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        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
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        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF82">
        <property type="entry name" value="PHOSPHOINOSITIDE PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="4">
        <location>
            <begin position="361"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="149"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="326"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="524"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="526"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL20292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="635" mass="70879" checksum="7FFDEB7772EDF72C" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P294</accession>
    <name>A0A0G4P294_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S004g000387</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P294"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF8">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="4"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL20446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="509" mass="56903" checksum="C7BED23F05063416" modified="2015-09-16" version="1">MHAACWTCRSRTIRCDQTSIPCAKCEKAGLECFEQRPLRWVKGIAIRGKMRGRILGEGLKPSGEHLPAQPERKEILHSRAKSSATNITPSFALQDPCIHSLDRSSRFYLDYYNIRITKLFILYDSESNPFRSLLTYAMDNSTLRKCIIAVSARHFANTGQSFNQTDNTLSPLFVNANLDALHFKRQTINALLLSLSNPVPSQKDAIMATILLLIFLDLLESGIEGWKYHLHGAEGLINLSRSLSEPGASEYVNSKPGETIQETRRFVTRQLSLVSTFGGALSGSKSSPGFGTNPDESRNQESIIRSFLGCPVFLLGAIRYFSNQRHVIETLNMHDDLSIQKHVRDTLTMLELTAKFDCLEWASKSVQSSVSSAGEIQKLSLLSEAYRTAAVLYGKRVLRAFKTSTETVASDSEDLILRLLGVIGSLKCDPALFKCLLWPSFITGLECQTHGEQQAVMGFLKMLWDLTFCLNVINASKILRDHWKRKDFDGNLASGKSDLNVIEQGWLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2X7</accession>
    <name>A0A0G4P2X7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S004g000605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P2X7"/>
    <dbReference type="STRING" id="1429867.A0A0G4P2X7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43383:SF2">
        <property type="entry name" value="AMIDOHYDROLASE 2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43383">
        <property type="entry name" value="NODULIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="252"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL20664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="411" mass="45780" checksum="B6D7C637230680BB" modified="2015-09-16" version="1">MDNLSPLRDLIQSHPLIDHHAHNLLNRESATDCDNYPIEAITSSADGRALENARTTLPSLRAITQLSELYGRACENWNDIQSAHDQSVREDYDDLIRKSLSGTHALLLDNYLRDDEDIEPLTGHDSFTVSPTKRIVQVEALAESTILQVSNARKNGESVWNNFRQLFQDALGEALDDANIVAFKSEISCRTGLDVDPYSSDDTTLGGSLIRILDSGTTRSGFEVNDKQICDWIVQQTLKAISFKKKAGVAKPLLFHTGLGDDRINLLRANPACLQPLIAQYASADIVLLHAGYPYTREAGYLASAYPNVYLDLGKVFPMVSREAQTKVLRESLEIAPTNRLLWSTGGQFHPEAFWLANRQFRQALETVLVDYVQQGDFTAAQAMKIAADVLFYNSNRLYSLNLTPSYTPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3C5</accession>
    <name>A0A0G4P3C5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WSTF/Acf1/Cbp146</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S004g000759</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P3C5"/>
    <dbReference type="STRING" id="1429867.A0A0G4P3C5"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="C:chromosome, telomeric region"/>
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        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="WSTF_Acf1_Cbp146"/>
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        <property type="entry name" value="ISWI CHROMATIN-REMODELING COMPLEX SUBUNIT YPL216W-RELATED"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WHIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WAC"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WAC" evidence="7">
        <location>
            <begin position="53"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="DDT" evidence="6">
        <location>
            <begin position="414"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="481"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="683"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="988"/>
            <end position="1032"/>
        </location>
    </feature>
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        <location>
            <begin position="489"/>
            <end position="512"/>
        </location>
    </feature>
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        <location>
            <begin position="683"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="714"/>
            <end position="726"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50827"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL20817.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1032" mass="119223" checksum="75AA7AB55065455B" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P409</accession>
    <name>A0A0G4P409_PENC3</name>
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        </submittedName>
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        <name evidence="7" type="ORF">PCAMFM013_S005g000245</name>
    </gene>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CRL21081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="ASPARTYL PROTEINASE"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0064">Aspartyl protease</keyword>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="6">
        <location>
            <begin position="90"/>
            <end position="418"/>
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        <location>
            <position position="108"/>
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        <location>
            <position position="309"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL21081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="434" mass="46819" checksum="7FF3FDEC391233C0" modified="2015-09-16" version="1">MATRISLIANPHYQKSGTKSYLYAMRKYRFTPTKGGPYFLGTTMVQTGRQFTDKPIGGRARLQQVLQKKDAVSDEVGQVGAHDIQNDSMYLAEVGIGTPVQTLSLDFDTGSADLWVWSTELPSKTLSDNKNHTVFDPTKSSSFKEKDGSTWQIKYGDGSSASGTVGNDNVNIGGLVIKDQAVEIADILSDQFAQGAGDGLLGLAFGNINTVKPEAVSTPVENMISQSDIPKSAELFTAKLGSWRDSDEPDKGESFYTFGYIDQDTVKAAEAEISYTPVDNSQGFWLFDSASATVNGKSISRAGNKAIADTGTTLALVDDETCQAIYDAIPGAEYDDDSQGWIFPSNTSADKLPVISFAVGDKQFVVQKEDLGFAEAKSGYVYGGIQSRGTMTMDILGDTFLKAIYAVFDVGNLRFGAVQRKELHQNLSVPSESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P419</accession>
    <name>A0A0G4P419_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CbxX/CfqX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S005g000255</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CbxX/CfxQ family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="EEXXEc_NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001660">
        <property type="entry name" value="NF-X1 finger and helicase protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Type VII secretion ATPase EccA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000160">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.55"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041627">
        <property type="entry name" value="AAA_lid_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000641">
        <property type="entry name" value="CbxX/CfxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050773">
        <property type="entry name" value="CbxX/CfxQ_RuBisCO_ESX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43392">
        <property type="entry name" value="AAA-TYPE ATPASE FAMILY PROTEIN / ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43392:SF2">
        <property type="entry name" value="AAA-TYPE ATPASE FAMILY PROTEIN _ ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17866">
        <property type="entry name" value="AAA_lid_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00819">
        <property type="entry name" value="CBXCFQXSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="480"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="1333"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="1611"/>
            <end position="1755"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="1892"/>
            <end position="2029"/>
        </location>
    </feature>
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        <source>
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        <source>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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    </dbReference>
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    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Dupont J."/>
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                <person name="Abraham A.L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="UPF0012"/>
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        <location>
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        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="6">
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    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50263"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL21291.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="475" mass="51734" checksum="110478C8FC32FCBA" modified="2015-09-16" version="1">MATFLKKPLKLALVQLASGADKAVNLSHARSKVLEAAKAGAGLIVLPECFNSPYGTNFFPKYAETLLPSPPTAEQSPSFHALSAIAVEANAYLIGGSIPELEPSTKKYYNTSLVFSPTGALIGTHRKTHLFDIDIPGKIQFKESDVLSPGNQLTVIDLPEYGKVALAICYDIRFPEAAMIAARQGAFLLVYPAAFNTTTGPLHWSLLARARAVDNQSYVALCSPARDLDAAYQAYGHSLVADPSAKILSEAEEKETIIYADLDNDSVANIRSGIPISTQRRFDLYPDVSAGQKSLLPEASISTPKISLAVTLPHSAQSDPTQASETTLNFTRKSSANSPSDNRSLPPTVDHPFKMSNVKTGNKRSAIADVVSREYTINLHKRCHGVSFKKRAPKAIKEIRAFAEQAMGTKDVRVDPQLNKKVWEAGIKGVPFRLRVRISRKRNDEENAKERLYSHVQAVNVKDPKGLHTTTVDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P4Q8</accession>
    <name>A0A0G4P4Q8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S005g000453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P4Q8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL21289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="151" mass="17030" checksum="ABD27C477B5A47D7" modified="2015-09-16" version="1">MQWVHGEEVALHQQTVLAIEQAISQQARVPSSNSHGILSFDIGRWSGTKQDLARRDFLTHCPSPFLSTSSSSTGSTSGPQPVKTGGRRLKVGEASRTFTEFMSDLTYLSPRAMPEPVGAFYHPTTVTDDEELRRWLEKRRRQMAEMKHKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P550</accession>
    <name>A0A0G4P550_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hydantoinase/oxoprolinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S005g000605</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P550"/>
    <dbReference type="STRING" id="1429867.A0A0G4P550"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049517">
        <property type="entry name" value="ACX-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19278">
        <property type="entry name" value="Hydant_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="4">
        <location>
            <begin position="9"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="2">
        <location>
            <begin position="234"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Acetophenone carboxylase-like C-terminal" evidence="5">
        <location>
            <begin position="549"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="3">
        <location>
            <begin position="738"/>
            <end position="1275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL21441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1276" mass="138323" checksum="926A11B3C76A6778" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5T8</accession>
    <name>A0A0G4P5T8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Chromo domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S006g000225</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P5T8"/>
    <dbReference type="STRING" id="1429867.A0A0G4P5T8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18626">
        <property type="entry name" value="CD_eEF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000076">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.990:FF:000002">
        <property type="entry name" value="mRNA export factor elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000193">
        <property type="entry name" value="Probable Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015688">
        <property type="entry name" value="eEF3_ABC2_chromodomain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF14">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="484"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="728"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1036"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1039"/>
            <end position="1065"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL21685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1117" mass="122180" checksum="1F0F6C61CB003E34" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6H3</accession>
    <name>A0A0G4P6H3_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S006g000462</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P6H3"/>
    <dbReference type="STRING" id="1429867.A0A0G4P6H3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03749">
        <property type="entry name" value="proteasome_alpha_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000016">
        <property type="entry name" value="Proteasome subunit alpha type-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035144">
        <property type="entry name" value="Proteasome_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL21922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="257" mass="28197" checksum="8E4772ABE3AEE9BA" modified="2015-09-16" version="1">MFRNNYDNDAVTFSPQGRIFQVEYAQEAVKQGSVVVGLVNKTHAVLVGLKRNAEELSSYQKKIIEIDSHMAIAIAGLASDARVLSNFMKQQSLGSKMTYGRPIPLDRIVAQIGDRAQTNTQHYGKRPYGVGLLVAGVDEAGPHLFEFQPSGLTHEMVACAIGARSQMARTYLERNLDKFEDCSRDELIQHGLSALKETLSQDKELTVDNTSVGVVGVTNGKKENFKLYEGQDTAALLEVLEQRESAGAEGETMEVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6K5</accession>
    <name>A0A0G4P6K5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S006g000495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P6K5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022085">
        <property type="entry name" value="OpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053204">
        <property type="entry name" value="Oxopyrrolidines_Biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12311">
        <property type="entry name" value="DUF3632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL21955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="349" mass="39462" checksum="CF99C18A0D857965" modified="2015-09-16" version="1">MHHLRDSLLSSLPRGTPSVTTGDHACRDRESTRQSIARGEFKEVRDVAFSNRTWLVTSRYCDIGDGVDSLERHIHSLWYMYYELGRNISSESPEHEGIVLDILRIQGMGPLTRPVRGVSGIDIARTIDGTLWNDLPFLAGDMTDFWVNNGASMSGTHRLNFATFLAKLASVRVAKDRLCQVALLIFRNLFESCQVLRTGEESDEENPNRGIKQLEVFHLLPAAISWLKIASHNLLLLSEVYWNDCPSDISKGGEEFLESELGQRSPAGFSPWRYMFWLKRLHKIQEEAKEANEKALEELATDGIEYMVNTIKERNSEVLRAYANGGDTLHQDKDLSCLKPLAGVEEPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7G0</accession>
    <name>A0A0G4P7G0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S007g000221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P7G0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL22240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="175" mass="19139" checksum="0D8F72C21CD7D7F3" modified="2015-09-16" version="1">MLPSNPSSRRIAYNAFPPVTPGEQTSPVWELGNVPIARGFYKSDQDDELSGGVLPHIQLTSSGFNTSNLGTSSPSTAAQLRPRLNFSSLKRPPELLPAFPSKRQRLQSQLAVSSALNATSEEGIPWDICELIWNMGTPLLKYHHRKIENGSSGYSCLAKKAIFKELAHREKGGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7V3</accession>
    <name>A0A0G4P7V3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S007g000366</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P7V3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL22385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="154" mass="16864" checksum="9DF86E2504101CFA" modified="2015-09-16" version="1">MCWSLPNRSRTGAAIQFESEETAAIIAVTQGFLAALSSKSRADFEKHCVRAGGMTLSPPSPTSLRFCTIGSFVEHVAGLKDDIDERIWDPEVKVHETGSLNLAAVWAPFRAKINGVVDHVGVELFVLHKLNGEWKVTGLADSCRLPTEEEMLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P8T3</accession>
    <name>A0A0G4P8T3_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">allantoicase</fullName>
            <ecNumber evidence="3">3.5.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S008g000144</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Utilization of purines as secondary nitrogen sources, when primary sources are limiting.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>allantoate + H2O = (S)-ureidoglycolate + urea</text>
            <dbReference type="Rhea" id="RHEA:11016"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
            <dbReference type="ChEBI" id="CHEBI:57296"/>
            <dbReference type="EC" id="3.5.3.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Nitrogen metabolism; (S)-allantoin degradation; (S)-ureidoglycolate from allantoate (aminidohydrolase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the allantoicase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.4" evidence="3"/>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P8T3"/>
    <dbReference type="STRING" id="1429867.A0A0G4P8T3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004037">
        <property type="term" value="F:allantoicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000078">
        <property type="entry name" value="DAL2p Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000059">
        <property type="entry name" value="Probable allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00813">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005164">
        <property type="entry name" value="Allantoicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015908">
        <property type="entry name" value="Allantoicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02961">
        <property type="entry name" value="allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045">
        <property type="entry name" value="ALLANTOICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045:SF3">
        <property type="entry name" value="INACTIVE ALLANTOICASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03561">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016516">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Allantoicase" evidence="8">
        <location>
            <begin position="25"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Allantoicase" evidence="8">
        <location>
            <begin position="206"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL22715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="356" mass="38016" checksum="60D00570C1F6463A" modified="2015-09-16" version="1">MQVAATDIDQVFAHTTNLASCNLNSKILACSNDYFASADNLLTPTPSISRPGVFVHTGAWYDGWETRRHNPDPYDWAVIKLGVAAAYIHGVEVDTAHFIGNYGEKAELQATHAPEGSGVTDAQIADPSFAGWKTLLPASPCGPSQRHGWKFDAEISQTPYTHFRLLMYPDGGFARLRLYGHAIPPPAPAVQAASAPVEELSSALNGGVALAASDEHFTPSSNILLPGRGKDMGDGWETARSRAAGHVDWAIVKLGLPGSVSKVVVDTKDFRGNFPRAVRVHGLVAGAGGDGVPSADDANWVEIVKGDKRCQADTEHVFGPDDLTAGGEDTRVFSHVKLTLVPDGGVKRFRIFGRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P961</accession>
    <name>A0A0G4P961_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S008g000248</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P961"/>
    <dbReference type="STRING" id="1429867.A0A0G4P961"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="79"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL22819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="278" mass="31282" checksum="E042DD21830697C0" modified="2015-09-16" version="1">MAQPSKADATHIPASSPKTEELLDSMDGHIHGPIDGCIPMGRESGVSERAVGESLTGIHLQPPLRRSKHFFGGSQVCLQKSSTELKADGLVSLYGLAQEVFATQPMRLFLHGLYIRGSLIERWIFDRSGMYCCETINTQDELPRFFSLVLKYRLLPHDDLGESDIVKNDDTGRFIDIADIATSAVGQLYLEDKPIALAKEAFGEGTTCYRAKKLESDRWNFVVKFKWRLATDRPEEELLKLANEKNVWGIVSLDYHKDMSRTAKLRQWALPKIHDSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P9H9</accession>
    <name>A0A0G4P9H9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome b5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S008g000400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P9H9"/>
    <dbReference type="STRING" id="1429867.A0A0G4P9H9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF72">
        <property type="entry name" value="NEUDESIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="8">
        <location>
            <begin position="43"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL22971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="155" mass="17354" checksum="54DB6C08F253F141" modified="2015-09-16" version="1">MSIASPINLILVSLFGVLVYWHFRPKAPITLPRAPPPTVFKTYTPKTLIEFNGEEGRPVYLSVRGRVFDVTPGRNFYGPGGPYENFAGRDASRGLAFQSFDEEMLTKDLSAPLDDLKDLDAEQLENLQSWEDRFLEKYLVVGKLVAEGDSEAPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P9V0</accession>
    <name>A0A0G4P9V0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S009g000027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P9V0"/>
    <dbReference type="STRING" id="1429867.A0A0G4P9V0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL23087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="128" mass="14839" checksum="260732AADC9F1EB9" modified="2015-09-16" version="1">MEGNRYEFLAIQSWVEQFWTNSDDEFGIDPEDESSSFALSFDLVMGVATAFRRLVTSFDNFMKAHRRSHSLTVRLGEEKGRRLNSLTYSARGKTFFIKYKDVTIEETRSNPMVLQKSKIDILLNLSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P9W9</accession>
    <name>A0A0G4P9W9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S009g000014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P9W9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056444">
        <property type="entry name" value="Zn_ribbon_GRF_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23549">
        <property type="entry name" value="Zn_ribbon_GRF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRF-like zinc ribbon" evidence="1">
        <location>
            <begin position="12"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL23074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="118" mass="12852" checksum="21616AA9D75E1266" modified="2015-09-16" version="1">MTIQLERSSHGWKCEQCGLPGVRLSTSSGSNDAGSRAYYKCVPCNRSLGPCPCTTPGARTTSTCPCNDSEAESLGEEQVPRRLSNADFVSEEDWEANCSPGFMVSRFKAQGKELLLWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P9Z1</accession>
    <name>A0A0G4P9Z1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="3 6">2.1.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S009g000034</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = 2-dehydropantoate + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the PanB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="3 6"/>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P9Z1"/>
    <dbReference type="STRING" id="1429867.A0A0G4P9Z1"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000003">
        <property type="entry name" value="3-methyl-2-oxobutanoate hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001452">
        <property type="entry name" value="PRK00311.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881:SF0">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL23094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="360" mass="38651" checksum="D2CFC2D39A929943" modified="2015-09-16" version="1">MAAPGFALRRTALASSSLLRTRVIPATATRTQATHTLLGSRCPVLSSHVPTPHSLSHTRHSSYSAPTPGENGKARKKVTIQTLQNMHKKGEPITMLTAHDFPSAHVADASGMDMVLVGDSLGMVALGLENTTEVIMEEMILHCRSVARATKAAFIIGDLPMGSYEVSAEQAIESSLRLIKEGRVHGVKLEGGQELAPTIKRITQAGVPVVGHVGLTPQRQNALGGFRVQGKTALGATKLLRDALAMQEAGAFMLVLEAMPSEVASIITQKLRIPTIGIGAGNGCSGQVLVQVDMTGNFQPGRFVPKFVKQYADVWDEAARGISLYRDEVKSRAFPSEEYTYPIAKDELAGFQKTVDEVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAK5</accession>
    <name>A0A0G4PAK5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S009g000292</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PAK5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PAK5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000088">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="488"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="85"/>
            <end position="517"/>
        </location>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL23352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="548" mass="61002" checksum="D0305303FDED51C3" modified="2015-09-16" version="1"> </sequence>
</entry>
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    <accession>A0A0G4PB11</accession>
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        </submittedName>
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
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        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
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                <person name="Debuchy R."/>
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                <person name="Silar P."/>
                <person name="Lacoste S."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 7" id="KW-0863">Zinc-finger</keyword>
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        <location>
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            <end position="464"/>
        </location>
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        </location>
    </feature>
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        </location>
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        </source>
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            <dbReference type="PROSITE" id="PS51635"/>
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        <source>
            <dbReference type="EMBL" id="CRL23501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PB74</accession>
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        <submittedName>
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    </gene>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.</text>
    </comment>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Deaminated glutathione amidase"/>
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    </dbReference>
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        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DEAMINATED GLUTATHIONE AMIDASE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="domain" description="CN hydrolase" evidence="5">
        <location>
            <begin position="6"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL23578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="278" mass="30876" checksum="7228FA6C5FF6286B" modified="2015-09-16" version="1">MPFDCYNKAVGQLCSTSNITSNLAQCKVLVRKAAAAGAKVLFLPEASDYIASSAEQSYSLAQSEERTSFVSSLQRDAEEQNIHISVGIHEVASETRLKNLLIWIDDKGAITQTYQKVHLFDVDIKDGPVLKESASVQPGQQIPRPFDTPIGRVGLSICFDLRFPEISLALRRQNAEIITYPSAFTVPTGKAHWEPLLRARAIETQSYVIAAAQAGPHNEKRRSYGHSIIINPWGEVVAKLGDEHEEPQIATADIDLDLVAKIRREMPLLRRNDLYPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBE0</accession>
    <name>A0A0G4PBE0_PENC3</name>
    <protein>
        <submittedName>
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    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S010g000075</name>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
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                <person name="Lacoste S."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
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        </subcellularLocation>
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        <property type="project" value="UniProtKB-KW"/>
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            <end position="38"/>
        </location>
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        <location>
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        </location>
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    <sequence length="329" mass="37910" checksum="6B1F038128F607BF" modified="2015-09-16" version="1">MAPGSGRDFNCSWEHCGKSFNRKSDLCRHYRIHTNERPYHCTVKDCNKSFIQRSALTVHSRTHTGEKPHVCDHEGCQKAFSDSSSLARHRRIHTGKRPYICHEPTCERSFCRKTTLTKHQHRSHPPGSMTRPSSEDATSEHSYHQTPVSVTVPSEQYMLAQQPYYAQSATPSHEFYSPQSVPMGSVPVHEAAPPIVSQNVPGTSPVNMPLAQQPHPQHHAHAHQIPQQQQQQQQQQQQQQQQQQQQQQQHQQQQQQHQQYLQMMQQRYDTSPRTNYLPEQYQHPSFQGHQLPPEQPMMVSYHPNYAYKPPGSRLLNQAEGTDWGFLGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBH4</accession>
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        <submittedName>
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        </submittedName>
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        <name evidence="2" type="ORF">PCAMFM013_S010g000110</name>
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        </lineage>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
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                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL23672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="622" mass="70890" checksum="208702408BDD0120" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBS3</accession>
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    <protein>
        <submittedName>
            <fullName evidence="8">RTA1 like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S010g000215</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793143">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PBS3"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF15">
        <property type="entry name" value="LIPID TRANSPORTER ATNI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195550" evidence="7">
        <location>
            <begin position="21"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="379"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL23777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="414" mass="46067" checksum="4B6E1041BBC3352F" modified="2015-09-16" version="1">MRFPVSGLFFVVMSAIVARASPVQTAVPQPGVLPRDTSPTTTATNSQTTTATTTTATEFELTLSLDLPTDTCTPTIKPDKYGWVPASECDALYLYYPSFGAAIAAAVIFGILFMAHFVQATMYKAGFAWVILMGVSWETVAYGVRAFSTHNQQDDTVVTVAQMFVLLAPLWVNAFDYMVLARMIHFFVPERRIGMFKPSLLAKIFVLLDFASFVVQMIGGLMANGTGEQQMNGIHIYMGGIGIQEFFIICFLVLAVQFQRIMLQLEKAGQLPVEKHNWRRLLYALYASLVAITVRIIYRLVEFSSGYGESNPIPYHEWYMYVFDGIPMAVAILIWNFAPPGAVLQGPDAKMPSSGIGRWLCCYGCACCCRSCRKGAKGKKNMQRLPDNDTYGDDVPLHSREPSPYRDSQYTAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBS9</accession>
    <name>A0A0G4PBS9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">asparaginase</fullName>
            <ecNumber evidence="2">3.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S010g000220</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-asparagine + H2O = L-aspartate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21016"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="EC" id="3.5.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparaginase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.1" evidence="2"/>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PBS9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PBS9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006530">
        <property type="term" value="P:L-asparagine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08964">
        <property type="entry name" value="L-asparaginase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="entry name" value="L-asparaginase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004550">
        <property type="entry name" value="AsnASE_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707:SF28">
        <property type="entry name" value="60 KDA LYSOPHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500176">
        <property type="entry name" value="L_ASNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="L-asparaginase N-terminal" evidence="6">
        <location>
            <begin position="35"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase/glutaminase C-terminal" evidence="7">
        <location>
            <begin position="229"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="active site" description="O-isoaspartyl threonine intermediate" evidence="5">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604550-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL23782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="356" mass="37740" checksum="357BEFF4582D86CA" modified="2015-09-16" version="1">MFLCKISNSDPRLYNTGDGTILSGSTHGRLDTIAYGGGSGGLTPETLIDSVHEVLDIAQFAVRNISGTGSANADSDRFLNISMDAQQRLCTPDSDVVGAVMIHGTNTLAETAFGVDLTLNCSKPFVATGSMRPNSAMSPDGPRNFYDAVRTAIHPESRDRGALIAFNDHLVSAFYGTKTNGNTVSTFLATDQGYIAQVIAGQPYFFYGASLPKARHYFNPFNLTHPLPKVVVLYGHQGFDANLLYAAAADGAKGIVIMGVGPGGLSTAATEAAEDLHGKGVVTVASLRPFFGAVVPSPEPGNIISSGFLHGEQSRIQLQLALASGFEFTEIRRIFEGEIRKAVFNSATTYYNATSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBZ5</accession>
    <name>A0A0G4PBZ5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="13">MAP Kinase Interacting Kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S010g000278</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PBZ5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PBZ5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14212">
        <property type="entry name" value="PKc_YAK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000087">
        <property type="entry name" value="Dual specificity tyrosine-phosphorylation-regulated kinase 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000380">
        <property type="entry name" value="Serine/threonine-protein kinase ppk15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF17">
        <property type="entry name" value="HOMEODOMAIN INTERACTING PROTEIN KINASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="344"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="692"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="49"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="703"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="755"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="787"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="799"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL23840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="886" mass="98688" checksum="7EEC89E8D395461F" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBZ7</accession>
    <name>A0A0G4PBZ7_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S010g000264</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PBZ7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PBZ7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL23826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="125" mass="13498" checksum="36CD1F12AA75D1C3" modified="2015-09-16" version="1">MAAVIKAINAKIRSNSVLDYVCSTHFWGPVSNFGIPIAAVMDTQKDAEIISGPMTGALVVYAATFMRYSLAITPKNYLLFACHLTNFGAQTTQGFRYLNYWKWGGREKQLAEQAAKGGAAAEAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDE2</accession>
    <name>A0A0G4PDE2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MARVEL-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S011g000325</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PDE2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42083">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42083:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="26"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="201"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL24331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="240" mass="26959" checksum="4F917011D776B4B4" modified="2015-09-16" version="1">MAKSTPRTIDQYWHRSGLCGVISRATLRILQFVFAVTVAGLYGVDLAHSTKSNNHAHSEWIYAEFVAALSALTCIVHCFFTVTQVGWSAWDGVLFVLWLAQVGVFGNAYTSHVNPEYETATLSIPRMRAAVWINLVNMMLWFATMVLGISWCIRTRKVKRGTDQFNVATEGLIGPDGVKRICDEESGRWIGEEKDVKECTDKTDDDKCLQKQEQEQEHTKSSPASVDKKENLGQEKEGHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDE4</accession>
    <name>A0A0G4PDE4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Interferon-induced Mx protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S011g000308</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PDE4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PDE4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF215">
        <property type="entry name" value="DYNAMIN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="5">
        <location>
            <begin position="34"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="4">
        <location>
            <begin position="589"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="562"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="562"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL24314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="676" mass="76294" checksum="2D57178948A00307" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PE02</accession>
    <name>A0A0G4PE02_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S012g000180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PE02"/>
    <dbReference type="STRING" id="1429867.A0A0G4PE02"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL24570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="315" mass="36596" checksum="4B2AA26F7ACCA828" modified="2015-09-16" version="1">MNIETHPAPHEFLNALYYRIHGFEPDFPSPSDLQMLGIQAFQVATANDETIKFDPFFFLPHPERLLQKYPLDDSSATSLSKPRTLRDPTPTLENLLKDGARDPSSDPEAKLEDAKSRLRWVLRDRDYYKNKWYTHADQVHSHICQEVFARRKGPTGTFYPCDLVGQSLWSPKWRKGEPYTLCLEPKEWRVMEQYRYSGYRPPKPHGVISCLAHVCTTDINQGLATHELRAIVNIMVIRTLHRPFRDCQIHPILVLSYLGYRKARIIQAVYDGQGLTLQYSQLWTFDNEETAPVEMFVRYRLSQPIGLEVSTVCVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PES9</accession>
    <name>A0A0G4PES9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S013g000057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL24815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PES9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PES9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009686">
        <property type="entry name" value="Senescence/spartin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045036">
        <property type="entry name" value="Spartin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21068">
        <property type="entry name" value="SPARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21068:SF43">
        <property type="entry name" value="SPARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06911">
        <property type="entry name" value="Senescence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Senescence" evidence="2">
        <location>
            <begin position="249"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL24815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="510" mass="53564" checksum="46809B483B3821FF" modified="2015-09-16" version="1">MASAANDPRLLYSVNNIRAFHIQDGEEQDLTPSGPQTLSLLMVPTNTATAGPGTEWPEDSPEEDFYLHLYLPPELDIAIPATTQIFHQPPDSYLIPRWDMGPDAGAFIRIQFPSIGTGPSNVSQDDIDTFESILAQCTAFLERAPQPKAQDYTSYNPANYAPGEGYVGTPDAKKADAHGRIVLVDEENGSVVGELGDGYNVVEDADVKPGSKRPVGIELPAEGEGNQVSVTNVSEEYLAMARHPAYKNSTLVQSSATASRLIVTGSTYLASAIASGAETFQKKTQPNVKPVKFSDATHARIRKVGTFSNGAADISARTVGQVGRVAQNIGASLARKQESGRNKGIDRRNPPPEYKPGVLNKSMIAFSTLADGIEQSARNMLFSGAGAASSMIEHRYGNEAGSVATNLTGGIKNVGLVYIDATGVSRRALLKSVAKGMVVGKMRDGQQVVVGGGDGGQVPANVVESASGPSGLSARDPVVRRASPNPTPPPAYGASGTTSLNASSLSGGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PF87</accession>
    <name>A0A0G4PF87_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Isoleucine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCAMFM013_S013g000231</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="3"/>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL24988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PF87"/>
    <dbReference type="STRING" id="1429867.A0A0G4PF87"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00818">
        <property type="entry name" value="IleRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000044">
        <property type="entry name" value="Isoleucine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000004">
        <property type="entry name" value="Isoleucyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000023">
        <property type="entry name" value="Isoleucyl-tRNA synthetase,cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000050">
        <property type="entry name" value="Isoleucyl-tRNA synthetase,cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02003">
        <property type="entry name" value="Ile_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19302">
        <property type="entry name" value="DUF5915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13 16" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="14">
        <location>
            <begin position="11"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="15">
        <location>
            <begin position="689"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CRL24988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1075" mass="123394" checksum="02A9AC694E70B018" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PG90</accession>
    <name>A0A0G4PG90_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dipeptidyl-peptidase V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S014g000224</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S9C family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PG90"/>
    <dbReference type="STRING" id="1429867.A0A0G4PG90"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000028">
        <property type="entry name" value="S9 family peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="WD40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776:SF11">
        <property type="entry name" value="DIPEPTIDYL-PEPTIDASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776">
        <property type="entry name" value="SERINE PEPTIDASE S9 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="12">
        <location>
            <begin position="538"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL25328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="770" mass="84999" checksum="00EDA13941847112" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGD0</accession>
    <name>A0A0G4PGD0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S014g000243</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PGD0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PGD0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.270">
        <property type="entry name" value="Vacuolar protein sorting-associated protein vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044538">
        <property type="entry name" value="Vta1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039431">
        <property type="entry name" value="Vta1/CALS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023175">
        <property type="entry name" value="Vta1/CALS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041212">
        <property type="entry name" value="Vta1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04652">
        <property type="entry name" value="Vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18097">
        <property type="entry name" value="Vta1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vta1/callose synthase N-terminal" evidence="10">
        <location>
            <begin position="14"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Vta1 C-terminal" evidence="11">
        <location>
            <begin position="354"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="185"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="314"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL25347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="391" mass="41895" checksum="047A36C3A4D5DD1C" modified="2015-09-16" version="1">MASNIPAGLRSADIGRFAIRAAQIEKAKPVVAYWCNFHIVNQIIERGLHNADDEIKLYTTNLVDKLEQFKVENPENDTVTDTVAASAYVEQFGLEVFSRAEAAMNANKVTKQTGDTFLAAATFLELCSIWGPLDPELAGRIKFAKFHAVRIVKALKAGEDPNATNPAPKQEEELADDPDVQAFDESVAEQASRPRQASIEEIPDESDRLGRELARKSTLDESLHPSRTSSTPRGPPEIPSVPRNAPGSPLQPMDVDDANTGGLELPSTPATIGGSSSVPRLPDTPTAFQSFPPPSEEPSVSTPDPASFYDTPGPSAPIPPPVAPTFIPPPAANIPVAPAPYVPPQPSHGLDDNTVQLAQKHARWAVSALNFDDVDTAIKELRSSLKLLGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGG3</accession>
    <name>A0A0G4PGG3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S015g000010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL25424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="70" mass="8289" checksum="00BCB083C74CED07" modified="2015-09-16" version="1">MEELHTRMKFIERSSFDQRARDETVRKELDEICTRLMIVETEIQKVVKRGHNKGAEGQKTSRSLRRGNND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PHX9</accession>
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        <submittedName>
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    </protein>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
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                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
                <person name="Silar P."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        </subcellularLocation>
    </comment>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF39">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="5"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL26020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="465" mass="51939" checksum="FB571864CB5B61D4" modified="2015-09-16" version="1">MASRSCGTCRDRRIRCDRTVPACSQCSQSNRTCKGYGLRLSWPKVDDKRRAMVARSSLQQRSARPRFSNAHLVNISTWNIEMHRYLFGLVSSVQSTASCSLTTFGHDPTNVGNMLIRMALVNNAPSTTAVLRSLLALSSLHRSGLQSQAAELKIAALNALSVASNREISAMETIQHVAAGMLLCSFEIHQASCTSGQWRSYIIGVKSVIKASSLDAFKRDSDFNTLLDWVYYHDVLSRFSLTHWHPPAIDRPPVDLDDPIDTLSLPVNTDPCMEITHSTQSPFTKILRSLTEVCNLVATNMTHIPASEEADNFKSYLKILAWKVRSISFSDTIIDENPSLAALVELFQLATLIYLNRAFGNILESAAETQQRVERAFSIFSELSSCERQYPLFILGCEARTDAERYIILDLISRTEKGDSSRSLFITKKLIQAIWVQDDLSQGEIDYTEKLSAIMSCCTILPTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PI18</accession>
    <name>A0A0G4PI18_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Condensin complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S017g000015</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the CND2 (condensin subunit 2) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793150">
        <property type="protein sequence ID" value="CRL26032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PI18"/>
    <dbReference type="STRING" id="1429867.A0A0G4PI18"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022816">
        <property type="entry name" value="Condensin_barren_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108:SF9">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05786">
        <property type="entry name" value="Cnd2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017126">
        <property type="entry name" value="Condensin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="8 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="181"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="277"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="654"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="751"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR017126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL26032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="866" mass="94377" checksum="65D4B0E837FFA023" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PIB3</accession>
    <name>A0A0G4PIB3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S017g000110</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793150">
        <property type="protein sequence ID" value="CRL26127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PIB3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF38">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="35"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL26127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="453" mass="49764" checksum="5A1F839129A929EB" modified="2015-09-16" version="1">MSISVEHSKSQDTFRSMIVDLDAEKKLVRKIDLYLMPSIFILYLFSYMDRSNIGLAKIAGMEEDLHLTSHQYYTAVIVWIIGYTISAVPSNMILSRTRPSVFLPIITFAWGSVAALIGAVRNQGQLIALRFLLGVFEAGFSPAVIFLISTWYRKNEQSKRFLIFLTAGILSGAFGGVISGAITSTLDGAHGIRGWRWLFIVEGVATAGVSLIVHWTLLDYPHSSRGLSPEERKLAQQRLIEDGIADQGDSKTPNTSIFAPLLKALSNWRTWVLIPGYMTLVGAGAISYFYPTLVNDMGYTSTTAQYMTAPLYIASLAAAIPICWFADRKPHTRGQLLVGNMIVGMVFFALTAGIRNYTARYVFLCFINMTLWTGNALALSFATTALASVTRDVRAIMLAWMTSVAALAQLYGTALFPVEDSPGYVVGFSVFAGTFAVGAVCYGLADILFKRYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PIJ5</accession>
    <name>A0A0G4PIJ5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Vacuolar protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S017g000152</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 10">Functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Vacuole membrane</location>
            <topology evidence="1 10">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the beta-catenin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793150">
        <property type="protein sequence ID" value="CRL26169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PIJ5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PIJ5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071562">
        <property type="term" value="P:nucleus-vacuole junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000011">
        <property type="term" value="P:vacuole inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000243">
        <property type="entry name" value="Putative Vacuolar protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000095">
        <property type="entry name" value="Vacuolar protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045156">
        <property type="entry name" value="Vac8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47249">
        <property type="entry name" value="VACUOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47249:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0926">Vacuole</keyword>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="106"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="147"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="188"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="229"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="272"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="313"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="354"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL26169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="578" mass="62870" checksum="8AB96FCFF1356E36" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PIK3</accession>
    <name>A0A0G4PIK3_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="9">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S016g000294</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="9"/>
    <dbReference type="EMBL" id="HG793149">
        <property type="protein sequence ID" value="CRL26013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PIK3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PIK3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000014">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF111">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="11">
        <location>
            <begin position="130"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL26013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="563" mass="61812" checksum="148EB57C66CCCA3B" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PIM5</accession>
    <name>A0A0G4PIM5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-directed RNA polymerase, dimerisation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S017g000009</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793150">
        <property type="protein sequence ID" value="CRL26026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PIM5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PIM5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06926">
        <property type="entry name" value="RNAP_II_RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037685">
        <property type="entry name" value="RBP11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008193">
        <property type="entry name" value="RNA_pol_Rpb11_13-16kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF16">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01154">
        <property type="entry name" value="RNA_POL_L_13KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="6">
        <location>
            <begin position="67"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL26026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="163" mass="18146" checksum="58779D7663D213D7" modified="2015-09-16" version="1">MPQSPGIITATAAIARERAGRRNQGPHSRHPRPMLPDDAPDVYEAILLAPGESKIDVEVDTRLPSAAIFTFHKEDHTLGNMLRQRLLKTAHVIFAAYRVPHPLTPEFQLRVQTDGEVTPRQAVINASEALIKDLGILSREFTKEYELRKAANAANQQQQNPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PIV9</accession>
    <name>A0A0G4PIV9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S017g000124</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG14 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793150">
        <property type="protein sequence ID" value="CRL26141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PIV9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PIV9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018791">
        <property type="entry name" value="UV_resistance/autophagy_Atg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157:SF5">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10186">
        <property type="entry name" value="ATG14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="42"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL26141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="594" mass="67119" checksum="04F52BBDF98655D8" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJ80</accession>
    <name>A0A0G4PJ80_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin-like fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S018g000082</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJ80"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJ80"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000245">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="25"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL26389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="137" mass="15077" checksum="19F19721F67A465A" modified="2015-09-16" version="1">MELKTVLILAVIYIAIRLFFKSRNSSPAATMSHGKVTEIDNQVIFKALISSGPVVVDFFATWCGPCKAVAPVVGKLSEQYENVRFLQVDVDKLQSVARELSVNAMPTFVVFKDGKEVNRVVGGDMKKLEAQIKEISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKA8</accession>
    <name>A0A0G4PKA8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sin3 associated polypeptide p18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S019g000231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKA8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PKA8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.550">
        <property type="entry name" value="ASAP complex, SAP18 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010516">
        <property type="entry name" value="SAP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042534">
        <property type="entry name" value="SAP18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082:SF0">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06487">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL26814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="246" mass="26066" checksum="5DC449E08B7AC21E" modified="2015-09-16" version="1">MAAPSRDGPKPSINRQTTAPFHLKLFYRVNNYNPLSDYSIPVQPRRGGPSTLRELSQLLTSALPSLLPDPPVGTRLCFRLIYPDARGAAMGGPDARGRYLSRDLGSAIVGPRDSTLRAEDDEDKEARPRPGPLRFQGSEADRPLQDARFIVGDYIECAILAPLEDGSVAPALNGASGPIMGPRGGGGGGMRAFRDNGYPRGPGRGGPRGGGGGGGGGPPHMPRGDWHRGERLPEGARGGRRGWAPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKZ9</accession>
    <name>A0A0G4PKZ9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HSP20-like chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S021g000022</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793154">
        <property type="protein sequence ID" value="CRL27107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKZ9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PKZ9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="40"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="87"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL27107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="200" mass="22325" checksum="D77DEC926F9A0579" modified="2015-09-16" version="1">MAFFSQSGLSPLFLFNDYEAQNQYNPRQCPKSYKCSKPQARRPSFMPAFDVRELTHAYHLDGELPGVDQSNIEIEFTDPHTLVIKGHTDRDSINDDNHNDDASSSRSASPAGWHQATVEDEDAESTSSADTAASNTASHPTENDQPHFWAKERSIGDFQRTFSFTARVDQDNVRASLKNGVLSVIVPKEATPTPKKIRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PLP9</accession>
    <name>A0A0G4PLP9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rho GTPase activation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S021g000013</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793154">
        <property type="protein sequence ID" value="CRL27098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4PLP9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13277">
        <property type="entry name" value="PH_Bem3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000452">
        <property type="entry name" value="Rho GTPase activator (Bem3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000066">
        <property type="entry name" value="Rho GTPase activator (Bem3), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF129">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 16F, ISOFORM E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="723"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="5">
        <location>
            <begin position="1023"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="280"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="709"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="771"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="841"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1223"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="414"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="715"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="774"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="841"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1242"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1273"/>
            <end position="1284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL27098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1338" mass="145634" checksum="4B935315F57D2B27" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PM28</accession>
    <name>A0A0G4PM28_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Molybdopterin synthase sulfur carrier subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Common component for nitrate reductase and xanthine dehydrogenase protein G</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Molybdenum cofactor synthesis protein 2 small subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Molybdenum cofactor synthesis protein 2A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Sulfur carrier protein MOCS2A</fullName>
            <shortName evidence="5">MOCS2A</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cnxG</name>
        <name evidence="6" type="ORF">PCAMFM013_S022g000152</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by UBA4. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of UBA4, then thiocarboxylated (-COSH) via the rhodanese domain of UBA4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MoaD family. MOCS2A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793155">
        <property type="protein sequence ID" value="CRL27472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PM28"/>
    <dbReference type="STRING" id="1429867.A0A0G4PM28"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990133">
        <property type="term" value="C:molybdopterin adenylyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990140">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030366">
        <property type="term" value="F:molybdopterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00754">
        <property type="entry name" value="Ubl_MoaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03051">
        <property type="entry name" value="MOCS2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044672">
        <property type="entry name" value="MOCS2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028887">
        <property type="entry name" value="MOCS2A_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33359">
        <property type="entry name" value="MOLYBDOPTERIN SYNTHASE SULFUR CARRIER SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33359:SF1">
        <property type="entry name" value="MOLYBDOPTERIN SYNTHASE SULFUR CARRIER SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="MoaD/ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="1-thioglycine; alternate" evidence="5">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="modified residue" description="Glycyl adenylate; alternate" evidence="5">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL27472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="86" mass="9165" checksum="7F88184011DBDCF4" modified="2015-09-16" version="1">MPETFTIHYFATASQYTSKNTESLPAPLKLSALFGELEQRYPGIAPKVLSTCGVSLNGEYVDVEEDTETTIQAGGEVAIIPPVSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMP9</accession>
    <name>A0A0G4PMP9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Reverse transcriptase, RNA-dependent DNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S023g000092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793156">
        <property type="protein sequence ID" value="CRL27634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PMP9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PMP9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL27634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="126" mass="14762" checksum="66BF0EE9BB92791D" modified="2015-09-16" version="1">MPGCPMSWLTQDQALRKPRYLQITGRQRWKARYNLNSKDTFDIGRKPKGVKILLSRWFHDVKCTKDNVVYGVRARWVVCGNHQIKKRIICHAPVVQNTWWRSLSRLLHEGHSHGGCLTQLLRVSMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMT4</accession>
    <name>A0A0G4PMT4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid transporter, transmembrane</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S022g000126</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793155">
        <property type="protein sequence ID" value="CRL27446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PMT4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PMT4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF683">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="49"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL27446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="467" mass="49542" checksum="6DF877941880BF9E" modified="2015-09-16" version="1">MDVYEPPKDEPIDETKDDLAIKPTQTTTHDVVFGEITEDGPNYRNVGFLGTVTLMMKSQIGLGILSIPSAFDALGIVPGVICLLAIGGITTWSEYVIGTFKLNHREVYGIDDAGALMFGPIGRWVLSVVFCLYYIFVSASGILGITIGLNSVSTHGICTAAFAAIAAILGFATSSVRTLGRIAWLAWVGLPCILAAVLTVSIAVGVQDRPPSAPQTQAPWSSDFKIIGNPSFVKGITAISNLTFAFSGTPGFFAIVSEMRNPRRYTPALLICQACVSSIYTVIACVIYYYCGSYVASPALGSAGGVVKQIAYGVALPGLVVTTTIVIHIPAKYIFVHLLRGSPHLNSNTPTHWLSWLGCTFGVTVIAYIIASTIPAFDALVSLIGALLGTILCFQPYGCMWLYDNWATGRDKSRAWLPMVCFSAFVIAFGCFLTVAGTYGTVVGIINSYAESGGSAAFSCADNSNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMT5</accession>
    <name>A0A0G4PMT5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S023g000127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793156">
        <property type="protein sequence ID" value="CRL27669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PMT5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PMT5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL27669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="582" mass="65406" checksum="50F75CDEF5123434" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMX9</accession>
    <name>A0A0G4PMX9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S024g000052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793157">
        <property type="protein sequence ID" value="CRL27797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PMX9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00048">
        <property type="entry name" value="DSRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL27797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="148" mass="15787" checksum="98B3F081C616F30A" modified="2015-09-16" version="1">MYYILYLTSLCRRRNWPEPIYNAYISNSGYTCTVRVNNREYRTDSICSNETLARESAAMRAYLICRNFSVNDGMYPAGHEHGGAVQGMRVAIGAGRKPAREDDVLSLGSASGSGTGSDGSQGGSWSGGSSPVRVGIEGDSRGGFGGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PN90</accession>
    <name>A0A0G4PN90_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">Small nuclear ribonucleoprotein Sm D2</fullName>
            <shortName evidence="13">Sm-D2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 13">snRNP core protein D2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S023g000104</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793156">
        <property type="protein sequence ID" value="CRL27646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PN90"/>
    <dbReference type="STRING" id="1429867.A0A0G4PN90"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01720">
        <property type="entry name" value="Sm_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000018">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027248">
        <property type="entry name" value="Sm_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12777">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 13" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13 15" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="14">
        <location>
            <begin position="38"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00058057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CRL27646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="117" mass="13245" checksum="3747AAF6C9CA0E1D" modified="2015-09-16" version="1">MSTAPEPQIQDLLNKPKSELTEYEVALVEEHELTAGPLSLLQTATRTHTQVLISCRNNRKLLARVKAFDRHCNMVLENVKEMWTEKPKGAKGKGVNKDRFISKMFLRGDSVILVLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNJ0</accession>
    <name>A0A0G4PNJ0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S025g000060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793158">
        <property type="protein sequence ID" value="CRL28002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PNJ0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF198">
        <property type="entry name" value="AZOLE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="530"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="64"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL28002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="557" mass="59462" checksum="AEEFAE827FADD075" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNT7</accession>
    <name>A0A0G4PNT7_PENC3</name>
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        <recommendedName>
            <fullName evidence="4">endo-1,3(4)-beta-glucanase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S025g000088</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;3)- or (1-&gt;4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolyzed is itself substituted at C-3.</text>
            <dbReference type="EC" id="3.2.1.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.6" evidence="4"/>
    <dbReference type="EMBL" id="HG793158">
        <property type="protein sequence ID" value="CRL28030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF42">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G02280)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="12">
        <location>
            <begin position="95"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000124"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012599"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL28030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="383" mass="42027" checksum="F801CDEC6F13CA83" modified="2015-09-16" version="1">MANRQLPYLNRYSGTNPSLPTLETKSPIATSSQPEGDRDTPAQEPWYNPQGWSLRTKLIASATAIVIILAAILIPVEIIKNQYPNYTPLNYTLADEYSGPTFFDQFTYFTDEDPTKGFVVYVNKSTARHLNLTYASESSAILRVDASTPNASSGRNSVRVESRNTYDSGLFVFDIIHTPFGCATWPALWLTDGYNWPMNGEIDVLETTNVGSHGNEISIHTTQGCHMDVKRKQTGHGIFNNCNNATDGNSGCAVIGDENSYGEAMNNRGGGVYALELRDAGIRAWFFPSGTVPADITAENPDPSSWGIALADFPSTNCDIASHFKNLSIIVNIDLCGELAGQKQYYDTLYHCPATCSGFVASSPGSFVDAYWEFKSFKVYRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PP28</accession>
    <name>A0A0G4PP28_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CCT-theta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S024g000121</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793157">
        <property type="protein sequence ID" value="CRL27866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PP28"/>
    <dbReference type="STRING" id="1429867.A0A0G4PP28"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03341">
        <property type="entry name" value="TCP1_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000008">
        <property type="entry name" value="T-complex protein 1 subunit theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012721">
        <property type="entry name" value="Chap_CCT_theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02346">
        <property type="entry name" value="chap_CCT_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="474"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="551"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="483"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL27866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="571" mass="61600" checksum="556C30341FA78EA9" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PP30</accession>
    <name>A0A0G4PP30_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GmrSD restriction endonucleases C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S025g000006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793158">
        <property type="protein sequence ID" value="CRL27948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PP30"/>
    <dbReference type="STRING" id="1429867.A0A0G4PP30"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="GmrSD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24094:SF15">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24094">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07510">
        <property type="entry name" value="GmrSD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195500" description="GmrSD restriction endonucleases C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="GmrSD restriction endonucleases C-terminal" evidence="2">
        <location>
            <begin position="106"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL27948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="207" mass="22137" checksum="3DEE4887670AAF69" modified="2015-09-16" version="1">MGISRAAWALAFAFQPFLGGALPAPSPPGIPSTSTATSELAGLTVAAQGSQDGYSRDEFPHWITISGNCNTRETILKRDGTDVVQSSSCGATSGSWFSPYDGETWTAASDVDIDHVVPLSNAWKSGASSWTKADRQAFANDLKNPQLLAVTDNVNSAKGDKGPESWRPPLASYYCTYAKMWVKVKSVYDLTITSDEKAALVEMLDTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPB5</accession>
    <name>A0A0G4PPB5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl transferase, group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S026g000089</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793159">
        <property type="protein sequence ID" value="CRL28224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03801">
        <property type="entry name" value="GT4_PimA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12526:SF510">
        <property type="entry name" value="D-INOSITOL 3-PHOSPHATE GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12526">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20706">
        <property type="entry name" value="GT4-conflict"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="3">
        <location>
            <begin position="1081"/>
            <end position="1182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL28224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1298" mass="142529" checksum="3282C15902032C8D" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPP5</accession>
    <name>A0A0G4PPP5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S026g000068</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793159">
        <property type="protein sequence ID" value="CRL28203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PPP5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="28"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="491"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="512"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL28203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="523" mass="58870" checksum="A47DED2EA7394780" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPT3</accession>
    <name>A0A0G4PPT3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Extracellular membrane protein, CFEM domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PCAMFM013_S026g000103</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG793159">
        <property type="protein sequence ID" value="CRL28238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PPT3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PPT3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF2">
        <property type="entry name" value="GPI ANCHORED CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G10580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195734" evidence="17">
        <location>
            <begin position="19"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="18">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="94"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="97"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="50"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CRL28238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="214" mass="20381" checksum="5A2A7D8308AA4B75" modified="2015-09-16" version="1">MKFSTTLIAFAAAGLASAQLPDVPACSLSCFLSALQGDGCSELLDFKCHCQKTELVSSITPCVAKACEHSDQVSVSNAVVNQCSSAGHPISIPPIETSASSSASASETSTPSSAPAETTATATPTASASESSSAVESSSSAAETESSTTGAGAGTTASGSAPAGSSGAATSTPLVTTTGSATASTSSPAFNGAGNVKGNMAGVAALAAAAAYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQ44</accession>
    <name>A0A0G4PQ44_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome b5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S026g000151</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793159">
        <property type="protein sequence ID" value="CRL28286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQ44"/>
    <dbReference type="STRING" id="1429867.A0A0G4PQ44"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF28">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="9">
        <location>
            <begin position="3"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL28286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="513" mass="57252" checksum="6478ACD1046D3A8E" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQU4</accession>
    <name>A0A0G4PQU4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S030g000057</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793163">
        <property type="protein sequence ID" value="CRL28770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQU4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PQU4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="8"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL28770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="478" mass="53597" checksum="7CBCD8644726C682" modified="2015-09-16" version="1">MRQSLRRSCAACARSKSSCDLRTPRCSRCIKRQVECAYANEPSTGPATSGWQNGASTNALDGPGTLTNYTFGSLDPFESYPQTRLPREHVQRLIYTFLHKIAFQYYPLDLNATSNPFLISWWPLALGDPALFHVSLQTACLDEELLAQKGFQTSELLMADSVALLRRKVEYMSLAVQDGTMNSVITLATIEFGKGNIKVGEMHVNGLKKLVDMRGGINAVRQTSPLTARMISWVSMLIMGHPQFETQDDFGIGDGIPPIPEWQFDSTALDDHLFDLSTIEVDYAVKNVFNRLRNIFHRVRNIPFPATQLHDLTCFVIHRLLLSAPPTTILMPSPMTESIRYGIILYMFIAQGPTYYSHAVILNTILTRFMENLEHLASTPRVYDSFDVWLAAVGMVASAGTAHHQQFMKRARDVAAALQLGNFGDTLIHIKTVLWLEKSQCEDLFRSHWGTIFNPTDQSVVSDLSMSVSPYSSNVEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRZ4</accession>
    <name>A0A0G4PRZ4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flavin-containing monooxygenase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S034g000022</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793167">
        <property type="protein sequence ID" value="CRL29224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PRZ4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PRZ4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000258">
        <property type="entry name" value="Flavin-binding monooxygenase-like protein (AFU_orthologue AFUA_6G01900)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL29224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="587" mass="65588" checksum="B9CF720D0BE80F25" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PSC9</accession>
    <name>A0A0G4PSC9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S032g000099</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793165">
        <property type="protein sequence ID" value="CRL29063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PSC9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PSC9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF155">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="35"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL29063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="359" mass="39854" checksum="E7529E305164802D" modified="2015-09-16" version="1">MAGSITDAPKTGNKGPQMMAVMWSMTTLATFLVIARLCVRQRMLRNFGFDDWLIGASMIFGILFVATATVSVTYGYGQHKMNLEPRSAELALMWNMISFIFGIISFAIPKLAVAALLHRILNPNLTQRIIVWGLVSLIAVIALVNILIYVTMCDPQQALWKSSMVLSGEAKCRDIWILIDYATFNGAFSAFVDLFLAIYPGVVLFKLQMSLRKKIALSAALGLGAIAAATAMVKCAQIKGLADQADPTFSTVPLVVWTNVEANVVVIAACIPTLQPMLELILRKLKLVSTSKGHSKPSSYAQHKVYDNQLSSRAHVSKKERTTPLRKKESQESILNDLEQYQIRRTDEVHVEYEMQRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PSK7</accession>
    <name>A0A0G4PSK7_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit beta</fullName>
            <ecNumber evidence="13">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S035g000067</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="13"/>
    <dbReference type="EMBL" id="HG793168">
        <property type="protein sequence ID" value="CRL29372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PSK7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PSK7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18110">
        <property type="entry name" value="ATP-synt_F1_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18115">
        <property type="entry name" value="ATP-synt_F1_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01133">
        <property type="entry name" value="F1-ATPase_beta_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000001">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.170:FF:000005">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000026">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050053">
        <property type="entry name" value="ATPase_alpha/beta_chains"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184">
        <property type="entry name" value="ATP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184:SF71">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039072">
        <property type="entry name" value="ATPase_subunit_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 13" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="187"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CRL29372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="519" mass="55373" checksum="12F39B5A04D51AB6" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PST4</accession>
    <name>A0A0G4PST4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hydroxyneurosporene synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S034g000021</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793167">
        <property type="protein sequence ID" value="CRL29223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PST4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PST4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057722">
        <property type="entry name" value="AsqO/PenF-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056402">
        <property type="entry name" value="DA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25581">
        <property type="entry name" value="AsqO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24137">
        <property type="entry name" value="DA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159245">
        <property type="entry name" value="AttH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195938" evidence="2">
        <location>
            <begin position="18"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Diels-Alderase N-terminal" evidence="3">
        <location>
            <begin position="81"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="AsqO/PenF-like C-terminal" evidence="4">
        <location>
            <begin position="268"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL29223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="433" mass="47347" checksum="77BB846092E1362A" modified="2015-09-16" version="1">MLPLLLIYALLAQQALAFPSQHRTHEKPLPYPLRASRDTSSGSYKIPSAVQNGTSKAQFEISTPATTLDIETLFRLDAPQIDSINGSVFDWWYFDAVSETNPDDSLVVTFFSSSAEAFPFLNANETSVLTVWLWASFANGTIFTDSVPATVATVTGADGAGTNSSGEWSSTGFSWASLIEDLSQYEIIIASEKLQVEGRLTLTSQVPHHLPCGVQAERTVLEIAPHIGWVNLIPDAVGEVDMKIHGSTLKFRGPGYHDKNWSDRPFVDSVNSWYWGHGRLGPYSIVWFSYLAIDDPTNTTHVSSYVAKDGEVLVSACDPSILTVRPIGSPGTTGGRYPPRMGDLPEGFRLEYDLGEGRGQLKVNVSVRTVVAGNGKDYMRWTGDMVGEVIESESRRPQETGGDGPKKEMRERAEQSSSSLVGVAVLEQFVMVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUB0</accession>
    <name>A0A0G4PUB0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S042g000042</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793175">
        <property type="protein sequence ID" value="CRL29983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4PUB0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NACHT" evidence="7">
        <location>
            <begin position="51"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="610"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="887"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL29983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1351" mass="150994" checksum="3B49127598ADF5F1" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUK7</accession>
    <name>A0A0G4PUK7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein family UPF0363</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S044g000029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GET4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793177">
        <property type="protein sequence ID" value="CRL30098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PUK7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PUK7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000272">
        <property type="entry name" value="DUF410 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007317">
        <property type="entry name" value="GET4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875:SF0">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04190">
        <property type="entry name" value="GET4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="318"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL30098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="344" mass="37680" checksum="48AEFCA018FB7C3C" modified="2015-09-16" version="1">MSSRIDKVIARQREKIADGAYYEAHQQLRVIAVRYIKQSNYDAAAEILAGGAKELLKAGSQQGASASGGDLAIMLVLEVYNKAEWEIAGGNDDAEGRARKKRLIELLREFPSDEPTRKRFIQEMIGWSAKFGPLERGDPDLHHAVGSVYAEDNEPYDAEKHLILGTSESAETLAKLEYEWYTSDEPHTAAIYASRAVFPYLLTGNIRSANKALLIFTSRLAAANPQLGVQDVSSASSDARVFPALPLVNFISMLLLAIQRGSADLFRQLTAHYATQIREVGIWDDALAQIGEQYFAIKIPRQGNPLMDMMSGMLFGGGQNKTGGKGASRTAKKVEAPPSSMELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVE6</accession>
    <name>A0A0G4PVE6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclin-like F-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S045g000010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793178">
        <property type="protein sequence ID" value="CRL30144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PVE6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PVE6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="28"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="424" mass="48922" checksum="DD83A36C3FBA3931" modified="2015-09-16" version="1">MIMKTLTRVKSYLTRPNKAISPSEIPRMTTLAGLPPELLLSISDFLPVVDLVCFSVCNRRFFALSQRQIKRLPPRTQDDTLSILNRLERDTPEYFSCEMCNILHRYDGSESFGLSVSEREKTCRLPCVQTRRWFSTSCTMRTHFGITYTQYEFSFLHLRLAMKRFHYGPRSGISTDSLSYTQVRHYPMQSVYPELLSLFSAEAQICPDPLGLYIRMQDIVLVEELDDLIFRQGRSRIHSDPLDNLMPCVDGFLLNFITPTVESLRNGGKASFTYNCQMCNTDIQIEIGEFDSKIAVVLTRWVNLGPGLTQDDILWNTQVIAPYSDSWIDLDDPRHLLTSPRLCFEEMAPQSFEDLRSRNLSHLENQQFKNGKPFTKAGGNRWYIAYKEPSKKTGSRLLRSLLSVLAISRDKGTVTRRNKRKLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVT7</accession>
    <name>A0A0G4PVT7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40/YVTN repeat-like-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S055g000031</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat MORG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793188">
        <property type="protein sequence ID" value="CRL30616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PVT7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PVT7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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    </evidence>
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        <source>
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    <sequence length="333" mass="35185" checksum="B7F77B89AA8281AA" modified="2015-09-16" version="1">MPRTIFPTRHIHTLKTHNGPVNAVTFSSSGGTYVLTGSSDRAVHLSRAVPNNSNSQTAVETTTPIQKYEAHGYSVLDIAVAADNARFASVGGDRQVFLWDVEQGITTKRWSGHNSRVEAVQFAGDGDSVVVTGSADTTINLWDTRSSSYKPIQTLTEATDTVSTLHVHMGSYSIASGSYDGHARIYDVRTGKTTVDVLAHPVTSVRCSSDGNALLASTLDGHIRLLDRMDGKVLSAFSGEKTVAGGIGKPKYSYRNSELRVRSVFAMGDAVVLSGSEEGTAGAAAFAWDVVKGEVIAAVPVGEKVKAVSCVAWNEGVGDWAAGCSDGTVRVYG</sequence>
</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="138" mass="15526" checksum="9BC888D993FDABFB" modified="2015-09-16" version="1">MEEIANIVRQIGQQQGENLYLRTCYTLFKHLQDNAGEAREDLLRLHQSGASVSSDDAFSPIYRVAHELRISVDALVCQARQAQSACEEFCQLEPSFSALEAFRFTDTTQTPDTPETTAHEACDSPRSMQFVIFPVEIP</sequence>
</entry>
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    <accession>A0A0G4PXP2</accession>
    <name>A0A0G4PXP2_PENC3</name>
    <protein>
        <submittedName>
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        </submittedName>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </location>
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        <location>
            <begin position="108"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="129" mass="14359" checksum="1546115B48FD1DC1" modified="2015-09-16" version="1">MDPSEILRTIATLNTRAVRAEKIIAKYEHDLAIARHTLVDTSKELDDTVKVAELLYSVNSRLGAVADYLLREQGMALGDREPKSVEVLINSLLQQTEAEQRPNPTNKSRIIARSGSSRSTDIENTIITQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PXY0</accession>
    <name>A0A0G4PXY0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger, CCHC-type</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">PCAMFM013_S067g000007</name>
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
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            <taxon>Pezizomycotina</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Dupont J."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="339"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="5">
        <location>
            <begin position="883"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="6">
        <location>
            <begin position="1355"/>
            <end position="1502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="78"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL30999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1671" mass="188861" checksum="583298F697FDFE0C" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PY24</accession>
    <name>A0A0G4PY24_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AMP-dependent synthetase/ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S098g000004</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793229">
        <property type="protein sequence ID" value="CRL31261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PY24"/>
    <dbReference type="STRING" id="1429867.A0A0G4PY24"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="AFD_class_I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
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        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="66"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL31261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="562" mass="62400" checksum="61CF35D50EE1FB62" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PYP3</accession>
    <name>A0A0G4PYP3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S105g000001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793236">
        <property type="protein sequence ID" value="CRL31288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PYP3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PYP3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="2">
        <location>
            <begin position="22"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL31288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="92" mass="9914" checksum="E4DFD3C3D492B451" modified="2015-09-16" version="1">MPDEKHDVPPISGSGASPLSQPAHTLPYEAVIKELGTEVDEGLSPEEASRRLQEYGPNKLDEGEGVSVIKILVRQVANAMMLVRPPSIYSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PZE2</accession>
    <name>A0A0G4PZE2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cys/Met metabolism, pyridoxal phosphate-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S4Jg000057</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793313">
        <property type="protein sequence ID" value="CRL31535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PZE2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PZE2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003961">
        <property type="term" value="F:O-acetylhomoserine aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071269">
        <property type="term" value="P:L-homocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000035">
        <property type="entry name" value="O-succinylhomoserine sulfhydrylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797">
        <property type="entry name" value="HOMOCYSTEINE/CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797:SF2">
        <property type="entry name" value="HOMOCYSTEINE_CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL31535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="472" mass="51403" checksum="C9226C06237E7CA3" modified="2015-09-16" version="1">MLEKPALQRFETLQLHAGAFPDALNSCSVPIYTTAAFGFNNAEHGVRLLNVSEFGNIYSRITNPTVSVFQNRMAALEGGVAACAVASGSAAVSMTLMALAGIGDNIVASFHVHGGTLHQFKVLAPQLGIESRFVTSNDPEDFRSKIDEKTKFIFVESISNPKYVVPDLEALAKIAHSKGIPLIVDNTFGCAGYFCRPIDHGADIVLHSATKWICGHGTTLGGVIIDAGTFDWGAQDDKFPQFHVNGAEEGSGELSLWNMFGSRAFAIRCQFEVLRDIGSSMSPQAAQQLIIGLESLAVRCDRHTSNTRALATWLEQQPSVAWVRYLGNEDHPSHKNAERYLHRGYGGVFSFGIKGGKQAGFKLCDGLKLIINTANLGDSKTLVVHPWTTTHQQLTDAERLDAGVDEDHMRLSVGIEHIDDLKDDFCQAFASMNETTKASANSVKQNSHIEEQKRMVRTLFGSRDPLPLSVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NSK3</accession>
    <name>A0A0G4NSK3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S001g000003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NSK3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL17043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="53" mass="6221" checksum="1D0406485EA0B118" modified="2015-09-16" version="1">MANEHELTPVDTDARLNGIVRRLVFPYQLFLRDRIFWPPAKNKHMSGTTPITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NSS2</accession>
    <name>A0A0G4NSS2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S001g000096</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NSS2"/>
    <dbReference type="STRING" id="1429867.A0A0G4NSS2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF16">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL17136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="300" mass="32406" checksum="18784A842F084A6C" modified="2015-09-16" version="1">MESSMGEHGAFKPAPAAQSQNKPGLESIMTEPSESTKLEGLHGFAEYAGSGKLKGKNALITGGDSGIGRSVAILMAREGADITIVYLPSEQPDAETTKNSVEQEKGVCLLIPGDLRDRNQCRRAVDEHVKKVYRYGTINILVNNASKQYLCPEFENIDLDKTEDIFRTNIVQMIAMAKFALPHMTRGDSIINTSSVVTFRGSGTMIDYAATKGAIIGFTRSLGTYLIPKGIRVNAVAPGAIYTPIQVDTRKPEQMEGWGHKVGLGRPGEPSEVATSFVFLASADASLYYGQVLHCYPLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NTA8</accession>
    <name>A0A0G4NTA8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S001g000159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NTA8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL17199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="66" mass="7406" checksum="CDA689DCCD9F5969" modified="2015-09-16" version="1">MKLPRSAWSWSAFQVDTALFMYGGVSTVAIPVEAITTPAPKVKEPRPLQRSKSKRKSLKRSLSKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NTI3</accession>
    <name>A0A0G4NTI3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S001g000377</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NTI3"/>
    <dbReference type="STRING" id="1429867.A0A0G4NTI3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20615">
        <property type="entry name" value="CYP_GliC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF167">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE GLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL17417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="510" mass="58154" checksum="90574430C3CAEC72" modified="2015-09-16" version="1">MSVANWVSLALVLGGLYYGVRIYGLWILETTVSLYLETFNSGVSSQGKPISGPKWEFPNGTVIERFLNGRVNSEKWRQYGPVYRIWSGPHPEIVITTPEDLKYFAADSSNHGKPPNSNMGWFLGELLGQCMGLLGGQDWTRVRRIFNPPFTHTAAVNQIEVIENAARRYVEELPLTTGNSQTTSTEKTGRSFTIPVVKTFTKFPYFLTAQSIYGPMTEKEEQMLWTVTESRLSLNPYMFGGGPYRFERGAKGFDSAAVQKLREYNREWHDFNAGMMKVRRARGERTAIVSYWEEYENGNLTLEELLHTLDELLMVNLDVFTHVITWFITLVADHEEIKRELRDEVMASKDNLLGYLAQTDTHLHRCFYESMRIRPFTIFTIGECAPTVKNFNGILVKPNTQVLVDVLGLNIRNPFWGANSEAFNPSRFKAIKQSDLRYNLHVFGFGSRKCMGQYLAGHIAKALVVHLFHQYEVLVSDGRDGANYDTDKSSWTPKADASLQLTRRDVLESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NTJ7</accession>
    <name>A0A0G4NTJ7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S001g000321</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NTJ7"/>
    <dbReference type="STRING" id="1429867.A0A0G4NTJ7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF110">
        <property type="entry name" value="UBID FAMILY DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="29"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="284"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="293"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="338"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL17361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="394" mass="44843" checksum="8BC54A4908C5082B" modified="2015-09-16" version="1">MGNVSPTPNQLFTEAIVFWSIGLVIYIGRVVARIIANGSYKQFFVDDYVMAATFAIYTTLLVLIQISARYATNLMDPKDYDQVLADPKQVSDRIYGSKIVIGLEQCMLISTWGVKTCMLMLYWRITQNLKSNLYIKILAVYVAVGFVVIMVTYYAVYCRPFSQYWAMPVDNMQCATYQHYSITQAVFNISSDAVMFAIPIPLLIKAQLKRRRKVVLIGVMSLGLFTIIAAILNKYFNFASPLTTTYQIWYIREASTAIYVANLMCWWPLLRKLFGVKAFQYNSNRAQRPGNPDNQNNDSSGCDSNNSQSRPSFASPRSWKPPFRRGNKSTPPGKYSGTKRSSTEPINRSNNEFVSDMHRVEAVPLESFATKEHRRTDTWTTQGSINTLEKQCDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NU03</accession>
    <name>A0A0G4NU03_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH:ubiquinone reductase (non-electrogenic)</fullName>
            <ecNumber evidence="2">1.6.5.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S001g000512</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a quinone + NADH + H(+) = a quinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:46160"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.6.5.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a ubiquinone + NADH + H(+) = a ubiquinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:23152"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.9" evidence="2"/>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NU03"/>
    <dbReference type="STRING" id="1429867.A0A0G4NU03"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) (non-electrogenic) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF47">
        <property type="entry name" value="EXTERNAL NADH-UBIQUINONE OXIDOREDUCTASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="12">
        <location>
            <begin position="113"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="External alternative NADH-ubiquinone oxidoreductase-like C-terminal" evidence="13">
        <location>
            <begin position="510"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="453"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CRL17552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="578" mass="64892" checksum="614A6ACF0F8E2252" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NU58</accession>
    <name>A0A0G4NU58_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Integral membrane protein SYS1-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S001g000563</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NU58"/>
    <dbReference type="STRING" id="1429867.A0A0G4NU58"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019185">
        <property type="entry name" value="Integral_membrane_SYS1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952:SF0">
        <property type="entry name" value="PROTEIN SYS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09801">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="154"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL17603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="205" mass="23147" checksum="5A23F207A6C040E7" modified="2015-09-16" version="1">MSARRRPQARSRTELPPLKIVRKILLLQLAYYACATVLILFTTIVYGAPFSLDLVFGWDSLRGDTTIGWMLGLVWMLNCFISVIFLLVFVSRSKLVPDFALTIHFLHLIATTLYTHSLPSNLLWWGLQFSSAAMMTFLGMWACQRRELEPIKFGGHRDSTQAGPSSQASAGDGQQESSFGRGRGRERSLQEYEMDDMKHTGEHAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NU89</accession>
    <name>A0A0G4NU89_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit SPC19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Outer kinetochore protein SPC19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S001g000617</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex SPC19 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NU89"/>
    <dbReference type="STRING" id="1429867.A0A0G4NU89"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013251">
        <property type="entry name" value="DASH_Spc19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28262">
        <property type="entry name" value="DASH COMPLEX SUBUNIT SPC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28262:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT SPC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08287">
        <property type="entry name" value="DASH_Spc19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="95"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CRL17657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="179" mass="19507" checksum="DB0288C560A6B686" modified="2015-09-16" version="1">MAASLSSSVTSLQSSLQILDNSISTLDAGVNDFPRLCKVLQTTRHFELLPEPTLREAQQSLLDEITPSIAHLLTLSSNHVEKLARREQGLKAKCDLQEGRLSSTPEGRSSATRSQPQGSSLRGRLAGSGASSSNNAAASKAAELRRLVQKKERLKFAVDRLELQSTQKQRQLRKSMAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NUI9</accession>
    <name>A0A0G4NUI9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S001g000681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NUI9"/>
    <dbReference type="STRING" id="1429867.A0A0G4NUI9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005194922" evidence="2">
        <location>
            <begin position="22"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL17721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="569" mass="57128" checksum="ECAB929532B4C55A" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NUV4</accession>
    <name>A0A0G4NUV4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Peptidase M13, neprilysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S001g000803</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NUV4"/>
    <dbReference type="STRING" id="1429867.A0A0G4NUV4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004035">
        <property type="entry name" value="Endouclease-III_FeS-bd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00764">
        <property type="entry name" value="ENDONUCLEASE_III_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="12">
        <location>
            <begin position="108"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="11">
        <location>
            <begin position="555"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="768"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="791"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL17843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="808" mass="90741" checksum="76F1C30D0EEE3523" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NV51</accession>
    <name>A0A0G4NV51_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S001g000900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NV51"/>
    <dbReference type="STRING" id="1429867.A0A0G4NV51"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042777">
        <property type="entry name" value="Sen15_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018593">
        <property type="entry name" value="tRNA-endonuc_su_Sen15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28518">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28518:SF1">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09631">
        <property type="entry name" value="Sen15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA-splicing endonuclease subunit Sen15" evidence="3">
        <location>
            <begin position="166"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL17940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="219" mass="24789" checksum="D4D156C579AB6780" modified="2015-09-16" version="1">MADSQEPTKRPNASAITEHITEKGYDSPHLATSAQVQHNLEHQHLWTSIIGYVIPGRADDSNTLSKDSRQPPKEPIPLLSGYPPHRVYTHPDEQLYMLENGIREDDLAPERLFVVPTTQGQPWTLRHMATVFDQLSEFKQKVEEQDRSVNPSVQPGAEGSDPEKAEKLAQYYDKKEQARLTEEWGTQRFLLAMVDKGMGGDGTVAYYVVHEGEVKPRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NV65</accession>
    <name>A0A0G4NV65_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S001g000923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NV65"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41252">
        <property type="entry name" value="BLR2505 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41252:SF1">
        <property type="entry name" value="BLR2505 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="22"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL17963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="147" mass="16344" checksum="E77E2519CABE3EF4" modified="2015-09-16" version="1">MASTPGYTPRAVLDAFYEAERAYMSAAPEARDFSGIAATLAPDVRLEQTPALPYAGVYIGPQGIKDWSTRMGDYFDIVDVQNPEIFERPGSDRVLVLSNIHLRVRSTGQEMDFPFCQAFTVDLEKGLILEIRPFYWDVAAVNAALGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NVC3</accession>
    <name>A0A0G4NVC3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S001g000960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL18000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NVC3"/>
    <dbReference type="STRING" id="1429867.A0A0G4NVC3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF274">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00440)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL18000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="259" mass="28269" checksum="6D9D573281948774" modified="2015-09-16" version="1">MVRILITGSTDGFGLEAARQLVQRNHTVYLHARNQDRADEVKAKCPGAAGVLVADLTSVAETRKLAEEANAIGVFDSVILNAGLLYGPFRKTLDTTVPAMVFVNVIAPYILSCLLKQPKRLTFIASVLHREANTDVEDIFWLERGEKDFQDFPAYCDSKLHVMLLANAVARRFKGTSVTSVHPGWVATKLGGQGATDKLEDGVETYVMLAEGDYDQSLTGVYFEPKRKIGEALPVTADENLQEVVVKACEDITGLKLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWB4</accession>
    <name>A0A0G4NWB4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S002g000238</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWB4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05672">
        <property type="entry name" value="M20_ACY1L2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000004">
        <property type="entry name" value="Peptidase M20 domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF0">
        <property type="entry name" value="XAA-ARG DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="3">
        <location>
            <begin position="196"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL18368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="437" mass="46717" checksum="F1720BD89BF0D7AA" modified="2015-09-16" version="1">MTAITLPHSHENGDAVSHGQDAEDIQDLLQIIDSQSQQLWEINQKIHSNPELGFKEFLAHDNITSMLETLGFEVTRHAYGLDTSFVAEYGQGGRVVAYNAEYDALPGIGHACGHNLIAMMSIGAFLGVAEALKQQKIPGRVRLVGTPAEEGFGGKIPIINAGAYTDVDACMMVHPGPFTECPGFTGDAYMPTLASLKFTIRFTGKTAHAAMAPWEGTNALDAAVLSYSGIGVLRQQIHPCNRVHCVISEGGLRPNIIPGSSALDCYIRSPSVAMAEELFLRVENCFKGAALQAGCTMEVQRHNTYADLRPNKPLATAYAQAMAQIGTEVKCDLNSSGVPGSTDQGNVTYECPGIQAYVGIPAGPGANNHTPGFTAVAGSKESHELCMHAAKGMAITGLNMLKNNEFAKQVKSDFEEDKIRRSVDSELRMLAGNAGFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWF4</accession>
    <name>A0A0G4NWF4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PCAMFM013_S002g000317</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent RNA helicase involved nonsense-mediated mRNA decay and ribosome biogenesis through rRNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Associates with polysomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWF4"/>
    <dbReference type="STRING" id="1429867.A0A0G4NWF4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17966">
        <property type="entry name" value="DEADc_DDX5_DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 14 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="18">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="169"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="372"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="527"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="527"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CRL18447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="568" mass="60365" checksum="6487EFB0118AB22B" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NY36</accession>
    <name>A0A0G4NY36_PENC3</name>
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        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PCAMFM013_S002g000759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005194875" evidence="1">
        <location>
            <begin position="19"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL18889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="63" mass="6654" checksum="CC14640BF9B1BC02" modified="2015-09-16" version="1">MKLTTFITALSFSALVAAAPVPLNNRGNLLPTPMQTVEKLFPGSGIPQLAGKLQKTFDISSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYA5</accession>
    <name>A0A0G4NYA5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleosome assembly protein (NAP)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S002g000920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
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        <property type="protein sequence ID" value="CRL19050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleosome assembly protein Nap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1500">
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    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
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        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="137"/>
            <end position="173"/>
        </location>
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        <location>
            <begin position="350"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="352"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="396"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL19050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="410" mass="46570" checksum="E5D0C85907FAAAB8" modified="2015-09-16" version="1">MSEPIRNKKADFPVAPTPQNTPANNAPISSHAQQPGVSSIEEESLDKAAAASLFARNPALVSMIQGKLGQLVGRSSGYIESLPPSVRRRVAGLKGIQKEHSKLEAQFQEEVLELEKKYFGKFTPLYERRSTIINGGIEPTEAEVEAGKEDEESDEEEETKEEPKKEEGEAANGIPEFWLSAMKNQISLAEMITERDEEALKHLTDIRMEYLDRPGFRLIFEFSENEFFTNKTISKSYFYKDESGYGGDFIYDHADGSQIDWKEDKDLTLRLESKKQRNKNTKQTRVVKISVPTESFFNFFSPPQPPAEDDDSVASDIEERLELDYQLGEDIKEKLIPRAIDWFTGEALQFEELGEDLDGDEFEDDDDEDEEDEDEDEEDLGSDRDVDEEDTDEEDGTSKPKKEAAECKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYQ0</accession>
    <name>A0A0G4NYQ0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S003g000003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NYQ0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195252" evidence="1">
        <location>
            <begin position="20"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL19212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="89" mass="9752" checksum="96BA0312D80934F5" modified="2015-09-16" version="1">MLTRIWILFLSATLEQTHCADIIGGPSGLGDGHILPDWGSLGREQSFSPMTSRKAPRPVRIACKGARLHPAYGSGKGDVRMQTPEYHHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0W1</accession>
    <name>A0A0G4P0W1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable cytosolic iron-sulfur protein assembly protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CIA1</name>
        <name evidence="6" type="ORF">PCAMFM013_S003g000711</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat CIA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P0W1"/>
    <dbReference type="STRING" id="1429867.A0A0G4P0W1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03037">
        <property type="entry name" value="ciao1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028608">
        <property type="entry name" value="CIAO1/Cia1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
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        </location>
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        </location>
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        </location>
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        <location>
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        </location>
    </feature>
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            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="454" mass="50055" checksum="62EC6DDCE8FE29EC" modified="2015-09-16" version="1">MSPKVTITHLSDLTPPSQERTWLTAPHPTLPIVATCSSDKTIRVYSLTNFTLLSTITGGHKRSVRSAAWKPHMSGESVLATGSFDATVGIWRRWDSYGQEDGVGLGMNSVDKQTPTDTLTEAPNGTGADTADREEDEEEWRFAVLLDGHDSEVKSVSWSASGMLLATCSRDKSIWVWEDLDDGDNNFETVAVMQEHGGDVKCVSWHPSEECLASGSYDDTIRLWREDVDDWGQVACLKGHEGTVWFLDWEGEETDGKWNGPISESVSESEMSALQAQWRSQRALSGPRLLSCSDDRTVRVWRRQPKESQQTGALSSAVTGIPSIIRPTGTDEVWEEDAVLPHAHELPVYAVAWSKRTGLVASTSADGRIAIYEERFVPSEQEQQQADSDAMDTTSGDVLRTEWVLVGVQDGAHGIYEINHVAWAKRADRGSDGEEEVLVSTADDGSVKVWTVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CRL20042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="53" mass="5422" checksum="0E12DFA6B13628D7" modified="2015-09-16" version="1">MATGRPEGRAQSPAHLRVGLGWASASMPTARLSLLPHPTKTTCAIATATADPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P1F2</accession>
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    </protein>
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        <name evidence="9" type="ORF">PCAMFM013_S004g000092</name>
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        <lineage>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF07651">
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    </dbReference>
    <dbReference type="Pfam" id="PF01608">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAT-like domain"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF109885">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="7">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="I/LWEQ" evidence="8">
        <location>
            <begin position="799"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="255"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="297"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1001"/>
            <end position="1028"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL20152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1042" mass="118300" checksum="4719D23908BCB341" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P1V9</accession>
    <name>A0A0G4P1V9_PENC3</name>
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        <submittedName>
            <fullName evidence="2">Spherulation-specific family 4</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PCAMFM013_S004g000242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4P1V9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Spherulin4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040:SF7">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12138">
        <property type="entry name" value="Spherulin4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL20302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="299" mass="33052" checksum="DF9FA23DD5E8D92A" modified="2015-09-16" version="1">MSDPEKHVSKRTCLKSKRSRFILAIVVLIVIIAAVVPSVVVTTLKKNNMGPKAKVFVPLYVYPAPEAWAPLENVISTHPDVNFTVVINPGNGPGPDSLPDGNYTREIPKLTAYANVRLLGYVYTSYGKRNVSAVRKDIQTYADWPTNSSNPNLAVRGIFFDETPQQYEAQTLTYLQGLTDFVKDLKDLGPDQFVVHNPGAVPDSRYLATADSTVVFEAAYTTFQERQGAKLFSNIADSNRTQLCAIVHSVPDAVEGKALRSLVKQVRQVADEVYITHLSTDYYASFGAKWTEFVDLMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P1Z2</accession>
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        <submittedName>
            <fullName evidence="9">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
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        <name evidence="9" type="ORF">PCAMFM013_S004g000266</name>
    </gene>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793137">
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    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4P1Z2"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
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        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF82">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="13"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL20326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="680" mass="76682" checksum="E2615E3FFA4695BC" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P1Z8</accession>
    <name>A0A0G4P1Z8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-NAD/AcoX kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S004g000276</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P1Z8"/>
    <dbReference type="STRING" id="1429867.A0A0G4P1Z8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000005">
        <property type="entry name" value="NAD+ kinase Utr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000025">
        <property type="entry name" value="NAD+ kinase Utr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF0">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="51"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="128"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="600"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL20336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="630" mass="69570" checksum="81435542C15A7F5A" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2G6</accession>
    <name>A0A0G4P2G6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S004g000384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P2G6"/>
    <dbReference type="STRING" id="1429867.A0A0G4P2G6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.200">
        <property type="entry name" value="LURP1-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007612">
        <property type="entry name" value="LOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038595">
        <property type="entry name" value="LOR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04525">
        <property type="entry name" value="LOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL20443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
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        </source>
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        </source>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM14 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL20967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P3T9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1740">
        <property type="entry name" value="Transmembrane protein 14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005349">
        <property type="entry name" value="TMEM14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044890">
        <property type="entry name" value="TMEM14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668:SF53">
        <property type="entry name" value="TMEM14 PROTEIN HOMOLOG YJR085C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 14, 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03647">
        <property type="entry name" value="Tmemb_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL20967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="108" mass="11406" checksum="C67F37AEBC4FB305" modified="2015-09-16" version="1">MAEHPSFTLAALLPIGGTVGFLRTRSAPSLIAGVGLGVSYAYSGYLIKENKDYGTELALGNSILLLGSAIPRIVKTKARAAMPLALGAAGLLASFYYQKKVREFRFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P4A8</accession>
    <name>A0A0G4P4A8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S005g000298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P4A8"/>
    <dbReference type="STRING" id="1429867.A0A0G4P4A8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031942">
        <property type="term" value="C:i-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24145">
        <property type="entry name" value="Mgr3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040201">
        <property type="entry name" value="Mrg3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28142">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE I-AAA PROTEASE SUPERCOMPLEX SUBUNIT MGR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28142:SF1">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE I-AAA PROTEASE SUPERCOMPLEX SUBUNIT MGR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL21134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="485" mass="53379" checksum="CC1B59CFCC4665ED" modified="2015-09-16" version="1">MFRAASRRTSVHAAKLLQQQPKSLARSIYINSTTRPTLQPRINNGKPLASPYISGTRHLTIMQKIGRKYREASKGIWRKNPVLMPLAIFSVVGGAFIFAYISYVELTRVGPQYHKFPPPVADALRTAIYYTEIDLNPAKAMKAYREALHIAFEMGIHPYSDEILGIKLQVAMMLEKAGLVKPAIDVLERTKNETLAWVEEVTAGNAAAAAEKVKQAQAQVQKTPANVQVDTEAIKETEEDLKAMAQYEARQRDKALKKVVGIAMKLGELYSSEYIQDEKKAEVAQVAAVEICLKEMHRRQKLGLPVGSSSSGEGSDGEAWLNLTEIATALAELAATYTAKERYELAMPLYMRALDLIRAAEGTSISCKQVVLLNDVATALVGQVQLPAKSQPQQPVTAEQTVEAAQKWAEKAIEVAAHIEPPIRDEECDITCVVATYNLGELAELQKKPAVAKQRYTEAKALADGIGYEEGSMMAKEALKRLGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P4B1</accession>
    <name>A0A0G4P4B1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Phox-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S005g000334</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P4B1"/>
    <dbReference type="STRING" id="1429867.A0A0G4P4B1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07627">
        <property type="entry name" value="BAR_Vps5p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06861">
        <property type="entry name" value="PX_Vps5p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000013">
        <property type="entry name" value="Putative Sorting nexin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000022">
        <property type="entry name" value="Sorting nexin 3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035803">
        <property type="entry name" value="BAR_Vps5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037868">
        <property type="entry name" value="PX_Vps5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="13">
        <location>
            <begin position="167"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="544"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="455"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CRL21170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="574" mass="62736" checksum="46AD15AD7BEB94A4" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P4N8</accession>
    <name>A0A0G4P4N8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S005g000445</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P4N8"/>
    <dbReference type="STRING" id="1429867.A0A0G4P4N8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL21281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="309" mass="32636" checksum="0DB37EF742992827" modified="2015-09-16" version="1">MSADTSAGASEDQRASLTSRVLPMMTLSEGSNPLTRPLAPVPSTSAQERAKARFQVQGKAIVTGGAGALGLISAQALLEHGLSSLCIMDLPRTLETSSEEIQSLASKFHSVNITKVPLDVTSIESIEAAFEQANKTMEGIDILCCFAGIPGCQPSLSVTPHQFNKVIDVNLNGSFFCAQAAAKRMESSGKGGCILFTASMSAHYTNFPQPQAAYNASKAGVAHLTRNLAAEWAVHGIRVNSISPGYMDTILNAGDSLADIRKIWDYRCPMGRMGDPEEITGAVILLCSQRAGRYITGADIVIDGGTLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P4X0</accession>
    <name>A0A0G4P4X0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S005g000514</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P4X0"/>
    <dbReference type="STRING" id="1429867.A0A0G4P4X0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001921">
        <property type="entry name" value="Ribosomal_eL8_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00882">
        <property type="entry name" value="RIBOSOMALL7A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="6">
        <location>
            <begin position="125"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL21350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="265" mass="29460" checksum="9882891EA853F2DB" modified="2015-09-16" version="1">MVPPTKSGKKTAALPYPQGKAGAGKKAAKNPLIEKRTRNFGIGQDIQPRRNLSRFVKWPEYVRLQRQKKILNMRLKVPPSIAQFQATLDRNTAAQTFKLLSKYRPETKAEKKERLVQEATAVSEGKKKEDVSKKPYNVKYGLNHVVGLVENKKASLVLIAHDVDPIELVVFLPALCRKMGVPYAIVKGKARLGTVVHKKTSAVLALTETRAEDKAEFAKLLSAIKEGYTDKNEDSRRHWGGGIMGAKANARIEKKQKALDAAIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P4Z0</accession>
    <name>A0A0G4P4Z0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
            <shortName evidence="12">DHBP synthase</shortName>
            <ecNumber evidence="3 12">4.1.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S005g000532</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="12">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the DHBP synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="3 12"/>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P4Z0"/>
    <dbReference type="STRING" id="1429867.A0A0G4P4Z0"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000002">
        <property type="entry name" value="3,4-dihydroxy-2-butanone 4-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF18">
        <property type="entry name" value="3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0318">Glutathionylation</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 12" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0686">Riboflavin biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
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                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">FM 013</strain>
        </source>
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    </dbReference>
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    </dbReference>
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            <begin position="16"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL22225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="79" mass="9207" checksum="E8CAAAC9EB5623AA" modified="2015-09-16" version="1">MTAEPNAPGHNKQYYEEEEQLLIVLKQLGGLSWSEIALRFNESVPEDRHRTASALENKWRQLQKTHHLVDLSHIFLEQG</sequence>
</entry>
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    <accession>A0A0G4P7H1</accession>
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                <person name="Abraham A.L."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL22266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="174" mass="19807" checksum="203F8BE1251B6B4B" modified="2015-09-16" version="1">MEQAIATGPSTPPEQTSLAWELGNIPVPPSFNTCAEDSVSFEELEVPSTNHKRNFPRPTKQISVQRSPTPMVSQKKSPRKLLPAISFVRNRHGIHSETSPKVPRRKRKHKAVTPSHGRKKRTNLQSMRTKMQKTPEKQSISSGHEKTRRTKLKPKGNKHRTEDTDEKDPSYICR</sequence>
</entry>
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    <accession>A0A0G4P7P3</accession>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        </location>
    </feature>
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            <begin position="126"/>
            <end position="172"/>
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        <location>
            <begin position="298"/>
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        </location>
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            <end position="11"/>
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        <location>
            <begin position="39"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
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        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL22338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="345" mass="37857" checksum="F0782252A5FB4C25" modified="2015-09-16" version="1">MASQTYNSSTRAGVKPSNKPTPSPNFADPNFDPADFLNDSLSPLTVASSQPNASRAPGSVPLTELSAQVQSLLSQISAQNIRLSSTLSQLTDEILRSGGRLAYEVEVLRGETIGLSETLTEVLRDDITNFVPEPSPEDGRKTEQAEDDAPTNEDESASPDDKNKPIVPTDPEYIKSLRTLNQVRSRLEDVVQTFGDAMSWPLPPSEISFSSSFISVSGPDLGPEGQDREEKGQEMMKKLRKEVTELLDSEGGGYAGLDAANRRVEALRTLATVWNTSAEEKARNRFVDSLANIVEDRRRTLDQADQNQRGQSKSRSEARRDSDSGAPAGGLFRNLQRLREEIYLE</sequence>
</entry>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="69"/>
            <end position="91"/>
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            <end position="139"/>
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            <end position="163"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL22366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="447" mass="50577" checksum="6E478613E4802D39" modified="2015-09-16" version="1">MYPWSERLNSWGRGTGLKVDALGLVTLLGAEEMDRSIGRLVPSIYLKYLPLLGAFVIAGNRFTTKKPGFVLYNISAGIMTTELAGWFSRWLQTQDFKQVRSIVTWHITERPCRWREFVVGFLLVGLPVHGMLIALTVLAADWWGFANVISMAISVAVRCMMVAQNQAGIDANIQKAQKEPQDYPAKRAKYDESMERLESHRQNGQAMEGVKIPIEPQDPNKIAKVIVLTEDSRVVTLAVPAYLPKLAFATNPQPPNRYIYQACQWIGWAAFAVHVISIGMAALYTQIVSVVVILVSTVLTAHRVGCEDSRIWESIRSYWGHEVQENSCWVSSKLKATVSIYPEEYMDWPELEENKPLTVHVGNEEKASQQWTRPIGPPDLESTPILTKKKDETRQDLLAWLDLTTEEDKVLTAWGLIPHSLGWQNAYREKKNIHHKRLGMIGLESTH</sequence>
</entry>
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    <accession>A0A0G4P7Y3</accession>
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        <submittedName>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Lacoste S."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793140">
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    <dbReference type="STRING" id="1429867.A0A0G4P7Y3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18345">
        <property type="entry name" value="zf_CCCH_4"/>
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    </dbReference>
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        </source>
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        <source>
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        </source>
    </evidence>
    <sequence length="1082" mass="119908" checksum="DA29282637DFC3C8" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7Z3</accession>
    <name>A0A0G4P7Z3_PENC3</name>
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            <fullName evidence="5">Indoleamine 2,3-dioxygenase</fullName>
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        <name evidence="7" type="ORF">PCAMFM013_S007g000406</name>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
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        <text evidence="5">Produces N-formyl-kynurenine through the oxidation of tryptophan.</text>
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            <text>L-tryptophan + O2 = N-formyl-L-kynurenine</text>
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            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
        </reaction>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
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    </evidence>
    <sequence length="478" mass="53119" checksum="B2FC22149FC7639D" modified="2015-09-16" version="1">MLPPVPNPSEFGITPDYGFLSPELPLEILPDTYYAKWENIIGNLHPLILSKRLQSAVDHLPILSVAHLQTDAEWRRAYVILVFILHGYVWGGNSPTERIPPQLTVPLFQVCERLELPPVATYAGVCLWNYKPIFSHEPATNLENLACLQTFTGSLDEQWFYLVSVAIEARGAPAIPVMLRAIAAARTGNTQIVTECLQRLAETIDETNTLLQRMYENCDPYVFYNRIRPYLAGSKNMGDAGLPNGLLYDDGHNPEYRQYGGGSNAQSSLIQFFDIVLGVEHRPTGTSRKDSESTGDTKSRNSFIHDMRTYMPGPHRRFLEQIDSVANIRSFVEARRGDSALCIAYDACLAMLRVLRDKHITIVSRYIILQSRSARQPSQSANPSLPKTTNLASAAPTDKKKLRGTGGTALIPFLKQARDETGEPAIDAWARRLLSNGPADKKFASLSKVGEQPDGHLEVVGLCGTWTAEENEGGICHW</sequence>
</entry>
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    <accession>A0A0G4P8G8</accession>
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        <submittedName>
            <fullName evidence="8">Str. FM013</fullName>
        </submittedName>
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        <name evidence="8" type="ORF">PCAMFM013_S008g000026</name>
    </gene>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">FM 013</strain>
        </source>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
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        <property type="entry name" value="Rcf2"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HIG_1_N"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
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        <location>
            <begin position="89"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="257"/>
            <end position="269"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL22597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="274" mass="30280" checksum="D63308477C80953C" modified="2015-09-16" version="1">MKILTKEQEEAHYRSVLKGGTVGGLLGLAGGFAGVLLASRRYHTIRNLTLPMKAFLVTSSGTFTGIIAADHASREHENEQNATYKWYENREERLQAEQIRGLSFTDRAAAFARREKYKIITATWVASMVGSFALVSRIPGLSGQQKLVQARVYAQGLTLGVLCASAAFEISDQRRGRGLLDSKKKADAAKNKVEPVEEEQPVHQGGSPNQGDLWKDMVAAEEERLSSKHQSLYDHHEKQQAAGAEGKEEKSEESDDDSKTEKKDTESKDKKKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P8L1</accession>
    <name>A0A0G4P8L1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S008g000038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lcsJ thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P8L1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051490">
        <property type="entry name" value="THEM6_lcsJ_thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475:SF4">
        <property type="entry name" value="PROTEIN THEM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="230"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL22609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="341" mass="38226" checksum="9A9D81205A3A609F" modified="2015-09-16" version="1">MENTREILAGVMSLASWKNLALLLAVINLKSLPFVWHFRLLYHFVGNLRLKPGAPLLPKGRLIVDSRGKPTHPIFVPCMVTSRTPLLETDYNLHKSNSTYFTDLDVSRTALVTRIYSPGVGNVSKELDQEFLAASKKEGKPAPRRKPVSIVLGSVYCTFKREIKPFELYEMHSKVISWDAKWMYILTCFMRPAPRNGGEKVVLAVAVSKYVVKKGRLTVPPGRLLRASGFLPAPPPESEAKPALAEADTSAEASDVGTPASGEGITAMEGVDGSLVREVLKMNDDQIPSQETLDKQQKENTDSWNVEEWTWERIEQERLRGLEVVDGYTNLDTKLFEEWVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P9S5</accession>
    <name>A0A0G4P9S5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S009g000002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P9S5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL23062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="219" mass="24841" checksum="DC1176CB1A58FC42" modified="2015-09-16" version="1">MPAPIEITDPLAVVRDLYDDEKLVVDDFERHASHCRNCSHAVQTYKDGLALCESGNTRARTLRNYLYSQNGKHFSTVDFESGKSTRVKLPRDAFAARELLTALEQGMRIREKAVVIQKPVQPVQPTQSSSYDRTYPIPARKVSGKQTRPRSMSPEAYQLVERAPRLSRSPTSIVYCSPGGSSSRPSSSRGSLYSVDRQERVERHYETPRRYIEGSPKHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PA19</accession>
    <name>A0A0G4PA19_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">2-oxoisovalerate dehydrogenase subunit alpha</fullName>
            <ecNumber evidence="9">1.2.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S009g000103</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the BCKDHA family.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="9"/>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PA19"/>
    <dbReference type="STRING" id="1429867.A0A0G4PA19"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000015">
        <property type="entry name" value="2-oxoisovalerate dehydrogenase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050771">
        <property type="entry name" value="Alpha-ketoacid_DH_E1_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="10">
        <location>
            <begin position="96"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL23163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="448" mass="50396" checksum="18900F4B5B49ADCF" modified="2015-09-16" version="1">MSLKLLTRNGLRSQPITTARIVPARRWSSSISQLPGSDSVRFPGAVNSKFTSEMAFLKASDLPAIPTYRVMDSDGYQVDKTRPAPNVTNEEVLTWYKNMLSVSVMDVVMFEAQRQGRLSFYMVSAGEEGITVGSAAALTPDDVVFAQYREAGVFQQRGFTLKNFMSQLFANCNDTGRGRNMPVHYGQNYPRMHTISSPLATQIPQAAGAAYALKLQDLQNPNRDPRIVACYFGEGAASEGDFHAALNIAATRSCPVVFICRNNGYAISTPTLEQYRGDGIASRGVGYGIDTIRVDGNDVFAVNEAMREARRLALSDGGRPVLIEAMSYRVSHHSTSDDSFAYRARVEVEDWKRRDNPIIRLRKWLENQGIWSEEQEKQTRDEMRKAVLKEFGEAEQEKKPSLREAFADVYEEITEEQREQMAELKRILETYPDEYDLRPYKDGINGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAH1</accession>
    <name>A0A0G4PAH1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S009g000252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PAH1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PAH1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL23312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="142" mass="16064" checksum="6B6389C5997D9709" modified="2015-09-16" version="1">MPIIIISIIFDNYVGHVLLLSHIRTYVHHYSLLLFPSWGCIIHRAKENLKPSNVVLDDDGNAVLIDISGIGGVTHGWCAPEIRNEISPFELQFQTRQLNDIWAYRKLLREIVSNAGNSPFVGILKWVASYFTEGCSQQVESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAS4</accession>
    <name>A0A0G4PAS4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome b561/ferric reductase transmembrane</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S009g000356</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PAS4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PAS4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF1">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195189" evidence="9">
        <location>
            <begin position="38"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="10">
        <location>
            <begin position="221"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="387"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL23416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="416" mass="45086" checksum="25B82FF64037C9A7" modified="2015-09-16" version="1">MHSLIEDIYTTACGADRMGLHVSFAFLLGLVVKSALSQPFTLVVPGHDDIAYHVLETDATYIMITASKDVGWVSFAQGQDSSNSSNLAASNTIFVSLKEQYPTKAGSNLSNCQKIQGPPSVHDQTVEATIRCDDYPILNRLDTFTWAYEQDGIIHSGPMRVLETPNSDNVAMSGRDGLRRVVRSMSSQSAETSTVPSQSPSPEEIAALMAKYDRLTKIRTIHGSIMAITFVVLFPTFATLLHLLPSSKPVVKIHASLQAMSATLAIVGFGLGVYLNSEITIKGKHHQAIGAIVIILLVIVQPILGIRHHMLFRRTQRKTWLGYAHRWQGRIMLSLGVVNGGIGYNLSRTGPSGGPRGALVAYGVVAGIVYVCYFGMLAFKAFKQRQVSGGGKTDGTEGAGRPDTEEHTLTEMSTHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PB61</accession>
    <name>A0A0G4PB61_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Taurine catabolism dioxygenase TauD/TfdA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S009g000497</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PB61"/>
    <dbReference type="STRING" id="1429867.A0A0G4PB61"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="3">
        <location>
            <begin position="164"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL23557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="271" mass="30587" checksum="AA36DCF262FA7ECF" modified="2015-09-16" version="1">MTSMPACSTEVKLQREDGGTTSNEARGRTRSERRPEKPTSPTWGCKGTLSSPVKLSVFPDGFKTSGQHPPQYIRWFDPISISPRPIPGLQCGKLRIIASILLWTHRFTAEEIVEISDAADQFIQTGIPLTGISKANFPLPNLSQRLEELRQDLINRVRIYRTSACQYFHTDGADLVGLLCITKSLSGGESDIASTHYVFNVLQERDPDVTRTLCESNWYFDRKGEMSKGEEGWIRGSVFYLENDNGRSSPRVYRKVRSYERDIVSTFQLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBF1</accession>
    <name>A0A0G4PBF1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily, general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S010g000085</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PBF1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PBF1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="45"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL23647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="482" mass="52670" checksum="CE56EFFE343B2C4E" modified="2015-09-16" version="1">MAATESGKPSNFPQEETKNANAVVSRDVEEVIHSYRPSRWQSNITIISCYIANFSDGFQNTLANPTNVIFKQVLGADGFSSEMKTRMSNSVIVGAILGVVVFGYTSDMFSRRAGLLFTSSLVAIGTLMAALALQVHPSSNMLWYFVVVRGIAGFGVGGEYPPSAAAGIEESDWIMRKYRGPMFVSFTTLMATTAGPILMIIYLITLIATDNNLVIAFHAIYSIATLLPVSIIVLRLFMVDSSLFHYSNFKRQPKSWRLCLLLARRYWWRLLTTSLAFFLYDFINFPNSIMSSTIISSLVTDHNVRTTAIWQVILAVLPVPGVVLGAWLTNAIGRRWTGILGFAGYVVLGFVIGGTYSKLSQNIAAFVVLYGLLQAFGHMGPGATIGLISSESFPTAMRSMGYGVATAFGRTGAAVGTQCFTPLQDRAGNSSTFYLAGGVAILGMMVYYLLPESGDLDLEKEDKELNEFLMQHGFTTDVKEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBK6</accession>
    <name>A0A0G4PBK6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Opine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S010g000140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PBK6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141152">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051729">
        <property type="entry name" value="Opine/Lysopine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003421">
        <property type="entry name" value="Opine_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38015">
        <property type="entry name" value="BLR6086 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38015:SF1">
        <property type="entry name" value="OPINE DEHYDROGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02317">
        <property type="entry name" value="Octopine_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal" evidence="3">
        <location>
            <begin position="12"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Opine dehydrogenase" evidence="4">
        <location>
            <begin position="195"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL23702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="408" mass="44640" checksum="C167F15EBD87E36C" modified="2015-09-16" version="1">MAIENFDSVPTVTIIGAGPCGCAFAADLANRGKSVMLYAHPDHRGGTDMIEKNNGWLNAAGEISGKFQIKTTSDLYIAIRHSPFIVTTVPSYGQDTILTLLSQFDLRNHTLIINVGNFFYLSARSKINAHAILETDISPYATRIQGDTVFVKGCKKTLSIWAEPPNTTQVERLDPQAELGLRHKVEMIFSQKLVWCQNLLEVGLNNVNPVVHCPATLMNAGWIEATKGDFYFYAQGMSPSVSRVTEKVDKERLAISHAYGLEITPITAYMNQNYNNDREYSDYHDFASGSVVHNKTKSSPSSLNHRYLLEDVLYGLVPWYELGLKCGLASPTIRALIEMAAVVSGFDYFEHGRTLKSAGLGDATKDQVLHALGGPVDGTPSAHAPLSDSPIGNRLELHAPLQTAQVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCE7</accession>
    <name>A0A0G4PCE7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin-conjugating enzyme/RWD-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S010g000421</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PCE7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PCE7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000058">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="3">
        <location>
            <begin position="5"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL23983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="276" mass="30430" checksum="1C01D4858DED4D12" modified="2015-09-16" version="1">MATKAAFKRLTREYQNIQKDPTPFIVTHPSETNILEWHYILTGPPGTPYENGQYWGTLIFPPEYPFAPPAIRMHTPSGRFQPSTRLCLSISDFHPKSFNPAWEVSTILIGLLSFMTSEEMTTGSVSGSESERRVLAARSRWWNSTGGGSHVSATAGVTRTSKGINNVKAGDGGLKFRTEWPELDQENWAWMKEHRIDSATGQILPDPDAPAKCSPETSALRRRPNGSAPGIGSVVDGGHVAREAGQGWAGRNRIWICVAVFFGYALISRLLSDMRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCX3</accession>
    <name>A0A0G4PCX3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S011g000170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PCX3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL24176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="51" mass="5704" checksum="922DAB0E5690196B" modified="2015-09-16" version="1">MASASSPRPHGQPYGQHVKIDDRVAQPSMPLPKDGMTMWIALIWREGKGWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PD07</accession>
    <name>A0A0G4PD07_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vacuolar protein sorting-associated protein 26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S011g000128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
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                <person name="Bensimon A."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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        <source>
            <dbReference type="EMBL" id="CRL24677.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
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</entry>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793146">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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    </evidence>
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            <dbReference type="EMBL" id="CRL24832.1"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGE5</accession>
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        <submittedName>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Bensimon A."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793147">
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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    <accession>A0A0G4PK93</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <property type="entry name" value="LIPID-BINDING SERUM GLYCOPROTEIN C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12505">
        <property type="entry name" value="DUF3712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL26593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="339" mass="36612" checksum="36029FE483B7686C" modified="2015-09-16" version="1">MSSAKPEFVEEESHITPTPTKKSFGARLGAHFKKWWWVHLIIFIACFLIILLPVVYVAYPKIAQDAVNDSTLKITEMILSNPTPESFRLEQNQVLGSDSSYHPQIYAFNSSVSLAGEGPFAYVTVPAVKSKDGAEIHFEQNVALTDASAFGDFTTAVMLNEEISLNIYGRPGLKQGGLPKTTVTYNKTVVMKGLNQLKGFAVSEFFIMFPPVNGYGMNGTVIIPNASVMTIPLGNVTLNLELAGKSVGTTYLTDLTLKPGNNSVPMIGKVDQSAIISLLASKTNPYKDGIMPFDITGNATSTYNGKELPYFSKALAANKLSIKLDVKSALSAAGVNITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PLH2</accession>
    <name>A0A0G4PLH2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AMP-dependent synthetase/ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S021g000192</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793154">
        <property type="protein sequence ID" value="CRL27277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PLH2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PLH2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000008">
        <property type="entry name" value="2,3-dihydroxybenzoate-AMP ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43859">
        <property type="entry name" value="ACYL-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43859:SF4">
        <property type="entry name" value="BUTANOATE--COA LIGASE AAE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="39"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="480"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL27277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="572" mass="63242" checksum="7A6984B50F2F05AE" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PLX3</accession>
    <name>A0A0G4PLX3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S022g000092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793155">
        <property type="protein sequence ID" value="CRL27412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PLX3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL27412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="107" mass="11957" checksum="2210F1CDD49DE28B" modified="2015-09-16" version="1">MMGKFLVIGGPVTRLWLSEVARCTQRGFFEATAGECDELDTISYQHGMNGDCIDEDNYEKRLECSHCLGPSLSRQTPKDRGMPVVLYSARPFRGTAGECNEPEYNMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMK0</accession>
    <name>A0A0G4PMK0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S022g000051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793155">
        <property type="protein sequence ID" value="CRL27371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PMK0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PMK0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL27371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="144" mass="16426" checksum="B1480CBCBF6F1B0C" modified="2015-09-16" version="1">MLESKRSTTSRGRRDPLPKKRIEPEDQPDVATSDDSATESDDLDVSNLVQEIAKLRRDIRLRDEIHKEELLKAQAEFGAALAEVRHELQNLTDRPLTPQCHSEACSQNNHDAILREIQSLREDIYCSKGSRYHHVPSALHVSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMY3</accession>
    <name>A0A0G4PMY3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S024g000060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793157">
        <property type="protein sequence ID" value="CRL27805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PMY3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL27805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="34" mass="3854" checksum="14D6492834C04AF0" modified="2015-09-16" version="1">MDIAILTPELLWWIRGRFLSARLVPTSTSQNLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNT1</accession>
    <name>A0A0G4PNT1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Maltase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S024g000061</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="HG793157">
        <property type="protein sequence ID" value="CRL27806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PNT1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PNT1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000001">
        <property type="entry name" value="Maltase-glucoamylase, intestinal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1760:FF:000005">
        <property type="entry name" value="Putative alpha-glucosidase AgdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000138">
        <property type="entry name" value="Putative alpha-glucosidase AgdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000169">
        <property type="entry name" value="Putative alpha-glucosidase AgdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030459">
        <property type="entry name" value="Glyco_hydro_31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF133">
        <property type="entry name" value="P-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00707">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195498" description="alpha-glucosidase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="12">
        <location>
            <begin position="112"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="11">
        <location>
            <begin position="338"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="13">
        <location>
            <begin position="774"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CRL27806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1078" mass="118418" checksum="D027F717005175E6" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNY2</accession>
    <name>A0A0G4PNY2_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S024g000138</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="HG793157">
        <property type="protein sequence ID" value="CRL27883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PNY2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PNY2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF687">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="391"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="180"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="780"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL27883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="841" mass="93053" checksum="9CB6A5E1C801F14B" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PP14</accession>
    <name>A0A0G4PP14_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S024g000188</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793157">
        <property type="protein sequence ID" value="CRL27933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PP14"/>
    <dbReference type="STRING" id="1429867.A0A0G4PP14"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </source>
    </evidence>
    <sequence length="468" mass="53206" checksum="9CE8B5F19FE462EC" modified="2015-09-16" version="1">MAQSSPNFDNIQGDIWPGLSKKYEQFFFFQITSPDAFKPNLKRLLAHKKITTSNDAINNRKMIAKHRQEKPGVLHEIAAVNIAFTFKGMQKMYPEDGFKDDPYRKGMEGDMVNEGRDKIQEWDEAFKASNGGIDGVFFVCGTEKKVKETTAELAKLYFNEARGIKHVITLDGRERDGENYKHEHFGYLDAISQPRLTGFDEECKKGDGNYQFMSRPGRIIIGHDGEMGNEPKLMHGDWAKDGSYLVIRKYEQFVPEFNNYLKAESQKLHLTPDQLGARMMGRWKSGCPVELHPDQDNPALARMNEFNYNPESGSNCPFAAHMRKVKPRIDNRDRDMNDIMRRGIPYGPEVGPDEASATKLDRGLIFTCYQSSISNGFQEIQRQWINKNTFPDGKEDYIGDQNPGQDCIVGQLVGRPRNDRDKVLTTAICNGKGEHTSTSYTPFIQSHGGDYFFSPSISLLQAMTKADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQH2</accession>
    <name>A0A0G4PQH2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mitotic checkpoint serine/threonine protein kinase, Bub1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S027g000082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793160">
        <property type="protein sequence ID" value="CRL28393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQH2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PQH2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.430:FF:000003">
        <property type="entry name" value="Checkpoint serine/threonine-protein kinase BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015661">
        <property type="entry name" value="Bub1/Mad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013212">
        <property type="entry name" value="Mad3/Bub1_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030:SF4">
        <property type="entry name" value="BUB1 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030">
        <property type="entry name" value="MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08311">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00777">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51489">
        <property type="entry name" value="BUB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BUB1 N-terminal" evidence="2">
        <location>
            <begin position="64"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL28393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="331" mass="36541" checksum="5C054628C7E1B56E" modified="2015-09-16" version="1">MAASDDLVDFDIIEAQKENVQSLPGGRSARELARIFSAGSNGDKIPSPSPNGTRTINDAMRQEFESELQSIGESDDPLDVYDRYVKWTLNAYPSAQATAESGLLPLLERATKSFLSSSHYRNDPRYLRLWLHYVRLFSDAPRETFAFLARHQIGESLALFYEEFAGWLEGAGRWSQADEVYRLGMDREARPVERLARKYSEFQFRYDQRPQDTGPSSPALPTVRPALAAKMNPFATSDASADPQASRPPPQTGGAAKTKSGKPKMAIFSDADSAAPGPATGGSTKGWESIGSIRDRKKENEVEAKPWAGETLKVGKKAAPTQKMAIFRDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQY6</accession>
    <name>A0A0G4PQY6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWR1-complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S028g000084</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SWC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793161">
        <property type="protein sequence ID" value="CRL28531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQY6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PQY6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011421">
        <property type="entry name" value="BCNT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027124">
        <property type="entry name" value="Swc5/CFDP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48407">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48407:SF1">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07572">
        <property type="entry name" value="BCNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51279">
        <property type="entry name" value="BCNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCNT-C" evidence="4">
        <location>
            <begin position="271"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="149"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL28531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="351" mass="39083" checksum="481BB13D4535DAE1" modified="2015-09-16" version="1">MSNPPLPENQDLDEEAYDSAEDEDFELDAAPDDSDLSSDADETAEPAKKKRKTVTQSQLPKDAELDSGDEATIRKAREKKEKKTKGKKTKGKRARDSDEDDGDIDMDDDEGGTGGFVRTRAMKQQIQEEQRKPLARIDGATVDVNALWEQMNAPQGQSGLQPPQTQQIPESAPEHEPTKAPDQGAGDVEHKTGHAAHADQMIKIKRTYKFAGEWITEEKVVPKHSAEAKAFLSSGENGEYADEDAAAANTARNLRRPLRKISRFDPNPTGTIKKSWEKQLVADDKDARGPKINTVEKSRLDWASYVDSAGIKDELRTHSKAKEGYIGRMDFLGRMEDKREDERRAARLKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-11-27" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRW4</accession>
    <name>A0A0G4PRW4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA 3'-terminal phosphate cyclase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S031g000036</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793164">
        <property type="protein sequence ID" value="CRL28868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PRW4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PRW4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00875">
        <property type="entry name" value="RNA_Cyclase_Class_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.20:FF:000004">
        <property type="entry name" value="18S rRNA biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016443">
        <property type="entry name" value="RNA3'_term_phos_cyc_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03400">
        <property type="entry name" value="18S_RNA_Rcl1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF1">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="5">
        <location>
            <begin position="10"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase insert" evidence="6">
        <location>
            <begin position="205"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL28868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="402" mass="42259" checksum="E43F65FB95FFE261" modified="2015-09-16" version="1">MATSQPPLRFTSHHNLVYRLVLSTLTGRTVHISQIRSSSPTNPGLAPHEISFLRLLDAITNGSQMEISYTGTVLVYKPGLVTGSTAGTGASGGMITYEIPSNCNRGLSYFLIPLCLLAPFAKAPMKVLFTGPGVITSSTQTGDMSVDSVRTAILPLYRQFGIFNNIELRILRRSNTGPTGRGGGGEVQLVFGHQVRLPKTLHLMNAGRIKRIRGVVYSVGVSGSNNARMIETARGILNPLSPDTYIFSDVASAPLVPAPDKTNPQAKKKIGLGFGLSLVAESSTGCLFSADVASPPQGGQAPEEVGKQCAFQLLETVAKGGCVAPAAATTMFTLMTMGSEDVGRLQVGRDVIADPNVVQLARDLSKFGAPGWGIRDAPDNGDGDVIVSIVGRGIGNVGRKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PS30</accession>
    <name>A0A0G4PS30_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent pyridine nucleotide-disulphide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S034g000057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793167">
        <property type="protein sequence ID" value="CRL29259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PS30"/>
    <dbReference type="STRING" id="1429867.A0A0G4PS30"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053275">
        <property type="entry name" value="Agnestin_monoxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38688:SF1">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38688">
        <property type="entry name" value="PYR_REDOX_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="1">
        <location>
            <begin position="9"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL29259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="392" mass="42785" checksum="E7ACAE4196F2E0C2" modified="2015-09-16" version="1">MATRKCAAVVVGAGPAGVAVMGNLLERQLGAITWIDPSFEAGRVHSKYREVPSNTKVSLFQAFAKATQPFQKVIDNTKSPNAFTKLAKLDQESTCTLGFAADMVRGLTDGLMKMEEVYACHGFVKSANLNETTSNWTICIKQNSSEDLETVETTRLILCTGSFPTAAPIPVPGLAIQRLDLDVVLKPTELANTIPSDRPISVAIVGASHSAILAILNLTKLAQTSHPLLRIRWFTRHPLRYAEYKDGWVLRDNTGLKGMAADFARSELEDEKLATSRAGQVLTKIDCAGGQEIESAQYHKYLPACDYLVQAVGYTRASLPELSKNGVPLLMSFDHDSGTFHEPGRSSVIPGLFGAGIAFPERVVDPHGNEEYAVGFWKFMKFLKRVVPSWVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PS93</accession>
    <name>A0A0G4PS93_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid/polyamine transporter I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S032g000017</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793165">
        <property type="protein sequence ID" value="CRL28981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PS93"/>
    <dbReference type="STRING" id="1429867.A0A0G4PS93"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF1">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL28981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="537" mass="58678" checksum="C44099EA45A33AAC" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PSF4</accession>
    <name>A0A0G4PSF4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Ribosome biogenesis protein NOP53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S033g000018</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the NOP53 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793166">
        <property type="protein sequence ID" value="CRL29098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PSF4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PSF4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011687">
        <property type="entry name" value="Nop53/GLTSCR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211">
        <property type="entry name" value="GLIOMA SUPPRESSOR CANDIDATE REGION GENE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211:SF7">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07767">
        <property type="entry name" value="Nop53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017302">
        <property type="entry name" value="Gltscr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="235"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="325"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="281"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="297"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR017302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL29098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="431" mass="49240" checksum="0BC55A77B229366E" modified="2015-09-16" version="1">MSTSVDAPQQFKQTSRKGKKAWRKNVDITAVQEGLRDLKDAEITGGLISEKPSDELFVLDTVGNEDVRKSIAKKQKKPLKSDEILAQRSMIPALDGRKRVNPNVTDGVIEPKTKKPKSDWVSKKEYLRLKQVAKEGNPLGKKTENDFYDPWAEDAEPTLTYDDPRFDFLQKPKPKVEPVTLKHAPISLAANGKPVPSVKMPHAGTSYNPVFEEWDKLLETHGAKAVEAEKLRLEEEAKEAEKQRLIEEAQNDNGEVKSDDESAWEGFESEYEKSEWLNKKRPERKSKTQRNKAIRRKAAEGKAKWEAARIKRDEQAQHILKITEQIQQRELERENQSDADDSEDGDDTALRRKTFGGKKAVPEQPLELVLPDELQDSLRLLKPEGNLLDDRFRTLIVQGKLESRTPITQARKARRQITEKWAAKDFKTGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PSS7</accession>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
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            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL29415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="146" mass="16693" checksum="B3485421E8AA5697" modified="2015-09-16" version="1">MSAGPELDNAAVLEWLEAFHRASATLNADQWLDEFMTDDVEMQYANNPVIKGSEVRQMFKTVLGQLDMMVHDIRYFDYVAPRIYQAATIRYLVKGDSLDTDEITIPGFAVFSVRKDDAGRVKCYRAETFLEPSAVFQRIVEKSNQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PSX4</accession>
    <name>A0A0G4PSX4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PCAMFM013_S036g000069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793169">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL29485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="46" mass="5756" checksum="4D95430696B4E0BC" modified="2015-09-16" version="1">MIYRRIDKDWFMDVFERLRDIKEDYTTEEEEERSIDSSSDSDDLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PT02</accession>
    <name>A0A0G4PT02_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CRL29599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="176" mass="20228" checksum="31B9672AFC074767" modified="2015-09-16" version="1">MHESTKGTEPDNGVSTRDSAPIRLHTVRILFSHDITQLMKDIKRNGLDDVVVDAIPLQELGAQHQAQDDHGNTKNAFLVDLAVDESGIVRVLRKYGIINFIPLSGDDPIVLQQPAMDPDVKKALCYQHLHSKYLQEYGKKRDLAEVLGYEMHKYLKDWYDDRLRDITRRLEQLGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PT89</accession>
    <name>A0A0G4PT89_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S035g000018</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793168">
        <property type="protein sequence ID" value="CRL29323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PT89"/>
    <dbReference type="STRING" id="1429867.A0A0G4PT89"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
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        <property type="match status" value="6"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="369"/>
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        </location>
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        <location>
            <begin position="402"/>
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        </location>
    </feature>
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        </location>
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        </location>
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        <location>
            <begin position="501"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="534"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL29323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="607" mass="66153" checksum="B7D903049AF18EDA" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PT90</accession>
    <name>A0A0G4PT90_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sporulation protein Zds1, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S039g000039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793172">
        <property type="protein sequence ID" value="CRL29730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PT90"/>
    <dbReference type="STRING" id="1429867.A0A0G4PT90"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040206">
        <property type="entry name" value="Zds1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013941">
        <property type="entry name" value="ZDS1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28089">
        <property type="entry name" value="PROTEIN ZDS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28089:SF1">
        <property type="entry name" value="PROTEIN ZDS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08632">
        <property type="entry name" value="Zds_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01327">
        <property type="entry name" value="Zds_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein Zds1 C-terminal" evidence="2">
        <location>
            <begin position="714"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="772"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="687"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="773"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="793"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="826"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="863"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL29730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="874" mass="96069" checksum="4234B5CB5F3A2882" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PTL8</accession>
    <name>A0A0G4PTL8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial substrate carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S039g000072</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793172">
        <property type="protein sequence ID" value="CRL29763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PTL8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PTL8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000009">
        <property type="entry name" value="Mitochondrial 2-oxoglutarate/malate carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="36"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="137"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="236"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL29763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="329" mass="35253" checksum="3828FDF98BEA1E6C" modified="2015-09-16" version="1">MASTIKDGASTAAVSAQTATKTAIENPPDFLHHPYTRHALPFLNGGLAGMTATAVIQPVDMVKVRLQLAGEGARTGPRPSALGITRDIIASGKVLDLYTGLSAGILRQAVYTTARLGFFETFIKKLNVRAEAAGRKVTFAERAAAGLTAGGIAAMIGNPADLALVRMQSDGLKAPEARANYRSVFDALGRITRTEGLAALWAGASPTVVRAMALNMGQLTFFAEAKQQLKQHTSLSAQNQTFAASGIAGFFASFLSLPFDFIKTRLQKQQKDPKTGLVPYKGLVDCARKVAKEEGWLRFYRGFGTYYVRIAPHAMVTLIVADYLNLLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUG2</accession>
    <name>A0A0G4PUG2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Epoxide hydrolase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S040g000018</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793173">
        <property type="protein sequence ID" value="CRL29792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PUG2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PUG2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="38"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL29792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="409" mass="44105" checksum="78F05089C4E27D4C" modified="2015-09-16" version="1">MALQPLPLPAGITSRHIQTTDLNIHILETGYTPENNKPLIILLHGFPEIAYSWRRVLPKLAAAGFHVVAPDQRGFGRTTGWDTGSYEDVDLGTFSLSSLVRDVVLLVHALGYRSVRCVAGHDCGAVSAAMCALMRPDFFQSVALMSHPFNGAPDLPFNTASADASAGSDMAAVGGAGGAGGAGGAEGSAAAAGIHEALAGLGRKHYKWYYSTKQAGPEMSDLGPEEMHRFLRGYFHLKSGSWPGNQPHPLGKWSAADLIELPGYYIMPLNETMPATVTRDMAHEPSDRLASHSWLPDEELAVYAGEYGRTGFYGGLNWYRVRTAAGGRYTKDFDVFAGKKLEPPCAYVSGKLDWGNYQEPGAIEKMKNGVSCADLRIFRLVDGVGHWTPQESPEEVARAIIDLIGGLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PV44</accession>
    <name>A0A0G4PV44_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S048g000010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793181">
        <property type="protein sequence ID" value="CRL30298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PV44"/>
    <dbReference type="STRING" id="1429867.A0A0G4PV44"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL30298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="137" mass="15658" checksum="8671D7DD5560E2BA" modified="2015-09-16" version="1">MKLPLKSLDLSLKEVDPRDRPIGSRNVQADTGNLWTHTLMNTNSFDSPFPGAFPYYSVSQSPVCGKPFCAAREYLETAKRPEACFQCFASEGLPDKVRFQMFHDPGYVTRHFDAIHLKEELLKCNWCEVGLLHRMAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PV89</accession>
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        <submittedName>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CRL30062.1"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PV89"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:protein dimerization activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
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        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
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    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="11">
        <location>
            <begin position="91"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="753"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="765"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="803"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="851"/>
            <end position="861"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL30062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="861" mass="98975" checksum="0C73D22533FF4755" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PW05</accession>
    <name>A0A0G4PW05_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S057g000003</name>
    </gene>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="HG793190">
        <property type="protein sequence ID" value="CRL30681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PW05"/>
    <dbReference type="STRING" id="1429867.A0A0G4PW05"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45977:SF4">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45977">
        <property type="entry name" value="TARGET OF ERK KINASE MPK-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="187"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CRL30681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="299" mass="33292" checksum="F13AE3AC0C7D5902" modified="2015-09-16" version="1">MSATPSGPTASPAVTAVICAALIIGLCLAAFTRWFCCIRRRSTEGNPAAVHPSFFQLQANQSKLQETLPTVEDLNKYLPMVEYKIWKSQQYEQRMSSPQAATEAQKTLSDPNLSALLPQSPTEDPVHLSKLNADVQGQVKISEEVLIKDRHFESSLTPEALESSCQTTQSALSPDWPVGITVSGDACAICLDIMEDEIKVRGLPCNHAFHVNCVDKWLLWRRACCPVCRFAYVSTPQGVFYVVIATRAITDNKDWFRFKNKEEEEEEEENGGLCSKANKPSIRFFTSLFFVARHKRGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PW43</accession>
    <name>A0A0G4PW43_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S048g000049</name>
        <name evidence="3" type="ORF">PCAMFM013_S082g000016</name>
        <name evidence="4" type="ORF">PCAMFM013_S091g000008</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
            <strain evidence="2">FM013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793181">
        <property type="protein sequence ID" value="CRL30337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG793213">
        <property type="protein sequence ID" value="CRL31169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG793222">
        <property type="protein sequence ID" value="CRL31225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PW43"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL31169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL31225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="37" mass="4142" checksum="03B25D2B84C85F0C" modified="2015-09-16" version="1">MSLQIVAVKRRQAEKPISSIPTPDALPFTPADQRCEF</sequence>
</entry>
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                <person name="Dupont J."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </feature>
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            <begin position="71"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL30532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="244" mass="27663" checksum="614F7A169517F00E" modified="2015-09-16" version="1">MANNHKLSGEQTAYESDEVQLRAAPSCYSVRSTASRSKDERNPLKPVTRSHKYRTSCITKKPGPKHDKAIHRKCLQIMSNIEEEIQKAQEEMDEERRKHCQLREQLEAEKVEENSKLQLALTARDTALAESQQVVREVCELQQQLESTNSALQEQVPWNDIQLVLDQAHGDLVSTTTRFWNTVDALQNKRLACYLPGSGVIHTHWPEQGGVATQGDEIPLNFSEWTVPLLDQQEPSATNQHGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PX82</accession>
    <name>A0A0G4PX82_PENC3</name>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Dupont J."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </feature>
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        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL30985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
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</entry>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <authorList>
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                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="91" mass="10031" checksum="8F2DBE177A00BCC5" modified="2015-09-16" version="1">MAITGYFIDINWVYREVLLRFKPLYGAYIGANMSDNISNNKTLVDSLQQALPPEINIIRTPYLAAGTYADPGHTDSVELNILDASAGKKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PXP9</accession>
    <name>A0A0G4PXP9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
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        <lineage>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793197">
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        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="139" mass="15648" checksum="F4878F704F587F13" modified="2015-09-16" version="1">MCLALCFLRSSHWIVLEQQQRKYPNTPRLLRIIYPSFAALSTLAKVVFALVGTLLLSSAHLGGLFILSVDYLGIAAWYWWSFRQSTLDLAQLRCISFYLSVVALLLLVVAIIGMLSKTWIFALEIELVLALVSSLQLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PXR8</accession>
    <name>A0A0G4PXR8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S065g000011</name>
    </gene>
    <organism evidence="7 8">
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        <lineage>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Dupont J."/>
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                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793198">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PXR8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053230">
        <property type="entry name" value="Trans_reg_galc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="72"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="146"/>
            <end position="188"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
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        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
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        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
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        <location>
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            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL30961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="264" mass="28825" checksum="7132790B63E4FC04" modified="2015-09-16" version="1">MTGHNSTLARTQPWRDPRPRALESSDVSVSSGGSSQPVMKSHAAHPAKDNKVAIPRVSNSAILTSNRRVGQACDGCREQKAKCSGLRPACQRCRESDIRCNYTDKKHSADLRSQIRVYEDLLQELHPQLHPQLATQVEKALGSFSASSQLTLSPGPAEDDQQTTNNPVQPSDHTTDDLNRNTDTKATGFFGRPSEITWLHTLLTESDTHSQIARSLAQGLSRPIEAVAPMSLTRTRAIQVTETTANVGISVSLEVNRLLPLFNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PYM2</accession>
    <name>A0A0G4PYM2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S4Jg000003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793313">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PYM2"/>
    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL31481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="31" mass="3486" checksum="BF3C2B503FF53F53" modified="2015-09-16" version="1">MTRVRISRVSGQWDHKGDQSSKCGEWPPSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PYV4</accession>
    <name>A0A0G4PYV4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Polynucleotidyl transferase, ribonuclease H fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S128g000001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793259">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
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        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF438">
        <property type="entry name" value="REVERSE TRANSCRIPTASE TY1_COPIA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="623"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="530"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="900"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="267"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="531"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL31349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1567" mass="179487" checksum="140A8A107DD8E4A4" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NSM7</accession>
    <name>A0A0G4NSM7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Manganese/iron superoxide dismutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S001g000051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4NSM7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S26, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="2">
        <location>
            <begin position="222"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL17091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="298" mass="33680" checksum="B666D6CDA68734C7" modified="2015-09-16" version="1">MFNRFARPQSALRAASSFSPKPTSAFSRFQTRAIHRMPQLQHDAYYKENGVPEFLSPEAFDFSWTQYQSLLVNKLNLLTQDTVDADAKPGELLVKYSKRPEMASVFNYASMAHNNHFFFNCLSPTATTVPEKFAKDIVDTCSSVESLKLDFLATASSMFGPGFVWLAKNLEREGMMHIFCTYSAGSPYPAAHSRRQPVDMATHTPETPLGNQFAGSMGAHAQNQKSLAPGAVDVQPILCVNTWEHAWMMDYGIAGKDEYLERWWDRINWDVVFDNYNAVGSMKNSRSSINRHRSMSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NSZ5</accession>
    <name>A0A0G4NSZ5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-homologous end-joining factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S001g000200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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    <dbReference type="STRING" id="1429867.A0A0G4NSZ5"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="XLF-like_N"/>
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        <property type="entry name" value="XRCC4-like_N_sf"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32235:SF1">
        <property type="entry name" value="NON-HOMOLOGOUS END-JOINING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="XLF_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="4"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="XLF-like coiled-coil region" evidence="10">
        <location>
            <begin position="123"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="256"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="312"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="339"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="409"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="451"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="553"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="615"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
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            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00044529"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF09302"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF21928"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL17240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="644" mass="70366" checksum="7F0BA64EFAE7AF4A" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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    </dbReference>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
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                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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            <end position="147"/>
        </location>
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            <end position="129"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL17226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="147" mass="16459" checksum="9FA53FDD63474947" modified="2015-09-16" version="1">MVCESQSKTDSRAVTLLFKKHKTTVLLMLQPHEPLNHTKERLLDALQSRKVTEINGDIVPDDSDDIEFGEPVDRADLEKGWKRLKSQNGSGTVMEAGLQNGHPVAFRFHKSTEGQDGGVDMDLDGEDPGWDVVMPTYNDEPEEESRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NU32</accession>
    <name>A0A0G4NU32_PENC3</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S001g000547</name>
    </gene>
    <organism evidence="3 4">
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NU32"/>
    <dbReference type="STRING" id="1429867.A0A0G4NU32"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF1">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="104"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL17587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="336" mass="37687" checksum="00451B4C9042118A" modified="2015-09-16" version="1">MAATESQLPTDPKYDQYDFPTTAPEAQPGHPGHTSPEQDAKVHQLRAELEKLGYTERLDTLTLLRFLRARKFDVEAAKTMFTASEKWRKEFGTDDLARNFDYPEKEEVFKFYPQYYHKTDKDGRPVYIEKLGKIDLNQMYKITTADRMLQNLVSEYEKLADPRLPACSRKAGKLLETCCTVMDLKGVGITSVPSVYGYVKQASDISQNHYPERLGKLYLINAPWGFSTVFGAIKGFLDPVTVSKIHVLGSGYQKELLAQVPAENLPVEFGGSCKCAGGCELSDFGPWKEAEWARPPKWATPKEEAPKAAAEPVVQNEDPGYEKKDVEGQEGVQTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NU65</accession>
    <name>A0A0G4NU65_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S001g000592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NU65"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005194794" evidence="1">
        <location>
            <begin position="17"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL17632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="230" mass="24270" checksum="1853D55C5CCC8A9D" modified="2015-09-16" version="1">MQLAALFCFCISAASAVKHYGLTPTEDVRNIVNHRVQAFSGDVMNLTSLFTTDALHNHDGADFLAAELGIFNKTLADVFPPHTSSSGHNSIQARATVEGQCQGHGKIEDNLSSLQINSICYSLAGAAASPITAIIGVIDSNACVESSSGHSVGLCKTIFMMINTAGTTFTGGMVSTYCPAFLSFFVKCKGADAQAHPVNNKDIDMTAFNTQKDRNCDGPTGGEKCTEVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-11-27" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NUJ9</accession>
    <name>A0A0G4NUJ9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AIG2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S001g000723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gamma-glutamylcyclotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NUJ9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045038">
        <property type="entry name" value="AIG2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31544">
        <property type="entry name" value="AIG2-LIKE PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31544:SF4">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL17763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="181" mass="20960" checksum="98D86A07E23AEA42" modified="2015-09-16" version="1">MSDTRPSLMLRKFLEDNDSADALRQNQTEPDSSPEDGWPRDPFRREYCFFSGTLMDPNTLSQVLKSSERPPPPVMRRARVIGYEIKLWGPYPALLDGEPLHLVDGMVYEILSQTELDRLAAYETDKYQLRPCLIDLLNDDDSVEKTIEGVAFMWDGQQDELREGTFDLKQWKKEKQLGDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NUT7</accession>
    <name>A0A0G4NUT7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sugar/inositol transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S001g000782</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NUT7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000100">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF4">
        <property type="entry name" value="SYMPORT, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
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        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="468"/>
            <end position="485"/>
        </location>
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        <location>
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            <end position="525"/>
        </location>
    </feature>
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        <location>
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            <end position="556"/>
        </location>
    </feature>
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        <location>
            <begin position="116"/>
            <end position="560"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL17822.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="633" mass="70456" checksum="5816476BCA1B7C06" modified="2015-09-16" version="1"> </sequence>
</entry>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Silar P."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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        </source>
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    <sequence length="852" mass="93395" checksum="0EC09E40F9DEEE07" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NV95</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
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                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="39"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL18021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="358" mass="40000" checksum="8F16AB82FBA8A81C" modified="2015-09-16" version="1">MHSLPNTLKSEVDSRWKPAIATVSLGAANLHPIITKLDAAAFNGQQGLELFHDDIAQLAKTLRAHATDSAPRTDRDYEIDATHVIRDLSAERDLQVVALQPFRHYEGLINPERHAERIDELKHWVQLCKILGDSLFILIPSSFLDASEITSDRERIAADLAEAADVAFPVRIAYEALAWGTYINTWEDSWDVIKRANRPNLGICLDTFNIAARVWADPIAATGRLGPSADRDLRESMDRLVREIDPDRVLMVQLADGERVDPQTPFLHAPGLPALLAWSRNARLFPCEEDRGGYLPIREVTDACINGLGYTGWVSMEVFSRSTGEDNPAVPMEHAARASRSWLRVMELLEEKPEKGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NVB9</accession>
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        <submittedName>
            <fullName evidence="8">Calcium/calmodulin-dependent protein kinase II isoform</fullName>
        </submittedName>
    </protein>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4NVB9"/>
    <dbReference type="Proteomes" id="UP000053732">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="59"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL17995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="251" mass="28658" checksum="4AD482AF2E69EE2A" modified="2015-09-16" version="1">MAEILTLPDDVSDFGDFVSNEDEQVDLEYVAEPWHKYDIKETPNVFYPIYLGEVLNGRYLVEHKLGFGGGSTVWMVHDLHNRRDVALKVMSLGDWGENEYRMQDEILKNVQDTSRLVTYIRTFLLPGNQHRVLVFPLMGPCIYPIEQLLEGLENLHKAGIVHRDLNERNCMWGMAPLHNLKSNAKYEALGRPLKQTIPYVDLCKKGELVQPVEVPANLRTGEFFLGDFGLAKKLSDSVTQRGYPPFAILLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NVJ5</accession>
    <name>A0A0G4NVJ5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S001g001035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL18075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NVJ5"/>
    <dbReference type="STRING" id="1429867.A0A0G4NVJ5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL18075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="393" mass="44079" checksum="4FBCF3D02C3687B9" modified="2015-09-16" version="1">MPPVWPTGDSPDITGATVGGLYVRDVSNEDIVDKLSSIDPNTHTLLPRTDSSTEDSSTPRYGQGTVDPHSIKMQGLMALFAIIGLLFVIGGIWFFFWAKNGGFVWRKGDWDDYKSTVLRRKGPDGKTLSNATASTKLGGGSVVGKGYTDDGYSFTEGSYTDTATTVTEEKSRRKKFRETAKEKLLRRNKHEQWEGAEDADVRAYREEKPARIGGMNREADGTYNGSDYDTSAPPTSYQQSEMSQTHDFAYEQPRRQRRDPSGFSFTQGSEDVISQTTEERRVRDPSTRRHNRRRERRSEVAPSAPPSAPSSRTSSPRKQRERRSAPQGHFTEPLDFSSAGSRSEYQYSNVDTEDSGTKSYKHPIPGLTKGYRRDGRSRRRDSLSDSEGETQYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NVU5</accession>
    <name>A0A0G4NVU5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S002g000096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NVU5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL18226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="164" mass="16754" checksum="451625C614A6A0DE" modified="2015-09-16" version="1">MATTTTTGALASSTGCGTSAQYEIPVKDASCGVPNNDKYKGFLSKCAKPAGVTAYDNDCALYAPAVDQSVHELTDCLYKAGVDWKDVWCYGDTNATATATSYPTSTETSTKSSSDKKSSGTSTESAATSTSTSGADASLPQAHTSLKAVVLLSTLFASAVFIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NW88</accession>
    <name>A0A0G4NW88_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S002g000201</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NW88"/>
    <dbReference type="STRING" id="1429867.A0A0G4NW88"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054505">
        <property type="entry name" value="Myb_DNA-bind_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22980">
        <property type="entry name" value="Myb_DNA-bind_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like DNA-binding" evidence="2">
        <location>
            <begin position="11"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL18331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="262" mass="29223" checksum="88AAC8BDB8439B08" modified="2015-09-16" version="1">MGQRNKVLETDTPTAKFLYTIIKQLDLKSVDWNRVASDVEVSNGHAARMRYSRFRQQMEGTTGASKPKRKSKKAKTMEPPPEMQGLFPMAPPLMMPTMESIDSSLPGNPFVKCEPGTEGNPNLQSLMQHSPQFMSETSTEGQYYFPQDFASMQFQLASSIPSRIPSPIPTSSFMNPYQLSTASAGYPYPSASTQSGFDLREFDQLPSFTNYAPTINWEPRPPSHQEGPTVKVEEEQQTEEGIPSTGSQEDQPAVIKVENIQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWP2</accession>
    <name>A0A0G4NWP2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pogo transposase / Cenp-B / PDC2, DNA-binding HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S002g000417</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWP2"/>
    <dbReference type="STRING" id="1429867.A0A0G4NWP2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="46"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL18547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="274" mass="30709" checksum="D59A16A9AE20C714" modified="2015-09-16" version="1">MENQIQLAVKAFHEANKPIIAQLAREFDVPYHRLRARIHGRQSHADRGKATRSLNLIQEKALTSYIQTLNNAQASPTPEMIETAANTILKRAGEDRVVGHNWVYRFIARLPPSLNYINQKPKEKSRVDSDPEVILNPPRQRDLDLAAEGSPLRISTPSPSPDFASSATNSPPDTIGRVKKLNTKLLEDLEEIENLPESVQRHIQRSMDANTLLSQELESLNASLMKSQSHKSAANAPKNMKSLLGTKGNVPSPIRANRMMVKRQDVEAKKLKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NX63</accession>
    <name>A0A0G4NX63_PENC3</name>
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        <submittedName>
            <fullName evidence="5">Src homology-3 domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S002g000394</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="entry name" value="SH3_Bbc1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057402">
        <property type="entry name" value="AIM3_BBC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035552">
        <property type="entry name" value="Mti1_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46026">
        <property type="entry name" value="RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46026:SF1">
        <property type="entry name" value="RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25459">
        <property type="entry name" value="AIM3_BBC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="3"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="53"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
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        <location>
            <begin position="431"/>
            <end position="444"/>
        </location>
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    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="448"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
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        </location>
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        <location>
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        <location>
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        <location>
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        <location>
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        </location>
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        <location>
            <begin position="677"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="725"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="747"/>
            <end position="760"/>
        </location>
    </feature>
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        <location>
            <begin position="784"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="849"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="886"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="906"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL18524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1204" mass="130065" checksum="E0D097E91727B02B" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXQ0</accession>
    <name>A0A0G4NXQ0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S002g000742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NXQ0"/>
    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="39"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL18872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="137" mass="15328" checksum="C9B0E97573AE1D30" modified="2015-09-16" version="1">MLSSTSTSTMPTPSAASIRTARLRVRGYPADYDVYESRVAASNSPSQQVGTGATAGETRVQNPAGWPDDYRRIPPHRPINRHLDQSQRRVYTSLGERAFLTIMFTGLEMNVMANRLWKVTGERLSDNLFTYKLGGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NY55</accession>
    <name>A0A0G4NY55_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">4-hydroxybenzoate polyprenyltransferase, mitochondrial</fullName>
            <shortName evidence="11">4-HB polyprenyltransferase</shortName>
            <ecNumber evidence="11">2.5.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Para-hydroxybenzoate--polyprenyltransferase</fullName>
            <shortName evidence="11">PHB:PPT</shortName>
            <shortName evidence="11">PHB:polyprenyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S002g000883</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an all-trans-polyprenyl diphosphate + 4-hydroxybenzoate = a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:44504"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:9564"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58914"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Mitochondrion inner membrane</location>
            <topology evidence="2 11">Multi-pass membrane protein</topology>
            <orientation evidence="2 11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.39" evidence="11"/>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL19013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4NY55"/>
    <dbReference type="UniPathway" id="UPA00213"/>
    <dbReference type="UniPathway" id="UPA00232"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1780:FF:000001">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000003">
        <property type="entry name" value="4-hydroxybenzoate polyprenyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01635">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006370">
        <property type="entry name" value="HB_polyprenyltransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01474">
        <property type="entry name" value="ubiA_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL19013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="416" mass="44630" checksum="490D683712634CB1" modified="2015-09-16" version="1">MLSTSSRLFRGRLSPYRQKVNLTGLYNGRLSTLAHNAYSSMQLKGSRSLAGASSNALRTQVQVRHNSQLQSPATQPIETDSAEKNPATHYIPPKTGLIASLPSSWIPYAELVRLDKPTGTYYLFFPTLFSTLLAAPMAGAAPLPVLGTAALFFSGALIMRGAGCAINDLWDRNLDPHVERTKFRPIARGALSPKKAVLFTGSQLVAGLGVLLSFPSQCLWYGIPSMPIVVAYPLAKRVTNYPQAVLGLAFSWGAIMGFPALGVDLLANHDAMMAAGALYSSCIAWTVLYDMIYAHMDIKDDVKAGIKSIALRHEHNTKAILSGLAVTQISLLAAAGVAAGCGPVFFVGSCGSAALSLGLMIRKVQLKSVPNCWWWFKNGCLLTGGGISLGLLAEYATQYLDLYNTTEPKRLVTEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NY76</accession>
    <name>A0A0G4NY76_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S002g000876</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL19006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NY76"/>
    <dbReference type="STRING" id="1429867.A0A0G4NY76"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF30">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="245"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="318"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="11"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="328"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL19006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="411" mass="41151" checksum="A5CFD9EF80746540" modified="2015-09-16" version="1">MASPSKGAAVTAASIAAGATDTAAQTSASAAETTSETSAAQPTTSSSSTTSSSTAAPTTTSADPTTTSTTTSSTSSTPAPETTTSTPEPTSTSSTTTSSIPSTTSSTTTAPSTTSSAQETTITSTQGTTVVVITSTQTAANTGASSTISSSATDSAALATSTSAASSGGLSPSGTIAVAVVVPVVSVALIILALLFFWRKRKANKAAEEERRKEVEEYGFNPNNDPTLPGIGGAVLPKDDQSSGYRGWGTTSAGRKASTNLSSGMGGLAMSEGSSPGYHHGATPSEGTVQYSDGTRPDSGEIVEPIGVLGAAPVAANNRNGDIHRGPSNASSAYSAANRSDASEESHMSAVHPSAGYYGENPYYGDINTHGAYGGDDYQPVIRDVQARRNTRIENPGVYPRQGNAGIAQNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-11-27" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYD8</accession>
    <name>A0A0G4NYD8_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S002g000958</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Dispensable for SPC enzymatic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL19088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NYD8"/>
    <dbReference type="STRING" id="1429867.A0A0G4NYD8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009542">
        <property type="entry name" value="Spc1/SPCS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 12 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06645">
        <property type="entry name" value="SPC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL19088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="101" mass="10992" checksum="D475F897EB453626" modified="2015-09-16" version="1">MDELLAPIQDAIEGQIDFHGQRLAELLSTILLVISGIASFVVGYIYKDIHLTLWTGLAGTLFTAFVVVPPWPVYNRSPEKWLGSPSARATPGITVDGVKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZH3</accession>
    <name>A0A0G4NZH3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mpv17/PMP22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S003g000262</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZH3"/>
    <dbReference type="STRING" id="1429867.A0A0G4NZH3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
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    </dbReference>
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            <end position="41"/>
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            <end position="74"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL19471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="252" mass="28341" checksum="E22AA5545FF43B75" modified="2015-09-16" version="1">MICSAKRKVLDGLNKRYIYGRVPLLHTIIFLVEMAVAARLAAKFNTYYAERPVLTTMVTNAVLGGVADTVAQLITAFRTRRPQTSGDDFLSIEIPDIDKHKVPAVGELGYGRGSVPPFDFERLTRFMAYGFFMAPLQFQWFGFLSRAFPLTKKNPTAPAFKRVAFDQLIFAPFGLACFFTYMTIAEGGGRRALTHKFRDVYLPTLKANFVLWPAVQILNFRVIPIQFQIPFVSTIGIAWTAYLSLTNSSEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0C9</accession>
    <name>A0A0G4P0C9_PENC3</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005194929" evidence="1">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL19772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="42" mass="4373" checksum="48C3481F02D6D15D" modified="2015-09-16" version="1">MCTSSFFFGLALVPKTLALMVTPDGKHQAGLCEACGNVEGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P1T0</accession>
    <name>A0A0G4P1T0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycerophosphocholine acyltransferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCAMFM013_S004g000168</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM 013</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPC1 family.</text>
    </comment>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021261">
        <property type="entry name" value="GPCAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201">
        <property type="entry name" value="OS01G0585100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10998">
        <property type="entry name" value="DUF2838"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
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    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
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            <end position="218"/>
        </location>
    </feature>
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            <end position="270"/>
        </location>
    </feature>
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            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
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            <end position="327"/>
        </location>
    </feature>
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            <end position="376"/>
        </location>
    </feature>
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        <location>
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            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="34"/>
            <end position="91"/>
        </location>
    </feature>
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            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
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        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006675"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00019082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL20228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="552" mass="63780" checksum="B8F59575A8C568FB" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P1Y6</accession>
    <name>A0A0G4P1Y6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">argininosuccinate lyase</fullName>
            <ecNumber evidence="4">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S004g000253</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
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            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
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    <dbReference type="EMBL" id="HG793137">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P1Y6"/>
    <dbReference type="STRING" id="1429867.A0A0G4P1Y6"/>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000002">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000001">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000025">
        <property type="entry name" value="Argininosuccinate lyase chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
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        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814:SF1">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="6">
        <location>
            <begin position="15"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Argininosuccinate lyase C-terminal" evidence="7">
        <location>
            <begin position="373"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL20313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="464" mass="51821" checksum="C72D9757A40A9CEE" modified="2015-09-16" version="1">MSNPKGVAENMLWGGRFTQGLDPLMVQYNTSLPYDRVFWKQDIAGSIAFARANTNSGILTQQEFAEIERGFKQIAQEWQTNTFVAKENDEDIHTANERRLGEIIGKDIGGKLHTGRSRNEQIATDMRLWLRDELRLIESHLSDLIKVSIARAENDIAYLMPGYTHLQKAQPVRWSHWILSHATAFASELERLREVIRRVNKSPLGTGALAGNCFNIDREAMAKELGFDGLLYNSMNAVADRDFAMETMQWGSSFMLKISRWAEDLIIYSSLEFGFVRLSDAYSTGSSLMPQKKNADSLELLRGKSGRAFGQMAGLMCTIKGLPTTYNKDLQESVEPMLDHVKTVSDSIQIATGVLSTLTVIPEKMIAALAPEMLATEIADYLVRKGVPFREGHHISGRVVALAENTNVPMDTLSLKQLQEVDARFDADVQACLDYERAVELKDAIGGTSKRAVLEQTAVLKKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2N4</accession>
    <name>A0A0G4P2N4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutathione-dependent formaldehyde-activating, GFA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S004g000521</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4P2N4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF30">
        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G03180)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
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    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL20580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="137" mass="14588" checksum="939B03D03F39BAAD" modified="2015-09-16" version="1">MTFTGSCMCGGITYAVEADTYLAALCHCTDCQKWSGGAFTSNAVVPRTSFKVTKGTPNSYDALGNSGKINKHFFCPTCGSSIYTELEIMPDMTCVKAGTLDGGEANLKGKVDVEFYVKNRPAYLAAVEGAKQEQLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P305</accession>
    <name>A0A0G4P305_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S004g000647</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P305"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL20706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="125" mass="14922" checksum="29AE23DA99137BA3" modified="2015-09-16" version="1">MDINKENARYFALLGACQYQPFPMAEQRPIPTPGDGDLEQLTQLRVRATQRVEYHRRIVDDTSQLLHEAQMIILEFHDPYHPTARDLLWDVEARMEVLLHEFLALWAEEIEDRASEHQIWRRPSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P381</accession>
    <name>A0A0G4P381_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hydantoinase/oxoprolinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S004g000722</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P381"/>
    <dbReference type="STRING" id="1429867.A0A0G4P381"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="4">
        <location>
            <begin position="9"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="2">
        <location>
            <begin position="243"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="3">
        <location>
            <begin position="738"/>
            <end position="1268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL20781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1270" mass="137512" checksum="105D8ADFA70C3793" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3C9</accession>
    <name>A0A0G4P3C9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Flavin-containing monooxygenase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S004g000719</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P3C9"/>
    <dbReference type="STRING" id="1429867.A0A0G4P3C9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Flavin-containing monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL20778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="476" mass="53104" checksum="85FBA178360738D8" modified="2015-09-16" version="1">MQVERVAVIGAGPCGLGVAKYLLAEQKFKTITIFEQRDKPGGVWNYTGDQGVSNASVLSHSKPSQEPQQPVNGTFISPVYDSLETNIPNSMMQFTECPFPTGTALFPTHVVVKDYLHQYAEELKPLIRLQSLILDVVLSKKHQNPEWTVTWRDLKTGGTLVEQFDAVVVANGHHNDPYIPEIPGLAEWNRAYPGSIIHSSSYRRPESFANKKVIVVGHSASGIDIATQIGRVSKHPLLISERTATTTLSPEQAAVAQTLPEISHLSAEGGRVEFVDGHEERDVDHIIFCTGYHFSIPFLSSLQPPLITDGVRPHHLYQHVFYSKEPSLALIGFPQRIVPFPFSQAQGAWVARVLSGRVALPSEAEMERWIEEWTVERGEGHSFNILAFPLDATYMNSLYELSSHATRKDGLENDGQGRRPPFWGDKEKWTRARFPLIKKAAQALGDRRAQVKSLEQLGFDFEKEIAQDAEVGNPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3K0</accession>
    <name>A0A0G4P3K0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S005g000026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL20862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P3K0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL20862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="66" mass="7717" checksum="D7B6F384A244DF7E" modified="2015-09-16" version="1">MQLQKIRGLTDPMKILFQKILQHASRMPVYVLLLVGDFYGKLHKCEQAVECYLVALRKVETKEVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3Y7</accession>
    <name>A0A0G4P3Y7_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SPIN90/Ldb17 leucine-rich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S005g000204</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P3Y7"/>
    <dbReference type="STRING" id="1429867.A0A0G4P3Y7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030125">
        <property type="entry name" value="SPIN90/Ldb17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018556">
        <property type="entry name" value="SPIN90/Ldb17_LRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357:SF1">
        <property type="entry name" value="NCK-INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357">
        <property type="entry name" value="SH3 ADAPTER PROTEIN SPIN90 NCK INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09431">
        <property type="entry name" value="SPIN90_LRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPIN90/Ldb17 leucine-rich" evidence="2">
        <location>
            <begin position="184"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL21040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="736" mass="81611" checksum="41ED8B5CBCAF1D73" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P416</accession>
    <name>A0A0G4P416_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S005g000181</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAUS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P416"/>
    <dbReference type="STRING" id="1429867.A0A0G4P416"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070652">
        <property type="term" value="C:HAUS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026243">
        <property type="entry name" value="HAUS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31570">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31570:SF1">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25762">
        <property type="entry name" value="HAUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL21017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="286" mass="32637" checksum="A872AF6420C8D1F1" modified="2015-09-16" version="1">MDSPLVSPAKARQAAIQAKDWAYVNSWLNRQYAPKPVPKFERNEDTLRVLLTLAAANDAADEEATLQHCAREDAVDAYRSREEFERKDPHEQQKNQLLDEVEMCLDDKGRRDLEDLADSAAALGNTLNPSPGDLGQSIVELTVEEFEAQEQIAKVDTLHRYLQRELVRLQAELEELKTDVAYETPSDTQSLTSEWTRGTKTLAIKVGEYQDRIASLEKVQPRGPTIEELIAEEENVIRMRETVKALQGRVRAFHDLPKDTPGAQAKYKELERELRQLRRQRDSMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P4A5</accession>
    <name>A0A0G4P4A5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methylthioribulose-1-phosphate dehydratase</fullName>
            <shortName evidence="7">MTRu-1-P dehydratase</shortName>
            <ecNumber evidence="7">4.2.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MDE1</name>
        <name evidence="10" type="ORF">PCAMFM013_S005g000335</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-(methylsulfanyl)-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15549"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="ChEBI" id="CHEBI:58828"/>
            <dbReference type="EC" id="4.2.1.109"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the aldolase class II family. MtnB subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.109" evidence="7"/>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P4A5"/>
    <dbReference type="STRING" id="1429867.A0A0G4P4A5"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046570">
        <property type="term" value="F:methylthioribulose 1-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000003">
        <property type="entry name" value="Methylthioribulose-1-phosphate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03116">
        <property type="entry name" value="Salvage_MtnB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017714">
        <property type="entry name" value="MethylthioRu-1-P_deHdtase_MtnB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027514">
        <property type="entry name" value="Salvage_MtnB_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03328">
        <property type="entry name" value="salvage_mtnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640:SF7">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="9">
        <location>
            <begin position="26"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL21171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="242" mass="27105" checksum="F1681F1648E36BFC" modified="2015-09-16" version="1">MCPADQTVTTNNDHLVQSEDPEHPANLIPELCRKFYNWGWVTGTGGGTSIRQGEHIFIAPSGVQKELMQPNNIFVLQWPTPKYPASDRNYIRKPLKLNPSACTPLFLTAFEQGAGCCIHTHSQWAVLVTLLVEREKGPDACFEISNIEQIKGIPRGKGKGMLGFFDTLKIPIIENTAFEEDLTSGLEAAMNKYPDTYAVLVRRHGIYVWGDNTAKAKTQCESLDYIFQLAVEMHKLGLPWVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P4D8</accession>
    <name>A0A0G4P4D8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S005g000375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P4D8"/>
    <dbReference type="STRING" id="1429867.A0A0G4P4D8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL21211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="311" mass="32697" checksum="BB968381BFFD05C1" modified="2015-09-16" version="1">MVPHYTMDPNTGYPAGYPVPTQSPQNQQMPFYPNAVPPYPQSKTPSAQHFGAMPMQPGPGGAMMPSGFQQSSAPMDNFSTPYTQTPIPAPMGQFVPPQGTSGANMPSQVAQTFSQNMASISANNLLGTQPKAPSQMNSPQTGAPPAVPNQAQAQAQAHAQAQFAAREKARVTALLDINSALLQEVVNLQAAGKAGPASNPDTNSPALEQPDASKANQKPTPEYIECMRRLQANLAYLATIADRAKKASGVVPQTPAIMTPPPNLPAVNELYARLNELFSRSTKASTPQRPSPPSMQGNGGPSPGTMTESII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P4L0</accession>
    <name>A0A0G4P4L0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S005g000420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P4L0"/>
    <dbReference type="STRING" id="1429867.A0A0G4P4L0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL21256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="449" mass="50417" checksum="BC71097408A1C8CD" modified="2015-09-16" version="1">MSKLPWEDWKLLPCHREDAVFSKWSLVRDTILKRIDLRLVDRIGCYRVGASYSSRRTHPTILIFGHHAKRPNTIEKSLKVINEILESHDLSDVRVEFIEDRTSGYSDDDEAKETGVFDQRVIQFPSMPGQSLSLEENSESSGTLGGFFELKLPSPQEPKVVAITCFHVLNPTEVGKTATTKARIQRWREEGIQPDDQEASNLKVYHPSPRMIREKTRALKKEVSSIQTPSYILWDELAANDQPLRKGDKMMYEGAKQQMLDCKAFIQGLKDFDPGFGRVWAASGFRVRQALTIDGGRHKKPTSCDWALIEVPDERVSSNTTPDGHVLKRSPVPNNLDNVRLCLWGQKSGYSEGDYYSLQDAAVKHAMIEGKEVSVPTVEHTVIPSDTQSGFFAKPGDSGSLVYTKGSHVVVGLLFAGNVVKPRTSMFTHIHDLIADIKSITGATEIRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P4V1</accession>
    <name>A0A0G4P4V1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S005g000497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P4V1"/>
    <dbReference type="STRING" id="1429867.A0A0G4P4V1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL21333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="508" mass="59228" checksum="AC8A2BD3441C8BB1" modified="2015-09-16" version="1">MMTRLSLLRGNSISLEDALTDDDNILHRLDYPQKQREFWSYLLAHKAEIERVVSFHLRAEHCQVADQVDWLCGSYNVCILVYINLLSEECVLIRIPLPYKVGEENIPGNVDEKLRCEVATYIWIRENCPSVPIPTLYGFAFPNGQTFAEESCMGFYHRWHWRITQTMRSWVGFPKTCPYIGFKDNNVLKTGYIIISFVQNGQMLSNTLADHLLSDKTRRQTLFGDIAQIILSLNRVKLPRIGSLTLDDDGLIELKNRPLTLRLQTFENEGIPTIPRDCTYQSVEPYILDLLQLHDNRIHHQPNAIHNLKDGQEQFAALTMMRGLLPQFISRQYRDGPFVLTLTDLHASNIFVDENWHIPSLIDLEWACSSSIEFQTPPYWLTGRPIDDIEHGEHLDAFQEVMTEFINAFEEQGKSVQTSDYSQAEIMRKSWSRGSFWYFQAVNSPKGLLRVFNEHIQRMFCEEHCTQRVFDRTVSPYWSVGAEEFIQTKVEQEAEYKDRIRKRFGEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P553</accession>
    <name>A0A0G4P553_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S005g000603</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P553"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17476">
        <property type="entry name" value="MFS_Amf1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF1">
        <property type="entry name" value="LOW AFFINITY AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="408"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="55"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL21439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="520" mass="56868" checksum="EDB64DBE94D11A99" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6N5</accession>
    <name>A0A0G4P6N5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="1">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S006g000525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="1"/>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P6N5"/>
    <dbReference type="STRING" id="1429867.A0A0G4P6N5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF45">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE CG8306-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioester reductase (TE)" evidence="2">
        <location>
            <begin position="12"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL21985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="443" mass="50260" checksum="672F80AA2C865048" modified="2015-09-16" version="1">MWEYYEGKSILVTGGSGFLGTAIVHRLLTSTSVSRIYLVCRGGNEKLQSRWREWLPGDTVDKLCDPSRLVVLDGDIHLPSLGLSQSELELIRNNTNIIIHAASAINLGSRLKRVSDSIIEASEMMVNLAFTCKSLHRFVYVSSAYSNTHLYYRSHESDVQINEDIYTLENQYDILDELNEVRKHGTSQAYEAENFPWAYAYAKHLTERLLQHRFNEHASNEQLLIVRPGIIGPSQCLPFPGYIMPMSSPYTMLAAAFALVPSRTIKIASKMEDPDAGVTGDEVPVDVVADRLLCHLALGTSGCIHAVSGVRSRLKLETWRRSLMKLRRIPWGLQPLWVDADWKSTNQHWISRLYAVCGASFAFSEKKTIEMCKKIPEKEQQNLQLFTQIDTSENLLTQTEGIRYAMDQYARKSTIAWIIVWLFYSDFGKIDNTTGSPEQRSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P706</accession>
    <name>A0A0G4P706_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutathione synthetase, prokaryotic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S007g000091</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P706"/>
    <dbReference type="STRING" id="1429867.A0A0G4P706"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23132">
        <property type="entry name" value="D-ALANINE--D-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23132:SF23">
        <property type="entry name" value="D-ALANINE--D-ALANINE LIGASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="5">
        <location>
            <begin position="171"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL22110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="401" mass="44278" checksum="4EEA4567CD0F5332" modified="2015-09-16" version="1">MDKVDRSEKSPPHSETPGGAVMYLHIPSRSIGNIQRSQWNTSSSRPLVAVLFQAIDPPIINGVRKPRKPGGYQDSGADIAYTLRSRGIEVITPQPSPSTTQHEGWCFPDSEEGIYSAVTQGATHLWANTIVFSSHPLQTASCLDSYAPTLRVVGQPPGLVEKFDDKMYLNDKLRQQGSFTLPRSWVVNEGDDLNVLLQSIPNYPVVGKPVRGRGSHGVQVCHTPPELKGHIESLFTESPVVLLEEFLSGEEATITVMPPSLDRAEYWSMPPVARFNHDQGIAPYNGTVAVTANSRVVTKEEMRDQSYEEVMRQCEEVASLIKATAPIRIDVRRFRHGSEFAIFDINMKPNMTGPGRPGREDQASLTAMAAAGCGWDYPTLLQNILHGASTLETFRQYRAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7E4</accession>
    <name>A0A0G4P7E4_PENC3</name>
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        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">PCAMFM013_S007g000198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P7E4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL22217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="64" mass="7390" checksum="8ABCAD3E00C8B844" modified="2015-09-16" version="1">MGLLSKIARKLGFVRGYLVVVRHTHGQTRIIHSIWPPYEISDKLEPLDEVDIEGKVENNLRVHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P805</accession>
    <name>A0A0G4P805_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S007g000375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P805"/>
    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL22394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="71" mass="8462" checksum="4DC73601A5F91AE8" modified="2015-09-16" version="1">MTVSGLQQKVIVKSVNHFRIHNERDVLLRFQSRTSLFRPLLDEIEHPASSFCSFRFVEQKEWLDNVTKIMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P8P1</accession>
    <name>A0A0G4P8P1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ankyrin repeat-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S008g000104</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P8P1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL22675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="61" mass="6639" checksum="0121B26866F72461" modified="2015-09-16" version="1">MPMVSDRARSFGKAIKPHGDSSMVKLLLEYGADPEHEDEDGERPILWAAANGYQPITGGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P9V4</accession>
    <name>A0A0G4P9V4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S009g000032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P9V4"/>
    <dbReference type="STRING" id="1429867.A0A0G4P9V4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL23092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="222" mass="26142" checksum="C3487268A0EEFE38" modified="2015-09-16" version="1">MEEKEKTEMANRRALIQAHGRLKGDKTPEEIRLEESGEIIILQRYRLFEHWDQHKSRPPNISHKLLRLDALNIQYWILAQKWWHCRSLLEDGFQLRAFELWRSHPRWYMHQVLVEDCAGRQGCCARGCGCCRNRMIDPMRKLGVGHCTFACGCCRGFRGFDISEKHRKSLKDEFRKEVGDLVRHRNTRVAIWGLVGEGFDSPFDMIDAPPRYQGFGTKEEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PA09</accession>
    <name>A0A0G4PA09_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Anhydro-N-acetylmuramic acid kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S009g000096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PA09"/>
    <dbReference type="STRING" id="1429867.A0A0G4PA09"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006040">
        <property type="term" value="P:amino sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005338">
        <property type="entry name" value="Anhydro_N_Ac-Mur_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30605">
        <property type="entry name" value="ANHYDRO-N-ACETYLMURAMIC ACID KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30605:SF0">
        <property type="entry name" value="ANHYDRO-N-ACETYLMURAMIC ACID KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03702">
        <property type="entry name" value="AnmK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL23156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="414" mass="45259" checksum="F915B53E0E4D85A6" modified="2015-09-16" version="1">MASNSVNGNGHSLDITVLGLNSGTSMYGEIPLEPVIKKRVMNMILHNKTSPSELSEVNVILGETFASAVHQFCKDYDVDIKSIDVLGSHGQTIWLLSMPEAGETRSALTMAEGTFLASRTGITSVTDFRVSDQAAGRQGAPLIAFFDALVLHHPTKLRACQNIGGIANVCFVLPDSHGGVDACYDFDTGPGNVFIDAVVRHYTNGKREYDQDGEMGARGTVNQELVDDFLTHPYFALEPPKTTGREVFRDTIAHEFIVKAEAKGLKPDDVVATITRVTAQAIVDHYRRYAPKDLEIAEIFMCGGGAYNPNIAAFIQENYPNTRIMMLDEAGIPGGAKEAITFAWQGMEAVVGRSIPVPTRVETRQEYVLGKVSPGKNYRNVLRQGMSFGAGRDHLPPVKEMINYVDGKAFDNKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBW0</accession>
    <name>A0A0G4PBW0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 21">Folylpolyglutamate synthase</fullName>
            <ecNumber evidence="6 21">6.3.2.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19 21">Folylpoly-gamma-glutamate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18 21">Tetrahydrofolylpolyglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">PCAMFM013_S010g000213</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20 21">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10580"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="Rhea" id="RHEA-COMP:14740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </cofactor>
        <text evidence="21">A monovalent cation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 21">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 21">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.17" evidence="6 21"/>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PBW0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PBW0"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.10:FF:000009">
        <property type="entry name" value="Folylpolyglutamate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.20:FF:000009">
        <property type="entry name" value="Folylpolyglutamate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023600">
        <property type="entry name" value="Folylpolyglutamate_synth_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF5">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038895">
        <property type="entry name" value="FPGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 21" id="KW-0436">Ligase</keyword>
    <keyword evidence="15 23" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 23" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 21" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="23">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00030592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00030876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRNR" id="PIRNR038895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CRL23775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="517" mass="56846" checksum="EA77EBB34FFC87CB" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PD80</accession>
    <name>A0A0G4PD80_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S011g000279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PD80"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL24285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="160" mass="17263" checksum="0786DB8E6C5BF3FF" modified="2015-09-16" version="1">MEGDSASPSFTPDKQTTSAKMEAPVPALRYIKAQLIFYALILLFYMQQDPSSQVEKANPRFDRCSGAPAVGKGTRKAREGSESSSSSDPIESLVDPETMAKGGPLIGPAAARELDKRSKKDSGKEEDKGSLNIKIHLDLHAKVKLDLEADLYGDIVIGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PD83</accession>
    <name>A0A0G4PD83_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biogenesis of lysosome-related organelles complex 1 subunit 1</fullName>
        </recommendedName>
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        <name evidence="5" type="ORF">PCAMFM013_S011g000203</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BLOC1S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PD83"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009395">
        <property type="entry name" value="BLOC1S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13073:SF0">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13073">
        <property type="entry name" value="BLOC-1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06320">
        <property type="entry name" value="GCN5L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="123"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL24209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="179" mass="19676" checksum="2B7437E848DF8948" modified="2015-09-16" version="1">MDPTPQPNPISNPTADPANTTDDQQQKEALAAFTATLHSVGTNLEAPLRDRAANIQSNAAALERQEAELAENTQRLARQNQQWVGFADETREGLKEIGDVQNWAEMIERDLLALEDMMDVVENGHGEHGSEDGDDRRGSDMELDGGFENGNVNGQNGHVDVDANGKKVDQSAKGWLKWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDG7</accession>
    <name>A0A0G4PDG7_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COP9 signalosome complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S011g000342</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family. CSN5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PDG7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="COP9 signalosome complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040961">
        <property type="entry name" value="CSN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18323">
        <property type="entry name" value="CSN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="10">
        <location>
            <begin position="51"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL24348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="333" mass="37250" checksum="9F60C910EC1FED21" modified="2015-09-16" version="1">MQAAQQAWELENAISVFDPQRDALYEYDADTEKALNDERPWATDPYYFKHVRISATALLKMVMHARSGGSLEIMGLMQGYILPNTFVVTDAFRLPVEGTETRVNAQDEANEYMVSYLQSCRDAGRMENAVGWYHSHPGYGCWLSGIDVATQQTQQMTGPFVAVVIDPDRTISAGRVEIGAFRTFPSNFTPQKEAHEDDEYQTIPLGKAEDFGAHANQYYSLDVSHFKSTLDTEILSLLWNKYWVATLSQSPLFTSRDFGNKQIMDLSQKVRKAARGMEVTGPRSGGVNAKDQQLDKVVRGGQRIVAEEVKGLLASETKMKLFHGIGNQTPSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDQ9</accession>
    <name>A0A0G4PDQ9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S012g000082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PDQ9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL24473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="81" mass="8558" checksum="145D4A733FED58D6" modified="2015-09-16" version="1">MVPLLQPIFGSALSAITTTNDPSRSSNPLNSWHHAGHFGLPLDVNIITAPSPMGLHIARGILGERPPTPTHLPPISASPMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PE35</accession>
    <name>A0A0G4PE35_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sulphate anion transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S012g000182</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Dupont J."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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    <accession>A0A0G4PEH1</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195620" evidence="3">
        <location>
            <begin position="21"/>
            <end position="261"/>
        </location>
    </feature>
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        <location>
            <begin position="31"/>
            <end position="107"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="228"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL24733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="261" mass="26123" checksum="260EE386D93D6F84" modified="2015-09-16" version="1">MHFSQSLIAVTASLVSLGLAADPLSFTSWPKDPLEAGKPVTLTWTGADPEQPVTILLRTGSSGALQDVKPITTSSKGGSFTWTPDSDVKSGDTYAFQISQKDQTNYTALLKSAGKPAADVPEAKDTTSETDTAASTTEATGTTTGATTGTTTGTTTGTTTGTTDTTSASSTSATGSTTEATQTTMTSTTSKALISSSASASGSPSSSAVASSTESLKATSTEDVNGKEASSTATSETGAASIPQYSVHLVMGIVGLLAYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PFD3</accession>
    <name>A0A0G4PFD3_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha,alpha-trehalase</fullName>
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        <alternativeName>
            <fullName evidence="8">Alpha,alpha-trehalase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Alpha,alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
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        <name evidence="14" type="ORF">PCAMFM013_S013g000255</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
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    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 65 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="3"/>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL25012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PFD3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PFD3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.40:FF:000004">
        <property type="entry name" value="Alpha,alpha-trehalose glucohydrolase TreA/Ath1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000032">
        <property type="entry name" value="Vacuolar acid trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="entry name" value="Glycoside hydrolase, family 65, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="GH65_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005194">
        <property type="entry name" value="Glyco_hydro_65_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005195">
        <property type="entry name" value="Glyco_hydro_65_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005196">
        <property type="entry name" value="Glyco_hydro_65_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11051">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11051:SF8">
        <property type="entry name" value="PROTEIN-GLUCOSYLGALACTOSYLHYDROXYLYSINE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03633">
        <property type="entry name" value="Glyco_hydro_65C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03632">
        <property type="entry name" value="Glyco_hydro_65m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03636">
        <property type="entry name" value="Glyco_hydro_65N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195304" description="alpha,alpha-trehalase" evidence="10">
        <location>
            <begin position="21"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 65 N-terminal" evidence="13">
        <location>
            <begin position="69"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 65 central catalytic" evidence="11">
        <location>
            <begin position="425"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 65 C-terminal" evidence="12">
        <location>
            <begin position="764"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CRL25012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1071" mass="116569" checksum="09634CC3E40BDFAA" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PFF1</accession>
    <name>A0A0G4PFF1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S013g000291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL25048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PFF1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PFF1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436:SF3">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="POLYKETIDE CYCLASE SNOAL-LIKE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL25048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="509" mass="56641" checksum="179E96F7A7D2E7EB" modified="2015-09-16" version="1">MANISISAPGLSSGGFLYNNGNNNARLCVTAETEDFDMEIIKNWQEEGFDVLYLPYNGGGKDYARRLQSVKDGLGVGENYAVIAYGDAADYCLDYYINSINASRLCALVAYYPSLIPDTRSRFPLSLQVLVHLAGETVDVLVQPVALGLQGKKRRQTRPINAGIGTGERLDLAYPAFTYDNAVPGFAETDLEEYDHLSADLAWTRTLKVLRKGYSRDPDYEQRYEQHVEGKFFSSNVRKAMDGYVQHKTPGVTYTPTISGGIGKKALRHFYEHYFIGKLPPSMRLRLLSRTTGPDRIVDELYVSYEHTQEVPWMLPGVPPTNKRVEIILVSIVSMRAGRLYSEHVYWDQASVLVQVGLLDPKLLPDGVQGVDRLPVVGREAARRILHEDTELEQEDYHNKMIRRARARARRNMNQSSRMSQVGDESGADLKSEAEQSLPDRSRNKGKAVQKTKPASLQRTATEAGEHEDDDGADTETESSVKGRSEAGNQAAYVEDGGDDSAENGSKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PFY4</accession>
    <name>A0A0G4PFY4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S014g000112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PFY4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055560">
        <property type="entry name" value="DUF7136"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23584">
        <property type="entry name" value="DUF7136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195311" evidence="1">
        <location>
            <begin position="19"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7136" evidence="2">
        <location>
            <begin position="21"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL25216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="263" mass="28821" checksum="4F037384B73D1997" modified="2015-09-16" version="1">MYFLALLLALSQIRCCWAIDTRILEVDLILPRNDTYPPSPIFPIIFAVQNPSLAKSFQPMITLQVEQVDGNFSTIDTFKLWESSNDTSSTRFLNWGTSKFDFEGNFRFTWDLSMDRCSLDKETDEVNFGRFSEFQSLYFTTKNGTSPADFVAATDDDTCDKALAQAINYADLSKLPATESTYGPSCLAEPTTLPKPTNPCNAKINSSAAASMSAAMTSIACARDRPGVTCPTPSSRSAASKAHLKMGGAWILVTASLLTYCLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PFZ7</accession>
    <name>A0A0G4PFZ7_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Polyadenylation factor subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S014g000127</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PFZ7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PFZ7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
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        <property type="match status" value="6"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="179"/>
            <end position="220"/>
        </location>
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        </location>
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        </location>
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        </location>
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            <end position="408"/>
        </location>
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        </location>
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            <end position="546"/>
        </location>
    </feature>
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        <location>
            <begin position="571"/>
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        </location>
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            <begin position="446"/>
            <end position="458"/>
        </location>
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            <begin position="580"/>
            <end position="592"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00026154"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL25231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="602" mass="66405" checksum="DA2B1966EA321250" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PG59</accession>
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        <submittedName>
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        <name evidence="3" type="ORF">PCAMFM013_S014g000183</name>
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="53"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL25287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="146" mass="16800" checksum="55067D3B273BB20A" modified="2015-09-16" version="1">MVYFIQELEDSIKIALQLYTENPKLKIAKLAREFKVPYQLLPGRIKGAKPLKGHNGHGKSLELEQEQTLIHWIHTLNHANAPPTAEMIQQAALQIIRRHDPRRTLGPNWAYRFIKRLPDDCLVITHNPIEKDRIEAVTPGHLNPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGG4</accession>
    <name>A0A0G4PGG4_PENC3</name>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S014g000231</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;3)- or (1-&gt;4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolyzed is itself substituted at C-3.</text>
            <dbReference type="EC" id="3.2.1.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.6" evidence="4"/>
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        <property type="protein sequence ID" value="CRL25335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PGG4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PGG4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000114">
        <property type="entry name" value="Probable endo-1,3(4)-beta-glucanase NFIA_089530"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0430">Lectin</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195318" description="endo-1,3(4)-beta-glucanase" evidence="11">
        <location>
            <begin position="21"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="12">
        <location>
            <begin position="25"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="349"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL25335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="375" mass="40475" checksum="6A5C6B43547A8512" modified="2015-09-16" version="1">MHVLSTILPALGLLAHVSSAAYTLRDDYGTSDSFFDRFNFYTDTDPTNGFVKYVDRNTASSNGLINTGNGVYIGVDHANTATKPGRQSIRLESTTTYKHGLVILDLAHMPSSTCGSWPAFWMLGSNWPNNGEIDIIEGVNEQTQNQMALHTSNGCTINNTGFTGTLDTANCYVQAPGQSANSGCSIQSNSTQSYGTGFNNVGGGIYATEWTGSAISIWFFPSYAVPGDISSGNPNPASWGAPTARFAGGCDIDSHFNDLQIVFDITFCGDWAGSVWNSSSCASRAGSCVDYVQNNPTAFQETYWRVRSLKVYQDWTSSVAGTADVDVEVGVEGVEVKAGVAWDPTGLFERPPQKTSMKHRRQHYRHGHGRGHGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGN1</accession>
    <name>A0A0G4PGN1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RabGAP/TBC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S014g000286</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PGN1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PGN1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031030">
        <property type="term" value="P:negative regulation of septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000039">
        <property type="entry name" value="Cell division control protein 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000026">
        <property type="entry name" value="Mitotic check point protein (Bub2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF263">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BUB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="148"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL25390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="443" mass="49016" checksum="3EB98C3FDDDC2CF6" modified="2015-09-16" version="1">MAKPQPSWALGVPGPDTPASPRTMRTLRKIQSHQVLSTSSALIAQTQASRQASSNEADPGSAATPGAATRARAHRRARSNSDAASREAAATPPVTQRRPARKTGSGIGVKRSLLENFLRDGPQNSNPNEGLRELKYLVLSSRVDADGDGMSPYRIYLWLVLLDIPPMPTDDYLALIHRGRSPAYAKIRNDTFRTLATDPLFKRRVTEASLIRLLNAVAWKLHDSRPKPRSRPTSSRRREMELLVNAPPSIAEESPFGGELEKVTNTTTSDSAMYVQGMNVLCAPFLYAARSEVEAFALFHYFVTRECPGYIRGAMDGVHKGLRLVDRCLEIVEPKLAAYLFSKGMHAELYAFPSVLTLCACTPPLPEVLHLWDFLFAYGPHLNILCIVAQLIRMRDLIFESPSPNKILRSFPPLDAKEIIALTVLLVRKIPGDLYAEMISHAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PH68</accession>
    <name>A0A0G4PH68_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Bestrophin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S015g000183</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793148">
        <property type="protein sequence ID" value="CRL25597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PH68"/>
    <dbReference type="STRING" id="1429867.A0A0G4PH68"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF19">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION CHANNEL-FORMING PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="475"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="475"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL25597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="499" mass="55067" checksum="C74BFC8C0B326BE1" modified="2015-09-16" version="1">MTDGHSAPPSDAPAPAAAADCTAAPVPADVRSHAHHHQAAPTHDKEQASSMGRITPRPTFLEHLATSRDSQFQLDRRDSSELDRYFHGPRNMEKHSKWPIMMRMHGSVMPKMIMPLLTVAIWSTAITAFSHLVHNLGINNILLTVLGFVVGLALSFRSSTAYERWADGRKYWAQLIQTSRNLSRTIWVNTGEREGEEGKDDILRKLSAMNLILAFAVSLKHKLRFEPDIAYEDLAGLAGHLDTFARDAHDRMVVNPPPKSIWKSAGEYLGVSFAESNPRKYVKRSKKPLGHLPLEILNHLSAYIDSCVANGTLVSTLHQGQAITMLSTLNEVLTGTERVLDTPLPTAYSIAIAQISWIYILVLPFQLYNALVWITIPASIVAAYIILGLATIGSEIENPFGQDVNDLPLDTYCRQIAVEMDIMTATPRPNVDDFMSRADNLVLFPLSQLGYPDWKERSVEDIRGALRTKMVVSPSSASATSDGSTIVENARPKTTASSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PIF7</accession>
    <name>A0A0G4PIF7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylose isomerase-like, TIM barrel domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S016g000269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793149">
        <property type="protein sequence ID" value="CRL25988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PIF7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PIF7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050312">
        <property type="entry name" value="IolE/XylAMocC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110:SF57">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110">
        <property type="entry name" value="HYDROXYPYRUVATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="1">
        <location>
            <begin position="25"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL25988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="339" mass="38686" checksum="A5609C6C0B8CF265" modified="2015-09-16" version="1">MTYQPAIMSVSLGRAWLHDFDYKMDQASKAGFKGIEIFYEDLDYFAREISKSDTPTSDQLLQAADDIQSICQAHALDIITLQPFLFYEGLKDREQHAKLVEKMKLWLQLAKRLNTDTIQIPANFLPVDQLTDDIDVIVADLRQLADMGAAETPPVRYAYENLCWSTINDTWEKVWDVVKRVDRPNFGICLDTFNIAGRVWADPASPAGKTVNADSDLKESLERMVAEVDITKVFYLQVVDAERMESPLVPGHPFHVEGQPARMSWSRNARAYMYEEDRGVYLPVEDVARTIISGLGYKGWVSMELFSRTMAEEGQNVPDQHAQRGIASWKKLQQRLQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJ82</accession>
    <name>A0A0G4PJ82_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S018g000158</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJ82"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJ82"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL26465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="142" mass="15923" checksum="40CAF4BC09CAA338" modified="2015-09-16" version="1">MASRLGLEAVVEILLESQLQNCDARGGIRSRTPLSHAAEAGHENVVKLLLDTRQVDVDSRDSQQRTPLAYAAERGDAMVVQLLLDTGKVDVDFQDITHRTPLSYAKWNGDKKVIQMLELYKNRGRADQDHTTRSSIEDSHVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJB1</accession>
    <name>A0A0G4PJB1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Carnitine O-acetyltransferase, mitochondrial</fullName>
            <ecNumber evidence="16">2.3.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PCAMFM013_S017g000256</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(R)-carnitine + acetyl-CoA = O-acetyl-(R)-carnitine + CoA</text>
            <dbReference type="Rhea" id="RHEA:21136"/>
            <dbReference type="ChEBI" id="CHEBI:16347"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57589"/>
            <dbReference type="EC" id="2.3.1.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.7" evidence="16"/>
    <dbReference type="EMBL" id="HG793150">
        <property type="protein sequence ID" value="CRL26273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJB1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJB1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000007">
        <property type="entry name" value="Carnitine O-acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF103">
        <property type="entry name" value="CARNITINE O-ACETYL-TRANSFERASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 19 21" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="20">
        <location>
            <begin position="63"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="18">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00053195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00066910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00073438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CRL26273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="640" mass="72578" checksum="3A2F0327980D9AB3" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJY9</accession>
    <name>A0A0G4PJY9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATPase, AAA+ type, core</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S019g000162</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJY9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJY9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003119">
        <property type="entry name" value="ABC ATPase, putative (AFU_orthologue AFUA_1G16440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000011">
        <property type="entry name" value="Putative ABC transporter ATP-binding component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF135">
        <property type="entry name" value="ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16440)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="50"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="483"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL26745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="739" mass="82122" checksum="E3B219DB82300DD9" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PK29</accession>
    <name>A0A0G4PK29_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alcohol dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S019g000131</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PK29"/>
    <dbReference type="STRING" id="1429867.A0A0G4PK29"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000002">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="9">
        <location>
            <begin position="16"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL26714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="350" mass="37085" checksum="97CC9C64AF1AE67F" modified="2015-09-16" version="1">MSIPETQWAQVAEKIGGPLVLKQIPVPKPGPDQILVKIRYSGVCHTDYHAMMGHWPIPVKMPLVGGHEGAGVVVAKGDLVSTFEIGDHAGIKWLNGSCSECEFCRQSDTPLCAHAQLSGYTVDGTFQQYAVGKATHASKIPKGVPLDAAAPVLCAGITVYKGLKESGVRPGQTVAIVGAGGGLGSLAQQYAKAMGLRVVAIDGGDEKREMCEQLGTETYVDFTKSKDLVADVKAATPGGLGAHAVILLAVSEKPFQQASEYVRSRGTIVAIGLPPDAFLKAPVINTVVRMITIKGSYVGNQQDGVEALDFFARGLIKAPFKLAPLKDLPKIFELMEQGKIAGRYVLELPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKJ6</accession>
    <name>A0A0G4PKJ6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar calcium ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S020g000081</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793153">
        <property type="protein sequence ID" value="CRL26922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKJ6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PKJ6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000011">
        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000021">
        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00846">
        <property type="entry name" value="caca2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF22">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 10" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="362"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="12">
        <location>
            <begin position="91"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="12">
        <location>
            <begin position="299"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL26922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="449" mass="48652" checksum="182ADCA0E4D9B863" modified="2015-09-16" version="1">MSSGNNGSLNANERTGLLGAHRGSFSGLEPHEHIEHGQHHHHPKDNRVWVHWPMHVVHLTWKTIVRDYVNVLLIFVPLGIISGALDWDPTTVFILNFFAIVPLASLLSFATEELAATLGQALGGLMNATFGNAVELIVSIIALRQNQIRVVQASMLGSILSNILLVLGCCFFVGGLRYREQSFNTTVASTMSSLMAVASASLIIPATLYAAISNHSVAKPDATGEIPDPDRAAQDNILILSHGTSIILLIIYVMYLYFQLGSHSDLFEETNGSDTENVAGTEEEEEEEEERILSPWAAAVVLVIVTILVSICADYLVDAIDPLVKTTGMSKTFIGLVLIPIVGNAAEHVTAVVVAYKDKMDLAIGVAIGSSLQIALFVTPFLVILGWIMGIEMTLHFQTFETVAFFISGLVVTLLIQDGKSNYLEGGMCLGMYVILALAFYVYPDNVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PL14</accession>
    <name>A0A0G4PL14_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S020g000218</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 13">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 13">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="EMBL" id="HG793153">
        <property type="protein sequence ID" value="CRL27059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PL14"/>
    <dbReference type="STRING" id="1429867.A0A0G4PL14"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000004">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="120"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="303"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="339"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL27059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="405" mass="45881" checksum="FD00E9C711F320B3" modified="2015-09-16" version="1">MADQEVDLDSIIDRLLEVRGSRPGKQVQLLESEIRFLCTKAREIFISQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIIDEKIFTMHGGLSPDLNSMEQIRRVMRPTDIPDCGLLCDLLWSDPDKDITGWSENDRGVSFTFGPDVVSRFLQKHDMDLICRAHQVVEDGYEFFSKRQLVTLFSAPNYCGEFDNAGAMMSVDESLLCSFQILKPAEKKQNALMTSSLQPPASPSPRIHENDERPRNPSSAPREVRYSSSTPPIISQSHSSTPPRPPGSLSPSATCDKNTTVTSFPGPCDPLYFRSGVQMLISSLVLDFSLCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMX5</accession>
    <name>A0A0G4PMX5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutathione hydrolase</fullName>
            <ecNumber evidence="3">2.3.2.2</ecNumber>
            <ecNumber evidence="3">3.4.19.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Gamma-glutamyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S023g000167</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Gamma-glutamyltransferase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an N-terminal (5-L-glutamyl)-[peptide] + an alpha-amino acid = 5-L-glutamyl amino acid + an N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Mycotoxin biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="3"/>
    <dbReference type="EC" id="3.4.19.13" evidence="3"/>
    <dbReference type="EMBL" id="HG793156">
        <property type="protein sequence ID" value="CRL27709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PMX5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PMX5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.40:FF:000008">
        <property type="entry name" value="Gamma-glutamyltranspeptidase (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF62">
        <property type="entry name" value="GLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195694" description="Glutathione hydrolase" evidence="4">
        <location>
            <begin position="28"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="413"/>
            <end position="415"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="465"/>
            <end position="466"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU368068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL27709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="585" mass="62482" checksum="12A1DDF3501307E1" modified="2015-09-16" version="1"> </sequence>
</entry>
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    <accession>A0A0G4PND1</accession>
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        <submittedName>
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        </submittedName>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
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        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
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    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:oxo-acid-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
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        <property type="entry name" value="Salicylate_synthase"/>
    </dbReference>
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        <property type="entry name" value="salicyl_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="155"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL27890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="421" mass="46430" checksum="D1E3F5C50B039646" modified="2015-09-16" version="1">MPSQISVTFTSQANILETVVEVLSNHKTDDYYAYERGEHWYIGIGSRSSLVIDSQGQTVTVNSESGQASRSIDGTSITDTAREFTTNNLKSGFRIFGQAGFNYAAHILGQEYTPGNWPLLALLVPRLELVLHRDTIILKGVDEENIRPINTEDKGNYTAAVENALSDISAGDYKKVIPSRIVEIPHKVNMPATLLTGRRSNNPARSFSLNHAGCQATGFSPELVVSVNNRRITTEPLAGTRSSTGSNEEVLKLQEDLLHDPKEIVEHVVSVREAITELQRLCPRDTVKIEDFMSIRTRGSVQHLGSRVTGILSPEKDIWDAFDVVFPSITASGIPKYAALEAIQRLEDQPRELYSGAVIMIKDLNSFEAALVLRTVFQDRNRAWIQAGAGVISQSNPQRELTETCEKLASIAPFVIPDVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNS7</accession>
    <name>A0A0G4PNS7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-lactamase-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S025g000102</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793158">
        <property type="protein sequence ID" value="CRL28044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PNS7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058664">
        <property type="entry name" value="ARB_00930-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051478">
        <property type="entry name" value="Beta-lactamase-like_AB/R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935:SF97">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ARB_00930_C"/>
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    </dbReference>
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        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195831" evidence="1">
        <location>
            <begin position="20"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="105"/>
            <end position="434"/>
        </location>
    </feature>
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        <location>
            <begin position="454"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL28044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="601" mass="64774" checksum="D7DCFEA9B95C081A" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNU9</accession>
    <name>A0A0G4PNU9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Translation initiation factor SUI1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S026g000012</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793159">
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    <dbReference type="STRING" id="1429867.A0A0G4PNU9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="eIF2D_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="eukaryotic translation initiation factor 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA binding protein Ligatin/Tma64, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039757">
        <property type="entry name" value="EIF2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039759">
        <property type="entry name" value="eIF2D_SUI1"/>
    </dbReference>
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        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
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        <property type="entry name" value="PUA_eIF2d-like"/>
    </dbReference>
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        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057429">
        <property type="entry name" value="WH_eIF2D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26292">
        <property type="entry name" value="PUA_elF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25304">
        <property type="entry name" value="WHD_eIF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="2">
        <location>
            <begin position="557"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL28147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="647" mass="70976" checksum="BE9D5E4456EA455E" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNZ2</accession>
    <name>A0A0G4PNZ2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fructose-2,6-bisphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S024g000158</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793157">
        <property type="protein sequence ID" value="CRL27903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PNZ2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PNZ2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF32">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="5">
        <location>
            <begin position="127"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="5">
        <location>
            <begin position="284"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="214"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL27903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="703" mass="78575" checksum="9FF9F189D8AA9481" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PP95</accession>
    <name>A0A0G4PP95_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GroES-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S026g000132</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793159">
        <property type="protein sequence ID" value="CRL28267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PP95"/>
    <dbReference type="STRING" id="1429867.A0A0G4PP95"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.33.40:FF:000002">
        <property type="entry name" value="10 kDa chaperonin, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="entry name" value="GroES chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772:SF0">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00056825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL28267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="103" mass="11231" checksum="B90FE1A677F141BF" modified="2015-09-16" version="1">MSVLRNIKSLAPLLDRVLVQRIKPEAKTASGIFLPEAAVKEQNEAQVLAVGPGLLDRDGKRLPMGVNAGDKVLIPQFGGNAIKVGEEEYTLFRDHDILAKIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPD6</accession>
    <name>A0A0G4PPD6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SEP domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S025g000121</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793158">
        <property type="protein sequence ID" value="CRL28063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PPD6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PPD6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031468">
        <property type="term" value="P:nuclear membrane reassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14348">
        <property type="entry name" value="UBA_p47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01770">
        <property type="entry name" value="UBX_UBXN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000020">
        <property type="entry name" value="NSFL1 (p97) cofactor (p47)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000179">
        <property type="entry name" value="Plant UBX domain-containing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.210:FF:000002">
        <property type="entry name" value="UBX domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.210">
        <property type="entry name" value="SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036241">
        <property type="entry name" value="NSFL1C_SEP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012989">
        <property type="entry name" value="SEP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333:SF20">
        <property type="entry name" value="NSFL1 COFACTOR P47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333">
        <property type="entry name" value="UBX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08059">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00553">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102848">
        <property type="entry name" value="NSFL1 (p97 ATPase) cofactor p47, SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51399">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SEP" evidence="4">
        <location>
            <begin position="207"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="3">
        <location>
            <begin position="322"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="267"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL28063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="403" mass="42579" checksum="11BD015A6AACF2F0" modified="2015-09-16" version="1">MEGNPAEHDEAVSQFCAMTGTQTSEAQEYLAANGWDIEAAVTEFFAEQDEALQDTTTGSEQQLGTEGSSGAAAGGRTLGGSGVPASSSAAASSSSSARRAAPKKKFATLGDFASGGGGGAGDSSDGDDTDEHDFFAGGEKSGLAVQNPDDLKKKILEKARRAQPPPSDAPEPRESHFTGTARTLGGDDAPSQLIENPSAPTQQRAQRVQRTLHFWADGFSVDDGELFRSDDPRNAEILDGIRQGRAPLSIMNVQPGQEVDVELKQHEEKYTKPKPKYKPFSGSGQRLGSPTPSVRSQAPTPSSSTPAPSAQAQEPAKPNVDESQPTVTLQIRLGDGTRLTSRFNTTATIGDVYAFVAAATPDGANRAWVLITTFPSTELKDWNVVLGDMPDFKRGGVVVQKWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PR65</accession>
    <name>A0A0G4PR65_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.122</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S031g000072</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="4"/>
    <dbReference type="EMBL" id="HG793164">
        <property type="protein sequence ID" value="CRL28904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PR65"/>
    <dbReference type="STRING" id="1429867.A0A0G4PR65"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF47">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="14">
        <location>
            <begin position="224"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CRL28904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="501" mass="57294" checksum="428F4E652E7A8F77" modified="2015-09-16" version="1">MRQSFHKDNRIVPLGIMLLTCIFFAYHFALVRGSLDGLRMTAVPNTFVESSQHGNLDFDATPNHAGEALDEPVHNVIISPDSSTKPPAISSSPSHSLQSPNGLTTDDVVLMFKTGATVLWKRVPIHMATTFASHRINFNNVLLYSDYPETIGKWGFIDVLSNSSEQVRKSASFQLYLQQEDYESRQNYAELSNLPGDGSGPFGGWKLDKYKFLPMFQHAGRNKPNARWYIFMEDDSYIFLPNLLRHLDKFNHKDPWYLGGLAWKHGDYFAHGGSGIALSRGAWEKSFGKDSRIVQKFEKFTEEHGCGDHILGHVLQEYGVPFGETTDDDRFRYGFNSEPHWSTWYERKNWCKPVYSWHHTHGKDVAKYYEIEQSWDFEKAPLRYRDIYEALVAPYLRSRAEWWDNGSSQYEIESGVAAGAEPPSSVKSIETWRSAWMSVEACEAACIGWADCVQWASYDDRCKMDSRVSLGSGIPEGDSRRQTSLPWVSGWLPRRIENWSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-11-27" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PR87</accession>
    <name>A0A0G4PR87_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S031g000110</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793164">
        <property type="protein sequence ID" value="CRL28942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PR87"/>
    <dbReference type="STRING" id="1429867.A0A0G4PR87"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="38"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL28942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="372" mass="41156" checksum="823F59C8FE85BDD4" modified="2015-09-16" version="1">MDVRQSTAPLGNVSENRHAAIFGVGIGFIVFDSIIIALRIYVRAFMLRALGTDDILMIIGAILNFGLSITIMIGSKYGVGKHALAISESDAMPMLKCVWVTRVLYTLSMGLVKMSLLWFYLRLDPRKYMRWAVFFVMFFNVGLSLASFVGAVAGCSPPSLFWTDPTSSGCMSLGVQLRFYKVNGILNIVTDILTYLLPVPMLYGLQLTWRKKGAILGIFGLGILSIAAGCVRYDFVTKLTTAKEEYYLLLADSLNWCTIEAYIAIFCGCAPSLSVLIKTYAPSIFGSNAAKYHNSAQSPGTSYLQRRNPLKSNRRRGLGDTTLGSQDAIVTVSNPDQDQDGIVMKTDIQMDVVIRKSTEDMTYKRESYNFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRA9</accession>
    <name>A0A0G4PRA9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fatty acid desaturase, type 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S031g000103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793164">
        <property type="protein sequence ID" value="CRL28935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PRA9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PRA9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03507">
        <property type="entry name" value="Delta12-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="2">
        <location>
            <begin position="71"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL28935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="412" mass="47191" checksum="21EB3EEB9DD9B86B" modified="2015-09-16" version="1">MDPLPDKALADTERLVSVNSAMRSPVIASAPSYIVSFCYLLRDILGVVTLATLAAFILPQITNPYLYTISWCLYGFTQGLFGTGLWVLAHECGHGGFSQSQWLNDIIGWSLHSMLLTPYFSWKSTHRRHHLHANHMERDHHYVPYRRDAYAAKLKVEQSKLEDLAADTPVVTTIRIIIQQIFGWPWYLLFNLTAGPESTHPKSPGRWWQNSHFVPTSSLFSPGDYLPVIISDIGIGLSISALWYLGNLFGSKSIILLYVVPWLWVNHWIVAITYLHHTHPLLSKYEQDSWSFLKGALATVDRDFGWVGRFFFHNIIDFHVIHHLFSQIPFYHAEEATRAIIPLLGPRYYQDKASSFVGGLWQAFTECQWVEPGQGNSTENGELRFQKGPSPAPEYRMRHWKDIASTECKAWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRG1</accession>
    <name>A0A0G4PRG1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Primosome PriB/single-strand DNA-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S029g000117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793162">
        <property type="protein sequence ID" value="CRL28701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PRG1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PRG1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL28701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="143" mass="15817" checksum="EADF9D4E8139F05D" modified="2015-09-16" version="1">MSAFLSSLRPAMRMANVPQTARAFSSSPANSIARLTLTGRLGAEPELHATSSGQEIVRYNIATTHGNRENRQTSWWRVTNFVPEGSQRDFVLGLQKGTVVFVEADAKMVTWEDGDGNSRSTLNVVQRTLEVLKRPDHGSDESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRY6</accession>
    <name>A0A0G4PRY6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mediator of RNA polymerase II transcription subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S033g000120</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Mediator complex subunit 7 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793166">
        <property type="protein sequence ID" value="CRL29200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PRY6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PRY6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009244">
        <property type="entry name" value="Mediatior_Med7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044888">
        <property type="entry name" value="Mediatior_Med7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428:SF11">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05983">
        <property type="entry name" value="Med7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0010">Activator</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="217"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL29200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="257" mass="29341" checksum="DDFA4039552343CF" modified="2015-09-16" version="1">MADESQQRAVNTAFAPPPPLWKHFTRENIDKVEQIKAEASKKEDGRPNKNKQWSAAELRALELPSELRYLVPPDIPEGQYSVFGELQTMSTTLPSLQEQGIEQLYPEPPAAGTEQNSQPSPPLNHAYYLLKISKSLLLNFLEFTGILSVSPEQFESKVEDLRNLFINAHHLLNLYRPHQARESLIMMMEEQLNHSREEMRQMDKVKAEVESVLEQLQAEGSRVSATGPEDDTDQAKALKEKADEHSRLIWDLLDKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PSI1</accession>
    <name>A0A0G4PSI1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S033g000063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CRL29143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PSI1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL29143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="77" mass="8885" checksum="B33BA2C81E4F9AE5" modified="2015-09-16" version="1">MPSPEQIASLKELLERCGFDWAENLEDTSVKAHMATKSPMLAPFSRRTGKMNRFRLTIMCEPQIEGQSWRIPWMLGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PSM3</accession>
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        <submittedName>
            <fullName evidence="4">Tetratricopeptide-like helical</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">PCAMFM013_S033g000066</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793166">
        <property type="protein sequence ID" value="CRL29146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF17">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17109">
        <property type="entry name" value="Goodbye"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Fungal STAND N-terminal Goodbye" evidence="2">
        <location>
            <begin position="13"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="303"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL29146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1404" mass="159188" checksum="7E652F2C4DE20C1F" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PTN9</accession>
    <name>A0A0G4PTN9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S040g000061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793173">
        <property type="protein sequence ID" value="CRL29835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="198"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL29835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="236" mass="26179" checksum="B328704F59BBBEB9" modified="2015-09-16" version="1">MSVMLDNTSARLFQITRTVLQTGCQRLIDDILHNGLSLEDELNGRVGQLHLSLEQLKRAGRMMAIDCSTNELVRVVPIGFFTVLIDHPGQDPMSEFDWACIYTSDTLNMLTGDFMRHRDPADVARNLETQSFLWDLGMPFPVTISHAEDSAPGPYVNALQIPPAASMARMNSRIPVRPRPPPPVDTYLAYNRPIPGPYSPALPPRPVSEPEPLSEPASPTGANPMGFHRNPSMQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PTP6</accession>
    <name>A0A0G4PTP6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BTB/POZ fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S036g000095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PTP6"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00651">
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="292"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL29511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="499" mass="57306" checksum="F676E5F7795C807E" modified="2015-09-16" version="1">MESYKLHKHEEPKNMFLRHFANLFLNPEYSDLTIFCGNEAFPVHKIFVQPVLNQLQNMQKAPGEIPFSSFDPFVMRKALEFIYKGQYAAESPPIDNCTDGRDLNCSVNNPRKRKRLRLPYVAYSGIDWAYFHPSILHLRMYAAASELAFHRLRHHAMQAVIASLGTLFDHDQFAVFIQDLYAEEKYRALRDPAMNVITANLHRFKANGYNLIDDELLGKVPNFRDHLLATLMDRTCHKKLTSGPLNADTICDCSFPGATSHNDHPRVACTIFLNQKIIISSIEKQFLNSSYSDLTLVCGQQVFPAHKAILCSSSGYFLRACRGNFKEASGKIQLNAHDPIFVKNALEFLYKGKYTEVSGDFLHSAKSIPCFHARMFAMADYLDIDDLKTEAIGLIFDTLLENLERHVFVTLVHEIYTESASYAEVREALFEVMFNDLIKSPRWDWDWINDLYHDSEFGRDLLFFWPIKEELVSIGKRYTSDKERIIEPDDGGLGSDLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PTU6</accession>
    <name>A0A0G4PTU6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S040g000002</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PTU6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PTU6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF14">
        <property type="entry name" value="DEHYDROGENASE ARBD, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="13"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL29776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="372" mass="39771" checksum="9A10EAD5EC6785B5" modified="2015-09-16" version="1">MFKPTVARNAIKALNTARPAFEASRPATGFTRPLSYTASLGRKKSDDPAKDPILSATTKAPEGASGEKEGQFARTDESVHIEYPPDSEMPTQPVAQGRGGMHFKRTLAQFSLERKVSVVTGGARGLGLVMGQGLVASGSDLAIIDLNKDEAESAAASLIEQFRKENPGLEEMPNVTAHYADVANPDSVSNAMAEVLANHGQIDNLVTSAGFTENFEAINYPFDRMQKLWGVNVDGTYLFAINVAKHLIERKAPGSIVMIGSMSGAIVNVPQPQAPYNAAKAAVRHLAASLAVEWAGHDIRVNCISPGYMLTALTRKILDENPQLRDQWTSLIPAGKMGTPEDLMGAVTFLLSDASKYITGADLRVDGGYTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PU14</accession>
    <name>A0A0G4PU14_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S038g000061</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793171">
        <property type="protein sequence ID" value="CRL29658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PU14"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF240">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="159"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="394"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="1"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL29658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="424" mass="45135" checksum="E86817B2956FC9F5" modified="2015-09-16" version="1">MLSTQEALDITPASDSLEPPKDNNYPEGGLQAWSVVLGAWCAMVPSMGLLNSLGILHAWTSTHQLRDYSESSIGWIFGAYGFFLYLAGAQAGPIFDTFGPNYVIVPGSIGMVVSLVCFSFSEEYYQIFLSFSVLGGLSACTLFTPAVSAVGHWFNIRRGWATGVACTAGGIGGVAFPLIIIFAAPKIGFGWAIRIIALLCAVLCIFACILLKTRLPPNKKAGASVDFHALKDIKYASTTVAIFMVEFAVFIPITYIASYGAYVGVEDTMSYLLIPFLNIGAIPGRFLPGLIADRVGRFNVMVLTSLICSILTLVLWLKAGNNLAAIICYAVLFGFWSGAAISLTPVCISQVCATEDYGKRNGTTFTIVSIGTLVGIPIAGAIQERSGGEYGGLIVFGGVLYLSATVAFILARGICVGWSLKTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PU63</accession>
    <name>A0A0G4PU63_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S039g000011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793172">
        <property type="protein sequence ID" value="CRL29702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PU63"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL29702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="268" mass="30639" checksum="362E6EC0F0636D10" modified="2015-09-16" version="1">MKPHRAHRFLRKVLEFFHLSAPSSKRAVKARNNAKLWCAATTTPPLHSICAARGCDQADVDGQVDDPPEYTIGGVAVEKPSSTRSQLERRIVKLWKKVWLGLYQIDDNEDRYHVERLEALSLGAGLTRTYRVGELQVLRRHFLRSETNNGIASLKLFQGLSLSTLLSVIHILEAYESEIENMKLLYAILRSGQLALHETADLAQTAVVRTEYMAIAEPMEKRIRQYDIRMNVVNMDICDEAMGFYQRQKGEYMYHKAFPNAWSDTISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUH6</accession>
    <name>A0A0G4PUH6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S040g000045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793173">
        <property type="protein sequence ID" value="CRL29819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PUH6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PUH6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL29819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="76" mass="8731" checksum="2392D769DAAB28C1" modified="2015-09-16" version="1">MLTTEPLTSTDDKILVQMGSVREGQTEEEKETYLAGLKEIINDLRRDKVKDFNTVASEIAAYRRRFLQDPSRVLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PV16</accession>
    <name>A0A0G4PV16_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BSD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S045g000057</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793178">
        <property type="protein sequence ID" value="CRL30191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PV16"/>
    <dbReference type="STRING" id="1429867.A0A0G4PV16"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3970.10">
        <property type="entry name" value="BSD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051494">
        <property type="entry name" value="BSD_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019:SF5">
        <property type="entry name" value="BSD DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019">
        <property type="entry name" value="SYNAPSE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BSD" evidence="3">
        <location>
            <begin position="243"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="303"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL30191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="400" mass="43995" checksum="B3C4BC7870BB9EF9" modified="2015-09-16" version="1">MDFAYDHIQEEAFSNKEGAPSDSKPQESNANLNDELQETFRAFSASPWGSRIGGLWDNVRKQGETYYEGARQEYAAASEEAVKGFSDLKETLADRTKGLSLSTAALTGSGEGQSDETATPKAAAEGGESADKGEGEGAGASGESFITRLKAEAARRLKEIEKAEEAADEAILRFGLNIGQKLREAVSILPPDTDESGKLLFESKDAEGKRVIHATRFEAQLHVIHSNLESFSKDPVSDEWPSFKKEFNVEVKTDEIAADLEKYPELRSAMEKLVPEQVEYAEFWTRYYFLRLVVETEEKKRKELLKGANAEDEEEVGWDDDSDSESQSPSTPHVRSGAQTLAPTKETEKAEPRRSNDQHSQADSESSYDVVSGAASRTPGSPKEKAASTAKADESDEDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVF3</accession>
    <name>A0A0G4PVF3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fatty acid hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S052g000027</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793185">
        <property type="protein sequence ID" value="CRL30470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PVF3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PVF3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="5">
        <location>
            <begin position="130"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL30470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="261" mass="29678" checksum="CBD6AC15526C4D5B" modified="2015-09-16" version="1">MDTPKVYLDQVLPQATASWAHIVANYSPQKIEFVGTLLAQVLTFWLPSICYMLLEVVAPSFSQRHKIQPAPKQPTRREIARCFTVVVQNQIISSILHLTLLSAASHAGLNSTYRIETSLPGPVEILRDVFLSLLMREALFYYGHRILHIPTLYIRIHKKHHRFTAPIALAAQFAHPIEHIFANTLPISLPPQLLGSHVVTFWVFLAYELVNTATVHSGYDFFCCKARAHDLHHEKFNLNYGSLGLLDWVHGTDQLKKRRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVQ0</accession>
    <name>A0A0G4PVQ0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S052g000025</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in cell wall morphogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Lipid-anchor</topology>
            <topology evidence="1 10">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="HG793185">
        <property type="protein sequence ID" value="CRL30468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PVQ0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PVQ0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000032">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF5">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 10" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005118207" description="1,3-beta-glucanosyltransferase" evidence="10">
        <location>
            <begin position="24"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="332"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="385"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="390"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="409"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL30468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="459" mass="49079" checksum="B9903218016E1C95" modified="2015-09-16" version="1">MKSSVASMATAITLGASTVLGAATNLKARDSDITPITVKGNAFFKGSDRFYMRGVDYQPGGSSDLSDPIADADGCKRDIKNFKELGLNTIRVYSVDNSKDHDECMTALAEAGIYLVLDVNTPKYSINRAEPEMSYNDVYLQYIFATMEKFAKYDNTLAFFSGNEVINDGPSSKAAPYVKAVTRDMRTYLRSRKLREVPVGYSAADVDTNRLEMAEYMNCGTDDERSDFFAFNDYSWCDPSSFTTSGWDQKVKNFTGYGLPLFLSEYGCNINTRKFQEVKSLYSTEMTPVYSGGLVYEYTEAGNKYGLVKISGDKVTTNKDYDALKTAFEGTKNPTGNGGYNSTGGASGCPKMQKPNWDVDSDSLPAMPAPAKKYLTAGAGKGDGFAGKGSQNSGTKSSGTATQGSGEVAAATGSSSAASGTSSTGAAPSLKPFQFSFAPATVGLVTVLSTVFGASFILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVS0</accession>
    <name>A0A0G4PVS0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L4/L1e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S055g000016</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793188">
        <property type="protein sequence ID" value="CRL30601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PVS0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PVS0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="60S ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025755">
        <property type="entry name" value="Ribos_uL4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013000">
        <property type="entry name" value="Ribosomal_uL4_euk/arc_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045240">
        <property type="entry name" value="Ribosomal_uL4_euk/arch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19431">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14374">
        <property type="entry name" value="Ribos_L4_asso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00939">
        <property type="entry name" value="RIBOSOMAL_L1E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL4 C-terminal" evidence="5">
        <location>
            <begin position="279"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL30601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="370" mass="39934" checksum="BC0EB8EB4BE78805" modified="2015-09-16" version="1">MASRPTVSIATAAGKPSGASHPLPTVFSAPIRPDIVQHVHTGMAKNKRQPYAVSEKAGEQTSAESWGTGRAVARIPRVSGGGTHRAGQAAFGNQCRSGRMFAPTKVWRKWHQKVNVGQRRFATASALAASASPALLFARGHRVANVPEVPLVVESKAVESLNKTKAAIALLQAVGAGADLVKVQKSRKMRAGKGKLRNRRFRQRRGPLVVYNPETDGKDLVKAFRNIPGVETSPVFSLNLLQLAPGGHLGRFVIWTSSAFQALDQVYGTTTSPSALKRDYLLPSNLVANADLTRLINSSEIQSVLKAPKGEARTKRVNVQKKNPLRNKQVMLRLNPYAAAYSKQKLGQQSVEGGKPTAPAESFINTLYEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PW01</accession>
    <name>A0A0G4PW01_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S055g000009</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793188">
        <property type="protein sequence ID" value="CRL30594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PW01"/>
    <dbReference type="STRING" id="1429867.A0A0G4PW01"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056693">
        <property type="entry name" value="DUF7791"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25053">
        <property type="entry name" value="DUF7791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="246"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7791" evidence="3">
        <location>
            <begin position="522"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL30594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="933" mass="106777" checksum="DE3846B1208DEF16" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PW39</accession>
    <name>A0A0G4PW39_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycosyl hydrolase, family 13, subfamily, catalytic domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S050g000026</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793183">
        <property type="protein sequence ID" value="CRL30379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PW39"/>
    <dbReference type="STRING" id="1429867.A0A0G4PW39"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11318">
        <property type="entry name" value="AmyAc_bac_fung_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013776">
        <property type="entry name" value="A-amylase_thermo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006968">
        <property type="entry name" value="PRK09441.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006969">
        <property type="entry name" value="PRK09441.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43447">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001021">
        <property type="entry name" value="Alph-amls_thrmst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="7">
        <location>
            <begin position="67"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL30379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="586" mass="66227" checksum="1D353257112DE7A2" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PWP9</accession>
    <name>A0A0G4PWP9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S062g000031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793195">
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL30892.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
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</entry>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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    </feature>
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            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="CRL30968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="39" mass="4128" checksum="DA3750F880A0D9A9" modified="2015-09-16" version="1">MSSSLSNEHNYISKIVSGPRVASALPSPHSSQTNIQDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
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    <protein>
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    </protein>
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    </gene>
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Dupont J."/>
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                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        </location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="77" mass="8276" checksum="2379253BB862FB9E" modified="2015-09-16" version="1">MFSKSSNSSSKTTSSAASTHSTVSTATTLNSADASTKNHKWYSLGSKSSNSDSKKVDIDLQKKKLHNEALASYFSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PXN6</accession>
    <name>A0A0G4PXN6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hly-III related</fullName>
        </submittedName>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
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                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="ADIPONECTIN RECEPTOR PROTEIN"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
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            <end position="236"/>
        </location>
    </feature>
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        <location>
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            <end position="268"/>
        </location>
    </feature>
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        <location>
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            <end position="308"/>
        </location>
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        <location>
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            <end position="41"/>
        </location>
    </feature>
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        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
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        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
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        </ligand>
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        <location>
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        </location>
        <ligand>
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        </ligand>
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        <ligand>
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        </ligand>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="317" mass="35341" checksum="B7EF74E4A389283E" modified="2015-09-16" version="1">MLQKTARMTRRATSPLEDSQLLTESLPATSKPDDQSYWPTIGSKEQIPGWLRDNDYILEGHPMPTYSYTRSLRLWRCLHMETMNIWTHLLGSVAFVAVGFTLNRSVSLSKDLDFTRGDVFAFGSFLASATICFGLSAGFHTLRSHSYNIHHLWGRMDILGICFLALGAGTSMTYYAFYCRPFIQRVYWGLNLFSAIGAAITLFDTGGGGSKMRTLRGGVFSLLAISAMLPILQSVIELGWTRASNEIGAGWYLAEALSLLTGVSVFVGRFPERLSPGTFDIWGHSHQLWHTFAVLGGAFHVVALVAAYDYRRMHKIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PXV0</accession>
    <name>A0A0G4PXV0_PENC3</name>
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        <submittedName>
            <fullName evidence="8">Catalase-like domain, haem-dependent</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">PCAMFM013_S092g000002</name>
    </gene>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793223">
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    <dbReference type="STRING" id="1429867.A0A0G4PXV0"/>
    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
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    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF26">
        <property type="entry name" value="CATALASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="7">
        <location>
            <begin position="1"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL31227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="373" mass="42622" checksum="3376E2DA1EB871CD" modified="2015-09-16" version="1">MKMHTDEGNLDWVFNNTPVFFIRDPIKFPSVNRSHKRNPRSHLPDPNMFWDFHVGNPEGIHQLLVLFSDRGTPKSVRFLNSYSGHTYKFTKADGSFNYIKIHMKTRQGVKNFTQEEATRVAGEDPDYMIRDMFDAIQRKEFPQWDVFVQVMSPSEAEAYRWNIFDMTKVWPQKDFPLKKIGKMTLNRNAAFSPSTMVPGFAASADPILQARLFAYPDAARYRLGVNYQQLPTNAAKVPVYCPFERDGAMRFDDNYGADPNYVGSTLQPTRFKTEENGVTSQSLSLHTDHEKWVGEVSTYTSQVTDEDFVQPAALWEVLGREQGHQERVIQNLAGNISGVTSSKLRDGVYALFGRVNQELGAKLRKATEAKVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PXZ7</accession>
    <name>A0A0G4PXZ7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S070g000005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793203">
        <property type="protein sequence ID" value="CRL31056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PXZ7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL31056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="146" mass="15793" checksum="22B78A0D599A0355" modified="2015-09-16" version="1">MALGPSKGQGSSPGYDTIIRFTREPPPIIQNGASFTVSVMVIFGESRRLPMALTQAFAINVSLVDEYGARTSGGLQGSLTSNMQFHSYQRARGFAVFDNLTVCQTGSWRLRILLGAFSCAEMTVEARADSNVFHVILHFGGLSQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PY19</accession>
    <name>A0A0G4PY19_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S097g000003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793228">
        <property type="protein sequence ID" value="CRL31256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PY19"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL31256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="118" mass="13549" checksum="D18CD2C2BB624E09" modified="2015-09-16" version="1">MFRDLVDCPNLRDIRRELRSDTVDAFNNVSSLLGGSTEGKSGKPYKSRSSYLEAQRLGVTREEKNRSQKGYSITWMHSLASKKRAWYRNQVHEILAPRDRIVPSGGDKRDSKTAFRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PZ54</accession>
    <name>A0A0G4PZ54_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S3Jg000041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793312">
        <property type="protein sequence ID" value="CRL31430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PZ54"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL31430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="161" mass="17480" checksum="C63FFFC226479E7C" modified="2015-09-16" version="1">MLDVVSKQAYRQGRSPKTRFSWELAGFASAYVPTTTVTPETVPHVQNHTESFARDIITTHPTVGACVGDEMASTQSMKTTQTPSWNNAAMPLALIIPTFTLPTGGTVEAITTAHIPAPTRIGPTLPAEGSGNVVWSSTTRWLTLCYLLLLVVKIIDERRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NT59</accession>
    <name>A0A0G4NT59_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cyclic AMP-dependent chloride channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S001g000198</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NT59"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000041">
        <property type="term" value="P:transition metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18583">
        <property type="entry name" value="ABC_6TM_HMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03253">
        <property type="entry name" value="ABCC_ATM1_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000186">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000050">
        <property type="entry name" value="Vacuolar ABC heavy metal transporter (Hmt1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF651">
        <property type="entry name" value="HEAVY METAL TOLERANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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</entry>
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</entry>
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    </evidence>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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        <location>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL17908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="264" mass="29997" checksum="C664C82373894839" modified="2015-09-16" version="1">MSWPYHFISLSEDDKLHRRELLDLRGYYAQWSIIVVIVAIRIFRFATRSTPKWDGLVSGKTRQYLVCGLWLLWLVGLSIWNSGDDYLHLTKALGRVGLSQLPLQVLMSPAYISRPTASSVLSLLTGIPQSVLTPYHRLFGRVVVSLLLSHAALYTLFFVQSSHPEFGILLFKRVQDLDVQFGLAAIFSAVLLVLFVRPASQKGLQAWLVQGTIQERRKMFYFGHVSLVILLCVMAYSHVQQAQKYMLQTLAASVFNWVCCWAAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NVA9</accession>
    <name>A0A0G4NVA9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="15">1.1.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PCAMFM013_S001g000972</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="15"/>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL18012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NVA9"/>
    <dbReference type="STRING" id="1429867.A0A0G4NVA9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF104">
        <property type="entry name" value="CYTOCHROME B2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="5 17" id="KW-0349">Heme</keyword>
    <keyword evidence="10 17" id="KW-0408">Iron</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="19">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="20">
        <location>
            <begin position="104"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CRL18012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="469" mass="51399" checksum="6002D9AE17A294CA" modified="2015-09-16" version="1">MKLTHQEINRHNNQESCWVAIHGAVYDVTEFLDSHPGGATVILRCAGKDATEDFDSVHSLELLSETLPETALQGYIDPAELDKLRDGPNTTDEKQPKPDDDSPPPLQSLINLHDFEKVAHQRLRATTWAYYSSGADDEISKRNNALAYQKISLRPRILRNIPTVNTTTAILGHSTTLPVYISPVGLAKLAHPEGECALAAAAGKDGLVQVLANGSSMPIEQVMGSRTSPNQPIFQQLYVNKDIQKSIETVRRAERAGASAIWITVDSPVVGKREMDERLNLTVTATDHTGEGKGVAKIMASSISPFIDWEILTWLRQLTDLPVVIKGIQCVEDAVLAYQNGVQGIVLSNHGGRSQDTAQSPLLTLLEIRKFAPHLIESKMQIFIDGGIRRGTDVLKAIALGATAVGLGRPFLFSLSGYGEKGVRRMIEILRQEIEANMVFLGVTSLEELRPEMVNTSRLEKHLIGSVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NW40</accession>
    <name>A0A0G4NW40_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">quinol--cytochrome-c reductase</fullName>
            <ecNumber evidence="3">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PCAMFM013_S002g000186</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16 22">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </cofactor>
        <text evidence="17">Binds 1 heme c group covalently per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="3"/>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NW40"/>
    <dbReference type="STRING" id="1429867.A0A0G4NW40"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000002">
        <property type="entry name" value="Cytochrome c1, heme protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000003">
        <property type="entry name" value="Cytochrome c1, heme protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002326">
        <property type="entry name" value="Cyt_c1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021157">
        <property type="entry name" value="Cyt_c1_TM_anchor_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266">
        <property type="entry name" value="CYTOCHROME C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266:SF3">
        <property type="entry name" value="CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02167">
        <property type="entry name" value="Cytochrom_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00603">
        <property type="entry name" value="CYTOCHROMEC1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81496">
        <property type="entry name" value="Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 17 18" id="KW-0349">Heme</keyword>
    <keyword evidence="13 17 18" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 17 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="19">
        <location>
            <begin position="96"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR602326-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CRL18316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="318" mass="34862" checksum="A52969366773A756" modified="2015-09-16" version="1">MLGRSILRASNRAIARQSLGKSTRASSTAAGAEAASSPFYLTLTAALATAAAAGSTAWYYHLYGQEAFAMTPAEEGLHATQYPWVHERFNKTFDHAALRRGFQVYREVCASCHSLTRVPWRSMVGTMHTVDEMKAFAEEHEYDTEPNNEGNIEKRPGKLSDYIPAPYPNEEAARAANGGALPPDLSLITKGRHGGCNYIFNLLTGYPDEPPAGAAVAEGMNFNPYFPGTGIAMGRVLFDGVVEYEDGTPATTSQMAKDVVEFLNWSAEPEMDERKKMGVKSVALLTGLFAISVWVKRYKWAPLKTRKVVYSPPIGPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWD1</accession>
    <name>A0A0G4NWD1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor, fungi</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S002g000267</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWD1"/>
    <dbReference type="STRING" id="1429867.A0A0G4NWD1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF9">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="250"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL18397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="707" mass="78330" checksum="02B08CC21877742B" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWU7</accession>
    <name>A0A0G4NWU7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S002g000264</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWU7"/>
    <dbReference type="STRING" id="1429867.A0A0G4NWU7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF15">
        <property type="entry name" value="ARYL-ALCOHOL DEHYDROGENASE AAD16-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL18394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="346" mass="38865" checksum="CFDEF1416A9FF820" modified="2015-09-16" version="1">MTSNSKVGYVRLGNSGLKISQIVLGCMTYGDTTWQPWLTEEAEALPLIKHAYDRGINTWDVADTYSNGVSEEILGKALKKYNIPRSRVVIMSKCFHRVDESRGPLDAATHGVNDGDNVNLVGLSRKHIFDAVERSVERLGTYIDVLQIHRLDRDTPMEEIMKALNDVVESGKVRYIGASSMAAWEFQMLQNTAEKHGWHKFISMQGFYNLLYREEEREMFPYCHATGVGLLPWSPLAAGVLAHAWTDRSDKREEQDVFLKLLFRNGEDQASKLIVSRVQEVAAKKGVSMAQVATAWVLSKRGTAPILGLDSVDRIDQAVDAVKVSLTEAEIQYLEEPYVPKQAMPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NX16</accession>
    <name>A0A0G4NX16_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S002g000528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NX16"/>
    <dbReference type="STRING" id="1429867.A0A0G4NX16"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037738">
        <property type="entry name" value="Ecm13-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36826">
        <property type="entry name" value="PROTEIN ECM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36826:SF1">
        <property type="entry name" value="PROTEIN ECM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL18658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="239" mass="26698" checksum="78F474EF3691A363" modified="2015-09-16" version="1">MSITQTYYLAHTARKKLTREASRADHDLRLLVGHANLLDSLMYDLADAEREQERWFNQTVSGATKASSSSSSSSRQHIQWASTVVEEPEEDWDPEDASDLDSELSDSDDSDYDESEFVINTPPVRRRAPSPAAHFQEDLLEEDDEGDDTDSDFEYDDAEDNELSLTRSPSRQSPPELLADSDGESEDEATPPSPPQPTLEAFDEKEPATTAIALAGSDQPHLFEQGYFGTQEQTMIEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXL0</accession>
    <name>A0A0G4NXL0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S002g000686</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NXL0"/>
    <dbReference type="STRING" id="1429867.A0A0G4NXL0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="558"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL18816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="748" mass="82796" checksum="2743E87DBE91D241" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXX6</accession>
    <name>A0A0G4NXX6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Flavohemoprotein</fullName>
            <ecNumber evidence="5">1.14.12.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Flavohemoglobin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Hemoglobin-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Nitric oxide dioxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">PCAMFM013_S002g000694</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">In the presence of oxygen and NADH, it has NADH oxidase activity, which leads to the generation of superoxide and H(2)O(2). Under anaerobic conditions, it also exhibits nitric oxide reductase and FAD reductase activities. However, all these reactions are much lower than NOD activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>2 nitric oxide + NADH + 2 O2 = 2 nitrate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19469"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2 nitric oxide + NADPH + 2 O2 = 2 nitrate + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the globin family. Two-domain flavohemoproteins subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.17" evidence="5"/>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NXX6"/>
    <dbReference type="STRING" id="1429867.A0A0G4NXX6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008941">
        <property type="term" value="F:nitric oxide dioxygenase NAD(P)H activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071500">
        <property type="term" value="P:cellular response to nitrosative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046210">
        <property type="term" value="P:nitric oxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08922">
        <property type="entry name" value="FHb-globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06184">
        <property type="entry name" value="flavohem_like_fad_nad_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.490.10:FF:000003">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000034">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000010">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01252">
        <property type="entry name" value="Hmp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023950">
        <property type="entry name" value="Hmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009805">
        <property type="entry name" value="PRK13289.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396:SF9">
        <property type="entry name" value="NITRIC OXIDE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00410">
        <property type="entry name" value="PHEHYDRXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0216">Detoxification</keyword>
    <keyword evidence="11" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Globin" evidence="22">
        <location>
            <begin position="30"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="23">
        <location>
            <begin position="181"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00030929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00033187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00056398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CRL18824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="433" mass="48091" checksum="EF7F459B853317FB" modified="2015-09-16" version="1">MSARSVFRRPVLQSLAQKFYASAPRRGLTGLTAQQKQIVKSTIPALQEYGVTITTLFYKRLLEKHPELKNVFNTVHQKTGEQPAALAHAVWAYAVNIDHPEALSTAVSRIGHKHASLGVMPAHYPIVGEHLLAAIKDVLGPAANEQVLDAWKAAYQQLADIFIDFEQGLYQQGVKTPGGWKGWRKFYISKKTLESDEIMSFYLTPLDKNTLPSYQPGQFVSVRCYVPELGVYQPRQYSLSDVPNPSHFRISVKREFAKDSKPAGQISNVLHESLPEGSELELSMPFGDFVLDINATTPAVLISGGVGLTPMMSMLKTIINQQGQGRRVVFVHAARNGRVHAMKNDLIQIVAENPSVSRMVFYEDATESDVPGVDYDHIGRVDLTKFKDKAILPDADYYICGPQPFMSAQSKDLEALGVDPKRIHMEVFGSPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYD7</accession>
    <name>A0A0G4NYD7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Brix domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S002g000977</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL19107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NYD7"/>
    <dbReference type="STRING" id="1429867.A0A0G4NYD7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000005">
        <property type="entry name" value="Similar to RNA processing factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF3">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="202"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL19107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="431" mass="49322" checksum="F2DE3A45D460E9C4" modified="2015-09-16" version="1">MVAPGRSGPPPGVMGDIKTGNKLRRKMNHVKRKRAKDAARREERYAFKKEEAKNPKLKEERLRRNIPLTLERKRVWNEADNDTEETGLGLSVDVERIKRAKKEEEDELNRPLEEGEDESEAPESDNESVDSMLESDNSGDEDEDEEKDEDKDASRGRKKTSLRTATERATSPTQSTRSTNLSLAPEALAAKFPTLFTEGPPPTPKILITTGLNSTLHDQAETLTEVFPNSVYIRRNAHRYSHKFSIREISKFAANRNFTTVVVLNEDQKRPSGLTMVHLPVGPTFHFTISNWIEGKRLPGHGRATEHWPELILNNFRTPLGLLTAHLFRTLFPPQPEFEGRQVVTLHNQRDYIFVRRHRYVFREKRETEKAVVGADGKEMLGAEGIRTGLQELGPRFTLKLRRVDKGIQRASGQEWEWKGGMEKTRTLFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYI7</accession>
    <name>A0A0G4NYI7_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA damage-inducible protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S002g001005</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable aspartic protease. May be involved in the regulation of exocytosis. Acts as a linker between the 19S proteasome and polyubiquitinated proteins via UBA domain interactions with ubiquitin for their subsequent degradation. Required for S-phase checkpoint control.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds ubiquitin and polyubiquitinated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DDI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL19135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NYI7"/>
    <dbReference type="STRING" id="1429867.A0A0G4NYI7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05479">
        <property type="entry name" value="RP_DDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01796">
        <property type="entry name" value="Ubl_Ddi1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057273">
        <property type="entry name" value="Ddi1/2_HDD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033882">
        <property type="entry name" value="DDI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019103">
        <property type="entry name" value="Peptidase_aspartic_DDI1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15397:SF3">
        <property type="entry name" value="DNA DAMAGE INDUCIBLE 1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15397">
        <property type="entry name" value="SODIUM-GLUCOSE COTRANSPORTER REGULATORY PROTEIN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09668">
        <property type="entry name" value="Asp_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24669">
        <property type="entry name" value="Ddi2_HDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="14">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="13">
        <location>
            <begin position="396"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="362"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="367"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CRL19135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="434" mass="47580" checksum="5C93309B36740CB3" modified="2015-09-16" version="1">MRITVNVIRPEQADSDIINLEVGGDMSISLLKDIIESDTTIPPEAQQLVYNNQLLQNPTQTLDQAGITEGDMLGVHVTLRAPQPQATRPAASSSVAPRQNTQPRPGMPDPETIRLHILGDPRVREAVRRQNPELSEAADNAQRFREVLLRQQQGEAHREAEKEARIAMLNADPFNHDNQKEIEEIIRQNAVTENLHNAMEHHPESFGRVTMLYIPVEVNGHRLNAFVDSGAQVTIMSPECATSCNIMRLVDRRYGGIAKGVGTAPILGRVHSAQIKIGEMFLPCSFTVMEGKQIDLLLGLDMLRRHQACIDLQRGALVIQDQAVPFLGEGDIPKHLTEEFEAEPTVKGADGAEVGARTGAVTHKAENNPNANATPNNASTSGSQPRINIRPAPTSRWPQDSIARITELGFSRDEAVRALDMAHGDLEGAIGFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYZ4</accession>
    <name>A0A0G4NYZ4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-glucuronidase</fullName>
            <ecNumber evidence="2">3.2.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S003g000062</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.31" evidence="2"/>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NYZ4"/>
    <dbReference type="STRING" id="1429867.A0A0G4NYZ4"/>
    <dbReference type="UniPathway" id="UPA00280"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004566">
        <property type="term" value="F:beta-glucuronidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019391">
        <property type="term" value="P:glucuronoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000027">
        <property type="entry name" value="Beta-glucuronidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001198">
        <property type="entry name" value="Beta-glucuronidase UidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000080">
        <property type="entry name" value="Beta-glucuronidase UidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023232">
        <property type="entry name" value="Glyco_hydro_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023230">
        <property type="entry name" value="Glyco_hydro_2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007538">
        <property type="entry name" value="PRK10150.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10066">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10066:SF67">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00719">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00608">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195259" description="Beta-glucuronidase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolases family 2 sugar binding" evidence="10">
        <location>
            <begin position="52"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="8">
        <location>
            <begin position="222"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 catalytic" evidence="9">
        <location>
            <begin position="316"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL19271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="635" mass="71005" checksum="2583B1353B92DAF4" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0N7</accession>
    <name>A0A0G4P0N7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S003g000630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P0N7"/>
    <dbReference type="STRING" id="1429867.A0A0G4P0N7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052998">
        <property type="entry name" value="Hetero-Diels-Alderase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42060">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42060:SF3">
        <property type="entry name" value="SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195067" evidence="1">
        <location>
            <begin position="23"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL19838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="314" mass="34066" checksum="CD86791F2171BEF1" modified="2015-09-16" version="1">MANLLGSLLLLLLTFIYTPCLAHSPNLREIYRFPNGTWIENIAVRPNGNLLVADLSTAELWEINPSIPSSAHLIHHFDDAEDADGITELSPDIYAVIASNSVYTIDLRSYENTPKSVLIAKVPAGYLNGIAALDEGKAVAITDSQLGLIWRLDIRTGEYSVIHHDETMAANRDMGLLLGVNGLKIVDDHLYYTNSPKRIFCRVRIDTHTGGALGPYEIISHDTRGDDFAIGLHGVGYLAGLIDNVVTRVFPNGSHEVIAGSKDSRDLMTATSAAFGRTQKDRNVLYVTTGGETTLPVNSTSTTGGKVMALSVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0T0</accession>
    <name>A0A0G4P0T0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid transporter, transmembrane</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S003g000681</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P0T0"/>
    <dbReference type="STRING" id="1429867.A0A0G4P0T0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF479">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="54"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL19889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="457" mass="49077" checksum="433142109E2411F9" modified="2015-09-16" version="1">MRSEIVDIPSPIETGPTVQDAESLHGELEKPDLIEQRQDAFGDEANAEIKYKVLKWWQGGLLMVAETISLGILSLPAAIAGIGLVPGLIILIGLGLLSTYTGYVIGQFKWRYPHISSMADAGEVLMGPFGRELFGTGQLLFLIFLMASHILTFTVALNSITGHGTCSIVFGVVGLILSLILSLPRTLEKMSWLSLVSFISILTAVMVTMIALGIQNDGAAVKPIVQANLVTGIMSACNIAFSYVSHNTFFTFMAELKDPKDFPKALALLQSIDMTLYIVAAVVIYRFTGADVASPALGSAGLLISRIAYGIALPTKIVIAGVINGHVAAKSLYVRIFAGTDRMHKRDWVSTGSWVGIAFGLWVIAWVIAEAIPVFNNLLSLITALFGSWFTFGFTGMFWLHMNKGLWFSSPKKIMMTLLNTFAIGVGITLCVLGLYASGSAIHNNPGSASFSCANTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P144</accession>
    <name>A0A0G4P144_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S003g000795</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL20003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P144"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF129">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="54"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="384"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL20003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="446" mass="50385" checksum="D51B96A9E06381F6" modified="2015-09-16" version="1">MDIPKPGEGDVNIGTSTFQACWVLTAIVGVALLFRYAIKVWVRWALPQVTAPGRIWGTEDLFFLVAWGFDITHMICIQMSANWGLGRHFFYLTNEERLNAMKWDFLSQPLAVTSAMVSRAGMMWFLLTCFAASDKKIRLSIIVCSVVQVVVNTVTIVQIIVQCGPNPYQTTDRVQYFHYMWTPLPEDGSVKCQSPAVQTTIGFVQGGFNTVIDFFLAVLAAVELWQFFLRTLHRNPHTSFWSQFCKISGTVRSRRIWQTITLSGPLLLSGCASIVKTYKLKSLGDRQDFTYNIVTFVLWVKIENYSILLASCAPVARLFLRSFVDHRREGRSHGYWSRSRSTGHNEPDTELKRRAQVQDQWLDSATVTSMANADAYIKDEEDQWDGHKHERSSSRISKAEIPEHLDDGRVTVKTDIVVQVDDGRSISSGGTRLLPDGGESHSAGFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P282</accession>
    <name>A0A0G4P282_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S004g000370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P282"/>
    <dbReference type="STRING" id="1429867.A0A0G4P282"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL20430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="107" mass="12781" checksum="D143324DD1D6D4D4" modified="2015-09-16" version="1">MFLVASRCRDSRIRWKAVNLMFHSTLYHGVWRDQYSGLCAQRIVELEEHGLERIGESVYVPRHRRIRKISADIQEEKGQIVMHFVRWPYMPESEILSTLIPLRTENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P288</accession>
    <name>A0A0G4P288_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Anp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S004g000298</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ANP1/MMN9/VAN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P288"/>
    <dbReference type="STRING" id="1429867.A0A0G4P288"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000017">
        <property type="entry name" value="Mannan polymerase II complex ANP1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052086">
        <property type="entry name" value="Mannan_Polymerase_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083:SF6">
        <property type="entry name" value="MANNAN POLYMERASE COMPLEXES SUBUNIT MNN9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083">
        <property type="entry name" value="MANNAN POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03452">
        <property type="entry name" value="Anp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="38"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL20358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="378" mass="41894" checksum="EA689E98C006E7C4" modified="2015-09-16" version="1">MAVARSMRRTSPISLVLAALLAFGFICFMLSPSTPSASSASASSQQRQENAAEHPLSPPTKPFFKSQAVRSDGHKAAPPVVHYDLNSLTNTADSVANGERVLILTPLARFYQGYWDNIEKLSYPHELISLGFIAPKTSEGNAAVAALEKAISKTQSGPIDNRFASISILRQDFDPPLKSQDEKARHAMGAQKERRESMSRARNSLVFTTLGPGTSWVLWLDSDVVETPAALIQDLTAFNQPVIVPNCFQRYYGTSKKQWDIRPYDFNSWVDSQTAQNLAANMGPDEILLEGYAEMPTYRTLMAYLPDMKKLDPKKMLALDGVGGTALLVKADVHRDGAMFPAFPFFHLVETEGFAKMARRLGYEVIGVPDYFVYHYNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2Q7</accession>
    <name>A0A0G4P2Q7_PENC3</name>
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    </gene>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>CDP-N,N-dimethylethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + CMP + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="ChEBI" id="CHEBI:65117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:33776"/>
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    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
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        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
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        <property type="evidence" value="ECO:0007669"/>
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                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
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    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL20737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1543" mass="166193" checksum="7704E9DB702E5B3C" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P379</accession>
    <name>A0A0G4P379_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Negative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S004g000695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P379"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007396">
        <property type="entry name" value="TR_PAI2-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35802">
        <property type="entry name" value="PROTEASE SYNTHASE AND SPORULATION PROTEIN PAI 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35802:SF1">
        <property type="entry name" value="PROTEASE SYNTHASE AND SPORULATION PROTEIN PAI 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04299">
        <property type="entry name" value="FMN_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010372">
        <property type="entry name" value="PaiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL20754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="252" mass="28479" checksum="1653BA0AF3F9585F" modified="2015-09-16" version="1">MFFQSAHEEKDKEVLLHFIRQNPLGVLITGMNSSQQDFLQCTHAPFVVDFPEETGKTDPYLRAHIAKQNPQVKTMMEAVDDKPPNVLELDDDVLVLFNGKHDHYVTPKFYVETKPDTGKVVPTWNYSAVQAYGKMSLYYDSKTPETGEFLAKQLHDLSQHTEKSIMGYTGGEKPEPWEVSEAPQSYTDLLKKNIVGIEIRITKLQGKFKMSQEMRPGDREGVIQGFAKLGGDTGTAISNLVKERGELRDAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P4Z4</accession>
    <name>A0A0G4P4Z4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S005g000539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P4Z4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL21375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="193" mass="22383" checksum="946026FAFC81507B" modified="2015-09-16" version="1">MAKLVPKLKGVSNWKEWEVQVFVILGFNNHVYVQLIRDQIKMPPSPVYEYPSYSSIRALLFKEAKAHSIQIVASNLELQKHHADGEEKWEGANNRPFLQFVSTLGPEALSMNPSHIATYHRVKRFVNLRYKRGDPDIFGMRFKEVLGDYTAFVGYMTAMQELYHFKKGVRANARCRVFILNLTINEEDSDLMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5C7</accession>
    <name>A0A0G4P5C7_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Alpha-galactosidase</fullName>
            <ecNumber evidence="3 7">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S006g000019</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="3 7"/>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P5C7"/>
    <dbReference type="STRING" id="1429867.A0A0G4P5C7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF91">
        <property type="entry name" value="ALPHA-GALACTOSIDASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195054" description="Alpha-galactosidase" evidence="9">
        <location>
            <begin position="25"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL21479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="158" mass="17740" checksum="3C71D91EE8232836" modified="2015-09-16" version="1">MKSLSASWAAWSMAIFPAPPMVFSNWACFKCDLNGTFTEAAMAMLKRGLDIGYDRLTLDDCWMVHDCVEDGSLEWDTDKFPHGIPWLANYMKSNGLHLGIYQDPGLRIRRVGASLGGLRYQQPGYDNDPDFLIAGQPSLSWNKEKDPTLRSGLPSVRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5G0</accession>
    <name>A0A0G4P5G0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Gamma interferon inducible lysosomal thiol reductase GILT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S006g000049</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GILT family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P5G0"/>
    <dbReference type="STRING" id="1429867.A0A0G4P5G0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016671">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004911">
        <property type="entry name" value="Interferon-induced_GILT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234">
        <property type="entry name" value="GAMMA-INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234:SF8">
        <property type="entry name" value="GAMMA-INTERFERON-INDUCIBLE LYSOSOMAL THIOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03227">
        <property type="entry name" value="GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL21509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="312" mass="34490" checksum="CA696E93ACCD3486" modified="2015-09-16" version="1">MEKLPIHSKEGYGDTPQLGNNPDRRARPSTATYLCRIGVIALLFIGYILLLRPSSPGCSGIAPQTENYRAEVQEEYDNYLQPGRFASDAHQTLEQTKIPLEAHIMSKCPDAQDCLQKLVLPAMERISDKVDFKLSFIASVSKDSEEIECKHGPGECIGDMIMLCAANLPFPPTTDEASLPSQYPRTPIIRSLGFANCLINDFARIPDREFVHHCALEHGIDFDALNKCASQQNDDPNDGKDGGPPLSGIALLRESALHGEQLGVKISCTVRLDEVVWCIRDSGEWKNCAQNGQGSQPSALIDQVEKLWKERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5L7</accession>
    <name>A0A0G4P5L7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S006g000140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P5L7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL21600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="149" mass="16774" checksum="E12B799237E93A77" modified="2015-09-16" version="1">MPGHCIQNRILCLAARVSGQERLIACTVLGKRNVAVLPVKSTVFPLFTAARCPTDSPWLYPIDHTIYQSYWADLKIPSEQLFFLALRSRGTDRALRHIHPASLLEIIPRPHGVVFTNLSRPLSIGYRLIELHHERTSTGTIESHNGLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5Y5</accession>
    <name>A0A0G4P5Y5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GTPase-activating protein GYP7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">GAP for YPT7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S006g000271</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P5Y5"/>
    <dbReference type="STRING" id="1429867.A0A0G4P5Y5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000032">
        <property type="entry name" value="GTPase activating protein (Gyp7)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000005">
        <property type="entry name" value="TBC1 domain family member 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF502">
        <property type="entry name" value="SMALL G PROTEIN SIGNALING MODULATOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="5">
        <location>
            <begin position="437"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="734"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="754"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="767"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00072091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00082648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL21731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="812" mass="92845" checksum="A0C0666C5B9F688E" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P684</accession>
    <name>A0A0G4P684_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S006g000339</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P684"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009101">
        <property type="entry name" value="Gurmarin/antifun_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024206">
        <property type="entry name" value="Gurmarin/antimicrobial_peptd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11410">
        <property type="entry name" value="Antifungal_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57048">
        <property type="entry name" value="Gurmarin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0960">Knottin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195282" evidence="4">
        <location>
            <begin position="18"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL21799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="52" mass="5389" checksum="91969C34773FEFBF" modified="2015-09-16" version="1">MRFTILTALAFVGLSIAGSIPSGGQCKQDGSLGNCESKLCVQLANQPFGKCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P799</accession>
    <name>A0A0G4P799_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cofilin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Actin-depolymerizing factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S007g000120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P799"/>
    <dbReference type="STRING" id="1429867.A0A0G4P799"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="6">
        <location>
            <begin position="10"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL22139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="150" mass="16885" checksum="A6B22211A3592716" modified="2015-09-16" version="1">MSVSRSDRSGIPVAEECISAFNQLRSGPEATRPKFIICKISDDKKSIVLEETSTEKDWDFFRMKLCEAADEDGDPAPRYAIYNMKYDIGSEGKQNTTVLIEWSPSCAPLKQLTIPFDLKVSIDADCVMDLEWAVVVQQVREDVRELGMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7F2</accession>
    <name>A0A0G4P7F2_PENC3</name>
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        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S007g000211</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
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                <person name="Lacoste S."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL22230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="136" mass="15864" checksum="6408C39A66CC0BDE" modified="2015-09-16" version="1">MPTIKFYLPRHINNARQAYHWNIITDFNSILIEVDDVNAYIVSTSPWVHDGPITTDVLSSILSRHIGYVPRAFTDFECMVVVYSLLMMDFLPPIDVRMSVNRILYSLNGNDLKRYLTDNLDTEDRDLLESQLQRIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7P5</accession>
    <name>A0A0G4P7P5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fatty acid hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S007g000324</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
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        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:iron ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:lipid biosynthetic process"/>
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    </dbReference>
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        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
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        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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            <end position="80"/>
        </location>
    </feature>
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        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
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        <location>
            <begin position="144"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL22343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="301" mass="35205" checksum="E4981AE8DE4B5BC4" modified="2015-09-16" version="1">MSVSPPGNSTVLPPGTYWGQYQDITKSNTQLSVAERLWVAWYAWMQNDVLATGIMSFVIHELFYFGLSLPWIFINSLGFFKRYKIQSSKVPSLREQWDCAKFVLLSHFTVELPQIWLFHPMAQFCGLSTSIPFPSPWTMTYQIAIFFVMEDTWHYFLHRALHWGPLYKAIHKIHHQYSAPFGLAAEYASPIEVMILGFGTVSCPILWCAFTGNLHILTMYIWIVLRLFQAIDAHSGYEFPWSLHHLLPFWAGADHHDLHHEKFIGNYSSSFRWWDYLLDTEYTPDALKRRRGEKVEAKKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P887</accession>
    <name>A0A0G4P887_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
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                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793140">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P887"/>
    <dbReference type="STRING" id="1429867.A0A0G4P887"/>
    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7708" evidence="1">
        <location>
            <begin position="147"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL22536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="628" mass="71625" checksum="3F2DA14ADBD8791A" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P8G4</accession>
    <name>A0A0G4P8G4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sugar/inositol transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S008g000047</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
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        <property type="protein sequence ID" value="CRL22618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P8G4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF68">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="19"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL22618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="544" mass="61090" checksum="E1173B0DB07E000A" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P997</accession>
    <name>A0A0G4P997_PENC3</name>
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        <submittedName>
            <fullName evidence="9">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S008g000304</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P997"/>
    <dbReference type="STRING" id="1429867.A0A0G4P997"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF57">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="76"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL22875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="638" mass="72260" checksum="28A38277C0018900" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P9P6</accession>
    <name>A0A0G4P9P6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor PRP46</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pre-mRNA-processing protein 46</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S008g000454</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Involved in pre-mRNA splicing and required for cell cycle progression at G2/M.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 8">Belongs to the WD repeat PRL1/PRL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL23025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P9P6"/>
    <dbReference type="STRING" id="1429867.A0A0G4P9P6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000012">
        <property type="entry name" value="Putative pleiotropic regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045241">
        <property type="entry name" value="Prp46/PLRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923:SF0">
        <property type="entry name" value="PLEIOTROPIC REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923">
        <property type="entry name" value="WD40 REPEAT PROTEINPRL1/PRL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="1 7 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="138"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="180"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="222"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="264"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="347"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="62"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU369036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL23025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="451" mass="49378" checksum="E549CCA4E3B486D3" modified="2015-09-16" version="1">MDYTSPQSPDDAVRMSAKRTAELFGAEYLMVTPSTLTDGSIGVSYRRKAEYEDITELPRALAEKQAKATAGRTKRPKIQAQTPADGSGSSMSLVRRPSGTGAGAAAGDGLPKSLVQRPSATQQQRPEWHAPWKLMRVISGHLGWVRALAVEPNNQWFASGAGDRTIKIWNLATGALRLTLTGHISTVRGLAVSPRHPYLFSCGEDKMVKCWDLETNKVIRHYHGHLSGVYTLALHPRLDLLVTGGRDGVCRVWDMRTRSNVHVLGGHKGTVADIKCQDADPQIISGSLDSTVRLWDLAAGKSMGVLTHHKKGVRNLAIHPSEFTFASASTGSIKQWMCPKGDFMQNFDGQNSVINSLAVNDENVLFSGGDDGSMSFWDWKTGHRFQSMETTAQPGSLEAEAGIMASTFDRTGLRLITGEADKTIKIWKQDEEATPETHPLTWAPTLGRQRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PA05</accession>
    <name>A0A0G4PA05_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S009g000088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Penicillium</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL23148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="224" mass="25677" checksum="36D69935A04F6127" modified="2015-09-16" version="1">MAAPREITIESLTGHWVLNKDLTSEADPILKLQKVPWLIRKAFGFATIYIQITQYQTQTPETSQPSTNIDFNQTATAGLAATKEERVLDWKISDHEDYFFGKVQAQSEFVHGVVDEDGIVRPAFELRTDNANAEMRKYLRGEIEADGRKSEGFMLEEWSGMSEEGPGLWVHTFERNVKSGWTAEQIWGFEKFGDSRYFSRRVVVMTTKGQYICGRIVFDFIDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAE7</accession>
    <name>A0A0G4PAE7_PENC3</name>
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        <submittedName>
            <fullName evidence="7">Str. FM013</fullName>
        </submittedName>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <authorList>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
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                <person name="Lacoste S."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PET117 family.</text>
    </comment>
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    <dbReference type="STRING" id="1429867.A0A0G4PAE7"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031568">
        <property type="entry name" value="Pet117"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
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    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
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        </location>
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        </location>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL23291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
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        </source>
    </evidence>
    <sequence length="89" mass="10001" checksum="0654B7B9E85C8A7C" modified="2015-09-16" version="1">MSRASKLTFAATGLGTMGIIGFVHWAQEADRAAMHRGVERDMEKQRVRLERQADFEMQKALEQEYLKLQTVHSTTGDSNTTSQNTSPES</sequence>
</entry>
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    <accession>A0A0G4PAL8</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="CRL23340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="66" mass="7329" checksum="B142C7F35D60EA17" modified="2015-09-16" version="1">MTKEYDLPPPELLKVHAIIARLFHASGAAGRPPAMWSTLCTKQASSSFNTLGSRTTMNRQASRQWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PB96</accession>
    <name>A0A0G4PB96_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="CRL23592.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="66" mass="7303" checksum="10A15A2FACD05D9A" modified="2015-09-16" version="1">MEALTCPLTYVLSEAINGSNAGFSTPHGSNQLHVQHRHFRFALTHVYLKRGTQLDCVYVGQPSDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBN7</accession>
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    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="50" mass="5446" checksum="69E2A07BC1FFF8DF" modified="2015-09-16" version="1">MLGVKVQQVPLHNAVNTPAFSTTSTTTNKPTTANALLSNPIMRYNNLFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCE2</accession>
    <name>A0A0G4PCE2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
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    <organism evidence="1 2">
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Dupont J."/>
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                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF1">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL23977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="246" mass="26145" checksum="265B190DA3762CD4" modified="2015-09-16" version="1">MAPIVVFITGANRGLGQGLVKGFIAKPDHIVIAAVRDPAHSTAQALAELSAGEGSRIIVVKYDASIEQSAFDAVKEASDQGISHLDIVVANAGIAKLYPLVKDVKRADIVEHIDVNVLGAVSLYQATRDLLQKSTGKPIYAIMGSGAGGLARQPPVPSAAYGASKSIVNWYGVRINAEDEWLNAFVLDPGWVQTDMGNAAAQLWGMEEAPDTHEKSITGMVEVLSTGTKEQYGGKFVRFSGEVLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCH9</accession>
    <name>A0A0G4PCH9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S011g000006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PCH9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL24012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="123" mass="13570" checksum="08DB88B5A5545DDC" modified="2015-09-16" version="1">MDSSEYLRILARLDVRAFRAERAQCKLEQSLEAAQTTLKVANEERDHVSKLADIFFDLSQTMGSVIDYLLKDRCSKEPGQEPESTKVMLDVILKQMKTESGISVGDSGSDPEIGSAKAAEKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PD93</accession>
    <name>A0A0G4PD93_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S011g000290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PD93"/>
    <dbReference type="STRING" id="1429867.A0A0G4PD93"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF6">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL24296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="330" mass="36006" checksum="F2FE921CC74371B5" modified="2015-09-16" version="1">MSVHPIHIAVLDTDIPCYPVYAKRGLYSSQFNVLLTAAANRINASEYHKNRRSLSVHVTAFDVVGGSFPHLESLRVSPWSPTENRPPGFPGPVDAILVTGATAAVYDKSHWIPALRSYIARVYADYPTVKIFGSCFGHQLIGQALLASDKSYTSQGSSFKLSVEASSDGHEIGMHPIILNPGFVSNFPPLARFTPEQPFHIQIIHGDAVMSSPEDTLVPHGKGTMMPEPWLNIGSSHKCPIQGLYKPGHVLTLQGHFEFDAFATAELCHKFANQFNWPADLLASHLENIRHSVVPGKDDNDDSKVAAEAVLLFFAGEDWTSSADTNSSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDT1</accession>
    <name>A0A0G4PDT1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S012g000099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PDT1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022190">
        <property type="entry name" value="DUF3716"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12511">
        <property type="entry name" value="DUF3716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL24490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="299" mass="33451" checksum="9C408D5DC3F62733" modified="2015-09-16" version="1">MEYGFIDQLFSLDDNKNVNIQDLENRSRLCQVISALKPVRDVDWSKSRDILSCNMQAIAAHGQRCGDVLAPKDACLSCKAGYGAFKSCVVLSFEGRTRSYIQGGCCMNCYFTRARSYKCSLWGDRMKLKPGKKENDDAGSTVGPSHDPLEYLQAKKRKRTLEYDSTYYQSPLDRPDIKGKGRFGEKRQALESIHSVYDRVVQDMNRLFNSLSKANQLESGEDTEEDEKGPVVVGSDIDEEDTKEIAVEAVVKVEEIEKKDVKIAESGSKKEEEEEKPATSKKSSGGRGKGKKAVDVEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDZ7</accession>
    <name>A0A0G4PDZ7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD-binding, type 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S012g000168</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PDZ7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PDZ7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="108"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL24558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="527" mass="56854" checksum="95885ACB6ECAE496" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PEI2</accession>
    <name>A0A0G4PEI2_PENC3</name>
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        <submittedName>
            <fullName evidence="7">CCAAT-binding factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S012g000342</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CBF/MAK21 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CRL24732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PEI2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027193">
        <property type="entry name" value="Noc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455:SF0">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="6">
        <location>
            <begin position="315"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL24732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="549" mass="62397" checksum="1E2637A2976906DA" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PF57</accession>
    <name>A0A0G4PF57_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S013g000217</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL24974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PF57"/>
    <dbReference type="STRING" id="1429867.A0A0G4PF57"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000266">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="307"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="479"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="75"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="529"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="532"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="553"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="569"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL24974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="606" mass="66352" checksum="5DC2829420139BD7" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PF80</accession>
    <name>A0A0G4PF80_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S013g000200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL24957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PF80"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF8">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL24957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="511" mass="57147" checksum="52B8278BF0885F54" modified="2015-09-16" version="1">METVCGPCWTCRNRRIQCDQSGPPCDKCEKAGMECFDKRPLRWVKGVAIRGKMQGHSYEAMADGTPVKTSKKTQSALSKLNESSRALVQASTGSRTLPVTLQDPSMSNLDQTSKYYIDYYNERICKLFIVYDSPRNPFRSLISFGLNDPVLQKGILALAARHHANTGQPFHQIQAPTSAGLVNANRDALLFKHQAMEALSRVLGDRRTEKSDTTVASIFLLIFLDLLESGSEGWNFHLEGAKSLITLHRPLLEAQAGVNNGPGQTVQQIWGFISSQIHLIETLGATFLRPKLLSEFIFDGQAERNPQEEIEQSFLGCPEFLLSAIQFLSNERDAIAGQLPDGAALQTHIQDTTTMMELIQNFDSYTWASNLQNSRQSFPDEINNLCTLSQAFKIGTLLYGRRILDALTGTTTVQDDLVSELLGLIDMLKDDESLFKCVLWAIFVAGLECRSQAQKNFLVESLEKFWTATSCLNVINAAKILKDYWDQEEGLETPSRWIFDIGRLGRDCLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PFY3</accession>
    <name>A0A0G4PFY3_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="1">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S014g000135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 1">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="1"/>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PFY3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PFY3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF45">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE CG8306-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioester reductase (TE)" evidence="2">
        <location>
            <begin position="12"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL25239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="434" mass="48729" checksum="6A20BF4AC2E5AA3C" modified="2015-09-16" version="1">MWDYYNDKTIFITGGTGFLGTAVVYRLLTQTSASHVYMLCRGGIGKLQSKWTASLSSATVEKLLSTNRIIVMDGDILSPDLGLSQNELNTLQQQVNVIIHSASSINLSKPLDKLSEVITGASERMVDIALTCPNLDRFVYVSTAYSNTYLTPTGEGIEVEIKEDIYDPNPNDHPDVMKEWTQVQENGSSDAYEAHDFPWPYAYAKNLTERLLLDRFTQSGIKDKLLIVRPSIIGPAQDFPSPGYNVPLSSPSTLIAAVVALIPGGMATVATKAVGQISQLFTDEVPVDVVVDRLLAHLAVGTNGCVHAVSGKQARHQFIKWWESAVSLRRVPRNIDLNWKDIDWKSDEQHPLAQFYVIFGSSFEFYEDKTIALSRHPLVETCKELQLFNKLNFGEQLRCRTEDIYSVMNRIAERDERARRVIKRYYQDSIKAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGI3</accession>
    <name>A0A0G4PGI3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S015g000032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793148">
        <property type="protein sequence ID" value="CRL25446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PGI3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PGI3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL25446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="55" mass="6323" checksum="96AFC1CD3A927A1C" modified="2015-09-16" version="1">MIRDLPNELLLQIVSHLNGSAMFASIWRYDIKFQNSNRLHLAIKDDNVDLAADLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PHU7</accession>
    <name>A0A0G4PHU7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S016g000251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793149">
        <property type="protein sequence ID" value="CRL25970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PHU7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PHU7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL25970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="265" mass="30674" checksum="C0B7BA2537509D00" modified="2015-09-16" version="1">MSFLGFSELYIGTEVTFTAPSPQKWVIEEKLTEDVQQMTKWELDGGAGPPFAVFKYLCYSATDSDKKAFMRIYFQIPIAGTEYQPLEVRQRQAAPPRKHRELDVLKDLQLRQCPVVPTLLAYKEDKQGNNGVVPDGYITHIVWDKVPGKSLNQDKVWDSKSVLLREAVRAKFRDIWEYIKPPFYQSRVKLTDLRELRRYGWEPGMPGLENIIYDEVTKVMHIAGFRDPAPLDPEHKFTDMTFVDWGLAIPPSNAGWEKDSTKWAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PII2</accession>
    <name>A0A0G4PII2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S017g000185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793150">
        <property type="protein sequence ID" value="CRL26202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PII2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PII2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL26202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="416" mass="46031" checksum="46F27CFF692FCF3F" modified="2015-09-16" version="1">MSSDDASPQAGQQYNNNSSDDSPRALPGHNPAIAKYNKVQLRPESIVKPDLFTLYFGFFGTAAWTKRVAITINERVENHYVLTERPPTQDEFDALVEHGTQCLYYGRTGIPISSFLGTALLYRQASKSPLFPRDPTPAALFSTLRTMWVDTTLRGNLGSAAFKMLFIMTLGSMASNAYAVSKDAMHMLTDPRLKGFIEDVRKAKPEDVRQRKIQAANERLRSMRSGEQDVGSQIMGTTSEYAGGEEYQQEQPSDSSPQANSYSEYVNSNDTKGNSQSASYESPTSELNAGAIWARGRNTQSESKSALDFMDEDDASPTAAEYRNTNIDGSPTTGSAWDRIRRQNAAPRQPRQQPGLSQPSPNPYASSAEFGQSEQEKYDTTQKTERDLAQAEFDRMIEAERNAGSEGSPRNRGWGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PII3</accession>
    <name>A0A0G4PII3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Snf7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S017g000137</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793150">
        <property type="protein sequence ID" value="CRL26154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PII3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PII3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="18"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL26154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="223" mass="25660" checksum="53B1F8EB482161ED" modified="2015-09-16" version="1">MNIVEWAFGKRMTPAERLRKHQRALDRTQRELDRERVKLENQEKKLVQDIKKSAKNGQVGACKIQAKDLVRTRRYIQKFYQMRTQLQAISLRIQTVRSNEQMMQSMKGATMLLGSMNRQMNLPALQRIAMEFERENDVMDQRQEMMDDAIDEATGMEGEEEEGEDILKEVLDEIGVDLNQALGDTPEHIQKAPVNETRVAQAIGGGGNTSDDDLQARLDSLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJ49</accession>
    <name>A0A0G4PJ49_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonuclease III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S018g000110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJ49"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000018">
        <property type="entry name" value="RNase III domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040030">
        <property type="entry name" value="Ribosomal_mL57"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L15, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="2">
        <location>
            <begin position="98"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL26417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="256" mass="27999" checksum="E3CA1F73E6857E79" modified="2015-09-16" version="1">MAMNLSSRAARTACAASKFAARPIAGVIPSRTFATSTPEESSQQEKPRWSYTPAAAKAPFSLHLDSKRPTFHVNADPQLLDRFYIRLFGNGGDQLLSDETKWLAVTHKSFDQGRRGFNDRLAFLGKRIVQLQASLALAQDVPHAGAAAPAENKDEFGRVPFTHPALDGLNNLSGETKKILTERSKLAELANKYELQKVLRWSPRKPNDLRASGLELVLAHTMYAIVGAVSLEKGGVVATKVARERILEPLGLKSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJ85</accession>
    <name>A0A0G4PJ85_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S018g000087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJ85"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL26394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="62" mass="7067" checksum="657DA6EC58BDF5C0" modified="2015-09-16" version="1">MPVSLLPRRVHRICQRAGPTSRYRPARFYEAHEFFESKSADFAPVQEGEQHISPQALRLSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJ96</accession>
    <name>A0A0G4PJ96_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">penicillopepsin</fullName>
            <ecNumber evidence="5">3.4.23.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S018g000165</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted aspartic endopeptidase that allows assimilation of proteinaceous substrates. The scissile peptide bond is attacked by a nucleophilic water molecule activated by two aspartic residues in the active site. Shows a broad primary substrate specificity. Favors hydrophobic residues at the P1 and P1' positions, but can also activate trypsinogen and hydrolyze the B chain of insulin between positions 'Gly-20' and 'Glu-21'.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1', but also cleaving 20-Gly-|-Glu-21 in the B chain of insulin. Clots milk, and activates trypsinogen.</text>
            <dbReference type="EC" id="3.4.23.20"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.20" evidence="5"/>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJ96"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJ96"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF47">
        <property type="entry name" value="ENDOPEPTIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01220)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195508" description="penicillopepsin" evidence="10">
        <location>
            <begin position="20"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="11">
        <location>
            <begin position="43"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL26472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="400" mass="43153" checksum="283877F0FBDB95C2" modified="2015-09-16" version="1">MLLPYLLTIAAGLLVPAGSINIPTRRTSSATTTLRATQYGTVFDAPVTIGNQSFMLLVDTGSSDTYVMQTGYKCINSTDNLVIPQSDCLYSNKTYHKSKTYRHVNNEMFGVQYGAGLASGHMAYEKVSMNGVTVNAQKIAISNVSNPMGDDVNSGLLGLGYPALTSAHPANHTSNSTYWRDRLVYNPLLFTMHEQGLIDPYFSLALAHTPQNQSTSFGGYLTLGGLPPVNHSSHFSTVPVEITENIPLWYTSGKSVRSYWSATVNNITYGSSSNNLTTNTTSFQAFVDSGNDISYLPPAVVEHINALFSPPATYDSDLGLYVVDCSAKAPEFGLSLGDQTFYHDGSDLIYQIGGGVCVSNLASSAEVSLGDVTLNIISVPFLKNVVAVFDFGKNEMRAMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKE5</accession>
    <name>A0A0G4PKE5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">26S proteasome regulatory subunit RPN2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S020g000029</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the proteasome subunit S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793153">
        <property type="protein sequence ID" value="CRL26870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKE5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PKE5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000017">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016642">
        <property type="entry name" value="26S_Psome_Rpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048570">
        <property type="entry name" value="PSMD1_RPN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040623">
        <property type="entry name" value="RPN2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18004">
        <property type="entry name" value="RPN2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21505">
        <property type="entry name" value="RPN2_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015947">
        <property type="entry name" value="26S_Psome_Rpn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit 1/RPN2 N-terminal" evidence="9">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit 1/RPN2 N-terminal" evidence="9">
        <location>
            <begin position="192"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome regulatory subunit RPN2 C-terminal" evidence="8">
        <location>
            <begin position="875"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="356"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="900"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1107"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="357"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="908"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="935"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="960"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="976"/>
            <end position="990"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL26870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1130" mass="123384" checksum="02E091848D0C912B" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKG8</accession>
    <name>A0A0G4PKG8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S020g000051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793153">
        <property type="protein sequence ID" value="CRL26892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKG8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PKG8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL26892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="185" mass="21906" checksum="5737B2215E3EE7A4" modified="2015-09-16" version="1">MKNPVKQMRFPALEDFVEYVQDVAETSGRWVNWQIIRGKRHIWWETDWDVVSRWAQSIIETEERLRETTQRENFHKKWIHKFHNGSSEAGKFVLPDLIEELIALGHEYTRLERIYDTLLVGCPVGPIKSGYMWIRKQPQWYLKSEWLRQDCARRGGCCGRECKCCENPPDPNRRKEGSKEVAAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKJ5</accession>
    <name>A0A0G4PKJ5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S020g000018</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="HG793153">
        <property type="protein sequence ID" value="CRL26859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKJ5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PKJ5"/>
    <dbReference type="ESTHER" id="penca-a0a0g4pkj5">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005118200" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="23"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL26859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="549" mass="59588" checksum="31938683EC1C125F" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKM2</accession>
    <name>A0A0G4PKM2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S020g000114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793153">
        <property type="protein sequence ID" value="CRL26955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKM2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL26955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="102" mass="11413" checksum="4F91C4344D0D56FD" modified="2015-09-16" version="1">MNYDFPEVMIVGGRWRSATVYTRDDDTRPIITCTTLDSLAEHLAMSTSMDGVRLSCASPVEGSHMAYCPKMWLRLKVDTHSYSSADRTPMSATPNTFKGMKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKZ0</accession>
    <name>A0A0G4PKZ0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane adaptor Erv26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S021g000012</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SVP26 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793154">
        <property type="protein sequence ID" value="CRL27097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKZ0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PKZ0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097020">
        <property type="term" value="F:COPII receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007277">
        <property type="entry name" value="Svp26/Tex261"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13144:SF0">
        <property type="entry name" value="PROTEIN TEX261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13144">
        <property type="entry name" value="TEX261 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04148">
        <property type="entry name" value="Erv26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL27097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="226" mass="25268" checksum="E2DAC1F1D1E9B690" modified="2015-09-16" version="1">MWILPLVGYFGVVVGFAFLTLAIASGLYYLSELVEEHTVLARRVLTRLIYGIVAIQVLLMIIDRFPVSLSLLSIASHMVYASNLRRFPIVKLTDPLFLLSCLLVGLNHWLWFRHFSKPLPPSNNWRQPYGVNYDEMPSFSEVASYFGLCVWLVPFALFVSLSAGENVLPSMGSEYVTGANPTGLGPSDAKSKNKGMAKALVDGVRDWTSETGELMGLWRGDRTKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PL05</accession>
    <name>A0A0G4PL05_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleotide-binding, alpha-beta plait</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S021g000025</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793154">
        <property type="protein sequence ID" value="CRL27110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PL05"/>
    <dbReference type="STRING" id="1429867.A0A0G4PL05"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030626">
        <property type="term" value="F:U12 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12246">
        <property type="entry name" value="RRM1_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000572">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045164">
        <property type="entry name" value="RBM41/RNPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16105">
        <property type="entry name" value="RNA-BINDING REGION-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16105:SF0">
        <property type="entry name" value="RNA-BINDING REGION-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="24"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="136"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL27110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="188" mass="20201" checksum="39676A6F7B0C2949" modified="2015-09-16" version="1">MASKSLPARGGPDSKAVATGAPNQTLYCTNLPDRRIQKNDLRTALYALFSTYGTVLDVVAMKTAKMRGQAHIVFKDVQASTQALRALQGFEFFGKQMKIVYAKGSSNVISKLRGTYVAPVEAAPAPVTTDLQKSIFGAPPGALPARPTTDVNGEAHGLKRPREEESDNEEAPMDEDSDVPMEASSDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PLF4</accession>
    <name>A0A0G4PLF4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S021g000175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CRL27260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        </location>
    </feature>
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            <begin position="180"/>
            <end position="206"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="241"/>
            <end position="383"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="474"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
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        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
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            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
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            <begin position="261"/>
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    </feature>
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            <end position="313"/>
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            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
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        <location>
            <begin position="461"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="566"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL27260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="628" mass="68424" checksum="1D1FE4F2CEF3FF07" modified="2015-09-16" version="1"> </sequence>
</entry>
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    <accession>A0A0G4PLP8</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Dupont J."/>
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                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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                <person name="Debuchy R."/>
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                <person name="Bensimon A."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
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        <subcellularLocation>
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        </subcellularLocation>
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        <text evidence="4">Belongs to the complex I LYR family. SDHAF1 subfamily.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL27106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PLU9</accession>
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        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
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                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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            <end position="172"/>
        </location>
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            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="CRL27385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="212" mass="23618" checksum="F0D115F313F80592" modified="2015-09-16" version="1">MLHSKKIDLQNYINLRLVIRPEEFWASFPIDGKLVINEGGAAEAVSGNDAASTLVSHGAASLSRRKHPELRTPTRAVGDVVRIPGSAVRTKEWQALLLQPLPQHSSAAPATLPYQRVYDSASGSPAEGGPVSDAPPLGLAPGRLYQINPVGHNQPTTTQLQRKRAQRQRRKDPICDACRERRVRCQFTKETNRRILYIEQFQDLEKQLQNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMA6</accession>
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    </protein>
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    </gene>
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        <lineage>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195468" evidence="1">
        <location>
            <begin position="19"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="483" mass="52494" checksum="F395AB01A4D5AB66" modified="2015-09-16" version="1">MLPGPIVALLGHIPFIIASSLPTEYTATASSDDNYGNKLIGIVSNRQSASDYDDDMKRAQYAGIDAFALNIGTDSYTDTQLGFAYQSAANNGMKVFISFDFNWWQTSQGNAVGAKIAQYANLPAQLKVDGKVFVSSFAGDGVDIAAIRAAADSDIYFAPNFHPGRGDFSNLQAALNWIAWGNNGSNGSPTPNKQLVVADSDNAYKTALNGKPYIASVSPWFSTHFGGDVSYTKNWVFPSGLLWYNRWREILATSPRFVELLTWNDYGESHYIGPLSSPHIDDGASKWVMGMPHNGWLDMAKPFIAAYKAGSKLPIRFLDEEKLVYWYRTTPKNVNCDATDTTMQGCSNSWSGNFVCGRPDGADNMTDEVFIVTMLKTPATVHVQSGREAETYDAKPGMWSHSVPMGVGRQSFKVVRDGKTVDSLCGIGRRDITDTCPCGIYNFNAYVGTLPAEASVDRLQPAGLALLSQGLQIACPTSTLGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMK7</accession>
    <name>A0A0G4PMK7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S022g000056</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793155">
        <property type="protein sequence ID" value="CRL27376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PMK7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PMK7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL27376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="70" mass="7657" checksum="538C15070E23C396" modified="2015-09-16" version="1">MYVLVDCPNLREVRRKLRSEAGDAFNSVSSLLGGSTEGERGKPDTVSRARTVKAVLDFAEASQQFQSRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PN65</accession>
    <name>A0A0G4PN65_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glyoxalase/bleomycin resistance protein/dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S024g000097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glyoxalase I family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793157">
        <property type="protein sequence ID" value="CRL27842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PN65"/>
    <dbReference type="STRING" id="1429867.A0A0G4PN65"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07253">
        <property type="entry name" value="GLOD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050383">
        <property type="entry name" value="GlyoxalaseI/FosfomycinResist"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21366:SF14">
        <property type="entry name" value="GLYOXALASE DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21366">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="9"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL27842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="138" mass="15486" checksum="8F8EBE58F3BD8BE6" modified="2015-09-16" version="1">MTGKFAVKSLDHLVLTVRNIPKTVAFYTTYLGMRHEIFTSPTNQSIQRHALIFGSQKINLHQSGKEFEPKAQDVMPGSADLCFLTDENVEKVLEVFQDARMEILEGAKVVERTGAVGKIRSVYVRDPDGNLIEVSNYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNQ9</accession>
    <name>A0A0G4PNQ9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S025g000150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793158">
        <property type="protein sequence ID" value="CRL28092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PNQ9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PNQ9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL28092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="112" mass="12253" checksum="BF357373566435CA" modified="2015-09-16" version="1">MRFDFNLHYDGESSHAKVIAAMGCNCGLTTYDAYALSRIDRKLGYSPEDELVTEIRAISLFSSTLHGLGVHVELHLSPGHARIPGNVATDGMAKKTQRKLFLQTTKSGLTMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPR2</accession>
    <name>A0A0G4PPR2_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Armadillo-type fold</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S026g000083</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Tango6 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793159">
        <property type="protein sequence ID" value="CRL28218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PPR2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019451">
        <property type="entry name" value="Rtp1_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019414">
        <property type="entry name" value="Rtp1_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039600">
        <property type="entry name" value="TANGO6/Rtp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959:SF1">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10363">
        <property type="entry name" value="RTP1_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10304">
        <property type="entry name" value="RTP1_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase II assembly factor Rtp1 C-terminal" evidence="4">
        <location>
            <begin position="745"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase II assembly factor Rtp1 C-terminal" evidence="3">
        <location>
            <begin position="1072"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="879"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="879"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="893"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL28218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1156" mass="125494" checksum="C51811ECF90BA1CE" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPX5</accession>
    <name>A0A0G4PPX5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S027g000089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793160">
        <property type="protein sequence ID" value="CRL28400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PPX5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195516" evidence="1">
        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL28400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="53" mass="6317" checksum="2848D108F578EB36" modified="2015-09-16" version="1">MVWNLISFLGFVITPESVLLWDPGFSDSFEYTMLFRLLKRWLHVVLPDLLRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQ04</accession>
    <name>A0A0G4PQ04_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S028g000002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793161">
        <property type="protein sequence ID" value="CRL28449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQ04"/>
    <dbReference type="STRING" id="1429867.A0A0G4PQ04"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL28449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="94" mass="10790" checksum="C0A40A9C9978DDB8" modified="2015-09-16" version="1">MFALSTWKWPALARTDETRAITDFIRDQHLDLKKDAAKLPTKAVTDLELLEIPRLFFLTKNDPTDDELRPKDHEMVTLPAQLGILTDHPPIKPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRD4</accession>
    <name>A0A0G4PRD4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S032g000015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793165">
        <property type="protein sequence ID" value="CRL28979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PRD4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PRD4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF6">
        <property type="entry name" value="OXIDASE USTYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL28979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="179" mass="20954" checksum="378558E04C8AEABF" modified="2015-09-16" version="1">MTHSDEMWDNINLDAMVIAPTIEWAQDMGLTDSWDFPWDPKRKIYFLKVIHQLHCLKNIRRAVKQLMSKEENNVKFAHIEHCLDTLRQDLMCKADDTPMPSLELVNAAGEGQVLKCKNFDKLIAWAKHPDRDACYKRGNDYEPPLHSIDRYAFCPPSSEHFPIMSQYFMDRGYSVNFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRR4</accession>
    <name>A0A0G4PRR4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">P-type Ca(2+) transporter</fullName>
            <ecNumber evidence="2">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCAMFM013_S033g000032</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="2"/>
    <dbReference type="EMBL" id="HG793166">
        <property type="protein sequence ID" value="CRL29112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PRR4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PRR4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000031">
        <property type="entry name" value="Calcium-transporting ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000040">
        <property type="entry name" value="Calcium-transporting ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000028">
        <property type="entry name" value="Calcium-transporting P-type ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="377"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="907"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="988"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1018"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="15">
        <location>
            <begin position="42"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="166"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CRL29112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1060" mass="113623" checksum="72239D6218798BD8" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRX0</accession>
    <name>A0A0G4PRX0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATPase-like, ATP-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S033g000102</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
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        </location>
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        <source>
            <dbReference type="EMBL" id="CRL29547.1"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793170">
        <property type="protein sequence ID" value="CRL29580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PT56"/>
    <dbReference type="STRING" id="1429867.A0A0G4PT56"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL29580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="358" mass="41778" checksum="283975B75BEA9FCB" modified="2015-09-16" version="1">MHRFQRACIWKRLANERRFEVKLAVNRPIFSSHIYSINKLARQYSTPRNVPCEIPARQLESKTHPLGWKQIQAQVEPYFGNNWNFASEKEKKGFLCIGFSRAFSHLFPLTLDDRINLTCKMLYLSLLIDDQLEKMSFTQMLSYRDRVMTIALGTASPDRSICLEWMLHDTVLAMRSMDEVLANDVAQGFCQLLQAQTSQERSTIKTLGSYLKFREIDVGRPFYTALIRFGAKLYLATPELKKSAALESTAFRHVSVMNDIYSWEREWKVYQANPTDGARPFSAIYILANETGLPYAACKRLMYSYCRELELALKQSTDEIRHNSMGSLTYELEMYIKGLEYFMCGIELWSQWTPRYRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PTP3</accession>
    <name>A0A0G4PTP3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S039g000035</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793172">
        <property type="protein sequence ID" value="CRL29726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PTP3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PTP3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052479">
        <property type="entry name" value="GPI-anchor_Adhesion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185">
        <property type="entry name" value="SERINE/THREONINE-RICH PROTEIN ADG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185:SF1">
        <property type="entry name" value="UPF0619 GPI-ANCHORED MEMBRANE PROTEIN C1322.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195727" evidence="3">
        <location>
            <begin position="18"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="22"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="281"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL29726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="394" mass="39847" checksum="2BCB3C312533E3D9" modified="2015-09-16" version="1">MRVNIISLVALATTVAGLTVTSPRIGEKIDPDLPLTIKWQAVTTDPETFSIELVNQNVYPPTTTIVADDIDSSKGSYTVKAKTFTDVDNGKGYQINFLSPDSGILAQSQQFRVTEPGEIASSASASSSGKETSTALDTSSLISSTASTSDITSALSSSTASSYLSSTATHSSISASTPTSYYSTASSSISTPTTSSFISSSASASTYSILSSSTSTPETSSYLPSTSSSLIFTTSSTSTLTLTTPSSSSVSSISTLETSSSISSTSTPSTSSFITTSSSIISSSSATPTTSTSITKSSTHLPTSTFLTSSTLSSTTSHSTHISTSTPVSTSASTVSSTSLSTATHSSTTSTTTRKTTSTTTSTATESASTTSNAAAVLMPPAGSLLLGLFALVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PTY7</accession>
    <name>A0A0G4PTY7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger, CCHC-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S042g000014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793175">
        <property type="protein sequence ID" value="CRL29955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PTY7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PTY7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000012">
        <property type="entry name" value="Cellular nucleic acid-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000016">
        <property type="entry name" value="Cellular nucleic acid-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000085">
        <property type="entry name" value="Zinc knuckle nucleic acid binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051714">
        <property type="entry name" value="Znf_CCHC_NABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23002">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="167"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL29955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="232" mass="23109" checksum="5C99B7D5E0107B86" modified="2015-09-16" version="1">MLVCSSTERLCYNCKQPGHESSACPLPRTTETKQCYNCQGLGHVQADCPTLRLNGGANGRCYNCSQPGHLARNCTNPAAPGAGAPPTGPAAGRGAGGARGGFQGGFRGGFSGYPRAATCYKCGGPNHFARDCQAQAMKCYACGKLGHISRDCTAPNGGPLSSAGKVCYKCAQAGHISRDCPTNEGAAAPVAAVEAAPVAAAPVVAAAPAVVAVETATEANTAPAAAPTTAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUB5</accession>
    <name>A0A0G4PUB5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycosyl transferase, family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S042g000047</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793175">
        <property type="protein sequence ID" value="CRL29988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PUB5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PUB5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06434">
        <property type="entry name" value="GT2_HAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052427">
        <property type="entry name" value="Glycosyltrans_GT2/GT47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844:SF1">
        <property type="entry name" value="EXOSTOSIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844">
        <property type="entry name" value="SYNTHASE CPS1, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G02500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13641">
        <property type="entry name" value="Glyco_tranf_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195629" evidence="8">
        <location>
            <begin position="21"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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    </dbReference>
    <dbReference type="Pfam" id="PF07217">
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    </evidence>
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    </evidence>
    <sequence length="876" mass="98147" checksum="8A3EAA8678AB74BB" modified="2015-09-16" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
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</entry>
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    <accession>A0A0G4PUX8</accession>
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            <dbReference type="PubMed" id="24407037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <location>
            <begin position="31"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL30228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="85" mass="8816" checksum="51FF67144B2FA8E5" modified="2015-09-16" version="1">MYPDSDCAPPLVFILSLTNATGTNPVPRFPGSDSASTSDSSIGTGTRSGAASAHFSGTADSVLHSGFHNHFRPSSGVETHYSIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PV17</accession>
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        <submittedName>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Dupont J."/>
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            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF58">
        <property type="entry name" value="PROTEIN HMF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL29977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="126" mass="13254" checksum="6513DAFF4CB6F2F3" modified="2015-09-16" version="1">MSANMSIISAKDACPPAGPYSQAIRANGQIFVSGQIPADASANLVEGNIGAKTQVCCDNIKAILTAAGSSVDKIVKVNVFLTDMANFAEMNATYEKFFVHKPARSCVAVHQLPKGVPVEIECIALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PV27</accession>
    <name>A0A0G4PV27_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S047g000011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793180">
        <property type="protein sequence ID" value="CRL30283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PV27"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL30283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="164" mass="18556" checksum="C7D93F6B924CF93D" modified="2015-09-16" version="1">MHCLSSESLRSLLPNWIQSLWISEGEQNRERLDQTVPTVPSPYTRTEPAVYKLQNSEVAYNVTKPLPVCISNQTERLPRTRTKPLENYISTRPQAISETIVLPDIPPGVKFVKGRITCMGEERPSPEWSTMYLKNKKLAVIMLSNIGQGSSLQQRACVIVVVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PV36</accession>
    <name>A0A0G4PV36_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S048g000042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793181">
        <property type="protein sequence ID" value="CRL30330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PV36"/>
    <dbReference type="STRING" id="1429867.A0A0G4PV36"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="456" mass="51380" checksum="F9A8D02DFE8A1014" modified="2015-09-16" version="1">MGITESKILQVKLAAACSDAEDNGRNQVLHVLSDKQFIDCLTTIWRNLPDRSKKQINPISRIRPKHPQKAEKGSIRLPEPLKKNLIQWQGDHTSFWNIQRAHSPSESCHITAIYHELTKMEIQNSGDMVRMRFLKVFFHHLKVRFCATNLGLDAVEWMTRKVILAGAYQAEKDEISAKIRAWALVGSRYDSLCRDIGEYNVAQDYTYLGTLIRLPEEFTDRYMLKELRVKGRDREDVLDSLARRGVGKVDHVAEMDRLANDIFLKLWESIDSSTTDEAPHGGMFVSLKDWRILQSTRVIKLQNKVPQATQRPDHETNINHASSTSTIPTPASESVIREGASDCQDVGISRSMSMIDSRTADCTMTASATSHSDNTSQVHPVDSDYLDTMNVMPHMENASRIHPMDAVYPDTMNVMPHMNTASRIHPTDADYTMGGAPHGGRGQIYDGCVVNTSICT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVE1</accession>
    <name>A0A0G4PVE1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotide-binding, alpha-beta plait</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S045g000005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793178">
        <property type="protein sequence ID" value="CRL30139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PVE1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PVE1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="307" mass="32783" checksum="E6FEF11ECB63CBFD" modified="2015-09-16" version="1">MDAGSDAGDDRGGRRSNFESDGKPRDFNNWERKGPLSPSAGGPPREGGREHSNDGPGSSFRRTEAAWGEGRSQDEGSRPPRPEHVRPEPTPTAADMDNQWRARMRPDETPKEPISPASPSATPAVPAAPASRPKLNLTKRTVPENPTPTSASSDSKASPFGAARPIDTATRERQVEERRQLAIRQKQEAADKAKAEKAEKFAEKQKQLKESAPAVDHNGKDALETPKGGGNFEILQRAGEDGELTADQETEETTAAAPVEAKKASANGWRAPAPEAGAGAGGDDEGWSTVSVNKRNNRRGQTGRGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVE5</accession>
    <name>A0A0G4PVE5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription factor, MADS-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S048g000055</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793181">
        <property type="protein sequence ID" value="CRL30343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PVE5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PVE5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="6">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL30343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="85" mass="9626" checksum="FF6EE332E30B4E2B" modified="2015-09-16" version="1">MVVPQKSETNLADAVNQKARRRRRTLFKKASEYSSECGADIHIVLRMKKSGKIFILTSNSEGWPLSQNQLMSYHPTPIHTSPESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVR5</accession>
    <name>A0A0G4PVR5_PENC3</name>
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        <submittedName>
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    </gene>
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        <lineage>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CRL30247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="153" mass="17568" checksum="A8C4100D128C5F05" modified="2015-09-16" version="1">MMENSTYYAMNGGLGQLFRKLLYDHLQDERPKATEVVYQCSAPHRGTSVKLISAEELDELAKQPSSSDFNVGNPRIRILGQLVDSRSTNFYHMQREIRKTEKIPGREDLIQVLWFEHYWASHTELIKSSIGRDLLQAGTSKGPLPKDHPFNYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVS6</accession>
    <name>A0A0G4PVS6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PCAMFM013_S046g000061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793179">
        <property type="protein sequence ID" value="CRL30257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PVS6"/>
    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195782" evidence="1">
        <location>
            <begin position="20"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="135" mass="14181" checksum="B77C5287ECB26A91" modified="2015-09-16" version="1">MHLSVFALLAILYAQHSAGSTLGIVDVGDQCMIWSNGNHGCTGHSSPFALPNEEDCSKLGGAVNGTSRDLPMVSVEACSTAEGLPAVWILLEKTGRVTFFNKQGNISACTLSDGLRVGSTCNAVHPEALWNPSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PWW8</accession>
    <name>A0A0G4PWW8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S061g000034</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793194">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL30860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="77" mass="8995" checksum="A94C61B1574EBA56" modified="2015-09-16" version="1">MAQVIAPFESLNLILTECLTASGPMRGFIIRDQALKLLKYIQTYTEEYNLFQNPRVYFEIGRWMERLSPGNHDEQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PXV2</accession>
    <name>A0A0G4PXV2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S083g000007</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
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                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793214">
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    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PXV2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Serine hydrolase" evidence="3">
        <location>
            <begin position="15"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL31180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="124" mass="13937" checksum="BB2C055D2EEB78B8" modified="2015-09-16" version="1">MPDKVLKVLMLHVHDMTFEFQFLSGILPADPDRDEGNDRWVWGYGGLSDGKIKKIDLSIKHILNTLDRDGPFVGIVGFSSGAAMAAIITSLLEKRQTVCDVTGKVNWPFSVVRSRWHKLTIRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PYT7</accession>
    <name>A0A0G4PYT7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S4Jg000046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
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                <person name="Lacoste S."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793313">
        <property type="protein sequence ID" value="CRL31524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PYT7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL31524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="65" mass="7473" checksum="5B960C42C1496D00" modified="2015-09-16" version="1">MFQPFKVYNFIDTYLVTELKDLAFKKFTAVVINLGKPKNLDKQLAVIDCLSLAFPKSSLHDKLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NSI2</accession>
    <name>A0A0G4NSI2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Basic-leucine zipper (BZIP) transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S001g000001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4NSI2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14705">
        <property type="entry name" value="bZIP_Zip1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR ATF 4/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044:SF14">
        <property type="entry name" value="CRYPTOCEPHAL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="175"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="167"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="234"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="261"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL17041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="276" mass="30364" checksum="8913EA4149313513" modified="2015-09-16" version="1">MPGEQPPLPGPGPVFDKLENFNFLMSRHDPAAKTRQYSFDADTGLVPFGNVSMDYDQTEGMGGLSVSSYESIEDDRSSLDLRGYPYHGPPGEKSVNYNLPEHMMPYSAHSIYPPVPYAPDELGHAQGALTPSDVSSSISPPNGQMGNTKYSTTISGDRIAAALDQEEGVRGAAEEDRRRRNTAASARFRQKKKQREQVLERTVRETTEKNAALEARVAQLEMENRWLKNLLTEKHDAGSRLPAPAKDSSALELKGPGANTRQKHIQPKKKGVGTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NTI0</accession>
    <name>A0A0G4NTI0_PENC3</name>
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        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL17323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="89" mass="9587" checksum="57CB9A8FCA05803A" modified="2015-09-16" version="1">MPPGAITSTLTITITTHGPIINLGSHPQHNLTGYPLDPQATKPLLTLISQKKKKKKEKRKKESPPITPPQGCTGPVLQSNPTGTNYIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NU23</accession>
    <name>A0A0G4NU23_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S001g000536</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4NU23"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042578">
        <property type="term" value="F:phosphoric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956:SF1">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005194791" evidence="2">
        <location>
            <begin position="20"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL17576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="477" mass="54097" checksum="F32AF66AB52BB093" modified="2015-09-16" version="1">MILHWGFVILTALASLASTYPTGGARVWGQLRENIKHVIYLTLENHSFDNIAGYWDFHPEIDNLRNLTYCNDYTNPNWTVYGEPLAICAEPYATEVPLEDPDHNFGGVTYEIFRQWNPTNEDVPNMGGFIERQSERYNATPGDSAFVIKALSQKKTATLVELASNFAFFDSYFAEHPGPTNPNRQFATSGSSCGFVDNTNQSAGFWNNVTGTTCAVSIFESLSKKNISWKNYYETDIVDGFMYKWVQDNAMDHLVHATELYHDLEAGTLPSFSYLNPECCIVDSMHPTSSMAAGEQMVKHLYDALRRSKYWDNAVLIINFDEHGGFADHVPTPVKVPQPEDGIIFKGRSSNHNFTYDFTRLGVRVPAFIISPWVPANLLIHDQGTMYADNSAYTHSSILHFLQELWGLEGLNNRVQWARTFETVFTNKRRDDTPKTLVKPTWYGGSGQPEPESFFLLNQDESYYARRQAEAKARAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NU55</accession>
    <name>A0A0G4NU55_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dimeric alpha-beta barrel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S001g000581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NU55"/>
    <dbReference type="STRING" id="1429867.A0A0G4NU55"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="27"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL17621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="125" mass="14085" checksum="134F9D18719B5603" modified="2015-09-16" version="1">MVATFIDINPRTPLLKQLEEQPEAGSCVLVNTFHIPAGKMEEAFAAWKIDAEMAKKQPGFISTQLHRGVNGSDMMLNYAIWESTAALKAYYDLPEFKESLKNYPDGTESRIVLYRKQKIDGICLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NV49</accession>
    <name>A0A0G4NV49_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S001g000809</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A0G4NV49"/>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL17849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="34" mass="3906" checksum="57EDA9FFD6DA7178" modified="2015-09-16" version="1">MFLELFSDVIHIVPHLNPSSLHAKKASHLLLKLR</sequence>
</entry>
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    <accession>A0A0G4NVB7</accession>
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        <name evidence="4" type="ORF">PCAMFM013_S001g001001</name>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="542"/>
            <end position="658"/>
        </location>
    </feature>
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        <location>
            <begin position="656"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="744"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="656"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL18041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="812" mass="89236" checksum="F78BE14D9702074A" modified="2015-09-16" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Conseiller E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GUANYLATE KINASE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117">
        <property type="entry name" value="GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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            <begin position="1"/>
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        <source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL18076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="200" mass="22479" checksum="0110F1AF3AF1B69A" modified="2015-09-16" version="1">MAVDDMASSKPQDRRPLVISGPSGAGKGTLIQKLIDAHPNTFELTVSHTTRQPRPGETDGISYHFVSVETYKALESNGGLLEDAMYTDDFYGTSKAALEEIFERQLIPILDIEMNGVQQVKVNPEFDARYVFIKPRGLGVLEQRLRGRGTEGEEKIQARLERARRELEFAETAGVFDKVIVNDDLEKAYIELERFVFGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXQ8</accession>
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    <protein>
        <submittedName>
            <fullName evidence="4">Beta-lactamase-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S002g000710</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
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                <person name="Branca A."/>
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                <person name="Silar P."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NXQ8"/>
    <dbReference type="STRING" id="1429867.A0A0G4NXQ8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058664">
        <property type="entry name" value="ARB_00930-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051478">
        <property type="entry name" value="Beta-lactamase-like_AB/R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935:SF97">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26335">
        <property type="entry name" value="ARB_00930_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005194873" evidence="1">
        <location>
            <begin position="20"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="106"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-like ARB-00930-like C-terminal" evidence="3">
        <location>
            <begin position="438"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL18840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="580" mass="62227" checksum="668C3309E6DEE65A" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXS3</accession>
    <name>A0A0G4NXS3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S002g000721</name>
    </gene>
    <organism evidence="4 5">
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NXS3"/>
    <dbReference type="STRING" id="1429867.A0A0G4NXS3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005194991" evidence="3">
        <location>
            <begin position="21"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL18851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="260" mass="27847" checksum="4689B7F4668D9042" modified="2015-09-16" version="1">MRQAGFLILFLAGIASLVAGSDPDNYFTNPADNTGINPVYALGDKLVISWKTTLDVFNVSIWQQSLVETGAASQGNIYSKIHSSDKVTNFTWVVQVYGFDLSYSNEFFLWVNPDEKGGFVSTYFNITEPTSTTSTTSSSTSTSTSMKTLNAATTPSSPSSSSSSSSSDSDSQTSELTLTGKIAIGVGAGVGLPILCALGALLYLKTRKSNNKIEKTISPPEPMPPWMVMQNQHGQISSPKEVHGSSLKASFAELPNQPYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXZ5</accession>
    <name>A0A0G4NXZ5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S002g000796</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NXZ5"/>
    <dbReference type="STRING" id="1429867.A0A0G4NXZ5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF32">
        <property type="entry name" value="ARGININE METABOLISM REGULATION PROTEIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="65"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL18926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="200" mass="22217" checksum="52702B8A765664D8" modified="2015-09-16" version="1">MPPTEKQKDISHRHRSFKGCWTCKKKRIQCDEMRPACRKCSSRGLTCEGYEIRLRWGAGIASRGKYSGAEKPVKESIPPQSKRRWDMRDKGGKPYEDGDVQPVLISQSLTKEGISSTSRCYGVPGSHILSDREPRLIAERATVNILNSPWEPGSPRSSAINKHFEIPTSLATLTATTAYGRGPDISGQYAKNAGRRSILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NY89</accession>
    <name>A0A0G4NY89_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gamma-glutamyltranspeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S002g000900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL19030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NY89"/>
    <dbReference type="STRING" id="1429867.A0A0G4NY89"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL19030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="138" mass="15901" checksum="2301F55E59ACDF74" modified="2015-09-16" version="1">MNICSKINFLKRKSFHDAESLSSHILDNIHARPRLHDQLVPIQVPFEYDYDNSTVEYVKQRGHNVTWTNPRLPDWSEAEAIRVLQNGTFEAAGDQTVGLWWLCDIMSGRRDSQQYIAKMAIRPRTLVPRGVELRPVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYC7</accession>
    <name>A0A0G4NYC7_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">GDP-mannose transporter</fullName>
            <shortName evidence="13">GMT</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S002g000948</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 13">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasmic vesicle membrane</location>
            <topology evidence="2 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Golgi apparatus membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Endoplasmic reticulum membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL19078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NYC7"/>
    <dbReference type="STRING" id="1429867.A0A0G4NYC7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="13">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="13">
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            <end position="221"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="233"/>
            <end position="254"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
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            <begin position="1"/>
            <end position="39"/>
        </location>
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        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
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            <begin position="365"/>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU367097"/>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="EMBL" id="CRL19078.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="378" mass="41292" checksum="4370712EC46486AF" modified="2015-09-16" version="1">MAEDKKSDDYTVEMNKLDQGNKEFEAAPPPTPSPRASPNISNNPALPVLAYCGSSIMMTVMNKYVLSGLDFNLNFLLLCVQSLVCIAAIQTCKSMGLITYRDFNTDEARKWFPITLLLIGMIYTGSKALQFLSIPVYTIFKNLTIILIAYGEVLWFGGSVTNLTLFSFGLMVFSSLIAAWADIKHAVESTGDTSSKVSTLNAGYVWMLINCLCTSSYVLGMRKRIKLTNFKDFDTMFYNNLLSIPVLIVLTLLVEDWSSANLARNFPEANRDGIFFAMVLSGASSVFISYTSAWCVRTTSSTTYSMVGALNKLPIAVSGLVFFDAPVTFPSVSAIGVGFVSGIVYAVAKIKQNSKPRTGVLPTPVSASSQSMRDSLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYJ2</accession>
    <name>A0A0G4NYJ2_PENC3</name>
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        <recommendedName>
            <fullName evidence="3 10">Protein ROT1</fullName>
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        <name evidence="12" type="ORF">PCAMFM013_S002g001010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Required for normal levels of the cell wall 1,6-beta-glucan. Involved in a protein folding machinery chaperoning proteins acting in various physiological processes including cell wall synthesis and lysis of autophagic bodies.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
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    </dbReference>
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    </dbReference>
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    <proteinExistence type="inferred from homology"/>
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    </evidence>
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        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="226" mass="25279" checksum="64EE83E922B5A1CB" modified="2015-09-16" version="1">MFLICSLLITAALANANDLVGTWTTKSRDVLTGPGFYDPLNDKLLEPNLTGISYSFNDDGNYESAYYRAISNPADPSCPGGILQWQHGAYTVFGNGTLILTPIAVDGRQLLSDPCRKESGQYTRFNTTEEFKEFSVYVDKFNRIKRLDLTRVDGSLVHPMFLAYQPPKMLPTTTLNPTPTGHKRKRELSSKSGLQLIAREQLINPDRWWWLGVLMTSLGGVAFFCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZ07</accession>
    <name>A0A0G4NZ07_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Spc97/Spc98</fullName>
        </submittedName>
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    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S003g000098</name>
    </gene>
    <organism evidence="9 10">
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            <taxon>Eurotiomycetes</taxon>
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            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1429867.A0A0G4NZ07"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF14">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="280"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="582"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="172"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="867"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="969"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="874"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="977"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1008"/>
            <end position="1020"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL19307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1032" mass="114436" checksum="384D4B2B6A00F494" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZ48</accession>
    <name>A0A0G4NZ48_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glucose-methanol-choline oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S003g000118</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZ48"/>
    <dbReference type="STRING" id="1429867.A0A0G4NZ48"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051473">
        <property type="entry name" value="P2Ox-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42784">
        <property type="entry name" value="PYRANOSE 2-OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42784:SF1">
        <property type="entry name" value="PYRANOSE 2-OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="9">
        <location>
            <begin position="124"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="10">
        <location>
            <begin position="378"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL19327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="503" mass="54976" checksum="202D2442A3A0ED51" modified="2015-09-16" version="1">MAGQDITTDLLIIGSGPVGATYARKIAELSANSQKKPKITMLSLDGRYEALTAPLTCATPEPHQTELPGKYRPEDWGTLMKEAKELIDVNNTAFDETSLRQAIVKETLAKSFEGRQVESLPLACKTDPTDGSARWSTVSTILGDLIDLKSSKAEQFELLCDHLCTKLVFQDPSNEDNNQIAHAIVKDLEQGREKKVTARYYVICGGGIKTPQLLFSSGCEQSGSSDRLPALGRYLMDRKSALCQVILKKDLTDAVPKANSKVWQGLINEHKQKHPEDNISIPKSDPEPQVALPFSEERPWYTEIHRDPTLSNSEGNSQSTMFGGNPALPNSQWNSQSTMFGGNPASSSTPSSTIDQRVVLHLQSFGYSTPNAANCLQFRTDIVDRWGMPMYEARFEQNTEDNERAHKMMSDMTEVAARLGSYMPGATPQFGGLDKAPDGYGTTRVGSTKDDSCVDANFCVHNSTNLYLGGNSVIPTGFAGNPILTTIGFAIKGASDLYKKMAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZ92</accession>
    <name>A0A0G4NZ92_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Peptidase, cysteine peptidase active site</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S003g000169</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4NZ92"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17936">
        <property type="entry name" value="EEXXEc_NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001660">
        <property type="entry name" value="NF-X1 finger and helicase protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046439">
        <property type="entry name" value="ZF_RZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000967">
        <property type="entry name" value="Znf_NFX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF445">
        <property type="entry name" value="NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20173">
        <property type="entry name" value="ZnF_RZ-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00438">
        <property type="entry name" value="ZnF_NFX"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51981">
        <property type="entry name" value="ZF_RZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="RZ-type" evidence="12">
        <location>
            <begin position="1841"/>
            <end position="1917"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL19378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1919" mass="217022" checksum="416D59A2F958D57A" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZB0</accession>
    <name>A0A0G4NZB0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcriptional activator of proteases prtT</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Zn(2)-C6 zinc finger-containing protein prtT</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S003g000135</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the prtT family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZB0"/>
    <dbReference type="STRING" id="1429867.A0A0G4NZB0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF34">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR OF PROTEASES PRTT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL19344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="547" mass="61579" checksum="2013BEC17113D250" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZB5</accession>
    <name>A0A0G4NZB5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S003g000198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4NZB5"/>
    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="701"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL19407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="834" mass="92165" checksum="414CE0A37A37C4AE" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0M7</accession>
    <name>A0A0G4P0M7_PENC3</name>
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        <submittedName>
            <fullName evidence="1">Aldose 1-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S003g000620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4P0M7"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:carbohydrate binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047938">
        <property type="term" value="F:glucose-6-phosphate 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122">
        <property type="entry name" value="APOSPORY-ASSOCIATED PROTEIN C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122:SF13">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL19828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="190" mass="20440" checksum="9B0CA816EDB99E01" modified="2015-09-16" version="1">MDRSNKPSAIGVKASLPQSTLSIKDNVVDASLPTGQSVTVHLYGATVTSWKTGGQEQLFVSEAAHLDGSKSIRGGIPVVFPPRHAMSGEGHSLPFYGPNLDARNRQPFSVPLSPRVDPYVPYSQSTFSPEQVVQLLTIQQQNELVLSQTLMSVGNPAFSQECVCDFSVDSAFCQTALRCRKSSSSIAEPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0Q3</accession>
    <name>A0A0G4P0Q3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ARF/SAR superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S003g000692</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable lipid hydrolase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4P0Q3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07229">
        <property type="entry name" value="Pat_TGL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF44">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="PNPLA" evidence="11">
        <location>
            <begin position="194"/>
            <end position="387"/>
        </location>
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        <location>
            <begin position="554"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="581"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL19900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="591" mass="66712" checksum="FD0E9FCA4A79EB26" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P1G4</accession>
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        <submittedName>
            <fullName evidence="10">Nucleic acid-binding, OB-fold-like</fullName>
        </submittedName>
    </protein>
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        <name evidence="10" type="ORF">PCAMFM013_S004g000058</name>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP4 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CRL20118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
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        <location>
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            <end position="95"/>
        </location>
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        <location>
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            <end position="179"/>
        </location>
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            <end position="237"/>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF14382"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF21266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL20118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="392" mass="42022" checksum="9E3DB1A536011D1E" modified="2015-09-16" version="1">MAITILPPVVEDARPYEVDSDDDISMDSEEDIEMTGISRPHKRPRLQGNSNIGAGIVTPGEVVTDDPQWMRGHGTYMNPLSTSIIATVAGTVQKTNKLLSVHPLRARYTPEIGDLVVGRIVEVQSRRWKVDVAAPLLAQLPLSAINLPGGILRRRTSADELQIRTFFSEGDLVVAEVQSVHQDGSASLHTRSLKYGKLRNGVFLAVTGTGGSGASSSSVKGGVGAGKSASGSTLAAPGGSGTGGVVRSRRQVWTVPTANGGGEVNIILGVNGYIFISKHAEGEDAASSTTENVSITRMEEMVSSSIYSSQNDDISPQTRREIARLAQCIRVLVQSGVRVDEETVMGAYNASLQVDLEIGDDEDEEDEWRQEGREYLEGAKAQQILELVKQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2D1</accession>
    <name>A0A0G4P2D1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S004g000418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL20477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="131" mass="14165" checksum="CA06CCD210FB0E34" modified="2015-09-16" version="1">MSSISNTTNGTQFTQPAQCANSSDAVPAMASNVQYYNQVPLYQTKDHYRDMKAVLQSCCPNTVWITEDPDACTAVCDSKTSAEAEKVMYCLNAEKVVHGTKRDKSSGAVSRPAVGWVSLMIGGMLLFGMVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2K8</accession>
    <name>A0A0G4P2K8_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Altered inheritance of mitochondria protein 24, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S004g000498</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM24 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P2K8"/>
    <dbReference type="STRING" id="1429867.A0A0G4P2K8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="entry name" value="Mitochondrial biogenesis AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00266">
        <property type="entry name" value="TIGR00266 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43657:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43657">
        <property type="entry name" value="TRYPTOPHAN RNA-BINDING ATTENUATOR PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="TRAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL20557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="342" mass="36702" checksum="64E525BD86487F51" modified="2015-09-16" version="1">MSQQHEYPPPPMSAFTPPNQPYFAQPPRQTPPLNGGYPVSPPPNKHAYSNGGYPAPPSASPPPRDPIAERNQAALLQNQSLGRLSIASQTPPAVTMEKIPGGAPAYGKFVGVQSNNADDVGTFNGGSYRISHRDTNSILTVQLAMGCPLTARPGAMISMSPTITLRGSISFSFKKFIIGGSMTMSHYTGPGELLLAPPMLGDIIVHEINRGDKWNVGRDSFLAHTSGVHHEYKPQGLSKGFFSGEGFFIYEFTGQGLFWLQSFGAIIKKDLVEGEAYFIDNGHLVAWNCEYDIERVASGGLLSSFSSGEGLACKFKGPGTVYLQTRNLNAFAAQMKISTASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P4T6</accession>
    <name>A0A0G4P4T6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S005g000476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P4T6"/>
    <dbReference type="STRING" id="1429867.A0A0G4P4T6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053008">
        <property type="entry name" value="Phomopsin_biosynth_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL21312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="199" mass="22704" checksum="0C0A5459D08E4FE3" modified="2015-09-16" version="1">MPNMESNLEFGESLLKASPREKVQKASKIKPTAIFIIIVVLVSLNVLVANLLYTPPPYKISTSPTAHCGSSRDEAKSAGCHFDPMSFSWLPTDCYDAELTKSFLGLKEWQWFTDADGSPAQHELVLRGDYDELFVSWEYHLLHCTYTWRKMHRALLRGTPVDNYIGKYNHTAHCEMMLLAQHMERNSTNTIIQTKFVSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5E9</accession>
    <name>A0A0G4P5E9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase superfamily, zinc-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S006g000072</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P5E9"/>
    <dbReference type="STRING" id="1429867.A0A0G4P5E9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="14"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL21532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="345" mass="36203" checksum="AD4CE639511E9094" modified="2015-09-16" version="1">MTNMNRSLWQDEAGVPGVIRESPIPSQIADEQIVVKVHVWAMNPADAVVQDIPLPFIKYPLILGEDIAGTVESVGSAAAAKFQPGDRVLGLALGAAVAKPEQGAFQNYVILDYSMACKIPDSMSFTDASVFPLCIATAAYGLFSKDYLGLPFPTISTAPNSTGKSILIWGGSSGVGSNAIQLCKAAGFEVLTTCSAHNAEYVKGLGADKVFYYTDADAIDQVVVELDKGECIGIFQAAGEPGPSCQVAYKSRQTLRVATSNPVPEGTVPEGVEAKMIFASGGAVIYYEINKATFAGYLPEALAQGTYQVAPAPEIVSTEGLEGIQEALDLLKKGVSAKKLVVVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6D1</accession>
    <name>A0A0G4P6D1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S006g000418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P6D1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL21878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="394" mass="43907" checksum="5BD8AB7E8F14D8A2" modified="2015-09-16" version="1">MDGDQRMKQNERSMSRSGNAARRAPGRATDSFDPAIQPRGDQTGMSQPPEQVPMSYDYGYTGSSFHGGSLQSNDLQNYQPQDYVRAQRPQQAPAIQQRRRAQPQDPAAFSPYDSTMLYGFGQQGPTQGQFEVVPQYPTRQSAAIDVLSNQFAVPQYFAPEESAGSGVAGLSPYLNAQLQPYNQPGPMARPNTTQSFPAPISDFTAIGSGSMNRLDQPQTESQQQESDQPSLEGAIGRYQRILRRTFDQTRAGRLVEAGGSLIEISEWLVTNARDLGLLHDDSIQYSDRLKLWSEFNICWLALCQKQKDLIMEVIATSQQPAHTSLIRRDRMETMGKDLIQLCDQLEPHGLVDYQMGIWEEEILSVLGQCLDLMDSSPDLHHIPARPEATAVPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6L7</accession>
    <name>A0A0G4P6L7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein family UPF0157</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S006g000394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P6L7"/>
    <dbReference type="STRING" id="1429867.A0A0G4P6L7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007344">
        <property type="entry name" value="GrpB/CoaE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34822">
        <property type="entry name" value="GRPB DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G01530)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34822:SF1">
        <property type="entry name" value="GRPB FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04229">
        <property type="entry name" value="GrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL21854.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="204" mass="23392" checksum="500D30F698650CAB" modified="2015-09-16" version="1">MPVTVAQILAPYEYKPEQVERVAQRTVQPPITIVEPNPEWPQRFEEVKARIQKAIGPLVLEVTHSGSTGVPGLPAKDVIDVDLTIKDATDEASYVKPLEEAGFRFLLREPLWHQHRFFVEDWPGAYHVNLHVWGPDSPEATRHRIFRDWLLKTPSDLELYAKVKREAAEQAAIAGDSMMDYTLRKDETIHEILARAFRDLGYIE</sequence>
</entry>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL22108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="63" mass="7245" checksum="C9BD2BF66BD285E2" modified="2015-09-16" version="1">MLEDNPKDYSKHYFGDDIQANSDVQIWSPSQWLLRFISQQGTNRDSISNIHALAVMAFRSGFP</sequence>
</entry>
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    <accession>A0A0G4P762</accession>
    <name>A0A0G4P762_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MAP Kinase Interacting Kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S007g000080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1429867.A0A0G4P762"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="STKc_MAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Meiosis induction protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Serine threonine-protein kinase mak"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="MAPK"/>
    </dbReference>
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        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
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        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="7" id="KW-0418">Kinase</keyword>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="23"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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        </location>
    </feature>
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        <location>
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            <end position="510"/>
        </location>
    </feature>
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            <end position="659"/>
        </location>
    </feature>
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        <location>
            <begin position="673"/>
            <end position="744"/>
        </location>
    </feature>
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        <location>
            <begin position="377"/>
            <end position="392"/>
        </location>
    </feature>
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        <location>
            <begin position="475"/>
            <end position="489"/>
        </location>
    </feature>
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        <location>
            <begin position="495"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
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            <end position="635"/>
        </location>
    </feature>
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            <end position="723"/>
        </location>
    </feature>
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        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL22099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="763" mass="84375" checksum="F3B528FEFAF42287" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7E7</accession>
    <name>A0A0G4P7E7_PENC3</name>
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        <submittedName>
            <fullName evidence="2">Dimeric alpha-beta barrel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S007g000244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR38052:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38052">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dimeric alpha+beta barrel"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="5"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL22263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="102" mass="12125" checksum="1D71ACC58B7BD413" modified="2015-09-16" version="1">MVYTIVVHLRAKPDEESISKLKAKLVEASNVYSNDKETLSWFVMQSVFDKQDFTIVERYVQESSQEYHLNNPYWKTFDPYVIPLLEKDMDMHRLEELEGSTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7W6</accession>
    <name>A0A0G4P7W6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S007g000368</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFB7 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4P7W6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008698">
        <property type="entry name" value="NDUB7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900">
        <property type="entry name" value="NADH:UBIQUINONE OXIDOREDUCTASE B18-LIKE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05676">
        <property type="entry name" value="NDUF_B7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="13" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL22387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="92" mass="10749" checksum="17FFD9A6FD7B9961" modified="2015-09-16" version="1">MTVIESVKSAVGLSETSATRQEMSEARVPMQYRDSCAHLLIPLNRCRQAEYYLPWKCEDERHSYEKCQYEEFKKRVAKMDELRAAKDGARSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P843</accession>
    <name>A0A0G4P843_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S007g000456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P843"/>
    <dbReference type="STRING" id="1429867.A0A0G4P843"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL22475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="363" mass="41993" checksum="F945C9FFF40E882B" modified="2015-09-16" version="1">MDTTKSNPKRQKSHEDPPPLEHQQKKGKMSVCTPGQKSDNALHTQSEFLEMRRMIEAGMFTWSGPGNKKGMKHALGFTVFVQPFLIENAKSNPEDVDLLSESQKKTIISSLAGYCVQEKWDVLMGLVPDMLRGTILEIFLEALIYKDIFGRFFMAPFWYLDGKMSPSDEGDEMFSTRLQHLYDRFYETNPLMAALWRSETNRLANSMTLDLAPSTLLGTHHRDRRQSFIGQFVDETLSSEPIKWLLRDPSSKEEEDKRYELLYMIYERAAEEAAKMGNIRGHIDFHTLAQLPETFTLGEADRMYLHEYNLCDYSDRVDGHRVLILVRPGIVRRYISAREEELTEFSMPAYVVVQESAEENKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P8B9</accession>
    <name>A0A0G4P8B9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S007g000547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P8B9"/>
    <dbReference type="STRING" id="1429867.A0A0G4P8B9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF54">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="105"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL22566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="323" mass="37348" checksum="1F06EAA21CF9264C" modified="2015-09-16" version="1">MVPRECGVSINRERIPLTPPMIPKSPNFDAKDSQVFNKFANLPSPEEVRAQAKAQYLAGVSVDNRKTFSSFGPYVRPPPAVFEDLGLFVKWGSAVSVSEGQCLYAIAQLLKDHVPIPEVYGWRQEGDEIFIYMEYLQAQTLEQAWDMLESDDRVSVCNELRIICNNLRQLEQDPADPFIGNIIRAPLYDRAFHVESMSEAGPFDTVQKFHDWFTFLYRKPMPDPYSVPIEPFRKDLPDDCAITFTHGDLHRSNILITRSKPYRVHAIVDWEQSGWLPEYWEVRKAQYTVPRNDEWSTIYLPMVLCQFAGTWDPWDYYTTAMGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P948</accession>
    <name>A0A0G4P948_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Guanine nucleotide binding protein (G-protein), alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S008g000256</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P948"/>
    <dbReference type="STRING" id="1429867.A0A0G4P948"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010255">
        <property type="term" value="P:glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000007">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000181">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF369">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-2 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="46"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="154"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="179"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="204"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="273"/>
            <end position="276"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL22827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="356" mass="41029" checksum="941E129464CEEACE" modified="2015-09-16" version="1">MGSCFSSESAGDAEQKKRSQQIDRKLEEDSRRLRRECKILLLGSGESGKSTIVKQMKIIHQNGYTVEELALYRLTVYKNLLDCAKALIGAYHYLQLEPSSQKVQDYISFLEEYNVDPDPNTSLDSKIGDAITYLWNDPCTSTVLEHQNEFYLMDSAPYFFEEAKRITAPDYVPDVSDVLRARTKTTGIYETRFTMGQLSIHMFDVGGQRSERKKWIHCFENVTSIIFCVALSEYDQVLLEESNQNRMMESLVLFDSVVNSRWFMRTSIILFLNKVDLFRLKLPRSPLSNYFPDYSGGNDVHRAAKYLLWRFNQVNRAHLNLYPHLTQATDTSNIRLVFAAVKETILQNALKDSGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P9A6</accession>
    <name>A0A0G4P9A6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LSM2-LSM8 complex subunit LSM8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LSM8</name>
        <name evidence="12" type="ORF">PCAMFM013_S008g000314</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P9A6"/>
    <dbReference type="STRING" id="1429867.A0A0G4P9A6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01727">
        <property type="entry name" value="LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000027">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034103">
        <property type="entry name" value="Lsm8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF9">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL22885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="108" mass="12133" checksum="BC84BC8E7990CDDA" modified="2015-09-16" version="1">MSLHFYVNNQVLTNLHRTEKVLILTVDGRTLIGDLLSTDQTTNLVLANTVERIIRAPDDDEPSVEIEHGLYLIRGDNVVVCGEIDEKMDGDIDWSKVRGEAIRDTKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P9A7</accession>
    <name>A0A0G4P9A7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S008g000293</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P9A7"/>
    <dbReference type="STRING" id="1429867.A0A0G4P9A7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL22864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="203" mass="23168" checksum="CB3B57928C323EAD" modified="2015-09-16" version="1">MGIWKRDKGQNQTQRFPLEAAEAFEPEDDLHRQSQRTGSPPANLLCLFPDAAPGTTLNQFRFQLHRENGVQPGLVGYLEKYVGAAHLVWSMCALLADSGIDPDWKDTFEVWRPQWRQFATSFEIQGNTSRTLDVPPSPVSIMCIQAPNSLDTYKLYAVNHKEKKRDQDALEDLWRWMLDVPPEAIVNGVYIIKLGVEPWFPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P9C7</accession>
    <name>A0A0G4P9C7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S008g000313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P9C7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL22884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="366" mass="41765" checksum="BC2F7D01FA9ADE25" modified="2015-09-16" version="1">MWLYRGAQSAVFYYATCTPCAENFDRRKRRKDASRVQREKEKERRNNEVITDQPRPFAQPTPFSTNVGWREEISLGPGPPARRGGHRNVQRTDSWNTDQSSQLKKDKSAGLMHPLGEKWKSMRYQREDEPLWGQQEVRGSSIGFSGRGRADPNETSKYYIPRVPPVNDLHPPIVSGPCSRAETRWMLQPPPSARVMAGKADVSSVTSPTSDDFTFRGFGTASRAPKNVTRENNTGRISEEADDGAIDDTTQNHRPRRPSLTQLRIDSDSPDPESHSRTDSMFSTANSDDPSLEWKYPDTPASRPQSKATDDIDKFYRPQISKTLSTMHRDNKNVHMLHLEINDDNRDEIGLGQLQPIRPWRWSMDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAA7</accession>
    <name>A0A0G4PAA7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S009g000182</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PAA7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF70">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="54"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL23242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="505" mass="56666" checksum="E0D2E00F5074BB00" modified="2015-09-16" version="1">MGEHEIQAAAVPQGEKTMRDKGCDDAAEMFNGDLVLEYSEREESIVRWKLDLSLVPMMLISYLLSFVDKGILSTAAVYGLRTDLRLEGQQYSWSNSIFYFGFLIWQYPNSIFMQRLPIGRWIGSMVFLWGVCVVATAGVTNFATLAVARFFLGVFEASNNPVFTLLVSQYYTTQEHALRACLWWAGGPIAAFIGDGVSNGIGHFHGALGRWQYLYLIFGPITMAWGIFLFFAMPSSPMTAWFLTPRERQIAVVRVLQNHTGMKNRQYKKYQVIECFRDPQVLMLFAIVFLQCIPGGGLTAFNKIILTGLGYSSVESTVVAMPEHAIQLVSVLLAGGICSYIGKGRCIAMILSNICVLVGSVLLYTLPTERKMSRLGAVYSLLTCTVSYIMCMSMISSNVAGFTKKMTASVMIFVGYCVGQIITPQFFISSEAPTYPTGFRAYFVTASMMIVIEAALMMYYLNENRRRDKRSEATVVADEGNQHHILETDLMDLTDREQPNFRYTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PB27</accession>
    <name>A0A0G4PB27_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S009g000468</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PB27"/>
    <dbReference type="STRING" id="1429867.A0A0G4PB27"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11059">
        <property type="entry name" value="CYP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF96">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE STCB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL23528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="485" mass="54604" checksum="04F3835494B75FBF" modified="2015-09-16" version="1">MPVRAAIFVGLRGTKHRADLAVRATSPLAQIPGPAISKWTDLVYIHYWFAGKAPNYVHKLHENYGPIVRTGPNRVDICTVDAVKEIHKTNSRFLKSPWYRTLIPNNMETIFSTTDPNFHSARRRLLASPISDTSLHQHEELITGRVKMTISKMGEEIQTRGATDVFKWWLFMATDIIGELSFGESFRMLEAGEKSQYILDLEAVSALQPIRTTFPNLVLCGKYLPLPVFKRAVAIGKRMRIYGTQSIERYKKILAENPSNPKKTLFTKLFDTEKGGLTDDEIQKEAQAYIVAGSDTTAVTLTYLIYAVCGNRRIRDKLVAEVTALSKPIHDNDLRNLPYLNMVISETLRIHTAVPFGLPRAVPSEGASFNGYFLPSGATVSTQSYSLHRDATIFPDPYTFNPERWENPTKEMKDISIPFGGGSRICIGLHLARMELRLGSVLFFRQFPNAQPSNKEGMSANDMEMQSFFLMAPKGHRCLIDVDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBB0</accession>
    <name>A0A0G4PBB0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prefoldin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S010g000039</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PBB0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PBB0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23164">
        <property type="entry name" value="Prefoldin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL23601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="121" mass="13677" checksum="D2BA745DFBFC3BD0" modified="2015-09-16" version="1">MSIPNEALQKLLQEIEARAIASQQQISITKAHMTAKHRDIRMLQLTSKELSELPSETNVYEGVGKMFVNVPINTVNKRLTRESGEATAEISNLEKKLQYHETTNQKSRENLEQILKSGGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBI4</accession>
    <name>A0A0G4PBI4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S010g000126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PBI4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL23688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="81" mass="9200" checksum="A1C264F9F84298E1" modified="2015-09-16" version="1">MSDQMAPKYIVTFRDSAATEEINSYVHQIQAEGGLVTNRFPDMIARGFSKRRQPGPQFKFEPRGTFEPWERLSHNLGGPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBL9</accession>
    <name>A0A0G4PBL9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S010g000156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PBL9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL23718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="107" mass="12542" checksum="ED9C4D28E16832D3" modified="2015-09-16" version="1">MGQVFKGPIDLRYAGFKSHLHRHQSCGHERGVQGRFQYSVGSVLGELKVPRFSERRIRNAYLNELQLRTTCPIDSSEKWWDTTYVLYDLAEPPSKTDWYVDSSEWEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBT4</accession>
    <name>A0A0G4PBT4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase-16, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S010g000229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PBT4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PBT4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF132">
        <property type="entry name" value="PROTEIN-LYSINE METHYLTRANSFERASE C42C1.13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL23791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="356" mass="39135" checksum="2346B4A600742E69" modified="2015-09-16" version="1">MVYYVRFLKTPRIQQQKGSIYLSALICITTDLGDSFLAEDVDLMLIAENSSGVTFQKKTKWNASNRELAITLGPLPSNLAQQSMVLTVKVPHPPGYSIPQYPPIPLVVAATSAPFGPQSTPAEKLVQRHIQYSGRAALPITIWEETGNSIARHIWDAGLATVTYLHMICENIKKKNKGTEPKIPALNRVLSNARNTPLQVVELGAGCGIAGIALASMLSNCSVLLTDLPEVEDIITRNINAAQLATMSSLQYQNLDWDDPPDELCPRPIELILVSDCTYNADSLPALVSTLDRLVRTSPEAIILVALKRRHDSETAFFDLMQSAGFTAVQDSVEIPSQHEEVDEIEFYCYSRPTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCK9</accession>
    <name>A0A0G4PCK9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S011g000059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PCK9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PCK9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025255">
        <property type="entry name" value="DUF4202"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41729">
        <property type="entry name" value="GLUTAMYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41729:SF1">
        <property type="entry name" value="GLUTAMYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13875">
        <property type="entry name" value="DUF4202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL24065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="195" mass="21961" checksum="E759905ADF913D66" modified="2015-09-16" version="1">MTKYETALERIDAAHADDPREAQTSTGPIPYELHYAQKMTNYLSTLNPSAPELLRLAIRAQHLRRWEVPRDSYPATKIGYHSWRAGLQRRQAALVEQICVESGYSTEEAARVGALVRKADLKQGDPDTQTLEDVACLVFLDDQFDKFEAELADEGKMVDILRKTWGKMSERGREEALKIQLSDKAKKLVGIALSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PD96</accession>
    <name>A0A0G4PD96_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Crh-like protein</fullName>
            <ecNumber evidence="19">3.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">PCAMFM013_S011g000218</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Dual chitinase/transglycosylase that plays a role in cell wall architecture. Chitinase and transglycosylase activities are coupled. Required for the polysaccharide cross-linking at the septa and the cell wall. More specifically, transfers chitin to 1,6-beta-glucan in the cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.-.-" evidence="19"/>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A0G4PD96"/>
    <dbReference type="STRING" id="1429867.A0A0G4PD96"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:side of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:carbohydrate binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:endochitinase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:glycosyltransferase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cell wall glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
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        <property type="entry name" value="GLYCOSIDASE CRH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="16" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12 21" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="10 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="25" id="KW-0430">Lectin</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11 19 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 23" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195576" description="Crh-like protein" evidence="23">
        <location>
            <begin position="20"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="24">
        <location>
            <begin position="21"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="20">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="20">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="25"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00093308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR037299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-1"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="CRL24224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="366" mass="39227" checksum="344C36E35557A7FB" modified="2015-09-16" version="1">MRFILGAALSLLSSTLVVAQTYTDCNPTQKTCPADPAFGQSDKTFDFTSGASDAFKSTGSVTYDQTNGATFTIAKQGDGPLIQSGWYIMFGRVECTIKAAAGTGIVSSAVLQSDDLDEIDWEWLGGNNAQVQTNYFGKGDTSSFSRGAYHDNSGNHDDFHTFSIDWTSSQIVWSIDGKTVRVLTPETAETNQYPQSPMMVKVGVWAGGDPNNAKGTIDWAGGQTDYTQGPFKMYMKSMTVTDYSTGTSYRYGDKSGSWQSIVAEGGTVNGNKAAEPTSTESAPAITATVDSVPVPWSGTHKETSSWVTPNVWPWVATGSPLASSTGYDWESGSGQNMPPGGGSMIYLPLYVSSVAFFFGCLFPLWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDS4</accession>
    <name>A0A0G4PDS4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA repair metallo-beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S012g000056</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.</text>
    </comment>
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        <property type="protein sequence ID" value="CRL24447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16273">
        <property type="entry name" value="SNM1A-1C-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA cross-link repair 1A protein, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA cross-link repair protein pso2/snm1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011084">
        <property type="entry name" value="DRMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF6">
        <property type="entry name" value="DNA CROSS-LINK REPAIR 1A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07522">
        <property type="entry name" value="DRMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA repair metallo-beta-lactamase" evidence="7">
        <location>
            <begin position="685"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL24447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="845" mass="92873" checksum="E6D456FBB31EF0C0" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDT6</accession>
    <name>A0A0G4PDT6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S012g000060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PDT6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PDT6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL24451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="109" mass="12105" checksum="D99A301BDE504F4B" modified="2015-09-16" version="1">MLILLTEYYVDVKDLARLHAIALLDPSVKSERIFGLAAPLIWKEVIDHLRELRPASSDKLVKNPPGAREGYVDIVAPTRSKELLNSFFGQADWTPLKESLYAGITSAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PEG8</accession>
    <name>A0A0G4PEG8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S012g000338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PEG8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL24728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="330" mass="35702" checksum="3AF240A9EC00FD4B" modified="2015-09-16" version="1">MGKPTTLDIEYASLMARNPEGTFLYIPPTFKKFHPGSVGFFDDNGGWNQITDLGKEGQSKTDGFTTLGRTLSRDEPTASMWKTRSSESEDGNHVRLSGGLSAAAAAAVPIDVTGDGKHKNSASGKAGLVTGSLVKREKILAPFGKPVSKWASENAKALLASDFSTDIEKNGLWIIQSAWVTDECAIHMTNSKDKEIDVGLDIAATGVGSVGGGGGTFEKLRNEGWTTYQAQEGDEGLVVSFSGSHYKPRMFQRFRSDPLKQSTADSYLRGGGELVNEFDFEVERIGVSNSDLEEEEAAEKKEEEKIRAELEAKKIAILRNTSVTHEVVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PEQ9</accession>
    <name>A0A0G4PEQ9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S012g000351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PEQ9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL24741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="218" mass="24226" checksum="04C1A41CAD6B6334" modified="2015-09-16" version="1">MGCKSSVPVRPQVLPEITVALVWVSQQEIEALVNATETLEITRREPGMKFTTTPTTTDAATTLPTDEPEEKEADPTAEQTRQGQVYHIQTKTLDRPVNYTSQICLIVMPFGLQFVGTGGYDVAPGLQFVAHHAVVISLDLVPVLPRRLLRKIYVGEDAATSATESLRHVLAGVDQFAFWECGLEELVLWWLSLLRQYWFPIACVVVLVLILILVIVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PFD4</accession>
    <name>A0A0G4PFD4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine cleavage system P protein</fullName>
            <ecNumber evidence="7">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S013g000287</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GcvP family.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="7"/>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL25044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PFD4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PFD4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016594">
        <property type="term" value="F:glycine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000005">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000007">
        <property type="entry name" value="glycine dehydrogenase (Decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000007">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049316">
        <property type="entry name" value="GDC-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049315">
        <property type="entry name" value="GDC-P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003346">
        <property type="entry name" value="PRK04366.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773:SF1">
        <property type="entry name" value="GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="GLYCINE DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21478">
        <property type="entry name" value="GcvP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="8">
        <location>
            <begin position="75"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="8">
        <location>
            <begin position="567"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="878"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL25044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1057" mass="115180" checksum="C3F2522F24040EAA" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PFY6</accession>
    <name>A0A0G4PFY6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bactericidal permeability-increasing protein, alpha/beta domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S014g000108</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PFY6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PFY6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045967">
        <property type="entry name" value="HAM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138:SF4">
        <property type="entry name" value="DUF5923 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19343">
        <property type="entry name" value="HAM1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAM1-like N-terminal" evidence="2">
        <location>
            <begin position="186"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL25212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="733" mass="83312" checksum="2DBCEA6F2526A05A" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PG30</accession>
    <name>A0A0G4PG30_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear cap-binding protein subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">20 kDa nuclear cap-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S014g000174</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RRM NCBP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PG30"/>
    <dbReference type="STRING" id="1429867.A0A0G4PG30"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12240">
        <property type="entry name" value="RRM_NCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000399">
        <property type="entry name" value="Nuclear cap-binding protein subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027157">
        <property type="entry name" value="NCBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034148">
        <property type="entry name" value="NCBP2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847">
        <property type="entry name" value="20 KD NUCLEAR CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="50"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="131"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL25278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="178" mass="20796" checksum="9620182F7A7CD8D4" modified="2015-09-16" version="1">MSLLAVNTVDRLDRPSAYYVSKNKRRRFNDREEDEPQQQEKPDDKLKNATTLYVGNLSFYTTEEQIHELFAKCGEIKRLVMGLDRFNKTPCGFCFVEYYTHQDALDCLKYIGGTKLDERIIRTDLDPGFEEGRQFGRGKSGGQVRDEYREEYDPGRGGYGRAYDEQRQREEDEYGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PH40</accession>
    <name>A0A0G4PH40_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S015g000247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793148">
        <property type="protein sequence ID" value="CRL25661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PH40"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37844">
        <property type="entry name" value="SER/THR PROTEIN PHOSPHATASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_1G14840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37844:SF2">
        <property type="entry name" value="SER_THR PROTEIN PHOSPHATASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_1G14840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL25661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="257" mass="29835" checksum="55136FCA9BB93EA8" modified="2015-09-16" version="1">MPVHVLSDIHLEINQQYSFAIPVCSKYLTLAGDIGRLEDYNKYRDFLQNQTSKFEIVFLALGNHEFYETTFNSGLEKAKQLEKEPCMNGRLVILHQRRYDIPDSGVAILGCTLWSQIPQESTDIVHYKISDFQKIKQWSVEQHNKAHEADLTWLKGEIQTLRETSQEKRSVLVVTHHAPSLQRTSSPQHAKNPWSCAFGTDLLAQSWDGVRVWVFGRTHYTTEFKKKGIRVVSNQRGYVLPWKTEEGNFDVRRVVWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PHA3</accession>
    <name>A0A0G4PHA3_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">nitrilase</fullName>
            <ecNumber evidence="4">3.5.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S016g000003</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a nitrile + 2 H2O = a carboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18379"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="EC" id="3.5.5.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.5.1" evidence="4"/>
    <dbReference type="EMBL" id="HG793149">
        <property type="protein sequence ID" value="CRL25722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PHA3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PHA3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000257">
        <property type="term" value="F:nitrilase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07564">
        <property type="entry name" value="nitrilases_CHs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000132">
        <property type="entry name" value="Nitrilase/CN_hydratase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF14">
        <property type="entry name" value="ARYLACETONITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00920">
        <property type="entry name" value="NITRIL_CHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00921">
        <property type="entry name" value="NITRIL_CHT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CN hydrolase" evidence="6">
        <location>
            <begin position="9"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00036406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL25722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="328" mass="36804" checksum="8A37D42594EB0122" modified="2015-09-16" version="1">MTAPVERTVRVAAVQAEPVWNDLQGGVEKVISLLGDAGKEGANVVGFPEVFIPGYPWSMFTTSALDNGPFMDEYFHNSLAVDSDEMRRIQVAVKENGTFCVLGFSERYRGSLYISQVFINIDGQIVHHRRKTKPTHVERAYWGTGEGDSLKTVVDSPFGRIGGLNCWEHTQPLLRYYEYQQDVDIHVASWPAIWDRPESFGSKMPYWITSDINRKMSQAMAFEGACFVLVCTQVMSEENFNKNKVQDLEYVQGTGGGFSAIFGPGGEPIATMPSDKEGILYANVDVNDKLRAKQWLDVVGHYSRPDMLSLRVNTHPSKPVFFAEEPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PI91</accession>
    <name>A0A0G4PI91_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cutinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S017g000032</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793150">
        <property type="protein sequence ID" value="CRL26049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PI91"/>
    <dbReference type="STRING" id="1429867.A0A0G4PI91"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630:SF9">
        <property type="entry name" value="CUTINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="CUTINASE RV1984C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195374" evidence="3">
        <location>
            <begin position="25"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL26049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="241" mass="26203" checksum="9F65F2F6F724AED4" modified="2015-09-16" version="1">MYDMAVKIVWALSAVTLMLIQTNAQSVSKDECATSVHAIIARGQGGGDDLNVMSTLSDLILKQIPGSTTLGLPYDHQNVLTDYAKLHTVHDGAVLMQQFVQEYSESCPQTKIVVVGYSMGAVLMMDSLCGTSEVGFFFVAPLARSYNSTIIAAIAYGDETYIPGMPWNVGNCALGIGLLPRFNSALCGPFASSIRSYCDYGDEQCCSPYPPDGNAAHHHYIWKYNQDVVDFIKHRLATIGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PIC4</accession>
    <name>A0A0G4PIC4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Amine oxidase</fullName>
            <ecNumber evidence="11">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S017g000067</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="11">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="10">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10 11">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="11"/>
    <dbReference type="EMBL" id="HG793150">
        <property type="protein sequence ID" value="CRL26084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PIC4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PIC4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000011">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000017">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF60">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="12">
        <location>
            <begin position="240"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="9">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="10">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL26084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="679" mass="77222" checksum="B922C2E1CA65286C" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJA4</accession>
    <name>A0A0G4PJA4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S018g000175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJA4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJA4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL26482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="261" mass="29628" checksum="D94A052DE6BDD9B1" modified="2015-09-16" version="1">MPPLTNSPKAWKSWWVRLYKLSTASDISTIELKEFINEPPVEPKLPKIPAMAMDSAGINESFGLSEVQGHETWQIPRPLILIRPDFETWLNIASKPAEAPSGYKIDALLFRICENLTTNGLLDGPKVTCTHHFEISLEWGPITYHNKQYKCVGTADYGIFFGEQDHMAYHLIVLDAEQNHQGQLLACMAMVRAKRKAHGEPDSTVWGVLTDGQWFYFSRLNNEGKWSIVAYRLRRDGRGDIVNVMAYMVLQGHRNAVSALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJJ9</accession>
    <name>A0A0G4PJJ9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S018g000029</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJJ9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL26336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="284" mass="31853" checksum="27DE9848458A0F05" modified="2015-09-16" version="1">MPWPWCFPFKQDQSKIAKTSPLPPDEETGLKLLYDGLTPKVDIIAVHGLNGHRENSWTAANGVNWLHDLLPGDMPNIRVLSWGYSLTTVGNSNEKISQQQVSEQLVYDLWEMRSSTNTVNRPIIFIAHSLGGPIVKSALLYADSTQETSTTDLRSIRLSTRGAIFMGTPELDSRLIGLQSYLANAKGSEQESSDIYKEAHWLVTILQGYPSISQQFWTLFVHERLGSLPTNSTLDQTASFSPQDNSSHIFIQADHGGMIKFESSLDQGYLKIKEHLVYVEKMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJL1</accession>
    <name>A0A0G4PJL1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aromatic-ring hydroxylase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S018g000026</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJL1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJL1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="12"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="280"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL26333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="411" mass="46655" checksum="FD26EB39E5A3D0E0" modified="2015-09-16" version="1">MSHQNWRPGKRVAISGGGPGGVSTALAFIQRGFDVRIFERQPECKPTGGAVLLNLPVMAVLRSYGMSIENMGPPTTTSIQNKYGVERVEIPFNEEIERRIGIKGWQYGALRSSLMKKMLDLLPLGVVHTRHELVAYTDLPGEDGLELEFKNGRKITADILIGADGIHSAVSRQAFGDPNLFHAGIRVWLSWCDKIPDIPENDAVISHDWQYQASYFPLLHEGKPCFEWWVVEPSWEGKPMPEDPKAYLSGVLKDWSGPMSRFMEITDFDTQVYQWEIYNRPSMKKWSTGRVVCVGDAVHPVSPYAGYGLGMAIEDGYFLAKFLDGVDLRNLAAVSAGFELYEKQRVEYVNHNMEVARFSGKLFHSFPWPIAKVRDWLFDYTPLLGYMMKKDYLKKAEEHSMSIKELHVIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJT4</accession>
    <name>A0A0G4PJT4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S019g000035</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJT4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJT4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03273">
        <property type="entry name" value="ABC_SMC2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1060.20:FF:000005">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000278">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000385">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1620:FF:000006">
        <property type="entry name" value="Structural maintenance of chromosomes protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="233"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="534"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL26935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="677" mass="74726" checksum="B0788086A0057791" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKS9</accession>
    <name>A0A0G4PKS9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S019g000218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKS9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PKS9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL26801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="395" mass="45475" checksum="D685744A0651D5D2" modified="2015-09-16" version="1">MVLRHPNASTTGVNPPLVCLLCGMEVPATCDSGITDICEHGQIHDQIPKQSQWKGIWKSNLDHVVVPSHEIEEAYFSDFPRLWACFCRVIIKESDTKYRLTGINIARHHAGYPYYTPNDPAMARIGGRKGPDNQPVGGRRINQYDDPGFTQFYAANIGRQPSQYKGKLLGYLIHAHCWVLFGRVEGLKLKEAKLAKLVQVCRNYWRNNKLWRLNDYNVQFIKPRQVLSEFEYGFDIYQNPLVVPEVQKAMNCAPVESLRESRSRHLPSHLNSIPLEVAALIAEWVCPVKYTLDDIKNTGNMLLVFEWKLPEWFWKGRLDERSFIELDKPKKARSPVSWQLRLNLMCLVVDRTRFSSNGLASRERVLGVLLDLENAYLNQAKTSQGERLRRKEIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PL10</accession>
    <name>A0A0G4PL10_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S021g000030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793154">
        <property type="protein sequence ID" value="CRL27115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PL10"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL27115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="110" mass="12155" checksum="43F2AAC7890109B7" modified="2015-09-16" version="1">MSLLVGILERLSKSSTSMQSSLAQTSRAQYLHSSVTRSLPIALRPSHLCGRLLQSGCCRWLSTAVTCRRCSSGCVSAKLLSAAFLETGTRWCRRRERTDSALYMRSVTNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PL51</accession>
    <name>A0A0G4PL51_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S021g000009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793154">
        <property type="protein sequence ID" value="CRL27094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PL51"/>
    <dbReference type="STRING" id="1429867.A0A0G4PL51"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195441" evidence="1">
        <location>
            <begin position="19"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL27094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="111" mass="11565" checksum="84774F3B6758745D" modified="2015-09-16" version="1">MKFTSVVVAVMAAATVQAAATGQSTTLPKWCGHVGQGCKRTADASVDVKRSADALAEAMAKNLPLVLQKWCGHIGQGCYKAKRAADAADEVKRTSDALAAAMAALEEEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-11-27" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PL63</accession>
    <name>A0A0G4PL63_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">UDP-N-acetylglucosamine transferase subunit ALG14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Asparagine-linked glycosylation protein 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ALG14</name>
        <name evidence="12" type="ORF">PCAMFM013_S021g000085</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">Heterodimer with ALG13 to form a functional enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ALG14 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793154">
        <property type="protein sequence ID" value="CRL27170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PL63"/>
    <dbReference type="STRING" id="1429867.A0A0G4PL63"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043541">
        <property type="term" value="C:UDP-N-acetylglucosamine transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013969">
        <property type="entry name" value="Oligosacch_biosynth_Alg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154:SF4">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08660">
        <property type="entry name" value="Alg14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="13"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL27170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="276" mass="30759" checksum="02872513DCA4011A" modified="2015-09-16" version="1">MTFSLGSLSFWDLLLWCCVLVITLGASILLVLLISLTISQNIIPPKCRARGSPTHLLVVLGSGGHTAEMLYMLERMNFDPQIYTYRTYLVSSGDNFSADKAKDFETQHVQNSQGHAHNNNYTIVTVPRARRVHQSYLTAPFSTLQCFWACLNVLRGLHPDQKLPKEYGSLYPDLILTNGPATAVCVVAGAKLIRFFLCLAKCTASCLGLRALSSFTSVPKLRTIYIESWARVSSLSTSGVLLLPLADRFLVQWPAQAGRRAWWGMKRTQYAGWLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PL69</accession>
    <name>A0A0G4PL69_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stress-induced protein, KGG, repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S021g000092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793154">
        <property type="protein sequence ID" value="CRL27177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PL69"/>
    <dbReference type="STRING" id="1429867.A0A0G4PL69"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019626">
        <property type="entry name" value="Stress-induced_KGG_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10685">
        <property type="entry name" value="KGG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL27177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="81" mass="8812" checksum="BA2321EDEF877B28" modified="2015-09-16" version="1">MVDNPNPGNFHNRPHEEVEQIARKGGQSSHHSGFASMDTNKQREIASKGGHASRGKFEPGSPRAKEAGRKGGRSAHQQPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PLL5</accession>
    <name>A0A0G4PLL5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S020g000197</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793153">
        <property type="protein sequence ID" value="CRL27038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PLL5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PLL5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN LPX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195783" evidence="1">
        <location>
            <begin position="19"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="52"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL27038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="292" mass="31283" checksum="564C50F93A64E175" modified="2015-09-16" version="1">MFFSSSLFLAFAAICAHALPVFTQPLANYKWPTQFVRSGEANIQVLVQGAGPTVVIIPSYGRDGGDDYNYFSNSLVEAGYLVLRPQPRGTFESTGPITNVTLEDLAADIAAVIDTLGGGEAIVIGHAFGTFLAKVSSVLYPEKIPAIVVAAPGGIDLPTDIAKMPFITGNTSLPIPERLKALQTAFFAPNHDAHIWIDGWYPDVLAMEHAAVEAYGSLASHWGGANTTQVLELIPADDPFQPKAQWNVTADLYPNRATSKVIADASHALFPEQGKAVLEAVLPWLNQQSSHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PLY1</accession>
    <name>A0A0G4PLY1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S022g000105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793155">
        <property type="protein sequence ID" value="CRL27425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PLY1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PLY1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12108">
        <property type="entry name" value="Hr-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053206">
        <property type="entry name" value="Dimeric_xanthone_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048:SF1">
        <property type="entry name" value="HEMERYTHRIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="2">
        <location>
            <begin position="30"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL27425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="177" mass="20691" checksum="64A723C77077C87C" modified="2015-09-16" version="1">MGSSKMTSSSGDSGDSPLSASDFRTYNRMSEQMEGFHSHFRLTWNQLWEACESSGKRGLSARQMIMMGLQFCSQLDFHHSIEEQHIFPVLAKKMPEFRKELELLSQHRQIHAGLEKLEKYLEKCRSGEEDMRREEVKRLMEGFGKVLWTHLDQEVQTLGAANMRKFWSLAEMRRLPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMR9</accession>
    <name>A0A0G4PMR9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase kappa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S022g000111</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793155">
        <property type="protein sequence ID" value="CRL27431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PMR9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PMR9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.810:FF:000001">
        <property type="entry name" value="DNA polymerase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.810:FF:000003">
        <property type="entry name" value="DNA polymerase kappa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000014">
        <property type="entry name" value="DNA polymerase kappa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000010">
        <property type="entry name" value="DNA-directed polymerase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000039">
        <property type="entry name" value="Polymerase (DNA directed) kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000012">
        <property type="entry name" value="Putative DNA-directed polymerase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050116">
        <property type="entry name" value="DNA_polymerase-Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024728">
        <property type="entry name" value="PolY_HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
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    </dbReference>
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        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="114"/>
            <end position="293"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
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        <location>
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            <end position="615"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00016178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL27431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="615" mass="69223" checksum="88B90314782CC919" modified="2015-09-16" version="1"> </sequence>
</entry>
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    <accession>A0A0G4PN19</accession>
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        </submittedName>
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    </gene>
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            <taxon>Penicillium</taxon>
        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CRL27548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="233" mass="26268" checksum="36AE5EB3A094F417" modified="2015-09-16" version="1">MDSVPPRKKENEDHSVFLSSVASTELFLTSRGLRTPLELPKEENSVGIPEVSLGARGLSKQNNLETTFPECQTKRAVHFKRENGSKLHRTSEKSNEIFCKRNRVRKSSQGQHGSKASQCILSGSFKNRTLSKAMKLGPITYRGALKMTGKLCKAQLPLLKNHLRDRSDLFSDGEALLHEIATAHPKYNQIIRTLPILLNFIPGELKEKLMIEENAEWLKMGAYLVNKWISRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PN47</accession>
    <name>A0A0G4PN47_PENC3</name>
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        <submittedName>
            <fullName evidence="8">Sad1/UNC-like, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S023g000056</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
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                <person name="Silar P."/>
                <person name="Lacoste S."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">FM 013</strain>
        </source>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911:SF8">
        <property type="entry name" value="KLAROID PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911">
        <property type="entry name" value="SAD1/UNC-84-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
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        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
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        <location>
            <begin position="404"/>
            <end position="658"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL27598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="658" mass="72771" checksum="7F6A622B8BA634D9" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNC6</accession>
    <name>A0A0G4PNC6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heat shock 70 kDa protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S024g000177</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the heat shock protein 70 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CRL27922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PNC6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PNC6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000028">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
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        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="604"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="605"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="627"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL27922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="636" mass="69743" checksum="4E190F6411438282" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNF1</accession>
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    </gene>
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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    <dbReference type="STRING" id="1429867.A0A0G4PNF1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL27706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="282" mass="30615" checksum="4499CCE18430767E" modified="2015-09-16" version="1">MGTQDERSIQENEGPPAYHEALSCSTTSSRYGSLPSTMSVHGQWTKWKSMNLCGGSNAKDRLCLIEMQTGYSGKAPLGMRTGFLLRKGMSTKDPLLAAAGDESRGLHAFNPDGIVFLPPLDPAPKSDRMDTELLRAEPGTNNDIAFHFSIEVGDKERREEFAWRKVKKGEDQAKRNGFKLVRLSSSQQSSQPSGSSSGQAPSSSSSLLVGKDGEIVAFLGWVMAWPSLTHAFTLEVVDGQSGALGGRWTLMVIVTAIRLYTLHVKGKTSRFVVDMGKKTSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNH1</accession>
    <name>A0A0G4PNH1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCAMFM013_S023g000184</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + H(+) = an aldehyde + CO2</text>
            <dbReference type="Rhea" id="RHEA:11628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="EC" id="4.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
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    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0000949">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF11">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="15">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="13">
        <location>
            <begin position="196"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="14">
        <location>
            <begin position="399"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CRL27726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="580" mass="63064" checksum="113B71F7F78C662A" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNW0</accession>
    <name>A0A0G4PNW0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S024g000108</name>
    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793157">
        <property type="protein sequence ID" value="CRL27853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PNW0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PNW0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL27853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="858" mass="98038" checksum="4D595D0563ACB4F8" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PP42</accession>
    <name>A0A0G4PP42_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Striatin, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S025g000021</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793158">
        <property type="protein sequence ID" value="CRL27963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PP42"/>
    <dbReference type="STRING" id="1429867.A0A0G4PP42"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013258">
        <property type="entry name" value="Striatin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051488">
        <property type="entry name" value="WD_repeat_striatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653:SF0">
        <property type="entry name" value="CONNECTOR OF KINASE TO AP-1, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653">
        <property type="entry name" value="STRIATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08232">
        <property type="entry name" value="Striatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Striatin N-terminal" evidence="6">
        <location>
            <begin position="23"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="391"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="725"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="87"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="311"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="557"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="569"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL27963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="804" mass="87640" checksum="57ECD08FE1A35976" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPE0</accession>
    <name>A0A0G4PPE0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPN-loop GTPase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S026g000120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793159">
        <property type="protein sequence ID" value="CRL28255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PPE0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PPE0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17871">
        <property type="entry name" value="GPN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000338">
        <property type="entry name" value="GPN-loop GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030231">
        <property type="entry name" value="Gpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF3">
        <property type="entry name" value="GPN-LOOP GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="298"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="327"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL28255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="357" mass="40188" checksum="FB4F2C62640F6117" modified="2015-09-16" version="1">MPFAQLVIGPPGAGKSTYCNGMHQFLGAIGRKCSVVNLDPANDKTSYPCALDVRDLVTLEDIMEEDKLGPNGGVLYALEELENNFDWLENGLKELGDDYILFDCPGQVELFTHHASLRNIFYKIQKMGIRLIVVHLVDSYTLTLPSMYISALLLSLRAMLQLDLPHLNVLTKIDNLANYAPLPFNLDYYTEVQDLTYLLPELESESSRFSHEKFGKLNQTIIDLVEEFGLVAFETLAVEDKKSMMSLLRAIDRASGYAFGPAEGANDTVWQVAVREGMGVTDVRDVQERWIDAKDQYDEQEEKDLEEEVRVRNAASQVEATGAVDGGPDEDDGHDYDEELEKWKKDMPDSGVRVHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPX2</accession>
    <name>A0A0G4PPX2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glucose-methanol-choline oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S027g000103</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793160">
        <property type="protein sequence ID" value="CRL28414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PPX2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PPX2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF152">
        <property type="entry name" value="OXIDASE (CODA), PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="265"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL28414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="542" mass="59820" checksum="FED4F4406DED1584" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQ65</accession>
    <name>A0A0G4PQ65_PENC3</name>
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        <submittedName>
            <fullName evidence="11">Beta-ketoacyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S028g000058</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049492">
        <property type="entry name" value="BD-FAE-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041068">
        <property type="entry name" value="HTH_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
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        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
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        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF21">
        <property type="entry name" value="NON-REDUCING POLYKETIDE SYNTHASE AUSA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BD-FAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18558">
        <property type="entry name" value="HTH_51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="1"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="10">
        <location>
            <begin position="863"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1209"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="7">
        <location>
            <begin position="863"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="7">
        <location>
            <begin position="1016"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="7">
        <location>
            <position position="894"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="7">
        <location>
            <position position="1074"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL28505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="2035" mass="222738" checksum="0BB49E2E1B3AC8F8" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQH6</accession>
    <name>A0A0G4PQH6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polynucleotidyl transferase, ribonuclease H fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S027g000065</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CRL28376.1"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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</entry>
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    </organism>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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                <person name="Debuchy R."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ADR321CP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
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        <location>
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            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
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        </location>
    </feature>
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        <location>
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            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
    </feature>
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        <location>
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            <end position="325"/>
        </location>
    </feature>
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        <location>
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            <end position="500"/>
        </location>
    </feature>
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        <location>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
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            <end position="608"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL29204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="614" mass="66583" checksum="668343F44BE12495" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PSL1</accession>
    <name>A0A0G4PSL1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein family UPF0057</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S035g000072</name>
    </gene>
    <organism evidence="9 10">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
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        <property type="protein sequence ID" value="CRL29377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195594" evidence="8">
        <location>
            <begin position="21"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="119"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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</entry>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="8">
        <location>
            <begin position="55"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="7">
        <location>
            <begin position="151"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="6">
        <location>
            <begin position="261"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL30405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="416" mass="46481" checksum="36DC7810173DE70C" modified="2015-09-16" version="1">MAILTYQEGCHAASDYDHYTRVRPSFFKAKIPIYPSPSERCENLSKICWDFPDSYWAQVDESHRFPTELYEALAGQGWLGICLPQRYGGSELGISEAAVMMQTIAESGGGMTGASSIHMNIFGLEPVAKFGTEEQKERWLTPLISGHHKACFGVTEPNTGLDTLQLQATARRSGDGYVLSGQKVWISTAQRADKILILVRTTPRDRVKKPSQGLSLFYTDLQVPQVQITEIPKMGRAAVDTNSLFFDNWHVPMEDRVGEENEGFRMILHGMNAERILIGAEALGLGFAALRRAALYSNDRHVFGRPIGQNQGIQHPLADSWMKLEAARMMIYQAARLYDQGYTGGEYANAGKYLAAEAAFEACERAILTHGGMGYAKEYHVERYLREVLIPRIAPVSREMILNYIGERVLGLPKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVD7</accession>
    <name>A0A0G4PVD7_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Purine nucleoside phosphorylase</fullName>
            <ecNumber evidence="7">2.4.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Inosine-guanosine phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S044g000048</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine and inosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a purine D-ribonucleoside + phosphate = a purine nucleobase + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19805"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PNP/MTAP phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="7"/>
    <dbReference type="EMBL" id="HG793177">
        <property type="protein sequence ID" value="CRL30117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PVD7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PVD7"/>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09009">
        <property type="entry name" value="PNP-EcPNPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1580:FF:000004">
        <property type="entry name" value="Purine nucleoside phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011268">
        <property type="entry name" value="Purine_phosphorylase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01697">
        <property type="entry name" value="PNPH-PUNA-XAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006054">
        <property type="entry name" value="PRK08202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904">
        <property type="entry name" value="METHYLTHIOADENOSINE/PURINE NUCLEOSIDE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904:SF9">
        <property type="entry name" value="PURINE NUCLEOSIDE PHOSPHORYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000477">
        <property type="entry name" value="PurNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="9">
        <location>
            <begin position="32"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="92"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000477-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL30117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="317" mass="34439" checksum="A9315D23661B8161" modified="2015-09-16" version="1">MTKIDLSSFERANEAVSYLRTKLPETLQKPQVAIVCGSGLGGLADTIQPESRIEFDYASIPHFPRSTVVGHAGKLVFGLLGQKIPAVLMVGRAHYYEGHSIDQVAFPIRVFKQLQVNTVVLTNAAGGLNSEYAVGDIVLLNDHLFLAGLAGTHPLRGANEDEFGVRFPPLSDAYDLELRRHVHQSWKKVISPESKRKLHEGVYAFCGGPTYETRAESRMLRMLGADVVGMSTVPEIVTARHCGLRVLAFSLVTNKAVLSPVPRGDDDLLQNKAAGELSALLEEGMAGHEEVLEAGRAAAIDMQKLVVETLVDVFDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVJ3</accession>
    <name>A0A0G4PVJ3_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Galectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S051g000011</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 L-dopa + O2 = 2 L-dopaquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:34287"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57504"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-tyrosine + O2 = L-dopaquinone + H2O</text>
            <dbReference type="Rhea" id="RHEA:18117"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosinase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793184">
        <property type="protein sequence ID" value="CRL30408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PVJ3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PVJ3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004503">
        <property type="term" value="F:tyrosinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042438">
        <property type="term" value="P:melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041640">
        <property type="entry name" value="Tyrosinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF76">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18132">
        <property type="entry name" value="Tyrosinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-0430">Lectin</keyword>
    <keyword evidence="7" id="KW-0470">Melanin biosynthesis</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Galectin" evidence="12">
        <location>
            <begin position="339"/>
            <end position="477"/>
        </location>
    </feature>
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            <end position="334"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048233"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="497" mass="56079" checksum="973A3B480695DB15" modified="2015-09-16" version="1">MGNVPVASFDPLFFLHHCNIDRLFAIWQALNPDKWMDNIPADNTTIRDSFGKEHPVNGNTPLQPFRRDAEGNYWTPEGIRFPSNLGYSYPELPRWETKYHQEDGTLNQALFKENITTIINTLYGVSRDLALDPKAPTPEGVEAIDGGLKIPDFAFSVRFLKYALGGQPFWVKLYLAQEDGIQTPLTDLIAEVYNFSQKPELDGSSVCGNCTKGQKSRVKSTAYIPITPVLYKLIRDGRKLKSLTRDEVLAYIRKRAYWRNEKELPRYDVEKLELEIIGSSNDTKHFTNPALPPAFENFKKEPTITGGADGALDPELKQAKIDPPPPRPKRPRANLPLHGSLQFQQTLKADSVILLESSSVDPVKPDDGIDMTQISIMDAENDTIFHISIRRAQGQIIFNAKIGGSWGEEERINIARRFDSEDGATILIHDQGEGFEVSIDWVHAIWFAKRAQGKAAQSIRYELGDKEGTSVLSDDLEVRTYPSMKALFLQKHAHEEK</sequence>
</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Dupont J."/>
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                <person name="Abraham A.L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="112" mass="12743" checksum="A1FA202C604F487F" modified="2015-09-16" version="1">MEPSNASDYVADLERQIYGLRQILREWTPYVPPHVLVRSQIPREITSSHLLRPPVSQPLSATKHKGVSLSGLSRLEETWKKPLENFINRIPCAEKWSGAVSLPQISILDLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PWX0</accession>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PWY9</accession>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <location>
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            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="95" mass="10839" checksum="DC747373848ACDB1" modified="2015-09-16" version="1">MERQFPTKVTSGASFKYPRQTQDQESKQLKDEEQESDAEEMGRYDKAMVTEKKELENKSHTKTWQNEKAAAAKLISTGHPVDSKTAWSSSWLQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PX27</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF47">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
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    </dbReference>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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            <end position="158"/>
        </location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="432"/>
        </location>
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        <location>
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            <end position="472"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="566"/>
        </location>
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            <begin position="141"/>
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        </location>
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        <source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL30853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="587" mass="64103" checksum="BC757A143B33526C" modified="2015-09-16" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
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                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="282" mass="31837" checksum="24E026A202072BCF" modified="2015-09-16" version="1">MPLESESSGGHAVVEVMQSSSLLASLTNLTLEDDKAPHFVDTESKIATLVGRLQGLPTKPPSLYIDLEGVNLSRHGSISIIQIYVLPFEETYLVDIHSLQEKAFSQTASDKSQTLLGILESPDTPKVFFDVRNDSDALFSHFNVKLAGVIDLQLMELATRYFPRKYVNGLGKCIERDARLTTYETRLWKASKEKGLKLFAPERGGSYDVFNVRPLSEDIKEYCVQDVQYLPRLWVQYHRKISPSWARKVITESTNRVKLSQTATYDGSGKWKALAPLGWQYM</sequence>
</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Dupont J."/>
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                <person name="Abraham A.L."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="98"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL31441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="325" mass="37311" checksum="BEC1D5371FD5067C" modified="2015-09-16" version="1">MPENTCARSCQNLAYIHSKLAQLPQRNTKKTADSSDVHKINAIPPLVALPPELLLKILGNLQDLEDFFSSILVCRRILNVLQAQRPQRQIIESTFAKYLHPKTDWGTYKVLIQLSQIIRRDIVHRDTVRHVFETGWEIFKQRHQEELLIPFGRALAWCYVLDYHRSDAICLLQLIKKGEPPFGWSTRASSQPPIQPISELLDQLVSEENGVDRMYISSDMDHPLVEINGYSKLSLNDKERAILLRNGIFFRENSIVTRKRKPCPPRASSRPMFSSRPIFSSSLAYTFYRRRILNETINGDAVEALAHQRPSSCAWDGQHGSLRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NSQ7</accession>
    <name>A0A0G4NSQ7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Silar P."/>
                <person name="Lacoste S."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CRL17121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="35" mass="3846" checksum="3B73F803AD15EDD5" modified="2015-09-16" version="1">MSAKVRYLRYLRGIVGNNGMQGFVSSGKVESNKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NT89</accession>
    <name>A0A0G4NT89_PENC3</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642:SF310">
        <property type="entry name" value="FATTY ALCOHOL:CAFFEOYL-COA ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL17286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="521" mass="57306" checksum="E298CE0D59026086" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NU57</accession>
    <name>A0A0G4NU57_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleotide-binding, alpha-beta plait</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S001g000582</name>
    </gene>
    <organism evidence="6 7">
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        <lineage>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="502"/>
            <end position="580"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
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        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
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        <location>
            <begin position="334"/>
            <end position="433"/>
        </location>
    </feature>
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        <location>
            <begin position="463"/>
            <end position="496"/>
        </location>
    </feature>
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        <location>
            <begin position="584"/>
            <end position="704"/>
        </location>
    </feature>
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        <location>
            <begin position="725"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="796"/>
            <end position="843"/>
        </location>
    </feature>
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        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="361"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="464"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
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            <end position="492"/>
        </location>
    </feature>
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        <location>
            <begin position="591"/>
            <end position="615"/>
        </location>
    </feature>
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        <location>
            <begin position="680"/>
            <end position="690"/>
        </location>
    </feature>
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            <end position="834"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL17622.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="969" mass="105436" checksum="50508C5544B33F71" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
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            <taxon>Ascomycota</taxon>
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            <taxon>Eurotiales</taxon>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
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    </reference>
    <comment type="function">
        <text evidence="7">Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.</text>
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        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:translation"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ribosomal_Rsm22-like"/>
    </dbReference>
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        <property type="entry name" value="37S RIBOSOMAL PROTEIN S22"/>
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    </dbReference>
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        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 17, MITOCHONDRIAL"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
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            <end position="46"/>
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            <end position="99"/>
        </location>
    </feature>
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        <location>
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            <end position="832"/>
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    </feature>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00045681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL17658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="832" mass="93292" checksum="2A505CABD997A178" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NV18</accession>
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        <submittedName>
            <fullName evidence="7">Polynucleotidyl transferase, ribonuclease H fold</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">PCAMFM013_S001g000784</name>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oligoribonuclease family.</text>
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        <property type="protein sequence ID" value="CRL17824.1"/>
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    <dbReference type="STRING" id="1429867.A0A0G4NV18"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:mitochondrion"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Oligoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
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    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
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        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
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        <property type="entry name" value="PRK05359.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046:SF0">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005194802" evidence="5">
        <location>
            <begin position="18"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuclease" evidence="6">
        <location>
            <begin position="44"/>
            <end position="222"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL17824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="222" mass="24814" checksum="00865B8CF611A941" modified="2015-09-16" version="1">MLRSIFLPASALRSVLAQPGFLHQPRIAPIRHKSTMPLERSTDPLVWIDCEMTGLNPETDKILQICCFVTDAQLNLLEPTGFETVIHVPDSTLDAMSQWCIDTHGRTGLTAAVRASTTSPSTAADSLLAYIRQHVPVPRTALLAGNSVHADKAFLACAPYSQVLDHLHYRILDVSSLKEAARRWGSDQMLEQVPPKREVHLARDDILESIEEMRYYKEKLFG</sequence>
</entry>
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        </submittedName>
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    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
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                <person name="Debuchy R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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        <source>
            <dbReference type="EMBL" id="CRL18118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="85" mass="9309" checksum="5AD8EB2DB197E764" modified="2015-09-16" version="1">MLVTGSCCISSPRTWLSRLLQSVVVWVADAEATRAIETEKRLRARVTGLEQQIRGTEGQVQDSVGRLPITRSHADPCSSIEAPMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NW55</accession>
    <name>A0A0G4NW55_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S002g000177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NW55"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL18307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="141" mass="15499" checksum="BA9FB2ACBC4C655B" modified="2015-09-16" version="1">MTITEELCYRGDSDSRTPSNATDALPKPANMQYMHCLTGPCIPLKPVPANLTTPKTPMQSGLATTPGDATARIPATSSTCALHMPTRWYRGKKATISYTGVEVSVWKTRVALCQDVARMGRASWVIIQDEISWLTRLGDWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NW85</accession>
    <name>A0A0G4NW85_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Clp protease, ATP-binding subunit ClpX</fullName>
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    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S002g000196</name>
    </gene>
    <organism evidence="6 7">
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Renault P."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
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    <dbReference type="STRING" id="1429867.A0A0G4NW85"/>
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    </dbReference>
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        <property type="term" value="C:mitochondrial matrix"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000138">
        <property type="entry name" value="ATP-dependent Clp protease ATP-binding subunit ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050052">
        <property type="entry name" value="ATP-dep_Clp_protease_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
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        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102:SF7">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="185"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="5">
        <location>
            <begin position="461"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="142"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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            <end position="333"/>
        </location>
    </feature>
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        <location>
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            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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            <end position="612"/>
        </location>
    </feature>
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            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="303"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
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        </location>
    </feature>
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        <location>
            <begin position="376"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="574"/>
            <end position="593"/>
        </location>
    </feature>
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        <location>
            <begin position="598"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL18326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="612" mass="66583" checksum="F2D08C04D7479ABA" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWC9</accession>
    <name>A0A0G4NWC9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWC9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL18356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="82" mass="8977" checksum="41AAA45E0C47A038" modified="2015-09-16" version="1">MVSLVYSPGCLQSTIQLTIRSVYKASRESYSPLTTPGSSRDKSAQVVQTMEALQPIEPDQFPSNCWPIICCGRQVVSVISIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWX7</accession>
    <name>A0A0G4NWX7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Helicase, superfamily 1/2, ATP-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S002g000431</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="CRL18561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1429867.A0A0G4NWX7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070478">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-dependent RNA helicase SKI2"/>
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        <property type="entry name" value="DEAD/DEAH box RNA helicase"/>
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    </dbReference>
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        <property type="entry name" value="DEAD/DEAH box RNA helicase"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
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    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
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    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040801">
        <property type="entry name" value="Ski2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17911">
        <property type="entry name" value="Ski2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="331"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="650"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="229"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="535"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="535"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="545"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="570"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL18561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1300" mass="145937" checksum="149EF7F51D166DA7" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXC5</accession>
    <name>A0A0G4NXC5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S002g000565</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
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        <property type="protein sequence ID" value="CRL18695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
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    </dbReference>
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        <property type="entry name" value="proteasome_beta_type_3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Proteasome subunit beta type-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
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    </dbReference>
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        <property type="entry name" value="Ntn_hydrolases_N"/>
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    <dbReference type="InterPro" id="IPR033811">
        <property type="entry name" value="Proteasome_beta_3"/>
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    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
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    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
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    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF10">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL18695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="206" mass="22534" checksum="CF40A2827D8278AF" modified="2015-09-16" version="1">MSNPFDINGGACVAMVGKDCVAIACDLRLGMQSLTISNNFPKIFNYAPSTYLGLTGLATDVNTVSDLFRYKVNMYRLREERDIAPQTLANLVSSSLYEKRFGPYFVSPVLAGINPTTGKPFICGFDSIGCIDFAKDFIVSGTASDQLFGTCEGLWEPDLAPEDLFETISQALLSAVDRDALSGWGAQVYIIEKDKVTQRLLKGRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NY87</accession>
    <name>A0A0G4NY87_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">25S rRNA adenine-N(1) methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S002g000932</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of an adenine present in helix 65 in 25S rRNA.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
    </comment>
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        <property type="term" value="F:rRNA (adenine) methyltransferase activity"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Bmt2/SAMTOR"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="25S RRNA (ADENINE(2142)-N(1))-METHYLTRANSFERASE"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <position position="119"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
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        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_03044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL19062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="283" mass="31739" checksum="F9D25C1AF294931B" modified="2015-09-16" version="1">MAPQKRSKRPMLLSHSRPRIVKSKDAALSAKATRTLIRSHHRLLKVRAQALAAGDEARVSSIDAQIEANGGLESYQIASKLGQSMDRGGDSSKVLIDWIKPQLKQWNNTIPKLRVLEVGALSTKNACSTNPALDVTRIDLNSQEPGILKQDFMERPLPTSDDERFNMISLSLVLNYVPDATGRGEMLKRCVKFLTSKCPIELVPSLFLVLPIACVDNSRYLNEERLGEIMTCLGFRLTQSKRTSKLVFHLWEHAGTYAPKNFKKEELRSGKTRNNFAVILNKK</sequence>
</entry>
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        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
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        <name evidence="1" type="ORF">PCAMFM013_S002g000983</name>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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            <taxon>Eurotiomycetes</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL19113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NYG4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL19113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="35" mass="3795" checksum="F00011D3986CAC10" modified="2015-09-16" version="1">MVATHEKANSVLDSGRVRCGVRSIAAMLISHLRDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYM3</accession>
    <name>A0A0G4NYM3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SEC7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S002g001045</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
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                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <location evidence="5">COPI-coated vesicle membrane</location>
        </subcellularLocation>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Brefeldin A-inhibited guanine nucleotide-exchange protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Brefeldin A-inhibited guanine nucleotide-exchange protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015403">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046455">
        <property type="entry name" value="Sec7/BIG1-like_C"/>
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    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
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        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF375">
        <property type="entry name" value="LD29171P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20252">
        <property type="entry name" value="BIG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09324">
        <property type="entry name" value="Sec7-like_HDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SEC7" evidence="7">
        <location>
            <begin position="730"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="686"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1126"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1641"/>
            <end position="1686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1133"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1649"/>
            <end position="1658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1669"/>
            <end position="1678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL19175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1920" mass="216491" checksum="50EC02A050161F1A" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYS4</accession>
    <name>A0A0G4NYS4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AMP-dependent synthetase/ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S003g000026</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
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            <taxon>Eurotiales</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4NYS4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19542">
        <property type="entry name" value="CT_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000003">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000014">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF3">
        <property type="entry name" value="SIDEROPHORE SYNTHETASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01294">
        <property type="entry name" value="PKS_PP_betabranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="737"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1383"/>
            <end position="1459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL19235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1900" mass="208987" checksum="E4DCA603AD965027" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZ08</accession>
    <name>A0A0G4NZ08_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer mitochondrial membrane transport complex protein, Tom37/Metaxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S003g000082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZ08"/>
    <dbReference type="STRING" id="1429867.A0A0G4NZ08"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03193">
        <property type="entry name" value="GST_C_Metaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03078">
        <property type="entry name" value="GST_N_Metaxin1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021211">
        <property type="entry name" value="SAM35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF44">
        <property type="entry name" value="OUTER MEMBRANE PROTEIN (SAM35), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17172">
        <property type="entry name" value="GST_N_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10806">
        <property type="entry name" value="SAM35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like fold" evidence="2">
        <location>
            <begin position="73"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="1">
        <location>
            <begin position="222"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL19291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="290" mass="32768" checksum="7A0042AD3F5F0626" modified="2015-09-16" version="1">MPPKGADGPPEESNASPFFTVPAPIKRLFDKFPLTTYPANEIPQRLQPHDNVNQLYVFADASGVRHGRPSFNPQCLKWQAYLKFVGIDFEITSSNNHASPNGSLPFLLPSLPADSSHPIPSHKIQKWAIEQVHCEEEQQLNLRFEVYASLLDNRIRSAWLYMLYLDSENFDAVARRLYVNPTTSNSVVRAALGHQLQQAARDELLKTSRYIDAAALEADAGGAFEALSTLLGEDEHFFGRPNPGLFDASVFAYTQLILDDTLGWKRNRLGQLLKEHPNLVQHRERLLKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZ13</accession>
    <name>A0A0G4NZ13_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S003g000087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZ13"/>
    <dbReference type="STRING" id="1429867.A0A0G4NZ13"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL19296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="71" mass="7961" checksum="6B7973ECCC6A0A1C" modified="2015-09-16" version="1">MPFIQNPFTEETATTKPEMVKTPSEEQKEEALAAALKAGYSKPVFSQSLNYGMDLNVRILEYDQTPCDLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZ41</accession>
    <name>A0A0G4NZ41_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Arginase</fullName>
            <ecNumber evidence="2 11">3.5.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S003g000116</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>L-arginine + H2O = urea + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:20569"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="EC" id="3.5.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="11">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.1" evidence="2 11"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU361159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL19325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
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        </source>
    </evidence>
    <sequence length="324" mass="35328" checksum="2066ABFA05C428FE" modified="2015-09-16" version="1">MTQPSTITSRFLSHPNQLGVVAVGFNGGQCKKGVEAAPMALIESGLLTQLSEDLDYEVHHDNTVHYYENDIPAEDPDHRGMKKPRAVSAVTEKLSSQIYNYAKDGKFVLTLGGDHSIAIGTVSGTAKAIRERLGREMAVIWVDAHADINVPETSGSGNIHGMPMAFLTRLAREEKKDIFGWMQDEHIVSTQKLVYIGLRDVDRGEKKLLRENGIKAFSMHDIDRHGIGRVVEMALAHIGNDTPIHLSFDVDALDPQWAPSTGTPVRGGLTLREGDFICEAVHETGNLIAMDLVEVNPSLEEKGASETIRAGCSLVRSALGDTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZL3</accession>
    <name>A0A0G4NZL3_PENC3</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Sallet E."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="349"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL19498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="366" mass="41576" checksum="A35161B1D07219EB" modified="2015-09-16" version="1">MAAGITPPGSFLEPPLTPPPTVQKPLSRSAQSVINHFRLHRASHRPRFWWEGRLKPDDYTQILCVLDADESLRNYVEDKVRYDYDPCRDCLTIRMPSPVHDTFCARIVDEISRQLRQFQNNDGPLANFAKEVEHFATSRILIPEDTEDGKQTYSRREPDASFGHRQALYPGVIVEVCYSQKSRRISHLADEYILNTDGSVNAVVALDIDYEGSNRATITVWRPEYAIVDGVEEFRATTVIEAQPFRTDSGLPTEGTVLRLSLRDFATEELARGHVDLDCEILITSKQLCDFLSSAEARQQAQTQQRGSINRIRPGALKRRRPQTPLEQPSSEDEGFIERKRESKRGRQSSDYRPSSSSADSRGELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P024</accession>
    <name>A0A0G4P024_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL19643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="320" mass="36626" checksum="6236D89F53B5BEA6" modified="2015-09-16" version="1">MADNTPSWLRKCGLNEGEDCSSPRAPARRRLTSKSAEPAESSDSPESLLPYPIPDDNSVSSDGKIPPAHPDDVSDDTPPVSDEQVEKYYQKGAAYEAWIADPTRDGCPCRQSEHTLFGMFNHSDKKKRFHCTQNHWDDPLPSIKEDLQQLGFPINGKRCRFTRLILHSYDEKGYKRESEYQHSLAEGVIIGECIYRYMGPNWSDIALAQYKFDHPIDTLKYLYFTNVQNEETLPYVQEILYPRHDVDWPRVDRIQSQVWEYGTGDYREILGTKLGNAAACLVLGAWERGTHRIARVHTLGRQHYIHLRFDIEPVPVSGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0F3</accession>
    <name>A0A0G4P0F3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AMP-dependent synthetase/ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S003g000540</name>
    </gene>
    <organism evidence="4 5">
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
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            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
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    <dbReference type="STRING" id="1429867.A0A0G4P0F3"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CARRIER"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="578"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL19749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1077" mass="119138" checksum="7161524529933BE7" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0F8</accession>
    <name>A0A0G4P0F8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S003g000586</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P0F8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
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        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="56"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="98"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL19795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="469" mass="51433" checksum="72A83169FEC35220" modified="2015-09-16" version="1">MFHKFSAVPANADRQTKGPGSARARSKKKKNNNNNNNTSDTDPNPSVAKRQKAARACDRCRLLRIKCGEQKPCTQCVSIKGKCVVSYAPLRSTRTKKIDTDHARSESSTVIFPGLSSPSPTYAGCHDSSGSTSSPTGNPSPVGPTVPPSRVSMVTETRTPENEAAKEFFNIAHVQGFFTSGQPAFSYNSALGGCLFPQLPHPTLPSGECTVALRVLLKSQQSYYLRVFWEVCHQIMPIMSKTEFAELDALPPSTIHDRHSTGGALVNSMIALGIQHTHVTGLVGRVFGLQQSPSRRNYHAGLPPKATWPGFEYFHRCRECMRANTEVTLEALRCHVLMVLYLVAFHDAYNLLGITVRKAYIAKLHRPQLSHLPEAGKTARMQLWWIIFSLDVQCSLQLDMPPASQKSLVKCPFPDEDALARYISSPCEDGMNSYAFSTHLVNIAVIVTDIGACVSTADLLDDDNSNSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0J1</accession>
    <name>A0A0G4P0J1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S003g000629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P0J1"/>
    <dbReference type="STRING" id="1429867.A0A0G4P0J1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07383">
        <property type="entry name" value="MPP_Dcr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440:SF11">
        <property type="entry name" value="METALLOPHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="42"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL19837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="436" mass="48532" checksum="AEF73D0AAD0E43B9" modified="2015-09-16" version="1">MDRSGFGGSSSALAEAPFLRSAYPRRARDERLRLTENGTFQISVFSDLHFAEGTMTNSKRYFGILTIFKDDEADNKTIGVMNDVLSSEEVQLVVLNGDLISGEAITQRSNSSLYVDRIVAPLIDRNLPWASTYGNHDSEVNLDPEEIFHEETKYENSLTQRRVSGSTAGITNYYLPIFPHESSNDSTPVFILWFFDSQGGHYALADDEDRKSVARQSWVDDKVVEWFVEANANLTSTYGQTIPSLAFVHIPAHPMRAFQQSGVSPSREPGINGERVQEQGYDSDTGYISQDLPFIRALLNTTGLAATFSGHDHDNDWCFKWDTGLPGLNVTGNGINMCYGRHTGYGGYGDWARGGRQILLDQQSLGDDVRTWIRMEDGSISGNVHLNATYGRDQYGLAQRSISVQNGGISLPPPYFDGIYLWIWVFSVLISGFHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P121</accession>
    <name>A0A0G4P121_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S003g000770</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
            <location evidence="2 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CGR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P121"/>
    <dbReference type="STRING" id="1429867.A0A0G4P121"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005579">
        <property type="entry name" value="Cgr1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03879">
        <property type="entry name" value="Cgr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004090"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL19978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="114" mass="13500" checksum="198DA230C2FB6B07" modified="2015-09-16" version="1">MSTSTATPVVPPTTGMRKNGKNWHGTKKAFRPTAGLTSYAKRQELKKHSDAVKELEREMKEEAEAERKARIQRIKDRREAKEEKLRYEKMAEKMHHKRLDRLKRREKRNKLLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P1F8</accession>
    <name>A0A0G4P1F8_PENC3</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S004g000053</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
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                <person name="Bensimon A."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
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        <subcellularLocation>
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    <comment type="similarity">
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0810">Translation regulation</keyword>
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            <end position="244"/>
        </location>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
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        </location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01044"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="CRL20113.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="635" mass="68516" checksum="5EA7BE9C0BD370A7" modified="2015-09-16" version="1"> </sequence>
</entry>
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        <submittedName>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Dupont J."/>
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            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="REGULATORY PROTEIN LEU3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL20183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P1V3</accession>
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    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S004g000204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P1V3"/>
    <dbReference type="STRING" id="1429867.A0A0G4P1V3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL20264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="124" mass="14317" checksum="E05F04EFD0F643CE" modified="2015-09-16" version="1">MDVLGREIRQYERTKREEHLEESIRVSRWAVQATSHGHSTHTIQLNNLSRGGCNKGDDRNFTFLGIENQISFYEADLLPRNRPEIYATPRDGRLDLEFEGNRQLIGGDNVLRLIQCLETEFSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P280</accession>
    <name>A0A0G4P280_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S004g000365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P280"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL20425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="49" mass="5486" checksum="E11EF1F664B36D7E" modified="2015-09-16" version="1">MFFKFGFTHGYRKSGGELEKLVGLSPNSPLQLSRIKAADQYSKVPNLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2B9</accession>
    <name>A0A0G4P2B9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S004g000406</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P2B9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF4">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="4"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL20465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="320" mass="35027" checksum="FA40BF31A767BC17" modified="2015-09-16" version="1">MVVVAVAGGSSGLGLTIVQALKVQGKHEVLVLSRKENTELGKRLGALVVAVDYRSANSIEAALEANNVDTVICTINSQDDLEPERNLILAADRSPVTKRIIPSIFAGFTYPIKYPDSSPVAKAKAEAIKAVKKTSLEYTAIYNGIFLDYYAAPQLKANIPPWPLFVDILHESAAVPGSGDDLVVFTHSTDIAKFVVSSLDLPKWREESYILGEKFTWHEFIKLAEDAKGSKFNVVHDSEADLSAGRVSMLPSYGKMFQLPEADIQALLSTAGMWFVNKELDLNPTHALNKDFPEIKPTKVKDFLESSWKVTDATGSEVKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2L2</accession>
    <name>A0A0G4P2L2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">EF-hand-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S004g000507</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P2L2"/>
    <dbReference type="STRING" id="1429867.A0A0G4P2L2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048306">
        <property type="term" value="F:calcium-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16180">
        <property type="entry name" value="EFh_PEF_Group_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051426">
        <property type="entry name" value="Peflin/Sorcin_CaBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212:SF3">
        <property type="entry name" value="GH27120P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212">
        <property type="entry name" value="PEFLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="210"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="240"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="63"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="130"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL20566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="353" mass="38974" checksum="D2E7A3E5F7DA1BF1" modified="2015-09-16" version="1">MAYNKSYNPDALPAHAEPEQVAQMIGNLSVSGQSHAPSHAPSHTQSLNQKPLPTRPPPQTTHSSGVPPRVPVSSAPPQHAYAAAPPRLEPHQSQSHSHSHSYSGRPSSANLPPPSQPLSQSQSQSRPHPLHPSPPPQNYGFGPPPVHPQRNRPPPSSRPPQSPVPPPLTAPSDDPQQLFPLFRAANASHSGALTEGELGSALVNGDYTSFHPRTVRLMIRMFDRDGSGTINFDEFVSLWRYLAAWRELFDRFDEDRSGRVSQPEFEKALVAFGYRLSGKFISIIFGVFESKGKQMSNAPKDPRLTGMSFDLFVQACISLKRMTDVFKRYDDDRDGYITLSFEEALTEILLLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2T7</accession>
    <name>A0A0G4P2T7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Archaeal translation initiation factor aIF-2, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S004g000499</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
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    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4P2T7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
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        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor IF2/IF5" evidence="5">
        <location>
            <begin position="150"/>
            <end position="260"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL20558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="281" mass="30882" checksum="0E58847DD69B6343" modified="2015-09-16" version="1">MDTNGQVTDAPPAEKPTGEKDVDEVTEMFKGLSKKKKSSKKSKTADAGDDEEAPAAADGEFDPSALKKKKKSSSKSKKVDPNDFDAKLAEAGIAEEAGEDQPEELPEGDLEAGTGIWAHDATQAIPYSLLVSRFFSLIESHHPDLLSSGAKSYKIPPPQCLREGNRRTIFANIADICKRMKRSEEHCTQFLFAELGTSGSVDGSRRLVIKGRFQQKGIESVLRRYIVEYVTCKTCRSPDTELNKGENRLYFVTCNSCGSRRSVAAIKTGFRSQIGRRKRVG</sequence>
</entry>
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        </submittedName>
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    </gene>
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        <lineage>
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            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL20768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="119" mass="13733" checksum="822A51B59AE6A837" modified="2015-09-16" version="1">MLTDFAEAITKYRQRVSDETHYTVQHYMDRILTFEPPTHGNDLGQPDDYDGRNVDENWGFSLANTTQASPLVFPMGLPTANADEIMRDQHDGWLDGSIPFPEFFVPELEPFDQLFYTVE</sequence>
</entry>
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    <accession>A0A0G4P4N0</accession>
    <name>A0A0G4P4N0_PENC3</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S005g000428</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10028">
        <property type="entry name" value="UDG-F2_TDG_MUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.470.10:FF:000010">
        <property type="entry name" value="G/U mismatch-specific DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015637">
        <property type="entry name" value="MUG/TDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159">
        <property type="entry name" value="G/T AND G/U MISMATCH-SPECIFIC DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159:SF9">
        <property type="entry name" value="G_T MISMATCH-SPECIFIC THYMINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="324"/>
        </location>
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            <end position="23"/>
        </location>
    </feature>
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        <location>
            <begin position="41"/>
            <end position="142"/>
        </location>
    </feature>
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        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
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        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL21264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="353" mass="38758" checksum="4BA65B1C89DA3EA4" modified="2015-09-16" version="1">MPPSTEIQPKVEEDELPLETMEDVPVNKITSFNGKLQQYLHSGTASQEAPSASGNTISQRHINTTKTEYKPPITKRQEKASNPSPRRKRTVPQTTLSETTTTHLSTTRSQSILTTTPPSPNKRKRSRATPQLPPTLPLAGPSATQSLLRDTIPPNLILLLVGVNPGIMTGITGHAYAHPSNLFWKLLFSSGITSMRHIPADTYKLPALYSVGNTNIVERPTRDASMLSRAEMDAGVPVLEAKVAAQRPEVVCLVGKGIWEAVWRVRHGRGIRKEEFRYGWQAEEENMGRCDGWAGAPVFVATTTSGLAAGMKLAEKEAVWAELGSWVVRRRGGRGLDSVVVTEEVKEEVKEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P4P0</accession>
    <name>A0A0G4P4P0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P4P0"/>
    <dbReference type="STRING" id="1429867.A0A0G4P4P0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL21253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="88" mass="10095" checksum="28E32BF7AB6AF600" modified="2015-09-16" version="1">MAFLGQSPFANWVTILEYRARLVTAGYARESVEIRDFSEKVFGQLARFLKKTELEVGLSIGHFQYAARMFDWWCRIGVVGGYIAVARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P4Q6</accession>
    <name>A0A0G4P4Q6_PENC3</name>
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        <submittedName>
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        <name evidence="4" type="ORF">PCAMFM013_S005g000437</name>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="fungal_TF_MHR"/>
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    </dbReference>
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        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="235"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL21273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="618" mass="69045" checksum="EDB283E306CE3D45" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P588</accession>
    <name>A0A0G4P588_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PCAMFM013_S006g000015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL21475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="37" mass="3891" checksum="2233DE49CC3F2C44" modified="2015-09-16" version="1">MASAKPTKPKAHKAQSPTQPNPRMGWALGPVLGPILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5C6</accession>
    <name>A0A0G4P5C6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S006g000066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL21526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="110" mass="12549" checksum="0FDD3D80121A21F1" modified="2015-09-16" version="1">MFLGEVANGCLVSGFPLVVPQGDSQYQHMGLSSQSTYFRRGLQQIQPRPLASNRDELYRLISGQCANNKTYGYDQSPGRSLAQFEQLKLVATLRRDYDIEQVDVRKEWAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6L8</accession>
    <name>A0A0G4P6L8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S006g000512</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4P6L8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL21972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="272" mass="28584" checksum="00C727FDE6766F7F" modified="2015-09-16" version="1">MSVDGFALVTGAGSGIGRDCSMAFASEGAKGVAFADINLTAAMEAAEESKAQASNSAYRAIALQVDVSNEESVQRMVDTTLKEFNRIDYSVNSAGLGIKNARPVSETCMAEFDNLMSVNVKGTMLCVRAVSRAMKTQEERLVAGRTGPFNVGRGSIVNLASANSVVAFPEIVQYTAAKHAVLGITKTADNAPHGIRVNAVCPSWVETPMIDKAFEGNPEIRLALSASIPAGRLAHPEEVSNVVLFLSGPKSTYVTGVGWLVDGGTTLQMKHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6Q0</accession>
    <name>A0A0G4P6Q0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S006g000429</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793139">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P6Q0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL21889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="54" mass="6160" checksum="5AD0F9378B46FB9B" modified="2015-09-16" version="1">MTGIGMMKKMSPSPIKVEDLDNWIDTVEKILEGHNLQNLIKKSVPWPTRRDPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P747</accession>
    <name>A0A0G4P747_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S007g000065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P747"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL22084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="220" mass="25802" checksum="024DA4DBB776268E" modified="2015-09-16" version="1">MNSKRDRIPIRRVSRSVSRGNGCMPHVSDSRRLLDDSWDEGSFQSFDATHYALQTLNKHIERRLAKLQANTVRLKRELWLLQRHIKEFRHPLFENWEADLLTRLIEVAHAHQHKKLPGGVVIGESSFAERENINHAYSIAAKGIRMPTLRKLGLSEKYHQALQRYSEVAPYRSPNPFQTEFAFAKWLVEVRDDRPELYGFWSKLFPVCYDRTVQESASIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7K6</accession>
    <name>A0A0G4P7K6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S007g000258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P7K6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL22277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="444" mass="51760" checksum="2DD9E62859D92C3A" modified="2015-09-16" version="1">MNNQTCSNCSISSSKHKELVGWVWDNPGRGTISLITTCLATIFMCTWVVIHPRVYKRESYANLHKFALFLKTIFAPEFIAVEGLQEWAQCRRMQRECADSTAGQFKLVHAFYVSMLALRYKTPNGDRVIWPNQYTWLLQQNLIRWEDHPSWGLSLDDICDKSKSDNAAKLLALIQVTWFSAQCILRVSYHLPLSQLESMTLGYIPLFIVTYFFWWNKPKDIRSPSLVALPGMSLEQFHFFESMAVSNKFDNEGMKEQTSYWNIWYLTPRVFEKVEADRLVQEAQTKTLKSPNQNPITEQPHEPTINEIEIRDLEDPHESRKDIVVSHWDPDLYRSRIWPLACLFGISFGALHLVSWNTMFPSIVELWLWRVSAFVSIVSMLIFMHFEKVVLRWDGILTVFSLSSPVFYLLGRIVMIAEVFAALRAADPAIYDTYEYSVYWLPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7P0</accession>
    <name>A0A0G4P7P0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">V-type proton ATPase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S007g000309</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P7P0"/>
    <dbReference type="STRING" id="1429867.A0A0G4P7P0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000003">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="entry name" value="ATP synthase (C/AC39) subunit, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1690.10">
        <property type="entry name" value="V-type ATP synthase subunit C domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_csu/dsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016727">
        <property type="entry name" value="ATPase_V0-cplx_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035067">
        <property type="entry name" value="V-type_ATPase_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_csu/dsu_dom_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11028">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018497">
        <property type="entry name" value="V-ATP_synth_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="V-type ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR018497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL22328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="364" mass="40782" checksum="6FE6E6F64217260B" modified="2015-09-16" version="1">MEGLFFNVNGGYVEGIVRGYRNSLLSGQNYSNLTQCETIDDVKLQLAPSYGDFLASLSPNPSTSDLASRMTDKLVAEFKYLIAQATGSSAKFLEYMTYGYMIDNIALLITGTLHERDTRELLERCHPLGWFETLPVLCVATNIEELYNSVLIETPLAAYFKGSLSHQDLDELNIEIVRNTLYKNYLEDFYNFINTHPDFSGTPTQDVMAEILQFEADRRSINITLNSFGTELSKLERRKLYPEFGKLYPEGSLMLSRAEDVEGVALAVSAVADYKAFFDAVGLSQGGGGLGGMGGGPADGKSLEDLFYQKEMDLSKLVFTRQFTPAVVYAWMKLKEQEIRNVTWISECIAQNQKERIGNFISVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7S8</accession>
    <name>A0A0G4P7S8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S007g000328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P7S8"/>
    <dbReference type="STRING" id="1429867.A0A0G4P7S8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053144">
        <property type="entry name" value="Acetyltransferase_Butenolide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43233">
        <property type="entry name" value="FAMILY N-ACETYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43233:SF1">
        <property type="entry name" value="FAMILY N-ACETYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="32"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL22347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="191" mass="21617" checksum="AEAA37FF522A727A" modified="2015-09-16" version="1">MSSTPPTSGHPPKTWTRDTSPEFFISTEPSLLSVKAVNAAYERDFIYWVQKPFPEEVLWQMLHGALSFGVYRWTQPAESVNDSTTPSSENTEQIGLARAVTDGCSFAYLSDIYVLPEYQGSGLGKWLVGCIAETLSKDNMPYLRRIMLLTDDERMQAFYAKMFGVKVVGREERKDMGRDLVFMCARPHAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P8E0</accession>
    <name>A0A0G4P8E0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S007g000548</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P8E0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF12">
        <property type="entry name" value="TRANSCRIPTION FACTOR ASQA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="88"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL22567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="733" mass="82361" checksum="21F93D1BB3920C82" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P9J2</accession>
    <name>A0A0G4P9J2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S008g000378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P9J2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL22949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="66" mass="7333" checksum="FF1C8F389C6AE0D0" modified="2015-09-16" version="1">MMGITDGQEAISTWIKGPDIKVLRGFPKPNNVFLIWGAIEYPKKKKASMISSDLEDMRGDHNAIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P9Y8</accession>
    <name>A0A0G4P9Y8_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S009g000068</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P9Y8"/>
    <dbReference type="STRING" id="1429867.A0A0G4P9Y8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03752">
        <property type="entry name" value="proteasome_alpha_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000009">
        <property type="entry name" value="Proteasome subunit alpha type-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL23128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="255" mass="28381" checksum="6B349EFCD3B3CE9F" modified="2015-09-16" version="1">MSRRYDSRTTIFSPEGRLYQVEYALEAISHAGTALGILAKDGIVLAAERKVTSKLLEQDTSAEKLYTINDNMICAVAGMNADANILINYARQNAQRYLLTYNEDIPCEQLVRRLCDLKQGYTQHGGLRPFGVSFIYAGYDHLRQFQLYQSNPSGNYGGWKATSVGANNASAQSLLKQDYKEDCDLKEACAMAVKVLSKTMDSTKLSSEKIEFATVGKTKDGKIYHHLWTADEIDSLLREQGLAKVDDEPEAGDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAJ5</accession>
    <name>A0A0G4PAJ5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Uroporphyrinogen decarboxylase</fullName>
            <ecNumber evidence="4 14">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PCAMFM013_S009g000277</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the sequential decarboxylation of four acetate groups of uroporphyrinogen-III (octacarboxyporphyrin) to yield coproporphyrinogen-III (tetracarboxyporphyrin) with the formation of intermediate hepta-, hexa- and penta-carboxylate porphyrinogens in the heme biosynthesis pathway. Acts on a number of porphyrinogens, but only coproporphyrinogen III can ultimately be converted to heme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>uroporphyrinogen I + 4 H(+) = coproporphyrinogen I + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:31239"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:62626"/>
            <dbReference type="ChEBI" id="CHEBI:62631"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>uroporphyrinogen III + 4 H(+) = coproporphyrinogen III + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="4 14"/>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PAJ5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PAJ5"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000004">
        <property type="entry name" value="Uroporphyrinogen decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00218">
        <property type="entry name" value="URO_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01464">
        <property type="entry name" value="hemE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091">
        <property type="entry name" value="METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091:SF169">
        <property type="entry name" value="UROPORPHYRINOGEN DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 14" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="16">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="17">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CRL23337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="363" mass="40612" checksum="A34F346FDFC364E1" modified="2015-09-16" version="1">MQEQFEPLKNDLLLRAARGEKVERPPIWVMRQAGRYLPEYHEAKGGRDFFECCRTPEIASTLTLQPIERYEGLIDAAIIFSDILVIPQAMGMVVEMLDKKGPHFPEPLDSPTDGQYEKVMAKKVDVKAELDYVYKAITLTRFKLKGRVPLIGFCGAPWTLLCYMVEGGGSKLFVQSKKWVYKYPTEAQALLQKIAEICVEYLALQVAAGAQLVQVFDSWAGELSPVSFKSFSLPYLRHISANLPKRLKEMGLEPVPMTVFAKGAWYALDDLCDSGYNVVGLDWLHDAGEAMRIANGRVTIQGNADPGMLYGGPPAITATLEPMVEGFKKGKQGWICNLGHGVTPFVDPENLKFFFEEIHRLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAQ2</accession>
    <name>A0A0G4PAQ2_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome quality control complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S009g000337</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NEMF family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PAQ2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PAQ2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.310.10:FF:000003">
        <property type="entry name" value="Zinc knuckle domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.310.10">
        <property type="entry name" value="ibrinogen binding protein from staphylococcus aureus domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021846">
        <property type="entry name" value="NFACT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051608">
        <property type="entry name" value="RQC_Subunit_NEMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239">
        <property type="entry name" value="NUCLEAR EXPORT MEDIATOR FACTOR NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239:SF6">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11923">
        <property type="entry name" value="NFACT-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05833">
        <property type="entry name" value="NFACT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT RNA-binding" evidence="8">
        <location>
            <begin position="547"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="NFACT protein C-terminal" evidence="9">
        <location>
            <begin position="941"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="437"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="494"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="690"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1059"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="332"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="437"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="494"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="730"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="752"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="770"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="798"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="818"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="861"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="887"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="910"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1073"/>
            <end position="1085"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00070414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL23397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1091" mass="120958" checksum="2B68996F47CFE307" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAS8</accession>
    <name>A0A0G4PAS8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Extracellular membrane protein, CFEM domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S009g000340</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PAS8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PAS8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195528" evidence="10">
        <location>
            <begin position="19"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="11">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="51"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL23400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="90" mass="9488" checksum="AFF81C1B2B283D11" modified="2015-09-16" version="1">MKLTIFFPLAAFLSLTVADPSVDASPCLNRCLSEAAAVSGCISSIDYKCTCPSKAFKDTLGTCLEVSCTPDDLTAAGELHKERCGEDPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBQ4</accession>
    <name>A0A0G4PBQ4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carboxylesterase, type B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S010g000153</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PBQ4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PBQ4"/>
    <dbReference type="ESTHER" id="penca-a0a0g4pbq4">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195411" evidence="1">
        <location>
            <begin position="18"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="46"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL23715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="519" mass="56678" checksum="6C4574DB85493201" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCD3</accession>
    <name>A0A0G4PCD3_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10 13">Catalase</fullName>
            <ecNumber evidence="3 10 13">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCAMFM013_S010g000367</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 13">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 13">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="3 10 13"/>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PCD3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PCD3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070301">
        <property type="term" value="P:cellular response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03132">
        <property type="entry name" value="GATase1_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000003">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024712">
        <property type="entry name" value="Catalase_clade2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043156">
        <property type="entry name" value="Catalase_clade2_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041399">
        <property type="entry name" value="Catalase_large_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821:SF1">
        <property type="entry name" value="CATALASE-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038927">
        <property type="entry name" value="Catalase_clade2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 10 13" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 10 13" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="15">
        <location>
            <begin position="31"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CRL23929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="726" mass="81707" checksum="779BA76954F9EA32" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCD9</accession>
    <name>A0A0G4PCD9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosomal protein L7, eukaryotic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S010g000410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PCD9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PCD9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018038">
        <property type="entry name" value="Ribosomal_uL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005998">
        <property type="entry name" value="Ribosomal_uL30_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012988">
        <property type="entry name" value="Ribosomal_uL30_N_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01310">
        <property type="entry name" value="uL30_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08079">
        <property type="entry name" value="Ribosomal_L30_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00634">
        <property type="entry name" value="RIBOSOMAL_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30 N-terminal eukaryotes" evidence="6">
        <location>
            <begin position="15"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="5">
        <location>
            <begin position="91"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="21"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL23972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="250" mass="28880" checksum="05CBC98A1469F4BA" modified="2015-09-16" version="1">MAATTSVPTQNQVLVPETLLKKRKSQEAARAERRAEAEQTKKANKEKRGVIFKRAESYVQEYRTAEREKIRLNRVARQEGSFFVEGEPKLVFVVRIKGINKIAPKPRKILQLLRLLQINSGTFIRLTKATQEMLTIVNPYIAYGYPNLKSVRELLYKRGYGKVDKQRTPLTDNQIIEEHLGKFGIVCMEDLIHEIYTVGPNFKQANNFLWPFKLSNPNGGFRTRKFKHYIEGGDTGNREENINGLIRQMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCF7</accession>
    <name>A0A0G4PCF7_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S010g000431</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PCF7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PCF7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01446">
        <property type="entry name" value="DSP_MapKP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18533">
        <property type="entry name" value="PTP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000142">
        <property type="entry name" value="Protein tyrosine phosphatase (Pyp1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF561">
        <property type="entry name" value="PROTEIN TYROSINE PHOSPHATASE 36E, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="6">
        <location>
            <begin position="187"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="441"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="617"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="109"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="550"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
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            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
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        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
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        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL23993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="741" mass="81836" checksum="A1E83913202E162C" modified="2015-09-16" version="1"> </sequence>
</entry>
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    <accession>A0A0G4PCR3</accession>
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        </submittedName>
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    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
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        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032817">
        <property type="entry name" value="Mon2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF333">
        <property type="entry name" value="PROTEIN MON2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16206">
        <property type="entry name" value="Mon2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Mon2/Sec7/BIG1-like dimerisation and cyclophilin-binding" evidence="7">
        <location>
            <begin position="4"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2/Sec7/BIG1-like HUS" evidence="5">
        <location>
            <begin position="200"/>
            <end position="354"/>
        </location>
    </feature>
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        <location>
            <begin position="1004"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="483"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="601"/>
            <end position="652"/>
        </location>
    </feature>
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        <location>
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            <end position="807"/>
        </location>
    </feature>
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            <end position="513"/>
        </location>
    </feature>
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        <location>
            <begin position="610"/>
            <end position="622"/>
        </location>
    </feature>
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        <location>
            <begin position="631"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008144"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
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        </source>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="CRL24135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1745" mass="193235" checksum="E9A7D1DC0D7991C7" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
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    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PD45"/>
    <dbReference type="STRING" id="1429867.A0A0G4PD45"/>
    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
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        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22584">
        <property type="entry name" value="Rcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
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        <location>
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        </location>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL24253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="252" mass="29042" checksum="62B0C89B3BAE8DD5" modified="2015-09-16" version="1">MSKVSMGTAMSLGLQTEDDLSKDEKKRTSSNSLRLDIQQLGNSIENAINLTDSPKPEIWHECVSCRDNHLQDDMIKTKCSHFYCKACLVRLFKNALRDESLFPPQCCKRPIAASERMLGSTLVQKHKEKAIELNDPDRTYCSNSKCAQYLPRKPTRNRICKCTRCGVRTCRKCKKGDHQGTCVYKLDALLEELADSKQWQRCSNCSRLIELSTGCYHITCFCKYEFCYFCGKRWKTCKCSFADEENLYERDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDA9</accession>
    <name>A0A0G4PDA9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S011g000305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793144">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PDA9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22794">
        <property type="entry name" value="THAP DOMAIN PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22794:SF2">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL24311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="629" mass="67729" checksum="DA35A491A4D3DBEA" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDD7</accession>
    <name>A0A0G4PDD7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S011g000298</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PDD7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL24304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="147" mass="15952" checksum="031F88DCB477D780" modified="2015-09-16" version="1">MVPIPILNPVLGKPLHNGGVNRDNSIAWMVAQGFAPARSCLVRFTAFDPATKDARVITGSFGLPNAITFLPDHKMVYITDSPETNDEAKEDVLPTPLYIDLNPRNSVCGFGVGLPLPSYVFDAIKLYSVLLNLISVKVKSVRIIDTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDM0</accession>
    <name>A0A0G4PDM0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ATPase-like, ParA/MinD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">NBP35</name>
        <name evidence="12" type="ORF">PCAMFM013_S011g000381</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PDM0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PDM0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904564">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly scaffold complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000427">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03038">
        <property type="entry name" value="NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028601">
        <property type="entry name" value="NUBP1/Nbp35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF35">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="11"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="84"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL24387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="343" mass="36555" checksum="001047974538258D" modified="2015-09-16" version="1">MAPYVEEFAEESLAVSSKAPPNLVAPEPEHCPGPESEQAGQGDACAGCPNQQICATAPKGPDPDIPIITERLSQIRHKILVLSGKGGVGKSTFSTLLAHAFAANPDSTVGIMDTDICGPSIPKMMGVESETIHISNAGWSPVWVTDNLGAMSVQFMLPNRDDAVIWRGPKKNGLIKQFLKDVDWGELDYLIVDTPPGTSDEHLSVNSLLKESGVDGAVVVTTPQEVSLLDVRKEVDFCRKAGIKVLGLVENMSGFVCPNCTHESQIFRATTGGGRRLAKKMGIPFLGAVPLDPRVGMACDFGESFVDNFPDSPASKAIKRVVRLVGQAVGENPDDVLPEDVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PF34</accession>
    <name>A0A0G4PF34_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S013g000130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL24887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PF34"/>
    <dbReference type="STRING" id="1429867.A0A0G4PF34"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF1">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL24887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="282" mass="31760" checksum="77BA5C516908D64B" modified="2015-09-16" version="1">MSDQRNIYGYNPSLPAAIIFIILFSASTAHHGYQLTKSKCWYFIPFVIGGIFQIIGYICRAASHDNFYGIPLYAMQTLFILLAPPLYAASIYMILGRTVTYLQAEHLSMVPIKWMTKIFVTGDVFSFFLQCAGGGLMSTGGSMREAGSNITIGGLVVQLLFFGFFVIVTTVFHFRISRQPTSKSQSDRDQTCSDGWRQRNWFTILVGLYIASFLILVRSVFRLVEYKEGYNGYTMTHEVFMYIFDGLLMLIAMVVMNVCHPAEVIGNGKEGSRDYSDVVQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PFC4</accession>
    <name>A0A0G4PFC4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mannosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S013g000213</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL24970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PFC4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PFC4"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF2">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE ALG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL24970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="592" mass="66342" checksum="07B324F9B1A17F39" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PFX8</accession>
    <name>A0A0G4PFX8_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S014g000107</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PFX8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PFX8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10380:FF:000007">
        <property type="entry name" value="Malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000182">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF32">
        <property type="entry name" value="NADP-DEPENDENT MALIC ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="11">
        <location>
            <begin position="86"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="10">
        <location>
            <begin position="274"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="581"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="581"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL25211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="602" mass="66828" checksum="4527F6914C13013F" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PHL5</accession>
    <name>A0A0G4PHL5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycosyl transferase, family 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S016g000111</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793149">
        <property type="protein sequence ID" value="CRL25830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PHL5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PHL5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF2">
        <property type="entry name" value="MANNOSYLTRANSFERASE KTR5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="312"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL25830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="505" mass="58366" checksum="9C388E28928D55A4" modified="2015-09-16" version="1">MSFIQRITKRLPSAPSLPLEDAPSEKGHLHPRFAFFRRRIRLKGNSSISIPLGLVLLFPCLVIVLILLLFVRHPASPGGILIPAGTPPSIRKISEKHDKVFATGCMPIEPDQIAKAPRANAAFVVLARNKELDGVIQSLKSIERHFNRWWHYPYVFLNDGDFDEEFKATVKNYTSAEVEFGKIDNSMWGFPDWVDHEVAKEGIKKQGDAAIMYGGMESYHHMCRFYSGNFYKHPLLMKYEWYWRLEPEIKYFCDITYDPFLKMAEANKTYGFTIAVKELRETVPNIFRYAAAYKRKNNLKSKGLWEMFLEQPEQPETPEENKQDKLPDEILQTDPGDNNLKDVDPEAMEGESYNMCHFWSNFEIARLDWFRSKEYEDFFTMMDRSGGFWNERWGDAPIHSLAAGALLAPSDIHYFRDFGYRHTTIQHCPANAPARQLTRIPYLEKTTDDEKKRIEEDEYWANPDQVKENGVGCRCRCDTDIVDVEGKQGSCLNEWVDVAGGWASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PHV6</accession>
    <name>A0A0G4PHV6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S016g000223</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as a component of both the DNA-binding general transcription initiation factor complex TFIID and the transcription coactivator SAGA complex. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription. At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B. SAGA interacts with DNA via upstream activating sequences (UASs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TAF10 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793149">
        <property type="protein sequence ID" value="CRL25942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PHV6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PHV6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003923">
        <property type="entry name" value="TAF10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03540">
        <property type="entry name" value="TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017246">
        <property type="entry name" value="TFIID_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="172"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL25942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="239" mass="24140" checksum="818BF8937D4B1848" modified="2015-09-16" version="1">MADSQTSQPPQPTPQNGSQEHPPPSESEANIKTEPDLDASIEKDVEMNTETQTGANANASAPGQDPMAPAPEPSKKETSLREFLGKMDDYAPIIPDAVTAHYLTLAGLPPPGTGPGQTPPHLARLLALAAQKFVSDIAADSYQFARIRASNSSSANNPIGSLAAAAGLGAPAGAGGAPAPGGDGGKGNKAGTHLGIQRPGFGGGGSGGSGQGRTVLTMEDLGMAVSEYGVSVKRGEFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PHV7</accession>
    <name>A0A0G4PHV7_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Porphobilinogen deaminase</fullName>
            <ecNumber evidence="5">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Hydroxymethylbilane synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S016g000165</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="EC" id="2.5.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HMBS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="5"/>
    <dbReference type="EMBL" id="HG793149">
        <property type="protein sequence ID" value="CRL25884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PHV7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PHV7"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.40:FF:000002">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000005">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000086">
        <property type="entry name" value="Probable porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="entry name" value="Porphobilinogen deaminase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557:SF0">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobilinogen deaminase N-terminal" evidence="13">
        <location>
            <begin position="11"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobilinogen deaminase C-terminal" evidence="14">
        <location>
            <begin position="238"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CRL25884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="339" mass="36586" checksum="164A8C130E5E336C" modified="2015-09-16" version="1">MSTPAPTQKTITIGTRKSKLALLQTNLVLDALKKAFPQYEYKVFSKETAGDLNTTIALRDFTTKNLWTEELEELMIGGQVDVIVHSLKDVPTTLPSSCKLGPSMPREDSRDVLVVKQGLPYKSLSEIPAGSVVGTSSIRRTAQLARKYPHLKVQDVRGNIGTRLSKLDAEDSPYACVILAAAGLLRLDLEDRITQYLDSKNSGMLYAVGQGALGIEIRKEDTVLQEMLDTIGHQDTTFSVLAERSLLRTLEGGCSAPLGVETEWVHNAQGAKQLRMRSVVVSVDGKECAQVELDADVTSAESAEAFGITVAKALVADGAGDILEAIQQNKAKESVSTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PIX1</accession>
    <name>A0A0G4PIX1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S018g000012</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PIX1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PIX1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF1">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="11">
        <location>
            <begin position="72"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL26319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="620" mass="69015" checksum="0993B7D7EA5F668F" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJL2</accession>
    <name>A0A0G4PJL2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S018g000044</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4PJL2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PK68"/>
    <dbReference type="STRING" id="1429867.A0A0G4PK68"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15760">
        <property type="entry name" value="FYVE_scVPS27p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164:SF30">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="154"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="67"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL26820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="267" mass="29460" checksum="F3096CE61FAB1A4D" modified="2015-09-16" version="1">MATHVMTNTATNQISVYGQPSPTNSATNTPSNNSPTSPRMTTASLHQLPLQSRQLRPLKGPLYVPAALRPTERPQKSSPITPPRSVHGSLDSLNEDSSEPISRRSTMESQSSEISQSAQHEWLKNEHLGAVTGLPTRTHWKADSASSNCDSPTCRSSFGIFLRRHHCRHCGHVFCASHTPHLVPLDQDARFHPDGVPSRACDLCWSAHQRWEENRSDRLSKIQNTIDAQQIGMSVPEGMNAEDPESTVGQTGEVAASVPRDWNWSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKC5</accession>
    <name>A0A0G4PKC5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alcohol dehydrogenase superfamily, zinc-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S019g000055</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKC5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PKC5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052585">
        <property type="entry name" value="Lipid_raft_assoc_Zn_ADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43482">
        <property type="entry name" value="PROTEIN AST1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43482:SF2">
        <property type="entry name" value="ZINC-BINDING DEHYDROGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G15030)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="59"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL26638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="423" mass="45606" checksum="11FC4EAC35F3DD32" modified="2015-09-16" version="1">MSTTSTCLQLEELQKTPTTFHQYLFSDSLSDYSNESRSESEPPSPRSEESRQRVLLLKGAREQYALVDDHAIPSVLHEGEILVKVLTIGLNPVDWKGPAFNFGIPSLPWINGRDLAGLVLQVPKGSSRLRVGDVVLVPSTDYRDIRKAAFQEYAIATDFNAARIPSSTSIHASASVGVAFVAAALALGVSFGLDFSLITQVPGPNLPNIIKKLDRNDIPADIHEECFASLLDSEKPQRGDWVAIWGASTTTGLITLQLAKLAGLRVICVADAARHGAKLVKSGADLLVDRHDPDRAVEIIRGVTEGKLRYAIDIVGRETATQLEKALNPDGHAHLLGLSGLPKEKTPGVQYHTVPIKLFHTAPTVGEAMVCWLEDLLHTTNLTLPEIVHAEGGLEGINAALETLRSGSVSGKRIVVDLGSAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKC7</accession>
    <name>A0A0G4PKC7_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S020g000004</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HG793153">
        <property type="protein sequence ID" value="CRL26845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKC7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PKC7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000306">
        <property type="entry name" value="IKS protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000699">
        <property type="entry name" value="Probable serine/threonine-protein kinase iksA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF138">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE IKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the Mediator complex subunit 20 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793157">
        <property type="protein sequence ID" value="CRL27824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PNA0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PNA0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013921">
        <property type="entry name" value="Mediator_Med20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08612">
        <property type="entry name" value="Med20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL27824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="331" mass="36018" checksum="64DC05E7A2499D6E" modified="2015-09-16" version="1">MPITGVYFIPSNPNASTALQIITERLRAAFPNEELTPIGRWGLEQKLLRDTPGLLPSSNSNKKPPNPRYMQFLSLTHYPTHGFIYTSEPEKPAPAPNQNQNQGAPGPVNAIAPDHSPSPPMVMTTIPPSSYGTLFQHFTYACQPIWSHRLTLAVPNGIVYEVGDFRVRLGDVRQTFPTARVRGTVVEIEWRGPSVVEAIPVDREDGSFSAGVGTGGDGNVDVEAAGIDLASSAIEESDIDAEYAATASLIREFWGRLGVDAREAILIPNVGMEVKDRLRRWKKAGSGVDARVDTSVDGAGSVVGERADEDPDPWSGADVARQFMEVLRFNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPD9</accession>
    <name>A0A0G4PPD9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S025g000039</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793158">
        <property type="protein sequence ID" value="CRL27981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PPD9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PPD9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000045">
        <property type="entry name" value="Aldo-keto reductase (AKR), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="33"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL27981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="316" mass="35567" checksum="6E095EB59B4CA375" modified="2015-09-16" version="1">MTRSVGKMWEKYCLRPTQGTVSTTIPVFVYGTAWKKERSADLVYNAIKAGFRAVDTAAQPRHYQEHLVGDGIRRAIADGIVGRADLYVQTKYSPVSAQDLANMPYDPSATVTDQVHASIKSSLHNLRSTIDPDSVDESYIDTVIIHSPLSTLAQTLEAWHALETYVPRHIRNLGISNCTLPILRELCTSSQTTVKPSVVQNRFYEDTLFDVPLRAFCRENQIIYQSFWTLTANPDLVRSEPVQQLAHHVNITPAAAFYTLVMGLEDVVVLNGTKDESRMKEDLSAPKQVENFTQKQPELWQQILTDFRGLIGESRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPH7</accession>
    <name>A0A0G4PPH7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">EF-Hand 1, calcium-binding site</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S026g000165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793159">
        <property type="protein sequence ID" value="CRL28300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PPH7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PPH7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011431">
        <property type="entry name" value="Trafficking_Pga2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28199">
        <property type="entry name" value="PROCESSING OF GAS1 AND ALP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28199:SF1">
        <property type="entry name" value="PROCESSING OF GAS1 AND ALP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07543">
        <property type="entry name" value="PGA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL28300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="190" mass="22068" checksum="F7B7FF7CB0C0D72A" modified="2015-09-16" version="1">MSTPQSDLSEKAAEAANDFFAQLYAFFELVITRFFKNGYASIAQMSGKRWTKVIGSVIFYLILRPYIEKTFKWMHDRDRRKEKEKREKEKAQFGKVKVSPNSLRAGGDSGKGKVLGEVDNTDDELEDEEDLMAAASGVPEWNDMARKRQKNYIKRVKKDQRAEDLSRDQIMELLDWSEEEEVDVKVKKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQC4</accession>
    <name>A0A0G4PQC4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Formyltetrahydrofolate deformylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S028g000132</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793161">
        <property type="protein sequence ID" value="CRL28579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQC4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PQC4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008864">
        <property type="term" value="F:formyltetrahydrofolate deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04875">
        <property type="entry name" value="ACT_F4HF-DF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08648">
        <property type="entry name" value="FMT_core_Formyl-FH4-Hydrolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01927">
        <property type="entry name" value="PurU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041729">
        <property type="entry name" value="Formyl-FH4-Hydrolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004810">
        <property type="entry name" value="PurU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044074">
        <property type="entry name" value="PurU_ACT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004684">
        <property type="entry name" value="PRK06027.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00655">
        <property type="entry name" value="PurU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42706">
        <property type="entry name" value="FORMYLTETRAHYDROFOLATE DEFORMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42706:SF1">
        <property type="entry name" value="FORMYLTETRAHYDROFOLATE DEFORMYLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036480">
        <property type="entry name" value="FormyFH4_hydr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01575">
        <property type="entry name" value="FFH4HYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="3">
        <location>
            <begin position="6"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL28579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="287" mass="31634" checksum="D5C0DFD4E87CA40B" modified="2015-09-16" version="1">MASSFILTLSGPDRPGIVHAVTAFLVQNNLNIIDSSQFGDPASKRFFMRTQFAIASGGDETPELEKLRTAFEPTAQSFSLNFEINPTVKKPRVLIMVSKIGHCLNDLLFRQSTGQLSIEVPLIVSNHPDFATLAATYNIPFHHLPVTADTKAQQEAQILELVSRHNIDLIVLARYMQVLSPTLCTAMSGRIINIHHSFLPSFKGAKPYHQAYDRGVKIIGATAHFVTSDLDEGPIIEQNVVRVNHGMSPKELTHAGSNVESNVLATAVKYVTERRVILNGHKTVVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PR11</accession>
    <name>A0A0G4PR11_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">Diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5 16">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PCAMFM013_S031g000008</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 16">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Endoplasmic reticulum membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5 16"/>
    <dbReference type="EMBL" id="HG793164">
        <property type="protein sequence ID" value="CRL28840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PR11"/>
    <dbReference type="STRING" id="1429867.A0A0G4PR11"/>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF0">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 16 18" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CRL28840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="365" mass="41096" checksum="CFB0F918AAF86FE9" modified="2015-09-16" version="1">MNGETRSAGRASASTSQSSHGRKRIHWAPLNIGLERRLQTFVVLCHTLTIAIFLTSFFFTCAIPLSWPLLVPYLVYISLFSTTATSGHLKGRSPFLRSLPIWKVYASYFPARLHREESLPPTKKYIFGYHPHGIISHGAFAAFGTEALGFSKLFPGITNTLLTLDANFRIPFYREYALAMGLASVSRESCENILTKGGADGEGMGRAITIVVGGARESLNARPNSLRLVLKRRKGFVKLAIRTGADLVPVLAFGENDLYDQVDSDQHPIIHKIQMLVKQTLGFTIPLFHARGVFNYDVGLMPYRTPLNIVVGRPIPVMQQPNRDKINDQYIDELHSRYVEELMRLWDQWKDVYAKDREGELEIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRC2</accession>
    <name>A0A0G4PRC2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S029g000124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793162">
        <property type="protein sequence ID" value="CRL28708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PRC2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PRC2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048869">
        <property type="entry name" value="OCRL-1_2_ASH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF300">
        <property type="entry name" value="TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21310">
        <property type="entry name" value="OCRL-like_ASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="49"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="734"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="943"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="743"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="958"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="988"/>
            <end position="1005"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL28708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1068" mass="117751" checksum="D5BE909FAA4CCA33" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PSI3</accession>
    <name>A0A0G4PSI3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S035g000042</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pseudouridine synthase"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF40">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE RPUSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="178"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="307"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL30135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="574" mass="63313" checksum="FC81C942AB4C71CA" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUR8</accession>
    <name>A0A0G4PUR8_PENC3</name>
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        <submittedName>
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        </submittedName>
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        <name evidence="9" type="ORF">PCAMFM013_S040g000083</name>
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    <organism evidence="9 10">
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Eurotiomycetes</taxon>
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            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
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        <property type="protein sequence ID" value="CRL29857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF8">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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            <end position="343"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="345" mass="36847" checksum="A68DB2B25D2E0E39" modified="2015-09-16" version="1">MSGTMRAAQYNTTLNQVEINEIPIPDPGENDILIKNACASLCHSDLMLFWGHTAEKPPMEKVTIGHENTGTVAAIGRNVTGFKIGDPVGCLGCSYACYKCEGCRVHNLHCVEGTGRLHGFTTHGHFAEYSLSDYRNSMVLPAGMDLATTAPLFCAGITAYHSVKKCGLQEGDWIAIIGCGGLGHLAIQYAKALKLRVIGIDISDSQLESAKSLGADLTFNSASTPGYEKEILSQTSGGVHAAVVLSASNAAYQGAPSVLRINGILMVIGIPKENLSINALDILLGKYRIMGASSGTPQQMREPIEFSYEHGIKAHMTTFNDIGDIQKIIDLLENGKTAGRFGIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVU9</accession>
    <name>A0A0G4PVU9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S047g000005</name>
    </gene>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793180">
        <property type="protein sequence ID" value="CRL30277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PVU9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PVU9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL30277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="77" mass="9274" checksum="BE30CFCE71C98C78" modified="2015-09-16" version="1">MIQVRPDQFISPLTYLEVSPNRKKFATPSRIIQSLRYRYKSSPKIIYIVNDDIKDIFSHILQYLHNQLRNVSFNKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PW73</accession>
    <name>A0A0G4PW73_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S050g000019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793183">
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="49" mass="5317" checksum="4F4E30DB24D34091" modified="2015-09-16" version="1">MADPADNQPSMPPQTPQTPTLAPTPPSSIMGRKGRPRASRLARTRTCSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PWA3</accession>
    <name>A0A0G4PWA3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Prolyl 4-hydroxylase, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S051g000005</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <begin position="71"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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</entry>
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    <accession>A0A0G4PWN0</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            </authorList>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL31330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="465" mass="52158" checksum="8088D65FD780640B" modified="2015-09-16" version="1">MVLFDPDSLVSHGAPGPDISDDELVDWDAWLTPEALHNEKYLATSQCSSINVGDCTERQDLLKHAPQFHSKRPEVPLPSDGSLQLTQSTDSNKETMTIGLRTASPGVYAFAKCGNTEIQPIVINEKEQLKYSKPSEDNFSAFGLGNHHQRRALTSPDLKLLKVQEIERGTFHKYKPVDNRTQVAEYVDCIQTICQIATGETMSAKQARDVEDCGDSLITIIRSDGPIASFKSFLLNCHLPTLPRVDLNSSLTACVSYLRYLNSLTCSVSKSDDMNRRLAQIWIHIHFENHVNDLKESEKNGLPLNRQRRAIPTIARDSILQALHGNQFVPQKTDRDYLSDQCRWGERWWKAATCMGLGVILLASEDLANQIGRRTAFQNKMVDTLAIYVLNRYPALTSLYRSFESMAVDLMLGGDSVFSQDQLNIIQEAPVGNEANSCKLERWVVPNLKSLSGIASSHMIFLQRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NSP4</accession>
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        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">PCAMFM013_S001g000012</name>
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4NSP4"/>
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    </dbReference>
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            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="365"/>
        </location>
    </feature>
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            <end position="830"/>
        </location>
    </feature>
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        <location>
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            <end position="874"/>
        </location>
    </feature>
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        <location>
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            <end position="1227"/>
        </location>
    </feature>
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            <end position="209"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
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            <end position="567"/>
        </location>
    </feature>
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        </location>
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    </feature>
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            <end position="689"/>
        </location>
    </feature>
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        <location>
            <begin position="693"/>
            <end position="732"/>
        </location>
    </feature>
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        <location>
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        </location>
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        <location>
            <begin position="1162"/>
            <end position="1180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL17052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1293" mass="141207" checksum="192A94053EEA5BB8" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NUH8</accession>
    <name>A0A0G4NUH8_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable acetate kinase</fullName>
            <ecNumber evidence="5">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S001g000712</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the acetokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="5"/>
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        <property type="protein sequence ID" value="CRL17752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NUH8"/>
    <dbReference type="STRING" id="1429867.A0A0G4NUH8"/>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00016">
        <property type="entry name" value="ackA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="ACETATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060:SF15">
        <property type="entry name" value="ACETATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000722">
        <property type="entry name" value="Acetate_prop_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="212"/>
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        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="5">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="5">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL17752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="414" mass="45182" checksum="5032FA40AA907B23" modified="2015-09-16" version="1">MPKSILAVNAGSSSVKITFYTFENPPRTIADAAISGITAPPPTLKYQQGDKKHQEEVKEKLSTPQDAFKYLLQRCFSDPDLSEVASVDDLEYICHRVVHGGDYRDAVEINDETIDRLKGLEDLAPLHNFSALEIVRLCKVELPKVRSITFFDSAFHQTIPEATRTYPINQEIAKANGLRKYGFHGISYSFILRSVAQFLNKSIEKTNLVVLHIGSGASICAIKDGKSVDTSMGLTPLAGLPGATRSGSIDPSLVFHYTNEAGKLSPGSTSEMHISTAEDILNKQSGWKALTGTTDFSKIAVENPPSKAHKLAFDIFVDRIQGYIGSYYVKLNGELDGVVFAGGIGEKSALLRRTLVDKCQCLGLAIDDVANDKGPGDEETVKDISKGSSKGPRVLVCQTNEQFEMAYHCACSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NUP2</accession>
    <name>A0A0G4NUP2_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone transcription regulator 3 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S001g000755</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has a role in a nucleosome assembly pathway that is required for the integrity of heterochromatin and proper chromosome segregation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HIR3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4NUP2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000417">
        <property type="term" value="C:HIR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033053">
        <property type="entry name" value="Hir3/CABIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502:SF7">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="362"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1751"/>
            <end position="1778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1800"/>
            <end position="1975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="410"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1851"/>
            <end position="1861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1881"/>
            <end position="1914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1923"/>
            <end position="1944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1959"/>
            <end position="1969"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL17795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1975" mass="222020" checksum="42F53F6E0AA98E70" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NVJ3</accession>
    <name>A0A0G4NVJ3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glycine betaine/L-proline transport ATP-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S001g001032</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="CRL18072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NVJ3"/>
    <dbReference type="STRING" id="1429867.A0A0G4NVJ3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001305">
        <property type="entry name" value="ABCG transporter ABC superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052215">
        <property type="entry name" value="Plant_ABCG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48042">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48042:SF11">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="511"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="608"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="32"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL18072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="632" mass="70292" checksum="252270A23B877263" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NW75</accession>
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        <submittedName>
            <fullName evidence="4">Chromo domain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S002g000197</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4NW75"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18966">
        <property type="entry name" value="chromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="3">
        <location>
            <begin position="39"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="366"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="413"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="885"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1289"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="314"/>
            <end position="330"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL18327.1"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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</entry>
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                <person name="Ropars J."/>
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                <person name="Dupont J."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
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    </evidence>
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    </evidence>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="49" mass="5323" checksum="5A3CBEA60BAC52A1" modified="2015-09-16" version="1">MVAGLPRALSLTRVVEFANDLEKKTTEEITVTFAVGPVREESIEYIGAA</sequence>
</entry>
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        <submittedName>
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        </submittedName>
    </protein>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL19017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="318" mass="34297" checksum="E689B110D6EA5732" modified="2015-09-16" version="1">MIPSTFAPGITRRDTAKSGSGYEGAYGIPPPVVSGGGLLGPQSAGAIYQHIHEMAAKRISTLDYLRKAHEGRVYWFNTVHFSRADIARLPYFEARKLSRRAINYLLLGLSLPTILDVNSTPFEYVRALNALLLEFETFQSVHPPDGSSSSSLARARIPQMFKRATHTGTKTRRASSANEIGLPMQSSDPSDLKNTAGNLGSASSASVTSFPLTESSDLHPGEEYTYLLTPSLPFEPDFFETFATLCDVLIDTYSRLAALVSSPAVCTVALGETFSKADARLRKIMVAGAVREFEDASRNSVKSEVAGVSRVVLGGLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NY92</accession>
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        <recommendedName>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>holo-[ACP] + malonyl-CoA = malonyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="1"/>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL19035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NY92"/>
    <dbReference type="STRING" id="1429867.A0A0G4NY92"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.250">
        <property type="entry name" value="Malonyl-CoA ACP transacylase, ACP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050858">
        <property type="entry name" value="Mal-CoA-ACP_Trans/PKS_FabD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42681">
        <property type="entry name" value="MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42681:SF1">
        <property type="entry name" value="MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="5">
        <location>
            <begin position="48"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL19035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="402" mass="44401" checksum="27BE4CE76A85593C" modified="2015-09-16" version="1">MLSRLSHPRGHLRLGSFVRVASQVLATPSRPTNLNVLPFRRDLHTALFFPGHGVQRVGMANTWIESFPHTAAKVLDEMDSTLGFKLSSIISDGPNSKLNQTENAQPAVMAISVLILRILEQEFGFNTKSRVDVTLGHSLGEFSALVAGGHLGFGDALQLVRGRAEVMAQCTRQLTEQSGETYGMVAILCEPEHLEGLLRTVQEFIGPESPGIEIDRDNRVPSIQRVVVANINSKNQIVLSGSLDRIKILLVQMRQFGGHDPRAVRLKCDSPFHSPAMAPAADYMRDALDKINITFPASIPCISNVSALPFQSEEDIKDLLSRQCTDTVRWWDSIRYLDQERGVRRWIGIGPGKVGRNLVGKEVGRVDTKGGGVWAVCDPREMSEIMAALEQTEVETEDYQPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYH6</accession>
    <name>A0A0G4NYH6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Small nuclear ribonucleoprotein E</fullName>
            <shortName evidence="12">snRNP-E</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Sm protein E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S002g001012</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in pre-mRNA splicing. Binds and is required for the stability of snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site. Involved in cap modification.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL19142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NYH6"/>
    <dbReference type="STRING" id="1429867.A0A0G4NYH6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01718">
        <property type="entry name" value="Sm_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000031">
        <property type="entry name" value="Small nuclear ribonucleoprotein E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027078">
        <property type="entry name" value="snRNP-E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11193">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12 14" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="11"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CRL19142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="87" mass="9973" checksum="F5564C8E17673AF0" modified="2015-09-16" version="1">MAGRKTLLAPIHFIFSLLQKRSTVSVWLYEQLAFRIEGKIRGFDEFMNLVIDDAVEVRLATKTEEEKRRPLGQILLKGDNVSLIQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYK8</accession>
    <name>A0A0G4NYK8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S002g001030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL19160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NYK8"/>
    <dbReference type="STRING" id="1429867.A0A0G4NYK8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL19160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="168" mass="18481" checksum="F5F1AD4A88E6646B" modified="2015-09-16" version="1">MATRTIYLISARNTSFQRAHFSIFVPSATNPDRGTKIHAVGAPMAGYVLEFKRNYNPSLDPHDQTFPIGQVHSSDIVDSPDAAPSIDSTPRGKIELAATQIPTPGINHNFMAPVNDTTNKRCQEWTMEYVRHLVAKGLIDEEAVEIVQSKRDSPGHGIGLRSVTRLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZI0</accession>
    <name>A0A0G4NZI0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S003g000266</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZI0"/>
    <dbReference type="STRING" id="1429867.A0A0G4NZI0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF59">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="476"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="108"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL19475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="547" mass="60373" checksum="5D0969F7264F2B5A" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P002</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the UPF0507 family.</text>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097422">
        <property type="term" value="C:tubular endosome"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24170">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G09870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ank_5"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="563"/>
        </location>
    </feature>
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        <location>
            <begin position="566"/>
            <end position="575"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL19652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1307" mass="146248" checksum="53374A2372913A8F" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0D2</accession>
    <name>A0A0G4P0D2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S003g000582</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P0D2"/>
    <dbReference type="STRING" id="1429867.A0A0G4P0D2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050317">
        <property type="entry name" value="Plant_Fungal_Acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642:SF11">
        <property type="entry name" value="SHIKIMATE O-HYDROXYCINNAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="249"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL19791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="532" mass="58998" checksum="2AA4D97FC35CB30C" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0L0</accession>
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    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S003g000647</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P0L0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL19855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="60" mass="6631" checksum="C04176FBE60B56C5" modified="2015-09-16" version="1">MGRNYVDPFTILPAPDGASPFSVAEGAQAVSKFLHINNMVSRYKIDPSLFGIYPKPFDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-11-27" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0P3</accession>
    <name>A0A0G4P0P3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mg2+ transporter protein, CorA-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S003g000682</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
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        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL19890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="420" mass="47676" checksum="36484B31393BF624" modified="2015-09-16" version="1">MSENLFGVYDFLSAHYAISWGSKGDEDYDPSVMIYALDIASDGSVSKVKLPSGPEVTEVLLVQPQHPTCLAGIKGYRDIIQCVEPNLQTRIVLVDQVTNPIFLETFAHVYEFDREMVMAFMNLWSGHPVSPKYHADLHLPAYKCSKLREQILDLGYGRFAFSKKTKTESDESHEVNVIFIFWNMLEDPGFFDSRERSEPAQDIRPSRDRLFRELHTRLFAHQFPYEFEFPKAWDDRIDEIDHDYAMRFAKRVEVVIRDEQQLEVGRLSLQESKKAIEQANLSIREGKRMKMITILAFVFVPASLSTSVFGMNLRELGSPPVWVFVVTSLAIFAGAFSLWVAVYEFNLAIHIPRARELEGVSLPHRLYLLAWLISHFHLNTFGDTKGGLDAGGANLGSVESTGITVDHILGLQVFTGSFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P113</accession>
    <name>A0A0G4P113_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S003g000797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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    <dbReference type="STRING" id="1429867.A0A0G4P113"/>
    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
    <dbReference type="CDD" id="cd24163">
        <property type="entry name" value="RWDD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059181">
        <property type="entry name" value="RWDD2A-B_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL20005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="137" mass="15331" checksum="E1913A0E4470FB5F" modified="2015-09-16" version="1">MQTLYNALIRTHHITSRKKVAALKRAADTHQCAVLLRSGGCPGIMYVEGGKEPVESWVDVVRRLRYKDFQLVTRPGVVEEEAECGKQGTGNGNWKNKDGKGLDLPLGLDEVESVKEFGGIMAKRGVWNWWRRGMGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P1E3</accession>
    <name>A0A0G4P1E3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
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        <name evidence="9" type="ORF">PCAMFM013_S004g000081</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4P1E3"/>
    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="42"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="680"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL20141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="732" mass="81913" checksum="1330BE31427090E9" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P1L1</accession>
    <name>A0A0G4P1L1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">tRNA-dihydrouridine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S004g000151</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
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        <property type="protein sequence ID" value="CRL20211.1"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:flavin adenine dinucleotide binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
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        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
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        <property type="entry name" value="tRNA-DUS-like"/>
    </dbReference>
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        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="11">
        <location>
            <begin position="43"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="384"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="384"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL20211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="477" mass="51189" checksum="C82391DB2A0BB2D2" modified="2015-09-16" version="1">MIRTLRKTMATLASASATGPAQATVPRVPIPAKGVDYRNKIVLAPMVRSGELPSRLLALKYGADLVWGPETVDRSMIGAERRVNPRNGTIEFTRMPSNGGRPNKPTKESVIYRIDPAREKGRLIFQLGTADPKLAVAAARIVADDVSGIDVNSGCPKPFSTSGGMGAALLRTPDLLVLILETLVKEVGEPHQIGISVKIRILSKPEETEALVSRLVKTGITALTVHCRTTPMRPREAAIRDQLPMIASICHQAGVACVMNGDVTSRDQGLALMKEYGVDGAMIATSAENNSSCFRAKEDGGLAPWREVVYEYLRFCIQSENRLGNTKYLLNMLIPGKDKEFKDTKLCKTYLDICRGLKFDDLLPAAASLDQILGLDDKWEVAPNVTSNPTLSELDTPTQPEPKSKAVQHAMESETARAAGGSAVRTKAPLPAVHGGGPIRRSSAPQPAKVTKVDAEQPAVEAPIPAAPTEAPSQVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P1X3</accession>
    <name>A0A0G4P1X3_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-galactosidase</fullName>
            <ecNumber evidence="2">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S004g000244</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="2"/>
    <dbReference type="EMBL" id="HG793137">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
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        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004352">
        <property type="entry name" value="GH114_TIM-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35273">
        <property type="entry name" value="ALPHA-1,4 POLYGALACTOSAMINIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G07890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35273:SF2">
        <property type="entry name" value="ALPHA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside-hydrolase family GH114 TIM-barrel" evidence="5">
        <location>
            <begin position="83"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL20304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="323" mass="34987" checksum="B33A7157E5EFD01B" modified="2015-09-16" version="1">MGDLPSKTGWWAWSTKKKVLIFGTVALVIVALGVGLGAGLGIGLKNGGDDDNDNDNEGTGSGTTNTTTPTNTTVKWQPAVGTKWQIILKSGDGAPISTSVDAPIYDIDLFDNNKTVISDLQKMGRKVICYFSAGSFENWRDDAGDFNSTDKGEDLDGWPGEKWLNVTSPNVRKIMQARLDIAVEKGCDGVDPDNIDGYDNENGLNLTKAQAINYVNWLASQSHSRGLSVGLKNGAGIIDSVIDNMQWCVNEQCAEYEECDTYAPFIQADKPVFHIEYPKGDSTNNNKSVTTNQAKSACTANSSGNFSTVIKNMDLDNWVEYCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P204</accession>
    <name>A0A0G4P204_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S004g000280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P204"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="191"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL20340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="256" mass="28720" checksum="E0ED3BD76DE59A0F" modified="2015-09-16" version="1">MAATTQENLLEDEEANMDNVTVAKPYTSLPPSQAPCALVAPYASRMLAALVVVVAVERQHRASNYYRSLCILEAYSHMLSRDSPDHETKEPMFPEGCEPSSVAKPDTACVPSSLRPATDDNANVNADANIETNNGEETPDVDKKPLEPRLPARTTSPTTTALKAVLLRSRVSLNDEEKKHGEKAAPESNEILRAKDKVDTLKIRLEDVKWEYERAKAEFEAYEQERVAFRTRHRKLDEAEKELEELCHSQETQEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2D4</accession>
    <name>A0A0G4P2D4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Initiation factor eIF-4 gamma, MA3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S004g000348</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P2D4"/>
    <dbReference type="STRING" id="1429867.A0A0G4P2D4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000050">
        <property type="entry name" value="Nuclear protein (Sgd1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF4">
        <property type="entry name" value="NUCLEOLAR MIF4G DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="5">
        <location>
            <begin position="654"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="817"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="142"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="236"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="267"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL20408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="892" mass="100266" checksum="168BDE5E93012BD6" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P315</accession>
    <name>A0A0G4P315_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S004g000657</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P315"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL20716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="174" mass="20272" checksum="D10121BC99BCCC69" modified="2015-09-16" version="1">MTALDACLMLVAVKQKLMRTRRDLLTELSAEEQNDEQFEALLWNKVKHKEVSSKLRTSILTSTLTSEINSVPHRFEYKANKGKVTGSNPIQVLNDAQLEHLTRLRIRATERAQQSEWIQETFAHAISHVDIAIATNEHCYQVLVDLKERQRLLHQLASEEYHDEQLEREIWDQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3H5</accession>
    <name>A0A0G4P3H5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S005g000018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL20854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P3H5"/>
    <dbReference type="STRING" id="1429867.A0A0G4P3H5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL20854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="89" mass="9457" checksum="57231AD153D045FC" modified="2015-09-16" version="1">MYDESPINIPSLSSLCVSVPCPMPTLGVVIFRGSSFLIGLGTSSYPEYAPSLFTINDALGSSFAAGVVLLGRPLYFNKGWGRVAPRLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3S5</accession>
    <name>A0A0G4P3S5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S005g000155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL20991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P3S5"/>
    <dbReference type="STRING" id="1429867.A0A0G4P3S5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="44"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL20991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="134" mass="15253" checksum="CD28D879FC88F81D" modified="2015-09-16" version="1">MQEFHLEHKKYIIFFLHIHDVSDNCLTFSFPHPQRCLLVLAPAELEGPLLSHSSIPDVTLIGVPDINMARKGLPRAYVVVDQGRITPGAIKSFVKDNLASHKRLRGGVIFVSEIPRVRLARSFEGNCARWLRWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P425</accession>
    <name>A0A0G4P425_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="14">SNF2-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S005g000244</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P425"/>
    <dbReference type="STRING" id="1429867.A0A0G4P425"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031010">
        <property type="term" value="C:ISWI-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Cheeseman K."/>
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                <person name="Dupont J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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        </source>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
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                <person name="Abraham A.L."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
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        <source>
            <strain evidence="18">FM 013</strain>
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        <text evidence="13">Sorting nexin, involved in the separation or division of vacuoles throughout the entire life cycle of the cells. Involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network, for cytoplasm to vacuole transport (Cvt), and autophagy of large cargos including mitophagy, pexophagy and glycophagy.</text>
    </comment>
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        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Preautophagosomal structure membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P4F0"/>
    <dbReference type="STRING" id="1429867.A0A0G4P4F0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07628">
        <property type="entry name" value="BAR_Atg24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06863">
        <property type="entry name" value="PX_Atg24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000035">
        <property type="entry name" value="Sorting nexin-4 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000042">
        <property type="entry name" value="Vacuolar targeting protein Atg24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949:SF2">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="16">
        <location>
            <begin position="71"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="397"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00054950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CRL21157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="494" mass="56280" checksum="73D707C911D994F7" modified="2015-09-16" version="1">MDQHDDFDSVSWKHDPDSDVSRPTTASTDAAEPSEIHHDSNGKRRMSSAQEEPQAGPLADAVDLAGIGDGVLECQVDSPLKENDGTKDAYISYLVTTHTDFKSFQKPEFTVRRRFTDFYFLYKTLYREYPACAVPPLPDKHKMEYVRGDRFGPEFTTRRAWSLHRFLKRLTLHPVLRRAPLLTIFLESPDWNAHMRLHSTRVSTNTGSDGAATGIFDNFTDSFVNAFSKVHKPDRRFIEVREKADKLDEDLSHVEKTVARVARRESDLETDYAELATQFRKLVPLEPAIEMPLQVFAASVEETARGMRGLKDHTDQNYLGSLRDAESYIMSLKSLLKTREQKQLDFEALVDYRNKAVTERDSLAANPAAYYASNPLTSSPASFIRSKMEDMRGVDHEQSRRERVRKLELRIDELTREVESAKTTSEMFDEEVIREVADFERIKAVEFRDGLGSFADSHIEFYQGVLSTWERFVAEMEGEAEPGHDSDAAAIGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P4M6</accession>
    <name>A0A0G4P4M6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pectin lyase fold/virulence factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S005g000449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P4M6"/>
    <dbReference type="STRING" id="1429867.A0A0G4P4M6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000023">
        <property type="entry name" value="Exo-beta-1,3-glucanase Exg0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000026">
        <property type="entry name" value="Exo-beta-1,3-glucanase Exg0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039279">
        <property type="entry name" value="QRT3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928:SF2">
        <property type="entry name" value="PECTATE LYASE SUPERFAMILY PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928">
        <property type="entry name" value="POLYGALACTURONASE QRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="1">
        <location>
            <begin position="102"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="1">
        <location>
            <begin position="453"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL21285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="817" mass="85804" checksum="9CFE9EF85AEAA618" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P503</accession>
    <name>A0A0G4P503_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S005g000541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P503"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL21377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="57" mass="6383" checksum="61B02B139DF2AA7E" modified="2015-09-16" version="1">MGECAVWHASKKIKRLMVIVRGGKSFLGGENDWKLSQVTGWFLPLETPTHAFEPALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5P8</accession>
    <name>A0A0G4P5P8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S006g000178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P5P8"/>
    <dbReference type="STRING" id="1429867.A0A0G4P5P8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL21638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="527" mass="59844" checksum="73ADB8B8784D356A" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5Q0</accession>
    <name>A0A0G4P5Q0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S006g000180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P5Q0"/>
    <dbReference type="STRING" id="1429867.A0A0G4P5Q0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL21640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="87" mass="9931" checksum="C21D81A4D94A8097" modified="2015-09-16" version="1">MCDNQQTVDLLTKEGATMHTKLRHVDINRCWMKQEVSAGRVNVDWVPTAAMPADGLTKALPKQKQHLFREMIGMREISHLICKTEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5W0</accession>
    <name>A0A0G4P5W0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pyridoxal phosphate-dependent transferase, major domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S006g000241</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P5W0"/>
    <dbReference type="STRING" id="1429867.A0A0G4P5W0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF77">
        <property type="entry name" value="8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="56"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL21701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="432" mass="47202" checksum="E079867654E3CA99" modified="2015-09-16" version="1">MVASQPKTSSTSSTSSTSSTSSSAPKTLIDSLSAALSRREAKSVRRRLTVLPRTAVDFSSNDFLSLSTSSAYRERFLALLNNTPPSFPLASGGSRLLDGNSAYAEELENFVAEFHQAPTALLFNSGYDANVGVLSSIPQPGDVILYDELIHASAHEGMRLSRAGPRKMFAHSSPIGLREALQSQIAEDPAIAEGTRNVFVLIESIYSMDGDVAPIKEFIAVVDELLPHGNGYFYVDEAHATGVFGPRGAGVVQELGVQDRMFIRVHTFGKALASHGAMVLCGPETRDYLINYARSLIYTTALGFPFLASIRAAYELLSSGETESLQRRLQELIRHLRQQLDGLHTYQSVMFEVDHFPTSPIISLRTSQPRQLASLCQESGFIVRAIMPPTIPEGKERVRVCMHAGNTEGEIDGLTRIIQSWLDQSHRNASKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5Z2</accession>
    <name>A0A0G4P5Z2_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphotransferase</fullName>
            <ecNumber evidence="11">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S006g000276</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="11"/>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P5Z2"/>
    <dbReference type="STRING" id="1429867.A0A0G4P5Z2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000004">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF16">
        <property type="entry name" value="HEXOKINASE TYPE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 11 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="12">
        <location>
            <begin position="22"/>
            <end position="217"/>
        </location>
    </feature>
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        <location>
            <begin position="223"/>
            <end position="460"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00047905"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL21736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="476" mass="53303" checksum="B12FF8197FA33EB1" modified="2015-09-16" version="1">MQGIRYRPELMEGLPEALITELKKYEDWFLLEPPKLKAITEHFARELEKGLTVEGGSIPMNITWIMRYPTGQEKGRILTVDLGGTNIRVCDVCLSAGRRDFEQRQRKYKLPEEVKTTTKEALWGFIADRIGSFLTDSHCEISASDPLPMAFTFSFPVEQKSIRSGVLQRWTKNFNVSGVVGHDVVPQLEEELAKRNVPVKLVALINDTAGTLVASRYRDPQVKIGSIFSTGCNAAYMEECRLIPKLRDSGLPEDATVIINTEYGSFDNERKVLPLTPFDRQIDEESAHPGRQIYEKMVAGLYIGEMLRLVMLKMHEEGVLFKGQDVSRLRTANSLETSFLSSVEMDMSESLTDMKEEFKESLNLELSLHELKACRHLIGLIAMRAARLYACGIAAICLKKGIRQCHVGVDGSVFSKYSMLKGRATQGLRDIFDWDSGRLDLIALNSAEDGSGVGAALVASLTMDPSELKDCNMEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6B6</accession>
    <name>A0A0G4P6B6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SET domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S006g000403</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053209">
        <property type="entry name" value="Gramillin-biosynth_MTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
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        <location>
            <begin position="201"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="351"/>
            <end position="545"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL21863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="748" mass="84349" checksum="B491A7670928234A" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6P1</accession>
    <name>A0A0G4P6P1_PENC3</name>
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        <alternativeName>
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        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S006g000419</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4P6P1"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="30S ribosomal protein S9"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023035">
        <property type="entry name" value="Ribosomal_uS9_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
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    </dbReference>
    <dbReference type="NCBIfam" id="NF001099">
        <property type="entry name" value="PRK00132.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL21879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="307" mass="34026" checksum="BDACB78340EB50C6" modified="2015-09-16" version="1">MAWHKPTSLAQAMQSLRLTSTLTKPSTQASRTTLNTLRTRTYATEAESVPAAAAPEINFGSFNQKPARIIPSSPSYFSGSPRFIDHVLALEALQAKHAALPIVATSEAPRMAWFKLPQFRDYVGEPVPMKKYKSLVKILQRLNRIQPDMLPAEVRDTLATFLRPGNPYAVENVPRTVDENGRARGKGKRKESTAVVQLVEGEGEVLVNGKSIVEAFKRVHDRESALWALRCTQRLDKYNAWIRVQGGGVTGQAEAITLALGRALLLHEPGLKAVLRKAGAITVDARRVERKKPGHVKARKMPTWVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7V2</accession>
    <name>A0A0G4P7V2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger, Rad18-type putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S007g000353</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P7V2"/>
    <dbReference type="STRING" id="1429867.A0A0G4P7V2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15761">
        <property type="entry name" value="FYVE1_Vac1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15737">
        <property type="entry name" value="FYVE2_Vac1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021565">
        <property type="entry name" value="Rbsn_Rab-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036531">
        <property type="entry name" value="Rbsn_Rab-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
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        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rbsn"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140125">
        <property type="entry name" value="Rabenosyn-5 Rab-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="8">
        <location>
            <begin position="196"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="8">
        <location>
            <begin position="335"/>
            <end position="413"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
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        <location>
            <begin position="535"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
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            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
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        <location>
            <begin position="543"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL22372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="674" mass="75016" checksum="F3D139FAA7D3A897" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7X4</accession>
    <name>A0A0G4P7X4_PENC3</name>
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        <recommendedName>
            <fullName evidence="13">NEDD8-conjugating enzyme UBC12</fullName>
            <ecNumber evidence="11">2.3.2.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">NEDD8-conjugating enzyme Ubc12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">RUB1-conjugating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Ubiquitin carrier protein 12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme E2 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PCAMFM013_S007g000414</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.</text>
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        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the ubiquitin-conjugating enzyme family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="UBC"/>
    </dbReference>
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        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 17" id="KW-0833">Ubl conjugation pathway</keyword>
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        <location>
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            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="16">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CRL22433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="184" mass="20740" checksum="DE41FEAD2FB44178" modified="2015-09-16" version="1">MLKIWSMKQKQQEAENAEGAAGKKKKKVTAAQLRVQRDLQELTLGSTMKMSFPNPDDILNFTLTIEPDEGMYKGGVFNFSFAVNQNFPHDPPKVKCTQKIYHPNIDLEGNVCLNILREDWKPVLNLNAVIVGMQFLFLEPNASDPLNKDAAEDLRATRDAFKKNVRNSMAGGSVRGISFERVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P802</accession>
    <name>A0A0G4P802_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S007g000370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P802"/>
    <dbReference type="STRING" id="1429867.A0A0G4P802"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="462"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="526"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL22389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="575" mass="61830" checksum="8A9A07A609FDBC42" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P8D3</accession>
    <name>A0A0G4P8D3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative amidoligase enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S007g000546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4P8D3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022025">
        <property type="entry name" value="Amidoligase_2"/>
    </dbReference>
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        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847:SF1">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12224">
        <property type="entry name" value="Amidoligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL22565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="348" mass="40804" checksum="135B75480A92264E" modified="2015-09-16" version="1">MARYSFYFGVEIELISEPHEVRYPLDRSFYYKKLAKSLRSHGLDAKADSLEERYRKHSEHYDKWFLTQDGSLGTPDYPAKAVSPVLSTMADWQTEINLFWTSWDSVFETPRRSAKCGSHIHVSPWPNKRFTMTELKNIACSIVFYADNLNDMLPSPRRNNTYCQNNWETSLVGLMYKSGSKKDVRQTMERIWKINDEGELKRFMQEDRRVMWNFEHIVPGARFTGTIEFRGGRGLRGPNRTKWWIAFVVSFIQLCISSKRFPYKSPSNRPQTDHFWQKIERYARTIDVEDDLPPDWRDLNESYSSQHWEDTGDNDSDEDKSDTSSTESTSSSESSDLDSLDVEYSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P926</accession>
    <name>A0A0G4P926_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S008g000239</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793141">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P926"/>
    <dbReference type="STRING" id="1429867.A0A0G4P926"/>
    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="467"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="623"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="624"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL22810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="668" mass="75523" checksum="BB188FF417750B9A" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P9A1</accession>
    <name>A0A0G4P9A1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate/purine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S008g000288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4P9A1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034094">
        <property type="entry name" value="Mak32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098:SF2">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="1">
        <location>
            <begin position="31"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL22859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="394" mass="43625" checksum="91CCA5E73B83F29B" modified="2015-09-16" version="1">MVAQDQPIEVEFCTLGMFIIDDIDFGGSRPSVKNILGGAASFAVVGARLVSGSKYARSVSWIVDVGSDFPAETLDVIKSWNTACVFREDPSRLTTRAWNGYHPDEKRDFKYLTPKLRLEPEMLSDSQVWSKTFHMVCSASRCMSIVHDILQRRDELQKAGKAPSAAHASKRPIFVWEPVPDLCTPEEQDKFFAANKVVDVVSPNHMELGMMFEHPGWTEKSQVGQQLVQRITDSGIGPDGNGMLVIRAGKDGSYAYSKSGKIWLPAYHLPDASGATPVIDPTGAGNSFLGALAQGMVTEGREPFQVIGSVLSNSETWKKARDSWGDYQHYPMALICATVAAGFVVEQIGVPQIDVDGNGKELWNQTEFTERVRLYTQRLLRTLEESPQRHLLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P9B8</accession>
    <name>A0A0G4P9B8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S008g000303</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P9B8"/>
    <dbReference type="STRING" id="1429867.A0A0G4P9B8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38167">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38167:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL22874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="183" mass="20434" checksum="7043CFFFD35F56FC" modified="2015-09-16" version="1">MPVPEEEPDNLPLLLEAIKNQPIHRLEGILQDIVKHSPEGRKIASKWLLAAKNDVKSEPAAPVSPLAPVTSALPAKEESMANVPMTSRFESCIYCLEDFEVTQNSETSCKYHPEPDVVDEEYFKAEIAAGYDVDSDEYRLAWPEGFFYPCCGMGLTGKMCQVGWHKAADPDARPRKRTHRSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P9U3</accession>
    <name>A0A0G4P9U3_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="16">3.2.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Exo-1,3-beta-glucanase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PCAMFM013_S009g000023</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="16"/>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P9U3"/>
    <dbReference type="STRING" id="1429867.A0A0G4P9U3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
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            <end position="367"/>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">FM 013</strain>
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            <begin position="436"/>
            <end position="595"/>
        </location>
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        <location>
            <begin position="783"/>
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        </location>
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        <location>
            <begin position="1"/>
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            <position position="1213"/>
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        <source>
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                <person name="Conseiller E."/>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
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        <text evidence="2">Monomer.</text>
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        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
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        <property type="protein sequence ID" value="CRL23551.1"/>
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        <property type="entry name" value="ER"/>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANS-ENOYL REDUCTASE STHE"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-0521">NADP</keyword>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="20"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL23551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="362" mass="39149" checksum="060F5C5D6A0CFBDE" modified="2015-09-16" version="1">MAARDELPSNQTGIIQHEGGILQITHDLPIPELEPHQMLVKTAAVALNPCDYKMPMRFPTPGLWDGCDFSGTVVALGSKVAAQGRFRLGDQAFGAVQGSNMSDPMSGAYCDYIRTEPDLTFHVPKEMDLVNAPSLSGTAIATLGVALFWSLQLPGELHIPASKPEDVLVYGGSSTIGLLAIQMVKLCGHRVITTCSPHNSDLVKSYGADLVFDYDSPTCAEDIRAATKNTLRYALDPFAEAKTLRMCYAAIGRTGGRYCALEQYQESLCSRKTIKHELVMGGAISGRGVELPDPYGIPPRPEIGVWARSWYAELQKLIDNGKLKACPIQTIPGKFEGILVGLDMLRNGKVSGKKLVVPMTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PB78</accession>
    <name>A0A0G4PB78_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid/polyamine transporter I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S009g000485</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PB78"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
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        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
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        <property type="entry name" value="Amino_acid_permease_fungi"/>
    </dbReference>
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        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00913">
        <property type="entry name" value="2A0310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF4">
        <property type="entry name" value="ARGININE PERMEASE CAN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="463"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="57"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL23545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="552" mass="60200" checksum="4CCE360813ECDBFC" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBS6</accession>
    <name>A0A0G4PBS6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MARVEL-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S010g000201</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PBS6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PBS6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451">
        <property type="entry name" value="MARVEL DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="6"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL23763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="165" mass="18073" checksum="9234AB71DE00EC95" modified="2015-09-16" version="1">MLSWIYPLRIVQAILSLATIGLTAYEIASLYDEWSYSNVIYYMLFNGCWTTAIAIPYLGLAPLRFPRFSHEIAIPLIELLTGGLWLSGWIALAVMIPSPGVCHYASCHALQALIVVGAIQWATFVVTNTFAIIDLKNSRRNAKNHRDDAAPEMTGADAATADAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PC88</accession>
    <name>A0A0G4PC88_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S010g000322</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PC88"/>
    <dbReference type="STRING" id="1429867.A0A0G4PC88"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000261">
        <property type="entry name" value="NADPH-dependent 1-acyldihydroxyacetone phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF15">
        <property type="entry name" value="CHAIN DEHYDROGENASE_REDUCTASE (AYR1), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL23884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="298" mass="33031" checksum="A055C9DB8712BBFC" modified="2015-09-16" version="1">MSETTDTRRSVLITGCSPGGIGNSLAREFNRNGLRVLATARDAATISELADLGIETLSLTVDDPENVKLCFADVQKRLGDKGLDYLVNNAGRNYTVPAMEVELAEVRQTFETNLFAVITMCQTFLPLLIKAKGTIVQIGSVAGIIPYVFGSVYNASKAALHSFSDTLRVELAPFGVHVTTIVTGGVQSRIARTDRSLQPGSLYSPIEDEYLTRVKHSQHNAMPNEAYARSVVSQVLYGSAPWRWLWPWARGRKTWIWEGRASWLIWMLSGGWAWSGLFGRVMTKMFKLWKIKDALGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PC94</accession>
    <name>A0A0G4PC94_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Octicosapeptide/Phox/Bem1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S010g000369</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PC94"/>
    <dbReference type="STRING" id="1429867.A0A0G4PC94"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051130">
        <property type="term" value="P:positive regulation of cellular component organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06890">
        <property type="entry name" value="PX_Bem1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11878">
        <property type="entry name" value="SH3_Bem1p_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11879">
        <property type="entry name" value="SH3_Bem1p_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000093">
        <property type="entry name" value="Protein kinase activator Bem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000184">
        <property type="entry name" value="Protein kinase activator Bem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000250">
        <property type="entry name" value="Protein kinase activator Bem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000041">
        <property type="entry name" value="Protein kinase activator Bem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035550">
        <property type="entry name" value="Bem1/Scd2_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035548">
        <property type="entry name" value="Bem1/Scd2_SH3_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035549">
        <property type="entry name" value="Bem1/Scd2_SH3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051228">
        <property type="entry name" value="NADPH_Oxidase/PX-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706:SF2">
        <property type="entry name" value="SH3 AND PX DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706">
        <property type="entry name" value="SH3 MULTIPLE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="43"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="153"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="6">
        <location>
            <begin position="311"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="7">
        <location>
            <begin position="515"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="432"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="457"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="469"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="483"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="499"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL23931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="592" mass="65866" checksum="56C0911FA16D28CA" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCH2</accession>
    <name>A0A0G4PCH2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S011g000019</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PCH2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PCH2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="8"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL24025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="316" mass="34979" checksum="F1F112A8364E43F3" modified="2015-09-16" version="1">MASITRPVVAIAGATGHLGKHVTTAFLSPSFQDKFSEIILLSRNESCLFQPSSSQSGVKLTTRRYNETNLEESLQGVQILVNTIGPAGHDFKTKIAAALPQTNIRVYFPSEFGVDHYGHDFAHLEWNEKKKHLMNAQRVVSHMNIKICRVFCGLFLEDSIGPWFGLDTQNGKYTSVGSSRTPVSFTSLRDVGRTVASLATLPAEKIPDVVHVGGDSRSIVEIAGIMESAGAGRIDIDCLPYEKYKKETTVEPSWRPAAYLWFLMGDGGIAHTPAFLGDDNELVNPGQRLWRWKTVEDLAKETNGQPVKDVVWPRHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PD58</accession>
    <name>A0A0G4PD58_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S011g000216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PD58"/>
    <dbReference type="STRING" id="1429867.A0A0G4PD58"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618:SF1">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL24222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="476" mass="53172" checksum="A42FDC2D0AE381D0" modified="2015-09-16" version="1">MGEETAKPSGRKRGRPRTVANEQEVPERRRKQLRLAQQAYRKRKETTIGNLQNRVHELETGIENISQSFLSFSSLLIEEQLLSQYPHIASALQNITQQCVSLAKAGSDDPSEGALVQAAEEFQIPNNNTAPTPVLDSAYSEASTDAEDITRSVAMRWPAPPTPPYEGQSILPFDLVMPSPTVQFSQFSHITPPLSNSPTLDLLSSNITPDRQWNIAQRLVRTCCQGGYRLLVDNPNSPAVPRVFGSVPSLPERNRMISAFYAVMQDKTGALIDAKTRVLHALQTNMHQTNMHLFSNEQLQVPSKIWQIALESASGDWMDASGVQECLRDKRVILDNFSDSSGRLDYSVSASLDSTAFIKSLSKEATCVGNGPVFPRQSVEKALRLATISVPWDFDNIYLFNRWDDTGNSYNVTRILTPESTLYGKSYELYGQVYLGAANSVRREIMAGFCAMLKWSNARDEYNAVHDRLMLLILFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDN9</accession>
    <name>A0A0G4PDN9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S012g000021</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PDN9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PDN9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03357">
        <property type="entry name" value="LbH_MAT_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051159">
        <property type="entry name" value="Hexapeptide_acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416:SF23">
        <property type="entry name" value="ACETYLTRANSFERASE C18B11.09C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416">
        <property type="entry name" value="SIALIC ACID SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Maltose/galactoside acetyltransferase" evidence="4">
        <location>
            <begin position="26"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL24412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="233" mass="25611" checksum="DA028E98F4C22CD1" modified="2015-09-16" version="1">MAATEKRPEIIELARGLAGVPLCEDYECMISGMMYNPNVPKLLEARHLCRGLAADFNNLDTKTVAYDKIGDKRLELLRKLVGKVGDGTFIEPPFLPDYGCNTVIGKDCFFNWNVTILDTSLVVIGDRVQIGTGVSIITAGHDTSILSRRKFVEFGHPIFIEDDCWIGSNVIILPGVRIGQGSTIGAGSVVTKDIPPFSVAVGTPCRVKKTIPSAEEEEQDPNNQYRNLTREDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PE57</accession>
    <name>A0A0G4PE57_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S012g000171</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PE57"/>
    <dbReference type="STRING" id="1429867.A0A0G4PE57"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF194">
        <property type="entry name" value="INVERSIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="4"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="141"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="352"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL24561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="492" mass="54285" checksum="10663F27DA9009A2" modified="2015-09-16" version="1">MPGIENLPTELILLIASCLPSESSLAALGLSSQGFYRICNPCLYQYNVLHGNSSALDWAVVNGEMDTLQKALDAGAPLLKEQAKGKLRRQSGRFPQFGLQARRTFREFQPHPISLAASAGHENVVRYMIDRGVSANVSTPEGHTLLALAAIHGDASLAKYLLDVGARQGIRSFVGHWPVWIAAFEGNADVVDVLLSAPKQNANEPDKEELMTDALFAAVIAAQVPVVQLLFTHGVQVDVLARFDDTPLLMPANDKDSNFVPLQIVAPGEEPDLILHQNRPQPHAPLIMAARQGQEELVRMLVPGTGSLNRTKALAYAVSCRNREILEILLQGGASPQFCLSDIPDSSEYREEWVQPLFSAVQSNDREFVGLLLDYGADVDVRSPQQYIHRSDRPFEHALLWAVDEVKESMVNLLLERGADPDITDMLGQPALTYAIFSQNEAIVRSLLDHGANPYEAKDDCGRKLTGFWPMSESTWRLLQEAEIKWTKDHPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PEG1</accession>
    <name>A0A0G4PEG1_PENC3</name>
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        <submittedName>
            <fullName evidence="5">Homocysteine S-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S012g000330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PEG1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PEG1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11103">
        <property type="entry name" value="SLR1189 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11103:SF18">
        <property type="entry name" value="SLR1189 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1 3 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="4">
        <location>
            <begin position="5"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL24720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="317" mass="35391" checksum="46E339C74AFD45D6" modified="2015-09-16" version="1">MTSQSQFLPHLTSSKLFLTEAGIETTLIYKRNIHLPSFSTLPLLSTEEGIEALVSIYRDYINVALAHSTGIVLETRTWRGSPSWASELGFSIPQVLDLNRTAVNILQDLRRECQTPPTPIVISGTLGTLRDAYKDSTISFSQAQENYRSQVHVLADEGVDMLSIMTVTNLNEGIAAITVAREFNLPIHVSFSIEIDGRLRGGRTLDDVIREVDRLTENYTTYFGVNCAHPRHIMTALRDLPKDVRLRIGSIRGNASLKSHEELDNTLVLDRGDVSVYVREFFELLNLLPELKVVGGCCGTDEEHLETLVKKVNSFSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PFX0</accession>
    <name>A0A0G4PFX0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S014g000114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S12 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PFX0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PFX0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF14">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="58"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL25218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="521" mass="57535" checksum="B604AC4B29BF4269" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PG80</accession>
    <name>A0A0G4PG80_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">holo-[acyl-carrier-protein] synthase</fullName>
            <ecNumber evidence="1">2.7.8.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S014g000176</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.8.7" evidence="1"/>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PG80"/>
    <dbReference type="STRING" id="1429867.A0A0G4PG80"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055066">
        <property type="entry name" value="AASDHPPT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050559">
        <property type="entry name" value="P-Pant_transferase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215:SF10">
        <property type="entry name" value="L-AMINOADIPATE-SEMIALDEHYDE DEHYDROGENASE-PHOSPHOPANTETHEINYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215">
        <property type="entry name" value="PHOSPHOPANTETHEINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22624">
        <property type="entry name" value="AASDHPPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4'-phosphopantetheinyl transferase N-terminal" evidence="4">
        <location>
            <begin position="64"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="4'-phosphopantetheinyl transferase" evidence="3">
        <location>
            <begin position="169"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL25280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="433" mass="48443" checksum="43F6F9FF9599B7EE" modified="2015-09-16" version="1">MHYTQPFPLHAGLFTSLLVEASMPLKMQLGVPELTKMAPNEIKQNDIFKDQPTLVRWYIDVRHWDEKYSDLPFIQTLTQSDQTAVKKYYQTSDQRLSLASQLLKYYYVHQVTGIPWNKIEIQRTPIPENRPFYDSSLDFNVSHQAGLTIFAGTRAATAHSTSGSQGLPRVGIDIACVDEPSRRRTNRPPKTLADLATFVNVFSDILSFRELATIKNPYATLKLARELGLRKSDPSKDNEEVLATYGIRLFYSIWALKEAYLKMTGDGLLATWIKDLEFTNVIPPEPVRKLGATGRPPTAHSVQNWGRPYSDVKITLRGIAVHSVRVQLVAFESDYIVATAASGPNIGAVSRQVVVNDGDHYLPGCITALDPEKEPQNVRIAPLALRTVGDPDPWCADSEISDPWLPMQEVDIDIDIGPCAEGRCEHARNVPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGE2</accession>
    <name>A0A0G4PGE2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S014g000258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PGE2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195518" evidence="2">
        <location>
            <begin position="23"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL25362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="352" mass="36746" checksum="FE0F33D360F5A3B9" modified="2015-09-16" version="1">MGFVRLSVLAQALLLSLANADASNLNPKGNGCVNPSGYLQCYQKNIDQLSDCMTNAKKTCDGDSLQECELACGNVQLAANIGCWLTDCWNEVYSCAYQGTALQYLEGADRVQGSLDIPYYPAPDNAPGGCGYVWGNFTVTYVQQSNVCEAYDIVSAGLSTATSCECCLESSILSNIIETCPHNDLSDLSIDIMVKSFELGYNQSASDNCSILDDDTGSQCISSFSIDSDASTWYNPGQLPSGFPGTAPLSDTTDAGSLTSAPDPYTFSLFPAYTSVITPAPYNAKAVTTINTGTAVQTGTGTGTESIATGTGSASSSTTSKGAAKNIVSPISSELGVWGIAIYTMAFVIGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGI1</accession>
    <name>A0A0G4PGI1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S015g000027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793148">
        <property type="protein sequence ID" value="CRL25441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PGI1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL25441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="85" mass="8875" checksum="05139CD2DDD5C1B8" modified="2015-09-16" version="1">MTLVPEVEVQDPRSYFGLPGGHLAPGSGFFAPRNRIEATGSKMAPRAKPSFPGLIELGPGNLKSVYRSCVSPGKYSLAPGATSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGS7</accession>
    <name>A0A0G4PGS7_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TBP-associated factor 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Transcription initiation factor TFIID subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S015g000058</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793148">
        <property type="protein sequence ID" value="CRL25472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PGS7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PGS7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22931">
        <property type="entry name" value="HFD_TAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08050">
        <property type="entry name" value="TAF6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000033">
        <property type="entry name" value="Transcription initiation factor TFIID complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.770:FF:000003">
        <property type="entry name" value="Transcription initiation factor TFIID complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.770">
        <property type="entry name" value="TAF6, C-terminal HEAT repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037796">
        <property type="entry name" value="TAF6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011442">
        <property type="entry name" value="TAF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046344">
        <property type="entry name" value="TAF6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02969">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07571">
        <property type="entry name" value="TAF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="8">
        <location>
            <begin position="3"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00076308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL25472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="442" mass="48363" checksum="6880595A44EBF416" modified="2015-09-16" version="1">MSVWNPDNIRDVAESVGILNLNNDVTENLARDVEYRVAQVLEEALKCMRHCKRTVLTTQDIALALRNLDVEPLYGYDSTRPLKFGEASLGPGQPLFYVEDEEVDFEKLINAPLPKVPREVSFTAHWLAVEGVQPSIPQNPTAADSRNLELVSKGPNANSTLAAISGTGDVAVKPLVKHVLSRELQLYFEKVCSAFLHETSEDYRTSGYSSLREDPGLHQLVPYFVQFIAEKVTHSLKNVFVLTQVMHMAEALVQNQSLYVDPYIASLVPSILTCLIGRQLGGTADLVESFALRDMAASLLSLIATKYSHSSHMLKPRLVRSCLKTFLDPSKPFGAHYGAVIGLQSVGGSEVIRVLVIPNLPEYTKLLSDGLDDAARRPAAERVLNALVAVLASLRGSQPLLTNGHAVTDDLRSKLVDKVGDIIAARIVEAGEVQLAHIILEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGT0</accession>
    <name>A0A0G4PGT0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S015g000170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793148">
        <property type="protein sequence ID" value="CRL25584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PGT0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PGT0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195332" evidence="3">
        <location>
            <begin position="20"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL25584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="247" mass="26190" checksum="70B2747269A5285D" modified="2015-09-16" version="1">MILCTFVLTLLVTSNATRCYTPDGYAVEDERYMPCIAIDGVESMCCRLNDTNPDTCLSNGLCWTQSGYWRDFCTNQTWTSPNCLAKSTCSTEEGGNSNWTSVVTSCGNGNKYCCGDDHSCCDGDGGFLLNDSLVTIGGVATTTVTATGSTIPTEENSGSSDTSTKLAIGLGVGIPLTVLTGAMLSAGFLWGRRNAQKKTSENTPPGGADGMMMKSTIQPENYQDHPLVYPYEAPDSSLPPSELPSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PH50</accession>
    <name>A0A0G4PH50_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S015g000163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793148">
        <property type="protein sequence ID" value="CRL25577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PH50"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="36"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL25577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="124" mass="14265" checksum="C4ECC289DF6DE633" modified="2015-09-16" version="1">MRSNKCGEKYSEPGVSAPKYPPSYLLFIPWRKGPGILSLQESVLCKIYRHLPLVDKACLSLSCKRLYDLFGTILKERELESSPLLQFQLNILCVANYKVARTQLLIRLESRSWIYCGNCSVLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PHB8</accession>
    <name>A0A0G4PHB8_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S016g000018</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793149">
        <property type="protein sequence ID" value="CRL25737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PHB8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PHB8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01365">
        <property type="entry name" value="KISc_KIF1A_KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000050">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="7">
        <location>
            <begin position="106"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="567"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="509"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="576"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="213"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL25737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="675" mass="76128" checksum="5FAE8A58D418703A" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PHN7</accession>
    <name>A0A0G4PHN7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Multi antimicrobial extrusion protein MatE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S016g000143</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793149">
        <property type="protein sequence ID" value="CRL25862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PHN7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PHN7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL25862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="475" mass="51550" checksum="7F7AF64464CC41F8" modified="2015-09-16" version="1">MISEDQGATESSPLLRNIDPEAASNSKKSGWRQELAIISRYSAPLMISLLLQHALTGSSIFMVGHLGKREIGAVSLANMTAQITGYFVFQGLATCLDTLCPQAYGSGNLTLVGLHVQRLTLFMLVLTIPIGAIWWNADRIFLLILPSESQETALLAGLYLKIAIAGAPGYACFESGKRFFQAQGLFSASLVVLVICSTLNIFMGWLFVWRLQWGFVGAPIAVAVANSLLPVFLAFYVIFIKGSECWHPISVEVWRGWGPMLQLAIPSWLMIEAEVLAWEIMTLISSRLGATELAAQAAISTLSDFAFQISFSIAVAGGTHIAYLIGAGFLQRAATAARVMVIAAFGAGISNMLVILALRSVIPGLFSDIGEVWHYIFFLLPLGAVLQIPDAVATSLNSLLRAVGRPDLGSYVQLSIYYLVGLPLGIALAFGLHWSIFGLWCGILIGQSIIVSIEGFYFWKMVDWAKASREAVERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PHQ1</accession>
    <name>A0A0G4PHQ1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ceramide-binding protein SVF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Ceramide-binding protein svf1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Survival factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PCAMFM013_S016g000161</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Ceramide-binding protein that may transfer ceramides from the endoplasmic reticulum membrane to the cis-Golgi network membrane, and is thereby required for the biosynthesis of complex sphingolipids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Golgi apparatus</location>
            <location evidence="12">cis-Golgi network membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SVF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793149">
        <property type="protein sequence ID" value="CRL25880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PHQ1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PHQ1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.370.10:FF:000001">
        <property type="entry name" value="Survival factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.370.10">
        <property type="entry name" value="AttH-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023374">
        <property type="entry name" value="AttH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051385">
        <property type="entry name" value="Ceramide-binding_SVF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033394">
        <property type="entry name" value="Svf1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013931">
        <property type="entry name" value="Svf1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47107:SF1">
        <property type="entry name" value="CERAMIDE-BINDING PROTEIN SVF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47107">
        <property type="entry name" value="SVF1-LIKE PROTEIN YDR222W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08622">
        <property type="entry name" value="Svf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17187">
        <property type="entry name" value="Svf1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159245">
        <property type="entry name" value="AttH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Svf1-like N-terminal" evidence="17">
        <location>
            <begin position="54"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Svf1-like C-terminal" evidence="18">
        <location>
            <begin position="215"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00069547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00073016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00081132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF17187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CRL25880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="378" mass="41577" checksum="6061AF1BA4157E5C" modified="2015-09-16" version="1">MNWLKSTLSAVVGTEEPIYGPEAIQSVAKQAETTPFSDVNKEILRWRAHSYTNVETQTFYIMADNGTLVFVQVIYSNIVGIHTTAQFNVKVFDVSGKGDNKWFSDPLSNFMFDESMLSFGADNLSLTLNEEANSYTIKSTVNSGALVDIKFSQTAPGFVVGKDGTSYFGTDPKNPWGSMRHAFWPRCAVEGSITTKDQTYDLGGRGVFIMALQGMKPHHAAARWNFINFQTPTYSAVMMEYTTPPSYGSTTVNVGGIVKDGEVIYAGTANKVTHTETGQDEGSDWPAPKSIKWEWSGKTTDDKELTAEVNGALGSRLDRIDVMAEVPGFIKSIAGSVAGTRPYIFQYSPQEKLSFKLKLGDEEITEEGTMFSESTFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PI60</accession>
    <name>A0A0G4PI60_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">26S proteasome regulatory subunit RPN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S016g000169</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proteasome subunit S2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793149">
        <property type="protein sequence ID" value="CRL25888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PI60"/>
    <dbReference type="STRING" id="1429867.A0A0G4PI60"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000026">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016643">
        <property type="entry name" value="26S_Psome_Rpn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041433">
        <property type="entry name" value="RPN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040892">
        <property type="entry name" value="RPN1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18051">
        <property type="entry name" value="RPN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17781">
        <property type="entry name" value="RPN1_RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015965">
        <property type="entry name" value="26S_Psome_Rpn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 9" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RPN1 N-terminal" evidence="7">
        <location>
            <begin position="61"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit RPN1 C-terminal" evidence="8">
        <location>
            <begin position="846"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00057191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR015965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL25888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="903" mass="100217" checksum="D3AD5C25C006D2E4" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJ38</accession>
    <name>A0A0G4PJ38_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1688 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S018g000113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJ38"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJ38"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012469">
        <property type="entry name" value="DUF1688"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31687">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31687:SF3">
        <property type="entry name" value="PROTEIN URG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07958">
        <property type="entry name" value="DUF1688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL26420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="501" mass="55187" checksum="E98993812853BBA4" modified="2015-09-16" version="1">MGIFKRKDSKNSSQSETENDSFVTVNSARTSNTSLRSPGYKGSGPPASIPELPIARPPDPALDPAAYLRSIHAVRERSNIILNKAKKNQLNHFDVDMSKFEATASYVVSIIKRDYAPDYENIPPHGRWQHFDVGGRPRINQLLQSWPSRIDAQERTRRLIDLFVVSVLLDAGSGNKWSYRSKESGKVFSRSEGLAVASLEMFKSGLFSSDPTEPCQVDGAGLKKVTAEVLAKGMQHSEQNPLAGIEGRAGLLIRLSEALNNQDFFGVDARPGNMLDYLLGHPSTLASSVPIVPITTLWTVLMDGFSSIWPPSRTQIDRVSIGDAWKCSGLPKSPPAQQWESIVPFHKLTQWLCYSIMVPMSKLMLIHFAGSDLLTGLPEYRNGGLLIDLGLLTLKPEDMQRGIDAYKENAQIKGQPSVEVAPLFCAEDDVIVEWRAATVGFLDELLEEVNAQLGLKGSEDQLSLAQMLEAGTWKGGREIAEVSRPNTKEPPIMIRSDGTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJD1</accession>
    <name>A0A0G4PJD1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S018g000004</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJD1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJD1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000297">
        <property type="term" value="F:spermine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF38">
        <property type="entry name" value="POLYAMINE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="33"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL26311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="485" mass="53337" checksum="70C452F15BDDD5D8" modified="2015-09-16" version="1">MTHRQLESGTNDWRGPDDPDCPYNWPMWKRIYMTSIPAFLCINVSFASSIYTSGADNIAQHFDVSHTAALLGLSLFLWGLGLGAIIAAPVSEYYGRKIVYLSTVPIFGLFILGSGLAQNFATLIVCRCLAGFFGSAVVSVGGGTNADLWPPALAGFVYPFYFVSPFLGPALGPVIGGFVSEKKDFRWLEWVILFMVAFNYLYSIPQFETYKKTILQKRHRTEKQAEAPTNLKAAVPSSAVIQRIVLKPFKMLFVEMIVLFMTIYMAFNFAVFYSFFAAFPYIFGGQYGFTGSQEGLTFISIALGCVIGFLAVVYIDRKTYPELEAKYGVGTVPPEYRLYGAMVGCALNPVSLFWFGWTADRGVHWLSPVVAAVPFAVGNIMVYSSGALYIMNSYGSLHGASALSANSLLRYAAGGAFPLFTVQMFSSLGIGWASSLLGFVSVALVPVPWVLYKYGHRIRAHSQYITIQPIEPENPFVEDGVSACK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJR2</accession>
    <name>A0A0G4PJR2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Guanine nucleotide-binding protein, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S019g000015</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat WDR3/UTP12 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJR2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJR2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000157">
        <property type="entry name" value="WD repeat domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000178">
        <property type="entry name" value="WD repeat domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051570">
        <property type="entry name" value="TBC1_cilium_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN 3 WDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25173">
        <property type="entry name" value="Beta-prop_WDR3_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25172">
        <property type="entry name" value="Beta-prop_WDR3_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="110"/>
            <end position="143"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="term" value="P:chorismate metabolic process"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="CHORISMATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017318">
        <property type="entry name" value="Chor_mut_AroQ_eu"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chorismate mutase II"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0827">Tyrosine biosynthesis</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="14">
        <location>
            <begin position="146"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR017318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CRL27596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="266" mass="30358" checksum="1058FFE9CFE2BB71" modified="2015-09-16" version="1">MDTAIDLSDALKALDLANIRFQLIRLEDTITFHLIERVQFPLNKTVYAPGGVKIPNSEFSLLDYLLREQERIQSRVRRYQSPDEYPFFPDVLEEPILQPLEYPRILHENDVCVNDVIKERYISEVLPAVCPKFGREDRGETQENYGSAATCDVAVLQALSRRIHFGKFVAESKFQKDPETFVRLIKAEDRAGIDAAITNSAVELKVLERLGLKAKTYGTDPALPDENGPKINIDAVVAMYKECVIPLTKIVEVEYLMQRLKGTQWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPA8</accession>
    <name>A0A0G4PPA8_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RTA1 like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S026g000147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793159">
        <property type="protein sequence ID" value="CRL28282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PPA8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PPA8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021460">
        <property type="entry name" value="DUF3112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35184:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35184">
        <property type="entry name" value="YALI0C10208P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11309">
        <property type="entry name" value="DUF3112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL28282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="34958" checksum="05844315C52D8D5D" modified="2015-09-16" version="1">MAGPYMSKIASVGGRPTIPLDVPICAVFLALFIAGAACHMTLLRRNLARGHKFIPSGVTFGFCMSRIVANIMRIAWACHPTNARIAIAAQIFVAAGVLLLFILNLLYVQRMFRAVYPVVGWSRPLSLAFKALYALVVVTIIMVITCVVQSSYTLNPNTLRIDRDIQLYGQTYFAIISFLPLPLLLSILLSPNRKQIQQVGSGSAVAKVFIVGLVGSLLCLGASFRAGTSWMPPRPITDPAWYHSKACFYIFNFTIDISVVAIFFVGRVDQRFWVPNGSSKVRHYRRDENGSPLAAHDERDIESDGSTLSQELGEETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPD7</accession>
    <name>A0A0G4PPD7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S026g000109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793159">
        <property type="protein sequence ID" value="CRL28244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PPD7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PPD7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195844" evidence="1">
        <location>
            <begin position="27"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="46"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL28244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="456" mass="50816" checksum="429C11A12AE91C47" modified="2015-09-16" version="1">MRHTSFGLGGLLSFALLNSPFLHAQATPDVITRDVVIVGGGASGTYAGVRLKEMGKTFTLIERNSLLGGHGETFYTNDNKPINYGVEGYFNTSVTLDYLAKLQVPYELRVPAPAEDDYINLRTGKKVDAPEASKNQSIALHQWMDSISQFKFLEDGSYNFPDPVPEDLLLPLRDFIAKYKLDDAVWGVFSHGSGNILDMATLYVIQYIGVPHSKALLKGYIRPSHGIADVYTRATKVIGSDVIFNSQIESVDRSGDMVKVVARSSDGKTQHIHAKKLLVTIPPTTRHLTGFSLDNREASLFTKWHYQSYYAVLINETGIPDGHNLINIDPSNPFSVPYEPFIWRVDAQKVPGYHTIKLVGNEQFSEKDARELLESSIERLGQVGTFPATKPRIVKWGDHTPVTMSASAEDIRAGFYKNLYALQGHQNTFYTGASWCSDYSTLLWGFTEEVLKKMFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPZ4</accession>
    <name>A0A0G4PPZ4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Bromodomain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S027g000128</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793160">
        <property type="protein sequence ID" value="CRL28439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PPZ4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PPZ4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Bromodomain-like"/>
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    </dbReference>
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            <end position="168"/>
        </location>
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        </location>
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        </location>
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        <source>
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    </evidence>
    <sequence length="495" mass="54456" checksum="036CDCF7297A9B2E" modified="2015-09-16" version="1">MTSKRRAAATASPDMKFRRTKRQKVSGDDLMVPEESNRASSHLDSEPPEEADRTPESQAESEADFEGDSLQTAQDKIMSELTRLKDSDGEDVSYPFIGKPDRNLYRDYYEIIQHPVSLRSIQKRVRGTDSRKNSSKTTAYPTWQSFEEEVSYVWRNAREYNEDDSDISILAGVLEAHFHRRVAEAKKLVPNPLEVHRTLEMPRIKLKVGTTMPPMAQRLTLKMPGQSSDTLSKNDGHPSDVTFKNESQGNTQDIAGAGLPAGQEINRSPREFPLGGQFDSPRSSTRTTPSGSEQQQNSSMSAQGLLDSMSNAATLAISTSQNPLNASFDVSSGIPRHSSSGSAHYQPHFGSPMDSLLRRSGQDPKMALISNVRILTHASSSLQPDFCLDIPPSSLVSQQNITVHLPPSHSILTVRPRLAASTSQRQIKIVALTGIQRLHSSGDAATISYDIHLHPGMTKVDLEAIAGPARGVPKSSPPGSDVDYERVTLFFNLLR</sequence>
</entry>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="CRL28524.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="38" mass="4277" checksum="26147EB166057F2E" modified="2015-09-16" version="1">MSSLGRIVEAWTDLISTFAIVFPTPPHSTHRLYTRGSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
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                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <feature type="domain" description="HMG box" evidence="6">
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            <end position="218"/>
        </location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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        </location>
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        </location>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
    </feature>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL28720.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="708" mass="78130" checksum="25F3651ECB8E1D35" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQP6</accession>
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        <submittedName>
            <fullName evidence="8">Velvet factor</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
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        </lineage>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CRL28714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF18">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <location>
            <begin position="14"/>
            <end position="184"/>
        </location>
    </feature>
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        <location>
            <begin position="18"/>
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        </location>
    </feature>
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            <end position="228"/>
        </location>
    </feature>
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        <location>
            <begin position="317"/>
            <end position="348"/>
        </location>
    </feature>
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        <location>
            <begin position="372"/>
            <end position="448"/>
        </location>
    </feature>
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        </location>
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        </location>
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            <end position="422"/>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="448" mass="49203" checksum="823F5E846117E35F" modified="2015-09-16" version="1">MSATFSDASLSREAQGSDFDLIIRQQPNRARVAGGKEKERKPIDPPPIVQLRVREEGTYLAQHYLQSPYYFMCCSLYDATEERPVPVAPSTALAGTLVSSLHRLKDVDNSDGGFFVFGDLSVKIEGEFRLKFTLFEMRKDRVSYLKTVISERFTVSPPKSFPGMMESTHLSRSFADQGVKLRIRKEPRTMLKRTTRPDEFHQPVPTRSPERQAVQIPPSSSYGGYPPAARDYGYYGQQPPVKRHRTSIDYGRQQGIYDVDGRMARQMDPYSQPTAAMYAGQPATYQTPAAMQTYSTGQVVPDYAAMYPGMQASAGMQASTGMQGSAPMSQIPDPTGQSRSSQQQQAAVGQLMAMNQPGTPTPDSTGAMIAQGYARSGYPPSSAILPPLQRNRDYPQGTNGSARGYFDQTPQANTPILPSQMVNEGDRFGSVAGPATFDHPDSSNGTPQ</sequence>
</entry>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="525"/>
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    </feature>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL28744.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="858" mass="94937" checksum="79E50927A1C3F42A" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRT5</accession>
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        <submittedName>
            <fullName evidence="2">Zinc finger, C2H2-like</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PCAMFM013_S033g000065</name>
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            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793166">
        <property type="protein sequence ID" value="CRL29145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PRT5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Fun_TF"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
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        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL29145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="502" mass="56468" checksum="785C3375F8237A6C" modified="2015-09-16" version="1">MISGCVTETVHPFQLLRYLPVHRVLICLHCRYAIQPGAIVRHLKEIHHLKRLRRRAFVEYASQFELADVDSIILPDETQFPVDSLPIHDGLACRFEGCGHLCATIQRMKAHWSSVHHLSPRNDGNWCSVPLQTFFRGNALRYFTNPALLASSTDSLEEPMSATEKPPITTITTPDLDEAQGLSSLVAYENNISLSVENMHLFDHYLNHTYKTISCGPETDGIFRIIVPQLAAKFPFLLHGMLACSALHLASSNPLNKKSYMLQAIQNQDQALPAFHLATMHVDRNNCQAILSYAFFLVVYGLSSESEDETLFLGNQRTNSSSNWISLLRNGCSMLCDVWSELKHGPLAPFAALWRDDIGVTADPNDPLLVSLLSAISESSETVATVQRFSGEDVHIYRDAALKLAGAFEFTRRFGASLSVWDALNSWLTQVLPEYFDLLDQNHPGALLLLAHYAILLKPLQAEWFLNGRVTKLMDEIGRRLEGNCSLHIWKLFLIARREFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PS02</accession>
    <name>A0A0G4PS02_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Actin cytoskeleton-regulatory complex protein SLA1</fullName>
        </recommendedName>
        <alternativeName>
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        </alternativeName>
        <alternativeName>
            <fullName evidence="17 18">Osmosensor SHO1</fullName>
        </alternativeName>
    </protein>
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        <name evidence="22" type="ORF">PCAMFM013_S031g000024</name>
    </gene>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SLA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793164">
        <property type="protein sequence ID" value="CRL28856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PS02"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
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    <sequence length="264" mass="29266" checksum="6311A30F1510C806" modified="2015-09-16" version="1">MATEYPVSYLSWNDSGPASIVLIHGAFVTGSWWDLVVPHLSTKYHVLAPDLPAHGQSTQEEFSVQSAADLLAQLIRDKAIDSHAHVIGHSLGARVAIQLACTYPDLVQSVFVSGFLSIPRTVFTPYIPRAVWAMQHVENLIPRSVIRWAMDGTDIPHNTSTTTLKLIRQIATPSPELQWPEPWAARTLIVVAAKGGLVPSGDSKEVGLRLMKTGREGNPETIAYFHPEMRHPWNRQNPKLFADTAMAWIEGEDIPDGFEKLVHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PTG9</accession>
    <name>A0A0G4PTG9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class II aldolase/adducin, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S036g000022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793169">
        <property type="protein sequence ID" value="CRL29438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PTG9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PTG9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF25">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 14 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="1">
        <location>
            <begin position="41"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL29438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="280" mass="30506" checksum="DDC0669493DF9C3E" modified="2015-09-16" version="1">MTPSIDDGAKLTGLAALSQGTPLPGVPKFKNFETQREYMLNHMAGAFRVFARHGFVEGMAGHISMRDPENPDLFWTNPLGIHFGLINPSDMILVNEDGVAVGGNMSRPANAAGFLIHSAIHRARPDVNAACHFHSTYGKAWSTFAQPLEMLNQDVAIFYGAQSVYKEFGGVVLKEEESTALAESLGQGKAMILRNHGLLTVGETVDEAAYLFLLMEKSCMIQLAADAAAASGREKLYIDDEAARFTYENTSDPESLFAEFQGYLQWESAVSHDGYKAMGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUJ6</accession>
    <name>A0A0G4PUJ6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S045g000051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793178">
        <property type="protein sequence ID" value="CRL30185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PUJ6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PUJ6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="750" mass="85932" checksum="47A331FB122CA3F2" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUT3</accession>
    <name>A0A0G4PUT3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S047g000013</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793180">
        <property type="protein sequence ID" value="CRL30285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PUT3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL30285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="69" mass="7336" checksum="84FE4E005503A226" modified="2015-09-16" version="1">MSKHSGRSSPAFLKGGQNMKTSLIQFANGASPREPYGTLTVILLHEDNANVSLVNHDANILLATGDSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVQ5</accession>
    <name>A0A0G4PVQ5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S055g000001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793188">
        <property type="protein sequence ID" value="CRL30586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PVQ5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PVQ5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF5">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="5"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="281"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL30586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="352" mass="38817" checksum="01A16DE252FE3FFA" modified="2015-09-16" version="1">MTQPQKTIAVVNATGRQAASLIRVASAVGYSVRAQIHSLKGVIAPELQQLPNVTLLQGPLLGNIALMDELFKGAQLAFINTTSQSGDEVAIGRDLADAAKRSGSIQHYIYSSMPDHSVHGPWPAVPQWAPKFTVENYIRQLAMPATFVYAGIYNNNFTSLPYPLFQMELLEDGSFEWRAPFDPEIPLPWLDAEHDVGPTLLQIFKDGTKKWNGHRIALTFETLSPLQVCAAFSRALDRPCQYVRVPKIEIKVNIPPGYREQLEALEELFGRCDAPYFPQPEFSQPAAGSPKGLGPAGGKGAGAGMMQGPGGVISLRVTDESRHLWQGWRDMEEYAREVFPVEEEANGLDWMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PW18</accession>
    <name>A0A0G4PW18_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S057g000018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793190">
        <property type="protein sequence ID" value="CRL30696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PW18"/>
    <dbReference type="STRING" id="1429867.A0A0G4PW18"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL30696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="75" mass="8364" checksum="2727BED2D6594358" modified="2015-09-16" version="1">MTPNFPSFFLYGPPASLTVALFSGHLRIAIVKLAGGITLNQFEVPLIYKTTTKQPASNHCQYVRLVCSQWQWAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PWV3</accession>
    <name>A0A0G4PWV3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S065g000012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793198">
        <property type="protein sequence ID" value="CRL30962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PWV3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PWV3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL30962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="204" mass="22002" checksum="F18E8C7739544957" modified="2015-09-16" version="1">MELDIYLDVSRATAGMAHLTLDSTREYLILTRRPDPEGYSPSTDSHRALASLTSETILLTESGGVKFGSHMLALASAGVERTCGIHAADLVTLKLFALSEIVKALRKQMSPLGLWSAEVQNLPDRSMAVSLDDLLQDHIVSQMQGGELKMLVSVVSKTSHYDIKYTQACGNAGGSDWPDTYGLRVVSSALFVSSGPLSPDRLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PX29</accession>
    <name>A0A0G4PX29_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S070g000001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793203">
        <property type="protein sequence ID" value="CRL31052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PX29"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL31052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="110" mass="12537" checksum="9112B54FCBD2F88E" modified="2015-09-16" version="1">MSYRNNYELYSRGSIDSRCSPPPDKLLTPLALLYPHVTALQPEYDPINCTFTGYHRTGYWAAAYTTQANDEPFMSTHRGSDGPSCRFVSKLRRLLSRDNLKSRRGSRTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PX81</accession>
    <name>A0A0G4PX81_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">molybdopterin adenylyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.75</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S075g000006</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>adenylyl-molybdopterin + molybdate = Mo-molybdopterin + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>molybdopterin + ATP + H(+) = adenylyl-molybdopterin + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:31331"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58698"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MoeA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the MoeA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the MoaB/Mog family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.75" evidence="4"/>
    <dbReference type="EMBL" id="HG793207">
        <property type="protein sequence ID" value="CRL31102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PX81"/>
    <dbReference type="STRING" id="1429867.A0A0G4PX81"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061598">
        <property type="term" value="F:molybdopterin adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="entry name" value="MoeA, C-terminal, domain IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.10">
        <property type="entry name" value="Molybdopterin biosynthesis moea protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.190.11">
        <property type="entry name" value="Molybdopterin biosynthesis moea protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192:SF5">
        <property type="entry name" value="GEPHYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="MOLYBDOPTERIN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="MoeA C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="MoeA N-terminal region -like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="5 6" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="7">
        <location>
            <begin position="7"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="MoaB/Mog" evidence="7">
        <location>
            <begin position="417"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL31102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="692" mass="73948" checksum="A2B7F0A0D4B98498" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PXH2</accession>
    <name>A0A0G4PXH2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S061g000035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793194">
        <property type="protein sequence ID" value="CRL30861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PXH2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL30861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="65" mass="7348" checksum="82BA102C4569EE5A" modified="2015-09-16" version="1">MVGKHIYNCQPSDVPIPSNEVYLKGFSDSEPLMETSLKNPLAIEQFQPILETLVDLDRDDPKLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PXM8</accession>
    <name>A0A0G4PXM8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SET domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S102g000002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793233">
        <property type="protein sequence ID" value="CRL31275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PXM8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PXM8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="H3K9_HMTase_SUVAR3-9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45660">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETMAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45660:SF29">
        <property type="entry name" value="SET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G09180)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="160"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL31275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="301" mass="34635" checksum="0006BF1BB84944BE" modified="2015-09-16" version="1">MTYYLYPIHTRTTYSLIKEADDRAWGCLLQKIHENFLSIELYSHNRTLKWRDILWIYQNYPIPGLPDMKLEIETYMNWKVDHPHHTVITLDGKLKEPSYNGQLQKHINESIYDPKKWSGQKQDPTLRHKANGTPTNVGRQCVRCGSPVSCACRLETRAGELIELREYSGTGTGVRALTRFRRGDILDIFMGELLPDIVENVYPLTQNDDKNNTTTTTTTTVNSLCTICPHQFGNWTRFISHSCRPATQFMTRTIGNRVVCTVEVIRDILPFEEITVGYGDRYWTALDYDCLCGHCDGSGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PXX5</accession>
    <name>A0A0G4PXX5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Taurine catabolism dioxygenase TauD/TfdA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S098g000001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793229">
        <property type="protein sequence ID" value="CRL31258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PXX5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PXX5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL31258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="296" mass="33810" checksum="8C409BE662D87B30" modified="2015-09-16" version="1">MQRLSRPLHTASKLFRHKTRSISSIHSIPYIPVHGPTLAYESSHLGTVNRTLQKEGILHMQLAFPDDESSYIQDLLLNLHKNHAHGLPLTHSANRGWMWDIRPSPGSFQSNNHQARSETTEEFPWHTDCSYEAEPPRFFALQVLQPDLCGGGTLSVLNVDQLLTLLSPFAREWLFTPNYRITVPPEFIKLQGETEIVGNLLTINPNSNTTQLRFREDIITPLCEEAAKALAELKSVLLGPAAKEQILNLLPEMLPRGSIILMDNGRWLHARNEVKDPNRHLRRVRWDARPFTQPYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PY05</accession>
    <name>A0A0G4PY05_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Bax inhibitor-1-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S068g000015</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793201">
        <property type="protein sequence ID" value="CRL31029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PY05"/>
    <dbReference type="STRING" id="1429867.A0A0G4PY05"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd10429">
        <property type="entry name" value="GAAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF50">
        <property type="entry name" value="PROTEIN LIFEGUARD 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL31029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="273" mass="30760" checksum="D31E3F6CE88C8BC7" modified="2015-09-16" version="1">MAANTRYEPAPQRDSLDDPSYSQAPPSYQATAVPAEPAPRSEDDNLPDDFKFGGTVAEGTIDIRMQFVRKVYSILTAQLLLTTILSSISFFNDSYRVWIQSNFWLMIISVFGALGFMLATFWKRKSYPANLLFLSGFTILEAYSISVATSFYDARVVVQALALTLGIFVALTLFACQTKYDFTDWMPYLFGALWFMILFGFVAMFIPFNSTIEIIYGVLGALIFSGYILVDTQLVMRHYHVEEEIAASISLYLDVLNLFMSILRILNGANNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PYV8</accession>
    <name>A0A0G4PYV8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S130g000003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793261">
        <property type="protein sequence ID" value="CRL31354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PYV8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL31354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="94" mass="10243" checksum="B2ED2DEF33CF50ED" modified="2015-09-16" version="1">MIETPSHAEKVRTSLTLTAYIPRSADQTIPLKPGNRRINEVNDILVADVNRGTTALGGDTKRTGAVLNQLILDAETYHRLGTTTSDVCSDFFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NTC9</accession>
    <name>A0A0G4NTC9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S001g000189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NTC9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL17229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="409" mass="43633" checksum="E7A217AABC8D8B71" modified="2015-09-16" version="1">MAARTLDRMRKAQSLIRECHDWFVEKNEMLLAVEMCQIEGSLALLFERSCFQNSPCPGLQEENLPRLPPYNGHRRRNGRGSYNGYRRVHPANRGGTEASTGRAGSGQNVPAQTPASTSKDIVSKSNCPGAVPKGPRAQSAVRGVSPPTGVLLDFNDDVEFVQLPPSVLANMETAQTVDLGSKEKERSSGCFAAYSSDQPAPGVEVRLDGDDKSVDQTIAHTAHAAPADPDTPVSSYCPPSAVEGVIPASSPLYLPGSPACDPSQDGLPQTSQKSQPVNETNKSKKCDSKNCEESPVLTNTGGVTEGMLVNLDDDLAVILPAGTDVSADIVIHPEENDVLAAGLDSGVGDNHQPEDLEDDEIVFQGNVAKTLGSGFKALFVSSDDDSKPARCPIDLKAIFEEYSEVVIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NTE2</accession>
    <name>A0A0G4NTE2_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Lysophospholipase</fullName>
            <ecNumber evidence="3 10">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S001g000330</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the release of fatty acids from lysophospholipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the lysophospholipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="3 10"/>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NTE2"/>
    <dbReference type="STRING" id="1429867.A0A0G4NTE2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07203">
        <property type="entry name" value="cPLA2_Fungal_PLB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000010">
        <property type="entry name" value="Lysophospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF62">
        <property type="entry name" value="LYSOPHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6 9 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005118191" description="Lysophospholipase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="PLA2c" evidence="11">
        <location>
            <begin position="50"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL17370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="639" mass="68500" checksum="183460B2508D524F" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NTF7</accession>
    <name>A0A0G4NTF7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Six-hairpin glycosidase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S001g000355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NTF7"/>
    <dbReference type="STRING" id="1429867.A0A0G4NTF7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052043">
        <property type="entry name" value="PolySaccharide_Degr_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886:SF8">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL17395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="367" mass="41822" checksum="7CF48F0FE8206CB7" modified="2015-09-16" version="1">MSSPKPTGPEIHSAVNLLIDNLVNIKDETGRFLLPLPDGRIIDTKSWQGWEWTHGIGLYGVWKYYELTGDERLLKIIEDWFAARFAEGGTTKNINTMAVFLTLAYVYEKTGNVIYLPWLDAWAEWAMHELPRTRYGGMQHMTYITENYQQLWDDTLMMTVMPLAKIGKLLNRPQYIEEAKKQFLTHIKYLFDTKTGLWFHGWTFEDGGHNFADARWARGNSWVTIVIPEIIELLDLQPNDPIRLHLIDTLEAQCEALQRLQSSSGAWHTLLDHPDSYLEASATAGFAYGILKAVRKRYIGAQYRPVAEKAISAVIGYVDKKGELQNTSFGTGMGDCLDFYKEIPLTSMPYGQAMAIMALGEALRDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NTH0</accession>
    <name>A0A0G4NTH0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S001g000362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NTH0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL17402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="518" mass="58894" checksum="5AB3CB5176F2C4DB" modified="2015-09-16" version="1"> </sequence>
</entry>
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    <accession>A0A0G4NTI6</accession>
    <name>A0A0G4NTI6_PENC3</name>
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        <submittedName>
            <fullName evidence="7">Actin/actin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S001g000390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the actin family.</text>
    </comment>
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    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Chromatin remodeling complex subunit (Arp5)"/>
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    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000025">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="14"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="442"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL17430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="754" mass="86623" checksum="3218CEED76FD983D" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NTI7</accession>
    <name>A0A0G4NTI7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arf GTPase activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S001g000259</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NTI7"/>
    <dbReference type="STRING" id="1429867.A0A0G4NTI7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08204">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000026">
        <property type="entry name" value="GTPase activating protein for Arf, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF7">
        <property type="entry name" value="ACTIVATING PROTEIN FOR ARF, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G09120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="3">
        <location>
            <begin position="15"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="275"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="397"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="281"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="333"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="397"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="446"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="526"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="543"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="578"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="589"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="611"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="634"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="700"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="711"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="758"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL17299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="794" mass="85699" checksum="430F907EC475FE17" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NTN4</accession>
    <name>A0A0G4NTN4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase superfamily, zinc-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S001g000412</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NTN4"/>
    <dbReference type="STRING" id="1429867.A0A0G4NTN4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF5">
        <property type="entry name" value="OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01420)-RELATED"/>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWY8</accession>
    <name>A0A0G4NWY8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S002g000488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWY8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL18618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="264" mass="29327" checksum="45A176F22678F32A" modified="2015-09-16" version="1">MPSAVGEQMISGGDPDRPSIANTNFCLPFVSLAPHLSLQINQCTDWNKGSVWPIFNIWRPGFFGTSLTQLGPNPVKLRNKADFVVTAYQNDLEILKTKNTNAILFSTEGLVAGVDVDAPPWYGCKVCNSHRGYVLLPNGERWHWVEIDGECYKFNRQDDQRDQDVPLKTLIWEFQNSWTPSKDLPADLPFAVNRDARVCRVSESSPLAGPGIAGSPVAVMNRDGFIFFDGVGPKMAEIQTEDNRALILISGLAIAKYEGWLAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXQ9</accession>
    <name>A0A0G4NXQ9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dihydrofolate synthetase</fullName>
            <ecNumber evidence="9">6.3.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S002g000715</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>7,8-dihydropteroate + L-glutamate + ATP = 7,8-dihydrofolate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.12" evidence="9"/>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NXQ9"/>
    <dbReference type="STRING" id="1429867.A0A0G4NXQ9"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008841">
        <property type="term" value="F:dihydrofolate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.10:FF:000010">
        <property type="entry name" value="Dihydrofolate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.20:FF:000010">
        <property type="entry name" value="Dihydrofolate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF0">
        <property type="entry name" value="DIHYDROFOLATE SYNTHETASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001563">
        <property type="entry name" value="Folylpolyglu_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 9" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL18845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="413" mass="44591" checksum="4D4B417DC30E51B4" modified="2015-09-16" version="1">MIELGLSRVASLLQQTPLSWKSIHIAGTNGKGSISAYLSHLLSTGGVRCGRFTSPHLIDRWDCITIGEKVVQESLFRQIEDQVKLRDQTLGIGASEFELLTATAFEIFNHEQVEVGVVEVGMGGRLDATNILNNVLVSVITKIGVDHQAFLGSTLGEIAREKAGILKPGVPCVVDNTNSQEVVETVRAHIQELGIDSLFVSPATASEQIPALAPYFQKLDLEPHQQENMCCAVSALRLALSQLRPEMDAFSLLPYLADVTWPGRLQNIVLQPLVARAEPILLDGAHNAQSAEVLGKYVDRKMRIQGQPVTWVVAASSGKDLAGVFGSIIRPGDRVATAEFGPVDGMPWVQPTNAKELASSIQAIQNIGQVQSFEGDLLPALQWASEQSQGGPLVIAGSLYLVSDVLRLLRAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXW6</accession>
    <name>A0A0G4NXW6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glutamine amidotransferase type 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S002g000802</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NXW6"/>
    <dbReference type="STRING" id="1429867.A0A0G4NXW6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF6">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL18932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="309" mass="34493" checksum="B87D24731771041F" modified="2015-09-16" version="1">MVHHIHIAVLDVDIPARKLYEARGLCSAHFRTILRETASRLNETLFSEKEQLEVKITPYDIRGGHYPDLYKLRGHAGEDQIPVQSPVDAVLITGGSPGVYEMDHSPWMQELEKFVKTVYNQYPEVRILGTCFGHQLISHALVRNVEDPVRDVWVEQCPLGREVGIYTVQLENAFVKSFPGALGDLPEGRLRIQMFHGDRVMAVEKGIAVTLTDSPPVSLPAPWINIGSTPICPIQGLYHPGRVLSVQGHYEMDAFGLTKMCLESAPVMGWKESKLALFLEQVGDDRQVCQDDSKAFASVVVSFLAGFEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYA7</accession>
    <name>A0A0G4NYA7_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">25S rRNA (uridine-N(3))-methyltransferase BMT5-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S002g000947</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070042">
        <property type="term" value="F:rRNA (uridine-N3-)-methyltransferase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019446">
        <property type="entry name" value="BMT5-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF26">
        <property type="entry name" value="FERREDOXIN-FOLD ANTICODON-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10354">
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL19077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="399" mass="44224" checksum="7257C0B27D120DFD" modified="2015-09-16" version="1">MPRNNKKAKSAPPPRPRGPGKPSGPSSNPAKGQQHGNGQKQGSGNANAPKKASMQANQRPIVPFLRKDRILLIGEGDFSFARSLAKQYKCRNLCATCYDSKEALYNKYPQAPQNISDILNASSKPKVESTEPEEQPEESKSEEQDSTNPNQQTPKVIFSVDARKLGTPAGGGKEIRTGFTRRERKRPAWYQQDEPAGPPYHPGGPWDVICFNFPHVGGLSTDVNRQVRANQELLVAFFKACVPLVSKPPPLMDADDDEWVYADGEESEDDDEDEDDEGGEGEELGKDDDTTGKGFRVGPGQILVTLFEGEPYTLWNIRDLARHAGLVVVTSFRFPWTSYEGYSHARTAGHIEGKDGERGGWRGEDREARMYVFEVKQKEPTKKGGKKRSRDDDDSSDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYC4</accession>
    <name>A0A0G4NYC4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S002g000967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL19097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4NYC4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005194881" evidence="1">
        <location>
            <begin position="18"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL19097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="208" mass="20581" checksum="53C0A11FF1F7ABFD" modified="2015-09-16" version="1">MRYNLFTPVLLATTALAVPVPNQNDVIGDAGVALNVGGDKTVGVLDHKRDVIGDLGLAANVGGDKTVGVLDLKRDVIGDLGVAANVGGDKTVGVLDHKRDVIGDLGVAANVGGDKTVGVLDLKRDVIGDLGAAANIGGDKTVGVLDLKRDVIGDLGVAANVGGDKTVGVLDLKRDVGHGGDDDSGSDVIGKLGAAVNVGGADTIGVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYS9</accession>
    <name>A0A0G4NYS9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S003g000028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NYS9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075306">
        <property type="term" value="P:regulation of conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043935">
        <property type="term" value="P:sexual sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052979">
        <property type="entry name" value="Adenylate-forming_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN TMPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL19237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="568" mass="63518" checksum="135DB48BCCA66F86" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZY3</accession>
    <name>A0A0G4NZY3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S003g000427</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZY3"/>
    <dbReference type="STRING" id="1429867.A0A0G4NZY3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL19636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="215" mass="24625" checksum="7696183A51E07BA0" modified="2015-09-16" version="1">MPLIATSVLIVLVYITTRIIYRLYFHPLSKFPGPTLAAISYLPEIYYDVLKGGTIVRINPREIHIKDPSFYDEIYTSGKRVRHKDPAFTVALLTPGAIASTNSHKQHRLRRALLNNFFSKRSVMDLEETIQAKVNILQNRFMGAFREKLVLNIPSVFAALTADVITHYSHGKSLGYLDVPDFKNNMMEALDSLFRIFHINRFLPMLAVMLSRPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P084</accession>
    <name>A0A0G4P084_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase S33, tripeptidyl-peptidase C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S003g000494</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P084"/>
    <dbReference type="STRING" id="1429867.A0A0G4P084"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="4">
        <location>
            <begin position="521"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL19703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="624" mass="69764" checksum="740CFB8107C35600" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0D4</accession>
    <name>A0A0G4P0D4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aromatic prenyltransferase, DMATS type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S003g000568</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tryptophan dimethylallyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P0D4"/>
    <dbReference type="STRING" id="1429867.A0A0G4P0D4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13929">
        <property type="entry name" value="PT-DMATS_CymD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033964">
        <property type="entry name" value="ABBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012148">
        <property type="entry name" value="ABBA_DMATS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017795">
        <property type="entry name" value="ABBA_NscD-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03429">
        <property type="entry name" value="arom_pren_DMATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40627">
        <property type="entry name" value="INDOLE PRENYLTRANSFERASE TDIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40627:SF3">
        <property type="entry name" value="PRENYLTRANSFERASE ASQH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11991">
        <property type="entry name" value="Trp_DMAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000509">
        <property type="entry name" value="Trp_DMAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00036">
        <property type="entry name" value="Aromatic_Prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01162">
        <property type="entry name" value="I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="83"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000509-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL19777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="470" mass="53590" checksum="0F97BA4CB7B4FBF2" modified="2015-09-16" version="1">MGSVESPNCSGSFVYKTITEFADFPNHDQKLWWHSTAPMFAEMLEVAEYDIHSRYKALGFYQKFILPFLGVYPTKINDRWLSILTRYGTPFELSLNCTHSVVRYTFEPITATTGSLKDPFNTHAIWDALDTLLPLQKGIDLVFFTHLKRDLTVNDQDAAYLLENQKVDGQIRTQNKLALDLKGGDFELKVYIYPALKSLATGKSIQDLMFNSVHRLCHQYPTLSAPLHTLEEYVHARGTSSTASPRLISCDLCDPRKSRIKIYLLEMNVSLEAMENLWTMGGRRSDAPTLAGLEMIRELWGLINLPSGMISYPEPYLKLGEVPNEQLPLMANYTLHHNDPMPEPQVYFTTFGMNDGRVADILATFFKRHGYDHMLHTYKDSLRAYYPHVDHDNVNYLHAYISFSFRNGSPYLSVYLQSFETGDWPISSSFSSNSASFGAPAFKPVSRDICRGHPTSFEVPLTKYQVMTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0J4</accession>
    <name>A0A0G4P0J4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S003g000634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P0J4"/>
    <dbReference type="STRING" id="1429867.A0A0G4P0J4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17242">
        <property type="entry name" value="DUF5315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL19842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="275" mass="29702" checksum="10844713F8208AA0" modified="2015-09-16" version="1">MSVVLSNNLLKMDLSRKPTNPNPQRLPPPALFQGPPSHNASNISLPVPPAASTLATASGGQPPPLHRNRSPRGAEGDNAEKSSLLSPFVSRRPSKNDVDGSDAIWQEMQSALSEVELSAVTSENVFGAKHSEALEDLRMKQLKLAQAWARSEADDEVVDPGHSGADVASGKTSSAQRGVEESKPQHDAATETSASRGSLSHRTLDDETEKDIHLARKRREANDRYFDRVNQGVLDVVAKLEEVAQAMRTVERESKDIWSDSESVTTTAPSSTHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0J5</accession>
    <name>A0A0G4P0J5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="9">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCAMFM013_S003g000617</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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    <sequence length="99" mass="11283" checksum="70B43FFCC2E80F6F" modified="2015-09-16" version="1">MGNGKGKNKGKGRGKKRSRGPKETKIATKVATTVKNKGTFLGDHHCHGRHAPTWRCLRLGHVVQCPTHRKSFPRRLEDCVQCISAERRLVQQERKEKMK</sequence>
</entry>
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    <accession>A0A0G4P317</accession>
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            <taxon>Eurotiomycetidae</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <source>
            <dbReference type="EMBL" id="CRL20720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="55" mass="6640" checksum="97491C403DD251E3" modified="2015-09-16" version="1">MYEKRDVMAANPYWCYAHQHQLDRELASRHRELKDLKAQAKRDAAKERGIWKQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3D7</accession>
    <name>A0A0G4P3D7_PENC3</name>
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        <submittedName>
            <fullName evidence="5">Cyclin-like F-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S004g000750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
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        <location>
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            <end position="114"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="231"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL20808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="305" mass="33621" checksum="EE61B1C34FD7CAE9" modified="2015-09-16" version="1">MGLSNLPTELVQAIAELLSEKDVLVFAQLNRQFFDILIDYLYARNATRSNASALIWAADKGYESTARQALANGAKPSATNRRGDTSLHLATNAGNLRMARFLLNAGVDVNKQNKYSEIPLSAPARDGNEELTPLSYAAMNGHVDVLKIFLATNRVDIESKDSRGWTPLAYAAAYGQAEVMEVLINVPGIQLESRAQWGITQLMLAVIHGHEAVSRILIEQESVKGDATCDAESTALWFAVVQGHSNIVKLLLDKGCNPHLTCHKGNTPLWLAIDHGQEEIVKWMQQSEHQPNVSLNPTERRKQMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3J1</accession>
    <name>A0A0G4P3J1_PENC3</name>
    <protein>
        <submittedName>
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    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S005g000038</name>
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    <organism evidence="11 12">
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
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    </comment>
    <dbReference type="EMBL" id="HG793138">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4P3J1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00067">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
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        <location>
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            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195368" evidence="10">
        <location>
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            <end position="530"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
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        </ligandPart>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL20874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="530" mass="59342" checksum="73FF803BE26F07B1" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3W6</accession>
    <name>A0A0G4P3W6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATPase, AAA+ type, core</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S005g000179</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P3W6"/>
    <dbReference type="STRING" id="1429867.A0A0G4P3W6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19509">
        <property type="entry name" value="RecA-like_VPS4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000022">
        <property type="entry name" value="Fidgetin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000093">
        <property type="entry name" value="Fidgetin-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF17">
        <property type="entry name" value="FIDGETIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="573"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="93"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="151"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="277"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="335"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="414"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="496"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL21015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="829" mass="90564" checksum="EEAC60ECF1B5D5DB" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P4X1</accession>
    <name>A0A0G4P4X1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP-binding protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S005g000517</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P4X1"/>
    <dbReference type="STRING" id="1429867.A0A0G4P4X1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01876">
        <property type="entry name" value="YihA_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001874">
        <property type="entry name" value="GTP binding protein (EngB), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00321">
        <property type="entry name" value="GTPase_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052279">
        <property type="entry name" value="EngB_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030393">
        <property type="entry name" value="G_ENGB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019987">
        <property type="entry name" value="GTP-bd_ribosome_bio_YsxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03598">
        <property type="entry name" value="GTPase_YsxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46498">
        <property type="entry name" value="GTP-BINDING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46498:SF1">
        <property type="entry name" value="GTP-BINDING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51706">
        <property type="entry name" value="G_ENGB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EngB-type G" evidence="8">
        <location>
            <begin position="89"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL21353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="313" mass="34154" checksum="A955A2FE8DF952E4" modified="2015-09-16" version="1">MMNSISKCRNPASRISLYTTIRALSSSSNPNSKRELKDLTPSDLCYYWDTRPPKDEQLAFADKVFTPSRHSPLKLWSAAKFRTTPFASVEPEVAFLGRSNVGKSSLLNAIMGQEICWTSSKPGRTREMNAFGIGGTKGGESKVVLLDMPGYGKASRSEWGAEIMKYLQGRKQLRRAFLLIDSTHGIKQTDAEILRLFRHHAIPHQIILSKVDKFLVRQLKQIKTGVTPANIERLQLLLQGIKPIVQPDPRASEGPGSLGEILTCSAEAKIGPGRSLGIDAVRWSILSAAGIDGSLQGGRLAVPTAAETSATLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P4X2</accession>
    <name>A0A0G4P4X2_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable E3 ubiquitin ligase complex SCF subunit sconB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Sulfur controller B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Sulfur metabolite repression control protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S005g000518</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the SCF(sconB) E3 ubiquitin ligase complex involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SCF(sconB) E3 ubiquitin ligase complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P4X2"/>
    <dbReference type="STRING" id="1429867.A0A0G4P4X2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF1">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
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    <sequence length="1080" mass="118179" checksum="A16E9266CE11A6B7" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5C3</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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</entry>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
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                <person name="Lacoste S."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="58" mass="6691" checksum="78DD72CB740C452E" modified="2015-09-16" version="1">MHFIRDILVFSAYSRARLSKDLKGIPTGKRLPVKCRRLKVFTDLARVYHGPSQSALLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-11-27" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6B0</accession>
    <name>A0A0G4P6B0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Urease accessory protein UreF</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
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                <person name="Abraham A.L."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00046339"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL21851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="306" mass="33116" checksum="D2A48FBF8CCEBC46" modified="2015-09-16" version="1">MIPKDTQELEAEVTLLESQLQDARAQLAASEYPSPPSSWAVKEQYNTNNNKLTTSTRTSLHALLLLSDSALPLGSFAYSSGLESYLAHNKPSRTAPITSFHRFLKLSIASIASTSLPYVLAGHRHPSTLDTLDNDLDASTPCIVAQRASIAQGRALIGVWERAFRVSFAGPENPASGETAAAVAAIDDLSDALKSCLEEDEDLGPKGHFAPLWGVVCRAMGLDLQQTAYVFVMNHAKAVLSAAVRAGVMGPYQAQNVLASQALQDTMMKRIAREWNTPVEQAGQVVPALDLWVGRHELLYSRIFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6F3</accession>
    <name>A0A0G4P6F3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S006g000435</name>
    </gene>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P6F3"/>
    <dbReference type="STRING" id="1429867.A0A0G4P6F3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF181">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="61"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL21895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="430" mass="47459" checksum="30BF4788D803B3B8" modified="2015-09-16" version="1">MDSDKLEESLQTIHHEQVLDQASNCTEKPVYRDPHGLPLNPQPTSFKDDPLNWHPALKLGITLQVSFLALLGPLGAAAPNPAFVVMSEYFEMSVTEISYELTIFLLFAGIGPLVATPLANHYGRRPVYLLGNLIAAITNIIPGYFDSWAVIMTTRALNGLTAGSVMAMGAATICDMYFAHQRGLFMGIYTLCLTNGSNVAPIIGGFAAETLGWHSCFFIPGYLQLGTFIITLFCLPETLYHADPEDPEAASRKERSYLENLTFRRNNIPARPLHLRDLLTPFKMLTSLSILLPALLYMTCFGYGTVLFALTGAALFTELESTSWVGSAFGMGISNMGLQITTTTIYVYTTDCYKPQSAEISTIMNIFRQVFSCLVSFYAFPLVDLVGIQNTWIIFAMIVVAFMVPVVALRYFGARWRSLANQQLPPSASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6H1</accession>
    <name>A0A0G4P6H1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Mediator of RNA polymerase II transcription subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Mediator complex subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S006g000466</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Mediator complex subunit 6 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P6H1"/>
    <dbReference type="STRING" id="1429867.A0A0G4P6H1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.580:FF:000003">
        <property type="entry name" value="Mediator of RNA polymerase II transcription subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.580">
        <property type="entry name" value="Mediator complex, subunit Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007018">
        <property type="entry name" value="Mediator_Med6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016612">
        <property type="entry name" value="Mediator_Med6_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038566">
        <property type="entry name" value="Mediator_Med6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13104">
        <property type="entry name" value="MED-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04934">
        <property type="entry name" value="Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013286">
        <property type="entry name" value="MED6_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0010">Activator</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="178"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="269"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR013286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL21926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="338" mass="36175" checksum="7FCB85D889D49F99" modified="2015-09-16" version="1">MASQDASMEEILWRSPPHVQMMGGFLHSNNILFYFAESPFFDSTSNNASLAIQANYNDAFRHFVETREAFEARLKTMQGLEFIVSYDPLQAAAQTDNRFAHEPSNIWVIRKQNRRKRSGMDDEVTVISTYFIVGDCIYMAPSVASVVGNRILSAVTSLTQLMKSAATLPTFTASHGHTYLPPGVRSKEGAGTSQASQSKEATPMPDASFPTTESSQATGKSSLGGSTTSSSYQDTRSLAESFSLLTRYGDEFMDESPLVGEPGSFILSRTGGETTGSAVKGAPKIAANAAPTSTPSALPARASTPQVRVDTPGKASEKSSPPSSAGDKGKKKKSRIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6R1</accession>
    <name>A0A0G4P6R1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aromatic-ring hydroxylase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S006g000439</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P6R1"/>
    <dbReference type="STRING" id="1429867.A0A0G4P6R1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="4"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL21899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="425" mass="47036" checksum="280A33F02DB03B5A" modified="2015-09-16" version="1">MFRIAIIGGGIGGLFAALSIEHHCGLNDIQIDIYEQAPEYGEIGAGVGIGPNAAELVKKLGLLGEALKIAGDRQGIWLSFRRYDTGAEVHTVKTPTEGNTAQLPMHRAEFLEILVRAVESRGAATLHTNKHCQTLEDHGDKMSITFIDGTMTTADLVIGADGIHSAVRSQYVNDSAQYGEMVVYRGLCDMDKIKDSWTLPTFAAIFMAPGKHFLTFPISNNKILNVVGFVTTPWEKVGDTKESWTLASEKAAIEEEFKDFAPAVQTVIENMDTNPMKWILFDRKTSPEWIFSGGKVVLLGDAAHAMCPHQGAGAGQALEDGYIIGRALQEYFRPQSTSRRCTIEHCLRLYHSIRYPRSERVQMTSREAGDIYEMKIDGVAGLSYDDGLPVAKAMLEDRMKWIWNEDIDEVYVKALAGWQHSYASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6R8</accession>
    <name>A0A0G4P6R8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S007g000001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P6R8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL22020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="43" mass="5021" checksum="91834188FE9B644D" modified="2015-09-16" version="1">MPPIRSQRSTNSTEQEVPRTTLRHRLSGIQYRAISRANLRKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P856</accession>
    <name>A0A0G4P856_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">General transcription and DNA repair factor IIH subunit TFB5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S007g000425</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="function">
        <text evidence="9">In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the 7-subunit TFIIH core complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the TFB5 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P856"/>
    <dbReference type="STRING" id="1429867.A0A0G4P856"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006294">
        <property type="term" value="P:nucleotide-excision repair, preincision complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1220:FF:000002">
        <property type="entry name" value="RNA polymerase II transcription factor B subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1220">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035935">
        <property type="entry name" value="TFB5-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009400">
        <property type="entry name" value="TFIIH_TTDA/Tfb5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28580">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28580:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06331">
        <property type="entry name" value="Tfb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01395">
        <property type="entry name" value="Tbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142897">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL22444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="72" mass="8529" checksum="2A3CA917F039A937" modified="2015-09-16" version="1">MPRAVRGLLIECDPSIKSMILKYDEERHDYIVEDLDDENHLVIKESQLQNLKVRLDQDLDEKIMQLDESESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P861</accession>
    <name>A0A0G4P861_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="10">1.3.1.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PCAMFM013_S007g000463</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>5,6-dihydrouridine(16) in tRNA + NAD(+) = uridine(16) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53380"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:53382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>5,6-dihydrouridine(16) in tRNA + NADP(+) = uridine(16) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53376"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:53378"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6-dihydrouridine(17) in tRNA + NAD(+) = uridine(17) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53372"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:53374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>5,6-dihydrouridine(17) in tRNA + NADP(+) = uridine(17) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53368"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:53370"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Dus family. Dus1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.88" evidence="10"/>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P861"/>
    <dbReference type="STRING" id="1429867.A0A0G4P861"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF5">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(16_17) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="19">
        <location>
            <begin position="41"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="336"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="480"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="342"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="484"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CRL22482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="536" mass="59659" checksum="0858339AA2C51034" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P8B2</accession>
    <name>A0A0G4P8B2_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heme-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S007g000526</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P8B2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="entry name" value="Haem-degrading domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052517">
        <property type="entry name" value="GlcG_carb_metab_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34309:SF1">
        <property type="entry name" value="PROTEIN GLCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34309">
        <property type="entry name" value="SLR1406 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="HbpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="GlcG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL22545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="25062" checksum="6F2A906B73722619" modified="2015-09-16" version="1">MMLWFLFEKVPSEHREYAQVAWSADRFKHYRAFREVRKELTLCSFHTIVIIINKVPICVITMRNAGSLAVALAAAFLSESTFALINNPMKPPNERFVLNAQQALIAVEAASAKAAANNAPSTIVVADPYGFPIAILRMDNAFIESVDTCIKKTSTVSLFNGALTSGDLQPLVQPGREDYGIEHTNGGMLPIPGAIPLFINGTFFAAIGACGGSGDQDIEAATAGVFAVGGTLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P8W4</accession>
    <name>A0A0G4P8W4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S008g000192</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P8W4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL22763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="36" mass="3799" checksum="71BD54DBA3143AF8" modified="2015-09-16" version="1">MYKFGTLKLNVIPEPVRLDVAVKNGLGGADGVDSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P8Y9</accession>
    <name>A0A0G4P8Y9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="8">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S008g000210</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="8"/>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P8Y9"/>
    <dbReference type="STRING" id="1429867.A0A0G4P8Y9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1150:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016325">
        <property type="entry name" value="Phstyr_phstse_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0697">Rotamase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL22781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="419" mass="46372" checksum="B40C548ED4FF16E0" modified="2015-09-16" version="1">MASQASLPSPTGKVDLSKKLSDLRSNTRRANPNSRDLTPATPPLPSPPDLSTHQYRQPTRRILSAKDHELFLSSPTYKLVLAFVFGLTDSVRGHSITDLQKKPQSESISKVLSVVTQIRSLLAKNPPIDQGGSRFGNPAFRALCDDVSAQSASWHANILGLKDPGATEEASTYLINCLGSRERIDYGSGHELNFMMWLLCLYQLGLLPASDFPAVVIKVYVEYMHLMREIQSAYYLEPAGSHGVWGLDDYHFLPFLFGASQLVGHPYITPLGIHNTAILDEEGDNYLYLDQVRWVESVKTVKGLRWHSPMLDDISGSKNWTKVESGMKKMFVKEVLGKLPIMQHFLFGSLLPAAEGMTDPSEADSEHDDHAHAHGHDHPHESADWFGDCCGIKVPSTVAAGAEMRKRMGGSNLRPIPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P8Z8</accession>
    <name>A0A0G4P8Z8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S008g000227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL23299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="412" mass="46118" checksum="8EE19E09B551D278" modified="2015-09-16" version="1">MTMALRRPHRKSRHGCVECKRRRVKCDESRPSCTNCAHRHAECEYGSSSSLLWANDGSDSGQTGEPVSGLRSPSSPTTGVAAAESLGILTQLSSETATTSPGSALNLNDLELMIQWCDTTFRALSRNERTDPIWRTIVPEEALSHPFLMHGILALSSLHLARTGPEPTRRGSYLNRAVAHQNQALALFREMLGDVNESNAKAMFAFAGIVVIYTFAFPHTPGAQDPWDTVDDLYQVLVLTRGVQQVIHAPRDFTSFLVDSSFGPILQVEETQGAMPTDTIAMLKQLREANKVCGARDPNHELQVYEGSIANLEEMLSWCHSGMRANTIAGRWAICLKPRFMELLRERDPLALVMLAHYGVLLQYLKHRWCFDEWCVRVSKAVWAILDDQWRPLIQWAMKEILGVNFLEQVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAP3</accession>
    <name>A0A0G4PAP3_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">60S acidic ribosomal protein P0</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S009g000279</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. uL10 forms part of the P stalk that participates in recruiting G proteins to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PAP3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PAP3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05795">
        <property type="entry name" value="Ribosomal_P0_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050323">
        <property type="entry name" value="Ribosomal_protein_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030670">
        <property type="entry name" value="uL10_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039087">
        <property type="entry name" value="L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="7">
        <location>
            <begin position="109"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="284"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR039087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL23339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="312" mass="33028" checksum="4010EF3AA3D33A9E" modified="2015-09-16" version="1">MGGKSATKTAYFEKLRALLNEYSTIFIVGVDNVSSQQMHEIRISLRGEAVVLMGKNTMVRRALKGFVAENPEWERLLPHVRGNVGFIFTNGDLKATKEKILANRVAAPARAGAVAPDDVWIPGGNTGMEPGKTAFFQALGVPTKIARGTIEIVSDLKLVEAGNKVGASEATLLNLLNISPFTYGMAITQVYENGQCFGADVLDITDEQLLAAFSQAISTITAVSLAANYPTLPSVIHSLINGYKKVLAAAISTDYSWAEIDDLKDRIANPDAYASAAPAAAAATSGGDAPAAAAPAEEEEESDEDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAQ9</accession>
    <name>A0A0G4PAQ9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SNF2-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S009g000325</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4PAQ9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF26">
        <property type="entry name" value="FAMILY HELICASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="1812"/>
            <end position="1853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1083"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1331"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1359"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1426"/>
            <end position="1446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL23385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="2064" mass="231270" checksum="1057B973594509A1" modified="2015-09-16" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
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                <person name="Abraham A.L."/>
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        <source>
            <dbReference type="EMBL" id="CRL23514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="493" mass="56151" checksum="0ECE0A16582C7171" modified="2015-09-16" version="1">MECFPIISLRSLLPKWVGPFFFQGNPSSVWGDQENQDAESDSILELPNIEVPKIINFWQMPDPRANTAVYKGIENAESSLGPDSILGRIEKLPTELIDSIIEATVFSEPLGSHDALHTLQAFCQEEKDSIFKTRIHTLLRSLSLRKRFETSWELYPDFDHTKTRQRTFDKTAPHDLALKAIVDCPQCFMFLLDHQTIRPSSFYRDGQTLYLIAANSKNPDLIERTMSAIEPLDLLKPISVDGHMTILQFTTQDAQLFQCCWKRLRSTPEIELTLRPTEIMNLCKFADIDLANQLLHRGVDLRIPNPNNGLPNWYQLLYQQNPEPMLGWFWSHDEEVPEDLLTYAARRNCVAGVVWISNHTESHDDWRQAVSVAADKVERESAEIFEFLIQHPPPGYGRDGTGRTDRTLSEDLLITIVGRACSKSRIYDLLLSDECSNSDIQRLQSDKAWLEEVAVQKIQTIQGLNETAGVVGIKVQARKAGLKLVTEALETFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBS7</accession>
    <name>A0A0G4PBS7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
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    <gene>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
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        <property type="entry name" value="zf-C2H2_AcuF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF7">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF26082">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
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            <end position="441"/>
        </location>
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        <location>
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        </location>
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        </location>
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        </location>
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        </location>
    </feature>
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            <begin position="401"/>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        <location>
            <begin position="678"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL23735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="880" mass="102143" checksum="EDABCE60222D763F" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBT6</accession>
    <name>A0A0G4PBT6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Maintenance of telomere capping protein 1</fullName>
        </recommendedName>
    </protein>
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    </gene>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793143">
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    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PBT6"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="DUF5427"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28265">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28265:SF1">
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    </dbReference>
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    </dbReference>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="86"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PC16</accession>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Dupont J."/>
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                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
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                <person name="Lacoste S."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL23852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="79" mass="8711" checksum="AFA35876FF41E3DE" modified="2015-09-16" version="1">MIEMVKVILKNLTSGLPAEWNCPTGVFDELMINPSAPLRLLHYAPQSIKQANQFGVDEHTDFGNVSILLQEEGTEGLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
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    <name>A0A0G4PCK4_PENC3</name>
    <protein>
        <submittedName>
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        </submittedName>
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    <organism evidence="4 5">
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        <lineage>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PCK4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PCK4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="51"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="84"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="117"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="150"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="183"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL24038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="262" mass="28725" checksum="413B8BE6936F2BC1" modified="2015-09-16" version="1">MQNPTPILPAEILLLIARQLGPLDLIHLARAIPGMDRDYKPKYWTIAKDEAGDTMFHIASVNGWDDIIESLLTKNFDFSIQNSRGYTALHYACESDQYKTASLLLDAGLSPNILAKNGMAALHSAIAKGNTSIVRLLLENGADISVITTGGYSMLHWAMQTQKIDIIDLLVINGADFTKEDISGRTPLHWAAADGNMQAVELLLRAGADATSIDHDGYTPADLANQHELSVARRIESVRQRRSPSLAIHALCSVIRWVSAWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCP6</accession>
    <name>A0A0G4PCP6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BolA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S011g000023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PCP6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PCP6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045115">
        <property type="entry name" value="BOL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12735:SF27">
        <property type="entry name" value="BOLA-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12735">
        <property type="entry name" value="BOLA-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL24029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="131" mass="14383" checksum="59E7C69F6060F398" modified="2015-09-16" version="1">MFSRTSSLTVLSRSCRYLLHPNNNIQRASFSLTARSHAAINAAMADTSGITADSLKNKLTEVLQAQHVEVEDLSGGCGQAFQAVIVSPQFESKTMLARHRLVNSALKAEIAAIHAWTPKCYTPEQWQALQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCR6</accession>
    <name>A0A0G4PCR6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S011g000077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PCR6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PCR6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051341">
        <property type="entry name" value="Zyg-11_UBL_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12904">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12904:SF23">
        <property type="entry name" value="PROTEIN ZER-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL24083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="642" mass="71045" checksum="74C17D6CAD9CF3D4" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PD54</accession>
    <name>A0A0G4PD54_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S011g000249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PD54"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL24255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="116" mass="12451" checksum="7AE424F895997CD2" modified="2015-09-16" version="1">MASKAEFKTDASGNRLYTDAKRDLNAAPLLSILNLKHLGYFIQRCSVPTPVANSTGQGYLIPIAKINQTTPATIPGVSLEPGSYIHFASGDKFLVTPEIDCIFVVTPQRQKGTSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDB0</accession>
    <name>A0A0G4PDB0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Autophagy-related protein 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S011g000312</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Interacts with ATG1 to form the ATG1-ATG13 kinase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ATG13 family. Fungi subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PDB0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PDB0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:mitophagy"/>
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</entry>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <authorList>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NWD NACHT-NTPase N-terminal" evidence="4">
        <location>
            <begin position="42"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="293"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="801"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="991"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1623"/>
            <end position="1651"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1786"/>
            <end position="1814"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1815"/>
            <end position="1847"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1854"/>
            <end position="1886"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1883"/>
            <end position="1915"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1965"/>
            <end position="1993"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="2123"/>
            <end position="2155"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="2224"/>
            <end position="2252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL24936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="2640" mass="291371" checksum="2BE24DA04E03A317" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PFS9</accession>
    <name>A0A0G4PFS9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S014g000057</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PFS9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PFS9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051283">
        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF69">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL25161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="497" mass="55018" checksum="D3689A4D8BE284E2" modified="2015-09-16" version="1">MKLPFGRQPIMEPIPGDRVVPLHFFEDSLLVQGNNMAVSLVFDAMLDPERLRESLEDLVKQEGWQRLGGRLRKNASGKIEWHIPAKFSAERPAISFAHVDHGMPAASHPAASRIPKPQDRPCVVGDPDDLEGLAWEPGYKPNGINDYLTSDLPVLGLRVNSFTDKTVVVLQWQHVAFDALGMQYVVEGWSSMLWGKAAEVLIPCGLDSDPFHSLAQGSRPTTEEHVLTDRRVGLVGLLRWGLGYGVDMLVRAKGNRMVCIPETYWRPQWEKAVEELRTEAIANGEDPSKVFLTENDVLTAWILRCVVGEMGMNPERTVAASIAMSLRKSFEGDLLPTSTEHPYVGNAFGWANVLVTAGDVASKPLSWLARQVRRAINEQGTRAQHEAYYAMVRTSGTGLPIVVFGDGGMAQVGFSNWSKAGLFNLDFSPARQGSRDDSLPCRPSYVQENHGPVKPADGFFILGKDEKGNYWTSACKVKGQWAKFEEQLKEFDISGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PFZ2</accession>
    <name>A0A0G4PFZ2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sarcosine oxidase, alpha subunit, heterotetrameric</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S014g000145</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GcvT family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PFZ2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PFZ2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032503">
        <property type="entry name" value="FAO_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF11">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16350">
        <property type="entry name" value="FAO_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase central" evidence="6">
        <location>
            <begin position="381"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="GCVT N-terminal" evidence="4">
        <location>
            <begin position="440"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="5">
        <location>
            <begin position="747"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="831"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="831"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL25249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="850" mass="93237" checksum="FB28DED698CEE577" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PFZ5</accession>
    <name>A0A0G4PFZ5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Esterase, SGNH hydrolase-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S014g000150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PFZ5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01831">
        <property type="entry name" value="Endoglucanase_E_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037461">
        <property type="entry name" value="CtCE2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052762">
        <property type="entry name" value="PCW_deacetylase/CE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37834:SF2">
        <property type="entry name" value="ESTERASE, SGNH HYDROLASE-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37834">
        <property type="entry name" value="GDSL-LIKE LIPASE/ACYLHYDROLASE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G00620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195314" evidence="1">
        <location>
            <begin position="20"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="2">
        <location>
            <begin position="220"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL25254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="400" mass="45033" checksum="01B4A5125A948B92" modified="2015-09-16" version="1">MRLGQTFTAFLSWALVASATILENGQVRENAYPGQLQPVTLDDSWRNYPADAPEISYKGRWDSQHISWWSAPGIKVEFSGEKLAVHFGPSTNTGVLVAYRIGSLDWQFSNITASSTYQFVGPESELKDGDEPVEKNTFEMRVQIAGVAVANGAALTKPPTFEKRVEIIGGSLASGQFATYETLSSWSFLFANGLGNVEYGITAYPGVCLADEQCYNGGSRGVGWYWHRASDPGSRARSIYDRNPEKWDVKAEQPADLVIIQMGGNDHRHPNEIPGRDYYHAYVDLVEDIHSNWPNAIIILMSQWGGFTKEGKKYVGSTYYQEETREVNEHFKDRGFVYYFPTEGLLQHNDINPKNHLTDVGHVKIASHLLQWVKLILRWNLEPTGEVSAGTTYWNDQQEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PG63</accession>
    <name>A0A0G4PG63_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="19">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PCAMFM013_S014g000209</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 19">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="19"/>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4PG63"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090556">
        <property type="term" value="F:phosphatidylserine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000026">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000047">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000010">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF150">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 18 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 17 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 19" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="498"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="548"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1100"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1143"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1179"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1208"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1251"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="21">
        <location>
            <begin position="235"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="22">
        <location>
            <begin position="1029"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="16">
        <location>
            <position position="612"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="612"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="612"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="613"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="614"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="614"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="707"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="748"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="771"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="804"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="885"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="886"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="887"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="977"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="983"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="1003"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="1006"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="1007"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="1007"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CRL25313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1359" mass="152111" checksum="A43D2F2137D515EE" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGJ2</accession>
    <name>A0A0G4PGJ2_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S015g000047</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG793148">
        <property type="protein sequence ID" value="CRL25461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PGJ2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="37"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL25461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="171" mass="19387" checksum="3A7FCBF2D77998E3" modified="2015-09-16" version="1">MASFQERAQHSIAQLDKELSKYPVLANLERQTNVPKVYVILGLVGIYFFLVFFNIAGEFLVNFAGFLVPGYYSLQALFTSSTQDDTQWLTYWVVFAFLTVIESAISAAYWFPFYYIFKFVLIMWMALPQTSGAQIVFHSFLQPVVGRFFSTNGTSSNLRAQAEAAAKPHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGR1</accession>
    <name>A0A0G4PGR1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S015g000011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
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                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
    <dbReference type="EMBL" id="HG793148">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PGR1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL25425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="76" mass="8251" checksum="4C0CF7F4E1230932" modified="2015-09-16" version="1">MSGIRKVSSADRRQSFRARLQHSLSLSSSESDDTHSPSRSVVGDTLEDRSSFQGGDGCYSAQENGNPSDESDRGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PH26</accession>
    <name>A0A0G4PH26_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc finger, C2H2-type/integrase, DNA-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S015g000232</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793148">
        <property type="protein sequence ID" value="CRL25646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PH26"/>
    <dbReference type="STRING" id="1429867.A0A0G4PH26"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002123">
        <property type="entry name" value="C2H2 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001289">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF22">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793149">
        <property type="protein sequence ID" value="CRL25848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PI20"/>
    <dbReference type="STRING" id="1429867.A0A0G4PI20"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF80">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL25848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="168" mass="18745" checksum="D0FD4877EDD79E07" modified="2015-09-16" version="1">MPSLVTIIVQSATLKAFANITAQILQQLKSPTPIPLDWNRVLEFAVFGIVSAPLISLWQRSLDETFPTQNSRINWPNVLLKLLLDQTIGLFVANVVFIICTTGARLQSGTLILQEVQARIFRILLAAWKIWPAVSLVNFLWVPWHSRVVVTSLVGFGWNIILSVLSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PIB9</accession>
    <name>A0A0G4PIB9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial import inner membrane translocase subunit TIM16</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial import inner membrane translocase subunit tim16</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 12">Presequence translocated-associated motor subunit PAM16</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S017g000062</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM16/PAM16 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793150">
        <property type="protein sequence ID" value="CRL26079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PIB9"/>
    <dbReference type="SMR" id="A0A0G4PIB9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PIB9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000006">
        <property type="entry name" value="Import inner membrane translocase subunit TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005341">
        <property type="entry name" value="Tim16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388">
        <property type="entry name" value="MITOCHONDRIA ASSOCIATED GRANULOCYTE MACROPHAGE CSF SIGNALING MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03656">
        <property type="entry name" value="Pam16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CRL26079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="135" mass="15186" checksum="FF284C6EABABC465" modified="2015-09-16" version="1">MAHRIVSQVVVTGARVFGRAFAEAYKQAQASGKYAGQQKAAGKSTSTSSVTIDEACKILNVKPPASGEHDLEHVMTRFKKLFDTNNPEKGGSFYLQSKILRARERLEMEFREVERKAAHDKELKEGWNPKVYKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PIG2</accession>
    <name>A0A0G4PIG2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glia maturation factor beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S016g000262</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the actin-binding proteins ADF family. GMF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793149">
        <property type="protein sequence ID" value="CRL25981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PIG2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PIG2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071846">
        <property type="term" value="P:actin filament debranching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034316">
        <property type="term" value="P:negative regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11283">
        <property type="entry name" value="ADF_GMF-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000048">
        <property type="entry name" value="Putative gmf family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011171">
        <property type="entry name" value="GMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249:SF2">
        <property type="entry name" value="GLIA MATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249">
        <property type="entry name" value="GLIAL FACTOR NATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001788">
        <property type="entry name" value="GMF-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="3">
        <location>
            <begin position="4"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR001788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL25981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="141" mass="16105" checksum="25989E995C3FCD66" modified="2015-09-16" version="1">MSDSRLYSFSPETKEKLRKFRLGTSRAKDAQAIIYIIDAKSQEIRPQDDTVYSNMEDLADDLPESSPRFILLSHPMTTKDGRPSVPYVLLYWLPENCNPMQRMSYANAVELMRTSAQVNRVIEVEADEDIVNIKSKLTGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PIG8</accession>
    <name>A0A0G4PIG8_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha N-terminal protein methyltransferase 1</fullName>
            <ecNumber evidence="5">2.1.1.244</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Translation associated element 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">X-Pro-Lys N-terminal protein methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S017g000112</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54712"/>
            <dbReference type="Rhea" id="RHEA-COMP:13785"/>
            <dbReference type="Rhea" id="RHEA-COMP:13971"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138057"/>
            <dbReference type="ChEBI" id="CHEBI:138315"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine = N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54736"/>
            <dbReference type="Rhea" id="RHEA-COMP:13787"/>
            <dbReference type="Rhea" id="RHEA-COMP:13974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138059"/>
            <dbReference type="ChEBI" id="CHEBI:138318"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54724"/>
            <dbReference type="Rhea" id="RHEA-COMP:13789"/>
            <dbReference type="Rhea" id="RHEA-COMP:13973"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138061"/>
            <dbReference type="ChEBI" id="CHEBI:138317"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. NTM1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.244" evidence="5"/>
    <dbReference type="EMBL" id="HG793150">
        <property type="protein sequence ID" value="CRL26129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PIG8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PIG8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071885">
        <property type="term" value="F:N-terminal protein N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000025">
        <property type="entry name" value="N-terminal Xaa-Pro-Lys N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008576">
        <property type="entry name" value="MeTrfase_NTM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753">
        <property type="entry name" value="AD-003 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753:SF0">
        <property type="entry name" value="ALPHA N-TERMINAL PROTEIN METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05891">
        <property type="entry name" value="Methyltransf_PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016958">
        <property type="entry name" value="DUF858_MeTrfase_lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR016958-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL26129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="260" mass="28954" checksum="BAD9D5FBB4E6CF59" modified="2015-09-16" version="1">METGYGALPITGPFQRVNIVKTSNMTDSNTPADSQINHAESLKYWNSVPATTGSMLGEFPSVSRIDLQGSKTFLAKIRRLIPGVQSEGKFHQGVDCGAGVGRVTEGFLSHVCDVVDAVEPIAKFTQVMKDSQLKRDGIIGTIYTRGLENWTPEKKYDLIWVQWCVGHLTDSQLIDYTVRCRKALTETGLMVLKENLSTHFSGEDMYDSEDSSVTRTDAKFRQVFEAAGMEIVKSELQRGFPSSLRMLPVQFYALRPKTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PIQ3</accession>
    <name>A0A0G4PIQ3_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="16">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PCAMFM013_S017g000039</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">May mediate the reduction of outer membrane cytochrome b5.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 16">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="16"/>
    <dbReference type="EMBL" id="HG793150">
        <property type="protein sequence ID" value="CRL26056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PIQ3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PIQ3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000032">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000009">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF101">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15 16" id="KW-0274">FAD</keyword>
    <keyword evidence="4 15 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="10 16" id="KW-0520">NAD</keyword>
    <keyword evidence="9 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="17">
        <location>
            <begin position="53"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CRL26056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="296" mass="32470" checksum="1A04760460780FAF" modified="2015-09-16" version="1">MFTMFRTRLPQSITAKSATAVTLLGVGAYCAQSRLISTANAESNEPPKVFSGFGFTTLRLQSTKDVNHNTKRLVFEFPDQNATSGLSLTSALLTISRPEGRWFPVLRPYTPISDLNQQGQIEFMVKKYPNGKASSHIHSLAPGDTLTFAAALKGHAWTPNQSPQIYLIAGGAGITPIYQLAQGILNNPADKTKINLVFGVNTEKDLLVREELESFKTRFPGRFDYVYTVSHPEGQSDDFRKGYVTEELLRDVVKADGDAMVFVCGPPAMEDSLVGSRSKTGILDRLGFAKGQIVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJJ8</accession>
    <name>A0A0G4PJJ8_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.256</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Asparagine-linked glycosylation protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PCAMFM013_S019g000023</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the third and last glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(2)Man(9)GlcNAc(2)-PP-Dol to produce Glc(3)Man(9)GlcNAc(2)-PP-Dol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate = a alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29543"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="Rhea" id="RHEA-COMP:19512"/>
            <dbReference type="Rhea" id="RHEA-COMP:19522"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:132522"/>
            <dbReference type="ChEBI" id="CHEBI:132523"/>
            <dbReference type="EC" id="2.4.1.256"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:29544"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ALG10 glucosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.256" evidence="4"/>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJJ8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJJ8"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106073">
        <property type="term" value="F:dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016900">
        <property type="entry name" value="Alg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12989">
        <property type="entry name" value="ALPHA-1,2-GLUCOSYLTRANSFERASE ALG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12989:SF10">
        <property type="entry name" value="DOL-P-GLC:GLC(2)MAN(9)GLCNAC(2)-PP-DOL ALPHA-1,2-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04922">
        <property type="entry name" value="DIE2_ALG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="373"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="564"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="628"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="451"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="459"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="493"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="507"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CRL26607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="668" mass="75694" checksum="F6A7B18579D15F8F" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJP5</accession>
    <name>A0A0G4PJP5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Meiotically up-regulated gene 154 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S019g000064</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJP5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJP5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043007">
        <property type="term" value="P:maintenance of rDNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018819">
        <property type="entry name" value="Nur1/Mug154"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28293">
        <property type="entry name" value="NUCLEAR RIM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28293:SF1">
        <property type="entry name" value="NUCLEAR RIM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10332">
        <property type="entry name" value="DUF2418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="321"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="409"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="354"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL26647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="50652" checksum="1135A3364B569CC1" modified="2015-09-16" version="1">MPRLVRRRPLSERILSHLNPYDFLLWLSEEFEAGDWDQLEKNWALPIGIALNVIFLIARANSRSGGSKAFDDVFGDGDGTSLRGWLASFIVHLMAVASTANALYTFQKKRHYRLFENSIDNNPATPSAHRVRVDSSPMMPSPLRYIAKALSSESAHSRAHPDAQRDVWELAIWDPSPLCLRLFCLFSPGHVLVYWLFLPTQLSDPRPSVTIVTTIVLTALLSVQMSFISSSYTQQAKDQKVIHKEVFKEYDTKYVQPRTHPLMRDVGTQFSDPYGGPPKTEDECNRVETYSPAHIINRGFKTSPNPNYLKHVDPEGFTPVRQSTASTPISSIFQGPPTNTPSMSRDGSPMARGTSRTTMRQPQFRSTTTTGGDGGSLGVYSHANSPLRKSATTSFDRRLQNNGDFVYKERGTTPLMRSSSPLKRSSVPGGMNPGGPATVNRSDNLNTRRETGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKE6</accession>
    <name>A0A0G4PKE6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Transcription elongation factor SPT5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S020g000026</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the SPT4-SPT5 complex. Interacts with RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SPT5 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793153">
        <property type="protein sequence ID" value="CRL26867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKE6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PKE6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06081">
        <property type="entry name" value="KOW_Spt5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06082">
        <property type="entry name" value="KOW_Spt5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06083">
        <property type="entry name" value="KOW_Spt5_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06084">
        <property type="entry name" value="KOW_Spt5_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06085">
        <property type="entry name" value="KOW_Spt5_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09888">
        <property type="entry name" value="NGN_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000018">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000029">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="entry name" value="NusG, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041973">
        <property type="entry name" value="KOW_Spt5_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041975">
        <property type="entry name" value="KOW_Spt5_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041976">
        <property type="entry name" value="KOW_Spt5_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041977">
        <property type="entry name" value="KOW_Spt5_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041978">
        <property type="entry name" value="KOW_Spt5_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057936">
        <property type="entry name" value="KOWx_Spt5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005100">
        <property type="entry name" value="NGN-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039385">
        <property type="entry name" value="NGN_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039659">
        <property type="entry name" value="SPT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024945">
        <property type="entry name" value="Spt5_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022581">
        <property type="entry name" value="Spt5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017071">
        <property type="entry name" value="TF_Spt5_eukaryote"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125">
        <property type="entry name" value="SUPPRESSOR OF TY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125:SF7">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12815">
        <property type="entry name" value="CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23042">
        <property type="entry name" value="KOW1_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23284">
        <property type="entry name" value="KOW2_Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23291">
        <property type="entry name" value="KOW4_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23290">
        <property type="entry name" value="KOW5_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23037">
        <property type="entry name" value="KOWx_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03439">
        <property type="entry name" value="Spt5-NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11942">
        <property type="entry name" value="Spt5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036945">
        <property type="entry name" value="Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01104">
        <property type="entry name" value="CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="KOW" evidence="11">
        <location>
            <begin position="300"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="11">
        <location>
            <begin position="459"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="11">
        <location>
            <begin position="512"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="11">
        <location>
            <begin position="635"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="11">
        <location>
            <begin position="724"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="Spt5 C-terminal" evidence="12">
        <location>
            <begin position="832"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="766"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="902"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="873"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="904"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="941"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="986"/>
            <end position="1007"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR036945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL26867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1025" mass="111129" checksum="77F014AD6A67B023" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PLK9</accession>
    <name>A0A0G4PLK9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">TATA-binding protein-associated factor mot1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Modifier of transcription 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NCT transcriptional regulatory complex subunit mot1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PCAMFM013_S021g000174</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Regulates transcription in association with TATA binding protein (TBP). Removes TBP from the TATA box via its C-terminal ATPase activity. Both transcription activation and repression require its ATPase activity. Part of the NCT transcriptional regulatory complex that acts as a key regulator of ergosterol biosynthesis and the azole exporter cdr1B. The NCT complex binds the promoters of genes linked to azole susceptibility, and especially represses the expression of cdr1B transporter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Forms the NCT transcriptional regulatory complex with nctA and nctB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
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        <property type="protein sequence ID" value="CRL27259.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17999">
        <property type="entry name" value="DEXHc_Mot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000009">
        <property type="entry name" value="B-TFIID TATA-box-binding protein-associated factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000508">
        <property type="entry name" value="Probable helicase mot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000445">
        <property type="entry name" value="Related to MOT1-transcriptional accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000428">
        <property type="entry name" value="TATA-binding protein-associated factor 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
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    </dbReference>
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        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="1332"/>
            <end position="1505"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="1679"/>
            <end position="1830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="185"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="709"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="272"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00064550"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00073046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00081329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CRL27259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1908" mass="212292" checksum="285145A85BBD5739" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PLU0</accession>
    <name>A0A0G4PLU0_PENC3</name>
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        <submittedName>
            <fullName evidence="5">14-3-3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S021g000063</name>
    </gene>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 14-3-3 family.</text>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="4">
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            <begin position="5"/>
            <end position="246"/>
        </location>
    </feature>
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            <begin position="233"/>
            <end position="284"/>
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    </feature>
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            <begin position="270"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL27148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="284" mass="31593" checksum="CB938A086444FEDE" modified="2015-09-16" version="1">MGSERENKTFLARLCEQAERYDEMVTFMKEVANIGGELTVDERNLLSVAYKNVVGTRRASWRIISSIEQKEENKGSDEHVGIIRDYRQKIETELEQVCQDVLDVLDEALIPKAETGESKVFYYKMKGDYHRYLAEFASGPKRKGAATAAHEAYKNATDVAQTELTPTHPIRLGLALNFSVFYYEILNSPDRACHLAKQAFDDAIAELDSLSEESYRDSTLIMQLLRDNLTLWTSSEGTEGESAAKEEKSEEEPAAPAAPAAASTEAAAPAEEKPEEAKPAETEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PLY9</accession>
    <name>A0A0G4PLY9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S022g000115</name>
    </gene>
    <organism evidence="3 4">
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793155">
        <property type="protein sequence ID" value="CRL27435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PLY9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PLY9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022185">
        <property type="entry name" value="DUF3712"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046368">
        <property type="entry name" value="Tag1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12505">
        <property type="entry name" value="DUF3712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL27435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="448" mass="48855" checksum="FBA6BEB08475AADB" modified="2015-09-16" version="1">MVLGIGKYIIGGNRGLLKPDSDESRGPEKVGSVSSTSKKNKFRRHCRRFWCIYLIANVIFLAIFLPVFFLVALPAIAQLVVNKSDLRIVNAEVMHPTADTVRMTLEAKVNLKLAMGVRLDPVVFYTFVRSTGHKNAYAGIKIPGQTIKGNYSLGVTDQLTQILNMTSWETIVSQAVFQKETALSLYGVTTGYLGVLKNHIVLDKDVAIPSEYFTRVVFHPWTVLLIFEIALNKFADFSIANSTFLLPSENDGSNLVANITLPNPSALSFEVGTITLDLKSGNTDLIIGKATVKDVTLRPGNNTFPLRGVIDIGTMIGNLTEVLSSQGPAIRRGALSLTAVTKSIVSNGTLIPYYTKVLSSLPLVANVSIGEVLSNSLAHLGSSETLSDSDDKRRRGPVQLDGPVGYGDAYTQVASLKHNRHVQKIFENENPEQRDAIIDSLAQYYAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMF4</accession>
    <name>A0A0G4PMF4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S021g000236</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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    <protein>
        <recommendedName>
            <fullName evidence="4">deuterolysin</fullName>
            <ecNumber evidence="4">3.4.24.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PCAMFM013_S027g000045</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential cleavage of bonds with hydrophobic residues in P1'. Also 3-Asn-|-Gln-4 and 8-Gly-|-Ser-9 bonds in insulin B chain.</text>
            <dbReference type="EC" id="3.4.24.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M35 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.39" evidence="4"/>
    <dbReference type="EMBL" id="HG793160">
        <property type="protein sequence ID" value="CRL28356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQG0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PQG0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11008">
        <property type="entry name" value="M35_deuterolysin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050414">
        <property type="entry name" value="Fungal_M35_metalloproteases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029463">
        <property type="entry name" value="Lys_MEP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001384">
        <property type="entry name" value="Peptidase_M35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016:SF3">
        <property type="entry name" value="NEUTRAL PROTEASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14521">
        <property type="entry name" value="Aspzincin_M35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00768">
        <property type="entry name" value="DEUTEROLYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 16" id="KW-0732">Signal</keyword>
    <keyword evidence="11 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007012688" description="deuterolysin" evidence="16">
        <location>
            <begin position="20"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Lysine-specific metallo-endopeptidase" evidence="17">
        <location>
            <begin position="64"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601384-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601384-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF14521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CRL28356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="205" mass="21821" checksum="EBCE7F0D6471AC78" modified="2015-09-16" version="1">MQFTFALFAAAALLTPVYSNEITPMSRRETGIKLESCTTSQQAVVEAAVQRAASLAKAAADAAINGDASIFEDGKVTYNCGNGTTQSDCGGNGVLAYALSGNNKIVNCPSWYKIVPAIDDCGGTDQGLAMVHELSHMNEVYSPPTQDFAYKYNDLVQLPTEQAVLNADTYNLYAGAIDLGCQVGESKGVVLPDWMVTEIMNNNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRE3</accession>
    <name>A0A0G4PRE3_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S032g000006</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTH2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="HG793165">
        <property type="protein sequence ID" value="CRL28970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PRE3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PRE3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02430">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1490.10:FF:000001">
        <property type="entry name" value="Peptidyl-tRNA hydrolase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649:SF11">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL28970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="209" mass="22548" checksum="9A69D497C4D091AE" modified="2015-09-16" version="1">MAAPVPLDRIPPTTAAYVIATAIIAGVTGYFIGQGSSISLFKEKEGWPNSYDVKVHSHSSDEEDESDSEEEETDEEDEGNGEELSSFKDNSEEVKLVLVVRMDLGMTKGKIAAQCGHATLACYKYFLEYAPNSPILKKWERGGQAKIALQVRSEDELLVMQAQAISLGLCTRVIQDAGRTQIASGSKTVMGVLGPKSVVDGVTGHLKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRI2</accession>
    <name>A0A0G4PRI2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S032g000051</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793165">
        <property type="protein sequence ID" value="CRL29015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PRI2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PRI2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF281">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE NAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="3">
        <location>
            <begin position="76"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="4">
        <location>
            <begin position="131"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL29015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="346" mass="38125" checksum="DFAE3F9EEBD54968" modified="2015-09-16" version="1">MAEIPTVLLVESTVQQIDHVRRQTLSEKVTILKYDCASVDDFIARLQPGGLYSNICAIVRTGWLKAGPYASHRLFASEVIPHFPSSLKLICCSGHGYDAADIDALTNRGIWFCNTPNACTEAVANTGLVLVLETFRYLSFAQWCARYDWQKSRELGLKAVDPAGMVLGVIGLGDIGLAIAEKCQNALGMKIVYHGPRRKEEAETRLGGGAQYYADLTDMISAVDCIVIAAPYTQSTHHLLSHKQFQVTKDTGLRVVNIARGKMIDEDALVLALEMGKVVGVGLDVHENEPVVHEKLRENWMVTLLPHIGVCSKTSWANFERQTWDNLESFLQTGKPACPVNMIKGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRQ6</accession>
    <name>A0A0G4PRQ6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S030g000088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793163">
        <property type="protein sequence ID" value="CRL28801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PRQ6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PRQ6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL28801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="256" mass="30316" checksum="85676259F6D6415F" modified="2015-09-16" version="1">MEETIAELRRQLEEERQAREEAQRREEEERQAREEAERLQGEAERRLEPNTLFRLLDRCHNSLSQAIRVETDATLTTQGDATDPVNRLYPKRVVPWLDFPQLQEKIWRKFDRTGAFTSRPLFPSDTQIDYILTNVQNRPIYSEASLRNFERDTVDNFVEKAIMALRDNEPLRHEFGIQGRVTFYDRVNPSETSLEKSLEQMNLQGTRTPQRVANTRHRRGRGMGRGVAQGQKRDSTTRRRNRRADQFYVHLMADER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRW1</accession>
    <name>A0A0G4PRW1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S031g000031</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="HG793164">
        <property type="protein sequence ID" value="CRL28863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PRW1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PRW1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000123">
        <property type="entry name" value="Protein phosphatase 2C homolog 7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE PTC7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13672">
        <property type="entry name" value="PP2C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="127"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="369"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="377"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL28863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="462" mass="49432" checksum="77C89053FAB5DDE7" modified="2015-09-16" version="1">MIPPSVSCRACSSACSSLQAIVRDGAYSISTNPSTYTPSLFKAQRVRLSSHVARLRPDTRLSLNLTRQPSRRAFHATPTTNFEKPSPSNLSYRVAVSSSGKGRRFHPIKNAYNFDPTADALGVSKDKNSVSRRRNRPDSGEDAFFVTRIGNRISDHQDTNAEAVAFGVADGVGGWTESRVDPADFSHGLCNYMAETAQTWHEPAERLRSKYLIQAGYDQVVADPNIRAGGSTASVGVALPDGRVELANLGDSGSVLLRRAAVHHYSVPQTHGFNTPYQLSVIPPRMRAQASVFGGAFLEDFPRDASVTNVQMQHGDVLIIATDGVFDNLNNQDILKLITSRMVMTGAWTATESGVGVSENLRALAAPGGLADALPTPSGSPLSKDPANTESGPEDGVTLQSVLAATIAGEAKIASVDYRRDGPFAKEAQRYHPGDYYRGGKVDDICVVVVIAVEDSVAASEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PS92</accession>
    <name>A0A0G4PS92_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL30m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S032g000012</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793165">
        <property type="protein sequence ID" value="CRL28976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PS92"/>
    <dbReference type="STRING" id="1429867.A0A0G4PS92"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01658">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000010">
        <property type="entry name" value="Large subunit ribosomal protein L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01371_B">
        <property type="entry name" value="Ribosomal_uL30_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_uL30_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01308">
        <property type="entry name" value="rpmD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 10" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="9">
        <location>
            <begin position="4"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL28976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="94" mass="10684" checksum="CF17B1E08E094521" modified="2015-09-16" version="1">MSYFRITLVRSAIGLPRRSTDVLKALGLKKRMATVFHSVSPSVAGQIMKVKELVQVEECQYRLTKQEVHLERKPDPGYYTEKSCTEQRGELGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PSH0</accession>
    <name>A0A0G4PSH0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S035g000022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793168">
        <property type="protein sequence ID" value="CRL29327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PSH0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL29327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="51" mass="5654" checksum="40D64E03EBB4D020" modified="2015-09-16" version="1">MVNVAQGLADMYIFKLAYCLALSPIVTMRMLSGIARGDFTVRNFPTLSRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PSI5</accession>
    <name>A0A0G4PSI5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Indigoidine synthase A like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S033g000021</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793166">
        <property type="protein sequence ID" value="CRL29101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PSI5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01941">
        <property type="entry name" value="YeiC_kinase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1790.10">
        <property type="entry name" value="Indigoidine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01876">
        <property type="entry name" value="PsiMP_glycosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022830">
        <property type="entry name" value="Indigdn_synthA-like"/>
    </dbReference>
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        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007342">
        <property type="entry name" value="PsuG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909:SF1">
        <property type="entry name" value="CARBOHYDRATE KINASE PFKB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909">
        <property type="entry name" value="ZGC:136858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04227">
        <property type="entry name" value="Indigoidine_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110581">
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    </dbReference>
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        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="6">
        <location>
            <begin position="392"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL29101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="796" mass="83517" checksum="91CC7197C8A79E03" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PSY2</accession>
    <name>A0A0G4PSY2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S034g000059</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793167">
        <property type="protein sequence ID" value="CRL29261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PSY2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PSY2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF5">
        <property type="entry name" value="ANCHORED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195943" evidence="3">
        <location>
            <begin position="19"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="28"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL29261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="240" mass="23842" checksum="64A7E4B9EEB50DCB" modified="2015-09-16" version="1">MRFFTSLAIAAMAAVVSANSKANPFSIPTDGYTFTTGESTALKWEPTTTGTVSLILQWGAVLTGNTGTVIASNIANDGSYTWSVPSKLAAEPDYTIKIVSDDDSNDYNYIGRFTVEGATVTVSSSSASSTATSTSTESSSTESSTSATRTSTGTSTSETSASSSSAITTGSTTLTTASSTVASTSASATSTSESSSTAESTSTSASSSAASQSAVPTTNAGIANRVSGGMLAIVAGALML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PSY9</accession>
    <name>A0A0G4PSY9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S036g000084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <authorList>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        </source>
    </evidence>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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    <accession>A0A0G4PY76</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF21">
        <property type="entry name" value="DYNAMIN RELATED PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="5">
        <location>
            <begin position="37"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="4">
        <location>
            <begin position="608"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="741"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="741"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="780"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL31147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="803" mass="88856" checksum="5F918A31C0F4E9D1" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NTU8</accession>
    <name>A0A0G4NTU8_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">nitric oxide dioxygenase</fullName>
            <ecNumber evidence="4">1.14.12.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PCAMFM013_S001g000447</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">In the presence of oxygen and NADH, it has NADH oxidase activity, which leads to the generation of superoxide and H(2)O(2). Under anaerobic conditions, it also exhibits nitric oxide reductase and FAD reductase activities. However, all these reactions are much lower than NOD activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 nitric oxide + NADH + 2 O2 = 2 nitrate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19469"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 nitric oxide + NADPH + 2 O2 = 2 nitrate + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.17" evidence="4"/>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NTU8"/>
    <dbReference type="STRING" id="1429867.A0A0G4NTU8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008941">
        <property type="term" value="F:nitric oxide dioxygenase NAD(P)H activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071500">
        <property type="term" value="P:cellular response to nitrosative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046210">
        <property type="term" value="P:nitric oxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08922">
        <property type="entry name" value="FHb-globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06184">
        <property type="entry name" value="flavohem_like_fad_nad_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.490.10:FF:000003">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000034">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000010">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009805">
        <property type="entry name" value="PRK13289.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396:SF3">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0216">Detoxification</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Globin" evidence="17">
        <location>
            <begin position="6"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="18">
        <location>
            <begin position="153"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00056398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CRL17487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="419" mass="46292" checksum="6307387BB0A7E3A7" modified="2015-09-16" version="1">MGSNPGMTPDQIALIKATIPVLVEHGNTITTVFYRNMLEAHPELNTVFNTANQVNGHQPRALAGALYAYASHIDDLGALSSAVELICNKHASLYIKPEHYNIVGKYLLEAMGEVLGEELTPEIHDAWGTAYWQLADIMIGREKQLYEHAEGWTDWREFKIVNKVQESEEITSFYLAPVDEKPLPAFQPGQYISVQTYVPALKYPQARQYSLSDQPKPDYYRISVKRELGLSPAAPGAAAHPGYISNVLHDTFNVGDKLNVSHPYGDFFLTPADSETGNPIVLISAGVGLTPLTSILNTLISKSPTTRKVHFIHGARSSGARAFKKQITELPKQFPSIRTTFFTSHPSEGETEGVDYDHVGRVDLTKLENQDLFLDDAKTDYYICGPGKFMTDIESVLKAKGVGADRIKMELFGTGGIPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NTY4</accession>
    <name>A0A0G4NTY4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S001g000495</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="5">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GcvH family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NTY4"/>
    <dbReference type="STRING" id="1429867.A0A0G4NTY4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002270">
        <property type="entry name" value="PRK01202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715:SF3">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="66"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="4">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL17535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="170" mass="18099" checksum="2B883DECE94B4781" modified="2015-09-16" version="1">MSSVARAIRPFASRVLTQKPLASACQVAPAFRFPRGTRSFSQSPLSQLKKYTESHEWIELADGGKTAKIGITEYAAHSLGDVVYVELPEVDLEIVAGEPVGAVESVKSASDVLSPVAGKVIKGNSILEDKAKTINESPEGEGWIAEIEVADAAELDALLDEAAYKETIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NU90</accession>
    <name>A0A0G4NU90_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prefoldin subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S001g000611</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NU90"/>
    <dbReference type="STRING" id="1429867.A0A0G4NU90"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23156">
        <property type="entry name" value="Prefoldin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000001">
        <property type="entry name" value="Prefoldin subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016655">
        <property type="entry name" value="PFD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016396">
        <property type="entry name" value="Prefoldin_subunit_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="136"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR016396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL17651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="197" mass="22550" checksum="C9AABDF6AB503656" modified="2015-09-16" version="1">MADSKKSTVTTQTNPRGIPVAPFIDNVSDYVSSREEVEPTLRSFQEMISKYQFMEVNTQRRGQGLREKIPDIKKTLEMVRFLQLRKESNPDSDLETNFELNDTLYARAAISPADAEEVYLWLGANVMLAYPLGEAETMLDEKLNAAESSLQNCEEDLEFLREQITTLEVATARVYNWDVVERRKDKADGKGEEETKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NUI2</accession>
    <name>A0A0G4NUI2_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Clustered mitochondria protein homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein TIF31 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CLU1</name>
        <name evidence="4" type="synonym">TIF31</name>
        <name evidence="8" type="ORF">PCAMFM013_S001g000717</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">May associate with the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CLU family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NUI2"/>
    <dbReference type="STRING" id="1429867.A0A0G4NUI2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd15466">
        <property type="entry name" value="CLU-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000293">
        <property type="entry name" value="Clustered mitochondria protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000532">
        <property type="entry name" value="Clustered mitochondria protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2280.10:FF:000002">
        <property type="entry name" value="Clustered mitochondria protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03013">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033646">
        <property type="entry name" value="CLU-central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025697">
        <property type="entry name" value="CLU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028275">
        <property type="entry name" value="CLU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027523">
        <property type="entry name" value="CLU_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601:SF6">
        <property type="entry name" value="CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13236">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15044">
        <property type="entry name" value="CLU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12807">
        <property type="entry name" value="eIF3_p135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51823">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Clu" evidence="7">
        <location>
            <begin position="323"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="966"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="602"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="863"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1160"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1171"/>
            <end position="1184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL17757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1242" mass="137975" checksum="4B0E05CB3478705C" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NUJ0</accession>
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        </submittedName>
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        <name evidence="8" type="ORF">PCAMFM013_S001g000708</name>
    </gene>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
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        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
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        <property type="protein sequence ID" value="CRL17748.1"/>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
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        <property type="entry name" value="P4HA-like"/>
    </dbReference>
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        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF246">
        <property type="entry name" value="TRANSMEMBRANE PROLYL 4-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
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    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="13"/>
            <end position="33"/>
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        <location>
            <begin position="164"/>
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        </location>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL17748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="303" mass="34685" checksum="932131040EA5EEF6" modified="2015-09-16" version="1">MASLPKFSTVFTWALYLIPVYIFILDPLVRGFFPGLLAPREDSVDLFDESDTPGPGINLTDDSFISPEDGVPFNCPSTEGYRVHLLSREPLIIYIENFISETEANHILDMSVNKYTPSIVYDGQTERVDPTKRLSDRALLDRDDTIRCLEDRARAFQGWRPDLYIERMWAQRYNASGHYRHHYDWAGSLARGGDRFSTFMVYLDADCEGGGTNFPRLRMPDGEGWCRFLECEQRDGVGKGKEGDMGITFKPIKGNAVFWENLRPDGTGYPETWHAAFPVTKGTKVGLNVWSWYQPKRRNRSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NUN5</accession>
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        </submittedName>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053732">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
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    <dbReference type="PANTHER" id="PTHR37171">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR37171:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE YRZF-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF03109">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="domain" description="ABC1 atypical kinase-like" evidence="2">
        <location>
            <begin position="57"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL17669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="229" mass="25953" checksum="155FC7274B8B9C2C" modified="2015-09-16" version="1">MLQIAISPVFHFGGKHITVTKDTLLNKRRPTVYRLELEEPRFGLPETVIVKQQKNEQEAEFCAEISAYKKLQKLHGTVIPTLFGEGSFNGRPALILSEIKGITLRDFAKLVETSVEENTLESCLGNAFQELYKYGAEHYDLNLGNFLVCDNGKVVVIDLEEVEFLDRQQSWERSVNLGSVGFLMSRFRDVRYPRRAPSPVLYWMPHTRDSDDRGGSEMPGSCCSMGPMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NV15</accession>
    <name>A0A0G4NV15_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcription factor, fungi</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S001g000779</name>
    </gene>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
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            <taxon>Penicillium</taxon>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4NV15"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="176"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL17819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="725" mass="81288" checksum="1F1D95D31B54DFDD" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NVN6</accession>
    <name>A0A0G4NVN6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial substrate carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S001g001090</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL18130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NVN6"/>
    <dbReference type="STRING" id="1429867.A0A0G4NVN6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="40"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="133"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="234"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL18130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="337" mass="37506" checksum="971B75B6D7EEA13D" modified="2015-09-16" version="1">MSYSSLCDDKRLLHLFGNPPHYGRLCDDFQIGYMPLDISQSITYPKWFGGSASCMAVLVSHPLDLIKVRMQMEHGGVKAGTLNTCIRIVRGEGVLALYNGLSAGFMRQLTYGSVRIGLYETLKEQTKANNIPTSPPVLGLLAGISGFIGAIFGNSSDIGNIRMQNDGSLPPHLRRNYRHIFDAWRQIKHQEGWKAFGQGLWPNAFRCGMMTSCQLASYDSFRDLIVATTGIHNDHPGLHLSASFLAALVATTLCSPIDVVKTQLMGSSSKQGILHVVKELTTAEGMRWVFRGWTPGFVRLGPQTMATLILLEQHKRLYRDFKEKTDTQKVLLPILRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NW10</accession>
    <name>A0A0G4NW10_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DDE superfamily endonuclease, CENP-B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S002g000122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NW10"/>
    <dbReference type="STRING" id="1429867.A0A0G4NW10"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041188">
        <property type="entry name" value="HTH_ABP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF73">
        <property type="entry name" value="PROTEIN PDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18107">
        <property type="entry name" value="HTH_ABP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="71"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL18252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="518" mass="59530" checksum="71873B6A1C78DA19" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NW57</accession>
    <name>A0A0G4NW57_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S002g000079</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NW57"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF97">
        <property type="entry name" value="ALLANTOATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="71"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL18209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="513" mass="57015" checksum="22479F139FEB8AA2" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWH8</accession>
    <name>A0A0G4NWH8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pentatricopeptide repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S002g000313</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWH8"/>
    <dbReference type="STRING" id="1429867.A0A0G4NWH8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="238"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="44"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="111"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="451"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="496"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="463"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL18443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="846" mass="96395" checksum="7FF937CD444D4268" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWL8</accession>
    <name>A0A0G4NWL8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AAR2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S002g000368</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAR2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWL8"/>
    <dbReference type="STRING" id="1429867.A0A0G4NWL8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13778">
        <property type="entry name" value="Aar2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13777">
        <property type="entry name" value="Aar2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.550">
        <property type="entry name" value="Aar2, C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007946">
        <property type="entry name" value="AAR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033648">
        <property type="entry name" value="AAR2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038514">
        <property type="entry name" value="AAR2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033647">
        <property type="entry name" value="Aar2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038516">
        <property type="entry name" value="AAR2_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689">
        <property type="entry name" value="A1 CISTRON SPLICING FACTOR AAR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689:SF4">
        <property type="entry name" value="PROTEIN AAR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05282">
        <property type="entry name" value="AAR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20981">
        <property type="entry name" value="AAR2_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAR2 N-terminal" evidence="4">
        <location>
            <begin position="7"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="AAR2 C-terminal" evidence="3">
        <location>
            <begin position="257"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL18498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="463" mass="51832" checksum="7A699AA7DBDD9B05" modified="2015-09-16" version="1">MSTHQPTPTILLPDLPPKTLVGIDLITFTSTPNFHGIRDLSPGWHFLYTGATETLSLRSGAWFYIGDITTAGKGSNDTALVTQGRNKNGTQNATVPEIYIWKWSANTESLVALDSESDSARQESMRYKANLGSVWQSGGLFKYRSRIAPSMLVKPESESGEKNEEDKPKPQIEARIQTEDDAQTEENGRRDWSGLTDRISPTLLSRVIGNPEVDVDGHPRWVLSSASTATRDADHIPGVDSPAEPEISEEAEREFGFIPVDLKRTWREGAVGRERTEAAKDRSWALGDLIDRYAGEASGGNQLLGELQFTFLMVLTMMNYSCLQQWKRLLELILTSRSAVLDREAFMSEVIRILSLQLQRCDDVDGGLFEIDGDEGGAFLRDLLMKLRQSVDDLVGDSASEVKLELDKLEEWVKAEYDWELRRGPVVRHGMLQLEDGEQVEMDWDGNDEDEETGEYAPVIVDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NX04</accession>
    <name>A0A0G4NX04_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cellulase</fullName>
            <ecNumber evidence="3">3.2.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Endo-beta-1,4-mannanase F</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S002g000522</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Has endoglucanase activity on substrates containing beta-1,4 glycosidic bonds, like in carboxymethylcellulose (CMC), hydroxyethylcellulose (HEC) and beta-glucan. Involved in the degradation of complex natural cellulosic substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3"/>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NX04"/>
    <dbReference type="STRING" id="1429867.A0A0G4NX04"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000078">
        <property type="entry name" value="Endo-beta-1,4-glucanase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142:SF1">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005194846" description="cellulase" evidence="11">
        <location>
            <begin position="19"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="12">
        <location>
            <begin position="463"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="386"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL18652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="500" mass="53038" checksum="80D990A8540E20C7" modified="2015-09-16" version="1">MKFTNIVLAASAATVACAYPQGRDVVPTKQSANIKKRANGFTWVGVSESGAEFGSNIPGTLDQDYAWPKTSQIQILRDAGMNVFRVPFLMERLVPTSITGTPDATYLAALKSTIKFITDSGAYAVLDPHNYGRYNGNIITSTSDFKAFWKTVATEFASDEKVIFDTNNEYHDLEQTLVLDLNQAAIDAIRAAGATSQYIFVEGNAYSGAWSWTTTNDNLKALTDPEDKIVYEMHQYLDGDSSGTSETCVSATIGKERLQSATTWLQDNNKKGFIGEFAGGVNADCEAAVEGMLSYMSENSDVWMGAEWWSAGPMWGSYMYSLEPSNGPAYSTYLPILEKYFVDGTASTPASSSSSSTKTAAKTSATTAAQTTAAQTTTTAAAIEVTSTPSSNVQVPSSVLESSSSTTSAPAETSAAVVPVVSTTAAAPTTLVTVTAPASSTSTSTSTAKSFTQVPTASPSSGSVAKHYYQCGGINWTGPTVCETGTTCVKQNPYYYQCVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXJ7</accession>
    <name>A0A0G4NXJ7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AMP-dependent synthetase/ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S002g000650</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NXJ7"/>
    <dbReference type="STRING" id="1429867.A0A0G4NXJ7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF3">
        <property type="entry name" value="SIDEROPHORE SYNTHETASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="522"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL18780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="987" mass="107345" checksum="95FA582A9998D78D" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXU2</accession>
    <name>A0A0G4NXU2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S002g000741</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NXU2"/>
    <dbReference type="STRING" id="1429867.A0A0G4NXU2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43111">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43111:SF1">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL18871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="470" mass="51229" checksum="F6A9D42E8E9B9F94" modified="2015-09-16" version="1">MAASLRAVREAVLDGRMHNIFNRRTQLEALQQTLLDKADAIQDAILAETSYVASEAAVEYLLTLNTLKEYHNTLNIDRALQDEYAIARGEDAASRRDPVGIVYIVPTSYTIFYSVLVAVAGALTAGNCIVIEVWHTLDSQKALPMLIKKLLESSLDRSTIAFVSTPATDEDLGPQHMRLHQDDHLPGKVVAVVDRTANINHAAEALVAARFSFGGRSPYAPDLVLVNEYIKEPFLMALVQASVSFLPSAGAIQGDEGRQGKEDQEQRGGLRIVSSLGRGKIVEADRLDPKALSDKPTDARLLVHTVRSLDHAIDLSNMVGNLRGAYVFAHEKSAKYLAQFINAEVSFVNHIPVEVLVGPPPPEQVALDRSMRYPTTVFSVPRPRYISPTLLSQLVTDILRLKSTSALRSTLVLQSSELVSPTQRPLGGGLGFFEQGILIGLGLFSVPMLAGVGALGYWTWTMVQKHGSGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYF4</accession>
    <name>A0A0G4NYF4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S002g000965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL19095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NYF4"/>
    <dbReference type="STRING" id="1429867.A0A0G4NYF4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL19095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="370" mass="42206" checksum="7365F6CF495DE919" modified="2015-09-16" version="1">MLVATKEILPSITTDFLLLEDIYCLSLCNRRLLALFRGQIKPQYYLERSAQLSFLRRLERDNPRYLACGTCLVLHSVDSISEPFELASPAHTYPPRVDCPVATFGKGLPSPFWMVRHKGFGTFSRYQLHFSHIHLAMRRFYCGPQYGISTDALSFTEVTSDFPCVDRVVSPITLFSIEAQICPTPPSLLLRIQDVMSMENTRLLLDDEDDFEPDQTYYGTLPACKHISKSFWMQNAPLNRYPTREYSTCDECNIDYETELSVNPSNGRIDAVMTSWINLGAGLNPDDPLWKINAGRMWGESDFWTEGLGYRHAGLSPRRTFEALTDTSLGDLTARNLSYLDDQRYETEMVPIPHSTPPTWALWNGAAIPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZ79</accession>
    <name>A0A0G4NZ79_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ras small GTPase, Ras type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S003g000166</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZ79"/>
    <dbReference type="STRING" id="1429867.A0A0G4NZ79"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000573">
        <property type="entry name" value="RHO family GTPase Rho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL19375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="197" mass="21883" checksum="46906B20A47404B7" modified="2015-09-16" version="1">MSQQQDDNVMRRKLVIIGDGACGKTSLLSVFTLGYFPTVPTVFENYVTDCRVDGRSVQLALWDTAGQEDYERLRPLAYSKAHVLLIGFAMDTPDSLENVKHKWIDEANERCPGVPILLVGLKKDLREDPLAIEEMRKKSLKFVTTKEGSDIATSIGARKYLECSSLTGEGVDDVFEAATRAALLTFDKRKSSCCVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZ85</accession>
    <name>A0A0G4NZ85_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S003g000110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZ85"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014:SF63">
        <property type="entry name" value="METALLOPEPTIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PEPTIDASE M20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="2">
        <location>
            <begin position="205"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL19319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="431" mass="46956" checksum="851E3057A8DDF48B" modified="2015-09-16" version="1">MQLKLSSSNRRRKIIKDFFPDPERHAVIYKDLHENPELPCQEQRTATVVADRLETLGFEVERGIGGHGVIGILRNGLGQNVLLRSELDALPLKENTGLPYASKVEQVDADGIKKGVMHACAHDMHMTCLLGVAALLHEARKFWSGTVIILFQPNEERLLGAKAMVDDGMFSKIPLPSVCLAQHCVPTKSGTIAVKPGRVLGYLDSLDVRVYGRGAHGATPQLGIDPIILAASILTRLQTIVGREMDPKEPVVIGCGTFHAGTDASIIPEYADFQVDVRTFSESTQQLAKSAVERVIRNECEVSGSPTAPRIVTTVSSPAIDNDDVATSRFTRVLESYYGSEPSKVIQVMPPDIVADDFVLLSLPPGGNPIPYVYWNIGVTDPETWEKASREGKLRDLPPTHSALYAPVIEPTLQTGIEALALSALTFLEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZC1</accession>
    <name>A0A0G4NZC1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beta-lactamase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S003g000211</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZC1"/>
    <dbReference type="STRING" id="1429867.A0A0G4NZC1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07730">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
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        <source>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Renault P."/>
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        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
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        <property type="entry name" value="CEBPZ/Mak21-like"/>
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        <property type="entry name" value="CCAAT-BINDING FACTOR-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048:SF0">
        <property type="entry name" value="CCAAT_ENHANCER-BINDING PROTEIN ZETA"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="235"/>
        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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        </location>
    </feature>
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        <location>
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        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
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            <end position="1061"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL19461.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1115" mass="123569" checksum="7E33ED01A397E168" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZI1</accession>
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        <submittedName>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX II-SPECIFIC SUBUNIT 65"/>
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    </dbReference>
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        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX II-SPECIFIC SUBUNIT 65"/>
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    </dbReference>
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            <begin position="403"/>
            <end position="567"/>
        </location>
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            <end position="485"/>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL19468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <sequence length="575" mass="63125" checksum="3CD55D733F0B38E5" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
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                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF7">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="611"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="878"/>
            <end position="898"/>
        </location>
    </feature>
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            <begin position="878"/>
            <end position="897"/>
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    </feature>
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        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL19539.1"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="925" mass="103173" checksum="3100B31BE92D47AF" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0U6</accession>
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    <organism evidence="3 4">
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
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                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
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                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF10">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="546"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="697"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="751"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL19903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="909" mass="99445" checksum="BFCBD179C51A7694" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0V3</accession>
    <name>A0A0G4P0V3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phox-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S003g000700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P0V3"/>
    <dbReference type="STRING" id="1429867.A0A0G4P0V3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06876">
        <property type="entry name" value="PX_MDM1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF3">
        <property type="entry name" value="SORTING NEXIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="6">
        <location>
            <begin position="99"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="4">
        <location>
            <begin position="414"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="5">
        <location>
            <begin position="861"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="569"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="683"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="622"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="644"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="687"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL19908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1221" mass="137122" checksum="8CAFEF64F708630C" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P164</accession>
    <name>A0A0G4P164_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major intrinsic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S003g000849</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL20056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P164"/>
    <dbReference type="STRING" id="1429867.A0A0G4P164"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF24">
        <property type="entry name" value="MIP AQUAPORIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="198"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL20056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="582" mass="64494" checksum="8E3ECDC173DA7735" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P1B2</accession>
    <name>A0A0G4P1B2_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin thioesterase OTU</fullName>
            <ecNumber evidence="11">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S004g000045</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="11"/>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P1B2"/>
    <dbReference type="STRING" id="1429867.A0A0G4P1B2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22745">
        <property type="entry name" value="OTU_OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17059">
        <property type="entry name" value="Ubl_OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.80:FF:000016">
        <property type="entry name" value="Putative ubiquitin thioesterase otu1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000096">
        <property type="entry name" value="Ubiquitin thioesterase OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048857">
        <property type="entry name" value="OTU1_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057766">
        <property type="entry name" value="Znf-C2H2_OTU1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312">
        <property type="entry name" value="HIV-INDUCED PROTEIN-7-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312:SF0">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21403">
        <property type="entry name" value="OTU1_UBXL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24560">
        <property type="entry name" value="zf-C2H2_OTU1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="OTU" evidence="13">
        <location>
            <begin position="133"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="79"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CRL20105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="336" mass="36586" checksum="2FDE354F62E6E5E7" modified="2015-09-16" version="1">MRIRLRGPSGQSTVTLDDTATIKDLQTQIAEKTGLATFDVKYGYPLKPLELDSFQLDQRILEVGINLNGESLIVAQKEGATRGVSDEAPTAPTAPSQPSQPSQPSQPSIPQRPQENTAEDPPEIASPDHAGTFVLRVMPDDNSCLFRAVGAAVMGDMDTMVELRSIIAGAIQSNPSEYTAAILGKKPDEYCTWIQNEDSWGGAIELKILSEYFNIEICSIDVQTLNMFQFNEGAPTRCIVVYSGIHYDVLALSPSRPPYTRANPLPHGDTKIFEAVDPVVLQKAKELCRVLQGKHYYTDTSGFTVRCNICGGTFTGERGATKHAAETGHYDFGEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P1F4</accession>
    <name>A0A0G4P1F4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxysterol-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S004g000048</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P1F4"/>
    <dbReference type="STRING" id="1429867.A0A0G4P1F4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000016">
        <property type="entry name" value="Oxysterol binding protein (Orp8), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF212">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL20108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="424" mass="47441" checksum="F900489E6BE12C02" modified="2015-09-16" version="1">MSATVVPEKAPDDSSKLKTFLSILRKFVGVADIASVRFSLPAQLLEPRPNLEYWHYLDRPETFASIGKSDDELGRMLEVLRFWFTKDLKYVKGKPCKPYNSTLGEFFRCSWDVNDNIPEEGNLPGIEASSNGSSTVTDGDEKVKVCYLTEQTSHHPPVSAFYIDCPERGVSARGFDQISAKFTGTSIRVSPGQHNLGIFVNIEKRDNEEYQLTHPNAHLGGILRGALSVTVADTCYVTCPKTGLKAILQYLEEGWIGRSQNKLEGVIFRYNQDKDTIVRLKDVPESDIVARITGSWHGKIYFTPAGTKEPRLLIDITPLHPVTKDLPPSEEQLSNESLKFWSGVTDAIVEKQFNQATKLKQDIEERQRQRAAERIEKGTEWSPRFFTGAVTPLGKPELTEEGQKVLEGIRTGEFALTESTVQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P1U2</accession>
    <name>A0A0G4P1U2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S004g000241</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P1U2"/>
    <dbReference type="STRING" id="1429867.A0A0G4P1U2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005996">
        <property type="term" value="P:monosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000418">
        <property type="entry name" value="UDP-glucose 4-epimerase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725:SF3">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="2">
        <location>
            <begin position="57"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL20301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="436" mass="47600" checksum="5AE9377DDF2A8241" modified="2015-09-16" version="1">MIEPTSFSSSRSDSPQRSDASSPVQSPIALDTPATEAGDPFDNLHDLLRRIPLQSHILVTGGLGFIGSHTTLELLKANYNVIVIDNLSNAFENVFGRISLLAKKHHEENGTKMPSLRLHAHDYRDTKALQPLLEEYQLPSRWGTPKSGIAGVIHFAAYKAVEESIRKPLKYYSNNVSGLVDFATTLGDFGIKTFIFSSSATVYGTLATSGVPLKEELCVHKEELYTDHEGSQQSIQPGCTGITNPYGRTKWMCETILADLAASDPEWTIVALRYFNPVGCDSSGLLGEDPRQAPTNLLPVVVKVMTGQYSELAMFGTDWETEDGTAVRDFIHVSDLARGHIAALSSANEGKLTENFRTFNLGTGKGNSVMDVVSTMESVIEKPIPRRAAPRREGDVGACVAVVDRSTEELQWKTEKSLKDACQDICNFLDVSGLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P230</accession>
    <name>A0A0G4P230_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">U4/U6 snRNA-associated-splicing factor PRP24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S004g000312</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a recycling factor of the spliceosome, a machinery that forms on each precursor-messenger RNA (pre-mRNA) and catalyzes the removal of introns. Chaperones the re-annealing of U4 and U6 snRNAs (small nuclear RNAs) released from previous rounds of splicing, an initial step in reforming the U4/U6-U5 tri-snRNP (small nuclear ribonucleoprotein) that can reassemble into another spliceosome complex; this step involves binding U6 and facilitating the unwinding of the U6 internal stem loop, followed by base-pairing of U6 to U4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P230"/>
    <dbReference type="STRING" id="1429867.A0A0G4P230"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="HAT"/>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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        <property type="entry name" value="RRM_occluded"/>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="TPR-like"/>
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        <property type="match status" value="4"/>
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        <location>
            <begin position="822"/>
            <end position="899"/>
        </location>
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    <feature type="domain" description="RRM" evidence="11">
        <location>
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        </location>
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    <feature type="domain" description="RRM" evidence="11">
        <location>
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            <end position="1067"/>
        </location>
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    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="1102"/>
            <end position="1175"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="755"/>
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    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1184"/>
            <end position="1271"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="10">
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            <begin position="114"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="757"/>
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    </feature>
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        <location>
            <begin position="784"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1228"/>
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            <begin position="1242"/>
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            <dbReference type="PROSITE" id="PS50102"/>
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        <source>
            <dbReference type="EMBL" id="CRL20372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1271" mass="143449" checksum="BF29E638A11ADF96" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2H2</accession>
    <name>A0A0G4P2H2_PENC3</name>
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        <submittedName>
            <fullName evidence="4">SAC3/GANP/Nin1/mts3/eIF-3 p25</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">PCAMFM013_S004g000456</name>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the proteasome subunit S14 family.</text>
    </comment>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
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        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSN8/PSMD8/EIF3K" evidence="3">
        <location>
            <begin position="109"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL20515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="281" mass="31248" checksum="1CBFCE712FB938EC" modified="2015-09-16" version="1">MSDLQSLVSELHGAIERKQFDAANDLLSRSKRALLLQNALIPTSSTPPQLVVLARQVLELGALASIRQTYAQLFTRYYQQLQPFYDLERHAGLPGQSSSEVDFSTSQRSKITGLYLLLLLSMGDSANFHTVLEGLVEEASLKGGRVEDDACIKYPVELERNLMEGSYDKVWRETKSERVPSEDFGLFSNVLIGTIRNEIAGCSEKAYPSLPISNAKNLLFLESEGAVIEFAKQRGWILRDGRIYFPVEPEATARSEKDILVASGTVIENALGYARELETIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2K3</accession>
    <name>A0A0G4P2K3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S004g000480</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the polysaccharide monooxygenase AA14 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4P2K3"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054497">
        <property type="entry name" value="LPMO_AA14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22810">
        <property type="entry name" value="LPMO_AA14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012904244" evidence="12">
        <location>
            <begin position="16"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL20539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="263" mass="28535" checksum="C9090AB8CD28975A" modified="2015-09-16" version="1">MLPIAILALVAAAQAHTVAWTKGMYCSGGPDLSTVNLNTNTAVWPLWNLTKQEWWFQHERGCDTAPPMDGEILELPAGGRFTVELAHNRAQTTLSYDGQYASVWPDGKDHPEDWAGPGSPPECIQDDGAMHTNNQSMAAGTAFAISYHSDLAEVTIENLAVFTVLEHTPWKRIATYEVPADLPPCPPGGCTCAWLWCNVTGSTSSKKVAPAQVAAYCEGDSTECVKGAKQMIAFNQKTGNNVQVPSGKTPMYNTAWGWKSEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3C7</accession>
    <name>A0A0G4P3C7_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">60S ribosomal export protein NMD3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S004g000756</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NMD3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P3C7"/>
    <dbReference type="STRING" id="1429867.A0A0G4P3C7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048899">
        <property type="entry name" value="NMD_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048898">
        <property type="entry name" value="OB_NMD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21193">
        <property type="entry name" value="NMD_SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21192">
        <property type="entry name" value="OB_NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nmd3 N-terminal" evidence="9">
        <location>
            <begin position="23"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 SH3" evidence="11">
        <location>
            <begin position="256"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 OB-fold" evidence="10">
        <location>
            <begin position="320"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="490"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="492"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL20814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="527" mass="60110" checksum="15DB3FB0811008F2" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3J4</accession>
    <name>A0A0G4P3J4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipase, GDSL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S005g000065</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL20901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P3J4"/>
    <dbReference type="STRING" id="1429867.A0A0G4P3J4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01833">
        <property type="entry name" value="XynB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051532">
        <property type="entry name" value="Ester_Hydrolysis_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383:SF31">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383">
        <property type="entry name" value="THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195135" evidence="2">
        <location>
            <begin position="24"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="3">
        <location>
            <begin position="59"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL20901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="323" mass="36172" checksum="ACDA26FCDC4C9143" modified="2015-09-16" version="1">MRQSTPILWVVQACLIWLTLVSASPAVSRDNLVSSDSDSDVPALQTRDTKPFPLRILPLGASITRGYKSKDGNGYRKWLRQQLRYAGWDVDMIGTMKSGTMRDNDHDGHIGWRIDQIAAHAKEIIPQQPNLILLNAGTNDAIQDYKVDTAGKRMDSLLTYLFDNIPNTTIILSTLTFNGKKPQLGTDISTQYIEIAAKRRARNESLVLADMSTFIQWKQLVDKIHPTALGYEEMASVWWAAIQQAEKEGLLKAPTSTAKNNTAFSKVREKELDDSTADPSLPAYTAPPQPTLKSNNGSSLFHQWHLWAVTFQMIMMCIGFSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3P7</accession>
    <name>A0A0G4P3P7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S005g000130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL20966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P3P7"/>
    <dbReference type="STRING" id="1429867.A0A0G4P3P7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021514">
        <property type="entry name" value="DUF3176"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394:SF5">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11374">
        <property type="entry name" value="DUF3176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL20966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="569" mass="62875" checksum="262474300AED0D0B" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P468</accession>
    <name>A0A0G4P468_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thiopurine S-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S005g000232</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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        </citation>
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</entry>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
    <dbReference type="EMBL" id="HG793139">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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        </location>
    </feature>
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            <end position="197"/>
        </location>
    </feature>
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        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL21494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
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</entry>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793139">
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PA-PLA1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509:SF6">
        <property type="entry name" value="PHOSPHOLIPASE C1020.13C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
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            <end position="948"/>
        </location>
    </feature>
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        </location>
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            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
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            <end position="100"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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            <end position="434"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL21548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="972" mass="107546" checksum="272FE96AA2D49811" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5W5</accession>
    <name>A0A0G4P5W5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Pectinesterase</fullName>
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        </recommendedName>
    </protein>
    <gene>
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    </gene>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
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                <person name="Sallet E."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in maceration and soft-rotting of plant tissue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1-&gt;4)-alpha-D-galacturonosyl](n) + n methanol + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22380"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14573"/>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
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            <dbReference type="EC" id="3.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
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    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pectinesterase family.</text>
    </comment>
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        <property type="protein sequence ID" value="CRL21706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4P5W5"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
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        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
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        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
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        <property type="entry name" value="Pectinesterase_Asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321">
        <property type="entry name" value="ACYL-COA THIOESTER HYDROLASE YBHC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321:SF57">
        <property type="entry name" value="PECTINESTERASE 53-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00503">
        <property type="entry name" value="PECTINESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="9 12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005118194" description="Pectinesterase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="13">
        <location>
            <begin position="43"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CRL21706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="319" mass="33572" checksum="358488D5D454DC87" modified="2015-09-16" version="1">MHPHNFLLAALSLGAAVLAAPTELVARTARTSAPAGCLTVGSRGKYSTIGAALTALGSSKAPACIYVASGTYKEQLTINYGGALTLYGQTVDADTYKENTVTITHTISSPVAGSLDKSATVNVVASGFKMHNINVVNGFGKSAQAVALVANADKLGFYACQFLGYQDTLYVKSGTQYYSNSKIEGAVDYIFGAASAWFNNCDIVSNGPGAITASSREKATDKTWYAFDHCNIKGSVADGSVFLGRPWRGLARVIYQNSNLGRVVNAKGWTPMAQGATPLYYEYKNNGAGSSTSARQFLSHISGAVTKETVLGSDYATWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6T8</accession>
    <name>A0A0G4P6T8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S007g000031</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4P6T8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030705">
        <property type="term" value="P:cytoskeleton-dependent intracellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22211">
        <property type="entry name" value="HkD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043936">
        <property type="entry name" value="HOOK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947:SF28">
        <property type="entry name" value="GIRDIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947">
        <property type="entry name" value="HOOK PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19047">
        <property type="entry name" value="HOOK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HOOK N-terminal" evidence="6">
        <location>
            <begin position="8"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="741"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="186"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="263"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="514"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="671"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL22050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="761" mass="87130" checksum="CD1B0651B0711653" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7M1</accession>
    <name>A0A0G4P7M1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase superfamily, zinc-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S007g000278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4P7M1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF1">
        <property type="entry name" value="TRANS-ENOYL REDUCTASE STHE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL22297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="136" mass="14618" checksum="60E33F093FB9388B" modified="2015-09-16" version="1">MAHGSHREDSPCGHQPDEMSLNDAASIGLGLFTAGLGLFPELKVPGSLYDPNYLEIAEDKRVALVADGSTATGTRAIQLLKLAGLRPIPTCFKTNMDLVRRFGAENAFDYSDPECAVEIRRYTGGTLAYALDVGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P8E3</accession>
    <name>A0A0G4P8E3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcription factor IIS, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S008g000027</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post-recruitment and recruitment steps of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IWS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P8E3"/>
    <dbReference type="STRING" id="1429867.A0A0G4P8E3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.10:FF:000003">
        <property type="entry name" value="Putative Transcription factor IWS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051037">
        <property type="entry name" value="RNAPII_TF_IWS1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="8">
        <location>
            <begin position="267"/>
            <end position="344"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL22598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="443" mass="50703" checksum="F3D37FB27620FC8A" modified="2015-09-16" version="1">MSASPDHKAVSPAASPEPEVPERVATPVAGDDNEGENLTDPTAEAKELTEDVDDELHAADDDEEDDDDKLSDDESILSEVDEAQFDNFDPENVDVEDRPQLAIDEDNLKLIGRHKRKRTEDGESRPRRKEGRREKKSRRADEGGDEGGSSRRRERKQREDKPEVDEETLDPETRRRRALDRAMDEAMKKPAKRRFRKQDGIDLESMADAEIEDMRKRMTHAAQMDAINRQEGKPAMHKLKLLPEVIMLLNRNQYTSALVDPEINLLEAVRFFLEPLDDGAMPAYNIQRDLLTAITKLPINKDALIASGIGKVVVFYTKSKRTERRIKEMAEKLLAEWTRPILQRSDDYSKRVYQEADYDPTKVVRRAAPTPEEIQAEARAREMLPPRLLNRARVDRTNVSYTVVPRQTAVRETQFARPLGSSGEDRFRKMQARQAAARKASRR</sequence>
</entry>
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    <accession>A0A0G4P929</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CRL22815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="135" mass="15548" checksum="AA33AE024A81E7EB" modified="2015-09-16" version="1">MSHLQYFSYKGVGERNRQKFKYSQAVRIGDRIECAGQGGWNRETGEFYREINEQIDQAFANVEHNLKDAGGEGWNQVFRVNSYHVPINDEALAAMVRNFEKYMPGHQPIWTCVGVTRLGEDDMRVEIEVVAHVPN</sequence>
</entry>
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            <taxon>Eurotiomycetidae</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CRL22847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="33" mass="3833" checksum="6BEFBC784AD9C183" modified="2015-09-16" version="1">MHPGRIMAVEQSTHFIRLVSRLNTRAWSNPGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
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    <name>A0A0G4PAB1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger, LIM-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S009g000193</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PAB1"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000119">
        <property type="entry name" value="LIM domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000105">
        <property type="entry name" value="Similar to LIM domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205">
        <property type="entry name" value="FOUR AND A HALF LIM DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205:SF16">
        <property type="entry name" value="GH01042P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="487"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="42"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="256"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="339"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="616"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="344"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="422"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="618"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="647"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL23253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="691" mass="74042" checksum="EEB8B20047C8EE66" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAC5</accession>
    <name>A0A0G4PAC5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flavoprotein WrbA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S009g000169</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WrbA family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PAC5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PAC5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000001">
        <property type="entry name" value="NAD(P)H dehydrogenase (Quinone) FQR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010089">
        <property type="entry name" value="Flavoprotein_WrbA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01755">
        <property type="entry name" value="flav_wrbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002999">
        <property type="entry name" value="PRK03767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546">
        <property type="entry name" value="FLAVODOXIN-RELATED PROTEIN WRBA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546:SF23">
        <property type="entry name" value="FLAVOPROTEIN-LIKE PROTEIN YCP4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="2">
        <location>
            <begin position="5"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL23229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="201" mass="21233" checksum="25EB6C33440565DA" modified="2015-09-16" version="1">MAPKIAIVYYSTYGHIKALAEAEKKGIESAGGQAEIFQIAETLSDEILAKMHAPAKASYPIAEPADLLAFDAVLFGIPTRYGNFPAQWKTFWDKTGGIWGSGGYWGKYAGLFVSTGTQGGGQESTALASMSTLAHHGFIYVPLGYKTVFAQLSNLDEVHGGSAWGAGTFAGADGSRQPSALELEVATAQGKAFYEAVARVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAS3</accession>
    <name>A0A0G4PAS3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase, family 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S009g000358</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PAS3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PAS3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050295">
        <property type="term" value="F:steryl-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904462">
        <property type="term" value="P:ergosteryl 3-beta-D-glucoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000131">
        <property type="entry name" value="Glycoside hydrolase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000106">
        <property type="entry name" value="Glycosyl hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041036">
        <property type="entry name" value="GH5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052066">
        <property type="entry name" value="Glycosphingolipid_Hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308:SF5">
        <property type="entry name" value="ERGOSTERYL-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18564">
        <property type="entry name" value="Glyco_hydro_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="5">
        <location>
            <begin position="69"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5 C-terminal" evidence="6">
        <location>
            <begin position="633"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="570"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="572"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="603"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL23418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="761" mass="87548" checksum="B54753905EAC26FD" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBE8</accession>
    <name>A0A0G4PBE8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S010g000053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PBE8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL23615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="83" mass="8994" checksum="FBD88E2B91867650" modified="2015-09-16" version="1">MPVPTADLFDKQQNETNCTQPPSSATHTSPDHINNNSYFGTAPGSSASASQNADSGRALTKEEADRLYEERMEEEYAKRDGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBP8</accession>
    <name>A0A0G4PBP8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Survival protein SurE-like phosphatase/nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S010g000184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PBP8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PBP8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="entry name" value="Survival protein SurE-like phosphatase/nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027746">
        <property type="entry name" value="TTL"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00087">
        <property type="entry name" value="surE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551:SF1">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SurE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Survival protein SurE-like phosphatase/nucleotidase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL23746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="318" mass="34471" checksum="6E9C290137E78883" modified="2015-09-16" version="1">MHILVVNDDGPPSTKLSPYLRPLVEALKANGHQVSVAIPAASRSWIGKAHLIEASLTASYVHPDAFNADGSWDETFESPDPENDWVVIRNGTPASCTQLGLYNLFTERAPIDLVISGPNHGRNASTIYNLSSGTVGGALEAVFCSKRGIAISFGSKDPQPDEIISAAARLAVRVVRYLYENWDERVELYNINVPMVLDVEERPVLYTRTLPYYWSRGCLYAEEGTGKKVNGVNGVNGVNGVHVNGETNGTAVNGHAPASSRQRQFKWSADLSDMKKTLQESEVGTDAHTVLNGSTSVTALRANFWHVPGLEGPLDIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBS4</accession>
    <name>A0A0G4PBS4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S010g000157</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PBS4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PBS4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF150">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="475"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="509"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="534"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="107"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="585"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="585"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL23719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="618" mass="67179" checksum="1B021704BB773F0B" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PD04</accession>
    <name>A0A0G4PD04_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proteinase inhibitor, propeptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S011g000166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I9 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PD04"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.80:FF:000005">
        <property type="entry name" value="Proteinase inhibitor I2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052471">
        <property type="entry name" value="PBI_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28288">
        <property type="entry name" value="PROTEASE B INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28288:SF2">
        <property type="entry name" value="PROTEASE B INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL24172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="70" mass="7918" checksum="5BCD91F05AA61565" modified="2015-09-16" version="1">MPLYNITLKTDAPVEELEKAKETAREKGGVIKHEYSIIKGFTVEFPEDNVQTFESTQHVHVERDGGVTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PD27</accession>
    <name>A0A0G4PD27_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S011g000219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PD27"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL24225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="73" mass="7891" checksum="1FAB88AB4CF8D6A2" modified="2015-09-16" version="1">MCDLLLFVPKEVRLAGKIVIVGLGNKALGHETASLIITIGDKAMYKAPSLIFEPTLKSTQIPRTKLVQMPSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PEK3</accession>
    <name>A0A0G4PEK3_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Magnesium transporter NIPA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S013g000005</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL25130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="315" mass="34076" checksum="D69A2058CDDF9976" modified="2015-09-16" version="1">MSSQANWNSVTGIATLLFDGNLVAIAIAVLVTFGVPIALHIFFFQAVASPPSSNFLLLGPSGAGKTAFTTLLEAKSSLASNKSHSTHTSQQSTLVTVTLPPTVPTGSNRYRSVNDPSLKEATRNPIRYRVRDTPGHGKLRASQGIAELQAMSQSKDIKTRLRGVVFMVDTAALVDEATLRDTATYLHDVLLFLQKRAKNGSSSKRTTDIPVLVAANKQDLFTALPPGAVREKLEAEIDRIRKSKTKGLLDASADTELEGEEEILGNDEQEAFSFKLLEHEVGVKVDVVGGAVKGDLQEEFGSGVRRWEEWIGMCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PFW4</accession>
    <name>A0A0G4PFW4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S014g000092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PFW4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PFW4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053144">
        <property type="entry name" value="Acetyltransferase_Butenolide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43233">
        <property type="entry name" value="FAMILY N-ACETYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43233:SF1">
        <property type="entry name" value="FAMILY N-ACETYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL25196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="193" mass="21831" checksum="F3D80C0398A65B36" modified="2015-09-16" version="1">MSSPTSEIRNQPKTWTKGEYLVSTDTSLIPIQTLNTWYAGKEFYWAKPMPEPALRETIQNSLCFGLYHNPSQSDKSPENDTSNSTLEFVGFARCVTDYTTFLFLTDVFVLSSIQGLGLGTWLVTCVQEIIETMPYLRRSLLLTGDWKRSVPFYEKVMDMELMVCNPPVDGKDAVGFAVMQRKSWGAPGFGERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PG40</accession>
    <name>A0A0G4PG40_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S014g000172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PG40"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL25276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="233" mass="26712" checksum="8BB794753FB5A9BA" modified="2015-09-16" version="1">MCIHWTCKYTLCGCIWDMDPSKCPDKHLCWGPRMITLESHTATCADCWARGDRRVYEPQTYDEANREGEASKTVTLDCESDADASDNSSNDDEDYFSAEEFLSPSPYPRPATPQLYYEVHSELCPVSEDNEFDLTRTCDPVDLALMGRDYRARRHKTTSSQYSSDSTDSFVSCEEYLDEETPDEEDFDSGNEEDDVYYSIVGPTVRPKGLIKSLEDRSLRLYGSVQEYYPTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGJ3</accession>
    <name>A0A0G4PGJ3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S014g000246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PGJ3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195668" evidence="1">
        <location>
            <begin position="23"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL25350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="99" mass="11266" checksum="B2FCCF813754DF57" modified="2015-09-16" version="1">MCAGALLAYRELYLTFLRMVAAFEIVTDTSIETHPVKGVADLTNLVSMPREYEVRFVPRNQSALQSVLEAKNTYVLDFLCHFLAFHFRLSAQSLPLFAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGR3</accession>
    <name>A0A0G4PGR3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Siderophore transporter, RhtX/FptX family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S015g000130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793148">
        <property type="protein sequence ID" value="CRL25544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PGR3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PGR3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17325">
        <property type="entry name" value="MFS_MdtG_SLC18_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF29">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G10530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="27"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL25544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="490" mass="52928" checksum="7899B1E0A4ED3D05" modified="2015-09-16" version="1">MTWSKPFLKLRDQRPWLLPLRSSQSFIVTTISLSMFTDLFLYAMIVPVMPQALVSRAGVAFEDREYWNSVLLISEAVSALTCCPIFGYMLDISGTRQGPYLSGLVLLFASMVILTASHSVTWYIVARVLQGAATAMVSVAGLSIVTDAVDRASLGQMIGYLGTAMTLGFMSGPLLGGLVYQVGGFYAVFGMAFGIIALDFFLRLAVVEKRIAERWLCLTDGERPSQENGYIPEQPPYGALETITGSSQTVTEISKSTFALGKLLKQPRILISLWAGIVAALVVSAFDATLPVFVENTFHWNVLGAGLIFLPGAAAAVFQPFFGFLSDRLGTRVITFASFVILTPSLICLRFVEENSPSHIGLLCVILGLVGMCIDLSEPALIVEMQRVLDDMEAGDPGVFGGRGAVAQAFSLENMAHFGGLALGPMVGGFVEFRYGWKIMTLGLGIVSAVTAMPMLWLSGPMEAVSWTESADEEMEREPLLTDQHASGCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGX5</accession>
    <name>A0A0G4PGX5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Membrane insertion protein, OxaA/YidC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S015g000071</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793148">
        <property type="protein sequence ID" value="CRL25485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PGX5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PGX5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20069">
        <property type="entry name" value="5TM_Oxa1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="YidC/Oxa/ALB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF66">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEIN OXA1L"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 9 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Membrane insertase YidC/Oxa/ALB C-terminal" evidence="13">
        <location>
            <begin position="139"/>
            <end position="333"/>
        </location>
    </feature>
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        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="416"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="357"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="416"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="439"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="492"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009877"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02096"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL25485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="501" mass="55300" checksum="98F15978D603254C" modified="2015-09-16" version="1">MMGHVGLKGSGAAATLASQRMTAMSRSSRSMSTLRSQSLRFPSQRGQLKSALSGSAPWRMTPAAIGPAAVRFNSTSSDSTLPEFAFDGTLKNAVNIHDITTIPERIGYLKELGLDFGWGFSSTMQWLIEHTHIWTGMPWWASIVAVGLITRVAMLKPVIGASENAARMTNAKSKTDPLRQKMVAASTEGNQQEAQIVRAQLKEINDAHGIKTWKSILPMLQIPLGFGCFRVVRAMTSLPVPALATETAGWVKDLTVADPTYILPMIAAGTLCLSLRRGGESGQMPMMQTEAGKYIIYGFPVMSFAFMAFMPSALQFYFVATGLFGLGQTYLINSNVFRTWMSLSIAQKPTNGPKYSAVTQSTESKGLRQLLERLEKEKAAQEKARTAIPVSPAQEDVKISFIDRIYQKFGKAGSSLSKSVSETMGTGTVEQRIAKDHKKRADEYEQQRKDEDELMRRERNEARRKEHMQTLENERTKASKSLKNSQAAARKPNGRRGSRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PH06</accession>
    <name>A0A0G4PH06_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="17">SNF2-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PCAMFM013_S015g000245</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793148">
        <property type="protein sequence ID" value="CRL25659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chromatin structure-remodeling complex subunit snf21"/>
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    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000008">
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    </dbReference>
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        <property type="entry name" value="Chromatin structure-remodeling complex subunit snf21"/>
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    </dbReference>
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        <property type="entry name" value="Putative chromatin structure-remodeling complex subunit snf21"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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    </dbReference>
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        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Bromodomain"/>
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        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029295">
        <property type="entry name" value="SnAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
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        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00573">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00951">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01314">
        <property type="entry name" value="SnAC"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PHD3</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
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        <subcellularLocation>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Mitochondrial 54S ribosomal protein YmL19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
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    </dbReference>
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        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="12"/>
            <end position="70"/>
        </location>
    </feature>
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    </feature>
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        <source>
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        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00298"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="153" mass="16519" checksum="DFCD2E62C452B3D7" modified="2015-09-16" version="1">MARNVLAKDQFVKLIVGAGQASPSPPVGPALGSKGVKSMDFCKEFNARTAHINTGVPIPARVTVRPDRSFSFELRTPTTTYLLLNAANVEPRKNRLRGAMNPGHDVCGKISLKHVYEIAKLKHTETRLSGLSLEGLCKSVMSQAKSIGIQVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PI77</accession>
    <name>A0A0G4PI77_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger, C3HC4 RING-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S017g000108</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793150">
        <property type="protein sequence ID" value="CRL26125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PI77"/>
    <dbReference type="STRING" id="1429867.A0A0G4PI77"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047134">
        <property type="entry name" value="RNF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23041:SF78">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23041">
        <property type="entry name" value="RING FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="121"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL26125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="205" mass="22036" checksum="C4F1EEB6816B3271" modified="2015-09-16" version="1">MSRNRADVVDLTTRSSRQNPISLSSSPPTASDHASSSRHAQLPASRGVKRRRHWSDEHGDSVASSSSTLSEAEPIETIDMTDDSAAASLARTVAKQREDAIKAQASEESNSNLSAILAYKCPICMETPVDATSTSCGHLFCHKCIIDCLKMSEQTRGGDSSKQHKGTCPVCRTPISRKETPGKAKNLIPLLFLTKKRGDLPVSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PIZ7</accession>
    <name>A0A0G4PIZ7_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S017g000146</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="HG793150">
        <property type="protein sequence ID" value="CRL26163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PIZ7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PIZ7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000611">
        <property type="entry name" value="CMGC family protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000144">
        <property type="entry name" value="Cyclin-dependent kinase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF46">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="8"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CRL26163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="309" mass="34907" checksum="A31C18226F34D6F4" modified="2015-09-16" version="1">MSEGLNSYQKLEKLGEGAYATVFKGRNNTTNELVALKEIHLDVEEGTPSTTIREISLMKRLKHENILALYDVIQMDQKIVLVSEYMDSDLRRFMNVRGGALDLPTVKLFAQDMLQGIAYCHEQSVLHRDLKPQNLLIGWDGRLKLGDFGLARDFSVPVGNLSNDVVTLWYRPPEVLLGSCTYGTSLDIWSAGCIIAEMYTGHALFPGNSDGNQLLRIFQAMGTPSECTWPGVSQLPEFNPWFPIYSPLDMEQLISGMGYFGINLLERMLRMQPELRLSAADALLHPWFQNFFSRAVPSNPPTQRVYRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PK59</accession>
    <name>A0A0G4PK59_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Berberine/berberine-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S019g000224</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PK59"/>
    <dbReference type="STRING" id="1429867.A0A0G4PK59"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195751" evidence="3">
        <location>
            <begin position="19"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="122"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL26807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="591" mass="65017" checksum="0A39F30969B48D2B" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKQ4</accession>
    <name>A0A0G4PKQ4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">threonine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S019g000180</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKQ4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PKQ4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000023">
        <property type="entry name" value="Threonyl-tRNA synthetase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000039">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF50">
        <property type="entry name" value="THREONINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="76"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CRL26763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="515" mass="57727" checksum="BC2028D21AB724FA" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKV4</accession>
    <name>A0A0G4PKV4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 8">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="1 8">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 8">Lysyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S020g000138</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>tRNA(Lys) + L-lysine + ATP = L-lysyl-tRNA(Lys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="1 8"/>
    <dbReference type="EMBL" id="HG793153">
        <property type="protein sequence ID" value="CRL26979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKV4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PKV4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070154">
        <property type="term" value="P:mitochondrial lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000094">
        <property type="entry name" value="Lysine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00499">
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    </evidence>
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    </evidence>
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        <source>
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        <source>
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        <source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00048573"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL26979.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="556" mass="62390" checksum="2ACDB8D13C3AEAFB" modified="2015-09-16" version="1"> </sequence>
</entry>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        </subcellularLocation>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF02096"/>
        </source>
    </evidence>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Dupont J."/>
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                <person name="Debuchy R."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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    </feature>
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            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="CRL27362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="210" mass="23448" checksum="42B2A216C183774E" modified="2015-09-16" version="1">MQATCSDRSPLECSHFLNQDPPLQCRRQNAKGAADPDRQSSKINKRSSAGKRYSKNSAGRSNKGPRRRNSVSFPTVRAQFSALPVEDRLQFLSWLFEGALSHCIPTPLITDATVSRCISSQDSDVAYDCDQPGSNTELVDAQHTPCTRKGLRWSVEGDSLLVKLREEQNLAWSEVTKLFAQKFPGRSKGSIQVYWSTTLKKQRRSLADAT</sequence>
</entry>
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    <accession>A0A0G4PMK8</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL27378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="52" mass="5658" checksum="FC0C20581E749C46" modified="2015-09-16" version="1">MSGIRKVSSAHRRQSFRARSQRVLSLSSSESDGTHSPSRSVVGDTFEDGSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PP04</accession>
    <name>A0A0G4PP04_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aromatic-ring hydroxylase-like</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
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        <lineage>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
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                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
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        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HG793158">
        <property type="protein sequence ID" value="CRL28120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF1">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="18"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL28120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="401" mass="44431" checksum="D505607FBD07537D" modified="2015-09-16" version="1">MLPTQIIRLESRSDKVYIGAGIAGLTLAQALRRHGVPCTVFERDESAEVRNQGWGVSIHSTLTTWEAHILPEIYDGVCEAQVNPAIGRDEVRGVPWINGATGKVEQSVPKCKRLRLRRDGIRKALMEDLDIKWGKRLVNILKVDGGVRAEFTDGSTVLGDALVGADGSTSIVRKFLAPTTHELHRLPINAVGCALTMSEEQVNYFKDHVDPLYFMGTHPETDTFVFWSLLDTPTAPGQPYRAQVYFSWVASDADEELLKQPLLDVFKQKGRPFFPRMGDMVEALPEDTVVTKVNLVDWPSVEWDNWNGTCTLIGDAAHCMVIYRGEGVNHAIVDACQLADAIKSATDGHMSFSDAIRAYEKQMRPRAKEAVETSRQAGHDGHCYAKVDKEGSFALLGEKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PP16</accession>
    <name>A0A0G4PP16_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase, AAA+ type, core</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S026g000062</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793159">
        <property type="protein sequence ID" value="CRL28197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PP16"/>
    <dbReference type="STRING" id="1429867.A0A0G4PP16"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF21">
        <property type="entry name" value="ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="586"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="670"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1094"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL28197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1178" mass="131124" checksum="9989820A3CD391B3" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PP70</accession>
    <name>A0A0G4PP70_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S026g000044</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793159">
        <property type="protein sequence ID" value="CRL28179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PP70"/>
    <dbReference type="STRING" id="1429867.A0A0G4PP70"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL28179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="344" mass="39663" checksum="D3531741B0608DE6" modified="2015-09-16" version="1">MPSLMDLPLEIRAIIFKEVINGHRTPPISPSKLNMVHLLDMEYKANISRFQPYYEQRDTHSPSNSLSLLLTSRQVSTETQWILNRTNNNYVLDISVLNDLDLFATWVSVPQLTTRLSTLHVDIRLFGHMITSKEGRNQIGCGGRLGFHWSFYAILERFLRYGPVGVKKEHTNDWGDPCSYGNRKICVENLILDFHSAETELPYPPDNLEYGAWMDKHGGGSQPINEQEEEAESLAYKTRPEWLLCYLENCLEFIIDMSYHAAEYGGFIYKRIGTISMLVDGRLKATIDLAGILARLTFSSPADTMGHLQSEIRLSKFWKWKKATLWRREALGFPVVWPQDMERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPN3</accession>
    <name>A0A0G4PPN3_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dihydrolipoyllysine-residue succinyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">2-oxoglutarate dehydrogenase complex component E2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S026g000058</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.61" evidence="4"/>
    <dbReference type="EMBL" id="HG793159">
        <property type="protein sequence ID" value="CRL28193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PPN3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PPN3"/>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050537">
        <property type="entry name" value="2-oxoacid_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006255">
        <property type="entry name" value="SucB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004309">
        <property type="entry name" value="PRK05704.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01347">
        <property type="entry name" value="sucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416:SF5">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="12">
        <location>
            <begin position="61"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="137"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL28193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="456" mass="49881" checksum="90B6701652A0CFAE" modified="2015-09-16" version="1">MALRWTSRAAFRLPARLRRVPGHVALPAISSAFAKSGNSQVRHSPLQVRTFSGSLCKNDGKIVVRVPQMAESITEGTLNQFAKKVGDFIEADEELATIETDKIDVSVNAPRAGIIQQLFVAEGDVVNVDQEIAEIQAGEKQSASQNKKEISKASEKIADVSPKSQDETASYNSTPTLDNATPETPAPKPDVAPRAEPIQKAEKPPANPSSAAQSHTSWGFKPSRAEEKVKMTRIRKRTAQRLKESQNTAAFLTTFNEVDMSRLIELRKNNKETVMEKHGVKLGFMGFMARASALALKEIPAVNASIENDDTIVYRDYVDLSIAASIPKGLVTPVVRNIESMGILQIEKAIGGMVKKARDGKLTMDDMTGGSFTISNSGVWGSLFGTPIINLPQTAVLGTYGTMDRPIAVNGQVEIRPMMYVALTYDHRIIDGREAVKFLVLVKKYLENPETMMLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPN6</accession>
    <name>A0A0G4PPN6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S027g000066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793160">
        <property type="protein sequence ID" value="CRL28377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PPN6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PPN6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL28377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="65" mass="7456" checksum="7A86306033A8BE8D" modified="2015-09-16" version="1">MMPDVLQNLMGSGPQSRADILVKRLIAVLGRKEQQSLWEDTDTNLKYFVPYYRALKALRKTSDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPW5</accession>
    <name>A0A0G4PPW5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cwf19-like protein, C-terminal domain-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S027g000093</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793160">
        <property type="protein sequence ID" value="CRL28404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PPW5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PPW5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061632">
        <property type="term" value="F:RNA lariat debranching enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07380">
        <property type="entry name" value="MPP_CWF19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF4">
        <property type="entry name" value="CWF19-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cwf19-like C-terminal" evidence="3">
        <location>
            <begin position="310"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="2">
        <location>
            <begin position="512"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL28404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="575" mass="64602" checksum="68807A47E5602B4D" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQ00</accession>
    <name>A0A0G4PQ00_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ankyrin repeat-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S028g000055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793161">
        <property type="protein sequence ID" value="CRL28502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQ00"/>
    <dbReference type="STRING" id="1429867.A0A0G4PQ00"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706:SF3">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_7G06200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706">
        <property type="entry name" value="SLR1338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="103"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL28502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="477" mass="51782" checksum="F372DF8785208209" modified="2015-09-16" version="1">MSENVHTHARSGTLTLENLGQLLIQFEVDDEDIYGDTALDVAIRHGHVGSVKLLLQAGADANRVPPGGKSPIYAATQAPNSGRIVELLLKHGSKPDEPVSDPKGDTPLMSAIRQGASPEAIRALVQAGASMDKANQIGETPKKLAEKSTNTAIHKAIRPKDEAPEWKPELENFLVSSGLFALAYFKNFKDVGLNAINRVAALSEPTPGQIPNPHTAEEFKSNLDNFIQAKGLEDFYPTGSEYVAQVAENSARILSSSAFAGATPKNVTIMSRQALYKPVFYCDDSGSMKDDNRMDRQATMVQRIASLITQAAPPAGALVDLRFINKSDKFNDISPSDLSSKMTFTPNGSTRLGTNLKGKVLEDFLYGPVRNGNGLKRPLLILTVTDGCPNEEPTSAYEDEIRASLDFVTANGYGEEAVRYDLSQVGNAPEATGFLRTWSMNSLVPQNVNVTAEHLDVGFENFRENDADLNDWVMTQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQU3</accession>
    <name>A0A0G4PQU3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S030g000061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793163">
        <property type="protein sequence ID" value="CRL28774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQU3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PQU3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40788:SF2">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL28774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="275" mass="31732" checksum="A658E03A78C21B26" modified="2015-09-16" version="1">MALRANNQFDYFDPDAGTYADHSLDTGSMDRSDPRTFSKSIGGFISEVMSPGNIRREAAARSDKISITYQTLHEILQRHEALIRKRWTKKTRQQRLKILLSAWPNMPAMHRPDFQAFAGHNKSIKYRDSYIWPYINLEDLLTTKTLPMLLNSRGRHHPSNFAGVDFDATKMGRVSNAVELIFLDNHTMIMDDLTENIKDYGKLVAWSENPDAFEWMTKQKQCIPGEGLLILEIQERLLTFLVQCCTQLLHDIPESTLTSDSFPVYRNRPLNPKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PR12</accession>
    <name>A0A0G4PR12_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S028g000114</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793161">
        <property type="protein sequence ID" value="CRL28561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PR12"/>
    <dbReference type="STRING" id="1429867.A0A0G4PR12"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF9">
        <property type="entry name" value="TAH-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="615"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="625"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL28561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="695" mass="77116" checksum="2992A841C8D51556" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PSA2</accession>
    <name>A0A0G4PSA2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S034g000083</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793167">
        <property type="protein sequence ID" value="CRL29285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PSA2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PSA2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF40">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="57"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL29285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="675" mass="75887" checksum="8E58CE2689A5A2A9" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PT27</accession>
    <name>A0A0G4PT27_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nop14-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S037g000037</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP14 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793170">
        <property type="protein sequence ID" value="CRL29550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PT27"/>
    <dbReference type="STRING" id="1429867.A0A0G4PT27"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007276">
        <property type="entry name" value="Nop14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183">
        <property type="entry name" value="NOP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04147">
        <property type="entry name" value="Nop14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="115"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="165"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="277"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="419"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="307"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="327"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="347"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL29550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="910" mass="103583" checksum="7185B31AEBD29ABE" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PTH5</accession>
    <name>A0A0G4PTH5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S038g000068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793171">
        <property type="protein sequence ID" value="CRL29665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PTH5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL29665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="57" mass="6399" checksum="D47EF87E8D26A2AC" modified="2015-09-16" version="1">MAWRDDGLCFLNNSHRYIRVKTRRALSLLGCDSRIGHLNDCHCSSAPTSLVTNGLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PTJ3</accession>
    <name>A0A0G4PTJ3_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide-methionine (R)-S-oxide reductase</fullName>
            <ecNumber evidence="5">1.8.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S039g000042</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(R)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="5"/>
    <dbReference type="EMBL" id="HG793172">
        <property type="protein sequence ID" value="CRL29733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PTJ3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PTJ3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.20">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00357">
        <property type="entry name" value="peptide-methionine (R)-S-oxide reductase MsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081:SF8">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MsrB" evidence="6">
        <location>
            <begin position="82"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL29733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="217" mass="24008" checksum="05F24AA14F132562" modified="2015-09-16" version="1">MRSRLSRNIISPLRHQTIPIRLAPTFSSSRLLSSSRKPPHSKASTKALRAAPAIPFFGAFFSSNRTPEQTTDAMSPPNQRSEDEWRTVLNPEQFRILREKGTERAGTGEYDSHYPSKGVYNCAGCDAPLYTADHKFKSGCGWPAYFDSIPGAVTRHVDNTFGMKRTEIVCTNCGGHLGHVFEGEGYQTPTDERHCVNSVSLRFTEDASAAKDPKAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PU17</accession>
    <name>A0A0G4PU17_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras small GTPase, Ras type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S042g000054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793175">
        <property type="protein sequence ID" value="CRL29995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PU17"/>
    <dbReference type="STRING" id="1429867.A0A0G4PU17"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="283"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL29995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="334" mass="36120" checksum="2885844542665EE1" modified="2015-09-16" version="1">MARQRGLSNASSTSSLPDQELGSMYDYLAKVILLGPSGAGKSCVLHRFVKDEWRVLSSQTIGVEFASRIVKLGTGSRRRRIKLQLWDTAGTERFRSVSRSYYRGAAGAILIYDVASYASFASLPTFLMDARALASPNLSVILAGNKADLTSDAQSDFEDNSRPPPTPSSTSSRQSSIPWDVNGSIRSTSLMGTGTRLTATRASEGREVSSEETSHWAAKSNIPVAVEISALTGDGVEEVFNRLARIILTKIELGEIDPDDPQSGIQYGDGGLYGGSDASSIRSRATLDDNSVPLQRRSRRKGKAPSTPNWKSGMREWEDVFRLGSGSRPNQGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUE7</accession>
    <name>A0A0G4PUE7_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">sterol 22-desaturase</fullName>
            <ecNumber evidence="7">1.14.19.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S041g000073</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.41" evidence="7"/>
    <dbReference type="EMBL" id="HG793174">
        <property type="protein sequence ID" value="CRL29931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PUE7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PUE7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000249">
        <property type="term" value="F:C-22 sterol desaturase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11082">
        <property type="entry name" value="CYP61_CYP710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000021">
        <property type="entry name" value="Cytochrome P450 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF228">
        <property type="entry name" value="C-22 STEROL DESATURASE ERG5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL29931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="534" mass="60144" checksum="C7EA5909EBD8B1C1" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PV54</accession>
    <name>A0A0G4PV54_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S048g000020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793181">
        <property type="protein sequence ID" value="CRL30308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PV54"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="126" mass="13720" checksum="9D3D4F70296B1961" modified="2015-09-16" version="1">MATEGENEILEVISSYSEPNDSETQGSNSESSEDDISETSEDRTCVVSDGDQSPYSNRSSGSSDYSQHCPDVQDNGSSDLIGQKIPIGTIAKRVIHQGDSSAVQYLVLWQSWEPEKPRVNGMAEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVC0</accession>
    <name>A0A0G4PVC0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histone-fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S044g000050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793177">
        <property type="protein sequence ID" value="CRL30119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PVC0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PVC0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="61" mass="6792" checksum="935883FD63993856" modified="2015-09-16" version="1">MEQSPQGSAQQGRQQPQPIYDVRNGGHYGKLQALSARLCASCRAVHWYLGQRKPRPSGNRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVQ4</accession>
    <name>A0A0G4PVQ4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S052g000030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793185">
        <property type="protein sequence ID" value="CRL30473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PVQ4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PVQ4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195875" evidence="2">
        <location>
            <begin position="23"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL30473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="319" mass="31937" checksum="98756339A58A9183" modified="2015-09-16" version="1">MLRISFLQLLFVTLFALTAVFAADAVQGTSSSESFQEALADIKAVKLHDALHALSAKFRHGIFPTDLQAAEALQAEEPTIASLIKLAKRQDNATATSPATVPTVTTASTESTSEPATTSAAETTETSETTSASSTEPTTSAEPTVTSATSASETSASETTSETTSETTSETSSATSASVSTETSSTVSTQTTAEPTTTTTESSTAETTQTTTSVPSTLSTTRSTSSASSTSTTSAQSTTSTHATSLSTSTFESTTTMPDGSLSTITSITVITPSATGGAAAATTAGKPGLQTNVAAMATGMAREVVAIVGGAVVVAMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVY5</accession>
    <name>A0A0G4PVY5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="9">3.2.1.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S052g000038</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="9"/>
    <dbReference type="EMBL" id="HG793185">
        <property type="protein sequence ID" value="CRL30481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PVY5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PVY5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF1">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE I_II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195785" description="glucan 1,3-beta-glucosidase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL30481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="388" mass="43944" checksum="E532F4FB1B9B2A9E" modified="2015-09-16" version="1">MLWKTVALVSLFASRAWGKPSRQTETSDYIDWKTFKANGVNLGGWLIQEPNIDPIWWDTYSGGAPDEWGLCKNLGSQCGPVLEERYATWITTSDIDKVARSGATLLRIPTTYSAWIQVPGSQLYSGNQTTYLHDIATYAIEKHGMHIILDVHGLPGGINGLTIGEADGHWGWFHNQTNFDYSMQVIDAIISFIQNSGHPESYTLEPMNEPTDNRDQAVFGTIAALSDKGAAWILKYIHAVLDRVASVNSQIPVMFQGSFKNEKYWSGNFTGRENMVFDVHNYYFAGRNTTSLNLPSFIRSDAKTRTGDRKFPVFVGEWSIQALHNNTHSLRAHNLNYGLKAFHHYSQGSSYWTWKFNGNDTIEGEGTQGDYWNYEYFVDNDYVHTDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PW12</accession>
    <name>A0A0G4PW12_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Multicopper oxidase, copper-binding site</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S055g000029</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793188">
        <property type="protein sequence ID" value="CRL30614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PW12"/>
    <dbReference type="STRING" id="1429867.A0A0G4PW12"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033215">
        <property type="term" value="P:reductive iron assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13877">
        <property type="entry name" value="CuRO_2_Fet3p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13899">
        <property type="entry name" value="CuRO_3_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000071">
        <property type="entry name" value="Conidial pigment biosynthesis oxidase Abr1/brown 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000022">
        <property type="entry name" value="FET5p Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044130">
        <property type="entry name" value="CuRO_2_Fet3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF361">
        <property type="entry name" value="IRON TRANSPORT MULTICOPPER OXIDASE FET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195666" evidence="8">
        <location>
            <begin position="19"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="11">
        <location>
            <begin position="27"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="150"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="364"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="550"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="893"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="965"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1008"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1094"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="550"/>
            <end position="576"/>
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        </location>
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        </location>
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        <source>
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        </source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL30614.1"/>
        </source>
    </evidence>
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        </source>
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</entry>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="166" mass="18401" checksum="917E007B6BE3F3CA" modified="2015-09-16" version="1">MHVKPSNMSLQIVAANSTRGSQQASIKKCVLQRLLSSWWLTETEKPTNTSSIPGNLLYDYSPVYIVDQQIRQCLSMDIRPYASARATASCGLFILVLTIRTLNLWELTRVALITLHYRQCSTQSHGLHTIPSPVASNNAACPRWKIANQDSESTTGCGHPRANFVA</sequence>
</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Renault P."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL30655.1"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PXM6</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
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        <property type="entry name" value="KR_dom"/>
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    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
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    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF18">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS/mFAS DH" evidence="7">
        <location>
            <begin position="199"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1566"/>
            <end position="1642"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="5">
        <location>
            <begin position="199"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="5">
        <location>
            <begin position="347"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="5">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="5">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL31088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1645" mass="179751" checksum="84409F5F318C093E" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PXP4</accession>
    <name>A0A0G4PXP4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S064g000010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793197">
        <property type="protein sequence ID" value="CRL30936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PXP4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="444"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="78"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL30936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="477" mass="54105" checksum="BF38246BAE345571" modified="2015-09-16" version="1">MLASSPESQTVSAILGEIAYQCEQVHARDKELKKAQDQVLDLKERKRVAIEEMFAANKGEKAKQKDALDRVESLCASVNQKDKRLTEYSKEVQGLRQQIDSIKSSYSLELDKVSQSAKDISTLQQNLKEKDKTINRMKTAGSSLKSMFSSAQKNIEELGAEKASLDQALQASQGPTPKPRKLHYLWVFASSEVFAILREDLDEEVLKVCLYLNPLSDYIHSSFDQKDKSIWDKLRKENTKIAQNNIPLVPLNSLEAKGMRLAMTMAILSRELCKYIFRPNYLLPDDSEIQGVLSHLAEDNTEKESFCRRVLLSIDHSAEERIRQTRIQTVIRNVSSYLWALLSETQHDSIRISIEKIRHETEFELVDFEIADCEPFHFPGDSALLDRQDQGARDMNILTVFPCISLVKDGGRDPLTHLIQLRSSQKLFVAAEHEASQMTTSVVVPRRSSTRSRRKSIAHNTDRPNGASFLEGKSPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PY32</accession>
    <name>A0A0G4PY32_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S117g000003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793248">
        <property type="protein sequence ID" value="CRL31319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PY32"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL31319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="117" mass="13045" checksum="1A3F091CEF2B89EE" modified="2015-09-16" version="1">MDPNKNEENSRSGPPVTSQHRKEDMALSSENKKQSSDLVPLGEEEKSRDASSRRSAHVLFGMEIDKGSVVFNGNARDKHPDKTQLHMINGGSVKNNSTLFNGDLDTETFKKIFGKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PYC5</accession>
    <name>A0A0G4PYC5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Altered inheritance of mitochondria protein 32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S088g000001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM32 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793219">
        <property type="protein sequence ID" value="CRL31208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PYC5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PYC5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902:SF7">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL31208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="361" mass="38928" checksum="9FDD1D2F333985B0" modified="2015-09-16" version="1">MQPILAQSLTRAWSGRTYRNCQNIRLLSSTPQRSSRLRVRLEIPPPFPVTKTCPEPSCNCPPTPALPEGLPIDHEQALNGTMAAYAQQLLICTGQPDWTSRIEDDGENKGWGNLVRGLKSLLGRGGPYLDPFNNVLVTNSSIAPAAGSSPSIASAFLFPSFKYIPSIPVNKTSSPDQTTDLTTFVRAYLLPERLHDMHSSLPAAKQADMTRSPDLASNFPGVIDINHSPTVLICGHGGRDMRCGAMAPALENEFKRVLQARGFTSADSDGTTVDGPNHANIGLISHVGGHKYAGNVIVYIPPKMTVGTSSEPHPLAGKGIWYGRIEPKHVEGLVDETILGGKVVTDHFRGGIDRSGDILRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PYE1</accession>
    <name>A0A0G4PYE1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioesterase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S127g000001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793258">
        <property type="protein sequence ID" value="CRL31346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PYE1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF1">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="1">
        <location>
            <begin position="123"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL31346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="215" mass="24215" checksum="2FBC19739562881A" modified="2015-09-16" version="1">MLSRPLYSKPDTEMPRQQIFHLIITCALSCASRASQRWFGLGQTYAKRIKIEDIISHPADKKSCVHPLASTGEPPQQPNSNSLRQELLRGYRPRIRKIGRGQEATATFTFQPQQRICYYTDKIHGGNQAFLMDHQFADCCKQNAAVTASLTVDFKYPIQPNTEVLLEARAIKIEGRKIFMKGSISIPEKETMVVAARATALFIIPKSNSTKEGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PYR4</accession>
    <name>A0A0G4PYR4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein kinase-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S4Jg000011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793313">
        <property type="protein sequence ID" value="CRL31489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PYR4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PYR4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052396">
        <property type="entry name" value="Meiotic_Drive_Suppr_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37171">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE YRZF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37171:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE YRZF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL31489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="262" mass="29442" checksum="91913A231DAAE693" modified="2015-09-16" version="1">MTRSSTNIELLQAEVAENYQSFFRLLVNGQRIKYVTINPGLYSADDMCFGPSLVSLLPALPAGDWNDGLVAKNETNGQPHFAYAIRTAFPGVKNVWNKTSVDYTEIVVGNKLRTGIYEVKCNLFDDVVVVKFARFDWEIQYLESETTAYQWIEGYDIGPRFLGHLTEDGRVIGFLMERIKDARHAGPQDLESCRKALSRLHCLGIHHGDTNRFNFLIRGSQAVLIDFDSARKCGDPDALQKELEHLPNSLEDLSRRGGGGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PZ58</accession>
    <name>A0A0G4PZ58_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S3Jg000046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793312">
        <property type="protein sequence ID" value="CRL31435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PZ58"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL31435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="106" mass="12068" checksum="8FE0073D9670DD05" modified="2015-09-16" version="1">MTGSAPPVSLNRHPLYSKGLENDFYCKCFESFHQLVSTTMDATQSLALQYHFNPANSPSGDPRLIRAIVSLRVALDKSRAEETSAEQEWKQQWKVSPVRQSSLRWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NSP3</accession>
    <name>A0A0G4NSP3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Phosphatidylinositol-glycan biosynthesis class S protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S001g000053</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGS family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NSP3"/>
    <dbReference type="STRING" id="1429867.A0A0G4NSP3"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019540">
        <property type="entry name" value="PtdIno-glycan_biosynth_class_S"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072:SF13">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10510">
        <property type="entry name" value="PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="533"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL17093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="569" mass="61928" checksum="3DD3BB336D727993" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NUW0</accession>
    <name>A0A0G4NUW0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein mS38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S001g000811</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mitochondrion-specific ribosomal protein mS38 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NUW0"/>
    <dbReference type="STRING" id="1429867.A0A0G4NUW0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013177">
        <property type="entry name" value="Ribosomal_mS38_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32035">
        <property type="entry name" value="AURORA KINASE A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32035:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08213">
        <property type="entry name" value="COX24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01155">
        <property type="entry name" value="DUF1713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein mS38 C-terminal" evidence="6">
        <location>
            <begin position="316"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="320"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="321"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL17851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="349" mass="38960" checksum="999557C33E9E2083" modified="2015-09-16" version="1">MLSTSLRRAAWTPMPLPGITRSGQTLTSSLLGATRPLHQRRYSSSSSKPPVPPSDGSRRMDTSAPAKGVNSSSEKSKANRRRGKDSSARNGSSKSSQHTAFSNLPSVPSTQHRQPHDVHVASFFSIHRPISVTTTVPPTSSTDAFEAIFSSKRPLKNEPEDVIFTLSSAVQSMETGPQGMSESEDQFRSFSEQDGELRMLDGPDAKLSVEEFTRRLRPFQPPPPPVPMDTSATETAESTDAQIDNEYQTYSTVLTIREARHADGRKTYEAHTGPFVRNGEMEDPSDVHDEISIEAPSDSNAGMTYMERLRNNRTMHAISTMRRRKAKMKKHKFKKLMKRTRTLRRKLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NUX0</accession>
    <name>A0A0G4NUX0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S001g000822</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NUX0"/>
    <dbReference type="STRING" id="1429867.A0A0G4NUX0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000223">
        <property type="entry name" value="Lipase/serine esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF65">
        <property type="entry name" value="ESTERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="DUF676" evidence="5">
        <location>
            <begin position="12"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="350"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL17862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="459" mass="50954" checksum="EFD2F52DFEC19EBC" modified="2015-09-16" version="1">MESTSETMPDTSKAEHLCVLVHGLWGNPSHLDYVASALRDRYGSDSLYILCPKANSGNYTYDGIELCGERIVHEIEETLESLAEKGQKITKISLIGYSLGGLIARYAIGLLNARGWLDKLEPMNFTTFATPHVGVRAPLKGYKNKIFNVLGPKTISASGRQMWLIDSFRDTGRPLLGVLADPESIFITGLKKFRQRSVYANIVNDRSVLFYTSGLSKVDPFRDLEDVNINYVQGYEDVIIDPDLHVLPPVQRGPETAAGRFWKKVNSVTRSIPLSLLIIVLAPLASALFLINAGIQTCRSSKRIRMHEVGENGERFGRYRVPVLIQDVQHVVEQAFENVTAIQEPAYLSNSDTEVSDVGPEKSTRSSLSKSAQNDAVGGSTSGRRLSTTEGSTHYPTLALTHEQFGIIDSLDAVGIRKYPVHIQKHHHSHAAIIVRVEKDGFREGKIVMKHWLDNEFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NVD6</accession>
    <name>A0A0G4NVD6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S001g001008</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL18048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NVD6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="137"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL18048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="619" mass="69339" checksum="D4743C02F3B6E375" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NVE0</accession>
    <name>A0A0G4NVE0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UDP-galactose transporter homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S001g000899</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NVE0"/>
    <dbReference type="STRING" id="1429867.A0A0G4NVE0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005459">
        <property type="term" value="F:UDP-galactose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005460">
        <property type="term" value="F:UDP-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL17939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="430" mass="46554" checksum="4E84D3AEA0D18681" modified="2015-09-16" version="1">MGRQKQAAPLQRAPSQLVQLSEESDAPQNTGTGNTNTVSTANGNVSEKASAALETVADSPGLTQLVICVLGIYAAFLSWGVLQEAITTTSYLVRPATVAEPNPPTERFTYSLVLNTIQSSFAAITGFIYLLFSTPKGQKIPSIFPTRRIIFPLVLVAISSSLASPFGYASLQHIDYLTFILAKSCKLLPVMVLHLTIFRKRYPLYKYGVVLMVTLGVATFSLHHPGTSKKVAAKDQSGSSGWGIFLLSINLLLDGLTNTTQDHVFSSPKLYTRFTGPQMMVAQNVLSTILTSAYLLSMPHLSRSGVLHNLLPFPIPPSTETELFGAFSFLSRHPEALKHVLGFAACGAVGQLFIFHTLSRFSSLLLVTVTVTRKMLTMLLSVFWFGHSLSGGQWLGISLVFGGIGAEAVVQRSEKKAKERSKIGAAKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NVI3</accession>
    <name>A0A0G4NVI3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S001g001076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL18116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NVI3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL18116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="72" mass="8792" checksum="47F25CBD0016945F" modified="2015-09-16" version="1">MTMGWLRHIFDKLSTMSEKRKKKNATKRRRREHSRRVREREKELRRRPGEKAPLFFGSPFKTYEVNYRGPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NVW1</accession>
    <name>A0A0G4NVW1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S002g000067</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NVW1"/>
    <dbReference type="STRING" id="1429867.A0A0G4NVW1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000061">
        <property type="entry name" value="Metalloreductase transmembrane component, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF23">
        <property type="entry name" value="FERRIC-CHELATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="14">
        <location>
            <begin position="358"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CRL18197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="738" mass="83941" checksum="37A7771B220C2844" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWQ4</accession>
    <name>A0A0G4NWQ4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enolase</fullName>
            <ecNumber evidence="3">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S002g000408</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Mg(2+) is required for catalysis and for stabilizing the dimer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="3"/>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWQ4"/>
    <dbReference type="STRING" id="1429867.A0A0G4NWQ4"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902:SF6">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00178">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enolase N-terminal" evidence="14">
        <location>
            <begin position="2"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase C-terminal TIM barrel" evidence="13">
        <location>
            <begin position="143"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="369"/>
            <end position="372"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CRL18538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="435" mass="47273" checksum="B62049273D522C53" modified="2015-09-16" version="1">MIRSIQAAQRLDSRGHPTVQVDLTTDKGTFRATVPSGASTGANEAIELRDKDSSAYGGKGVQKAVSNIELVIGPALVQSGLKVNTHQKMIDCFLNNLDGTHDKSKLGANAILGVSMACARAGAAHLDIPLYEFLRRESGGKKPYVMPVPFFNVLNGGVHSGNKMAFQETMIAPVGASSFTEAVQMGSEVYQQLKKVIVKKFGPSATGVGDEGGFAPPISQPHEALDLLVEAVSLAGYTGGIKFAIDPASSEFFRDGNYDIGFKDDKPNLQSPKQLAELYRSLLQNYPIVLLEDPFAETDWDSWIEFNKNCPVELVGDDLLVTNTKYVREANDKRACNSMLLKINQIGTISEAIEAANLAYSFDWSVFVSHRSGETTDDFIADLVVGLRTGHIKPGAPCRGERVVKDNRLMEIEAEILAREECIYAGSQFRVASKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWZ6</accession>
    <name>A0A0G4NWZ6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S002g000440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWZ6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL18570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="138" mass="15449" checksum="58A638DA839090C9" modified="2015-09-16" version="1">MGVERDWLEKGEEERQSVAGCWTGVEGSLSLDMDILLSLPFPRKPNCNIVIAMHCCIAAIPCAHVRVRCLNIQLPTYIPHPSIHPLNASGLQDSKEDPVRRSRKVTYYVPLESGHSEAPCHCLSCLRASRQDKKQTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NX35</accession>
    <name>A0A0G4NX35_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S002g000557</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NX35"/>
    <dbReference type="STRING" id="1429867.A0A0G4NX35"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03758">
        <property type="entry name" value="proteasome_beta_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000008">
        <property type="entry name" value="Proteasome subunit beta type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035206">
        <property type="entry name" value="Proteasome_beta2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL18687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="182" mass="20269" checksum="A7A4B13CA28F5CF6" modified="2015-09-16" version="1">MRGPTVLKAEDDKTRQLNKHTLMAFSGESGDTVQFAEYIQANAALYSMRNDTELSPSAVANFVRGELARSLRSRSPYTVNLLLGGIDPVTEKPHLYWVDYLASLAPLPYAAHGYAQYYCLSILDKHHHPDCSLEEGLALLTLCTDELKRRLPIDYKGMLVKVVTKDGVQEIAVDNDKVVRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXC3</accession>
    <name>A0A0G4NXC3_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">penicillopepsin</fullName>
            <ecNumber evidence="6">3.4.23.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PCAMFM013_S002g000638</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted aspartic endopeptidase that allows assimilation of proteinaceous substrates. The scissile peptide bond is attacked by a nucleophilic water molecule activated by two aspartic residues in the active site. Shows a broad primary substrate specificity. Favors hydrophobic residues at the P1 and P1' positions, but can also activate trypsinogen and hydrolyze the B chain of insulin between positions 'Gly-20' and 'Glu-21'.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1', but also cleaving 20-Gly-|-Glu-21 in the B chain of insulin. Clots milk, and activates trypsinogen.</text>
            <dbReference type="EC" id="3.4.23.20"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.20" evidence="6"/>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NXC3"/>
    <dbReference type="STRING" id="1429867.A0A0G4NXC3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000085">
        <property type="entry name" value="Aspartic-type endopeptidase (CtsD), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000060">
        <property type="entry name" value="Aspartic-type endopeptidase ctsD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF75">
        <property type="entry name" value="ENDOPEPTIDASE (CTSD), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 19" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 21" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005194865" description="penicillopepsin" evidence="21">
        <location>
            <begin position="19"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="22">
        <location>
            <begin position="106"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="426"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="426"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="active site" evidence="17">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="active site" evidence="17">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="137"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CRL18768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="496" mass="53244" checksum="4B8D83E64B0C13EA" modified="2015-09-16" version="1">MHLSSCLVFIVGISGVHAFYPWELRMKLSTETSVERRFVPWNLIEVKSDDESTDSTDISNTADKPWTLDLKKMPVRRNDGYKIVESHKPSLANSAPLNQDGTDYSYFSPVHVGSQKQEMWMAIDTGAPNTWVFDSKCIEPVCTRHHKFDQSASTSYTTDDSTFSLFYGSGKVSGKMGKDTLSIAGLEVSQTFGLANNASETFQSYPFDGILGLGRSRTEGWNLPSFMDLVAEKKLIKSNLVGFSLSRSSDNNKDGEINFGGVDTTKFDGTISYTATNEKIWSIPVDDAYVNGQSCNFTGKSATIDTGTTYLLIPPADAKTLFSLVPHSSQQPSNPNNYLIPCNSTATIEFEFSGVKYNVSPKDYVGNAESDGSAYCISTIVGYASNGANWLVGDVFLKNVYTVFDFDNGQIGFGALASASASNSNSSSTSSSSSSTSQGNGTFTAPPVTGTAASAADPTSSSTSSTMATVSDSSASHLIRGISWSMLTVMLGAFAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXN0</accession>
    <name>A0A0G4NXN0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Iron-sulfur cluster assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S002g000712</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; iron-sulfur cluster biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NXN0"/>
    <dbReference type="STRING" id="1429867.A0A0G4NXN0"/>
    <dbReference type="UniPathway" id="UPA00266"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1010.10:FF:000005">
        <property type="entry name" value="Iron-sulfur cluster assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011339">
        <property type="entry name" value="ISCU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01999">
        <property type="entry name" value="iscU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY ENZYME NIFU HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="NIF system FeS cluster assembly NifU N-terminal" evidence="10">
        <location>
            <begin position="48"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL18842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="201" mass="21223" checksum="A6E5F44D3040DE1A" modified="2015-09-16" version="1">MFKRLVTVAPRVGSVATRSALSPLTGLQSAQPAIRRAAPAPAQQRRGYHEKVLDHYNNPRNVGSMQKGDQDVGTGLVGAPACGDVMKLQIRVNKDSGRIDDVVFKTFGCGSAIASSSYLTELVRGMTLDEAGRVKNTDVAKELCLPPVKLHCSMLAEDAIKSAIANYYTKNPNTRATDLSGTGGVIPDVKVETAGSPAASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXN9</accession>
    <name>A0A0G4NXN9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial outer membrane protein porin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S002g000690</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Forms a channel through the cell membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic mitochondrial porin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NXN9"/>
    <dbReference type="STRING" id="1429867.A0A0G4NXN9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07306">
        <property type="entry name" value="Porin3_VDAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.10:FF:000004">
        <property type="entry name" value="Por1 mitochondrial outer membrane porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001925">
        <property type="entry name" value="Porin_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743:SF70">
        <property type="entry name" value="GH26960P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00185">
        <property type="entry name" value="EUKARYTPORIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00558">
        <property type="entry name" value="EUKARYOTIC_PORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-0626">Porin</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL18820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="284" mass="29863" checksum="0CD1BD3D94270711" modified="2015-09-16" version="1">MSAPAAFSDIAKATNDLLNKDFYHGAAANLEVKSKAPNGVTFTVKGKSAHEGPIAGQLEAKYVDAPTGLTLTQAWTTANALDTKLELDNNIAKGLKAEILTQYQPAKQSKGAKLNLYFKQPNLNARAFFDLLNGPSANFDAVLGHEGFLVGAEGGYDVNKAAITKYSAAVGYSVAQYSAAITASNNLSLFSASYYHRVNAQVEAGAKASWDSTSGNAVGLEVASKYRLDPSSFAKAKINDRGIAALAYNVLLRPGVTLGLGASFDTQNLNQAAHKVGASFTFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXU9</accession>
    <name>A0A0G4NXU9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S002g000679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NXU9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL18809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="83" mass="9141" checksum="CB258CA92B3EAF09" modified="2015-09-16" version="1">MISSISLCWSCAPVAATVVTGLGLVLPALVLVVLYLRAHRGLKRTADLTSTQGSMIKIPTWKRSYGLDVQLPYRRESYGFEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYT7</accession>
    <name>A0A0G4NYT7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S003g000041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NYT7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006771">
        <property type="entry name" value="CetA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04681">
        <property type="entry name" value="Bys1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195013" evidence="1">
        <location>
            <begin position="18"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL19250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="170" mass="18177" checksum="A4DE974495BEA733" modified="2015-09-16" version="1">MKTSLFTFGAFAGLVSAQNAIVYNNCDTSVYVQSFPVDGSAPGPLTTLANGETFSEAFRESGSTVKIAKTKTLDTPLFFGYSFSSNPDYVYYELNTQWGNPFAADSNSLSPGDGCAAFDCAANDAACYSTDADKKVYGCPQPVTLTADLYLRKAHKCARTPGPKPNPQWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZ53</accession>
    <name>A0A0G4NZ53_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S003g000137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZ53"/>
    <dbReference type="STRING" id="1429867.A0A0G4NZ53"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL19346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="138" mass="14339" checksum="25AF71AF816E8877" modified="2015-09-16" version="1">MSASRFAPLLRTRVAVQTAPSFQAIRSISATAPCNKGPVDATKETLKKADRTVSDVAVKGINTGEKAANKLKDVVGSGAKQAREKGEEVKGEASEYAGKAKGEAAEYAGKVKGEAAEYAGKGKGKAEEALNEAKQKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0B5</accession>
    <name>A0A0G4P0B5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S003g000553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P0B5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL19762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="79" mass="8482" checksum="C3BF43BAFC10A119" modified="2015-09-16" version="1">MACIACRGLIGSTGSMGSMTTRQIPMQAREGQAPTSPGIPRTTEAATAGPHSWPRTVGPRFQITHPLQLVQMFTYLPDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P118</accession>
    <name>A0A0G4P118_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pyridoxal phosphate-dependent enzyme, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S003g000802</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL20010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P118"/>
    <dbReference type="STRING" id="1429867.A0A0G4P118"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008721">
        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030378">
        <property type="term" value="F:serine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018114">
        <property type="term" value="F:threonine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000005">
        <property type="entry name" value="Threonine dehydratase catabolic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050">
        <property type="entry name" value="SERINE / THREONINE RACEMASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050:SF1">
        <property type="entry name" value="SERINE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="5">
        <location>
            <begin position="58"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL20010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="355" mass="38049" checksum="4E85CDCF54BEF0AD" modified="2015-09-16" version="1">MAELSTCLPLTRESTLKAHELIKPLIHRTPVLTSRALNQMVSTPQAQGKGDCQPAKPVIRLWFKCENLQRIGAFKARGAFHAIERLKQDPSFTERGGMEKGVVGFSAGNHAQALALAAKESGIPAYIVMPDMTRPNKIAATKGYGANVIVCPRFERETTAAKIVAEKGARLVPPFNHPDVILGQATAGLELQEQADNLDAIIAPCSGGGLLAGTALSCEGTSIRVFGAEPEFEGADDCRRGFLTGERVTSVNTNTIADGLIGVVGELPWSVIYERKLVDGMFAVSEEQILEATRLILERLKMVVEPAAAVTLAVTLYNEEFRQIVEKEAGEKGWDLGLILSGGNVSAEGLAKLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P1K3</accession>
    <name>A0A0G4P1K3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S004g000142</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P1K3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF56">
        <property type="entry name" value="DUF895 DOMAIN MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL20202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="465" mass="50944" checksum="16367B41757CB3A2" modified="2015-09-16" version="1">MAPPIEPEVTSEAHNDSQTITRSRSSWYRSIPFQIAVASGVSFTAPGMWDALNNLGAGGAAEPYAVSAANALVYGLFAIVCVAAGAINNRIGLRYGLVLGAIGYPIYGAGLYTNNYHPTTWFLLFGSALCGISAGFFWAAEAAIIIGYPSPKERAFYIAIWQTAKSSGPIVGGAISLGLNAQSSKKGTVSASTYIVFIVIMCLGLPISLLLSPAEKVQRKDHSLVIVDKKETWAKEFKAAFSLIFTRRVLLLLPAFFISYFYNGFQSTFLTTYFTVRSRAFSSFLTNFAGIASSFIWAALLDRQSIFIKTRARIAFCSIIILIIGTWIWATILQKQYYDAPEPPMFDWFTSGFNKAYALVFFWNFSGQAFQQFLYWLVGQYSTDISSLSYHCGILRGFEALGQTVAWAMQTEGGANHFVSIGLNFGITVLAFVPTWIVLSELEHSHEVQVTVEDVAPKTVGESTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P1P4</accession>
    <name>A0A0G4P1P4_PENC3</name>
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        <recommendedName>
            <fullName evidence="8">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="7">3.4.21.92</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S004g000181</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S14 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CRL20241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4P1P4"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:endopeptidase Clp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000001">
        <property type="entry name" value="ATP-dependent Clp protease proteolytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001368">
        <property type="entry name" value="PRK00277.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381:SF11">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CLP_PROTEASE_SER"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="168"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL20241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="258" mass="28019" checksum="6F2E8E6CCF02943F" modified="2015-09-16" version="1">MLSRASVRQIGRSIQNSPVAITRPAAVFARCFSNQGPSLAQPPRSWTPTPFVTETVGGGWHTYDIFSRLMKERIICLNGEVDDTLSASIVAQLLFLEADNPAKPIHLYINSPGGSVTAGLAIYDTMTYIASPVSTICVGQAASMGSLLLAGGEAGKRYCLPHSSIMVHQPSGGYFGQASDIAIHAKEILRVRTQLNEIYQRHLTGKKQLSLDEIEKLMERDYFMGAKEALELGVIDEILDRRVQGKEGSGEESKPPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P247</accession>
    <name>A0A0G4P247_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA replication checkpoint mediator, MRC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S004g000330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4P247"/>
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    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Claspin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018564">
        <property type="entry name" value="Repl_chkpnt_MRC1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14396">
        <property type="entry name" value="CLASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14396:SF10">
        <property type="entry name" value="CLASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09444">
        <property type="entry name" value="MRC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication checkpoint mediator MRC1" evidence="5">
        <location>
            <begin position="901"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
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        </location>
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        </location>
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            <end position="723"/>
        </location>
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            <end position="832"/>
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        </location>
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            <begin position="1"/>
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        </location>
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            <begin position="225"/>
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        </location>
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        </location>
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        </location>
    </feature>
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        <location>
            <begin position="388"/>
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        </location>
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        </location>
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    </feature>
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        <location>
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        </location>
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        </location>
    </feature>
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        <location>
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    </feature>
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        </location>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1300"/>
            <end position="1314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL20390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1314" mass="143851" checksum="4BE7751435D15FAB" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-11-27" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2F1</accession>
    <name>A0A0G4P2F1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mitochondrial glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S004g000438</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P2F1"/>
    <dbReference type="STRING" id="1429867.A0A0G4P2F1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.280.10:FF:000007">
        <property type="entry name" value="Regulatory protein SUAPRGA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.280.10">
        <property type="entry name" value="Mitochondrial glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003428">
        <property type="entry name" value="MAM33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036561">
        <property type="entry name" value="MAM33_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826">
        <property type="entry name" value="COMPLEMENT COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826:SF1">
        <property type="entry name" value="COMPLEMENT COMPONENT 1 Q SUBCOMPONENT-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02330">
        <property type="entry name" value="MAM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54529">
        <property type="entry name" value="Mitochondrial glycoprotein MAM33-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL20497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="287" mass="32404" checksum="79C95F206174FE9A" modified="2015-09-16" version="1">MLSLRTITRSIPRTFSRSIATSALRPAFPKPALQQSWKQATKPAYAAFSTSSIFKAPSSEVDVELLAKLEDELKHEKSSEIPEFEEQLEAIEETIKHGEWQVKDVAGDQEVILTKKFGTENIRVTFTVADIQNISEQEDFDDASLADEMDFQNRGQDAEAAAEEDIEQPEPSFPARVTITVEKPNNGALLIQTVVQDGVFQIEEVSHFAKAELAQSLTAEKDWARQSLYAGPPFENLDEDLQGLWDRYLEDRGLNAEFANMVPDYISVKEQKEYLRWLETVKNFIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2P4</accession>
    <name>A0A0G4P2P4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uroporphyrin-III C-methyltransferase, yeast</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCAMFM013_S004g000537</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Siroheme synthase involved in methionine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>uroporphyrinogen III + 2 S-adenosyl-L-methionine = precorrin-2 + 2 S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32459"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.107"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P2P4"/>
    <dbReference type="STRING" id="1429867.A0A0G4P2P4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000006">
        <property type="entry name" value="Siroheme synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000504">
        <property type="entry name" value="Siroheme synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.950.10:FF:000005">
        <property type="entry name" value="Uroporphyrin-III c-methyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012066">
        <property type="entry name" value="Met1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028162">
        <property type="entry name" value="Met8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050161">
        <property type="entry name" value="Siro_Cobalamin_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790">
        <property type="entry name" value="SIROHEME SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790:SF6">
        <property type="entry name" value="UROPORPHYRINOGEN-III C-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13241">
        <property type="entry name" value="NAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14823">
        <property type="entry name" value="Sirohm_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036555">
        <property type="entry name" value="SUMT_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75615">
        <property type="entry name" value="Siroheme synthase middle domains-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="2 12 16" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 12 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Siroheme synthase central" evidence="15">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme biosynthesis protein Met8 C-terminal" evidence="14">
        <location>
            <begin position="227"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="13">
        <location>
            <begin position="284"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CRL20596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="562" mass="61217" checksum="7095F0276FD444CF" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P366</accession>
    <name>A0A0G4P366_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S004g000685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P366"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL20744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="108" mass="12011" checksum="4B706BA1ACD1CD30" modified="2015-09-16" version="1">MEYFVLRTSMHTAPAKTQAQQALPTTTLALVDSPLLSTPPHDHRTPNSMTSRRLDRKKGAGQRPNARQDDNAGGRDARRGLASVDRYMMSAISRSREGGKFLAWCLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P399</accession>
    <name>A0A0G4P399_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S004g000715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
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    </evidence>
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    </evidence>
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</entry>
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            </authorList>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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    </evidence>
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    </evidence>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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            <dbReference type="EMBL" id="CRL20939.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="57" mass="6253" checksum="5D556A533CD85F92" modified="2015-09-16" version="1">MTGLEHGFPNTGAHGTMLLAVMLDRRGDLDGSLNQERQTRIGDLRRQDTACIASMSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P458</accession>
    <name>A0A0G4P458_PENC3</name>
    <protein>
        <submittedName>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        </location>
    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="240" mass="26016" checksum="9CBA9CCC8B4A04BB" modified="2015-09-16" version="1">MPTKYGSPTVGRDVDTQWVQWLARRKTPIASPPSSSTPVPMPSATLHDSGPLHSRSTATSYFALLSAAQGQQQPRRQGRPQTPSPSMDSSWGTWLFDRGPRGSKRPTSAGVNPQMQTTSIEPQLTSTAPAFAVSSLDPLHFPLTTPLMDSESIPGVSDEALGEFDLGLDVDLTGQGAELLTWLDEEYSFTMETPVCSGKRGLDSPRELSVSKKQIVDCRSDLGRAPTGIYGCEYRPYSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P4U5</accession>
    <name>A0A0G4P4U5_PENC3</name>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Dupont J."/>
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                <person name="Debuchy R."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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            <begin position="56"/>
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        </location>
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    </evidence>
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            <dbReference type="EMBL" id="CRL21330.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="73" mass="8188" checksum="7A36DCF21782C622" modified="2015-09-16" version="1">MSLIHKLQAKLELYRLEQRYARRKHRSTFSTGAQYVDGEYVYSGVSSPTSTVSKNSTGSWRPSGWGSGSQSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P513</accession>
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        <submittedName>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Lacoste S."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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            <end position="315"/>
        </location>
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            <begin position="379"/>
            <end position="414"/>
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        <location>
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            <end position="588"/>
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            <end position="481"/>
        </location>
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            <end position="554"/>
        </location>
    </feature>
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        <location>
            <begin position="561"/>
            <end position="572"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL21387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="588" mass="65839" checksum="5EACA964C79AE179" modified="2015-09-16" version="1"> </sequence>
</entry>
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        <submittedName>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
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    </dbReference>
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        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
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        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AMINOTRANSFERASE CLASS I_CLASSII DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="89"/>
            <end position="414"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="422" mass="46229" checksum="558068F3EA379E06" modified="2015-09-16" version="1">MMLSSRGSENVKELAKPWRFSLTQTYDPEENPTGLISFGMAENKPMRAEIAKYINEKVVFTQDSISYRSSAPTAARLPAAAAVHLNNILNPHTPINAEDVFVADSPTSLGSMLGYSLAECGDGILVSRPVYGRFELDYGVESGVEMVYADTATEETFSPISVEKYELALKAANERGQKIRAVLLVNPHNPVGRCYPVETLKAIARFCNRHKLHLISDEVYASCVFDSGDPNAVPFTSILSLDFTGLIDPDLVHVLYGFSKDFASGGLHLGFLVTPNQQLRQACKAIQRLHGASQAAVTIGTTILEDQAFVASFTAKARQRLASAYRITTSVLNREGINYVKGGNAGFFVYIDLSPYLPTDGGLSPRNREFALAQRLVDAGVFLHPGEEHSRDIGWFRLVFSQEEETLKEGLNRLLGVLKSSA</sequence>
</entry>
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    <accession>A0A0G4P652</accession>
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        <submittedName>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
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        <location>
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            <end position="74"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL21739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P659</accession>
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    <protein>
        <submittedName>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="155" mass="16525" checksum="8EFAB5BD130E8EF8" modified="2015-09-16" version="1">MVESFDTSSLQDSLNLPFPATTKQIAGLVNGVQTDVVIMNFSDKIMVTISQAGRLAHWLHVPMENQNPGTEGMHTLAEGDDALLPLKSLTTTTLLGGYSPGQDTTGQLLARQIATAIATKTPSEKRLLLVGLGLGKSTADRDSFFAIVDLVLQCL</sequence>
</entry>
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    <protein>
        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
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                <person name="Lacoste S."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4P7B7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056672">
        <property type="entry name" value="DUF7770"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24968">
        <property type="entry name" value="DUF7770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7770" evidence="1">
        <location>
            <begin position="19"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL22211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="164" mass="18806" checksum="EFC5ACD8027038CA" modified="2015-09-16" version="1">MVNLNPNQVLADTRRVSCIRVVVHAGAATDGSDNHWSLYLLLQHGGSVRVNMVTDYGDIDGRLEWSDLAYLLTNSAIQHWDFPVTLAIEVRHVADTIYRNSRHQYQFSGGGSGCRFWVRTIVHDIESRNYIAAGTSNELWRHLQYLYRRGKDPLQINWVQGAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7I8</accession>
    <name>A0A0G4P7I8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S007g000238</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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    </organism>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
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            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="102"/>
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            <begin position="1"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="6">
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            <end position="119"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
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        </source>
    </evidence>
    <sequence length="735" mass="81550" checksum="8F5E83E1BBC4C214" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P814</accession>
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        </recommendedName>
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    </gene>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
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            <dbReference type="ChEBI" id="CHEBI:17029"/>
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        </reaction>
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    </comment>
    <comment type="similarity">
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        <property type="term" value="C:cell septum"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:chitin synthase activity"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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        <property type="entry name" value="CHITIN SYNTHASE B"/>
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    </dbReference>
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        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="582"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="627"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="660"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="706"/>
            <end position="729"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="844"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="884"/>
            <end position="904"/>
        </location>
    </feature>
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        <location>
            <begin position="145"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
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            <end position="64"/>
        </location>
    </feature>
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        <location>
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            <end position="139"/>
        </location>
    </feature>
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        <location>
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            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CRL22432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="915" mass="101680" checksum="F5212446D6D80638" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P8F7</accession>
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        <submittedName>
            <fullName evidence="8">Str. FM013</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">PCAMFM013_S007g000530</name>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CRL22549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="23"/>
            <end position="60"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL22549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="94" mass="10911" checksum="86CDCBBCB6F6A28A" modified="2015-09-16" version="1">MDQNPNKVSTQSRSDKKSLRQKRDRRRLNLEKKLHQYSKLCGADVCLGIRIRDTGRVFTFSADRSGFWAFLSSKLSSYYPKPIQKSGEDLENAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P8M8</accession>
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            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="3 4">
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4P8M8"/>
    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
    <dbReference type="InterPro" id="IPR025509">
        <property type="entry name" value="DUF4396"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4396" evidence="2">
        <location>
            <begin position="83"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL22657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="222" mass="24736" checksum="FF80D351EE21CB41" modified="2015-09-16" version="1">MPKPDMSQMRHPFLLQRSRGICWVSRRAFSGTTRAQACHTEKNQCTKSIERENQLSQPPKCTKKPPTQPLPTLSLPFWTCRSTWKRAGINTLRCLVGCTAGDFSALWILQTYYPEMGMSSIMALSMASGITTSVILETILLRRGADQLSWPMAARTAMGMSMVSMLAMELAENAVDYHLTGGIVAFGDPKFWMAAVLSMGAGYLAPLPYNYLRLRKYGKACH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P8R2</accession>
    <name>A0A0G4P8R2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Pre-SET domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S008g000121</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
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        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="H3K9_Histone-Lys_N-MTase"/>
    </dbReference>
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        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223:SF3">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SET-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05033">
        <property type="entry name" value="Pre-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Pre-SET" evidence="10">
        <location>
            <begin position="245"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="324"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="11">
        <location>
            <begin position="470"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
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        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50867"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL22692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="497" mass="55668" checksum="DFDBADD91F0D8CCC" modified="2015-09-16" version="1">MAGRVSGANQNRVFIDLTDETDPGDSEVPKNLVQDKLPFVTALAYHPPTVPLKRKSVDISEDASDTSSSDIQRLPRRARLSHAHPSPSPSPHTPSPPNIKPSQISVVIPSPTSKQRREIAIAQNVSNVDGMDINIFPTTDEQERVKKAAYPTTKARVDRRSIPLSFKSSSDLNILNLPSLAEANHLAKLRHTLDEKLKHINGPSVITAVESPQRLAKLADNFEFINGYQYRAGVERIPDDSDFNIGCACTETDGCDRFECDCLSKEEDSEDRIVPYEICESNPRLIVANKSFLKRKAIIYECNSRCGCKGTRCWNHVVQKGRTVRLEIFDTGSRGFGLRSPDLIHRGQFIDLYLGEVITKAEADERENLTDGSHTQSYLFSLDWYVKDDDDEEENMKVIDGRKFGSATRFMNHSCNPNCKIVPVCTTNHADEYLYNLAFFAYRDISPGTELTFDYNQGEENTTPQKIDPEAVPCLCGESKCRGQLWPNKRKGQGSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P900</accession>
    <name>A0A0G4P900_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acyl-CoA oxidase/dehydrogenase, type1/2, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S008g000220</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P900"/>
    <dbReference type="STRING" id="1429867.A0A0G4P900"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052904">
        <property type="entry name" value="Acyl-CoA_dehydrogenase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041504">
        <property type="entry name" value="AidB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42707:SF2">
        <property type="entry name" value="ACD11 DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42707">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18158">
        <property type="entry name" value="AidB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adaptive response protein AidB N-terminal" evidence="7">
        <location>
            <begin position="24"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="6">
        <location>
            <begin position="188"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="5">
        <location>
            <begin position="312"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL22791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="634" mass="70079" checksum="F6E20196062C5F3F" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P984</accession>
    <name>A0A0G4P984_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S008g000296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P984"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL22867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="80" mass="8718" checksum="24521E62ECA651F9" modified="2015-09-16" version="1">MPWSLAVLGAKSQRPSGNWWLVLTPRTEDCRLGSKAGHHQGIDPLMLQGSPSTAHSGFEGSFRLAFILHSPYSCALQKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAA5</accession>
    <name>A0A0G4PAA5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RTA1 like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S009g000191</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PAA5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PAA5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF1">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL23251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="297" mass="33106" checksum="A75B94F8D0BDD330" modified="2015-09-16" version="1">MASNTGGEIDFKLYRYTPSLVAAILFTVLFVLATFYHLYQVVRTRAWYFIVFVIGGAFQIIGYICRALAHKNKENVPLYSISTIMILLAPPLYAASIYMTLGRLVTHLNAEKLSMVPVKWLTIIFVTGDVVAFLMQAAGGGIMASGTLSAMTTGEHITIGGLAVQLVFFSVFITAATIFHYRIRKNPTERCFNPLHSSGVLHMPTWEIVMTGLYVASILILIRSIFRLIEYAQGNSGYLISHEAFLYVFDSTLMLFTMVAMSVFHPSKILSQSTRPLRSSTRSRSANKESPSTREEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAX6</accession>
    <name>A0A0G4PAX6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S009g000413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PAX6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL23473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="276" mass="30836" checksum="5C1952A34CD47D4A" modified="2015-09-16" version="1">MAEETRWCGICRKERPNDAFRAPEGAGKDFYKMCEPCRTKYRDVRISHAQMGKRIRSRIRSGLKETQRSRVKRARANRGRSWPYYLSEPAPQTSIDLPNSETRVTSETTSAAQTTPMPEQPNGMHADSGHHSRVTVAPPVVESSAQSTTTTTVITISTTTVSKNVTETSNKPAEGAKTAPDSIQQVKDEDLESLSSGPEPEQQSEIGAGTNRHPEFFGCLHCEKLRPWPMAGLHICLLCIRDWKWCVKGAHNQAKASFIWDGEEHDECYICQFAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PB09</accession>
    <name>A0A0G4PB09_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">glucan endo-1,6-beta-glucosidase</fullName>
            <ecNumber evidence="13">3.2.1.75</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Beta-1,6-glucanase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Endo-1,6-beta-D-glucanase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Endo-1,6-beta-glucanase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PCAMFM013_S009g000394</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall. Acts on lutean, pustulan and 1,6-oligo-beta-D-glucosides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Random hydrolysis of (1-&gt;6)-linkages in (1-&gt;6)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.75"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.75" evidence="13"/>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PB09"/>
    <dbReference type="STRING" id="1429867.A0A0G4PB09"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046557">
        <property type="term" value="F:glucan endo-1,6-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000269">
        <property type="entry name" value="Probable glucan endo-1,6-beta-glucosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF39">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 17" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 17 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195391" description="glucan endo-1,6-beta-glucosidase" evidence="18">
        <location>
            <begin position="20"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="19">
        <location>
            <begin position="84"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00036633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00043257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CRL23454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="400" mass="45837" checksum="25A4EF43088E582B" modified="2015-09-16" version="1">MRILFKYATLTTLFTLTNAWLPEENKSITSKDGTNLFKSSNGTIRGVNLGSQFIFEPWIAHNAWNDMGCKGEKSEFDCVSSLGQDAANTAFAKHWASWTTQDDLDEIVSYGLNTIRVPVGYWLHEDLVDVDSEHFPQGGLEYVKKLCGWASDKGLYIIMDFHGLPGAQTANNSFTGQYVAQTGFYTDENYERALKWLEWMVKLVYQTDEMRNVGMLEIVNEPVRNEVKALSMRSKYYPKAVERIRAAEKKLSIDAKDRLHIQTMDKSWGSGDPNEYLDDVTYMAYDDHRYLKWDTSVDPTHDNYISTSCADKRDSNSPNIIGEWSLAVADEVAKSSDWDPSSNTDFYGKWFAAQVHSYEQQQGWVFWTWKSQLNDYRWSYQDAVKAGVIPKDLNSLKNVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PB76</accession>
    <name>A0A0G4PB76_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Signal transduction histidine kinase, homodimeric</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCAMFM013_S009g000464</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4PB76"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009584">
        <property type="term" value="P:detection of visible light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000048">
        <property type="entry name" value="Sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.270:FF:000002">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013654">
        <property type="entry name" value="PAS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016132">
        <property type="entry name" value="Phyto_chromo_attachment"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001294">
        <property type="entry name" value="Phytochrome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013515">
        <property type="entry name" value="Phytochrome_cen-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043150">
        <property type="entry name" value="Phytochrome_PHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43065:SF10">
        <property type="entry name" value="PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43065">
        <property type="entry name" value="SENSOR HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08446">
        <property type="entry name" value="PAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00360">
        <property type="entry name" value="PHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01033">
        <property type="entry name" value="PHYTOCHROME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50046">
        <property type="entry name" value="PHYTOCHROME_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="6 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="1" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Phytochrome chromophore attachment site" evidence="13">
        <location>
            <begin position="425"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="14">
        <location>
            <begin position="801"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="15">
        <location>
            <begin position="1264"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1073"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1134"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1075"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1085"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1134"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1160"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1173"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="11">
        <location>
            <position position="1315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CRL23524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1420" mass="156971" checksum="BD058D68CEBBB040" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBY1</accession>
    <name>A0A0G4PBY1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase aspartic, active site</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S010g000253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PBY1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PBY1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.320">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010323">
        <property type="entry name" value="DUF924"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06041">
        <property type="entry name" value="DUF924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL23815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="259" mass="29421" checksum="EF160FB8C9D7602F" modified="2015-09-16" version="1">MASSSELKRTLTPTLLDDVHKLWFDHLSCDEALVLPGWSDMGKWFSHDEAFDKACVTQFRPALEIIVDSGASALDILSAVNPSSPMDWLSLIILLDQIPRNSYRGAESKLVFGRFDPLAEEIALRAIKEGIPTQSPYFRYRMAYRTWFHMPLMHSENLAVHEQAVRVHEDIARDLNELLARDASTLTEEERKCHGVLSEQAEAVQTFLSNNSDFEKRHKVIIERFGRYPHRNEALGRVSTPEEIEYLNNGGETFGGDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCA2</accession>
    <name>A0A0G4PCA2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyoverdine biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S010g000375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PCA2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PCA2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007817">
        <property type="entry name" value="Isocyanide_synthase_DIT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37285">
        <property type="entry name" value="SPORE WALL MATURATION PROTEIN DIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37285:SF5">
        <property type="entry name" value="SPORE WALL MATURATION PROTEIN DIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05141">
        <property type="entry name" value="DIT1_PvcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL23937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="438" mass="49491" checksum="B513FE2EC7594955" modified="2015-09-16" version="1">MSYIKMLATAIVEVSAHLNIIPLDCITTTPKTRVSFPPKPHPVPPKPEVTTDTHPDAPGICPTLARLKAEEILNIVERYGSHERTTAAGEWLGRSSFTPRVQTHIAANRAIPMVLPAFPMKSNNRMDKVLGALPDLGDELGLARLVNLCRDIKAVYPPGAVVVIVTDGICYNDLTGISDEEVWEYGNRLRKIAVEKGYACIQFHRIMNMLGLYTGAQISKSDYVKLCGLSRAELRRRCGRPDFDVDKFLKSDEDYLRTYNGYDKFMKVDLKFSPVTRDCAGPKQYKKRIKTIAKAMIVRGVEYAELVRQIYPDSLRLSIHPSSGQTKLSCPLIPQKNSFSMSPWHCSIAVTTTGEFITAHQSTHRQKFDLIKKDSQPYFFRERSPLFDWDTSVDFEHHYGQKLVIRVQKQIDQELSDLDLDKMALLAIQQKSVSFVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PD86</accession>
    <name>A0A0G4PD86_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S011g000287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PD86"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL24293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="56" mass="6367" checksum="E267E3C8D5B4AA39" modified="2015-09-16" version="1">MQTAAVARPHLLHIRSSFFLLRPMVSNSSPDYKALFLRAEEGRKQAELRQKQATAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PE11</accession>
    <name>A0A0G4PE11_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S012g000146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PE11"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL24536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="172" mass="19679" checksum="5FE29EBBE331FADC" modified="2015-09-16" version="1">MSTVEHTGQSDIDALHLTFEINGLYILLSNRGDKSYTFHWCLYLHQNTTSGSIYHLLNGIDPTIWCFEHLPEQTVIYDKSLLGALKIGVLDPTLHAPFLERLRQIPIVDSVRFREKITCRVWLKESLFALDDEGYIMLTRSVDDIEAEARNLALRNKSLGRRTVVRSFGSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PEP4</accession>
    <name>A0A0G4PEP4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S013g000045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL24803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PEP4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PEP4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF67">
        <property type="entry name" value="AMIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
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    </dbReference>
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    </dbReference>
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            <end position="1059"/>
        </location>
    </feature>
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            <end position="83"/>
        </location>
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            <end position="218"/>
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        </location>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1059" mass="118644" checksum="34A238D7216A131A" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
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                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <comment type="catalytic activity">
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            <text>L-methionyl-[protein] + S-adenosyl-L-methionine = S-methyl-L-methionyl-[protein] + S-adenosyl-L-homocysteine</text>
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            <dbReference type="Rhea" id="RHEA-COMP:15592"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
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        </reaction>
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        </subcellularLocation>
    </comment>
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        <text evidence="9">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
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        <location>
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        </location>
    </feature>
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        </location>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
    <sequence length="428" mass="48745" checksum="575649CE0B2B2440" modified="2015-09-16" version="1">MSSYRESPGSFPAPDRTSLPKMFTNGDSRMRHLPPINSPPPPKRYKSESTPASDAGHSRYYSHSVASDRVRSRQPSSAMDLYTLIDRDPVDKDPRRNARFTSNGSVATQASHTSNTSQVSRSSPIIISDRKIPEKYPNHKENGRMYHGYRKGVYPLPCDEEEQDRLDIFHKLFTVARAEDGLIYAPHPPGSRILDLGCGTGIWSIEVANKFPNSFVVGVDLAPIQPANFPKNCDFYAPFDFEAPWTLGEDSWDIIHMQMGCGSVASWPSLYRRVFQHLRPGAWFEQVEIDFRPRVEDKDGEPGRAMASWYSTLKHATEATMRPLAHSSNDTIRNLQEAGFTEIDHQIVGLPMNPWHPDSHEQKVARWYNLAISESVQPLCLAPFSRVLSWSREQIDRIAFDVKQEAFDKKIKTYNLLHIYQARKPLEE</sequence>
</entry>
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            <taxon>Pezizomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Znf_CCHC"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL25000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="982" mass="111700" checksum="41F6BA7781940F0B" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PG86</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
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                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="39"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL25310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="399" mass="44387" checksum="67E42E52CA09371B" modified="2015-09-16" version="1">MGVMRLPRPTGIYVPNSPRTLTNEMISPPLSPEFSFDSETVTPSLLPALEYISSKLQQRMMHVTLLIGRGKPYPTGQPSDLMIIPIHTIEPQAWRVLERAIFKGSRKFSLGSSWTDAISRSQYERQANDHLVKQSILQNEVIFSQEGLTLLNMDRIYTFKRRMCILSTRPFSRDDEQSMSSCVRLLHRIVKDFSGRPFSKAFFHRVYEQLDVPDEQLTAVAVAYKNVHNEDAIILPVQAKAPAPAPAPAPAPAPVPAPALVPVPAPAPEPVLAKVEPIVPVKVAAKVQAKVQAKVQAKVQPKAAERVILKPKADPIPIRVKAERPREVKRSPIQTVRGRRQPPPSKMRGHNKRGPKTPLSASDVTPITRNEWNILVSQDIRVQPKVTKWVPSPTVLAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGA6</accession>
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            <fullName evidence="2">Cyclin-like F-box</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PCAMFM013_S014g000237</name>
    </gene>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="28"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL25341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="402" mass="46972" checksum="7B7FE5E8AD56D78C" modified="2015-09-16" version="1">MKSLTARVKSYLPRPHKAISSCSEIPCMTTLAGLPPELLLSISDFLPLVDLICFSLCNHRLLQLSQRQINRLPPRTKDDQLSILNRLERDFPKYFACEVCSRLHRYDGSESFGLSGLAHKRTCRLPCVRREKRFDPHWFDYSLILRTHFGVQYTANHLSFLQLKLAMRRFYYGPRSYQYRFSILYTAQICPRHLGLCIRMHDIVLLRTRDELIFRPGRRSDSNPLYTLEVCAHFGLLTITTPVVESLHDGEKASFAHTCYRCNTDSQIEIGEFESKITLVMTRWVNLGPCLTKEDLLWKTHVWFPGYPRARLDEDDSEDLLTRIPRLCFEEKAPQSFEDLQSGNLSYLRDQQYKNVMPFIAAGIDVWYMSYKDPSKKKGRGIEFDPYYAVRPYLEKIGLSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGP6</accession>
    <name>A0A0G4PGP6_PENC3</name>
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        <recommendedName>
            <fullName evidence="12">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="12">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S015g000079</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="12"/>
    <dbReference type="EMBL" id="HG793148">
        <property type="protein sequence ID" value="CRL25493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PGP6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PGP6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF134">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="310"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
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            <dbReference type="RuleBase" id="RU361115"/>
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</entry>
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    <accession>A0A0G4PGZ5</accession>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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    </evidence>
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    </evidence>
    <sequence length="1403" mass="158335" checksum="4A09097183D1C388" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PHW9</accession>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
            <dbReference type="EMBL" id="CRL25962.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
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        <property type="protein sequence ID" value="CRL25871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PI54"/>
    <dbReference type="STRING" id="1429867.A0A0G4PI54"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="34"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL25871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="648" mass="72688" checksum="883E56C5E17FB339" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PIL4</accession>
    <name>A0A0G4PIL4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S017g000248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793150">
        <property type="protein sequence ID" value="CRL26265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PIL4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PIL4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL26265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="440" mass="49794" checksum="72FFA58BA921B506" modified="2015-09-16" version="1">MAVGACYWSGNGSYSCTCRGQGQPDVDESSSTPCLECGHPLRNHFRIGLHPSGPNPSASRVFIPRTDVFIPRHKTVRRLANRIHEQRVVLARGIPASGKTFLARSLHTYLRGQGVKSIYIKSFPLSLEGGPSALDYLVEACHIQGFPTFGHSLLRDNFVFLIDDAHTTYNNSELWLILNSANQDCLSNVPGASFCMFGAFGTPDRGVMPHNMGSDLLVFNKRQRLVLKEGFDEDISLFYTRQEFDLHVEMHLQARGSDYEICFALKDIISDLTAGQPELVHAFMILCDMWYDAFFKDDEIDEIECDDDEISRFFEVRGLLEGSIAVILDFAGLPLSPDTFFPPEQEFEVLRQVQQVNQQNLSQGLLFNPHSEAMLSCLTKGWLHMEETQKGEFKCYFPTQFHKRLVEYLVGVQDLRYPTPPTLNRGELELMVAMRNMTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJF0</accession>
    <name>A0A0G4PJF0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase C14, caspase catalytic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S018g000157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJF0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJF0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL26464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="401" mass="44271" checksum="B477CF02EF02AD0C" modified="2015-09-16" version="1">MSEPSDPVSPTTSHHSAPISVTTPPSSFPSKAPLVHHLPALKAELNQVATARGNVYAKKMGIIIRWDGDNTGAEEDAITMSRVMDTFNIQCTHHILKTSDPIPGWTLTDKIRKMILDCCNSKLNSLFVVYYAGHGTIVDGNLYFAMGEKLVSWSKIRADLNSYEDTDAMRRIDVLGVLDCCYSGAATRAQNSRTFQVIAACGPKEGTNPRIGQTISFTMRLFRAVHHFKGQASASMTTAALFREIQRQKPRGAPNAVMETLSGTRPITLVFKDRTISSRIPRLSTHVNEKHVLVKLTLHGPSQARGHSQALGHRYVLESFKNAIQDLPANMKVEISDAYETDQSIFLIIGMSWEAWALWSMVAHLEFIGIILGPSLMSRRLIEVPVANENSRPLYGKSGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PK44</accession>
    <name>A0A0G4PK44_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Blue (Type 1) copper domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S019g000209</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PK44"/>
    <dbReference type="STRING" id="1429867.A0A0G4PK44"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000004">
        <property type="entry name" value="Acetylornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005685">
        <property type="entry name" value="PRK07483.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094:SF2">
        <property type="entry name" value="AMINOTRANSFERASE, CLASS III (AFU_ORTHOLOGUE AFUA_1G16810)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL26792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="453" mass="49208" checksum="D13276BF97DC3DF4" modified="2015-09-16" version="1">MTNETKTSAILHRDTRFVPKKAIGGKGCYIFLEDGTKFLDATGGAAVCCLGHGNEQVAQIIKDQMDQISYCHSAFFGTQVAEDLAKLLVDSTGGKLSKVFITSSGSEAVEAALKLARQYFLELPTPQTERTRFIARLPSYHGTTLGALSVGGHVQRREPFEPLLSKNVSHVSPCYAYRGKLDGESDADYVARLAAELDAEFQRVGPETVCAFVAEPVVGAALGCVPAVPGYFRAMKAVCEKYGALLILDEIMSGMGRCGTLHVWEQEGIVPDIQTIAKGLGGGYAPVSAVLINDSIVQTMDKGTGQFRHGQTYQGHPISCAAAFAVQKTIQEQSLVESVRTMGVYLEAQLKQRFESHPYVGDIRGKGLFWGLEFVKDKATKEPFDPKDRVSYRLQEKGLEPEHSVSLYCSSGTVDGIKGDHLILAPPYIVSKEEIDIIVNALDKVMKEVFSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKA2</accession>
    <name>A0A0G4PKA2_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphatidylinositol N-acetylglucosaminyltransferase GPI3 subunit</fullName>
            <ecNumber evidence="3">2.4.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GlcNAc-PI synthesis protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S019g000221</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalytic subunit in the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.198" evidence="3"/>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKA2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PKA2"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017176">
        <property type="term" value="F:phosphatidylinositol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03796">
        <property type="entry name" value="GT4_PIG-A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000053">
        <property type="entry name" value="Phosphatidylinositol N-acetylglucosaminyltransferase GPI3 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000026">
        <property type="entry name" value="Phosphatidylinositol N-acetylglucosaminyltransferase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039507">
        <property type="entry name" value="PIG-A/GPI3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013234">
        <property type="entry name" value="PIGA_GPI_anchor_biosynthesis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08288">
        <property type="entry name" value="PIGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="PIGA GPI anchor biosynthesis" evidence="11">
        <location>
            <begin position="45"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="10">
        <location>
            <begin position="217"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL26804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="488" mass="54688" checksum="DB8B54E016DDFF29" modified="2015-09-16" version="1">MPYNIAMVSDFFFPQSGMSRGIESHIYQLSSKLIDRGHKVIVITHAYKGRTGVRYLTNGLKIYHVPFFVIYRETTFPTVFSFFPIFRNIVIREEIDIVHGHASLSSFCGEAILHARTMGLRTVFTDHSLFGFADAASILTNKLLKFTLSDVDHAICVSHTCKENTVLRASLDPLMVSVIPNAVVAENFCPLSHTTHAPDQGLSSPADAPMSPRLIGPDDPITIVVISRLFYNKGTDLLIASIPRILASNPNTRFIIAGSGPKAIDLEQMLERNVLQDKVELLGSVRHEEVRDVMVRGDIYLHPSLTEAFGTVIVEAASCGLYVVCTRVGGIPEVLPQHMTTFAKPEEDDIVLATSKAIAALRSNKVRTDRFHDQVKMMYSWRDVAARTERVYEGIIGDISPEEFYGYYPGQGWEASGDRVRSFALIDRLKRYYGCGVWAGKLFCLCVVIDFLIYVFLEMWFPRANIDIARSWPKKPPASKTQTTRSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKN7</accession>
    <name>A0A0G4PKN7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Crotonase, core</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S020g000063</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793153">
        <property type="protein sequence ID" value="CRL26904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKN7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PKN7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF171">
        <property type="entry name" value="SD19268P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL26904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="276" mass="29375" checksum="4828805E4A54460D" modified="2015-09-16" version="1">MSILTTWTTQKTTKIAHLTITRPKKLNSLTTPLLTTLTSTLNQISQTPNLLAITLTGAGPKSFIGGADLKELSSLPDATAARKFITNVHETCTAIRTCPVPVIARINGFALGAGLEIAAACDLRVAGRGVVFGMPEVRLGIPSVVEAALLPGLIGWGRTRQLLLLGGTISATEALSWGLVERVVADEDLDGAVSEWVSEIGRNGPLAVRRQKALISRWEELSLEGGIEAGVDAFGECFVPGEDGGTEPGRMMGDFFREKEEGKDKARRIEAEDKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKZ6</accession>
    <name>A0A0G4PKZ6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Potassium channel, voltage dependent, Kv, tetramerisation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S019g000240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKZ6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PKZ6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18316">
        <property type="entry name" value="BTB_POZ_KCTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31758">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN YLR108C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31758:SF2">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN YLR108C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0407">Ion channel</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Potassium channel tetramerisation-type BTB" evidence="2">
        <location>
            <begin position="22"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL26823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="431" mass="48395" checksum="14562466F785FF90" modified="2015-09-16" version="1">MDMHTVSRSSKCNLPSEKVFSIQIGSEIFRLSGASIASDAPSYFSRFFEDQLLQNQDAANVRTLYIDRDPTTFREIARHLQGYYVRPQDGAQFVKLFADAQFYTLPRLMSQLFESECFIQIGDRHFQIPRDIFSGPGDSPNFFTLGFAAFFASPTAVFPGLDRQGLLRPPAIVPPSVPNRSADVFDELLHMLRGYPLHIRNEDHRAALLRDCRYFHLRGLEQKLIPHQITTNPFTHRLEIVIRLEDVRPSGIQFAFDTASGSPALGGMVTYTRPFVDESAADLVVEIGDETSLIHQGSMRADFLGLAKQRITSLLQTVGKKMNLPNSHPPLGQVLIKVRIDRETDLTVDGEQDPQHLMISRAQTGADAGGVPPAKRPRVDNTDDAPWVVRTGQWRLQVQRGSTGAYEVVLVAVKLDIYTSARVRNQSRKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PL95</accession>
    <name>A0A0G4PL95_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S021g000115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793154">
        <property type="protein sequence ID" value="CRL27200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PL95"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195564" evidence="1">
        <location>
            <begin position="28"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL27200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="74" mass="7999" checksum="6A1B37A1D5E15826" modified="2015-09-16" version="1">MMLRLLGYASLAHLHIILVLYPPIGLSVQVPPPICPLYVHSRKYVMTSGPNVGGARLCKVLAGLEIVLPAPGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-11-27" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PLA9</accession>
    <name>A0A0G4PLA9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Post-GPI attachment to proteins factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S021g000130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the lipid remodeling steps of GPI-anchor maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PGAP3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793154">
        <property type="protein sequence ID" value="CRL27215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PLA9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PLA9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007217">
        <property type="entry name" value="Per1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148">
        <property type="entry name" value="PER1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148:SF0">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04080">
        <property type="entry name" value="Per1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 7" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016480380" description="Post-GPI attachment to proteins factor 3" evidence="7">
        <location>
            <begin position="29"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL27215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="332" mass="38853" checksum="7E2C047BE5484532" modified="2015-09-16" version="1">MNLGVGRVNLYTLFAFVFLAFLIGRSNASLGDHLPDFKECVQVCKTENCQNGNSVLPLHHRLLLWTCPAECDYTCQHVVTDRRVSRDPPMISPVVQFHGKWPFRRLLGMQEPFSVLFSFFNFAAHWHGMSRVQESIPAWHSLRPYYMMFGYIGLASWTFSMIFHMRDFPLTEKLDYWAAGASVLYGLYLAVVRIFRLDLENTPYRPTLRRLWTAVCVLLYTLHVSYLTFWSWDYTYNMMANVVVGIIQNLMWTGFSIFRYQRHLKSWTAWPGMIVAWIIMAMSLELLDFPPWNGLIDAHSLWHLGTVVPAVWWYSFLIRDTQDDIAAHRLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PLV5</accession>
    <name>A0A0G4PLV5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ankyrin repeat-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S022g000072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793155">
        <property type="protein sequence ID" value="CRL27392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PLV5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PLV5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL27392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="146" mass="16382" checksum="8A9190D031EC1E27" modified="2015-09-16" version="1">MVCSKSNIKDLPNELLPWIVSHLEEQPKVRVDIKHKHGRTALYLTVFASRIEGRRRFEMPSTSLHHAATRLDTVSLQRLLTVPEIDPNVYVIGHSLISIAASRGYVSVVACLLNIGSVEINRRAFIDPPICQTAAHGHYNIVRLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PM77</accession>
    <name>A0A0G4PM77_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AP-1 complex subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S021g000198</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit APL4 and beta-type subunit APL2), a medium adaptin (mu-type subunit APM1) and a small adaptin (sigma-type subunit APS1). AP-1 interacts with clathrin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793154">
        <property type="protein sequence ID" value="CRL27283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PM77"/>
    <dbReference type="STRING" id="1429867.A0A0G4PM77"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016482">
        <property type="term" value="P:cytosolic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000030">
        <property type="entry name" value="AP-1 complex subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017107">
        <property type="entry name" value="AP1_complex_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037094">
        <property type="entry name" value="AP1_complex_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
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        <property type="entry name" value="FAD-bd"/>
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        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
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            <end position="333"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL27538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="420" mass="46506" checksum="9C945D7DB1FAA972" modified="2015-09-16" version="1">MVGQALTSVAIVGGGPGGLGTAIALSELPFLKVTLYEKNTEPREAGAGISLSTNAWRVLDLLGASDGVKGGSKSNTHQRNAYTGKVLNVTQHPENSAADSRGAIRARRTRLQSALLSRVPEGLIQFDKKVVSLENLSGQGVRLVFQDQTEAIADIVVGADGLHSVVRSVLLPDHRLHFTGNSAFRVLVPKSRLAHIPDITTTTSWWWGEAGHVYLSDVDDEEETQDPRFEITVRSYREPEVSGKAVFWGIPATNEKVGSRVEKFDQRIRDAVSAVTEGEWREFATFAGPRLDKITHWDKVALIGDASHPLSGAFGSGATFAMEDGWILARALEFTRFASRPARDALEIFEQIRAPYYAKMYQHLDEIRDQTQQLQAQEKDFDVFLQAKIDSFLYGDKDFIYQNDIKKVWDDYLVAEQTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PN39</accession>
    <name>A0A0G4PN39_PENC3</name>
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        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S023g000041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793156">
        <property type="protein sequence ID" value="CRL27583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PN39"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL27583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="113" mass="12333" checksum="87D119E7DDCFD2A2" modified="2015-09-16" version="1">MILPSLSPAVACSHDTLYFSTNTAQQARRDCNGGRSHDGSRANNNGNNNNNKGKRKLKTWLLTTPPTNALIHAREAHRQPTTKTGSVADVPSTPKKYPTMTRSLSAEEMKSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNP6</accession>
    <name>A0A0G4PNP6_PENC3</name>
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        <submittedName>
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the HSF family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1429867.A0A0G4PNP6"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000173">
        <property type="entry name" value="Heat shock transcription factor Hsf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="7">
        <location>
            <begin position="149"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="73"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="254"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="444"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="648"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="689"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="722"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="449"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="480"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="495"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="722"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL27980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="752" mass="81822" checksum="51C4C6F316495147" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNS3</accession>
    <name>A0A0G4PNS3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S025g000165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793158">
        <property type="protein sequence ID" value="CRL28107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PNS3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PNS3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL28107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="416" mass="44676" checksum="1B9A91AF80CDD152" modified="2015-09-16" version="1">MESDTRPRTRPSSSLPRQGWSRLLSPTHASPIVSAASPSHQPNQRRESVAEDTAAAYRTTAMRQINGSPRSAPRPARDNPSRRRSSTLATRPVLVRAYSGDAQDRSTRPSTMSARRFLSFSSSRTSAPARPSQSDVMFPTDKDFSIESILQAIEPDIRGTLDSIAEICGRSKLSLSNEYGSHIAPLGEICAPSGALGPVEEARPNEERRVDDSNTAIVEDEASPIDPTRDIHPFSFHRYLENLRHTASMLEQNGASGQTTQRQPHSPLSPAMASEVETVLAIVPETTASTPFTRQFASRPKHNGRDLLAKNAAAASGGQQSSQMATPAVVSEVHLEVIANDGSSTDPNILPQPALAGDGLPDTGRSSPEIIQSLLGWLKWTASIAGPESNPALESAEGRLRAMLDRSGNEAVPSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPB1</accession>
    <name>A0A0G4PPB1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
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</entry>
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</entry>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793160">
        <property type="protein sequence ID" value="CRL28396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQJ7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PQJ7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AUSG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL28396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="500" mass="56258" checksum="5704FF4F342768FE" modified="2015-09-16" version="1">MAVITELLNTPYVVQSVCIALVAVFITSVWPDIANGIPYRHIPLVGKTWWELTNKKARQRFTRSCRQLIAEGFAKGVNVFQIIGATSPIVVLHPKFVDEIKSNPDLSFDDSIKKAGYEAGNTCLTQALGSISLRLSKESGAILNEHLPPTDEWKPYHIAHKIPYMVARLSSLIFVGETISHDDEWIDVSVNYAIDAFMAMRDLREWPSILHPIVHWFLPSTQKLRTHLEMARSIISREIDRRALIRAGKLPADDPPREPDALDWYRETAKAQNNKTFDQSCAQVGLALAAIHTTSNLLTNVLYDLAAYPEYIQPLRDEIRAVAAEDGVLKKTSLLKLKLMDSVMKESQRTNPLSLTSMNRLALKQIVLSDGTVIPKGANMFVSMKILEDDTIYPNAATYDGYRFCNKRKQPGNEHKHQFVATTSEHFVFGHGVHACPGRFFAASETKIMLLHLLLKYDWKLQSGGRPPNIDNGVESITDPRVQILFRSRKSEVDLGFLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQN5</accession>
    <name>A0A0G4PQN5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S030g000002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793163">
        <property type="protein sequence ID" value="CRL28715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQN5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="710"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="674"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL28715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="823" mass="91579" checksum="1958048CA02114A3" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRD5</accession>
    <name>A0A0G4PRD5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="3">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S030g000010</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="3"/>
    <dbReference type="EMBL" id="HG793163">
        <property type="protein sequence ID" value="CRL28723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PRD5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PRD5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000031">
        <property type="entry name" value="Probable PRS4-ribose-phosphate pyrophosphokinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000005">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002320">
        <property type="entry name" value="PRK01259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF32">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="12">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL28723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="320" mass="34847" checksum="275ABAAA2E9E5068" modified="2015-09-16" version="1">MSTNSIKLLTGNSHPELANLVADRLGIELTKIMVLQYSNQETSVTIGESVRDEDVFILQSTKPNDINDGLMELLIMINACKTASARRITAVIPNFPYARQDKKDKSRAPITAKLMANMLQTAGCNHVITMDLHASQIQGFFNVPVDNLYAEPSMLKYIRENLDVSNCVIVSPDAGGAKRATAIADRLDLQFALIHKERARPNEVSRMVLVGNVKDKVAIIVDDMADTCGTLAKAAETVMQHGATEVNAIVVHGILSGKAIENLNGSCLKRIIVSNTVPLGDKQEQCDKIHTIDISPTLAEACRRTHNGESVSFLFSHTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRK0</accession>
    <name>A0A0G4PRK0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S030g000080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793163">
        <property type="protein sequence ID" value="CRL28793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PRK0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PRK0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL28793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="187" mass="21971" checksum="2480C5D116EB6093" modified="2015-09-16" version="1">MPKDNKDIEDLILKAIDSLSKQSTPEYYIRRRRDLNVEKASALDKTMVERWFQDYQRVVTKHGICQQDIYNFDETGFQIGVRQDQFIITREPKRSYSIDLSQNTEFSTPKTAKRIRRISSRLSQYDPTIQRFKDGLEKLIKGAKAQAVLALQLQREFDRTQAIIGARHARYNNYRRHIQITGIISST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PS48</accession>
    <name>A0A0G4PS48_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aspartate aminotransferase</fullName>
            <ecNumber evidence="8">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S032g000004</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="8"/>
    <dbReference type="EMBL" id="HG793165">
        <property type="protein sequence ID" value="CRL28968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PS48"/>
    <dbReference type="STRING" id="1429867.A0A0G4PS48"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006533">
        <property type="term" value="P:L-aspartate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000026">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000181">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF22">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 10" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="9">
        <location>
            <begin position="57"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL28968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="429" mass="46650" checksum="61018A7D85DAD6A4" modified="2015-09-16" version="1">MLSTLRVASRSAASREANMRTVVIGARHASAWANVPQGPPDAILGITEAFKADSFKEKINLGVGAYRDDKGKPYVLPSVRTAEDKVVASRLDKEYAGITGIPAFTTAAAELAYGADSSAIKDNRLVITQTISGTGALRIGGAFLKQFYPGAKKIYLPNPSWANHKAVFSDSGLEVAQYSYYNKDTIGLDFEGLIADIKAAPEGSIILLHACAHNPTGVDPTQAQWRQISDVMKQKGHFAFFDMAYQGFASGNADQDAFAPRHFVKEGHNIALCQSFAKNMGLYGERVGAFSLVCENAEEKKRVDSQIKILIRPFYSNPPVHGARIASTIMNDPALNKQWLGEVEGMASRIIEMRSLLRTNLEKLGSKHDWSHITSQIGMFAYTGLKPEQMDSLAKEHSVYATKDGRISVAGITSANVERLAESIFKVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PT54</accession>
    <name>A0A0G4PT54_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">glucose oxidase</fullName>
            <ecNumber evidence="14">1.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PCAMFM013_S037g000064</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>beta-D-glucose + O2 = D-glucono-1,5-lactone + H2O2</text>
            <dbReference type="Rhea" id="RHEA:11428"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16217"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.1.3.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:11429"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
            <location evidence="4">Extracellular space</location>
            <location evidence="4">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.4" evidence="14"/>
    <dbReference type="EMBL" id="HG793170">
        <property type="protein sequence ID" value="CRL29577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PT54"/>
    <dbReference type="STRING" id="1429867.A0A0G4PT54"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046562">
        <property type="term" value="F:beta-D-glucose oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.450.10">
        <property type="entry name" value="Glucose Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027424">
        <property type="entry name" value="Glucose_Oxidase_domain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GMC_OXRED_1"/>
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    </dbReference>
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        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="11 16 17" id="KW-0274">FAD</keyword>
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            <end position="592"/>
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            <begin position="36"/>
            <end position="37"/>
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        <ligand>
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        </ligand>
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        <location>
            <position position="110"/>
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        <ligand>
            <name>FAD</name>
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        </ligand>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL29577.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="592" mass="64003" checksum="9E4F0CB0966EA60F" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
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                <person name="Debuchy R."/>
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                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL29468.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="143" mass="16444" checksum="1BE22F2B11A262F8" modified="2015-09-16" version="1">MRSVPDPPQNLLDRVNAAEHSPSRDSNVKFIFHVIHSEAEDLSAFEEIDLEDEEVESEDGDSQRQHRFDTLEEANKAALALFRSEYEDFYDQEEDMSNWYEEGTSEVMMNDVIWQVVDGMLSLQAHNAEEEIVGQIYVSASKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PTN7</accession>
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        <lineage>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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                <person name="Debuchy R."/>
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                <person name="Bensimon A."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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            <end position="83"/>
        </location>
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            <dbReference type="EMBL" id="CRL29513.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="172" mass="19285" checksum="434CB29189A7F974" modified="2015-09-16" version="1">MKNSTLSMPIARSCLTRPTEIVGNLQQNLGKPQILYGSQALKRLNWKGNSESVLRFNESKQKAQDLEKRLDEATLDRENYVSREEHEKAPRDLLGPSSSVIKMIESNINASQNVYMSIFMPPSDVAQGPWADESDQFAMLNHPVALDDMEPMLSTSDPLAGLPDFDMYEALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PTY0</accession>
    <name>A0A0G4PTY0_PENC3</name>
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        <submittedName>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PTY0"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047622">
        <property type="entry name" value="GPR1_FUN34_YAAH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038013">
        <property type="entry name" value="AceTr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01114">
        <property type="entry name" value="GPR1_FUN34_YAAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL29828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="280" mass="30035" checksum="3E87D03D900E67E8" modified="2015-09-16" version="1">MGHAIDTTEVQQTKAASSHHLEPSTQDNTGSSVVSQLSNDYSSLPSNTPGPCLSCRQGHQSSPVDVQKFANPAPLGLCAFALTCFISSCISLNVRGIQAAGVSVSLALNYGGIAQVLAGMWEMAIGNTFSATSFCSYGAYWITFSLISTFDTPNATKDTPDPVCQNETLMGLFMLAWFIFTTLMLLCTLKSSLAMFSLFFFLDMNYLLLGIAHIQCSSHGAIPIAVQKAGGVFGMLAAFSAWYNAFAGIHNLNNGFFIVPLGHFPWSPAGHIYRDKAKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PTY2</accession>
    <name>A0A0G4PTY2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S038g000014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793171">
        <property type="protein sequence ID" value="CRL29611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PTY2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL29611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="86" mass="9656" checksum="583E6C92FFF32016" modified="2015-09-16" version="1">MSTPTRIIRVENNPQKIRESGLLQQYGYEIVTKEGETYLSPNQTDGGRDNQTELLTQMVDLGYNLSISGISGERVDCRYVGNRTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PV43</accession>
    <name>A0A0G4PV43_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S043g000002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793176">
        <property type="protein sequence ID" value="CRL30007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PV43"/>
    <dbReference type="STRING" id="1429867.A0A0G4PV43"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL30007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="396" mass="45389" checksum="B7158F772734A49B" modified="2015-09-16" version="1">MNRLKIFQHFRNMFYSQSDPVYIGLKSGLDVESDEDLTDIKPSTSTLLMRAFSLNAWSFVTFILLVTLIGKWSQWGCNCEDRITMWAMPDSDMPEPLLKFEKRRFTNAIRDDPGGNLYSSISPNELQYAGLPSSKIDENWNELIAGRYFRLEDSEVSLLNRDPELPALTAMPSNERISKEGFYGGPDVLHSLHCLNAIRKHLDMEYYADSMTLPLEYRRIHIDHCVDHLRQALLCHGDLTPVTMKPVAANTSLPHSVTFYLGQTEREHTCRSTEAIRDWVTTRGKRTGPGAWYKHKVVTLVAFDPKGVFNGVNKVNLDACLRVRRIPTAARKWITSFRSGHHASIRFDYFRIEMTPLVNAGLGQSSHICILQLRLSRSTRHLSRREQQSIIFIVDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVF9</accession>
    <name>A0A0G4PVF9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S052g000037</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="HG793185">
        <property type="protein sequence ID" value="CRL30480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PVF9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PVF9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000125">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF131">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 8" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005118127" description="Carboxypeptidase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="517"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="531"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="541"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL30480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="559" mass="61836" checksum="319E38F39D48F2C0" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVX8</accession>
    <name>A0A0G4PVX8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S056g000034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793189">
        <property type="protein sequence ID" value="CRL30661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PVX8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="117" mass="13012" checksum="238FB22D0AB91EDC" modified="2015-09-16" version="1">MSDYRQRSPVDPAFLSDNNNYDPISIDDDSDTDTIRMDSPEFWSGINAEKAPVQNAPHSVMLTKSTPVSTFLKYPSCEKLDCTCPVQYPASTQDQLAEENSETNEIESSALKAESEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PWC8</accession>
    <name>A0A0G4PWC8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclin-like F-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S056g000020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793189">
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        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="503"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL30647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="634" mass="71165" checksum="36FD6B337F4EA21C" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PWF7</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356:SF2">
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL30462.1"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="678" mass="74992" checksum="6C4D84C52B1DFBC7" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PXW3</accession>
    <name>A0A0G4PXW3_PENC3</name>
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        <submittedName>
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    </protein>
    <gene>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
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    </reference>
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    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL31011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="90" mass="9812" checksum="C4E34F77BFF848B3" modified="2015-09-16" version="1">MFIACFSARFLRFLDRSRASGDVRCRTLYSLKRRNGVKDKPQISRQASSLSLVPTRARVSLVSGQLRATARPQFAAGLAVGGGPSIRKCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PY41</accession>
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    <protein>
        <submittedName>
            <fullName evidence="8">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S075g000005</name>
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    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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            <dbReference type="PubMed" id="24407037"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF38">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="44"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL31101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="466" mass="51195" checksum="0D62F4D97F52960A" modified="2015-09-16" version="1">MDRNFESQLKDISSHEIEDVNISESVSFSPEEEKALVRKIDLTLLPTIWVMYLLSYLDRTNIGNAKISGMQVDLDLSSNEYSIALVVFFVGYVVFEVPSNLALGRSRPSIFLPSIMILWGVLTCVMAVINDFTHLVVLRVILGCVEAGFAPGVILLLSSWYKQTEQSKRFGVFISAAVLSGAFGGLIAAGIVDGLEGVHGIRGWRWLFIIEGAATVGFAIISLFILPDFPGTSRRLSERERHIAVARLAAQNVTATTEDTEHLSNWDACKVACRDLRTWTFVIGYMVIVGSSTLTYFYPTLVQGLFGDASTKKINLLTVPIYGVAFIATGVTSYFSDKVPNWRGVIIASWLTFSLVCSIIVCAVYNFTARYVLLVLMASGLWATNGGTLAYASSAFGGMHPQARGVALAMVNALGNLAQIYGSYLFPEKDGPKYIKGFSVISAMLAVGVIDFLFLHIWFRCRQRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PY60</accession>
    <name>A0A0G4PY60_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S077g000008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793209">
        <property type="protein sequence ID" value="CRL31127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PY60"/>
    <dbReference type="STRING" id="1429867.A0A0G4PY60"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38846">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38846:SF1">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL31127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="192" mass="22339" checksum="935C57F72F0212AA" modified="2015-09-16" version="1">MTYQQQQERDEIDHFFAQYLGFSYQREQPVHVEFYRMCDVFGWQRQRNGELPVAREEAWGLFRIAIVQAFNSTFGEDVNNLASWKRICGCLGISPVPENLHEARRAVLRTHVNLVDLLESMRAGAPAECFATEEDLRRYTISEGKFFPKEEAYEGGLLRFLLREILHDYEGSRSKNHPRKSNRGGGNHGVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PY93</accession>
    <name>A0A0G4PY93_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidoglycan-binding lysin domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S3Jg000069</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793312">
        <property type="protein sequence ID" value="CRL31458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PY93"/>
    <dbReference type="STRING" id="1429867.A0A0G4PY93"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF18">
        <property type="entry name" value="LYSM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002568497" evidence="3">
        <location>
            <begin position="19"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="30"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="111"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="179"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL31458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="227" mass="24463" checksum="784655C108E8C48E" modified="2015-09-16" version="1">MHFPQLLVAGLVPAVASARALSRRAVDCSFTTSPSSGDKCDSFASSWGLTVDDLKAMNPGISCPNLDTSKFYCVIGTVTGEPEPTTTTTTTTAPTVTNEPAMPGIVDDCDGFYKVSPGDECDTIATEHGISKAQFLEWNTSVNDQCSNLWLDYYVCVHVPGAATGPQPQMPGIISSCQKFYKVKSGDSCYTILQESGTDLSNFRKWNTKIDASCSNLWVDYYVCVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PZ91</accession>
    <name>A0A0G4PZ91_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S3Jg000086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793312">
        <property type="protein sequence ID" value="CRL31475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PZ91"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL31475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="355" mass="39516" checksum="214B22C413239D4C" modified="2015-09-16" version="1">MITVNQHQHSRALNMYATPSNSESTWYGHGHSHNEASPSPASNSASCQHNPYPVDAESDTNGLASKIDNGDRGRIMVYWKTLSPGQLPYVMLDFSFNTPTAQVGAYSIRTGQVMTSGHQLISQNPGKAIETKVSPDGRDQISDECCISCMILLVLLFSNTSPTHRITAVENEVERPVGTLMATIPNIHRPSLDPTAMLSHLLAQLQSKQALQRKRDNYKTIFPAKQSRVPLVNLLGTGQILTKIETLKRRGWPKLKRLSRAVYRNSKRISRLRAHLSFLQAELEELTSRNGSSKAVVCKQEMTKNELSPRRICLIRSLLVQHYLEKCSEGPVDGNRVNIPGLTALVIDRFPSLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NSN4</accession>
    <name>A0A0G4NSN4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S001g000002</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NSN4"/>
    <dbReference type="STRING" id="1429867.A0A0G4NSN4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036286">
        <property type="term" value="C:eisosome filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000005">
        <property type="entry name" value="Sphingolipid long chain base-responsive pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028245">
        <property type="entry name" value="PIL1/LSP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962:SF1">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13805">
        <property type="entry name" value="Pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="274"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="332"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL17042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="346" mass="38814" checksum="F7E7222A12E26FD3" modified="2015-09-16" version="1">MHRTYSMRQSRVPTASQIESPPPPLSTTKTGRWLGKGGIGHAFRKNAAGAFGPDLAKKLSQLVKMEKNAMRSMELVARERMEVAQQLSIWGEACDEDVSDVTDKLGVLIYEIGELEDMFVDRYDQYRVTIKSIRNIEASVQPSRDRKQKITDEIAKLKYKDPNSPRIVVLEQELVRAEAESLVAEAQLSNITREKVKAAFQYQFDALREHCEKVAIVAGYGKHLLDLIDDTPVTPGETRHAYDGYDASKAIIQDCEDALTNWVSSKAVVKSSLSQRSRTLSQRHRSNLSKNREGVDLSGQDQPLAGDRDSWLPADQHPNYEDGDDGVSTIEGELRGREEEREPITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NT62</accession>
    <name>A0A0G4NT62_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S001g000211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NT62"/>
    <dbReference type="STRING" id="1429867.A0A0G4NT62"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL17251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="348" mass="39284" checksum="EC7F03EC745CF361" modified="2015-09-16" version="1">MSNRSDIPCTEEMTEYYGGIPAHWPTIPATPLIGVTSPYCTESLAPNSLLTPISLPDSSFHPSPAISHHSQGYHAQEYHYSLNDPLSAPLGLGISAPFPSNFPQSSAPDPAYLYAPDPSVLQHGVAQTPSQPSQGPPPAKRARLPSSETPAREQPSNTPVSIAPNPEGVLRMQQDRQHIQPTSHILPRIRAPGRGRRDPQAEDEDAFVEELRDRHTAWKVVRQEFQERFKKDASEARLQMRLHRRYRERMVRWEESDIKLLIDAHGIWARDKFHYLSDKMKELGGTRLYSPDQCRTQLRLLDAKKQHRDRESESPSAMSDPAPMTPTVSRKRPRAQSLESDIDEEATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NTI9</accession>
    <name>A0A0G4NTI9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Acyl carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCAMFM013_S001g000293</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NTI9"/>
    <dbReference type="STRING" id="1429867.A0A0G4NTI9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099128">
        <property type="term" value="C:mitochondrial [2Fe-2S] assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000035">
        <property type="term" value="F:acyl binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000003">
        <property type="entry name" value="Acyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002148">
        <property type="entry name" value="PRK00982.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="ACYL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863:SF28">
        <property type="entry name" value="ACYL CARRIER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Carrier" evidence="15">
        <location>
            <begin position="58"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CRL17333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="137" mass="14935" checksum="58237B8E9232185A" modified="2015-09-16" version="1">MFRSAIVRSLKASAPRVIKTPAPFHIRSSPIAAQVPQFTPCFAQSVRLYSAPAGLSKTEAEGRIVNLLKNFDKVSDASKINGASHFSNDLGLDSLDTVEVVMAIEEEFSIEIPDKEADQIHSVEKAVEYILAQPDAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NU74</accession>
    <name>A0A0G4NU74_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">2,3-bisphosphoglycerate-independent phosphoglycerate mutase</fullName>
            <ecNumber evidence="6">5.4.2.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cofactor-independent phosphoglycerate mutase homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PCAMFM013_S001g000596</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BPG-independent phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="6"/>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NU74"/>
    <dbReference type="STRING" id="1429867.A0A0G4NU74"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006007">
        <property type="term" value="P:glucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16010">
        <property type="entry name" value="iPGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1450.10:FF:000001">
        <property type="entry name" value="2,3-bisphosphoglycerate-independent phosphoglycerate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000001">
        <property type="entry name" value="2,3-bisphosphoglycerate-independent phosphoglycerate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
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            <end position="503"/>
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            <end position="302"/>
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        <location>
            <position position="12"/>
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            <dbReference type="ChEBI" id="CHEBI:29035"/>
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        </source>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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    </evidence>
    <sequence length="529" mass="59246" checksum="C021C75BCB442073" modified="2015-09-16" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Dupont J."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </location>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
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        </lineage>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
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            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:amino acid catabolic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:D-galactonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03325">
        <property type="entry name" value="D-galactonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023592">
        <property type="entry name" value="Galactonate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010624">
        <property type="entry name" value="PRK14017.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080:SF2">
        <property type="entry name" value="D-GALACTONATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="D-GALACTONATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00003">
        <property type="entry name" value="D-galactonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00179">
        <property type="entry name" value="mandelate_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00908">
        <property type="entry name" value="MR_MLE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="5">
        <location>
            <begin position="126"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL18009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="383" mass="42708" checksum="2A4E7ABE2B0203E7" modified="2015-09-16" version="1">MAKIKSIEYFRVKPRWLFVKVTDEEGRFGWGEGTLEGHSLAVEGALDEIITRIVGYEADDIQHIWQTVWRLGFYRGGPVFMSALSGIDIALWDLKGRKLGVPVHELLGGKVRQKVQVYAWIGGDRPSDVEAAAKERIAQGLKCVKMNATEDVNWLDSPAVLQSCVERLKQVKALGLDAGLDFHGRLHRPMAKQLAKALEPYHPLFIEEPLLCEHPEAIKQLSEQTTIPIAFGERLYSRWDIKRFLEDSSVDVLQPDIAHAGGISETLRIANMAEAYDVAIAPHCPLGPIALAASLQVAVSIPNFVIQEMSLGMHYNVEAGDIDLNSYLVDKTVFDIKEGYVAAPSKPGLGIDIDEDLVRKISKETEPWQPKEFYGPDGSIREW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-11-27" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NW71</accession>
    <name>A0A0G4NW71_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alcohol acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S002g000109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NW71"/>
    <dbReference type="STRING" id="1429867.A0A0G4NW71"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052058">
        <property type="entry name" value="Alcohol_O-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010828">
        <property type="entry name" value="Atf2/Sli1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037:SF1">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07247">
        <property type="entry name" value="AATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL18239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="463" mass="51483" checksum="C53DD771A67BB9DA" modified="2015-09-16" version="1">MENLEILRPVGRLEQYSTSRHQVGFYLNVAVSATYFLPDSFVLPIKDYVYQACEAAIAQHPSLSAIVADDHTQEPYFVRLPEIDLDQVVSFQDRKPGLLAAEADGEPTPDLDLQTLLATQHNTPFKAPNPFWRVCVLLDIEDERQFTAAFVYHHAIGDGTSGKAFHQTFLRALGALDSSNQTKSIIKSPQLPLLPNIELVHPMSLSLLYLAKKIFQAKIYSRRPTGLWTGSKVLVPSQTRLRLVPFSKLLVAAIRDRCRQEGTTITALLQTIVARSIFAHIPPEFTQLACTGALSSRRWLPDIITDESMGVWVQDYEETYSRETVAPSDGSFPWEEARRSRKTIQSVLKMEGKNARTSLLQFVDDFQEELCLSKVGKDRDKSFEVSNVGVLDPQTNPDLPSIKGMVFSQSASVMGNAIEVSVVTGGDGCLVLAVSRQQGVVEADLVNEVVESIKQELYSIEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWJ1</accession>
    <name>A0A0G4NWJ1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="6">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S002g000189</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="6"/>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWJ1"/>
    <dbReference type="STRING" id="1429867.A0A0G4NWJ1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000005">
        <property type="entry name" value="Phospho-2-dehydro-3-deoxyheptonate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DAHP_synth_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009395">
        <property type="entry name" value="PRK12755.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE DAHP SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225:SF18">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, PHENYLALANINE-INHIBITED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
        <property type="entry name" value="DAHP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP synthetase I/KDSA" evidence="7">
        <location>
            <begin position="56"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL18319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="372" mass="40567" checksum="20D25DF37651796A" modified="2015-09-16" version="1">MSFFIDNPNVGNHSHLEDSRILGYNPLTPPNLLQHEIALTEKSRQTVLDGRNEAVEIVHGTDTKRQRLMVVIGPCSIHDPEMALEYCDRLLKMKEKYADELLIVMRSYLEKPRTTVGWKGLINDPDIDNSFQINKGLRVSRQLFVDLTNKGMPIASEMLDTISPQFLADCLSVGAVGARTTESQVHRELSSGLSFPVGFKNGTDGSLDVAVDAIGSVKHPHHFLSVTKPGVVSIVGTVGNPDCFVILRGGKKGPNYDAASIADAKSKLSAKGMRPRLMVDCSHGNSEKNHKNQPKVAAVLAEQIAAGEDAIMGVMIESNINEGNQKVPAEGKAGLKYGVSITDACINWEDTESVLENLAQSVRARREKSETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXA1</accession>
    <name>A0A0G4NXA1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Iron-sulfur cluster biogenesis chaperone, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S002g000434</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for the assembly of iron-sulfur (Fe/S) clusters in mitochondria. Assisted by the DnaJ-like co-chaperone jac1 and the nucleotide exchange factor mge1, it mediates ATP-dependent Fe-S cluster transfer from the scaffold proteins isu1/isu2 to grx5.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NXA1"/>
    <dbReference type="STRING" id="1429867.A0A0G4NXA1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11733">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000020">
        <property type="entry name" value="Chaperone protein HscA homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000003">
        <property type="entry name" value="Heat shock protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000007">
        <property type="entry name" value="Heat shock protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000004">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003520">
        <property type="entry name" value="PRK05183.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0346">Stress response</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="637"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="571"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="650"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL18564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="667" mass="72429" checksum="DD8D7464740FC648" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NY43</accession>
    <name>A0A0G4NY43_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S002g000846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NY43"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL18976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="60" mass="6524" checksum="027C2E5F51017702" modified="2015-09-16" version="1">MMQSAICTEVVRELCCASTLRTLTKVPLKTKAENWGQAKHAYSGVSQHSHPLRIGDVSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NY60</accession>
    <name>A0A0G4NY60_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S002g000784</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NY60"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL18914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="31" mass="3693" checksum="40E7AAD5683C93CD" modified="2015-09-16" version="1">MTPKPHNYQQKCRVRSSPYGVWSIKYLLRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYC1</accession>
    <name>A0A0G4NYC1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S002g000962</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL19092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NYC1"/>
    <dbReference type="STRING" id="1429867.A0A0G4NYC1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF7">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE (AFU_ORTHOLOGUE AFUA_2G00830)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL19092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="290" mass="31960" checksum="74F741A8E2EA5C27" modified="2015-09-16" version="1">MESGLPPTTFRKGATALITGAASGIGLATAQRCYSHGMNLVLIDNNAAALSQTTAKFIADGRNTTTTTSHILDVSSFDEWQQLVPKIESQFPDGIDFLMLNAGAGISPNGGKGMWEDPTYFERTFAINTMGYTNGIVALLKMVTRNEDVARAIVMTGSKQGITNPPSNPAYNASKAAVRSIAEHLSFDLDKAAPNVSVHLLIPGWTYTGFNAGYFKEKPAGAWTSEQVVDFMVEKMKEKKFYILCPDNEVSEELDRKRILWSTGDILENRPPLSRWREEWKEEAKREIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYW1</accession>
    <name>A0A0G4NYW1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S003g000066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NYW1"/>
    <dbReference type="STRING" id="1429867.A0A0G4NYW1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="56"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL19275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="533" mass="61932" checksum="43ED8058C55C4305" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZ32</accession>
    <name>A0A0G4NZ32_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S003g000080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZ32"/>
    <dbReference type="STRING" id="1429867.A0A0G4NZ32"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012535">
        <property type="entry name" value="Cell_div_Cdc14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34065">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34065:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08045">
        <property type="entry name" value="CDC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL19289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="286" mass="31906" checksum="3725062C41F0B601" modified="2015-09-16" version="1">MEALLAHSFDYLSSYEPSKIRKGLRQVEGLLAQICLSKPKPVLDRRSRSPETQPVPKTLSELRDDPAFREFSKLQESFQWNIAMRLVSCLEHLLGRGSNGTNDMLIVCTLDLIQGALLLHRGSRTLFAREIYMNLLLDLLDPINCPAVQSATLLTLVTALLDCPSNTRTFEDLDGLLTVTSLFKQRATSREVKLKLVEFLYFYLMPEAMTPAPMSPPPGLQRSPSKLSSAQFSRSAHSAAANAASKTNRDTRTTDEKQALLGRYLNNVEDLVEDLKETAPFGATVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZP4</accession>
    <name>A0A0G4NZP4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Endopolyphosphatase</fullName>
            <ecNumber evidence="3 12">3.6.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCAMFM013_S003g000337</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the hydrolysis of inorganic polyphosphate (polyP) chains of many hundreds of phosphate residues into shorter lengths.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>[phosphate](n+1) + n H2O = (n+1) phosphate + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22452"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the endopolyphosphatase PPN1 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.10" evidence="3 12"/>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZP4"/>
    <dbReference type="STRING" id="1429867.A0A0G4NZP4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006798">
        <property type="term" value="P:polyphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000082">
        <property type="entry name" value="Endopolyphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012358">
        <property type="entry name" value="EndopolyPtase_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF55">
        <property type="entry name" value="ENDOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027093">
        <property type="entry name" value="EndopolyPtase_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195279" description="Endopolyphosphatase" evidence="14">
        <location>
            <begin position="18"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="15">
        <location>
            <begin position="48"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="469"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="484"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="501"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR027093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CRL19546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="628" mass="71201" checksum="12B1225E6309CAA5" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZT0</accession>
    <name>A0A0G4NZT0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylose isomerase-like, TIM barrel domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S003g000366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZT0"/>
    <dbReference type="STRING" id="1429867.A0A0G4NZT0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050312">
        <property type="entry name" value="IolE/XylAMocC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110">
        <property type="entry name" value="HYDROXYPYRUVATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110:SF21">
        <property type="entry name" value="XYLOSE ISOMERASE-LIKE TIM BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="1">
        <location>
            <begin position="27"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL19575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="361" mass="40498" checksum="FBFBB32761E686DD" modified="2015-09-16" version="1">MAFNRPGIASMSLGRPWVHDLPGKLMQAADHGFKGIELFFDDLDCYAQRVFDGDHHAAARSTRLMCKRLGLTIICLQPFSMYEGLIDRAESDRLINEKLPKWFTLARALGTDMIQVPSNFLGPDPKTGAARTTGDRTVIVRDLQRLADLGAGAGFRFVYEALCWGDHIDTWEASWEVVRDVDRRNFGLCLDSFNIAGRVYADPASPSGRTPNAAADLAASLERLRTANIDPAKIFYVQLVDGERLSAPLDEKHPFHVAGQPVRMNWSRNARLFPLEESRGGYLPIVDIARVFFEDIGFRGWVSLELFSRTLGDTDPFVPADHARRGIDSYNKMARILRWDEPTDTVSVPMPVPESPVQHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZX6</accession>
    <name>A0A0G4NZX6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S003g000355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZX6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL19564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="113" mass="12740" checksum="4AE37263016F44A3" modified="2015-09-16" version="1">MSIEDMGIVKCGEHRRAHSLTGTHLSQWVSSRTSLVSPPLPHGTVHESEWESLVAESTQFPRLRITEESVRSWYTGIVALRQDLDDRVQEALNDSEIGQAIGEFLRSHIEGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0B9</accession>
    <name>A0A0G4P0B9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Berberine/berberine-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S003g000567</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P0B9"/>
    <dbReference type="STRING" id="1429867.A0A0G4P0B9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195287" evidence="6">
        <location>
            <begin position="22"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="122"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL19776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="592" mass="66208" checksum="CF1059168996ED83" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2P3</accession>
    <name>A0A0G4P2P3_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoserine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">O-phosphoserine phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S004g000531</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="4"/>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P2P3"/>
    <dbReference type="STRING" id="1429867.A0A0G4P2P3"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07500">
        <property type="entry name" value="HAD_PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000143">
        <property type="entry name" value="Phosphoserine phosphatase serb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050582">
        <property type="entry name" value="HAD-like_SerB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004469">
        <property type="entry name" value="PSP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00338">
        <property type="entry name" value="serB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344:SF2">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01137">
        <property type="entry name" value="C1.6.1:_Phosphoserine_Phosphat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01136">
        <property type="entry name" value="C1.6:_Phosphoserine_Phosphatas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00029">
        <property type="entry name" value="phosphoserine_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="102"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR604469-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL20590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="467" mass="51738" checksum="E47340BDC73BC510" modified="2015-09-16" version="1">MADSTRTTRPSLGQMRSSSFLQDHQQYKPMAPINSINQTIGEVLAHQVDDNLVLSSNPIKPDPERVTDSGIIHSIFNHHANPLPTGTSQIVATIYYKSNNPVHPHFHPDSGPQNAPGDKLPTPKVPEGSAPTEDMDKFPREPPAPEPEPLDHLYGPYVSQLCLTNFLQILETLPTPYQRMNTSHRCLDRDEHPRVVEVTFSPPPNPEYLSFPDLRKHESIWRFEREWNVEVVLQKESVFRRHKRLAVFDMDSTLIDNECIDEIAKFIGVEKEVSAITERAMNGELDFTASLKERVGLLNGVSSDVFEKLKSVLKIAKGARELCRALKTLGYKIAVVSGGFQPLAEWLAEQLGIDIAIANHLEIDEATQTLTGKLVPSYPIVDAAHKRTLLKSIAAENGIPLSQTLAVGDGANDLLMLHAAGLGVAWRAKSKVQLEAPVRINGESLVDVLYLLGMDNEDIAELTSDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2Q9</accession>
    <name>A0A0G4P2Q9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S004g000546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P2Q9"/>
    <dbReference type="STRING" id="1429867.A0A0G4P2Q9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL20605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="493" mass="56076" checksum="E9528010DE099A0A" modified="2015-09-16" version="1">MVILWYCCGCDFGPHNSSLYDACLQCGKVRCARCTDEGLNETPQTSSTQETTRQTPNYSTGRRKRSQRQTTQAKSPSDTVSSTRNTSIPKRLLRELKPKLQPPHQQESSTSPGALPNNLKDDIQSQPFSAPQASTSYIIYSSSLGSILVDWVYEQSSSGVYSSNEVRALEDVLIELKNTQPGLISMKTEDELSFWNNLKGKVETIIGLLAWSPFQPYMAPLTQDQVRLFWECPCGDTRWAAVPRSFGLKIEDAYRTNAAQATQKNMSGSGRSLPEIGTSSQISGVRTRTQTGEPVSESGLPRSTVECQSSESPQNTGSQLHAFLVLLNSSIFGSAHYLVQTSVHNMSDLDFFAWIRNSYHSNRGFLAIWFGLYRYSHCEFFRFRRFDGYEYAPLLPEYPNEDQPSYHFAPKPMRPRPPMASHEFDHWFYKESWSRAARRLLSTEGHRRKNKRMRFFLGSRSVIEEKIPKRETALKEGVPASEDFWGLWIDLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2R7</accession>
    <name>A0A0G4P2R7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S004g000479</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P2R7"/>
    <dbReference type="STRING" id="1429867.A0A0G4P2R7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL20538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="248" mass="25809" checksum="0836D53256315CD8" modified="2015-09-16" version="1">MAKCYDWYGNDDIGRTPCSQDGSVPQCCSDGEVCSSNGLCMVTVPDVGTKYWMNTCSDYNWINASVPACPSQCADIRPGGGNGVTSCGRSTFCCTSRSGGSCDCNNATETFSLGESHSVTKITTATLSPSSTVSLSSTSTTAESDSSATSAPPDPTGDTKSDNNLGVGLGVGLGVGIPLLIGAFAAFWFIRRRRRRAVAGSVPMEAAAPSFQDKMTPSELGSTLPMSMQKGPPQELPTKQARAPLELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2S7</accession>
    <name>A0A0G4P2S7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S004g000489</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P2S7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL20548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="408" mass="45422" checksum="93C5DF4B1F5B21A2" modified="2015-09-16" version="1">MKVKKPRGIRHDRDCGRCKVRGVKCDLNRPRCQACLQSGEACNYPHRVVWVDDKKSKSPKSTSKIPNEETHIEVPTKSASTINLYGFVDLLDTFCQQLQSSSRDIPEEGIQLISRTLSFARSRIQDANNKESLQSHLVALTNLSQVIQSAHPIALFGIATFAMFEVCCGSFGNWHCHLQGARSLLDLHCQHKADLDNLCDEIAGLADVLAYLVWFDVTGALVRESPLIFEDWHRETLSAGFFDSVGCPPDTFDLFVYLAKYPDRDGIRTMDLSSRAMAQILQLNAGDSTDRNLAATVYRGAAAIMAFSRAGMTTGGDPPASAYHSNVVSSMVDRACQAIADIPSTSRFYVHLATPTYLTGMSASTTRQCDIIRNYWRNCQSCEFPRYPDAEAQCERRWRIFGVGVIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P319</accession>
    <name>A0A0G4P319_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Altered inheritance of mitochondria protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">AIM11</name>
        <name evidence="6" type="ORF">PCAMFM013_S004g000666</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AIM11 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P319"/>
    <dbReference type="STRING" id="1429867.A0A0G4P319"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038814">
        <property type="entry name" value="AIM11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39136">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39136:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL20725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="201" mass="22119" checksum="F19179EF7C28CF61" modified="2015-09-16" version="1">MVSLFGWGSSPTPTPETSQPKPPQEKPTPDESATPPPTQTQLAQPPSPQTNTNLKLLFGGMTFFALSVLVTRRAFHKKRISCIPPFYTSSTYHQPHSNSAGDAFEALNLATLNVISFGLMAGGAVGYALNINGLEDMRRFVRNGLQGGSDTPVKSDEELETEVTEWVTKILGDKFEKQLEKEKMKKAFREEKESQGTKESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3S0</accession>
    <name>A0A0G4P3S0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sugar/inositol transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S005g000150</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL20986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P3S0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF3">
        <property type="entry name" value="HEXOSE TRANSPORTER PROTEIN (AFU_ORTHOLOGUE AFUA_8G04480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="41"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL20986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="525" mass="57659" checksum="D7DC53B702F4F903" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6R7</accession>
    <name>A0A0G4P6R7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S007g000003</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CDC50/LEM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P6R7"/>
    <dbReference type="STRING" id="1429867.A0A0G4P6R7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005045">
        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926:SF0">
        <property type="entry name" value="CDC50, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015840">
        <property type="entry name" value="DUF284_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL22022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="401" mass="44797" checksum="A47CDDD235ED1F32" modified="2015-09-16" version="1">MSQEVTRAESIEEQERAREDGDKKPKSRRPANTAFRQQRLKAWQPILTPKSVLPLFFIVGVIFAPIGGVLLWASSLVQEISIDYSDCSRQAPTDSYASVPHYSATFKSSKAISAPTWSKSVNESDSGAVTCTLLFEVPNELPAPVFMYYRLTNFYQNHRRYVQSLDLNQLKGDAVSYNTIKGGTCDPLAVNTTAQKVYYPCGLIANSFFNDTIGRPQILDPNASENEKQYYEMTTKGIAWDSDKELIKNTKYNMDDVLPPPNWVWASKDGVYKEDPKLHENEAFMVWMRTAGLPSFSKLSRRNDTHGMPAAKYSIEIVDNFNVTEYDGTKSILISTRTVLGGKNPFMGIAYVVVGGICVVLGTLFTVAHLVRPRKLGDHTYLTWDSNQPSTAIATGRDNAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P719</accession>
    <name>A0A0G4P719_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alkyl transferase</fullName>
            <ecNumber evidence="3">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S007g000092</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="3"/>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P719"/>
    <dbReference type="STRING" id="1429867.A0A0G4P719"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016094">
        <property type="term" value="P:polyprenol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291:SF43">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT DHDDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL22111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="259" mass="29414" checksum="C23CF82A3032D1E9" modified="2015-09-16" version="1">MHIFQVVYKYLEYVFIYINQFVLETLAQGPIPQHVAFIMDGNRRYAKDNSISMAAGYLAGAKALVKVLDTCFDCGVNVISLYAFSLENFNRPKEQIDVLMKLLEGTLGELGENDPLVKKHNLQIRVLGRLELLEDHVLRAISKTMHATKNNRGKIVNVCVAYTGRDEIASAIRETVAGSGFPSKITAKSLTENMFMGFPPLDILIRTSGVYRLSDFMLWQCHQDTDIEVVAMNWPDFGRWDIGLIFLKWQSRKRALAYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P724</accession>
    <name>A0A0G4P724_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S007g000119</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P724"/>
    <dbReference type="STRING" id="1429867.A0A0G4P724"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053274">
        <property type="entry name" value="Fluconazole_resistance"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025124">
        <property type="entry name" value="Gag1-like_clamp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28065:SF1">
        <property type="entry name" value="DUF4050 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28065">
        <property type="entry name" value="FREQUENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13259">
        <property type="entry name" value="clamp_Gag1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gag1-like clamp" evidence="2">
        <location>
            <begin position="89"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL22138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="405" mass="44410" checksum="5266526124880F35" modified="2015-09-16" version="1">MMATGSRDTSVREAKLFVKEVVRNDWDFDAGVPSPCSADGTLCHNREVCEWRVREFDTPTSELEPQSSDSEQEYDPSAVLKLAPGDAGIERRRKRRRQMDDEMAWNEGLRLWMARRDAWCGAKTRRQIRTEEEKRKVTGAQTDTTDQSNGVELGENDATSSGSSQSAMPAARGSEGIGASDLAVRTETSLSIADREKSEELQQRVDMTSGQQEDQEEGLSTAPDEGAKRKASSETNITEPDQKVAANVPTQLTSFPAVEDQTEEEKVEEELDEPLCPVAPPFISDENPVRATINPAIYPSIYTKVVVQGMTPTIPVNLAHLTKAMVQGWKSDGQWPPKPAVTSIVLADDASVPKKNTDRSAEEAPQGRRKNSITNAVKKVFHFGSHPFHRRGSQDTGNGAGGPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P750</accession>
    <name>A0A0G4P750_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCAMFM013_S007g000149</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P750"/>
    <dbReference type="STRING" id="1429867.A0A0G4P750"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097435">
        <property type="term" value="P:supramolecular fiber organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000003">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000009">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="14">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="15">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CRL22168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="447" mass="49907" checksum="CC731DC7534F91E9" modified="2015-09-16" version="1">MREIVHLQTGQCGNQIGAAFWQTISGEHGLDGDGQYNGTSDLQLERMNVYFNHASGDKYVPRAVLVDLEPGTMDAVRSGPFGKLFRPDNFVFGQSGAGNNWAKGHYTEGAELVDQVLDVVRREAEGCDCLQGFQITHSLGGGTGAGMGTLLISKIREEFPDRMMATFSVVPSPKVSDTVVEPYNATLSVHQLVEHSDETFCIDNEALYDICMRTLKLSQPSYGDLNHLVSAVMSGVTTSLRFPGQLNSDLRKLAVNMVPFPRLHFFMVGFAPLTSRGGQSYRQVSVPELTQQMFDPKNMMAASDFRNGRYLTCSALFRGKISMKEVEDQMRNIQSKNQSYFVEWIPNNVQTALCSVPPRGLKMSSTFVGNSTSIQELFKRVGDQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQEASVSEGEEEYLADDIVDEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7W9</accession>
    <name>A0A0G4P7W9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S007g000381</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P7W9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF130">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL22400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="325" mass="35576" checksum="ACB00BEFB4D06238" modified="2015-09-16" version="1">MPAYASGAIETGKEKENSTQTTDVPTRDRSNAPLLPPPDGGFHAWAQVVSGHLVVALTWGYASSFGVFQNYYESTLPQAPSDISWIGGFQVFCLLFISTLSGRATDAGLVRPVVALGGLLLVIGTFMTSLAVEYWQIFLAQGLCIGIGQGLMWLPTVTLISTYFVRYRVFALTAAATGTSTGGMVFPAMIQYLTPKIGFPWAVRCMGFVVLFMVIITLALLRPRLPPRKAGPLVEWNAFKEPAYMLFTLGVFLLYWTLYFDFFYVQVYATEKLGLSQEAGVNLITVTNALGIPIRAPCGYLADRYIGPLNLLIPWVALCGILMFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P8N6</accession>
    <name>A0A0G4P8N6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S008g000096</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P8N6"/>
    <dbReference type="STRING" id="1429867.A0A0G4P8N6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL22667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="548" mass="61886" checksum="6B216A30F6C34AD9" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P8R8</accession>
    <name>A0A0G4P8R8_PENC3</name>
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        <submittedName>
            <fullName evidence="4">Zinc finger, C2H2-like</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">PCAMFM013_S008g000129</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CRL22700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
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    </dbReference>
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    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="188"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <end position="117"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="2">
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            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL22700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="229" mass="25286" checksum="C75CD1C07DFFDB56" modified="2015-09-16" version="1">MVCAFSDEHSDAFPFEGETLPHTSAFVQNTPRSTLPYLEQNPPFSSSIYDPYIQSSWALHGFGLSIPAKSPQLGMDSTTGWVRDNASPAGAENTINGSCIQFERSGSNDHQQGQFSTPVGVPLKDATCEVSPSDDHTSRRRRSKPNIKRSLTSPIRCDWKDCTNPCLFTRDTSLWRHIKEKHILPGAFKCSSPSCDMSFGRRDKLNEHLRSSHADGKGQKGGCCHSCHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P944</accession>
    <name>A0A0G4P944_PENC3</name>
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        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P944"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Srf1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
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            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL22822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="372" mass="41255" checksum="11E11880339DC940" modified="2015-09-16" version="1">MMDSPKDSAPGRVFGERLAEKFPPIPESSPLPGPLTVDTESAVRNKTSDSALARTNGQTAEETAYSQRSVLRSLPAWIRSVDEPAEDGDEATATDRLLPSQPNDAFVAQHNHSPYSSSKPQPNHATTNGLFEDESPPVNRESRWVTFSRAIQYPREPDREEQHVTSEWLNENHGDYLQPWRGKDLEGDSPEYPLHSGGRRDIWITRFRKTLLRSPIVPLILRMTVWCFSLSALALGGSIQHMSNQGNHPQGPSALMAIIVDAVALVYLLYITFDEYTSKPLGLRSPSAKARLLLLDIFFIVFDSANLSLAFASLSEVTGSCTEAEVNQTIDPRNDGICTRQKALASVLLVALLAWLMTFSISVLRLVERVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P9F8</accession>
    <name>A0A0G4P9F8_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">General negative regulator of transcription subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S008g000387</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793141">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20710">
        <property type="entry name" value="NOT1_connector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000012">
        <property type="entry name" value="Ccr4-Not transcription complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.840:FF:000002">
        <property type="entry name" value="Ccr4-Not transcription complex subunit (NOT1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.790:FF:000003">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.800:FF:000003">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1,putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.840">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1 TTP binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007196">
        <property type="entry name" value="CCR4-Not_Not1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055454">
        <property type="entry name" value="CNOT1-like_NOT1_connector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032191">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024557">
        <property type="entry name" value="CNOT1_dom_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032194">
        <property type="entry name" value="CNOT1_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032193">
        <property type="entry name" value="CNOT1_TTP_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038535">
        <property type="entry name" value="CNOT1_TTP_bind_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040398">
        <property type="entry name" value="Not1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162:SF8">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25097">
        <property type="entry name" value="ARM_Cnot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16415">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16418">
        <property type="entry name" value="CNOT1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16417">
        <property type="entry name" value="CNOT1_TTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12842">
        <property type="entry name" value="DUF3819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04054">
        <property type="entry name" value="Not1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 HEAT repeat" evidence="13">
        <location>
            <begin position="640"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 TTP binding" evidence="12">
        <location>
            <begin position="819"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 CAF1-binding" evidence="11">
        <location>
            <begin position="1034"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1" evidence="10">
        <location>
            <begin position="1319"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1-like NOT1 connector" evidence="14">
        <location>
            <begin position="1643"/>
            <end position="1749"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-Not complex component Not1 C-terminal" evidence="9">
        <location>
            <begin position="1925"/>
            <end position="2293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="80"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1533"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CRL22958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="2306" mass="257078" checksum="9D47B91A6F3302B2" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P9U6</accession>
    <name>A0A0G4P9U6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S009g000015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P9U6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL23075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="87" mass="9590" checksum="1F2120B31E81FB93" modified="2015-09-16" version="1">MCKSLGEAGADIVSIQLPNDPNAASLSKHLAEIGRNFWATSPLFRGHLMQFPTEADTAVPPDEAATERYGLQQLYPKWDIRRPLGNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAH8</accession>
    <name>A0A0G4PAH8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxylesterase, type B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S009g000245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PAH8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PAH8"/>
    <dbReference type="ESTHER" id="penca-a0a0g4pah8">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="1">
        <location>
            <begin position="27"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL23305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="527" mass="56557" checksum="EFAC66070D1B2004" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAJ4</accession>
    <name>A0A0G4PAJ4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="3 6">2.1.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S009g000266</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = 2-dehydropantoate + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the PanB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="3 6"/>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PAJ4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PAJ4"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000003">
        <property type="entry name" value="3-methyl-2-oxobutanoate hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001452">
        <property type="entry name" value="PRK00311.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881:SF0">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL23326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="338" mass="36541" checksum="C734FD517EB4D440" modified="2015-09-16" version="1">MTLNAINCLRRPALHFRSLVIPLRQSPIKSCIAQYSSHSPMGSTTASTRKKVTIQTIQNLYKKNEPITVLTASDFPSGHVADTAGMEIVLVGDSLAMVAMGMEDTNEVTMDEMLLHCRSVNRAVKSAFTIADLPMGSYETTPEKALTSAIRMVKEGGMKGVKLEGGAEMASTIRKISQAGIPVMAHIGLTPQRQHSLGGFRVQGKSAAGAVKLLRDALAVQKAGACMVLIEAVPPEIAEIVTRRLSVPTIGIGSGNGCSGQVLVQVDMLGNFPEGRFLPKFVKTYADVWGEARRGIEAYREEVKSRAFPSVGYTYPVSKEVLEEFEKVVDEVADEKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAL4</accession>
    <name>A0A0G4PAL4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chaperone DnaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S009g000275</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PAL4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PAL4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000048">
        <property type="entry name" value="DnaJ family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000024">
        <property type="entry name" value="Mitochondrial protein import protein MAS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="135"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="135"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="368"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL23335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="415" mass="45566" checksum="35125832901FC891" modified="2015-09-16" version="1">MVKETKFYDTLGVAPTATEAQLKTAYKKGALKYHPDKNTNNPDAAEKFKELSHAYETLSDPEKRQLYDQLGEEGLEHGGGGGGMNAEDLFSQFFGGGGGGPFGGMFGGGMRDQGPKKARTIHHVHKVNLEDIYKGKVSKLALQKSVICGGCDGRGGKEGAVKECAGCNGSGMKTMMRQMGPMIQRFQTVCPDCNGEGEIVRDKDRCKKCNGKKTVVERKVLHVHVDKGVRDGHKIEFRGEGDQMPGVMPGDVVFEIEQKPHARFQRKGDDLFYQAEIDLLTALAGGAIHIEHLDDRWMTVNIAPGEVIVPDAIKVIHGQGMPSFRHHDHGNLYIKFDVKFPKKEELQNLELLEQVLPPRSEKVVPPTDAMVEDFELEDPENEHDQARAHGAAAHGMDEDDDDVPGGAERVQCASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAS9</accession>
    <name>A0A0G4PAS9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Glucose-methanol-choline oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S009g000361</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PAS9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PAS9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9 10" id="KW-0274">FAD</keyword>
    <keyword evidence="7 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="11">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL23421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="563" mass="62727" checksum="4E5BA4EC64748D7C" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBA5</accession>
    <name>A0A0G4PBA5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S010g000034</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL23596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="67" mass="7619" checksum="24DA030D51E6FF67" modified="2015-09-16" version="1">MYKVTSGRNGRRSSYDNSGTRLFLTPQMWKVGMRDLAVTSLTPDTFKVRKKPGIPETQSAARVSYDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBR9</accession>
    <name>A0A0G4PBR9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793143">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195209" evidence="1">
        <location>
            <begin position="22"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL23714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="182" mass="19686" checksum="86681BA9D52F3262" modified="2015-09-16" version="1">MHVSNLFYYFLVQACWSYALASPSHHVKRGAETNATLYAYGVNASSWPIAYGLDDGLLYITENPDDSAANVTPLSWDLASITGECWIANATFVNGTAAGSLFIEQNNTIGVLPYTRVAYINGTVSGFALFASQLVYNNNTQLEAQFWAKSTKTSGVYGLIWTPDGDTPTGDFPVVVKASEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCW5</accession>
    <name>A0A0G4PCW5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S011g000083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PCW5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL24089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="118" mass="12602" checksum="00173BD3213BC5A0" modified="2015-09-16" version="1">MTSSVDSIRPDDSARTGARTPTGTAQASSAGVDVSELSPPGSQTKQEAGASVGDIGTALEQHSGQTAEKAIDASVAAWKSKRAQEDYHRAMEYLVDRDFKLDEFGDPFDERDLAEKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDI3</accession>
    <name>A0A0G4PDI3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ribosomal protein S5 domain 2-type fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S011g000377</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PDI3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF2">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT MTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="10">
        <location>
            <begin position="41"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL24383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="315" mass="33480" checksum="BBC4EE874ABD3DD6" modified="2015-09-16" version="1">MADRRRINGPPGGTRPPVFASLQESSTGIANRAQRQRQPAELRKIFLKTGLIPTASGSSYLEFEPSASLAAARSNPKSLIPPSSALKLACTVHGPKPLPRSAAFSPNLVLTTHVKYAPFAARKRKGHIRDASERDLGVHLETALRGAIIAERWPKSGLDITLTIIEAEDDRWWGDAPDSHDASWGMMNVLAGCITAASAAIADAHIDCLDLVSGGVAALVSDDSNQSASSAPRLMLDIDPAEHRSILSACVVAYMPARDEITELWLKGDSSRAALEKDDGRTGHEALIDGAVDAARGANIVLAEAVRESIARSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDM3</accession>
    <name>A0A0G4PDM3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S012g000001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PDM3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PDM3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF230">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL24392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="448" mass="50631" checksum="2BF936FAB34DA92C" modified="2015-09-16" version="1">MREYTTTIRAIDRRDGTRPSNLGESVGEPPSEFIPIFKFTTIIYLVGMPVSLTVQAALAFCFVYYLYSIIHAVYFHPLRRVPGPKWWIAFPVLRHLSAIRGLVDLDIPRFHLKYGPIVRFGRDEVSFIDPEAWKDIYGHNNKHGQLPKVKNSASNPLDIVSSNDVDHSRYRKSLSHAFSAKGLQTQEPYINNYVDQLLARLKDVAQSRTSTDMSKWYELTTFDIVGDLAFGEPFGGLVSSEYHDTVKTIFESIKLFPFVKMRDDYPILFSFISLMIPQRLLEAQRQQNAHTRAAVMKRLANTSAYNRGDFMDSMTRNRGDKDGLTDDELVANANILIVAGSETTATLLAGVTYFLLRNPETLRKVVTEVRSVVQTESDITPTSASANHPYPYMWACIQEAFRLYPPVPTGLQRVTLESMLIAGHEIPPGVGSLPLQTTGIRFTLITRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDQ1</accession>
    <name>A0A0G4PDQ1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sterol-4-alpha-carboxylate 3-dehydrogenase ERG26, decarboxylating</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15 16">C-3 Sterol dehydrogenase ERG26</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13 14">C-4 decarboxylase ERG26</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Sterol-4-alpha-carboxylate 3-dehydrogenase erg26, decarboxylating</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PCAMFM013_S012g000025</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FM 013</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">Heterotetramer of ERG25, ERG26, ERG27 and ERG28. ERG28 acts as a scaffold to tether ERG27 and other 4,4-demethylation-related enzymes, forming a demethylation enzyme complex, in the endoplasmic reticulum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PDQ1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PDQ1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000252">
        <property type="term" value="F:3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000346">
        <property type="entry name" value="C-3 sterol dehydrogenase/C-4 decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43000">
        <property type="entry name" value="DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="17">
        <location>
            <begin position="80"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00081267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00082106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CRL24416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="412" mass="45560" checksum="78B414526E4E9590" modified="2015-09-16" version="1">MSAKKRTLELGNVLVVGGCGFLGWHIVDHLLNFPSETDPSYALPKPVGDARFEYPTLGSRYPDYHSTVSVVDLRTTNNRLPGAKYYDGDITSVESMLEVFRAVKPDLVIHTASPSMIEGNKPLLHKVNVEGTRTLLEVAGGEHGDWGGKCKAFVYTSSSSVVHDTQSDLKNVNEEWPYIRGPAQKEYYSETKADAEELVLKYNKTSPNQMLTAAIRPAGIHGEKDTTVTHKILEHGSQASDRVLRMQLGDNDNLFDFTYVGNVAYGHLLAAHRLLASYDLHAAGKGGPLDYERVDGEAFNITNDSPVYFWDVTRAMWALINRVVEPEQVWALPEGLLETVGGLAETVMGLFGKTPRLTARTVRYSCMTRYYSTEKAKYRLAYLPVVPLDEGIARAVGYIVAQQQADAGKKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PE27</accession>
    <name>A0A0G4PE27_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S012g000210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PE27"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL24600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="63" mass="6817" checksum="B4E687CD293CDEDF" modified="2015-09-16" version="1">MEHDTNKTKKGCHGSPSAAGGSRYMQLSNAQEDARMAEEFGEPLSSPSKAQVTREDPHLQVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PEN5</accession>
    <name>A0A0G4PEN5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S012g000326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PEN5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195410" evidence="1">
        <location>
            <begin position="18"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL24716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="62" mass="6259" checksum="3DC7A2516BD4AC82" modified="2015-09-16" version="1">MRASVIILGFLATLTVALPEAYPKAEIACQSNTMPCTAANCAVEGCCCEGLTCGSNGTCTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PFH5</accession>
    <name>A0A0G4PFH5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 14">Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase</fullName>
            <ecNumber evidence="3 14">2.7.4.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PCAMFM013_S013g000332</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:37459"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:37460"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:10276"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:10277"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
            <location evidence="1 14">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the histidine acid phosphatase family. VIP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.24" evidence="3 14"/>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL25089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4PFH5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033857">
        <property type="term" value="F:5-diphosphoinositol pentakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052723">
        <property type="term" value="F:inositol hexakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052843">
        <property type="term" value="F:inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000036">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11950:FF:000002">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000059">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037446">
        <property type="entry name" value="His_Pase_VIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040557">
        <property type="entry name" value="VIP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750">
        <property type="entry name" value="DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750:SF9">
        <property type="entry name" value="INOSITOL HEXAKISPHOSPHATE AND DIPHOSPHOINOSITOL-PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18086">
        <property type="entry name" value="PPIP5K2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="VIP1 N-terminal" evidence="17">
        <location>
            <begin position="120"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp fold RimK-type" evidence="16">
        <location>
            <begin position="346"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="469"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="550"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="668"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="996"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1267"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="50"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="471"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="504"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="996"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1024"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1278"/>
            <end position="1287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF18086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CRL25089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1287" mass="143465" checksum="D772E2CEA2B3B561" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGG7</accession>
    <name>A0A0G4PGG7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S014g000283</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PGG7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056146">
        <property type="entry name" value="DUF7729"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39460:SF1">
        <property type="entry name" value="C6 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39460">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24855">
        <property type="entry name" value="DUF7729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195521" evidence="2">
        <location>
            <begin position="25"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7729" evidence="3">
        <location>
            <begin position="80"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL25387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="324" mass="34900" checksum="714CBD9524FD4B65" modified="2015-09-16" version="1">MSRLYHIYNLLILITILCLSTTRAESVEPTDLPVPRSAWHPSGEIKTTDRQSLQAPTEEITTTIRRRTIVTASTSTSTGMPKPFDTLSYNFANSSTCIDFFTKWRANTTISNCNAISLLIENSNAFFHTLNSAPATSRILDTSCSSDVSQCASIMTALAADLLKPDNCGDDYENGNSVVKGTYRDLVAYEPMYRATCLTNPSTKDYCFVDAVSNSTAPDDYSVYLMPLGTPLTSGDVPTCNKCLKATMDLFSGWARRDGQSLDSTYLPSAKIVNAHCGDGFASTNITVGSADVRAGAGLAVPLPKLGIVTVMALVLGIMLTGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGK4</accession>
    <name>A0A0G4PGK4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S015g000070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CRL25484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PGK4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF128">
        <property type="entry name" value="ACYLTRANSFERASE 3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="416"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="40"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL25484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="474" mass="54210" checksum="CDF17C55168B5463" modified="2015-09-16" version="1">MQYLQPSHLYTRLIDTIPTSIPLPWSSDPAVKGDPKKSVKWIDGLRGIASFLVVLTHLARAWDYGLFSPRDNEKATPRILQWPILRIPWQGRLGVTIFAFLTGYVCALKPLKLSRAGDTTAAFETIAKSAFRRPPRLIFPATIALFISWIVAQFGGFIVANRSDCWWCRYAAPDLADSFWKELLRLPMNFLSTWTTGYMAYDDHQWALLPLLCSSMLVFLVLSATMFVQFRYRVVVYIEMLLYFHQNAGKDIETFQMQAIYGMLLSDFSYHTALKDWIEKHPRGRKMITIPLTIFALLLASYPGEHPEWAGWSNVMLKASHYIFPPGVNVGKRYTALAIDMIILAIFFSPSTKDFLSSRPLLWLGKQSFAVYLIHGTMLRVVLCWMLYGISGQPWKGPEPLTDDKRDDWLRIRPPWVVGISIPIWIGLVYILAALWTAYVDTFCASMTQKLEKAVFVEDEKTPLPSQSIPMQTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGL8</accession>
    <name>A0A0G4PGL8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">PCAMFM013_S014g000271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PGL8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL25375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="494" mass="55340" checksum="A5ACC9355655086C" modified="2015-09-16" version="1">MTSPSHSNSHRPLPSADRADMAFAKSLKLDPLGIVDTRLTMTDSPTDRFFSPLFAPLTGFDGTDERQPVNQTKTEASPKQAHRILELRESFRGFGSNRKCPRLELDVAVDKYHTLDGLAEPLNPQNTPASNSERENEEESTESLRCYEMENVRMSPTPQTEEFNFDCFQVSPEASLVREDDGSESPKPSKLRRLSVGRRQWIKPPVGVLLSHQPSVNAGTFNKLGDPDSLLRCARFSPPASLSPPSRVIHRPQPSIERRQDYVALHRQKKQYQKWKVTGRANSRKSSPNKMPTNRTQATRIPKNHDLRGSSLSSLPYRETRHTSFLARVGLGSDAREVRAGNVGDTPVVDNSNIASNTEQNLPAFLAVSFSLYKPQPASTEKGSKYTFRFRVTRTDLPQQPSPHFPLEFEHVTCHPTIDDLVFHTCFIIPLVVLLPLSVIFAATHPLVNTRAGAVMLYLARALLYLLMNIINLVLSKCGVSLGYQWNPDPVHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGV3</accession>
    <name>A0A0G4PGV3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S015g000088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793148">
        <property type="protein sequence ID" value="CRL25502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PGV3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PGV3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195326" evidence="1">
        <location>
            <begin position="20"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL25502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="244" mass="25937" checksum="42D97F74D0070842" modified="2015-09-16" version="1">MKFSQSLLFALPFLQSAAAQGGGMVGLGWSVENVTDAGLSEIFFPMDISGAPHEGGFYFAQQFGFVNQDNVGYTGLQPSVNDHGLPVIHGVFSSFNEGTTSDDPNCSDGADGGPGVSCAVNIVSSYDHQYQLHIKNTEGTKWVGTLVDVVKGNSTQIGSYTLPAGSKGIQSSQMGFVELYKWNDGKEEHVCSDVPKQSVIFGAPISKGYTGSLSEPYEYGDCVGESQFETHSHSDGSYSVTVGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PHT0</accession>
    <name>A0A0G4PHT0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S016g000110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793149">
        <property type="protein sequence ID" value="CRL25829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PHT0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PHT0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL25829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="191" mass="21541" checksum="F5147976A90AF86F" modified="2015-09-16" version="1">MATSTPSLKNNLAFLHTMLLMKPNSPGEAVQAVWQTIVSQWFPPSDGYKWGIKVPILANNTTPDGTIIQVYQVVQIPAVTFEWVEHPIFIVLCKRPSSDSETLVGWDDTMQNHFLHHLSQNSNSLGTERLYGALAIGKKVKFYRFDGRAQPDQRLAQLHQDTIDLEKANGSAQVEGMMNYIKTNAWQWVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PI34</accession>
    <name>A0A0G4PI34_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Uridylate kinase</fullName>
            <shortName evidence="9">UK</shortName>
            <ecNumber evidence="9">2.7.4.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:UMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Deoxycytidylate kinase</fullName>
            <shortName evidence="9">CK</shortName>
            <shortName evidence="9">dCMP kinase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Uridine monophosphate kinase</fullName>
            <shortName evidence="9">UMP kinase</shortName>
            <shortName evidence="9">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S017g000030</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>UMP + ATP = UDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <text evidence="9">Predominantly cytoplasmic.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.14" evidence="9"/>
    <dbReference type="EMBL" id="HG793150">
        <property type="protein sequence ID" value="CRL26047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A0G4PI34"/>
    <dbReference type="STRING" id="1429867.A0A0G4PI34"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000315">
        <property type="entry name" value="Adenylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03172">
        <property type="entry name" value="Adenylate_kinase_UMP_CMP_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006266">
        <property type="entry name" value="UMP_CMP_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01359">
        <property type="entry name" value="UMP_CMP_kin_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMPbind" evidence="9">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="9">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="21"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="69"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="105"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL26047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="209" mass="23009" checksum="4CEA93E700AD1E40" modified="2015-09-16" version="1">MSTPRFSTNDVTVVFFLGGPGSGKGTQSANLVKDYGFVHLSAGDLLRAEQVREGSQYGELIREYIREGKIVPMEVTVALLSNAMAESLATSPPPAGTKARFLIDGFPRKLDQAVFFEETVCPSELVLFLDCPEDVMEARLLKRGETSGRDDDNAASIRKRFHTFVETSMPVVDDFKKKDKVVWVKADSSVEQVYAEVKAGIEARGLQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PI74</accession>
    <name>A0A0G4PI74_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dual specificity phosphatase, catalytic domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S016g000172</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793149">
        <property type="protein sequence ID" value="CRL25891.1"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PI74"/>
    <dbReference type="STRING" id="1429867.A0A0G4PI74"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033260">
        <property type="term" value="P:nuclear DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="DSP_fungal_PPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PPS1p Protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053239">
        <property type="entry name" value="Dual_spec_PTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047949">
        <property type="entry name" value="PPS1_DSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
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    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47550">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE PPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47550:SF1">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE PPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="386"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="497"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="565"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL25891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="675" mass="76034" checksum="9E14EF8378DD7B04" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PIK2</accession>
    <name>A0A0G4PIK2_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S016g000282</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="HG793149">
        <property type="protein sequence ID" value="CRL26001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PIK2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PIK2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF10">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type III-like" evidence="8">
        <location>
            <begin position="321"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL26001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="415" mass="46775" checksum="E7D979947449EA16" modified="2015-09-16" version="1">MIKEAWPEFLDRKYCTRMSFALSPHSDGLHTFSVITTGVAKVFVNGEEVFHRPQEPILQPESFYFYKAKIERKFSLSLAKDQRVKIDVHSWAADADVLGCVEGTVFQGSSLRFMEYFDIPKAIHDASIIASEADVAIVFVGNTNEIESEGYDRETMDLTKDQYLLISAVAAQNPKSIVVNFSGSPVTVNPFIDHVPVFLQSWFAGQECGNSVAKVLTGVVNPCGKLPMSWPRKNEDNPAFNNFPCDDNDVLRYEENLRVGYRFYDAQDTPSPQFPFGYGLSYTTFELFSFKITSAEFGEPNQTKVTLACEAGNTGSRAGKTVIQIYVSYNGATTGAHHPRPPKELKSFRKIHLELGERRWTDFVLDKYAFSFFDPQEGQWKLQEGPYTVHASFSSAEKPLPVELNVPKSHYWKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PIQ1</accession>
    <name>A0A0G4PIQ1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Carboxylesterase, type B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S017g000046</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793150">
        <property type="protein sequence ID" value="CRL26063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PIQ1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PIQ1"/>
    <dbReference type="ESTHER" id="penca-a0a0g4piq1">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195380" evidence="3">
        <location>
            <begin position="22"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="36"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL26063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="547" mass="59725" checksum="C61AE085AA923A71" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJG6</accession>
    <name>A0A0G4PJG6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S018g000253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJG6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL26560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="245" mass="28101" checksum="4E621BA9A9302DF0" modified="2015-09-16" version="1">MPPRNQSSKVWGQWSRLVVNRDTPKKLKYTTSDLAPLNIKLVSANDTDDASWFEPWDKLDNLTLTEPESLNKLPTLDLEADEVLDVGTRQQRHSSFCYELWIDEKCEFYTVDNIRAPGYPFTWGWYPLSLEGFCVRDRDSQEALHPHLQMAMFSFDCPDEGSILASELSALVQIIGIRSRQPSFLGTPNIAALNWKDEGKGKKHGELKLTVTLEKAMDLAGENRNENEERMEEIIRWMACYPISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKI0</accession>
    <name>A0A0G4PKI0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NADP oxidoreductase, coenzyme F420-dependent</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S020g000069</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793153">
        <property type="protein sequence ID" value="CRL26910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKI0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PKI0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF21">
        <property type="entry name" value="HYPOTHETICAL PYRROLINE-5-CARBOXYLATE REDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="3">
        <location>
            <begin position="7"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="4">
        <location>
            <begin position="189"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL26910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="292" mass="30736" checksum="4D96AF07ADBE0BBD" modified="2015-09-16" version="1">MASGQTLGFIGCGNMGGAVLNGLLNSAFSSPSTETTPNPITRFIACTKTAASAARLQTKIAPEHEQLIKIVSNQTVQTMQESDIIILGCKPFMAEAVLSEPGVREALSNKLVISMLAGLTCSTLTLLINPDPSSTDQPHVMKAIPNMGAQFGQSMTIIETPASTIPESMVAVTEWIFKHVGAVKYLGSEQIGLATVLVGATMATLTLPIEGLLDGCVAEGFKRVDAMELVLQGIRGLSAVLESGQHPGVVRESISSPRGCTIQTLLSLEEAGTRSDFAKAIVRGNTHLKEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKK4</accession>
    <name>A0A0G4PKK4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S019g000148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKK4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL26731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="227" mass="26184" checksum="6B3E796CAE56B7CD" modified="2015-09-16" version="1">MGLFSGKSRSKAQRQPSEPPYETPEYGQQPVMRRTAQPEHSKFGPHFQKGPLQEQIYERRADGERIPTGHPDLRDRAHSFHQPREHHEYSDPFKKIPKQWSRQMQAEREHYHALCDRKEEDQAIRLADALPVGRKVKPHPNDSTVIKAGITANEAWAAHCNMGAQARGGFAQKYPQSYENLDAIATHEKEVAKSRARAEGYRDKSNFLAEKHTRWALQMDKAQKRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKP7</accession>
    <name>A0A0G4PKP7_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S019g000188</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the oxidative stress response and detoxification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKP7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PKP7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd10293">
        <property type="entry name" value="GST_C_Ure2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.130:FF:000016">
        <property type="entry name" value="Glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF3">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR URE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="6">
        <location>
            <begin position="7"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="7">
        <location>
            <begin position="95"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL26771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="225" mass="25565" checksum="C7B3B465B4575A1B" modified="2015-09-16" version="1">MSLETITLWTLKGHAGTPNPWKVLMILEELKLPYQPKLVDSADLKKEPYESINPNGRVPALEDPNTGITIWESGAILEYLVDTYDKEHTISFPTGSKEYYESKQWLHYQMSGQGPYFGQAAWFTIYHPEKVPSAVERYVNEIRRVSGVLNRSLQNKEYLVGGKYSYVDAAFVPWFEVAGLLWSNEIGLEKNFPHVNSWLNRIKARPAVAKTIDDKVKAAAAAEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKW8</accession>
    <name>A0A0G4PKW8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S020g000158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793153">
        <property type="protein sequence ID" value="CRL26999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKW8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL26999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="54" mass="5855" checksum="063F49121A8E0940" modified="2015-09-16" version="1">MTTRSFGQATLGTAYETLPLAYILKSSKFFPSGSVTRLQPEVQGTISFPLRDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PLB2</accession>
    <name>A0A0G4PLB2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Isocitrate/isopropylmalate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S020g000097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793153">
        <property type="protein sequence ID" value="CRL26938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PLB2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PLB2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050501">
        <property type="entry name" value="ICDH/IPMDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011829">
        <property type="entry name" value="TTC_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02089">
        <property type="entry name" value="TTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43275">
        <property type="entry name" value="D-MALATE DEHYDROGENASE [DECARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43275:SF2">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="2">
        <location>
            <begin position="8"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL26938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="358" mass="38812" checksum="65C08335BAFCDA76" modified="2015-09-16" version="1">MASKNSYRIASIPGDGIGVEVVSATIQVVEKLAKTLGTFNINFEHIPWGTAYYKQTGRYVSEDYLDTLRQYNAILFGAVGAPDVPDHISLWGLLLALRGPLQLYANVRPVRTFPGTKCPLNTATNGIDWMLVRENSEGEYAGQGGRSHVGQQWEAATEVALFTRVGIERIMRFAFETARSRPRKFLTVVTKSNSMRNGMVLWDEIAALVAKDFPDVSWDKMLVDAMTVRMVMKPESIDTIVGTNLHMDILSDLAAALAGSIGVAPSSNLDPTRKSPSIFEPVHGSAFDITGKGVANPVATFWSAAEMLIWIGEKDAAAQLMGCVERVCAKGILTPDLGGSSDTQGVVDAVCLEIEKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PLC4</accession>
    <name>A0A0G4PLC4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S021g000084</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793154">
        <property type="protein sequence ID" value="CRL27169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PLC4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PLC4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF2">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL27169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="251" mass="26614" checksum="DE07C832CEF822E6" modified="2015-09-16" version="1">MPYSLSGRNVLITGGSRGLGALSAEKFASEGSNVAINYMSNKEVADKLASDIASKYGVKTVVIQGDAGVKDDCINAVKTTIEKLGGLDIIISNAGWTKMTNFGDLDAMDDDDWDKCWSVNVKSSFYLFKAALPTFNANPEGGVFLITASIAGVTPSGSSLPYAVSKAASIHLMKCLAKSQGAKIRVNAILPGLLLTEWGQRFPSDKIESWTNATTLKRAPEVEDCADMFITLAKNASITGQTVQIDSGFAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PLS1</accession>
    <name>A0A0G4PLS1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S022g000022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793155">
        <property type="protein sequence ID" value="CRL27342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PLS1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL27342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="195" mass="21933" checksum="DCF61D9C8205764A" modified="2015-09-16" version="1">MWWKIGIEDPKDQTQRPTDFVGSDELMMSYGDHPRSQAQGIIVLFVMQTPIQETNVTITETPCAQTIMNLHSECTIVSEPPDLEKSMEFSRAGEADAAQSQVIKVWSINYTFVKGVETPFIDTLEVELMSNGAKKAVMKNRTYTDVMEMDGGEDAVTEFGPISDTPIEKAEIGNMYCHRFVRLSSLVPCVWLIEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMH5</accession>
    <name>A0A0G4PMH5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclin-like F-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S023g000017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793156">
        <property type="protein sequence ID" value="CRL27559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PMH5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL27559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="88" mass="10018" checksum="D9E6A9FD1DCF5567" modified="2015-09-16" version="1">MLETLPSEILMLIADWLPVTTLRVLSRASSRLYAVLVPRIYRTVSFCAASEWALNVLDVDPFFRHLGPSRAADYLQHTVTTLINSFCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMP7</accession>
    <name>A0A0G4PMP7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S022g000091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793155">
        <property type="protein sequence ID" value="CRL27411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PMP7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL27411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="148" mass="17389" checksum="C77357394B410013" modified="2015-09-16" version="1">MPNVGENDKLQEISDYVRFSSLSQQKADIRHALATEPIQYILKELADLEHDDPKSAFPAARFVGLYRRLWESCVSKHIIGQRLEQENLLLEEAGAHLRKKRDGLQLRHDKQLARLRFLEQALDSSRERLVSVLNDWTYISIRRLFCFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMX4</accession>
    <name>A0A0G4PMX4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S022g000168</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="HG793155">
        <property type="protein sequence ID" value="CRL27488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PMX4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PMX4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1300.10:FF:000003">
        <property type="entry name" value="Amidase signature enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF10">
        <property type="entry name" value="ACETAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="64"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="208"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL27488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="579" mass="63958" checksum="871D51C9C28F5F9D" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNC2</accession>
    <name>A0A0G4PNC2_PENC3</name>
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        <submittedName>
            <fullName evidence="6">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S024g000109</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793157">
        <property type="protein sequence ID" value="CRL27854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PNC2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PNC2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039297">
        <property type="entry name" value="COX7a"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02238">
        <property type="entry name" value="COX7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL27854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="74" mass="8853" checksum="37C71BB4A56BC37C" modified="2015-09-16" version="1">MFRATSSRMAGFVFRENRVPYYQRLFQNHDGKRQWWKTSRSGYIMYPYLLSVYGLGAATTYAMCRMVLGHKTWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNQ7</accession>
    <name>A0A0G4PNQ7_PENC3</name>
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        <submittedName>
            <fullName evidence="12">Metalloenzyme, LuxS/M16 peptidase-like, metal-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S025g000048</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793158">
        <property type="protein sequence ID" value="CRL27990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PNQ7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PNQ7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000003">
        <property type="entry name" value="Insulin-degrading enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000005">
        <property type="entry name" value="nardilysin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="8">
        <location>
            <begin position="102"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="9">
        <location>
            <begin position="299"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="10">
        <location>
            <begin position="483"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme PQQ synthesis protein F-like C-terminal lobe" evidence="11">
        <location>
            <begin position="877"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="182"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL27990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1175" mass="133406" checksum="3C0E452EC436F4BE" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNV4</accession>
    <name>A0A0G4PNV4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S024g000083</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasmic vesicle membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
            <orientation evidence="1 6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="6">Cytoplasmic face of coated pits and vesicles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the clathrin light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793157">
        <property type="protein sequence ID" value="CRL27828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PNV4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PNV4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000996">
        <property type="entry name" value="Clathrin_L-chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639:SF7">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01086">
        <property type="entry name" value="Clathrin_lg_ch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="107"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL27828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="305" mass="32881" checksum="2ECDAFDD40BF7FB7" modified="2015-09-16" version="1">MDKLTAPEPAEQRASEPAPATPVNTTSSNYQLPGPLITSPPDHLLDSNVFIESYNNQEQSIPSMADRFPSLEDFSEGQTEVADIQATTDDDFLARERAVLGEDAEQFATSQDHVAGGNVGAGDDDLLGGGDEPVEEIGQFESSFPSVATQNQNERVAPGGTITGSGSPFPRTGYQSTPQEPEDEGDAVREWREKRDAEITRRAEISAEKKDNTVKKAQEDIDDFYVSYNNKADKNRSHARAEAEQFLANREDTSAGGTSWERIAKLVDVSGKGSAGGASGSGKERFRELLIDLRKDQEAPGASGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPB2</accession>
    <name>A0A0G4PPB2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S026g000090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793159">
        <property type="protein sequence ID" value="CRL28225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PPB2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PPB2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL28225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="246" mass="27919" checksum="304A865FBC06F042" modified="2015-09-16" version="1">MRLYLGPEYGIGTEDIFYTEVQLHSLQPGTQVSLISSVDADICSMNPNLILRVQQIISVDRHKRYLLYRCPRPSAKRSMIPPHSITICSHETNRDIVTWVNQVVSTHRAGEKAPSVSFACRHCGTDALLEMVDFENQLALVITKWIGLGAGLTPEDPQWRIHQKLGFSPMRSTEGEYTKNSTKASARACFERASTENLRSRNMAYLKDQRFKNCMIYNPLPSFGGYDPNTWYLWGNHSKAARPATH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPE3</accession>
    <name>A0A0G4PPE3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S026g000114</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793159">
        <property type="protein sequence ID" value="CRL28249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PPE3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF16">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="6"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL28249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="508" mass="57438" checksum="FECC196D7B9C1261" modified="2015-09-16" version="1">MRPAKACATCRERRRKCDIPAPGRSCSYCSARGLFCTRKHLPVPKGSSTPEESTAGTVSLPEKCTLPDQPLCTELVELYFDYVHDKFHSLFHRPSLIEDIRRGQVPENLVYGILALSARFSNHISFADTDPRERGKGYTKRCEELLNLNDVSLTTIQVCVLLGAIAVVNGNPASETIYYSIACRIAQLLDLPNCRASSRVEQEVNTRVWWTLCMIDVWSSAGVRLPRLMTPQPNVPLPMNEATFLAMTRTQGFTVLVSNDRASSLLAQMVLLNRILLEINDFNTKAAETTLTEEYITITLSDLSAKLSTWLKNLPAHMHDTPSNLQSYASQGQGHLFVTLYLGYYHYGQMLFYRFLHEDVRGHTPCTHFYAQQCKEHAVRLCEMIYRSEEVPGCAVLYNMVGHVLVIASTVQIHTLLFGDEASVVRARARLERNFCILTKLRALWPTLDVCMERLQAFHRACRSSVDTSFRMDRWMVRFLVEFANPVRDKEGGGGVEVPWALEEIGIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQE2</accession>
    <name>A0A0G4PQE2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATPase, F0/V0 complex, subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S029g000031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793162">
        <property type="protein sequence ID" value="CRL28615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQE2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL28615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="50" mass="5479" checksum="EDF3A19B12131FB8" modified="2015-09-16" version="1">MADSELAPKFAPFFSFAGIAAAVKRQEQLMEQRSLALELQAWEPIGPISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQF5</accession>
    <name>A0A0G4PQF5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S029g000051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793162">
        <property type="protein sequence ID" value="CRL28635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQF5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL28635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="77" mass="8442" checksum="767DDDEC022B416A" modified="2015-09-16" version="1">MVDSQRASPTDRQRRRLFVPTHPEIASVSDSSSLEEVWKMDPIEARAVWSHEVVFGGAGAEGVFDGCIVELGEGLGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQH0</accession>
    <name>A0A0G4PQH0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine-protein kinase STK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S029g000066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793162">
        <property type="protein sequence ID" value="CRL28650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQH0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PQH0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053083">
        <property type="entry name" value="TF_kinase-domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44305">
        <property type="entry name" value="SI:DKEY-192D15.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44305:SF24">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE C03B1.5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="170"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL28650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="941" mass="106536" checksum="C84D13E724BA51B1" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQI8</accession>
    <name>A0A0G4PQI8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="14">SecY protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S029g000086</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793162">
        <property type="protein sequence ID" value="CRL28670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQI8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PQI8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3370.10:FF:000002">
        <property type="entry name" value="Transport Sec61 subunit alpha isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="entry name" value="SecY subunit domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006341">
        <property type="entry name" value="PRK08568.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="SECY/SEC61-ALPHA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="Preprotein translocase SecY subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Translocon Sec61/SecY plug" evidence="13">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CRL28670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="478" mass="52206" checksum="B32A7BBC4B389D7B" modified="2015-09-16" version="1">MSGLRFLDLIKPFTPLLPEVAAPETKVPFNQKLMWTGLTLMIFLVMSQMPLYGIVSSDTSDPLYWLRMMLASNRGTLMELGITPIISSGMVFQLLAGTHLIDVNLDLKTDRELYQTAQKLFAIILSFGQACVYVLTGLYGQPSDLGAGICVLLIVQLVVAGLVVILLDELLQKGYGLGSGISLFIATNICESIVWKAFSPTTINTGRGPEFEGAIIALFHLLLTWPDKQRALYEAFYRQNLPNVMNLLATLLVFAAVIYLQGFRVEIPVKSSRQRGMRGSYPVRLFYTSNMPIMLQSALCSNIFLISQMLYSRFSENILVQLLGVWEPREGSAQLYAASGIAYYMSPPLNFKEALLDPIHTAVYITFMLVACALFSKTWIEVSGSAPRDVAKQLKDQGLVMSGHREQSMYKELKRVIPTAAAFGGACIGGLSVASDLMGALGSGTGILLAVTIIYGYFEIAAREGDIGAGLKGLVPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQW1</accession>
    <name>A0A0G4PQW1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S030g000086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793163">
        <property type="protein sequence ID" value="CRL28799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQW1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL28799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="139" mass="15841" checksum="B59F5E766FE73014" modified="2015-09-16" version="1">MARRKRIRTEQSLPTEEKSHATECDDQQMMERRSKEIDYKMSSMPPSKLPNLIKRLSWAIERTDKLCSPPPNLESNADDGNPSRDFGITHQPRKSDPDLYRADSKSGPGDWISQRTSIGSSIYKGLMAWESWGGQCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQZ5</accession>
    <name>A0A0G4PQZ5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP synthase subunit 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Lipid-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PCAMFM013_S029g000014</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the ATPase C chain family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793162">
        <property type="protein sequence ID" value="CRL28598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQZ5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PQZ5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033177">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, proton-transporting domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18182">
        <property type="entry name" value="ATP-synt_Fo_c_ATP5G3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.20.10:FF:000006">
        <property type="entry name" value="ATP synthase subunit 9, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="ATP SYNTHASE LIPID-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031:SF13">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0138">CF(0)</keyword>
    <keyword evidence="9 17" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="12 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 17" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 17" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="18">
        <location>
            <begin position="85"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CRL28598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="150" mass="15865" checksum="1AD43FFD1CE3A53D" modified="2015-09-16" version="1">MAATRVFTSRMASVMAQTSKVARPAARFQLNAATKRTFTQKAPAFGAPKRIQSPTLLQAKAFQTAARRQYSSEVASAMVEVSKNIGMGSAAIGLGGAGIGIGLVFAALLMSVSRNPALRGQLFSYAILGFAFVEAMGLFDLMVAMMCKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRY5</accession>
    <name>A0A0G4PRY5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">AP-3 complex subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S031g000004</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Adaptor protein complex 3 (AP-3) is a heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793164">
        <property type="protein sequence ID" value="CRL28836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PRY5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PRY5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030665">
        <property type="term" value="C:clathrin-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000251">
        <property type="entry name" value="AP-3 complex subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017105">
        <property type="entry name" value="AP3_complex_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781:SF12">
        <property type="entry name" value="AP-3 COMPLEX SUBUNIT DELTA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781">
        <property type="entry name" value="DELTA ADAPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037092">
        <property type="entry name" value="AP3_complex_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="10">
        <location>
            <begin position="3"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="710"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="763"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="820"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="855"/>
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        </location>
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            <end position="922"/>
        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL28836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="922" mass="102352" checksum="036C7B17FE687B7B" modified="2015-09-16" version="1"> </sequence>
</entry>
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    <accession>A0A0G4PSK0</accession>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
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    </dbReference>
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            <dbReference type="EMBL" id="CRL29163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="791" mass="89638" checksum="3827D7839093A77C" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Lacoste S."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="12">
        <location>
            <begin position="5"/>
            <end position="142"/>
        </location>
    </feature>
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        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <location>
            <position position="61"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <location>
            <position position="89"/>
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        <ligand>
            <name>ATP</name>
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        </ligand>
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        <location>
            <position position="95"/>
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        <ligand>
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        </ligand>
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        <location>
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        <ligand>
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        </ligand>
    </feature>
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        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL29464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="153" mass="16619" checksum="60072A7B862D3428" modified="2015-09-16" version="1">MSANEEQTFIAIKPDGVQRGLIGPIISRFENRGFKLVAMKLTSPSQDHLEKHYADLATKPFFKGLVAYMLSGPICAMVWEGKDAVKTGRVLLGATNPLASAPGTIRGDFAIDVGRNVCHGSDSVENAKKEIALWFGASEVLKYTSAQSAWVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PSQ6</accession>
    <name>A0A0G4PSQ6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D111/G-patch</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793168">
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    </dbReference>
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        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GPANK1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20923">
        <property type="entry name" value="BAT4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20923:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="164"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL29407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="268" mass="28883" checksum="5FD5EB7538BD51F0" modified="2015-09-16" version="1">MASEDEDYFLPPEQQRPFSSGIRRKPVQFVRSSDLDTTTAPTPSSSSGTSIADKYLSIVMGQPAASTSPSTPTQRASSPPIRTHSAPPTQDMTQDIIPPPPPIGPAPAPAPASAPVASEYCEVCKLPIPKATADATDQNPRPHESSLAHQICLTHSHPPSHLDRTRSGLRYLSTYGWDPDSRLGLGASGREGIREPIKPRAKHGTAGLGTGLDRDGDPLPPKPPPVKVQKLNAKQVRNKIAEDKKRAERIRKAFYQNDEVLKYLGEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PT81</accession>
    <name>A0A0G4PT81_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S038g000025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793171">
        <property type="protein sequence ID" value="CRL29622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PT81"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL29622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="89" mass="10300" checksum="BF23B6B04E5F7B2C" modified="2015-09-16" version="1">MRRKDINVNMRFCSNCEEDLRLCALLLALQILKDFLHGCPYRARAYLLALLHGPTWHSPTTHEGFDLEKHGHTYVVHPSIWPLLHSPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PTM2</accession>
    <name>A0A0G4PTM2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S039g000015</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793172">
        <property type="protein sequence ID" value="CRL29706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PTM2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015233">
        <property type="term" value="F:pantothenate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098717">
        <property type="term" value="P:pantothenate import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF4">
        <property type="entry name" value="PANTOTHENATE TRANSPORTER FEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="32"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL29706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="476" mass="53539" checksum="A491C02C451D1CE1" modified="2015-09-16" version="1">MFIFSKLREVVWGKPAATKAERRLLVKLDLVILSFCCLMYWVNYLDRMNLNNAYVTGMREDLNFRGNQLNIANTVFYGGYVLGQIPNNLALQKLPPRIYFPACMVAWGLLTLGTGFTHHPWQIMVIRFFQAIFEASTFVGCQYILGSWYKPDELGKRTAIFTSSGLAGTMFSGFMQGGIHQSLDGVRGLPGWRWLFILDFCITIPVAIFGFLAFPDTPTSTTAWWLSEEERKLAIERLPEVEKQRGVLGWNLISRVLRTWHWLGFILLWIFASNTEMFSSNAIMNLWLSSTNNYTVSQVNYIPTGVAGVGIITTLILGWYSDFTKRPWHISVFLAFTAILSGAIMLRPPSTGAKFFALFLNGSQYASQTVIFAWANGATGDDDAKRGIILGAMNTFSIAVYMFWSILFYSTTQGPDWKEGSIAMICMGLALAITTIGVWYMEKRDKRRIGVHDGVQANGTDEVKASIDADRPKGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PU91</accession>
    <name>A0A0G4PU91_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S044g000006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793177">
        <property type="protein sequence ID" value="CRL30075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PU91"/>
    <dbReference type="STRING" id="1429867.A0A0G4PU91"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL30075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="129" mass="15211" checksum="D8F8E938B5634B27" modified="2015-09-16" version="1">MYLHPAAHQDLENPLGLPIYECWFCPTNWIGFSGLLYHLEEGRCVKRDRIRTLAFETPEYGFYGNKLTDENPFFCFQCRTQFPQVSHLYHHVEQNPSCSYLLNPSECLGALRDFYIEYYECPGGDYISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUS2</accession>
    <name>A0A0G4PUS2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S047g000003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793180">
        <property type="protein sequence ID" value="CRL30275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PUS2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="121" mass="12988" checksum="4D856292154A8947" modified="2015-09-16" version="1">MGGKKHICSKCRSRKAKPSTSFAPEPEPGPEHVENNVESPEAIEAEVEYPIQSSEAIGSGISESKDLLEGPYEDDNSSGFVLDTPQSEATVRSAQHDDVACMRVNYSHVCLVLPVSGSLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUS5</accession>
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            <fullName evidence="7">Amino acid/polyamine transporter I</fullName>
        </submittedName>
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        <name evidence="7" type="ORF">PCAMFM013_S044g000022</name>
    </gene>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793177">
        <property type="protein sequence ID" value="CRL30091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PUS5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PUS5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF512">
        <property type="entry name" value="SOBREMESA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="513"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="549"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="575"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL30091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="613" mass="65473" checksum="279483F3D3FC0259" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PV57</accession>
    <name>A0A0G4PV57_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GTPase effector domain, GED</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PCAMFM013_S046g000035</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793179">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PV57"/>
    <dbReference type="STRING" id="1429867.A0A0G4PV57"/>
    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GED" evidence="1">
        <location>
            <begin position="88"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="178" mass="20620" checksum="D34CE8011D0414F5" modified="2015-09-16" version="1">MREKLRRIISSREQETYSQAHEQLLKILKDERGGILQTVNHYYADNLSSIRQERVMTRLKTLGLHDRILFNMDRVLQGVYLSNEDQAIFDIHDILKAYYKVAMKRFTDNIVVQVSERYILGDRGPVKMFSPDIVGDFEDDKLIEIAGENFATASQRNDLVSKAARFKQALQIAKQAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVY8</accession>
    <name>A0A0G4PVY8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S052g000043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793185">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
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    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="27"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="246" mass="27469" checksum="B31DACF2717AD373" modified="2015-09-16" version="1">MSTTTMEDPLHTPEVITIIPSSPAPSYRIETFTQSDLLKQPFLPELRDIINISYYDTAGTSFVKSGPRLMSDTQLAEELEETGFTAIAFAENAIIGTASLKVCSPDSEGPPWKLPGHFEQFSADEIFSGSSTVLDSLHDESQNAHCEEVFELVAVAITPDPRYRRKGIGESLAKACEDELKRRMSLAACTGLSRSCMMLRSVREIRGAYWLKRGFRVVGEQYCPPLTWGYSKGRPILFFTRKLELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PW54</accession>
    <name>A0A0G4PW54_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S048g000064</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793181">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PW54"/>
    <dbReference type="STRING" id="1429867.A0A0G4PW54"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="224" mass="24507" checksum="3BBD5BD30FFC8575" modified="2015-09-16" version="1">MTGKMGSERIALPAMKSALVPFRPAENVTPALSRASQIDDPIETTYVRMLREEAEMDISFNITVGMANWALLAGYLVIPGTFTSLQTSNQVEKALQVNKAGRTVLHTIQNPPLLGIACLLLVSGIGALMWLMHFPKLRGNYLWLVNKLFVPLCLNAAAGLLTTVINVCTSQGGDWSVMAIVTTAVTGATLSICSALLAIYKFYKLEEIIKEDEYIRRFRAAISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PWF3</accession>
    <name>A0A0G4PWF3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S052g000014</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793185">
        <property type="protein sequence ID" value="CRL30457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PWF3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PWF3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF224">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL30457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="407" mass="44110" checksum="3789818A62C74804" modified="2015-09-16" version="1">MNLFKSTGDADQNVFDEQKSVHEAGDSGVVTPVNESETTSDKLINDASNFPDGGTKAWLNVVEGSCIFFSMFGWANAFGVFQSYYQEHQLKDYTAFQISWISSIQTFILFGGGIVAGKLYDNYGPQVLVYPGVFLHLFGMMMCSISTEYYQFILSQGVCTSLGDAALFTASLSTASTWFHKKRAFAFGILLTGTSIGGVAMPICLEHLLNSLGFDWAIRVCTFINLALLVIALPTVTSRLPPTPKPVSVMDHIRPLKEGPFLMLSGGCALFYLGMYLPFNYIIVQAEYEGMPAGLAGYLIPILNGASLFGRLIPGKIADIIGRFNTMMPYVALPVDIREIGVRSGTLWLTVGIAALVASPIGGALEVRDGGAFVGLQIFAGVTMLIGTALFVVGRWYLAGWNFFAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PWT8</accession>
    <name>A0A0G4PWT8_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mannosyl-oligosaccharide 1,2-alpha-mannosidase</fullName>
            <ecNumber evidence="4">3.2.1.113</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S056g000033</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.113" evidence="4"/>
    <dbReference type="EMBL" id="HG793189">
        <property type="protein sequence ID" value="CRL30660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PWT8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PWT8"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF101">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL30660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="118" mass="13374" checksum="EDE7E19E5B27942E" modified="2015-09-16" version="1">MATNRKKVPSDQKKFYEKTGFYINSGAYVQRPEVIESFYYAHRYRDSVWNALVAINATCRTDSGFAAVSNVNQANGGSKYDNKGELHFRQDAAWQVQEGNKNTFVFNTEAHPISVVPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PX38</accession>
    <name>A0A0G4PX38_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S070g000011</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793203">
        <property type="protein sequence ID" value="CRL31062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PX38"/>
    <dbReference type="STRING" id="1429867.A0A0G4PX38"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF16">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL31062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="128" mass="13580" checksum="FBAC86CE53D51796" modified="2015-09-16" version="1">MFAITKYALPFMSKGDSIINNASVVTFRGSSSMVDYASTKGAIVGFTRSLALQLAPKGIRVNAVAPGAIYTPIQVDTRDPNSMAGWGSNKQLGRPGQPSEVAPSFVFLASKDATFYSGQILHCYPLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PXC2</accession>
    <name>A0A0G4PXC2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S081g000012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793212">
        <property type="protein sequence ID" value="CRL31153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PXC2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL31153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="81" mass="8875" checksum="644817EDC3F7DB62" modified="2015-09-16" version="1">MQISAETHGTVDQGGSICGEKMETIAKVQTRSTSPKLAAVSVRWNGGLLPRRYCWGSYNPIRGCVLGRSHEKNYANYGQTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PXP1</accession>
    <name>A0A0G4PXP1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S062g000033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793195">
        <property type="protein sequence ID" value="CRL30894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PXP1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PXP1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005196028" evidence="1">
        <location>
            <begin position="18"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="94" mass="10429" checksum="0EB1E359546F786E" modified="2015-09-16" version="1">MKVILSACALFVSLCAAANCQSGLDYCAFTLMGKGNYHQEIYDALKHADWPIDPMLVNFDYYLYRCHDDGTISKTENCPYGCVDGGDNSSDHCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PXV4</accession>
    <name>A0A0G4PXV4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S067g000009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793200">
        <property type="protein sequence ID" value="CRL31001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PXV4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL31001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="62" mass="6919" checksum="E57FC42FFC440BFD" modified="2015-09-16" version="1">MPNPDPLQPPVTPAERKIINEFGGWLKFMACYGLDPLEQDEATEGKEVLEAMVKQNSMMGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PY44</accession>
    <name>A0A0G4PY44_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S178g000001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793308">
        <property type="protein sequence ID" value="CRL31388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PY44"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL31388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="73" mass="8033" checksum="C76688681F8C15DA" modified="2015-09-16" version="1">MSTAMYEEMASLNNENSRRCSLPSFKLTTIMGASDVGEERRLPPLPQILPLSSPGPFNPFNTKDALIPTTPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PYH4</accession>
    <name>A0A0G4PYH4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP synthase subunit 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Lipid-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PCAMFM013_S090g000001</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the ATPase C chain family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793221">
        <property type="protein sequence ID" value="CRL31216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PYH4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PYH4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033177">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, proton-transporting domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18182">
        <property type="entry name" value="ATP-synt_Fo_c_ATP5G3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.20.10:FF:000009">
        <property type="entry name" value="ATP synthase subunit 9, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="ATP SYNTHASE LIPID-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031:SF0">
        <property type="entry name" value="ATPASE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-0138">CF(0)</keyword>
    <keyword evidence="9 16" id="KW-0375">Hydrogen ion transport</keyword>
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    <keyword evidence="12 16" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="17">
        <location>
            <begin position="8"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CRL31216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="74" mass="7522" checksum="EAD52D4C15B38F98" modified="2015-09-16" version="1">MLQSAKIIGTGMATTGLIGAGIGIGLVFGALILGVARNPSLRGPLFSYAILGFAFAEATGLFALMMAFLLLYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PYM4</accession>
    <name>A0A0G4PYM4_PENC3</name>
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        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S100g000005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793231">
        <property type="protein sequence ID" value="CRL31267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PYM4"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL31267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="102" mass="11188" checksum="C44F44E9DC87B763" modified="2015-09-16" version="1">MQGKLDQDLTTTRKALTQVTDELEQVSKLADLIYEVSQRMGAVTDYLLKEHGIQESSRGSESFEVILNSVVEKTEAQEPRKDAETVDVGSRSNVSGPAEMGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NT20</accession>
    <name>A0A0G4NT20_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S001g000187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NT20"/>
    <dbReference type="STRING" id="1429867.A0A0G4NT20"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37852:SF1">
        <property type="entry name" value="HIG1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37852">
        <property type="entry name" value="YALI0B21208P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL17227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="209" mass="23146" checksum="5C98F862F87FFC13" modified="2015-09-16" version="1">METNRPPSTNSQHNSIVLKIVHWDKLFESDSPPRLGIEFGKRLPYATLSALSTGLALGYYHGSKKAGLVFRAENAHRFPTTSTGWFQYHKTKNYIGVVGGVKDGMKMGFKLGAGALAFCLFEETVDYARHDERDFLSTVTAGLSFSGIYSLLARHDVYTAARTAKLGLKLSLTYGLLQDALETLKGNRPAYVDFFLGNRRSKVEKEGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NTW0</accession>
    <name>A0A0G4NTW0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein bS6m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S001g000496</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NTW0"/>
    <dbReference type="STRING" id="1429867.A0A0G4NTW0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15465">
        <property type="entry name" value="bS6_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.60:FF:000007">
        <property type="entry name" value="37S ribosomal protein Mrp17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_bS6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00166">
        <property type="entry name" value="S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS6M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="Ribosomal protein S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL17536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="121" mass="13673" checksum="578A7338AD3621FB" modified="2015-09-16" version="1">MLYELIAIVRPGSLNEVREIARNAGTQVIRSGGVVRGYTNWGAFRLPKVTTKHQARYTEGHHFIMRFDSSGSVQSSIRRTLGLDPRMINFSVVKLGDKLEEIKDIDGKVQWNNVSTITEQI</sequence>
</entry>
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    <accession>A0A0G4NUD0</accession>
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        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
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    </gene>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL17678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="117" mass="11264" checksum="9E56460257C3B361" modified="2015-09-16" version="1">MKFTTVIASLCLVAAPFVAAEETTTSTATTTITKTLVRVNSVTPTPSSSVSSSAASSASNLTTMSVSTSTPLSRATSTTSTAAAAATSTGAAANIGAGMPAALAAAGYIVVMVGQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NV61</accession>
    <name>A0A0G4NV61_PENC3</name>
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        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PCAMFM013_S001g000932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF32">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
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    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL17972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="248" mass="26347" checksum="EC1FF02B0205308C" modified="2015-09-16" version="1">MSQQTIILITGANSGVGYATAQILAAHPNHHVIMACRDPKKGQQALSELQSKDPKGTLSLLQLDVEDDTSIAQAVNTVSEQFNHLDILLNNAGSAAPNSSGRARLNQIFSTNVIGATLVSEAFIPLLLKSENPYLIHVSSGLGSMKLATDPSSQVYAAPWDEYRASKAALNMITVQMHKRLQSRGVRVFAFCPGLVRSNLRGEDEAAVSAHGRAGDPLEAGRGILGIVLGERDGEAGGFVNKDGPLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NV76</accession>
    <name>A0A0G4NV76_PENC3</name>
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        <submittedName>
            <fullName evidence="4">Galactose oxidase/kelch, beta-propeller</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">PCAMFM013_S001g000942</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
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    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF2">
        <property type="entry name" value="NEGATIVE REGULATOR OF SPORULATION MDS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="700"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="849"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="707"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
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            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="852"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="863"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL17982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="892" mass="95604" checksum="88446FF988E4BD03" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NVK8</accession>
    <name>A0A0G4NVK8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S001g001047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NVK8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL18087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="161" mass="16867" checksum="41CA38B876F29E0C" modified="2015-09-16" version="1">MAGREFTLSFETTPPTAAQPGSPFTIPVVIAVNPIGTPAQNVQHLVVNASLRDESGAGAAVGLSGNLTASVRSRTDNAMSGYAKLSPLTISQPGKFRLRVMLSAASYNGVVTKEYVDSTIIHVHAGAAAQRPTPTQVARLQRLTTENLDISAADIAAWQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWJ3</accession>
    <name>A0A0G4NWJ3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoacyl-tRNA synthetase, class I, conserved site</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S002g000333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWJ3"/>
    <dbReference type="STRING" id="1429867.A0A0G4NWJ3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019182">
        <property type="entry name" value="Cytochrome_b-c1_su10_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28254">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28254:SF1">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09796">
        <property type="entry name" value="QCR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL18463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="108" mass="11897" checksum="D4D1AFE98CCA3B1F" modified="2015-09-16" version="1">MTLGTAIQLGSVAAGFGVALGSGALFIFGEVPRVRNDILRKLPFFDTYYDRTIAPEDNVSQLQLIWSFGLDADFLLALLNYSPGYIPVSLDRYESRLSGVRLGLYCVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWZ0</accession>
    <name>A0A0G4NWZ0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S002g000493</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWZ0"/>
    <dbReference type="STRING" id="1429867.A0A0G4NWZ0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF1">
        <property type="entry name" value="CIPA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="13"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL18623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="320" mass="34460" checksum="F37AE3E5EC290B23" modified="2015-09-16" version="1">MEPIRNVALLGKGWLGSAILEQLMNTGFQVTVLSRTARSVDEAPSSIKTMQVDYSSIDSLVAALRGQDAVVSTVGSSGISAQKTVIDASIQAGVRRFIPSDFGALTTRPGAESLPLNALWIDIQNYLKEKALSGQIEYTLFAVGPFLEFVMSMPFLTDLQTQTAPVYDDGVHTFSSTSVSSVGKAVAGALKNAAATKNRLVSVHDIVLTQNKVLNLAKKYSGSDVKWIEDPLDAAAELETILENTKQRDLDLFKTLALLKAALLGGKFQAEFKTLDNDLVGVRLLSDDEFEEIFATAFQPGQMIAQEDLQANVEGIQGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NX99</accession>
    <name>A0A0G4NX99_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S002g000551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NX99"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL18681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="398" mass="45576" checksum="B5C027AAA25D8DCE" modified="2015-09-16" version="1">MLRCRKMLLRLLHIFWKKVPEYSSVICLGERVLQKIYQHLSLVDQVCLSLSCKELFGLFGTIVKHKDLEFPRLLRIKNPILCVNSQDVLRNQLLLRLQNHRWAYCAKCLKLHPRTEFTRHLLRQPALERFCTYYAGIVDVRPCISLTIRGRDQLVRILKSPAKPAKTKLGPLEYDFDDGGRPSLGHVCLFSTRSGYDVRVALVLFVKETGQLCVAARHTISFSSSDAHLTAEPTFACPHQDLLSLVPENQAAKDPHMYQTLISSKVHQDLLSLVPGKVVSKACPMCQTLITKYALSDDMNRAIFWVVRNPGSCEWPADRPWLDQCRLTGACFLHNEKYWYRSQNLREITQCVHGQWGRDYCLEQERRLLQHQREASRTADEGIQIAGAIPALVLAALC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYG0</accession>
    <name>A0A0G4NYG0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="3">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Nuclear thiol peroxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCAMFM013_S002g000889</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peroxiredoxin family. BCP/PrxQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="3"/>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL19019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NYG0"/>
    <dbReference type="STRING" id="1429867.A0A0G4NYG0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03017">
        <property type="entry name" value="PRX_BCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000157">
        <property type="entry name" value="DOT5p Nuclear thiol peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050924">
        <property type="entry name" value="Peroxiredoxin_BCP/PrxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801:SF23">
        <property type="entry name" value="PEROXIREDOXIN DOT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="15">
        <location>
            <begin position="34"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CRL19019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="210" mass="22540" checksum="B4D65F632F705B73" modified="2015-09-16" version="1">MVELRKRKAPAPLPVAEKKTKPAPKPKQDADATDNDIEKSPAPKVPEVDDTIDIEAFGGEFETNEGEKTTLKKLLEESKSGVVFFTYPKASTPGCTKQACLFRDNHTHLTSTGLAIYGLSGDSPKANTTFKTRQNLPYPLLCDPKATLIAAIGFKKSPKGTTRGVFAVDKKGKVLLREAGGPDATVDAVQKIVANAPSVEDTKEEGDEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYW7</accession>
    <name>A0A0G4NYW7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">GOLD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S003g000071</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NYW7"/>
    <dbReference type="STRING" id="1429867.A0A0G4NYW7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195258" evidence="9">
        <location>
            <begin position="22"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="31"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL19280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="203" mass="23569" checksum="D2945DEEED90FB96" modified="2015-09-16" version="1">MRFSTSTILVTALGWITAATAHTIQLKAHTRECFHESLHRDDVMTVTFQVGDREFGGSGNLEVDFWVEDPLRNRQYFKQAVASDDYSFTAQADGKYNYCFSNEGWTSNSKEVSFNVHGIVYVPEHEMAQDPLEVEVRKLSEALTQVKDEQSYIVVRERVHRNTAESTNGRVKWWSMFQLMVVIGEGVFQVWWLKRFFEVKRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZN6</accession>
    <name>A0A0G4NZN6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S003g000313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZN6"/>
    <dbReference type="STRING" id="1429867.A0A0G4NZN6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL19522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="201" mass="22382" checksum="EACF565688F756CB" modified="2015-09-16" version="1">MFQLNPEPVHGSESLQTAYTKMIIEFYCTPLRYNVLASTTNWVLLAGYLVIPGTFTSLQKSKSLEHKLDANDTGKTILYTIQNPPVLGIGCSFLILGALGMSALGWDRRHNYVWLINKMFIPTFLNSIAGLITTVINIYTARNGHWPIMAVLTASITAAVALASFFLILVYQFGKLERIKQDHIREINAGFQMIRGHTSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZV3</accession>
    <name>A0A0G4NZV3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger, LIM-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S003g000369</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZV3"/>
    <dbReference type="STRING" id="1429867.A0A0G4NZV3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09394">
        <property type="entry name" value="LIM1_Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09395">
        <property type="entry name" value="LIM2_Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000043">
        <property type="entry name" value="Rho GTPase activator Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000044">
        <property type="entry name" value="Rho GTPase activator Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000121">
        <property type="entry name" value="Rho GTPase activator Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF128">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN RGD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="18"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="8">
        <location>
            <begin position="874"/>
            <end position="1062"/>
        </location>
    </feature>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="579"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL20138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="596" mass="63378" checksum="62A0E6A43C533E3D" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P1I8</accession>
    <name>A0A0G4P1I8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Eukaryotic translation initiation factor SUI1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S004g000127</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Additional factor that functions in concert with eIF-2 and the initiator tRNA in directing the ribosome to the proper start site of translation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P1I8"/>
    <dbReference type="STRING" id="1429867.A0A0G4P1I8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11566">
        <property type="entry name" value="eIF1_SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000005">
        <property type="entry name" value="Sui1 translation initiation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005874">
        <property type="entry name" value="SUI1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01160">
        <property type="entry name" value="SUI1_MOF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10388">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004499">
        <property type="entry name" value="SUI1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="SUI1" evidence="6">
        <location>
            <begin position="29"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL20187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="114" mass="13041" checksum="BDCE588318D84AC6" modified="2015-09-16" version="1">MSIENLKTFDPFAEADEDTGETKQSQNYIHIRIQQRNGRKTLTTVQGLPKKFDQKKILKVIKKKFACNGTIVSDTEMGEVIQLQGDQRKDVQEFLTDKKEGLELDAKTIKVHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-11-27" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P1K1</accession>
    <name>A0A0G4P1K1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anaphase-promoting complex subunit 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cyclosome subunit 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S004g000135</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P1K1"/>
    <dbReference type="STRING" id="1429867.A0A0G4P1K1"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037679">
        <property type="entry name" value="Apc5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026000">
        <property type="entry name" value="Apc5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830:SF9">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12862">
        <property type="entry name" value="ANAPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005194964" description="Anaphase-promoting complex subunit 5" evidence="9">
        <location>
            <begin position="23"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 5" evidence="10">
        <location>
            <begin position="265"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL20195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="768" mass="87717" checksum="F7193182494932DF" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P1L4</accession>
    <name>A0A0G4P1L4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exosome complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S004g000114</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for exosome-dependent processing of pre-rRNA and small nucleolar RNA (snRNA) precursors. Involved in processing of 35S pre-rRNA at the A0, A1 and A2 sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the C1D family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P1L4"/>
    <dbReference type="STRING" id="1429867.A0A0G4P1L4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011082">
        <property type="entry name" value="Exosome-assoc_fac/DNA_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341:SF3">
        <property type="entry name" value="NUCLEAR NUCLEIC ACID-BINDING PROTEIN C1D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341">
        <property type="entry name" value="SUN-COR STEROID HORMONE RECEPTOR CO-REPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="146"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL20174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="238" mass="27000" checksum="02E7D076B07EBA6A" modified="2015-09-16" version="1">MDPTDLLPLLEQLDDNVDDLEGVLQPLLASTLLKNSNKLPVMDKAKLHVLITYTLESLIFSYLRLHGVDAKQHPVFRELTRVKQYFEKIKALETEPEERPMTLDKAAAGRFIKHGLAGNDKYDLERAEKQAKERARAEFKATMLARKSMEASKAQSSNDSDDDDSEGGVDIATTAEPQVDTNHPGKTEKDSKKKSKGEHKSEKSKSKKERKTNKATLKEEKKERRLKKEDSRKARKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P285</accession>
    <name>A0A0G4P285_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">6-O-methylguanine-DNA methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S004g000359</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = S-methyl-L-cysteinyl-[protein] + a 2'-deoxyguanosine in DNA</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="3"/>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P285"/>
    <dbReference type="STRING" id="1429867.A0A0G4P285"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10815">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10815:SF13">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding" evidence="13">
        <location>
            <begin position="54"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CRL20419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="164" mass="18009" checksum="7FB6C0A8E6F4CF18" modified="2015-09-16" version="1">MSLSTVQPADPQIATPTPDHHDPKPQKVPQPALPTAQTKKYLHRISLHPTLTPYRRRVYRTLLSVPPGRWTTYSAMATYLGSSARAVGNAMRSNPFAPEVPCHRVLAADGSLGGYKGEWKVDGHKGGGGFCEEKRLRLEEEGVVFLDGKVRGVCFKEFVDLGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2U1</accession>
    <name>A0A0G4P2U1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S004g000504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P2U1"/>
    <dbReference type="STRING" id="1429867.A0A0G4P2U1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="541"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="651"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="692"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="759"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL20563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1242" mass="136668" checksum="E4F81CFE6595AFAF" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3E7</accession>
    <name>A0A0G4P3E7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S002g000046</name>
        <name evidence="2" type="ORF">PCAMFM013_S005g000009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
            <strain evidence="2">FM013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL20845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P3E7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL18176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL20845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="27" mass="3173" checksum="4C9FEAB779F0727C" modified="2015-09-16" version="1">MPGESTIQPRYVGVAARWWWRLGGEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3F2</accession>
    <name>A0A0G4P3F2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S005g000010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL20846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P3F2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL20846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="172" mass="19853" checksum="EF2ABFF5BB7A57E6" modified="2015-09-16" version="1">MKNMFCEEDVLCRFIREYHNKKKKVDNTVYPYIYSIFYGPRYRMFAVLKHSYGRLVETKIHLGINYIDKLDFLEAYPSGSELSRNFTPKAPLPANNCVDNIYQYKALLRIGSRSPLSPSDRTFNQLIKGLPLAIQGNIILAKENSELRASNEKQKQNGSRPGSQIAFRGHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3J8</accession>
    <name>A0A0G4P3J8_PENC3</name>
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        <submittedName>
            <fullName evidence="4">FAD-linked oxidase-like, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S005g000074</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
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                <person name="Lacoste S."/>
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                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL20910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P3J8"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding oxidoreductase/transferase type 4 C-terminal" evidence="3">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL20910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="71" mass="8228" checksum="0080CDA043D88DDF" modified="2015-09-16" version="1">MVRAAREAGYGEYRAHIEHMDLVAEQYYYGGGALMRPFKRIKDTLDPNGILSPGKQGIWAKRYRNKGKWQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3N5</accession>
    <name>A0A0G4P3N5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S005g000115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL20951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P3N5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL20951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="76" mass="8536" checksum="C1C4A235D6A09181" modified="2015-09-16" version="1">MVGVFGSCPYATIASGNGDKTMNRVSDERDGQEARPVPESEHLILPRQPWKDLMLLQQYTCAHVLFNSEPFRQPCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3U1</accession>
    <name>A0A0G4P3U1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">glucose oxidase</fullName>
            <ecNumber evidence="14">1.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PCAMFM013_S005g000123</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>beta-D-glucose + O2 = D-glucono-1,5-lactone + H2O2</text>
            <dbReference type="Rhea" id="RHEA:11428"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16217"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.1.3.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:11429"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
            <location evidence="4">Extracellular space</location>
            <location evidence="4">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.4" evidence="14"/>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL20959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P3U1"/>
    <dbReference type="STRING" id="1429867.A0A0G4P3U1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046562">
        <property type="term" value="F:beta-D-glucose oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.450.10">
        <property type="entry name" value="Glucose Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027424">
        <property type="entry name" value="Glucose_Oxidase_domain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="11 16 17" id="KW-0274">FAD</keyword>
    <keyword evidence="10 17" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0964">Secreted</keyword>
    <keyword evidence="18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195144" description="glucose oxidase" evidence="18">
        <location>
            <begin position="17"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="19">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="20">
        <location>
            <begin position="310"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="536"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="579"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="569"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CRL20959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="604" mass="66229" checksum="6EEA0C96633C5A5D" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3X0</accession>
    <name>A0A0G4P3X0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ran-interacting Mog1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S005g000184</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MOG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P3X0"/>
    <dbReference type="STRING" id="1429867.A0A0G4P3X0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.10">
        <property type="entry name" value="Mog1/PsbP, alpha/beta/alpha sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007681">
        <property type="entry name" value="Mog1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016123">
        <property type="entry name" value="Mog1/PsbP_a/b/a-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837:SF0">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04603">
        <property type="entry name" value="Mog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55724">
        <property type="entry name" value="Mog1p/PsbP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL21020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="249" mass="26353" checksum="608A2145F0A69ED5" modified="2015-09-16" version="1">MSQFTEQDFFGGAIRGVVPQGWIDSSTLREVPDHQELWLSPTTLSNLIIEINQRVPQAEALNTFAALNHQQPTAAPGSGSAASATAETVDQAAALYHLHDLCDEGDTMQVITSPTRVEVQLASSSPTPASAIKAYRGVVSFTTPVRGSGGRVPASVDGSAAGVADAGVLGAQTNGDSNGLPQVSRLTCHFLLVRLEAQETDLLVFFNVPHEEFDKSGDPRGLSLEEVVAEETIGALIGRLEICDWGLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P4C6</accession>
    <name>A0A0G4P4C6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CDR ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S005g000302</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4P4C6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003632">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="510"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="546"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="589"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="624"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="656"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="764"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1187"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1219"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1262"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1308"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1339"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1458"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="148"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="842"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL21138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1490" mass="167687" checksum="86D0509F5ACF7C98" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P4I5</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <dbReference type="EMBL" id="CRL21224.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="201" mass="22059" checksum="4FA1463CA121460C" modified="2015-09-16" version="1">MTFREKVKRVFRSSKKDGKPKIEYYRRHECPPSKFRGPFDRAHQKSLAAWSFQGAMVERTRSFEISVSPCATYEGSDGYSGPSDSDNSVSPDDIDPAASHPEAPAESSPRGPDSGSQSSTVVDPASYNGSMMTLINEGSIYEIPEDAKDPKFFLKESIRYSSPLVHAISPAMTPCVMSARKDLPFAPEDLTRALIAVQVCA</sequence>
</entry>
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        </submittedName>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">FM 013</strain>
        </source>
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            <end position="288"/>
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            <end position="16"/>
        </location>
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            <end position="55"/>
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            <end position="194"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL21257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="540" mass="58969" checksum="8F27C3093D71D40F" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="8">Sucrose/H+ symporter, plant</fullName>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        <property type="entry name" value="MFS multidrug transporter, putative"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
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            <end position="227"/>
        </location>
    </feature>
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            <end position="250"/>
        </location>
    </feature>
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            <end position="324"/>
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    </feature>
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            <end position="363"/>
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            <end position="509"/>
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            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
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            <begin position="548"/>
            <end position="557"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL21406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="557" mass="63116" checksum="2C671C42139F9EB3" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5T1</accession>
    <name>A0A0G4P5T1_PENC3</name>
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        <recommendedName>
            <fullName evidence="11">Lon protease homolog, mitochondrial</fullName>
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        </recommendedName>
    </protein>
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        <name evidence="11" type="primary">PIM1</name>
        <name evidence="17" type="ORF">PCAMFM013_S006g000192</name>
    </gene>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
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    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>Hydrolysis of proteins in presence of ATP.</text>
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        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homohexamer or homoheptamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 12 13">Belongs to the peptidase S16 family.</text>
    </comment>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141164">
        <property type="term" value="P:mitochondrial protein quality control"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070407">
        <property type="term" value="P:oxidation-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19500">
        <property type="entry name" value="RecA-like_Lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000021">
        <property type="entry name" value="Lon protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000113">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.5270:FF:000001">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1480:FF:000003">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.40:FF:000006">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000015">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03120">
        <property type="entry name" value="lonm_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054594">
        <property type="entry name" value="Lon_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027503">
        <property type="entry name" value="Lonm_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718">
        <property type="entry name" value="LON PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718:SF2">
        <property type="entry name" value="LON PROTEASE HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22667">
        <property type="entry name" value="Lon_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 11 12" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="16">
        <location>
            <begin position="203"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="15">
        <location>
            <begin position="903"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="39"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="301"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="833"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="65"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="177"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="840"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="active site" evidence="11 12">
        <location>
            <position position="995"/>
        </location>
    </feature>
    <feature type="active site" evidence="11 12">
        <location>
            <position position="1038"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="614"/>
            <end position="621"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CRL21652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1116" mass="122719" checksum="297CACDCA0386A8A" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P609</accession>
    <name>A0A0G4P609_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S006g000305</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of a tri-snRNP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNUT3 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CRL21765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P609"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013957">
        <property type="entry name" value="SNRNP27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077">
        <property type="entry name" value="U4/U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077:SF1">
        <property type="entry name" value="U4_U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08648">
        <property type="entry name" value="SNRNP27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein" evidence="9">
        <location>
            <begin position="177"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="20"/>
            <end position="51"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="57"/>
            <end position="103"/>
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    </feature>
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        <location>
            <begin position="134"/>
            <end position="149"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003632"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008218"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011825"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL21765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="232" mass="27548" checksum="F341AC75EE216486" modified="2015-09-16" version="1">MAEPPAKRPRRVDSSTMWDSNDKRARAPDQESDRDRRRSPAPRDDRRDGRYRSRSRERKDGRRERSWSRDRRDRDRRDGDRDGRGAQDRKRSTSRERNQDRRGNAPKNVKFRERSRTRSPHRNGTKARSPPRGPKGDRKDPRSRDDGRKATGAQRGPGRDEDEMDVDFKEDADEDEMEAQMRKTMGFSRFRTTKNTKIPGNDIYGVRKEKKIEYRQYMNRQGGFNRPLSPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P629</accession>
    <name>A0A0G4P629_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N1221-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S006g000297</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
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            <dbReference type="PubMed" id="24407037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="294" mass="34342" checksum="9767CD6E47681559" modified="2015-09-16" version="1">MSSNMAPDNKRIELIQMSQQAAIRKPQDDWTGVIDRTERRKLQNRLNQRTYRMRRQNRNTEDKGQPHSNEAVVVPSSSTPIQIDRDETGFTCTIAPPQVYSMMRQFESLALESFIRNSPDIDHLLSLSRLNIQRAVTENTRLIGMTMEWMQDDDAISIFNTPVLTFSVSAIPPSLRPTEFQRRIPHHPWLDFFPFHNMRDNLIALQELIDDEDLCHDLMAFWDTRNTGATLLVWGPSWEPENWEVTPAFLLKWGFLLKGCEELVMNSNRWRAKRGEKPLDWKTTLALIYRSPSE</sequence>
</entry>
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="568"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="419"/>
            <end position="446"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL21934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="590" mass="67097" checksum="F11F420A7106DB07" modified="2015-09-16" version="1"> </sequence>
</entry>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Dupont J."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL22070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
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        </source>
    </evidence>
    <sequence length="575" mass="65848" checksum="F0FE340539DE8574" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7J0</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
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                <person name="Conseiller E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="53"/>
            <end position="343"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
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        </source>
    </evidence>
    <sequence length="351" mass="39542" checksum="7F3B0469A53EE8A0" modified="2015-09-16" version="1">MYSVISPNLSAARSSSARRMSSLTPGHVLRGAYWNYRVLEPVKGDNTHISTVFKAQVVLRDAHFAEVPEVPEWALIKVALPSDENATKNMQREVLTYRLAGVASAKCFRKMYDVIDDSTIALEWLDTTLAEVKYHPDMRIYSLIKTLLRAAFTSCVVLEDHKHVNTDYKPANILLSDNRTDRVIAKVGDLGLVVPVGELFNAQPYAMRAPEVFLGKACTEPSQVWAVAAMLLCWLKPGVLGAWDSPHPLINEAWSMAKIQRLFPHWEIPTPEMVKGDTLKVALNSAQSLSKQVPELQAILPFDEETKKVEMPQQLRDLLRFILVPDPKIRPSASFVLASREFRKFENYVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
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    <name>A0A0G4P7X6_PENC3</name>
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        <submittedName>
            <fullName evidence="7">Endonuclease III, iron-sulphur binding site</fullName>
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    </protein>
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    </gene>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
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    <comment type="similarity">
        <text evidence="1">Belongs to the Nth/MutY family.</text>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004035">
        <property type="entry name" value="Endouclease-III_FeS-bd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018571">
        <property type="entry name" value="Membrane_anchor_Opy2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09463">
        <property type="entry name" value="Opy2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00764">
        <property type="entry name" value="ENDONUCLEASE_III_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Membrane anchor Opy2 N-terminal" evidence="6">
        <location>
            <begin position="20"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="308"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="314"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL22431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="396" mass="41422" checksum="9105BB6ECE201F8E" modified="2015-09-16" version="1">MLLEPVDSAFSPARSLFKRCKQCETTSPACPACPDGSICSMTAPSCDECATTKCISTGSKPSNSGGSDTGAIAGGVIGGVAAIALIVFLVWWFVIRKKRLERQEAEKNGSFAANRSERQSIASTVLTRASNVIQIAYIPGVTNRSPPQTPATLVPPVPPLPGATPDQHFFMPGDLRDSSWTTTTGHQSISPTLRSSVATTIYRNDAIVSAIPAQQIQRSRAAVVSIHNGGAGQNAPGDDSPVSVTITPADAPAVPVITPAQLARAEAVKGNSSCVARSVTAKPVMVRGPSVKNKKPNNAPAVDRIEELSEHSKSNNTSRAASTTKSDQFNHNVSTFDTSSSGEDETNPSSTANLETASSHGETNARRASGLSDGRNSTRTPPDRVESPFSDANEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P8C3</accession>
    <name>A0A0G4P8C3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S007g000536</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P8C3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050114">
        <property type="entry name" value="UPF0173_UPF0282_UlaG_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43546:SF9">
        <property type="entry name" value="L-ASCORBATE-6-PHOSPHATE LACTONASE ULAG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43546">
        <property type="entry name" value="UPF0173 METAL-DEPENDENT HYDROLASE MJ1163-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL22555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="267" mass="29085" checksum="10832CF1FAD28658" modified="2015-09-16" version="1">MSPTLNITHIGTATAILEINGFNMLTDPFFSPAGSTWPINDKVSLTVEDDPALRLEQLPVIDAVLLSHEDHPDNLDELGRRLLDGRGVFTTVDGARNLSPRPAVHGLKPWEKIDTVIAGQKLQIIGTPTQHLPGGECTGFIITGEGFGTGRDGLPNAIWFSGDTVYIDELKKMADEYHICAAILNLGNAHAPANLEDPSDGLMQITMDGKSGARLFREIKADVLVPMHYESWGHFTQFGKELAEDFESEGVMDKVCWLKPGEAVSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P8I4</accession>
    <name>A0A0G4P8I4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S008g000067</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P8I4"/>
    <dbReference type="STRING" id="1429867.A0A0G4P8I4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF28">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL22638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="328" mass="35781" checksum="10F7D7ABABEAD57B" modified="2015-09-16" version="1">MSKLIVVTGATGMQGSGVIDALSANPDWKIRGLTRDTNSEKAKALVHRGIEVVAATFDDEDSLENAFIGANAIFAVTDFYEPFTKGVGPEKAMQIEYDRGVKLARAAAKTTTLETYFWSTLPAASDLSNGEVKVPHFDGKGAVDAYIKNDPVLNAKTIFLLTGFYASNFSYPPFTPVYSEPAGQHILALPAKSSSYIPSLGPVSNIGITVSGLLQHPYPKAANGCKGGRYVHVTTGKYQFQEYFSKWAEIAGKGKLQVLSVPFEQFEALYGMWGTELGLMMKFWEVAGAPKMWGTVGEGDVMIDSRELEGVKDRLVSTEDFWRQADWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P8R3</accession>
    <name>A0A0G4P8R3_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">X-Pro dipeptidyl-peptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S008g000124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P8R3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361:SF15">
        <property type="entry name" value="DUF885 FAMILY LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="GLR0591 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL22695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="562" mass="65230" checksum="9EF59CD8B7EBEDBC" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P8S0</accession>
    <name>A0A0G4P8S0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DUF221-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S008g000126</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P8S0"/>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000469">
        <property type="entry name" value="Serine/threonine-protein kinase 32B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF30">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 32B ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="385"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="500"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="385"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="446"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL23082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="556" mass="62296" checksum="7609E566E1BF532A" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PA64</accession>
    <name>A0A0G4PA64_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S009g000148</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PA64"/>
    <dbReference type="STRING" id="1429867.A0A0G4PA64"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF480">
        <property type="entry name" value="PALMITOYLTRANSFERASE SWF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="11">
        <location>
            <begin position="154"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL23208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="409" mass="46670" checksum="8017F6E4EC60FB23" modified="2015-09-16" version="1">MGALRTVGLVILAISAFTFIALFGRLPAFRKTPVAWLHRALWVYFPNGIAVVDNRLFGGRVVRGWNRSGSYVLKENHPLVLIFFTSLLVIGEGIFVPAAWPHLSSIHRLWVPVAISLPYLLLYKCVVTKSFITAENHEEEMRRYPYDRVLFHPGHECSTCKFLKPARSKHCSFCQSCVSRHDHHCVWLMNCVGANNSVYFISLLVSLSAMLIYGCYLGHSILSEMLKQAVPPEIQQAMQGWTVWINTWGIVVSAYPKIGAVFLLMLMTAPLAISFLAYHTYLIWAGVTTNESAKWSDWKDDVEDGFVFKTKRSLIFDRPLPMDLYDQLWPVHTDQILVTDEDPPTEGCLLANDSNCIAHRPESDVPPDPRWKRLQTMRDVDNIYDMGFWYNLRDVMGLSVRRSKEISGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAJ2</accession>
    <name>A0A0G4PAJ2_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Atypical Serine/threonine protein kinase BUD32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">EKC/KEOPS complex subunit bud32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S009g000261</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PAJ2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PAJ2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0779">Telomere</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="209"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="470"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CRL23321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="522" mass="59860" checksum="9BEAAA9419FA1F28" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAN4</accession>
    <name>A0A0G4PAN4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S009g000269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PAN4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056119">
        <property type="entry name" value="DUF7702"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109">
        <property type="entry name" value="UNPLACED GENOMIC SCAFFOLD UM_SCAF_CONTIG_1.265, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24800">
        <property type="entry name" value="DUF7702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7702" evidence="2">
        <location>
            <begin position="4"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL23329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="261" mass="28417" checksum="8F0776DEEA27C39E" modified="2015-09-16" version="1">MAVVGYRDGIAILQLIVFPIVLVAAIFIWKRTGWREGSKVWRYAVTLSLIRIAGSISSLLAISNDSHNIKVAVAVCQLIGIAPLLLTFIGLLRQIDVEKVMPPRSMALLTLVTLIALILGIAGVHSSSTGTDGTYHPGKLSKVAMGIFLAVFVIFVLLSVWLFYELSFSLRRFQKKLFLAIALSIPLLAVRLVYSALSDYTTLSSFALNGNTTIYLCMDVLEEIIAMGITMALGISAILEKDFVKLTPVSQEDTEPKPMGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBR5</accession>
    <name>A0A0G4PBR5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11">Glycylpeptide N-tetradecanoyltransferase</fullName>
            <ecNumber evidence="5 11">2.3.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCAMFM013_S010g000214</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>N-terminal glycyl-[protein] + tetradecanoyl-CoA = N-tetradecanoylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15521"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12667"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133050"/>
            <dbReference type="EC" id="2.3.1.97"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the NMT family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.97" evidence="5 11"/>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PBR5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PBR5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004379">
        <property type="term" value="F:glycylpeptide N-tetradecanoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000042">
        <property type="entry name" value="Glycylpeptide N-tetradecanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000056">
        <property type="entry name" value="Glycylpeptide N-tetradecanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000903">
        <property type="entry name" value="NMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022677">
        <property type="entry name" value="NMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022678">
        <property type="entry name" value="NMT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022676">
        <property type="entry name" value="NMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377:SF5">
        <property type="entry name" value="GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377">
        <property type="entry name" value="N-MYRISTOYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01233">
        <property type="entry name" value="NMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02799">
        <property type="entry name" value="NMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015892">
        <property type="entry name" value="N-myristl_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00975">
        <property type="entry name" value="NMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00976">
        <property type="entry name" value="NMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase N-terminal" evidence="14">
        <location>
            <begin position="116"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase C-terminal" evidence="15">
        <location>
            <begin position="284"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CRL23776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="501" mass="56938" checksum="994AB0CAD4C7954D" modified="2015-09-16" version="1">MSDSSDKKGKAPKRNENESGAPSDSGNESGKKIPAKFASLLLEQNPALKNELAAMDKDQAAALLHNMDLSQMLTGLAVGGKNQKDMASYKFWQTQPVPAFEEAGKKEITQGPIKVIDPEKVSKTPDALIEGFEWCTLDLTNEEELKELYELLNKHYVEDDNAMFRFNYSESFLHWALMSPGWKKEWHVGVRATKSRKLVASICGVPTELRVRGERLKVTEINFLCIHKKLRSKRLTPVLIKEITRRCYLRGIYQAIYTGGIILPTPVSSCRYYHRSLDWLKLYDVGFSPLPHGSTKARQVTKNHLPSETATPGLRPMESKDIDAVYDLLERYMRRFDMNQAFTREEIDHWLVHKKQPGKDQVVWSYVAEDPETHKITDFVSFYNLESTVIDNPKHDAVHAAYLYYYATETAFSDDKQALKERLQLLMNDALICAKNARFDVFNALTSHDNPLFLEELKFGAGDGQLHFYLYNYRAAPIGGGINEKNLPDESKMGGVGIVML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PC47</accession>
    <name>A0A0G4PC47_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pre-mRNA-splicing factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S010g000333</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Belongs to the 40S cdc5-associated complex (or cwf complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWF11 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4PC47"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17935">
        <property type="entry name" value="EEXXQc_AQR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000507">
        <property type="entry name" value="Pre-mRNA-splicing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048966">
        <property type="entry name" value="Aquarius_b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048967">
        <property type="entry name" value="Aquarius_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032174">
        <property type="entry name" value="Aquarius_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026300">
        <property type="entry name" value="CWF11_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF5">
        <property type="entry name" value="RNA HELICASE AQUARIUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16399">
        <property type="entry name" value="Aquarius_N_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21143">
        <property type="entry name" value="Aquarius_N_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21144">
        <property type="entry name" value="Aquarius_N_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038901">
        <property type="entry name" value="AQR_cwf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA helicase aquarius N-terminal" evidence="6">
        <location>
            <begin position="20"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="RNA helicase aquarius beta-barrel" evidence="7">
        <location>
            <begin position="482"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="RNA helicase aquarius insertion" evidence="8">
        <location>
            <begin position="693"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="4">
        <location>
            <begin position="794"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="5">
        <location>
            <begin position="1102"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="741"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1367"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1374"/>
            <end position="1395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR038901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL23895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1395" mass="157906" checksum="29343CC0679E9380" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCC0</accession>
    <name>A0A0G4PCC0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S010g000390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PCC0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL23952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="369" mass="41654" checksum="2720FAA60D711DDB" modified="2015-09-16" version="1">MPPKRKSTDSTASGAKKSKGPATNPEVDVETERALDKRWAPVSVSRNTDSEFRLRTRDPVNAFTYICLGCAPWKTERNEDESEDEDEEDEESIEQKKKDDAEADDATTLKPASEHPGEKWIFTNAGVAKWIMLKQGTAVRDPDNFDMHIYNDFFGYAIMELVENLFLDFDEAAGDWKMQWAICEATALYFQMDAIMPMVGCEDGDTVNEMFVAFAIMFLTMLATLKRNGLLKSDSEVKNIGAIMGLFIRFMVDVEEYGINWEGEYAYIEAYAAKHDITIHGLNHERYEKPSGETVELPEATANSNDPWGWKKTLASLKKNNDGRMGGDSKDITSWTPAERKKVAFDKKDPISRSAMTHIKNGRIMEMGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCE6</accession>
    <name>A0A0G4PCE6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Histidinol-phosphatase</fullName>
            <shortName evidence="8">HolPase</shortName>
            <ecNumber evidence="3 8">3.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S010g000382</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-histidinol phosphate + H2O = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PHP hydrolase family. HisK subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="3 8"/>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PCE6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PCE6"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12110">
        <property type="entry name" value="PHP_HisPPase_Hisj_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000059">
        <property type="entry name" value="Histidinol-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010140">
        <property type="entry name" value="Histidinol_P_phosphatase_HisJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01856">
        <property type="entry name" value="hisJ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039">
        <property type="entry name" value="HISTIDINOL PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039:SF0">
        <property type="entry name" value="HISTIDINOL-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHP" evidence="9">
        <location>
            <begin position="5"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL23944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="310" mass="35787" checksum="9ED8C79BDEE5C115" modified="2015-09-16" version="1">MPFSHHSHSGQFCPGHAQNSLEDVIQTAISKKMQVFCLTEHMPRHKEDFYPEEVESGDTEESHVKNETAYWKEAVALREKYTSQIKIIIGFEIDWIRPASKDLIDRSLSRFPFEFFIGSIHHMHTVPIDYDRPMYEEAREKAGGTDERLFEDYFDAQLDMLEQLKPLVVGHFDLIRLKSDDMERSFTTWPGVWSKILRNLDFIASYGGMLELNSAALRKGMTEPYPKAEICKEFVARKGRFCLSDDSHGVEQVALNFRPVLDFLDRAGISTLHYLQLEASVSSPVPDARFPKTQIVEISVEDVRKMAFWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCG2</accession>
    <name>A0A0G4PCG2_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chromosome segregation in meiosis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S010g000436</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Forms a fork protection complex (FPC) with TOF1 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Plays an important role in the control of DNA replication and the maintenance of replication fork stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the fork protection complex (FPC) consisting of TOF1 and CSM3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the CSM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PCG2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PCG2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012923">
        <property type="entry name" value="Csm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040038">
        <property type="entry name" value="TIPIN/Csm3/Swi3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220">
        <property type="entry name" value="TIMELESS INTERACTING-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220:SF11">
        <property type="entry name" value="TIMELESS-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07962">
        <property type="entry name" value="Swi3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0236">DNA replication inhibitor</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome segregation in meiosis protein 3" evidence="11">
        <location>
            <begin position="72"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="154"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL23998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="267" mass="29939" checksum="B39CCAA130A6BBFE" modified="2015-09-16" version="1">MANANVSERGSSPTAGDLNDLFDYDIGLDEIIPDNNAPNTNNTKASGTGDSALGLGLDEEVKVAKKRQPVAKLDEGRLLSQPGIPKLRHTARQKLKFKGKGHEFKDAARLLNFYQLWLDDLFPRAKFADGLTMIEKLGHSKRIQSMRREWIDEEKPRLFDSSGPTREDLENRDPKNPADFNHNPAAITQDQEGAADQDLFIPDPNESARPTISYPEPEDDDLDDLLREQDEPMADFPPDMHASSSRVPDDDNDDYDAEYEAMKELGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCX1</accession>
    <name>A0A0G4PCX1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Indolepyruvate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S011g000172</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PCX1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PCX1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006203">
        <property type="entry name" value="PRK08327.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF164">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="6">
        <location>
            <begin position="12"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="4">
        <location>
            <begin position="175"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="5">
        <location>
            <begin position="385"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL24178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="563" mass="60279" checksum="99FAFE61E78FF652" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PD08</accession>
    <name>A0A0G4PD08_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S011g000171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PD08"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <begin position="295"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="597" mass="67363" checksum="2B3BEAB9C25694C1" modified="2015-09-16" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CRL24398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PDJ5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000019">
        <property type="entry name" value="RNA exonuclease NEF-sp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF115">
        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Exonuclease" evidence="8">
        <location>
            <begin position="345"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="144"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="523"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="613"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="245"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL24398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="735" mass="81532" checksum="FB5028F19ADECE4C" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDJ7</accession>
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        <submittedName>
            <fullName evidence="6">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S011g000323</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793144">
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fun_TF"/>
    </dbReference>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF13">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL24329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="425" mass="48927" checksum="99ADA3DADE459EEC" modified="2015-09-16" version="1">MMDISDAKPIRARRTHQKSRLGCANCKKRRIKCDEKRPACSNCSNHLIECRYNITAESPRSQSPKCPELSTERPRRYRPHRYATGALKQTLKLSKTQPSRFTQSTGTQCSLSSGLIDTISLVDLQLLHHYTIDTYRTMTSGPDLHNVWQKHLVQWGIESPYILHLVLALSALHLAHERPDLQDQYIQQADNHFSFGVRSVASVISELNADSCQKVYMSAVMICLIYFGRGPRPGEYLIFSDSGPAEWLVLMRGVRLIVSSHHAKVFSGILEPGPNDHSRDLTAEMRIKLHEHTVHTEAVQRLIERDVADNEIRGRHLAVIQDLFEIMREVYERRSGGSSGVDLMDLLIGWFYRLPEETIGSLERKEPHSLVILAYWVVLLKYMDSAWFMDGWAEHMLSGISTYLHEDLHQWVEWPLKQVYQTRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDU7</accession>
    <name>A0A0G4PDU7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S012g000053</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PDU7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PDU7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF103">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="2">
        <location>
            <begin position="767"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL24444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1019" mass="112845" checksum="43D7825D60DF0DCE" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDW9</accession>
    <name>A0A0G4PDW9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S012g000139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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            <end position="90"/>
        </location>
    </feature>
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        <location>
            <begin position="142"/>
            <end position="186"/>
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            <begin position="207"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL24530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="258" mass="28103" checksum="43AFB54CD08A039A" modified="2015-09-16" version="1">MQQQGAEAPIPDQPGTPPRPPYSPVTPVFAHLAPVPSNEPSIVPPPASPSPTSHLPPQSYANYSHAPPPPPNPPVFKPRPPPVPISESENPDAIALRSAISILQMQKQQSLRDIQALDRMKEAAAADPEGFAHELAAGRLKTEDHGAVIQFSEDDARDDDEDEEGSKRTNPDGSPASNFGHIPVPQNIVRMPPINWAKYQVVGEPLDRMHEEQLHRPSSGEPRRTRAPEHVLASPYRPLVDQLDGPPRLGRPSKAKKT</sequence>
</entry>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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            <dbReference type="EMBL" id="CRL24589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="128" mass="14924" checksum="A0A0B2C84DD14897" modified="2015-09-16" version="1">MWRVSTHRNCSEASNVFSVCYPPVDPNSDGDIYPNRWPTDDPLIIWAFGLPFVPAYGDHYILAGPYLRNYLWILDKRDVYHQLKHAEFHLGDIISPRGKFKPINANGTVDRLRELRLVQIRERSQLAM</sequence>
</entry>
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        <submittedName>
            <fullName evidence="7">Fungal transcriptional regulatory protein, N-terminal</fullName>
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    </gene>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
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    </dbReference>
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    </dbReference>
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            <begin position="16"/>
            <end position="46"/>
        </location>
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            <end position="124"/>
        </location>
    </feature>
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        </location>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL24685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="587" mass="65252" checksum="B201550596E0FA10" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PF93</accession>
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        <recommendedName>
            <fullName evidence="3">Mannosyl transferase</fullName>
        </recommendedName>
    </protein>
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        <name evidence="1" type="ORF">PCAMFM013_S013g000214</name>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CRL24971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="48063" checksum="421C06AED0120058" modified="2015-09-16" version="1">MVMSVLESLWGTILSIPTKKVVDASLILSVCVWLVILISRKWASTTAKASSGDLEKPTAGVRGKVTRPLGEWTPSDFKRPTAAPYSGWDVHSTKPIPYRPFRYGPKYYITLGLRSMKWDEWIELDNHYLKYHVDKARRIEERGSKCCHTAPEAMDAAIELLEELCAYLPERYPNMFIKTTTGITNKVTNETFNITQRPLPEDPMATAARLVQDDLALMIERPDGEYYLLAGAILLAGFWRLSDKFGMRLSEIHTSGDVPQFKSKLEKGMMNFFRRLRPEEPVLRNNYFIQVDDNLAWSESIGSEDGETVSWNTAEKNRAIENHFFRSERQSLRRLSRSGAVVFTIRTYFEPVTAIVEEPYVPGRLADAVRSWGDDVSRYKGKEKYQDVLLEFLDEKHRMQVEGGLEVEKEDEVRRYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGI0</accession>
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        <submittedName>
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        <name evidence="3" type="ORF">PCAMFM013_S002g000702</name>
        <name evidence="4" type="ORF">PCAMFM013_S015g000035</name>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
            <strain evidence="4">FM013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="CRL25449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PGI0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PGI0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL18832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL25449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="76" mass="8544" checksum="F8657B69B43CCD7C" modified="2015-09-16" version="1">MPPIRSQSSSNSTEQEGRLLLAIQAIKKQEIRTIAAAARTFNIPRSTLRDRLNGHTERSTVRANSHKLTETEEESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGS1</accession>
    <name>A0A0G4PGS1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Acyl-CoA dehydrogenase, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCAMFM013_S015g000043</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 11 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793148">
        <property type="protein sequence ID" value="CRL25457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PGS1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PGS1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008470">
        <property type="term" value="F:3-methylbutanoyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01156">
        <property type="entry name" value="IVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000021">
        <property type="entry name" value="Isovaleryl-CoA dehydrogenase IvdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000003">
        <property type="entry name" value="isovaleryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000004">
        <property type="entry name" value="Isovaleryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034183">
        <property type="entry name" value="IVD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF18">
        <property type="entry name" value="ISOVALERYL-COENZYME A DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016578">
        <property type="entry name" value="HsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11 12" id="KW-0274">FAD</keyword>
    <keyword evidence="4 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="15">
        <location>
            <begin position="46"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="14">
        <location>
            <begin position="162"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="13">
        <location>
            <begin position="269"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="196"/>
            <end position="198"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="218"/>
            <end position="219"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="280"/>
            <end position="283"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="383"/>
            <end position="387"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="410"/>
            <end position="411"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="412"/>
            <end position="414"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634183-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634183-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR634183-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CRL25457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="429" mass="46631" checksum="A5BFE83288EAEB23" modified="2015-09-16" version="1">MASLTLPSLLRTSTRAVRLNRIPALTPCFRSISTKHPTGFAPPSEDELLELRERVQDFTRREIPADVAARTDEQNEFPAEMWKKMGDAGFLGVTANEEYGGLGMGYQAHCVVMEEISRASGSIGLSYAAHSQLCVNQLSLNGSTEQKERILPGLLSGEKVGALAMSEHSAGSDVVSMKTTAKEVDGGWLLNGTKMWITNGPDADYIVVYAKTEPELGSKGITAFIVEKSFKGFSCARKLDKLGMRGSNTGELIFEDVFVPRENLLGELNRGVRVLMEGLDLERLVLSAGPLGIMQAALDLVLPYTHVRKQFGTPIAHNQLIQGKLADMYTKLAASRAYTYATARQVDNAAVEPGELTVRTQDCAGAILYAAERATECTLDAIQLMGGSGYINEIPAGRLLRDAKLYEIGAGTSEIRRMVIGRAFNKEYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGX1</accession>
    <name>A0A0G4PGX1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pyridoxal phosphate-dependent transferase, major domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S015g000066</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793148">
        <property type="protein sequence ID" value="CRL25480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PGX1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PGX1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF77">
        <property type="entry name" value="8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="5">
        <location>
            <begin position="58"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL25480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="468" mass="51739" checksum="8FDD4352E5A5CB73" modified="2015-09-16" version="1">MSVIALLSDWIKSQKIKGPQMKDAPTFYRNLEEALDLRRADHSMFTNHKSAWKLGTSIDFCSNDMLSLGTTGEIRRTFLDELAANPNFAMYSGGSRLMDGNYDYIEDVEAEIAEFHGSETALIVGSGYEANTAIYGAVPRPGDAIVYDELVHASTHDGMTHSLAQCRIQFRHNDVDALRDAISSVLDSQPMIADGSRSLLISVESVYSMDGDICPLLEMLEVAKEMCPLGNAVFIVDEAHATGILGPKGAGLVSQLGVEKDVAIRLHTCGKALASTGGNRYPRKCDSSLCHYELRPLRHLHNCTLLPHCCGNPSGIQHDDHRKNPEVPRQPSTRSEAFFKSIEANKHWSKASEMGILSIPVIEDWAERDFNAHIVPLKTRQRYNWWLVFHLQLAGISAFPIDYPTVPRGQSRIRLMFHAANTEEQVETLASAICSWAAEMIEIEEGAEGAKKMPKAAHQVYALMAANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PHV2</accession>
    <name>A0A0G4PHV2_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S016g000218</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="HG793149">
        <property type="protein sequence ID" value="CRL25937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PHV2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PHV2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05574">
        <property type="entry name" value="STKc_phototropin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000121">
        <property type="entry name" value="Serine/threonine-protein kinase nrc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000078">
        <property type="entry name" value="Serine/threonine-protein kinase nrc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45637">
        <property type="entry name" value="FLIPPASE KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="255"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL25937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="628" mass="68706" checksum="85E455CB62D5B28E" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PIP4</accession>
    <name>A0A0G4PIP4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit M</fullName>
            <shortName evidence="5">eIF3m</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S017g000029</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit M family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793150">
        <property type="protein sequence ID" value="CRL26046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PIP4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PIP4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03012">
        <property type="entry name" value="eIF3m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027528">
        <property type="entry name" value="eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040750">
        <property type="entry name" value="eIF3m_C_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF2">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18005">
        <property type="entry name" value="eIF3m_C_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="7">
        <location>
            <begin position="211"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="425"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL26046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="458" mass="50070" checksum="22A86E4BAEF063E7" modified="2015-09-16" version="1">MPAPTNTLLIEGSFSELADEFAQYIDALRKEGSLQSEIAPLLEPLRQQEQSEGEADLKQRDEVLKKLVSSATALNSAPEKDFSKNAEITSAYNLLVHLVHQSSDADVFLPRICTYLAKPITTSPQFGPTLAISILTTIFNTLSSNDSSRYHVLLAVVAVIRQSGSGIAFEALKPQLTSQLPTWLSAWELDSDDTRKLHIAIAEASTAAGDEDLAQTHIVQALETIDAADVSKPESRELAVRALATALRRSTVFDFTPLTASDAVQALRSSDSTLFELLEIFTSDTLDAYETFVAANPLASISGGVLAESADALQTKMRLLTLTSLASSTPSRSLPYATIASALRVPASDVEMWVIDTIRAGLVEGRLSQLKSEFLVHRATYRVFGEKQWSEVQGRLMVWRRSLENVLSVIRSERERFAREGIQAAADQEANANRNGNGDRRRIQPAQPQAREVEATAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PIZ4</accession>
    <name>A0A0G4PIZ4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S017g000164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793150">
        <property type="protein sequence ID" value="CRL26181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PIZ4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL26181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="70" mass="7688" checksum="AFF0BDEF6A19DF81" modified="2015-09-16" version="1">MIILNIVHAACEKVAGWEAGRGSRSVARRVPIFAPFQALGVLMDFQCMPCYLSPGFHGGDRWLRPGDWGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PK30</accession>
    <name>A0A0G4PK30_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S018g000206</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PK30"/>
    <dbReference type="STRING" id="1429867.A0A0G4PK30"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF52">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="50"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL26513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="508" mass="55885" checksum="AF30E3D1F36943C6" modified="2015-09-16" version="1">MVFARGDVSGHDDQTIDHQDPSKDVTIVSWDGPRDPGNPYNWSLCEKWLLTALAVFATFMTMINGTIITVAHDPMNEFFNVSDANFPHSYWPVTSWAVGGGCFSLLVLPLMEDFGVRWVFLGTYVTFLCFVVPQAVAQNFYTLVITRFFAGGCVSILANTSGTVIGNVWDTERNRNVPVSLFIVAYLSGSSIGPVIGAAIYQALTWRWIGYIQLMWYGAFFPLYFFLFKECRGIAILGQRAKALRREGKNAYTQHEIDTQGQSILSIVGHSASRPLFLFFTESVVFVSTLWSAFTVGTLYLFTQSVEQVFAELYGWTPAQAGYVQAAVVIGELLGWVITLFSGKLYFDSASRNKEIPGTPIPEARLYLAILGGIFGISGGMFTYAWTSYPDFPWIAPAVGLAMVGAGSVIVVTGISDYVVDAYSKYAGSCMGIIATGENTLAAFLPLATMSMYSHLGLEWASTVLGFIALALSFAPILVLIWGKNIRARSPFMKEAMVEKRRKSIDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKB9</accession>
    <name>A0A0G4PKB9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S019g000252</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKB9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PKB9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="82"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="140"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="153"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL26835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="787" mass="88464" checksum="944A033B0F8CD13F" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PLH6</accession>
    <name>A0A0G4PLH6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S020g000162</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793153">
        <property type="protein sequence ID" value="CRL27003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PLH6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PLH6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AUSG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL27003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="512" mass="58770" checksum="7235AC61BAA39430" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PLZ7</accession>
    <name>A0A0G4PLZ7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S021g000123</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793154">
        <property type="protein sequence ID" value="CRL27208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PLZ7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PLZ7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL27208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="369" mass="39310" checksum="A4D0FD8F4D62EFA2" modified="2015-09-16" version="1">MSSSTPQFLKTTAKTPHSTPGPTNPHTNLLTIDTLISILSKSLLNPFIAWIFVLCLRAQVTPSTDPAWIIAVSYATALTVLSIARIINQRAADGVPRTVDFEHEVVVITGGASGLGLLIAQMYSMRGASVAVLDIKVVPENSRDEVFGEGVLYITCDVADRSALELARERILQELGTPTIVINCAAARINGLSLLDLPADAFEKTIRTNLLAAFHLYQVFLPGIIAAESGGTLVTVSSVLGQLSAAGLSDYAASKAGLSALHRTIEAEVRGNPLIKTLLVEVGQMSTPLFDWVRAPSHFFAPVLEPVEVARDMVAAIDSGRGGVIRLPIYAKLVNWYAVLPATVQRVARYLSGIDAAVTQSQQASGKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PM81</accession>
    <name>A0A0G4PM81_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Kinesin, motor domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PCAMFM013_S022g000124</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793155">
        <property type="protein sequence ID" value="CRL27444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PM81"/>
    <dbReference type="STRING" id="1429867.A0A0G4PM81"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000073">
        <property type="term" value="P:initial mitotic spindle pole body separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01364">
        <property type="entry name" value="KISc_BimC_Eg5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000051">
        <property type="entry name" value="Kinesin-like protein bimC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047149">
        <property type="entry name" value="KIF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047241">
        <property type="entry name" value="KIF11-like_kin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025901">
        <property type="entry name" value="Kinesin-assoc_MT-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970:SF12">
        <property type="entry name" value="KINESIN FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Microtub_bind"/>
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            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms a chaperone-bound H2A.Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A.Z histone replacement in chromatin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Forms a heterotrimer with H2A.Z-H2B, stabilizing the association of the histone dimer. Also, with a lower affinity, forms a heterotrimer with H2A-H2B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CHZ1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793157">
        <property type="protein sequence ID" value="CRL27920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PNG0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PNG0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019098">
        <property type="entry name" value="Histone_chaperone_domain_CHZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09649">
        <property type="entry name" value="CHZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01082">
        <property type="entry name" value="CHZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone chaperone" evidence="8">
        <location>
            <begin position="49"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="84"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL27920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="112" mass="12677" checksum="C8E5D0B97410BFC0" modified="2015-09-16" version="1">MADQATISNSNEQAFAKGKGKADPTQEMSMDEESESESENEIADNDEEDDTQDNLNDPIDQSNIIQGGRRTRGKVIDYSKISTDEMEDDEDDDEEYEGREDNEANDDDQMRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNM4</accession>
    <name>A0A0G4PNM4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histidine phosphatase superfamily, clade-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S025g000032</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793158">
        <property type="protein sequence ID" value="CRL27974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PNM4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PNM4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF142">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195495" evidence="4">
        <location>
            <begin position="22"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="429"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL27974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="482" mass="51013" checksum="E70162508307667F" modified="2015-09-16" version="1">MRYSIQSGLLLAASLSPIVDAERVLGAYIFARHGDRTPKVFGNTQLTDLGYREVFDCGSFYNDRYISSSSSKQIEGISADVVKPKQISASAPSDTVLQNSATGFLQGVYPPVGKVASQTLGNGTSVEAPLNGYQLIQLLPATTSKNAEDSTWLQGSSGCQKATVSSNNYFSSEMYTSLLSSTKEFYQSLSPMLDGAFASSDMSFKNAYTIFDYLNVGKIHNSTSQFPHKSDLTDEVYHQLIALAGSHEFNLAYNSSDKVRAIDGAVLAGEILAGLNETIATKGNTKLNVGFGSYGTIFSLFGLLQMPAASVNFTGIPDYASSMVFELVTNASGTNFPTDKSDLSVRFMFHNGTITGSSEPTAYPLYGQSSELLSWDDFSSKTKAIAVTSDDEWCTMCGNTDGKCTSSASTSSDSGSASTSSTSGSGMSLAVAGVIGAMVTLAVILGLQAIFFLLGGFRIAKRNKASPEIMSAAAAVEAEKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNX8</accession>
    <name>A0A0G4PNX8_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-ribulosamine 3-kinase</fullName>
            <ecNumber evidence="1">2.7.1.172</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S024g000133</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6)-D-ribulosyl-L-lysyl-[protein] + ATP = N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48432"/>
            <dbReference type="Rhea" id="RHEA-COMP:12103"/>
            <dbReference type="Rhea" id="RHEA-COMP:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:90418"/>
            <dbReference type="ChEBI" id="CHEBI:90420"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.172"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:48433"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fructosamine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.172" evidence="1"/>
    <dbReference type="EMBL" id="HG793157">
        <property type="protein sequence ID" value="CRL27878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PNX8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PNX8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102193">
        <property type="term" value="F:protein-ribulosamine 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1200.10:FF:000018">
        <property type="entry name" value="Fructosamine-3-kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016477">
        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149">
        <property type="entry name" value="FRUCTOSAMINE 3 KINASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149:SF8">
        <property type="entry name" value="PROTEIN-RIBULOSAMINE 3-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03881">
        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006221">
        <property type="entry name" value="Ketosamine-3-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL27878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="346" mass="37399" checksum="C0099BCF468110AB" modified="2015-09-16" version="1">MSPVPEPIIQALSLPSESKASLSTSGLGSGFTSTGTIHAQIPGKNGKGERRYFVKTSSNGKAAEEMFQGESESLNAIAASVPGFCPQALAQGPLDELGTEAKTYFLATEFLELGGKMGRSTSVEATLVHRLGKLHTTPAPPDPNTGRRRFGFPVPTFCGDTKQPNRFCDSWAEFYANERLLTILATSEVRNGPDAGLREAVEKTAHKVVPRLLGDGHLGYTSSGEGEEVVPVVVHGDLWSGNADWGRIVGSGGDETPGDVVYDPSACYGHSEFDLGIMHMFGGFGARFFDQYHRIVPKTEPVAEYADRVELYELYHHLNHHAIFGGGYRSGAMSIMQKLTRKYGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPU8</accession>
    <name>A0A0G4PPU8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S027g000084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793160">
        <property type="protein sequence ID" value="CRL28395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PPU8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PPU8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
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    </organism>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Lacoste S."/>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="531"/>
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        <location>
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            <end position="1056"/>
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        <location>
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            <end position="1362"/>
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        <location>
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        <location>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS51194"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL28469.1"/>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="1558" mass="170337" checksum="BC01680A94D0A20E" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQN1</accession>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Silar P."/>
                <person name="Lacoste S."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">FM 013</strain>
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        </subcellularLocation>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00008300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL28710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="36196" checksum="36844679D102246D" modified="2015-09-16" version="1">MASEITPNTFLTTTGSPSDQKTTIFFISGNPGLIGYYHPFLSLLAKHLDESKEELLTSLPSFQIYGCSLSGFEIDEPQSSPSPNNAIDLDLEGQICFVQGKLATLMGDEANGNGKGARQRVILIGHSVGAYIAMEILRRHRETSPESTFDIVGGAMLFPTVKDIAASPSGQKLTTLLSIIPRLAVVVSFFARLLTFLLPTSLLRSVVRLVMGDPPVHALDATCAFLKSRGGVRQALHMAADEMRTITSDKWSDDVWGAASAREPITKLFFYFGRNDHWVADQTRDEIVAVRGQKGGQAGPTMVVCEEGLPHAFCLKHSDVMARKVAGMIGQIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PR60</accession>
    <name>A0A0G4PR60_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S031g000067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793164">
        <property type="protein sequence ID" value="CRL28899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PR60"/>
    <dbReference type="STRING" id="1429867.A0A0G4PR60"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL28899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="118" mass="12998" checksum="E854EB141BCD6E02" modified="2015-09-16" version="1">MRTSSELCIVPIGEGAPDNKIVNLINGVCTPLGEGNRQTDHQVFLLQKPTEVFEAAGFADISLRRVEAYCNFPEKVSSNGVQKLRNSWAAFVLEKHLKSPPTSVMKPSSFLLHRTSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRP5</accession>
    <name>A0A0G4PRP5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S033g000007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793166">
        <property type="protein sequence ID" value="CRL29087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PRP5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024368">
        <property type="entry name" value="Ecl1/2/3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12855">
        <property type="entry name" value="Ecl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL29087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="330" mass="35117" checksum="7BD236930EDC0F65" modified="2015-09-16" version="1">MTQTAPFQRRSPSSPHASKSKSTRPALHRRGTSSANVSISKLGSGQKGASKPPTSTDDIEFDMASFLNFCAMCENQITVPNNTLLYCSESCRRKDSCKPLSASLPSMSSMSSNTTPPTSPPLSPRTIVAPLTPTRVPSHSIPTMRIPSHVHDAKSDLDPTEWKPVLTRNASSLASSDAWNYLSQFHRGNGEPMLSRPTVQRSSSSLPALAGGVAHSHSHVPSLTNTPSTVASSFSSTASDYLGSMYESRPLPPRHNPYFSGTSVTKGVELVVPHIASAHEDLGPIGVSDSGSIFPASSAVWEDSSYEKRSAPISMARGIGGRPVETCVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PSW9</accession>
    <name>A0A0G4PSW9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fatty acid desaturase, type 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S034g000039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793167">
        <property type="protein sequence ID" value="CRL29241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PSW9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PSW9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03507">
        <property type="entry name" value="Delta12-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="2">
        <location>
            <begin position="76"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL29241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="398" mass="45276" checksum="A74E916B7FD32234" modified="2015-09-16" version="1">MAVTQRQPVKQAEQQTQPTDVPSLQALKDAIPKECFDSSLTTSLLYLARDILYCAALIYAALHIHLLPSLPMRVAAWAVYGFFQGCVGTGLWILAHECGHGAFSKHQGINDFIGWATHSFLMVPYFSWKITHARHHRYTGHMEKDTVFVPWTEDDLASKRNVSIEQLKHLAEETPIVSFIQLIGHQLLGWQMYLILNVTAGTKSGPEGGEKVKFESHYNPSSSIFTAAQWKLIAYSDIGLLIMGSIVWYTGTIIGAWNVFFLYVVPYLWVHHWLIAITYLQHTHPEVAHYTAEAWTYTKGALATIDRTTGFIGRHFFHEIIDYHVVHHLFSRIPFYNAEKATKAIQPMLGENYHEEKEESFLYSLMVTFRKCIYVSESKGRASGQPGVLHFVLSDESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PTQ7</accession>
    <name>A0A0G4PTQ7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Serine/threonine-protein kinase DCLK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S040g000029</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793173">
        <property type="protein sequence ID" value="CRL29803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PTQ7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PTQ7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="40"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL29803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="397" mass="45716" checksum="B717FE48154B0A00" modified="2015-09-16" version="1">MDLSLYYQSNLLYTQESLSKYQPGGYHPVNLGDTFENDRYKIYHKLGWGGFSTVWLAKDRDRNQWVSLKIMTANSSISRELQILKTLEKQSQRGLSSNYIVQLLDTFTHKGPNGAHQCLVFELLGPSVDKVLADYHEAHDKLDPETVLRISTQLLKAIKFIHSANMCHGDISGRNIAFSCTHLSNQTEEQLFDVLGFPETEPLKRVDGMPLGNELPAQLIKAAEWTEWIDEDDEDIRILDFGESFYQGQEPQKLAQPASLRVPETIFTDSFDYRVDLWRIGCMIYSFLFTTWPFWYLGEDEVLIYQMIGFVERLPAKWQSKWESMMMSSSHNLELEEDYGTSKLERKFADSVPDPTLKPLLHVIQGLMRFLPSDRLTTEEALDLLGNVEISGHIKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUB4</accession>
    <name>A0A0G4PUB4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S039g000073</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793172">
        <property type="protein sequence ID" value="CRL29764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PUB4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06178">
        <property type="entry name" value="MFS_unc93-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF59">
        <property type="entry name" value="UNC93-LIKE PROTEIN C922.05C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL29764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="501" mass="55332" checksum="6D2D77ED56874536" modified="2015-09-16" version="1">MDAFKRNERKTPPAYSTEPDPAPRPPGWMYKSNKIGKFSTSWYASPRIQLGMVAFVCFLCPGMFNALSGMGGGGKSDPNLADKMNIALNSTFAVVGFFAGTVVNRIGVRLSLSFGGVGYCIYSISLLVSEHAYVPGFNIFAGAFLGVCAGLLWAAQGTIMMSYPIEQQKGRYFAWFWGIFNVGACIGSLIPLGQNIHVTENKTVGDGTYIAFIVLMFAGACLALCLCDADKVVRPDGSRVILMKNPSWKSEIVGLWDTVRSEPWIVLLFPMFWSSNWFYTYQQNAINGAYFNTRTKALNGFLYWFAQIVAAVIMGPLLDTERVRRSVRAKVALVTLFVLTVAIWGGGYAWQVRYTREDVNPATTDFKGWDWTTKGYVGPMFLYFFYGMYDAAWQGLVYWIMGALGNSGRKLANLAGFYKGLQSAGAAVMWSLDERKIPFMNEYASNFGLLCGSILIAVPVVFFKIKDSVPAEEELEGTGETLEDVLPPGAIESRHVGDDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUD4</accession>
    <name>A0A0G4PUD4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S043g000003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793176">
        <property type="protein sequence ID" value="CRL30008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PUD4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL30008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="89" mass="9458" checksum="5509375BC5F526C6" modified="2015-09-16" version="1">MAASALPLLSVNPEASSVNVNTAKHTDETMTPVEIAKRVNESEPSIDIAKRINEVEASVDIAKCASRTRKRLCSAASITASAVSYITVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-11-27" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUZ2</accession>
    <name>A0A0G4PUZ2_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Succinate dehydrogenase assembly factor 3</fullName>
            <shortName evidence="8">SDH assembly factor 3</shortName>
            <shortName evidence="8">SDHAF3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S045g000027</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 8">Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the complex I LYR family. SDHAF3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793178">
        <property type="protein sequence ID" value="CRL30161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PUZ2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PUZ2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006105">
        <property type="term" value="P:succinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20270">
        <property type="entry name" value="Complex1_LYR_SDHAF3_LYRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008381">
        <property type="entry name" value="SDHAF3/Sdh7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137">
        <property type="entry name" value="DC11 ACN9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137:SF6">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL30161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="128" mass="14624" checksum="D9A9C9B4617A566C" modified="2015-09-16" version="1">MRIAQRLLMATPASIGSKSSLSEALALLPPLQLYRRILRVHRKLEPEMRVLGDSYVKNEFRAHRSVENPLHIIGFLTEWQLYAQKLEGDQWAGDKLDQAKLDKMSDQQLGQLLELMQALRNEGEGEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUZ8</accession>
    <name>A0A0G4PUZ8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S042g000011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PUZ8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL29952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="51" mass="5315" checksum="90C4E2EF03F69F93" modified="2015-09-16" version="1">MASRSFHGREQNSGQPGVASTVSSATKASLNPNMCSWRVNSESAGVARAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PWL3</accession>
    <name>A0A0G4PWL3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S053g000035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793186">
        <property type="protein sequence ID" value="CRL30527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PWL3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL30527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="77" mass="8589" checksum="48BA29840E6D8C28" modified="2015-09-16" version="1">MYLPSGRGANKMVSILVRRGCVDRALMVDLEMVRFWFQGLEPRTRTSGSAVLIYKDCTAPRLYAALSRFEPHGAAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PXB2</accession>
    <name>A0A0G4PXB2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="15">AMP-dependent synthetase/ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S068g000006</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793201">
        <property type="protein sequence ID" value="CRL31020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000284">
        <property type="entry name" value="Siderophore iron transporter mirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054710">
        <property type="entry name" value="Tri101-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22664">
        <property type="entry name" value="TRI-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="15" id="KW-0436">Ligase</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="194"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="14">
        <location>
            <begin position="836"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="903"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CRL31020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1449" mass="161622" checksum="DD1A5332A5C1541F" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PXJ5</accession>
    <name>A0A0G4PXJ5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="1">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S061g000023</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peroxiredoxin family. BCP/PrxQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="1"/>
    <dbReference type="EMBL" id="HG793194">
        <property type="protein sequence ID" value="CRL30849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PXJ5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PXJ5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02970">
        <property type="entry name" value="PRX_like2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
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        <source>
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    </evidence>
    <sequence length="214" mass="24222" checksum="655994218D151F11" modified="2015-09-16" version="1">MALNKELSSTYNQFLETAPKEVSSIITEAVREFNNIYDPARAVQPGDAFPQFQLSDATGNEVSLNDLLVKGPILISFYRGEWCPFCNFELRALQSHMDEFHQKGVTLVAVSPELPDQSLSTSEKLSLKFPVLSDVGNQLAKQLGLLFPQPESMRTVFDKFGVDWNQRYGNDNLELPVPATFLVDKKGIVRNSFVNPEYRHRLEPETAIEWIGRL</sequence>
</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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                <person name="Abraham A.L."/>
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                <person name="Debuchy R."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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            <begin position="26"/>
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        </location>
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    </evidence>
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            <dbReference type="EMBL" id="CRL31277.1"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NSL9</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NSL9"/>
    <dbReference type="STRING" id="1429867.A0A0G4NSL9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000191">
        <property type="entry name" value="mRNA splicing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032847">
        <property type="entry name" value="PRPF17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="285"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="329"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="415"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="5">
        <location>
            <begin position="495"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="557"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL17081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="583" mass="64597" checksum="077EB471766F21CC" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NSX0</accession>
    <name>A0A0G4NSX0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cellulase</fullName>
            <ecNumber evidence="4">3.2.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Carboxymethylcellulase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Cellulase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PCAMFM013_S001g000009</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Has endoglucanase activity on substrates containing beta-1,4 glycosidic bonds, like in carboxymethylcellulose (CMC), hydroxyethylcellulose (HEC) and beta-glucan. Involved in the degradation of complex natural cellulosic substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 21">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="4"/>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NSX0"/>
    <dbReference type="SMR" id="A0A0G4NSX0"/>
    <dbReference type="STRING" id="1429867.A0A0G4NSX0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000078">
        <property type="entry name" value="Endo-beta-1,4-glucanase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142:SF6">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 16 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005194772" description="cellulase" evidence="17">
        <location>
            <begin position="19"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="18">
        <location>
            <begin position="38"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CRL17049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="333" mass="36316" checksum="ACAB4B26B5E38306" modified="2015-09-16" version="1">MRLDQIALLAAVAGSAAAAPANNHAKRASPFKWFGASESGAEFGENNLPGVYGTDYIFPDASAIQTLKEKGMNIFRVAFRMERLAPNSLTGELDAGYLTNLTATVKAITDAGSHAVLDPHNYGRYNGEIISTTSDFQTFWKNVAGEFVSNELVIFDTNNEYHDMDQDLVLKLNQAAIDGIRAAGAKSQYIFIEGNSYTGAWTWTDVNDNLKALTDPQDKIVYEMHQYLDSDGSGTSETCVSTTIGKERVTDATQWLKDNNKVGIIGEFAGGVNDNCKTAITGMLDYLGDNSDVWLGALWWGAGPWWGDYIFSMEPPSGTAYTGMLSTLEPYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NT90</accession>
    <name>A0A0G4NT90_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Ornithine aminotransferase</fullName>
            <ecNumber evidence="4 9">2.6.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S001g000257</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 2-oxocarboxylate + L-ornithine = L-glutamate 5-semialdehyde + an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:13877"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="EC" id="2.6.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.13" evidence="4 9"/>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NT90"/>
    <dbReference type="STRING" id="1429867.A0A0G4NT90"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004587">
        <property type="term" value="F:ornithine aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019544">
        <property type="term" value="P:L-arginine catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010121">
        <property type="term" value="P:L-arginine catabolic process to proline via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000011">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000152">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010164">
        <property type="entry name" value="Orn_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01885">
        <property type="entry name" value="Orn_aminotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF18">
        <property type="entry name" value="ORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL17297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="451" mass="49023" checksum="572671EEFB77F9D2" modified="2015-09-16" version="1">MATNGPFSHYHAASSAEAIESEKEYAAHNYHPLPVVFARAQGTSVWDPEGRHYLDFLSAYSAVNQGHCHPKLIAALVDQASRVTLSSRAFYNDVFPRFAKFVTSYFGFDMVMPMNTGAEAVETGIKIARKWGYKVKGIPENKAVILSAENNFHGRTFAAISLSSDPESRENYGPYLPGIGCTIPGTEKPIAYNDKVALREAFEAAGPNLAAFLVEPIQGEAGIVVPDPDYLQEARALCDKHNVLLICDEIQTGIARTGKLLCHEWSGIKPDLVLLGKAISGGMYPVSCVLGSKDVMLTIEAGTHGSTYGGNPLGCAVAIRALEVVREENMVERAEQLGHLFRDGLVAIKSPVIQTVRGKGLLNAIVIDESKTNGHTAWDLCMLMKEKGLLAKPTHQNIIRLAPPLVITEEEIQKALDIIKEAVTDLPNLKGASEDQIIPPAEKKIKIDLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NTG8</accession>
    <name>A0A0G4NTG8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoglycerate/bisphosphoglycerate mutase, active site</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S001g000296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NTG8"/>
    <dbReference type="STRING" id="1429867.A0A0G4NTG8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005194973" evidence="1">
        <location>
            <begin position="20"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL17336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="185" mass="20343" checksum="0B4DB5EB3C7D7EF9" modified="2015-09-16" version="1">MLLQSALSALCLCLGIASAKSHPTVYMIRHGEKPQNPNDHGLTPDGVKRAQCLRRVFGQGSEYGIGHIMAPRVEWDGAHGRAFETVLPLANDLGLTVDTHCKRNKVKCVAKAIRSYDGPGNILIAWRHSKMGGIEEALGALEPIEYPDERFDLIWTDPWPYGNITSIKSEECPGLDVRTGLVDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NTJ6</accession>
    <name>A0A0G4NTJ6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="6">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S001g000328</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 9">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Cd(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48775"/>
        </cofactor>
        <text evidence="5">Binds 1 divalent cation per subunit. The enzyme is active with manganese, cobalt or cadmium ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-II DAHP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="6"/>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NTJ6"/>
    <dbReference type="STRING" id="1429867.A0A0G4NTJ6"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002480">
        <property type="entry name" value="DAHP_synth_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337:SF0">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01474">
        <property type="entry name" value="DAHP_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0104">Cadmium</keyword>
    <keyword evidence="5" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL17368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="461" mass="50328" checksum="7AAE03FA4A55A03E" modified="2015-09-16" version="1">MAEWSPSSWTQKPIKQDVIYEDLQGLKVSLQKLQKLPPLVTTQEIINLKKNLRNVALGKAFVLQGGDCAELFDYCSQEMIEAKVKLLLQMSLVLIWGANKPVIRIARIAGQFAKPRSSPTEVINGVEMPSFRGDNINGFAADPASRQPDPSRLVSAYFHSAATLNYLRASLSSGLADLHSPLDWGLGHVITPSIKEQYTKTVGAVKDALRFMHTVGIDKDRGFETADIFTSHEGLSLEYEQSLTRLLRHPANAGSSTSSTSPETGYYATSSHFLWIGDRTRQLGGAHVEFFRGIANPVGIKIGPSMAPDELVQLLDVVNPDREVGKVTLISRYGASKIANFLPGHIAAVQASGHIPVWQCDPMHGNTQSTPSGVKTRHFTDILSELKQALEIHRAAGSFLGGMHLELTGEAVTECVGGAAGLTEDGLGERYTTFCDPRLNEKQALELAFLVAGFYREESEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-11-27" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NUQ7</accession>
    <name>A0A0G4NUQ7_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S001g000771</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Vacuole membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATG22 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NUQ7"/>
    <dbReference type="STRING" id="1429867.A0A0G4NUQ7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032974">
        <property type="term" value="P:amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17483">
        <property type="entry name" value="MFS_Atg22_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044738">
        <property type="entry name" value="Atg22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF4">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 11" id="KW-0072">Autophagy</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="423"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL17811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="565" mass="64032" checksum="2391818B477349C7" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NUU9</accession>
    <name>A0A0G4NUU9_PENC3</name>
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        <submittedName>
            <fullName evidence="5">Hydantoinase/oxoprolinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S001g000774</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4NUU9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="4">
        <location>
            <begin position="11"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="2">
        <location>
            <begin position="244"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="3">
        <location>
            <begin position="740"/>
            <end position="1260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL17814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1297" mass="140338" checksum="462E071A2076D285" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NVC2</accession>
    <name>A0A0G4NVC2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tyrosine-protein kinase, catalytic domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S001g001006</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
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    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
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    <dbReference type="STRING" id="1429867.A0A0G4NVC2"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000640">
        <property type="entry name" value="Serine/threonine-protein kinase PRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="309"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="117"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL18046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="644" mass="70194" checksum="11ACC47519063472" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWK0</accession>
    <name>A0A0G4NWK0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S002g000348</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWK0"/>
    <dbReference type="STRING" id="1429867.A0A0G4NWK0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="DUF3405"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205:SF4">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11885">
        <property type="entry name" value="DUF3405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL18478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="647" mass="74381" checksum="96E6F8C273CE520A" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWR3</accession>
    <name>A0A0G4NWR3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase, ATP binding site</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S002g000437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWR3"/>
    <dbReference type="STRING" id="1429867.A0A0G4NWR3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF109">
        <property type="entry name" value="RIBOSOMAL LYSINE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL18567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="326" mass="36048" checksum="DF64C9847A7B6940" modified="2015-09-16" version="1">MEYQIMDQIIHLLANGEEVIDMDEESFLLFAQDIQSNNLGMLNPRAPSVEISIHGNEYTIHQSPSLLSSHRAGGTTGAVLWKITPLFAEWITNPSNPLWTTSLLSQTSTVAELGTGISALVALVLAPSVRHYIATDQEYVRKLFRTNLDANASVGVSSSNSKAKGKSKGSKSSKSKSNSTAKPADNVSFTTLDWETDQAASLKDCVDSDDAHAQDEEEEEEDKGFDLLLSCDCIYNEALVAPFVRTCAEICRLRPAYVAGSEEPRPHRKPTVCIIAQQQRSPDVFETWLRETMREFRVWRLSDDVLGEGLKSGSGYLVHLLLVRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWS4</accession>
    <name>A0A0G4NWS4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit G</fullName>
            <shortName evidence="5">eIF3g</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 RNA-binding subunit</fullName>
            <shortName evidence="5">eIF-3 RNA-binding subunit</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Translation initiation factor eIF3 p33 subunit homolog</fullName>
            <shortName evidence="5">eIF3 p33 homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TIF35</name>
        <name evidence="9" type="ORF">PCAMFM013_S002g000447</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit G family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWS4"/>
    <dbReference type="STRING" id="1429867.A0A0G4NWS4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12933">
        <property type="entry name" value="eIF3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12408">
        <property type="entry name" value="RRM_eIF3G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000328">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03006">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017334">
        <property type="entry name" value="eIF3_g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024675">
        <property type="entry name" value="eIF3g_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034240">
        <property type="entry name" value="eIF3G_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12353">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037949">
        <property type="entry name" value="Transl_init_eIF-3_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="207"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="159"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL18577.1"/>
        </source>
    </evidence>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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        </source>
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    </evidence>
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    </evidence>
    <sequence length="947" mass="107830" checksum="E029EB6372705986" modified="2015-09-16" version="1"> </sequence>
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    <accession>A0A0G4NXN8</accession>
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    </dbReference>
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        <property type="entry name" value="PRE-RRNA PROCESSING PROTEIN"/>
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            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NY57"/>
    <dbReference type="STRING" id="1429867.A0A0G4NY57"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039903">
        <property type="entry name" value="Zswim2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21540:SF0">
        <property type="entry name" value="PHD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21540">
        <property type="entry name" value="RING FINGER AND SWIM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="4">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="122"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL18909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="206" mass="23279" checksum="DF7C94E4BAF089D1" modified="2015-09-16" version="1">MAYFGWLISVAFRMYMIRHGIGGTKDVPKISFEVVGSTGNIYRTIIGKVPTCDCPDVKFRKVQCKHMCFVVSAMDVPSELMYQKSFLPSELREMLDTLSLKRKLDTTTPTSAGERKPLDGACPICFKDFKPNQKTTWCQDCGSNFHQGCFQKWGAAMQASDDVVRCLYCKVPWKGDEHETPRPTAKPVETDGPRRSKMKYPNVGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYH9</accession>
    <name>A0A0G4NYH9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">E3 ubiquitin ligase complex SCF subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S002g000995</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Controls sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 6">Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the SKP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL19125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NYH9"/>
    <dbReference type="STRING" id="1429867.A0A0G4NYH9"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18322">
        <property type="entry name" value="BTB_POZ_SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000026">
        <property type="entry name" value="E3 ubiquitin ligase complex SCF subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028729">
        <property type="entry name" value="E3_ubiquit_lig_SCF_Skp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="8">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component dimerisation" evidence="7">
        <location>
            <begin position="109"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR028729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL19125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="158" mass="18040" checksum="AED8EB984D57F49D" modified="2015-09-16" version="1">MSAITLTSSDGVDISVERTTAERSVLIKNMLEDLGDSGEAIPIPNVNEAVLKKVIEWCEHHKNDPPSASDDDDNRRKTTDIDEWDQKFMQVDQEMLFEIILAANYLDIKALLDVGCKTVANMIKGKSPEEIRKTFNIQNDFTPEEEDQIRRENEWAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0P2</accession>
    <name>A0A0G4P0P2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptidase S54, rhomboid</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S003g000673</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P0P2"/>
    <dbReference type="STRING" id="1429867.A0A0G4P0P2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000012">
        <property type="entry name" value="Rhomboid family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050925">
        <property type="entry name" value="Rhomboid_protease_S54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731:SF14">
        <property type="entry name" value="PRESENILIN-ASSOCIATED RHOMBOID-LIKE PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731">
        <property type="entry name" value="RHOMBOID PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="437"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="505"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="9">
        <location>
            <begin position="401"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="53"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL19881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="575" mass="64871" checksum="8A925F50A93E8A2C" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0T2</accession>
    <name>A0A0G4P0T2_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein bL32m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S003g000722</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P0T2"/>
    <dbReference type="STRING" id="1429867.A0A0G4P0T2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00340">
        <property type="entry name" value="Ribosomal_bL32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051991">
        <property type="entry name" value="Mitoribosomal_protein_bL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_bL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21026">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21026:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL32M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL19930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="125" mass="13950" checksum="4C59E2FF75E7E13A" modified="2015-09-16" version="1">MALRLLPFAPATMSRSLLSESLQFPRLARFLPITPIATSGFLQPVSISLNIPSLLSDLWDSVLRAVPKKKTSHMKKRHRQMAGKALKDVKSLNKCPGCGQVKRAHLLCPNCVKDIKESWRTLDMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P106</accession>
    <name>A0A0G4P106_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beta-lactamase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S003g000755</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P106"/>
    <dbReference type="STRING" id="1429867.A0A0G4P106"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07730">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF5">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="5">
        <location>
            <begin position="57"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL19963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="373" mass="41445" checksum="44DDCE5988CC934D" modified="2015-09-16" version="1">MIESSHLVPPKTPPALHIPPSTATVTVRVIDSTTSLLLDPPLFWQPEIKGLHGLTVSDFCFLVSNGNRHVLFDLGMRVDWENYAPKVVRLIQQTTRVHVEKNVAEILDTQQEWPEDGPVVRSKDIEAIIWSHHHFDHIGDPSTFPAATDLVVGPGVRSVCWPGYPTNPDSLVLDKDIQGRHVREIGFTSSSAHHCRIGRFDAFDFFGDGSFYLLDAPGHSVGHMIGMARVTAADGPDGQDSYVLMGADACHHPGVLRPTEYLPIPTLVEPSPIQQWSACPGDWLQHLHPHGSATEPFLSVSPVLFPEFDAAMDTVKKIQELDAVDNILVILAHDETLKKHIKLFPHRINDWMSTEVAAQTRWLFCGDFEASIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P216</accession>
    <name>A0A0G4P216_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Repressor of RNA polymerase III transcription MAF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S004g000290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mediator of diverse signals that repress RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P216"/>
    <dbReference type="STRING" id="1429867.A0A0G4P216"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000994">
        <property type="term" value="F:RNA polymerase III core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016480">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1000.50:FF:000004">
        <property type="entry name" value="Repressor of RNA polymerase III transcription MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.50">
        <property type="entry name" value="Repressor of RNA polymerase III transcription Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015257">
        <property type="entry name" value="Maf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038564">
        <property type="entry name" value="Maf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504:SF0">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09174">
        <property type="entry name" value="Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037240">
        <property type="entry name" value="RNA_polIII_Trep_MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL20350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="331" mass="37443" checksum="8FF406473A1AAC33" modified="2015-09-16" version="1">MKFLPLPEFEDVTSSLNFDTADCHIVGGCDIYTTKAARSDRKLYNHIEQSLEAQYESVLRFSASLSPPNAHDAAETLNLSRSSPFGPLSDHSSRRTFAYLIATLNASHPDYDFSHVLRPTDFRRERNLKRVMNTVDSTLLNLRPRENTNLSPASPATLSGSYTAGSSSAWGPRVWKTIDEHMSLKECSIYSYSPEEDPSDADDGAIWSLHFFFFNPIRKRVCYIFLRAIPILSHTPDEMATTPTGKRTYDDGYLTPDLSSSKRAKFWFGERARSTLVASDSDDEMERPSKTIRNDSDDYDTYVISDDEENLPINRRGVRAMSEEIADSMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P238</accession>
    <name>A0A0G4P238_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S004g000322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL20382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="113" mass="13137" checksum="8E400E03701F17C0" modified="2015-09-16" version="1">MQDAIKPLGELLDVCKPVVFYLTSFDICFRQLKYLFCLLVLVATATVDETAQRKKLVDCINKVLVKENADYGHRDDKLKKTTETVDRVVMKEPVESYIIEEQKQIFSEIEYMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P256</accession>
    <name>A0A0G4P256_PENC3</name>
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        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S004g000351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR38421:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38421">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL20411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="362" mass="41517" checksum="24CC6780E6FF6A0B" modified="2015-09-16" version="1">MSSFEPNAVIRGFQLTVVGTVRALANPELFKYDHFRQAALAIAIGIVIQLIIQIPILSVRFSIYILSWVINMEQAVWDDKLLNGLEFMSKSVLQVPFLLMTLMRYVTPTLDEIFMQSIQWVDMTYIQKHKTEDPHHLRSLYYPNLVQYSAKGGSSVSRPIPQALKSFFNRYAKKIGMMLGIYLLSMVVIIGRFVMPAASFYTFRSHVGSTPAAVIFGVGLILPKHYIVTFLHTYFASRSLMRELLEPYFWRIKFTPEQKRRWFRDREGVLFGFAFAFTVLLRIPYIGVLMYGVAEASTAYLVTKITDPPPPPAESTNFAESQVTWKNKHDFLRLSLDNLDKLNVDTDEHDQKESGSPGKKFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P262</accession>
    <name>A0A0G4P262_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inheritance of peroxisomes protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S004g000350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for peroxisome inheritance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P262"/>
    <dbReference type="STRING" id="1429867.A0A0G4P262"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005780">
        <property type="term" value="C:extrinsic component of intraperoxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045033">
        <property type="term" value="P:peroxisome inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024758">
        <property type="entry name" value="Inp1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12634">
        <property type="entry name" value="Inp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="191"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="462"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="520"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="612"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="679"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="562"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="612"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="679"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL20410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="730" mass="79680" checksum="FF842A4DBA527D6C" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2A1</accession>
    <name>A0A0G4P2A1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">pectin lyase</fullName>
            <ecNumber evidence="12">4.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCAMFM013_S004g000380</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Pectinolytic enzymes consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan methyl ester to give oligosaccharides with 4-deoxy-6-O-methyl-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.10" evidence="12"/>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P2A1"/>
    <dbReference type="STRING" id="1429867.A0A0G4P2A1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047490">
        <property type="term" value="F:pectin lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000003">
        <property type="entry name" value="Pectin lyase F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PECTATE LYASE 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683:SF16">
        <property type="entry name" value="PECTIN LYASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00544">
        <property type="entry name" value="Pectate_lyase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00656">
        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 13 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005194970" description="pectin lyase" evidence="14">
        <location>
            <begin position="20"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Pectate lyase" evidence="15">
        <location>
            <begin position="94"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
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</entry>
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                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate</text>
            <dbReference type="Rhea" id="RHEA:24564"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35973"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.8.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 3-oxoacid CoA-transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.5" evidence="3"/>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P3X9"/>
    <dbReference type="STRING" id="1429867.A0A0G4P3X9"/>
    <dbReference type="UniPathway" id="UPA00929">
        <property type="reaction ID" value="UER00894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008260">
        <property type="term" value="F:succinyl-CoA:3-oxo-acid CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046952">
        <property type="term" value="P:ketone body catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.10:FF:000001">
        <property type="entry name" value="Succinyl-coa:3-ketoacid-coenzyme a transferase subunit b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012792">
        <property type="entry name" value="3-oxoacid_CoA-transf_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014388">
        <property type="entry name" value="3-oxoacid_CoA-transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004164">
        <property type="entry name" value="CoA_transf_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02429">
        <property type="entry name" value="pcaI_scoA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707:SF23">
        <property type="entry name" value="SUCCINYL-COA:3-KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000858">
        <property type="entry name" value="SCOT-t"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01274">
        <property type="entry name" value="COA_TRANSF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="5-glutamyl coenzyme A thioester intermediate" evidence="4">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000858-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL21046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="518" mass="55376" checksum="15CDC2E194B84312" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P491</accession>
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        <submittedName>
            <fullName evidence="3">Taurine catabolism dioxygenase TauD/TfdA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S005g000283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P491"/>
    <dbReference type="STRING" id="1429867.A0A0G4P491"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007817">
        <property type="entry name" value="Isocyanide_synthase_DIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37285">
        <property type="entry name" value="SPORE WALL MATURATION PROTEIN DIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37285:SF5">
        <property type="entry name" value="SPORE WALL MATURATION PROTEIN DIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05141">
        <property type="entry name" value="DIT1_PvcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="2">
        <location>
            <begin position="343"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL21119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="602" mass="67241" checksum="D752708B0B3BFA6F" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P4B3</accession>
    <name>A0A0G4P4B3_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mediator of RNA polymerase II transcription subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S005g000303</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Mediator complex subunit 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P4B3"/>
    <dbReference type="STRING" id="1429867.A0A0G4P4B3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019680">
        <property type="entry name" value="Mediator_Med1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041:SF4">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10744">
        <property type="entry name" value="Med1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0010">Activator</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med1" evidence="9">
        <location>
            <begin position="133"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="557"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="611"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="560"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="611"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="626"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL21139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="762" mass="83596" checksum="AAACFD3576F984E5" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P4G3</accession>
    <name>A0A0G4P4G3_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="4 14">1.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCAMFM013_S005g000380</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
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            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
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        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 14">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
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    </dbReference>
    <dbReference type="GO" id="GO:0005829">
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
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        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979:SF4">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5 14" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0520">NAD</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="6"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CRL21216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="366" mass="39451" checksum="6B58CAC9B876E7FA" modified="2015-09-16" version="1">MAKNFNILVLPGDGIGPEVMAEAVKVLKVFETPQRKFELRQELIGGCSIDAHGKSVTEEVKQAALDSDAVLFAAVGGPKWDNKRRGLDGPEGGLLQLRKAMDIYANLRPCSSTSPSASIAKEFSPFKQDIIEGVDFVVVRENCGGAYFGRKVEEETYAMDEWGYSEAEIQRVTRLSAEVALRHNPPWPLISLDKANVLASSRLWRRVVDKTMAAEYPQVKLVHQLADSASLILATNPRSLNGVILADNTFGDMISDQAGSIVGTLGVLPSASLNGLPGDKTLKTRPYGLYEPTHGSAPTIAGKNIANPVAMILCVALMFRYSLGMEDEAQRLEDAVRKVLDSGLRTPDLGGKAGTREVGDAIVSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P4H8</accession>
    <name>A0A0G4P4H8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S005g000394</name>
    </gene>
    <organism evidence="2 3">
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            <taxon>Eurotiomycetes</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="573"/>
            <end position="620"/>
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            <begin position="1"/>
            <end position="13"/>
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            <end position="252"/>
        </location>
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        </location>
    </feature>
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            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL21230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="691" mass="77185" checksum="5721000801B56EFF" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P4K6</accession>
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        <recommendedName>
            <fullName evidence="2">Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047092">
        <property type="entry name" value="AFUB_07903/YDR124W-like_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021264">
        <property type="entry name" value="AFUB_079030/YDR124W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102:SF1">
        <property type="entry name" value="YDR124W-LIKE HELICAL BUNDLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11001">
        <property type="entry name" value="AFUB_07903_YDR124W_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="138"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
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        <location>
            <begin position="336"/>
            <end position="375"/>
        </location>
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        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
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            <end position="306"/>
        </location>
    </feature>
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        <location>
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            <end position="351"/>
        </location>
    </feature>
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        <location>
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            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL21213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="455" mass="51057" checksum="CF6FA2987431D892" modified="2015-09-16" version="1">MIYIDNDGNLCQRASDSIAESRQTILSPRVTSEFLRAVAMSREAAHAPRQVSPQVPVSSGELPFNNHSSVLSQGVAYSEMGGSQHRMQAPFQSEPSFQPTMWPSSESWPLQHSSQPKKDFGGRSLNLALHQRASISVKERGLLRLYYEKIFQNLQQTNCRIIAKAYIKLVEPRKQVNYPYNGRKIVEGRTQQLDPEATKPPWWPRGVSHREPDHLPKVERIRLLVYMLCEMRETHGITTARLKQCDQPIRRQILPVERLQILDEAYRVREEEERFIDGISDGKPVSISRTNLPQMTEDTSSGQSSPIELVPSQKIIESECSDGISGLDITQATSGDLSRASSYNPSNPYSPAMHLAPTPQYQSVGPSTNMSTSPLELRPKHESLSPGAHLIDQTRSVSTEHYPYPGVSGIPPTQMQFYGNPNLSQNAGVPITHASAENLSTETMMPYGHPYYFNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P4S4</accession>
    <name>A0A0G4P4S4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S005g000462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
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    </evidence>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
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            </authorList>
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        </source>
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        <source>
            <dbReference type="EMBL" id="CRL21342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="104" mass="11448" checksum="BF63EE8126E0B1F1" modified="2015-09-16" version="1">MATQLVQLPEVERLSASVVRILGGNPGKHIHRHKHILNWSRPPANLNRHRRRQTLMGSKPSICALGRKSNSTPSSPDTLARRPCQRAARSTQTLSSGSDLQTPA</sequence>
</entry>
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    <accession>A0A0G4P558</accession>
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            </authorList>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        </location>
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            <dbReference type="Pfam" id="PF24800"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Debuchy R."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
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    <comment type="similarity">
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    </dbReference>
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        <property type="term" value="F:(R,R)-butanediol dehydrogenase activity"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ADH_Zn_CS"/>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
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    </dbReference>
    <dbReference type="Pfam" id="PF08240">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="8"/>
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        </location>
    </feature>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="345" mass="36668" checksum="2F674FB59B831FAE" modified="2015-09-16" version="1">MRAVRFHGRRDIRIDEVEEPIRPAFVGICGSDIHEYLAGPTIVPVTPHPLTEEKLPTTLGHEFSGTVEEVGPGVTGFKVGDRVVVKPNLFDATCSNCSMGRFNCCEKVGFIGFSSQAGGLSDHIVVDSRHAISLPDSIPLDVGALVEPLAVAWHAVSGSPLQTNDTVLVVGAGPIGLAIIQVLKAKGVSPIIAVEVSERRREFALALGATQALNPVDVDAVTQIRALTGNVGADVAFECSGAQAGLDTAISGLRVRGTTVVVSLWEHKPTIDAFAVVFQEKRVAGAALYDDGDFETVIDAIASGSIQPYLMITSKIRMEDVDERGFKALIEQRDTHVKILVDISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
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        </recommendedName>
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        <lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CRL21543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070916">
        <property type="term" value="C:inositol phosphoceramide synthase complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:inositol phosphoceramide synthase regulator activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:inositol phosphoceramide metabolic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Kei1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL21543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="38047" checksum="B893B122D9485C9A" modified="2015-09-16" version="1">MGFASRFLRIPRPESFLYVMSLETGASLITLSLLLNKISGLYGLLALLTGYHLSPVQLSMYLWSLVALGLAALLFPHIRKQSPLQCLALTYLYVFDSLINAAYTAAFGVTWFLVVSQHYDSGEAAGPGGDTIAQTAGFTSPKYDAAYVEIQNTKDGNNFVAHPPRAAEDLSNVVLQPESLPSIIFICLLWVIRIYFVLVMLAFARQALRLWVAIPRHTQLPTHSRNVSVASVADIDREPFSPYSPDGQGWQGKLGRVMISIGHSYWLGEEEDGNWLSGINHKFRNRSNNTELPGALERERRRRSGTGPPAPSPSIVRSTVLQQPIPEHAPGGMNVKMQDWTAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5G8</accession>
    <name>A0A0G4P5G8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">PCAMFM013_S006g000095</name>
    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Silar P."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793139">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P5G8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL21555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="56" mass="6093" checksum="825DCE3894151A22" modified="2015-09-16" version="1">MHKPLLAMCVTSLAAGVMIGNYFGGVRVTIIMKMVRLEYMEKASDANGSKVEFGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5R5</accession>
    <name>A0A0G4P5R5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DnaJ homolog 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S006g000191</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
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                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chaperone protein dnaJ 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
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    </dbReference>
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        <property type="entry name" value="Putative Mitochondrial DnaJ chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096:SF52">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="12">
        <location>
            <begin position="83"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="13">
        <location>
            <begin position="237"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="10">
        <location>
            <begin position="237"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="504"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="508"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CRL21651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="552" mass="58455" checksum="1973A77F3EAB9E68" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P622</accession>
    <name>A0A0G4P622_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcriptional regulator TACO1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S006g000320</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TACO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P622"/>
    <dbReference type="STRING" id="1429867.A0A0G4P622"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.200:FF:000002">
        <property type="entry name" value="Probable transcriptional regulatory protein CLM62_37755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00693">
        <property type="entry name" value="Transcrip_reg_TACO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048300">
        <property type="entry name" value="TACO1_YebC-like_2nd/3rd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049083">
        <property type="entry name" value="TACO1_YebC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR OF CYTOCHROME C OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532:SF0">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR OF CYTOCHROME C OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20772">
        <property type="entry name" value="TACO1_YebC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="YebC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TACO1/YebC-like N-terminal" evidence="4">
        <location>
            <begin position="36"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="TACO1/YebC-like second and third" evidence="3">
        <location>
            <begin position="114"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL21780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="30701" checksum="470466B6D1FC2B88" modified="2015-09-16" version="1">MALRLSRLLRQPRWVDSACHECRYFSTSSAILSGHNKWSTIKHDKARNDKAKSRERQIVGKEIASATQMWGPDTKYNPRLALALSNAKRASIPKIIIEAAIARGQGLSVSGQALESVTIEAMLPGSVAAVVECQTDQKARVLQDVRYMIKDNGGIVTPTTFLFERKGRVVMEKKDDADVDDYLDQAIEAGAADITTDDKGRLVVLTDPSETKTVGETFAKLSGLSIEELEIFWDPNRDSMVEVKDEEQVKDLEDLLSALREDPSVQDIYLNSVEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6E8</accession>
    <name>A0A0G4P6E8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S006g000438</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P6E8"/>
    <dbReference type="STRING" id="1429867.A0A0G4P6E8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="86"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL21898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="675" mass="75983" checksum="01C1FCF33711DD0D" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6G9</accession>
    <name>A0A0G4P6G9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vacuolar protein sorting 55</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S006g000461</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OB-RGRP/VPS55 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P6G9"/>
    <dbReference type="STRING" id="1429867.A0A0G4P6G9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034424">
        <property type="term" value="C:Vps55/Vps68 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007262">
        <property type="entry name" value="Vps55/LEPROT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050">
        <property type="entry name" value="LEPTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050:SF0">
        <property type="entry name" value="RH04491P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04133">
        <property type="entry name" value="Vps55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL21921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="128" mass="14036" checksum="00E3A7F80A63EE67" modified="2015-09-16" version="1">MAAGLKTIIALSFVLAIGFLLVILSSALWHRYWPLLVVGIYVVAPLPNWICQRCANPDDFMDSSSNSAMDFGRFLTGFLVLTGIALPIVLAHSGAIEIPAMIMSIFGGLLIYGTIISFSMFFQEQEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6J9</accession>
    <name>A0A0G4P6J9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate aminotransferase</fullName>
            <ecNumber evidence="7">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S006g000492</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="7"/>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P6J9"/>
    <dbReference type="STRING" id="1429867.A0A0G4P6J9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000066">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF20">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="8">
        <location>
            <begin position="30"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL21952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="407" mass="45023" checksum="8AC6457C15692B87" modified="2015-09-16" version="1">MATQYLDLQIAPADIAFGLMAEFEADPHPKKVSLIAGAYRNENGEPWILPSVKEAKQRLCETTHEYLGIAGSPTFTNLAKDLIFGSIASSLQDNAVSIQTVSGTGANHLAATFLARHLRPNRVFVPSPTWVNHKSIWEMTGVPVVEYPYYSPDTREVDITGMLDTLDQAEPNDVVILQACAHNPTGVDLSKAQWLKVSDLVQRKKVFTVFDSAYQGFATGDVDGDAWAVRHFVENVLASETHPGLCVAQSFSKNFGLYGERVGALHLVVPRHLSAKGALSELMLISRAEYSNPPRFGASIVETVLGDQGLRTQWKADLDTMSSRIQRMRGLLRQRLEKETLEDWSHVEKQIGMFSYTGLTEKQVSRLQKEFHVYMLPSGRMSVCGLNEDNIDYVVHAVGEVAKTGCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P709</accession>
    <name>A0A0G4P709_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable E3 ubiquitin ligase complex SCF subunit sconB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Sulfur controller B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Sulfur metabolite repression control protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S007g000015</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the SCF(sconB) E3 ubiquitin ligase complex involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SCF(sconB) E3 ubiquitin ligase complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P709"/>
    <dbReference type="STRING" id="1429867.A0A0G4P709"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25499">
        <property type="entry name" value="Beta-prop_pof12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="9">
        <location>
            <begin position="27"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="429"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="357"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL22034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="541" mass="60421" checksum="3D1F24980F9F89C9" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7D8</accession>
    <name>A0A0G4P7D8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S007g000212</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P7D8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL22231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="250" mass="29440" checksum="CC043FFE65D57582" modified="2015-09-16" version="1">MARKESFAGQSSILEPMKISSLLIDPPVCTSKSTVLPGSTQQLSDLSNQSIHFSKQNSRSHKYNDEEFWFIWYQHVVLDQGWENILESFNRQFPGRQRPRGKTLQSVYYRLTQRLKYLIGENASTESIIHHAKLSYPWMSNQVHISSETSFKGRRKYEDEEIWFIWWKRVALRKRWLDVLKSFNRKFPNGRSVSIHGIWSKLNREIKKKTLPHPCLVEAEEGSSHLDKVTSFITRKKLPYPWLLEALETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7M6</accession>
    <name>A0A0G4P7M6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCAMFM013_S007g000288</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P7M6"/>
    <dbReference type="STRING" id="1429867.A0A0G4P7M6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002167">
        <property type="entry name" value="GDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00928">
        <property type="entry name" value="GRAVESDC"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="38"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="137"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="245"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CRL22307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="336" mass="37016" checksum="D6963A1293920758" modified="2015-09-16" version="1">MSDTSISAPSAKKPSTKTEGSRHVYPTSKSNKDHRNLDVVLRNGLAGGVAGCAAKTIVAPLERVRILFQTSHSHFVQYSTRWDGFIQAARHIRTSYGIPALFKGHSASLVRVFPYAGINFLAYEQFRAAIITSSEKEAPWRRFLCGSMAGATSTLITYPLELIRTRLAFETVQNNPSSWLGISRKMYFEGGSGSLSNLYRGIAPTMLGILPYAGTSFLTHDLLRDWLRTPVLAPYTLEAPSSTRLTAVAQLSCGAVAGIVAQTISYPIDIIRRRIQVGSVVDTKSGILETAQRIFLERGVRGFYVGLTIGYVKMAPMVATSFYVYDRMKRFLGLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P862</accession>
    <name>A0A0G4P862_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial import receptor subunit TOM20</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Mitochondrial 20 kDa outer membrane protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial import receptor subunit tom20</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Translocase of outer membrane 20 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCAMFM013_S007g000476</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the Tom20 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P862"/>
    <dbReference type="STRING" id="1429867.A0A0G4P862"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016031">
        <property type="term" value="P:tRNA import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.960.10:FF:000002">
        <property type="entry name" value="Mitochondrial import receptor subunit TOM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.10">
        <property type="entry name" value="Mitochondrial outer membrane translocase complex, subunit Tom20 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002056">
        <property type="entry name" value="MAS20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023392">
        <property type="entry name" value="Tom20_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12430">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12430:SF0">
        <property type="entry name" value="TRANSLOCASE OF OUTER MITOCHONDRIAL MEMBRANE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02064">
        <property type="entry name" value="MAS20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037707">
        <property type="entry name" value="MAS20_rcpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00351">
        <property type="entry name" value="OM20RECEPTOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47157">
        <property type="entry name" value="Mitochondrial import receptor subunit Tom20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="35"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR037707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CRL22495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="164" mass="17889" checksum="FD2BE7CC75FD8D78" modified="2015-09-16" version="1">MAFRNTAIVAGTILTGVLAYAVYFDHKRQSDPNFRKSLKKNNKKVEQTVKQEAEAGAAARVAELKNALEQVKRNGELPTDLEEKESFFMSQVALGESLCASEGSQVEAAIAFWKALKVYPQPQDLIGIYDKTVPKETLEILAELIALDGGQSVGAKTGTDDNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P875</accession>
    <name>A0A0G4P875_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">isopentenyl-diphosphate Delta-isomerase</fullName>
            <ecNumber evidence="4">5.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S007g000507</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:23285"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IPP isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="4"/>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P875"/>
    <dbReference type="STRING" id="1429867.A0A0G4P875"/>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009240">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02885">
        <property type="entry name" value="NUDIX_IPP_Isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000012">
        <property type="entry name" value="Isopentenyl-diphosphate Delta-isomerase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011876">
        <property type="entry name" value="IsopentenylPP_isomerase_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02150">
        <property type="entry name" value="IPP_isom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885:SF0">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018427">
        <property type="entry name" value="Isopntndiph_ism"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="13">
        <location>
            <begin position="90"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CRL22526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="270" mass="30641" checksum="EC131D352D51B637" modified="2015-09-16" version="1">MSATTTITSPPEITADNVATLFPEVDTSLAREILPTSQTNTARGSELEGYDEEQVRLMDEVCIVLDNNDRPIGSASKKICHLMTNIDKGLLHRAFSVFLFDSNKRLLLQQRATEKITFPDMWTNTCCSHPLGIPGETGAELDAAIMGVKRAAQRKLDHELGIKAEQVPLDKFEFFTRIHYKAPSDGKWGEHEVDYILFIQADVDLKPSPNEVRDTTYVSADELKAMFEQPGLKFTPWFKLICNSMLFEWWSHLGTPALDKYKNEQDIRRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P8R1</accession>
    <name>A0A0G4P8R1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S008g000093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P8R1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL22664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="97" mass="10470" checksum="A274976B4FF07139" modified="2015-09-16" version="1">MEKGNIVSSASRPPSACDILQPLSHTCLLPSSGALAAQAREQQSENFALTAGSPTSSKASSSDAGEEVQKRNETIQQMCDEDDEGVRTWKRVVVEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PB95</accession>
    <name>A0A0G4PB95_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S009g000479</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PB95"/>
    <dbReference type="STRING" id="1429867.A0A0G4PB95"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF24">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL23539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="365" mass="41420" checksum="77FA9662AC825BFD" modified="2015-09-16" version="1">MFDSQCTFRVQIPALARSFPALLNAILAISARQMERKEGIQDSFDSLELYQEAIRLLSPLLQMHDPKVVAACVLLCCLEMMSARAQDWHRHLEGCAALFDAFEMNGFSSGLLQAVFWCYARMDLCGALISDGTQSTLLRPNKWLAPGCHEDDAAQLFEAARSPDMHANYAVYLCAKSCELVADRTQFLELAVQNDCTGEAFNHRWLRLWNDLQHWLDNRPPELLPIHTTTTKPFPRILFLQWAAISSNQLYHTACILLLNLMPKFIKLQPTPAMSALWHARRICGISLANPHHGCLNNAIQPLWIAGRLFSHVSEHAIIIDLIRHIEAETGWGACWRIRDLELAWGYRVSRSDRTIDGQRFPVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBM9</accession>
    <name>A0A0G4PBM9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S010g000133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PBM9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195547" evidence="1">
        <location>
            <begin position="18"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL23695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="103" mass="11150" checksum="5405823E1671C922" modified="2015-09-16" version="1">MKSISLIIAALAVGAFADLHTQGVCIDTPAKGVEVYNKAATEKACAAYKNRNTGSKQWDTCPDCTLLNEKDLLYYCESQAKHIGGDELHYYCTQNGAGDSVAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBN8</accession>
    <name>A0A0G4PBN8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protease-associated PA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S010g000176</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMEM14 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PBN8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PBN8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08022">
        <property type="entry name" value="M28_PSMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000008">
        <property type="entry name" value="Glutamate carboxypeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000101">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1740">
        <property type="entry name" value="Transmembrane protein 14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005349">
        <property type="entry name" value="TMEM14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044890">
        <property type="entry name" value="TMEM14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF46">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03647">
        <property type="entry name" value="Tmemb_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="904"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="9">
        <location>
            <begin position="228"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="11">
        <location>
            <begin position="420"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="10">
        <location>
            <begin position="671"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL23738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="929" mass="102213" checksum="25BC4FC0E7A492EC" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PC40</accession>
    <name>A0A0G4PC40_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S010g000315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PC40"/>
    <dbReference type="STRING" id="1429867.A0A0G4PC40"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019180">
        <property type="entry name" value="Oxidoreductase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039251">
        <property type="entry name" value="OXLD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21193">
        <property type="entry name" value="OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21193:SF3">
        <property type="entry name" value="OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09791">
        <property type="entry name" value="Oxidored-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase-like" evidence="2">
        <location>
            <begin position="152"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL23877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="271" mass="29513" checksum="4AA27C86CDD85B3E" modified="2015-09-16" version="1">MECLSAGTRHSLRRSVSQLRSFPGKTFPPFASYRQYVLVPTPRRMNGHSQSDQPDADNTPASLEEIADTPQAHPLSGYYSLILKSNSPYGGGTSTSRPTPARPEAKPTPASTVTPQSPQEKMAIVFGTRLAGPGRSSRYNPGEAPPESTWRTINGVPIPPQPEEPDNCCMSGCVHCVWDDFRDEMEDWASRIATAKAKGGPEKGTKDMRSAPRAEVRAASGSMDDDGGGSEANWTPPTEDNDLFANVPVGIREFMKTEKRLRVKHQKEASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCW3</accession>
    <name>A0A0G4PCW3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S011g000155</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PCW3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PCW3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195356" evidence="4">
        <location>
            <begin position="19"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="5">
        <location>
            <begin position="65"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="416"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="425"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL24161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="466" mass="50286" checksum="D7757C52A7146F4F" modified="2015-09-16" version="1">MHSGSWLFALLGVSLADALSLEKRHMPAVFNVPLKHNKVAKYAANTQLRRDNTVLLPIGNDENIVSTNISLGTPPQSIEVAFWMVGNECWVPVRTSHDCAMFRGNKNCNGSGGYNKTLSTSMNDLHSNFTVSKSIESSMTITGEFVTDTLVIGDTTVESMKIGILDVDATQNIIGLGYGETNSSFISLTEALVNAGTIKSPAFSMYMENPLHSISAGASQDEKTGTLLFGGVNRSKYNGTLHTLPIVNNPADYRKAFRVNMTNFSINETSVFSEGPSTQALLDASLSYTYVPESIAQDIFSRLGATETPTSGPASIPCNTTSSDTKLTFAFGAASFELDIGLFIERHGVFNDEDICYLGIVAKTDTKDADSVGLGANFLQQIYTVYDMGNDEISLAQRNWNSNEDEIVEITTGKNSVPGATLEKGVADDKESKDAHEEKSTGSRIDEGVGLRLSLSILVIWALFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDE1</accession>
    <name>A0A0G4PDE1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S011g000324</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PDE1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PDE1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF17">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G09900)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL24330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="293" mass="33246" checksum="1C1B23B08C7EBBF3" modified="2015-09-16" version="1">MDIDFHPGVNGSSPYVNFYPYTPSDTAGYAFMAMFGVATLFHLVLMFPFRAAFFIPLVLGGVCETFGYYGRAWSHKDRRNISSWALQEMLILCAPPLLAATVYMVLGRIIRSFDAEHLVRMSPKKITVIFVLNDVLTFCTQLGGAGVQVTGDENVMAIGKKVVLAGLIFSLVVFSFFIWIAVSLHRRLLRNPTDILVMNNINWQQYMWSLYAACFALMLRNLVRTIQFGASKDSALNQKELYIYVFDGFLMFFSMVVLGVYHPGLLIKKARRLAKVADFHEPLRMPDIQLTQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDL0</accession>
    <name>A0A0G4PDL0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Molecular chaperone, heat shock protein, Hsp40, DnaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S011g000338</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PDL0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PDL0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000013">
        <property type="entry name" value="DnaJ subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="10"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="159"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="159"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="387"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL24344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="439" mass="48098" checksum="2B39B272F8EAF457" modified="2015-09-16" version="1">MFSVATAGVDLYEVLEIHQSSTKDDIRKAYRKARREPRSSPYSSDTDIPEAEREEASIRFKAVQEAYDILYDDDKRHLYDTHGMSAFNGSGEPGMAGQPDLDDLLAQMFGGGMGGMGGMGGMPGMGGMGGMPGGRPNKPRKSPSEEQDYEVSLEDLYKGKTVRFSSVKNIICGHCKGKGGKEKATAKKCSTCDGHGHKEVLQRMGQFVTQQTVICTTCNGEGSYFAPKDKCKKCKGTRTTEAKKILEIYIPRGAREGDRIVLEGEADQVPDQEPGDIIFKIIEEEHPVFERAGSDLRATIEITLAESLTGFSRVVIKHLDGRGIELNHPLTAGAILSPGQVLKVPGEGMPMKRTDARGDLYLVVDVKFPDNKWNPTPEMLEKLKEILPKPSPPIQADTVDEVEYDPKGQMEEFGAQDGQDASAWEDEEDDDEPAQCAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PET1</accession>
    <name>A0A0G4PET1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S013g000029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL24787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PET1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195413" evidence="1">
        <location>
            <begin position="18"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL24787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="97" mass="10581" checksum="3496B4AA676A795C" modified="2015-09-16" version="1">MRVSALAFAAILSLVSAKKINMHCNFAEDHTGMVQQPFCCRDMAPARGNSKANEATDCDQLDQPQLCDDQSRPACCYTIGAKKICTGHVIFQDAEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PF74</accession>
    <name>A0A0G4PF74_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Intradiol ring-cleavage dioxygenase, core</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S013g000158</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL24915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PF74"/>
    <dbReference type="STRING" id="1429867.A0A0G4PF74"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018576">
        <property type="term" value="F:catechol 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009712">
        <property type="term" value="P:catechol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03461">
        <property type="entry name" value="1_2-HQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039390">
        <property type="entry name" value="1_2-HQD/HQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007535">
        <property type="entry name" value="Catechol_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050770">
        <property type="entry name" value="Intradiol_RC_Dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711:SF7">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04444">
        <property type="entry name" value="Dioxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catechol dioxygenase N-terminal" evidence="8">
        <location>
            <begin position="32"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="7">
        <location>
            <begin position="124"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL24915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="329" mass="37015" checksum="AC817139812175FD" modified="2015-09-16" version="1">MDPSKVKIPPMKDQTVDNITDNVITINSLCEDQRMKYVLERLVTHLHDFAREARLSSDEWMTGLRFLTEVGQICTDVRQEFILLSDVLGLSILVDSIDHPKPKGSTEGTVLGPFHTHDAEEMPAGDSMSHDPKGEPLLVVCTLRDLQGLPVEDVKIDIWETDSTGHYDVQYAGREGPDGRCIMRSDHTGVFWFKAITPVPYPIPHDGPVGKLLEKLHRHPYRPSHMHFMFEKEGYDHLITALYLRNDPYETSDAVFGVKDSLTVDIGKADAEIAKKYNVPEGHPLLTYDFVLVSDEETSKLRAHNSKVALDKLGRKVKIVNGLPVPDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PF82</accession>
    <name>A0A0G4PF82_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S013g000168</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL24925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PF82"/>
    <dbReference type="STRING" id="1429867.A0A0G4PF82"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016428">
        <property type="term" value="F:tRNA (cytidine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057285">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057286">
        <property type="entry name" value="PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023270">
        <property type="entry name" value="RCMT_NCL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="RsmB/NOL1/NOP2-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF1">
        <property type="entry name" value="RNA CYTOSINE-C(5)-METHYLTRANSFERASE NSUN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25376">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25378">
        <property type="entry name" value="PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02011">
        <property type="entry name" value="RCMTNCL1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="12">
        <location>
            <begin position="54"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="531"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="582"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="835"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="592"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="172"/>
            <end position="178"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL24925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="868" mass="96383" checksum="180A444F60E8EF9D" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PFF8</accession>
    <name>A0A0G4PFF8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-hydroxyacid dehydrogenase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S013g000280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
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            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
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    </dbReference>
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        <property type="entry name" value="7ALPHA-CEPHEM-METHOXYLASE P8 CHAIN RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL25195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="296" mass="33620" checksum="F94FE8220E1977A8" modified="2015-09-16" version="1">MTTAAFRYIDPVSYDPNATEPFKKPWGKVDGPGRSYQLTELERKVEDLRGQESDYTTDNSGFALYNSPAKETAFTDDAEVRGGYYAEVEELLRKKLPGVKKVAIFDHTIRRRTPGSARSPVQLVHVDQTPRAAEARVRRHLPEDEVEELLKGRYQIINVWRPIENPASDFPLALIDWRSIAPEDFVKVDLLYPKEWQENGEVAPDSESVFSTEGYEVKGETYAIAPNEGHRFFYAKDMTPEEVMFIKCFDSRSHTMTEGKTDIAHGSGHTAFFDPQTPAGSPGRQSIEVRCLVFYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="7">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">PCAMFM013_S014g000190</name>
    </gene>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793147">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PG36"/>
    <dbReference type="STRING" id="1429867.A0A0G4PG36"/>
    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Multidrug resistance protein D"/>
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    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF39">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05010)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="473"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="521"/>
            <end position="548"/>
        </location>
    </feature>
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        <location>
            <begin position="67"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL25294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="588" mass="64515" checksum="E7EC9E73C23A4E56" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGN6</accession>
    <name>A0A0G4PGN6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S015g000100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793148">
        <property type="protein sequence ID" value="CRL25514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PGN6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PGN6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF32">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="641"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="50"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="644"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL25514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="710" mass="80065" checksum="86B1E3D8D68E144C" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PHG3</accession>
    <name>A0A0G4PHG3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S016g000055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793149">
        <property type="protein sequence ID" value="CRL25774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PHG3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL25774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="57" mass="6636" checksum="35753D2781C76AA4" modified="2015-09-16" version="1">MSTFFDLPFRLIPERRFHSPLDGGPDKVLTGYSVGRGCVRHFPEVYLKNQKQLKARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PIG5</accession>
    <name>A0A0G4PIG5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S017g000188</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793150">
        <property type="protein sequence ID" value="CRL26205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PIG5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PIG5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431:SF7">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL26205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="205" mass="22308" checksum="FDA8EC71B5E99DA0" modified="2015-09-16" version="1">MTSMIPSPFLGGGQAIGISTDVSDSKSVNAAFDKIQAEYPSSKVAAAVFNPGGGFVVKPFLELKEEDYSNALKSQAQGAFNFAQRAIPLLLEARESSEYPPTLIFTGATASLKGSAKFAAFASSKFALRALAQSLAREFGPQGLHVSHTIIDGVIDIPRTKAWVFEHEDAKLSPDAIADSYWYLHTQPRTTFAFELDLRPYIEKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PIN6</accession>
    <name>A0A0G4PIN6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S017g000031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793150">
        <property type="protein sequence ID" value="CRL26048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PIN6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL26048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="87" mass="9620" checksum="9065D4069CD68699" modified="2015-09-16" version="1">MFSLARQFSGVRSKPQLFTSQKFTRSTQVPHRLSSNSPRSSPPRAPSAPQSSRSNFPIIPIILITAISSGAYIYLVKSRTGINTRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJN4</accession>
    <name>A0A0G4PJN4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S018g000263</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJN4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJN4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF4">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="4"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL26569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="312" mass="34244" checksum="938961676AF4D449" modified="2015-09-16" version="1">MAILAVSGGTGKLGRAIVEALKSQTSHSVFVLARSANDELSKTLGTPVISVDYSNVGSLGKVLEENRIDTIISTLPISDESAIDAQLNLIEAAIQSKSTNRFIPSEFGIIYDEAHAALFPPIKGKLLAAEKLKSSGLEYTLVSNGFFMDYYGLPRVKSYLQPFVFAVDIANSTAAIPGSGNVPVVFTRTFDVAQYVAALIGEEKWNERSIIIGDKLTWNDLVSLAETTKGAKFDVTYDREEKLRTFQVTELPSHPPVYPFLPKEQLQYILAVFGQWTEAGAFNLSDEDTLNKRFPDIKPLAMAELIQEAWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKH7</accession>
    <name>A0A0G4PKH7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ankyrin repeat-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S019g000110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKH7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PKH7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051616">
        <property type="entry name" value="Cul2-RING_E3_ligase_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224:SF64">
        <property type="entry name" value="IQ MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL26693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="889" mass="98668" checksum="AF5529C7A8CA0335" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKI8</accession>
    <name>A0A0G4PKI8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Exocyst complex, component Exoc1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S020g000079</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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    </evidence>
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        <submittedName>
            <fullName evidence="2">Cyclin-related 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S024g000135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793157">
        <property type="protein sequence ID" value="CRL27880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PNC1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PNC1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF117">
        <property type="entry name" value="PHO85 CYCLIN PHO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL27880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="364" mass="39561" checksum="FF671630C0A1025D" modified="2015-09-16" version="1">MLASSPSPSTAALRSPLPSTSGSHSHSHYEPTGAPQFNSPRSSRLAIDELRSALNRHTVDPSSPESSDLQRRRASSSTDTLKTLVHNSVLASTPQSAIFSAATATTPAAATSTNPPTSSPAPSMPAPTSGSNKRNSQRDHHSSDATPAEYDGEDLERSQSKRLRPSKPDVKMLPTQYELADPRDMVVLISSMLMELIRFNDKIPLHQGRLTRFHSRSPPRISVQDYLQRLTTHATLSPPILLSMVYYIDRLCALYPAFTVSSLTIHRFLITSATVASKGLSDSFWTNKTYARVGGIGMTELAMLELDFLFRVEWRIVPQPEVLVDYYQSLVDRCDGFEIEGVCQNGSAKAGVTGIAPAAGPVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNT2</accession>
    <name>A0A0G4PNT2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Oligopeptide transporter OPT superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S025g000180</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793158">
        <property type="protein sequence ID" value="CRL28122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PNT2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="387"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="528"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="554"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="638"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="680"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="706"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="784"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL28122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="848" mass="95213" checksum="2B515F9E020B3497" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PP99</accession>
    <name>A0A0G4PP99_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Haloacid dehalogenase-like hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S026g000137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793159">
        <property type="protein sequence ID" value="CRL28272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PP99"/>
    <dbReference type="STRING" id="1429867.A0A0G4PP99"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000131">
        <property type="entry name" value="HAD superfamily hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.240:FF:000001">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901">
        <property type="entry name" value="2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901:SF38">
        <property type="entry name" value="PSEUDOURIDINE-5'-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL28272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="291" mass="32328" checksum="F3F5571226D6B2D0" modified="2015-09-16" version="1">MASTNDLPRIRACLFDMDGLLIDSEDLYTIVTNEILQKYGRPTLPWSVKAQLQGRPQPEAVKIFNDFAQLPISDQELKEEQLTRQRHYFPQTKPLPGVPTLLSNLASTKSTDEPVYIALATSSHRGNYQLKTDHLTELFSVFPEPNKVLGDDPRIGQGRGKPLPDIYLLALETINIELRNQGKTEIKPEECLVFEDAVPGVEAGRRAGMQVAWCPHPGLLGAFKGREEEVLAGATGSHKEEEKTEAEKEAEELQAPRLQSSGTPGKIGDGFGQLYSTLEDFPYAKYGIRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPK9</accession>
    <name>A0A0G4PPK9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase, F0 complex, subunit F, mitrochondia, fungi</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S027g000016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793160">
        <property type="protein sequence ID" value="CRL28327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A0G4PPK9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PPK9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019727">
        <property type="entry name" value="ATP_synth_F0_fsu_mt_fun"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL28327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="102" mass="11111" checksum="D294D8107CE4DE27" modified="2015-09-16" version="1">MSYIARRGLSTLIPPKVASPNAIGAAQDAARMERVVTFYAGLPRGPAAAVKPTGLIGRYQARYFNGKNASGVPLIHAIGGILILGYSMEYYFHLRHHKNHPH</sequence>
</entry>
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    <accession>A0A0G4PPU0</accession>
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        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
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    </gene>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL28243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="34" mass="3827" checksum="0E736530707D41B6" modified="2015-09-16" version="1">MVRISNYYRSMWRDAADCCTARCPPWSTSGIAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQH1</accession>
    <name>A0A0G4PQH1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S029g000060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793162">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL28644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="123" mass="14417" checksum="873E2AB456BA4522" modified="2015-09-16" version="1">MYMMCLEFASIPNERDRYKCVLTKFVYGLDVSHIVPLKANKTAIKEQEQEWTWLGLFWSKERVDKSREAIVTGKSHEARMVIQRLENLISFNAPVHIFWGDALCALHPIVINEDKTYMEVAFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRD6</accession>
    <name>A0A0G4PRD6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S031g000128</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793164">
        <property type="protein sequence ID" value="CRL28960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PRD6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL28960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="136" mass="15293" checksum="736608CCD5AD399E" modified="2015-09-16" version="1">MPKNNTLPELFPREKGSGIRYLETDSSTKKHRRVSLACIECQKRKSKCSGTTPCTQCTTEARQCFYNPAGDRRSKAYTAELLKFRVTLYRMAAKLRSGTPEEISRLIWGIQNLPTDQDAVNYLVDGASLCGNLGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRL6</accession>
    <name>A0A0G4PRL6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Haloacid dehalogenase-like hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S030g000095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793163">
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    <dbReference type="STRING" id="1429867.A0A0G4PRL6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF4">
        <property type="entry name" value="ACID DEHALOGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL28808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="240" mass="26476" checksum="94AA47BC399F1458" modified="2015-09-16" version="1">MASNRNVVFDLIGTILSYENFFQAIDTRLGQKLRAEGIKPSLLGYTWIEVSEREYTYLSISKSYIPLTECMEKLFYRMLWMAGIEEPRAFANDEDLEFIMDGYQNLQVRPGAVDCVAKLHGAGFVVWGLTAGDLKHVNGCFARAGIDIPSGNILSCDSSGVGKPDPAAYSPVLKRLSKEDKPWFAAAHAWDVSAAKRTGFKAAYCSIWEKEAVPELFGPMDVAASNLPEMAEKIIAAECA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRL8</accession>
    <name>A0A0G4PRL8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S032g000110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793165">
        <property type="protein sequence ID" value="CRL29074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PRL8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PRL8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502:SF4">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="3">
        <location>
            <begin position="55"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL29074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="298" mass="33877" checksum="EC234F2AF066AB6B" modified="2015-09-16" version="1">MSLPGDPPSHPRGSYSLTDQHQSTPATATVTPNSKQLSEGITQEELDLKPWKYIALQDNISCLEAELEDIDHLCSRQEVPDENNGSFRYDTCQERVKCIWRIKDALEKYNSFVLQYTNIKTRAAATERDIDSLRNWLYNHEGAIVAEEQSYINKDDLFPLIPKERSPLRRLFEMSSRFRMSRFWKRKSVTSDLPTHCHETIQLYSDERIDIFVTFTSVVIGLAMLIAPIWILAYTAPVAAKLAIITAFILLFLALVSFGTNAKPFESLAATAALEVGNKLLCADIILIHFDANRNFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PS04</accession>
    <name>A0A0G4PS04_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S031g000076</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793164">
        <property type="protein sequence ID" value="CRL28908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PS04"/>
    <dbReference type="STRING" id="1429867.A0A0G4PS04"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF110">
        <property type="entry name" value="UBID FAMILY DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="56"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="304"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL28908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="446" mass="50289" checksum="D7130D917E8D7189" modified="2015-09-16" version="1">MGNVSPTPHQLLVEAVIFWSIGVVLYIGRILPVNVQYINPRDIMYAELLPFRFSHNSPAQSHIPGDDYVMTATFLMYTSLLILIQISAKYATNLMEPSEYDQVLSDPQQVHDRILGSKIVIALEQCMLFVTWGVKVCLLILYWRITKNLPSNLYVKILAAYVALGFVVIMVTYYAVYCRPFSQYWALPVSNLQCATYQHYSITQAVFNISSDAFVFAIPIPLIVKAKLPLHRKMLLLCVMSLGLFTIIAAILNKYFNFASPFTTVYQIWYIREASTAIFVANMMCWWPLLRKLFGVRAFQYHSTPGRPSRSTGNKETNPYSKAASSQSRASFSLTRPFHLSRPSFRSSAKGTALTGHSNAGNSSQDAINLPTGVIMEDPDRVDNIPLQVWGKGNERGTDVENLTTQQSIAKFEQRDHGTEVPLGDRIYCTHEFDIRSDSRSGHSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PSG3</accession>
    <name>A0A0G4PSG3_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD-dependent protein deacetylase</fullName>
            <ecNumber evidence="6">2.3.1.286</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S033g000038</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-acetyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-acetyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="6"/>
    <dbReference type="EMBL" id="HG793166">
        <property type="protein sequence ID" value="CRL29118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PSG3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PSG3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01408">
        <property type="entry name" value="SIRT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017328">
        <property type="entry name" value="Sirtuin_class_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF6">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037938">
        <property type="entry name" value="SIR2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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            <begin position="16"/>
            <end position="276"/>
        </location>
    </feature>
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        <location>
            <begin position="336"/>
            <end position="362"/>
        </location>
    </feature>
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        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
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        <location>
            <position position="146"/>
        </location>
    </feature>
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        <location>
            <begin position="44"/>
            <end position="48"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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        <location>
            <begin position="54"/>
            <end position="56"/>
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        </ligand>
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        </ligand>
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        </ligand>
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        <ligand>
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        </ligand>
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        <location>
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        <location>
            <begin position="242"/>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="362" mass="40265" checksum="65687BF164C182CA" modified="2015-09-16" version="1">MGNESSTQVDESTSPTVLEARNIEAVAKYVKQHNVKKVVVMVGAGISTSAGIPDFRSPDTGIYANLANLDLPEPEAVFDIGFFRQNPKPFYALAHELYPGRYRPTIVHSFVKLLYDKGMLLKHFTQNIDCLERQAGVPGEKIVEAHGSFASQRCIECKETFPDDEMHQMVSKGDVPNCHKCNGLVKPDIVFFGESLPSDFFDSRSLPEEADLCIVMGTSLSVQPFASLPSFVSPGVPRVLINMERVGGLGSRSDDVLVIGDCDAGVRKFAKAMGWGEELEALWEETNPDPQKRADENAPLQTRDERLQDEVDRLTEEVDRTLGLTDAYQNKVREKLESHDKAHRQSGDLDHVFPHLARKLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PTU4</accession>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
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                <person name="Debuchy R."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <begin position="26"/>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="72" mass="8151" checksum="D0AC53407E3AD97F" modified="2015-09-16" version="1">MLRVPSSLSVYLTNTWYPRDDLQKHNAVSCFVGCIPLGLGSLLAYGLTQMDGISGWWWIFIGRSCLSQRFHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PU67</accession>
    <name>A0A0G4PU67_PENC3</name>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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                <person name="Abraham A.L."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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            <end position="281"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="265"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="393" mass="44171" checksum="191213EA738E25F6" modified="2015-09-16" version="1">MPEDEPFPWDIGVHDAHCHPTDTLASVADIPQMKATTLTIMATRGEDQDLVQQTAVSLSAKESQSTTDRVVPCFGWHPWFSHQILDDTAQPTSAQNPAEHKSHYTAVLAPSPADDQQFIDLLPVPKPLSELISETRNRLQQFPNALVGEVGLDRSFRLPIPWTPADTDNRDDQLTPGSREGRRLSNYRVKPEHQRTVLKAQLQLAGEMNRAVSMHSVQAHGGVFEVLKELWAGHERVVLSRRKRDKQRDAEGAVSDDDDDDDEDKTPDGSQSTKASDFNGKSYRPFPPRICMHSYTGSVEPIRQFLHRSNPSDVYFSFSKVINFSGTAEKKVGDVIKALPEDRILIESDLHVAGAQMDELLEDVARQVCQLRGWELRHGVQVLADNWRRFVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUA4</accession>
    <name>A0A0G4PUA4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">YeeE/YedE family integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S041g000023</name>
    </gene>
    <organism evidence="10 11">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793174">
        <property type="protein sequence ID" value="CRL29881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046513">
        <property type="entry name" value="DUF6691"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp_TsuA/YedE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30574">
        <property type="entry name" value="INNER MEMBRANE PROTEIN YEDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30574:SF1">
        <property type="entry name" value="SULPHUR TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20398">
        <property type="entry name" value="DUF6691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195842" description="YeeE/YedE family integral membrane protein" evidence="9">
        <location>
            <begin position="21"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL29881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="34759" checksum="3C5DB18AA582E106" modified="2015-09-16" version="1">MFTPIHTTLGALLLFQGSSGLLIHNGAVFGISSILSGCVFNPSRDNVPIIAGLVSSIVPVYLLAPSLIPDYPAPPHSWASAAATLGVGLLLGWGTKNGRGCTSGHMLCGLSRLSPRSLIATAIFFTTALLTANFVEGGSNIPSCGTTPCYTPMYPSSPEFGFMAGAALLAAVTNFIVVPQKVHRSEESRVVYSYVAGLEFGLGLLISGMADPAKVLRFFAFVTDPSRFDPSLALIILFGIGPSLFTFLAEKPGQVVEKEKPVAKPTLAEKWRLPTATVSDIDWRFVAGAATFGLAWGLRGVCPGPAILRTVLQPTWGLITMGGYMLGNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUJ3</accession>
    <name>A0A0G4PUJ3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S045g000046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793178">
        <property type="protein sequence ID" value="CRL30180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PUJ3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PUJ3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="229" mass="25639" checksum="B224DFE24C610C84" modified="2015-09-16" version="1">MSQTVSQVIFFRVKPSVQPEDPDSEEGEALLRIFRTTQHQSGHEHSAWGRTAEDKDTIVWVVDWTDPRSTINVHHLEPFLAPENTQPPSMLHITFSPPLSCTETLTKNPVTELCTLSFPSDLDVLAVRQINADLINFRTTLVEQLPQSAGPRSWSMGHVDRPSKLPHEKSPSGQAFAHLLAVGWESMEAHLKAKETEKFIQSIAPLTEKMLAPIPGLEIKHVSFQKIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUN8</accession>
    <name>A0A0G4PUN8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S040g000070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793173">
        <property type="protein sequence ID" value="CRL29844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PUN8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL29844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="68" mass="7615" checksum="866C7A030D8ED3A2" modified="2015-09-16" version="1">MRECMLNKSVKVVERPGRGTEMVLFDVDPSKLRLELRKAHKAHNQTQPNPQMGWALGPTFGPTGGLWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUW8</accession>
    <name>A0A0G4PUW8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S041g000054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793174">
        <property type="protein sequence ID" value="CRL29912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PUW8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PUW8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL29912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="344" mass="37304" checksum="E5EEBDE5DE48C687" modified="2015-09-16" version="1">MSQTKILILGATGYIGGSILTDLQNSKNASQYSFSALVRNQEHASKLKARGVESIFFKSLDDLEIVKKAASEHDVVINAASASNDKAAAAIVQGLAERKERTGRAVNYIHTSGTSILGDQHISGKFVDRGIYSDATDDIYAYEKGRGPYGQRITDIVVIETGEKLNVPTYIVVPPTIYGEGSGPVATISQQVPNLAREAIKRKQAIVIGKGDGIWNHVHILDLAPLYTLLLEGILAGRQDIPSGRKGIFFAETGEHTWLDVSRGIAEALYARGLLPTNEVKEVSLAEAAHIAGGKEDLLEITLASNSRSRADLSRKLGWKPTRDDADFHKHYDEVIAAVAQEFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PV78</accession>
    <name>A0A0G4PV78_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S043g000059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793176">
        <property type="protein sequence ID" value="CRL30064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PV78"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL30064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="96" mass="10804" checksum="093758F33C1124E0" modified="2015-09-16" version="1">MQIVTSSSARNELVGFGVAIERQPPWYRKLRLKTLSLTLGVRAEQNLFSAELAAMAHILIMVVGVKDYRIMLLTSNKAAALTLRNPRQQLGQEFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVZ2</accession>
    <name>A0A0G4PVZ2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S052g000048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793185">
        <property type="protein sequence ID" value="CRL30491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PVZ2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL30491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="100" mass="11092" checksum="E4DDB45660372326" modified="2015-09-16" version="1">MDVVLEWRFNDRLPVFSSAPTCSAAQLFISTQDPTLAAQPQQGCPCFGWTLVTLGAPPHCSDVTSQSKQIQHDDIVALPAVDIEFENREPCPRHQLSLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PW75</accession>
    <name>A0A0G4PW75_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Maltase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S051g000022</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="HG793184">
        <property type="protein sequence ID" value="CRL30419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PW75"/>
    <dbReference type="STRING" id="1429867.A0A0G4PW75"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033934">
        <property type="term" value="F:glucan 1,4-alpha-maltotriohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000025">
        <property type="term" value="P:maltose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11333">
        <property type="entry name" value="AmyAc_SI_OligoGlu_DGase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000064">
        <property type="entry name" value="Oligo-1,6-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000087">
        <property type="entry name" value="Oligo-1,6-glucosidase IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000003">
        <property type="entry name" value="Probable alpha-glucosidase (Maltase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000007">
        <property type="entry name" value="Sucrose isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF179">
        <property type="entry name" value="NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="9">
        <location>
            <begin position="18"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL30419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="578" mass="66355" checksum="58803FCAD1D1E9E4" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PW95</accession>
    <name>A0A0G4PW95_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Immunoglobulin/major histocompatibility complex, conserved site</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S051g000042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793184">
        <property type="protein sequence ID" value="CRL30439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PW95"/>
    <dbReference type="STRING" id="1429867.A0A0G4PW95"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="8"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="94" mass="10919" checksum="AEC95CACC9160A12" modified="2015-09-16" version="1">MAHTIMPALPLELWGCITSYLSNSDIKNLRLTCVQFKNASILRIDRVFLSANPLNVKVFRCIAGHKKFRHSITEIIWRRAWPGAPRIQRIYRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PWQ5</accession>
    <name>A0A0G4PWQ5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Winged helix-turn-helix transcription repressor DNA-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S063g000008</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793196">
        <property type="protein sequence ID" value="CRL30902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PWQ5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PWQ5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="6">
        <location>
            <begin position="297"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="249"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="371"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="388"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="405"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL30902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="419" mass="46589" checksum="C7F75AB91BA7EF06" modified="2015-09-16" version="1">MTTPSNEESGDGRCQTIDNIVNNFISEHHDKSLRPLRLANISISEFSTELSNHLSVLNEGGSIALGRGEELTSKSLSLSLQSLFSITTPPVKEGPPLTWTRLVLFAGPQFEGPAEFEIGNSSVELSETDLKLLRSGRPWRFLFPWPDKDDCKKELQSNNTVLQELIDAQKTIGEVLEQISLVRRHLRNHRDLISRLSEDKHHANPRGEALPLDDASFSFSNGGSFDPVASAEYESSGYRYSPYTPTAIGYASNDRSSQPVDQDLNDPALSEGAFAGNSTQLDGSGPEKDARPGFRLHTSDFIQCLSEILDDPKNGDVMRWSENGQSVYVAPESKLPAHILTKMSTKSHQSLVRRLYYFGFHKTGGVFHHESFSRGQPSSIRPTRELSHSPSLPTPLRNSASQRGPRYKTIKRKRARESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PX06</accession>
    <name>A0A0G4PX06_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S063g000016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="149"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="205" mass="23236" checksum="A2EC635C51331566" modified="2015-09-16" version="1">MLEDNSRILQLNIMKLRAGMEDLTNDHQSQKLDVLLIQVPSITAYRTHVNHSAWRLYQPTAESDSVWFRSLIYTLIFSVYIAPVPMHTPDGASAEATLSAIHHTIQNVARDDSREPSALFWPGTSIAITQRGVTTTLNLDWSRTPATWINFIHDYDLQSCLPRGIATFWSLSHPGRNCTIDLTVTNTPDLLIKRHLYHGNYGSDH</sequence>
</entry>
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        <submittedName>
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        </submittedName>
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            <taxon>Eurotiomycetidae</taxon>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Dupont J."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:guanine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Azg-like"/>
    </dbReference>
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        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="XANTHINE/URACIL PERMEASE C887.17-RELATED"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Xan_ur_permease"/>
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    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3" id="KW-0813">Transport</keyword>
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            <end position="124"/>
        </location>
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            <dbReference type="EMBL" id="CRL30944.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
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</entry>
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    <accession>A0A0G4PY39</accession>
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        <submittedName>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
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                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">FM 013</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="F:chitin binding"/>
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        <property type="entry name" value="LysM1-like"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF18">
        <property type="entry name" value="LYSM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0843">Virulence</keyword>
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        <location>
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            <end position="18"/>
        </location>
    </feature>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PZ37</accession>
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        <submittedName>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793312">
        <property type="protein sequence ID" value="CRL31437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PZ37"/>
    <dbReference type="STRING" id="1429867.A0A0G4PZ37"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL31437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="228" mass="25417" checksum="DB52467E686F2930" modified="2015-09-16" version="1">MADHGGSRAPCHHNHAERHGDRLESEQTHAAPEPVELTNTGTSTGRVTTREIWQIIVHLQHTVEEQTTLIHATRTELREVKDNQNEHQTQNEKLQEEIAALRSQVNERNAPTPTRSWAAVAASTDNPQPRETRRQTDKDENCVRISTQRSTEVLGADNNGDAFGRYLPTPTANAHIRTALSKTLSTQDAQVTGIVATKTGYVIPVQEPGVGRNGPHQHRVADRAWQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NTJ9</accession>
    <name>A0A0G4NTJ9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S001g000395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NTJ9"/>
    <dbReference type="STRING" id="1429867.A0A0G4NTJ9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001447">
        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053710">
        <property type="entry name" value="Arylamine_NAT_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786:SF0">
        <property type="entry name" value="ARYLAMINE N-ACETYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786">
        <property type="entry name" value="N-HYDROXYARYLAMINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL17435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="292" mass="33682" checksum="FE0521A65547F246" modified="2015-09-16" version="1">MDTPKLASAYTPAQLTKYLNYIALPDQYAQYTNQPKSFPKTEEALKDLFRCQITRFPYDNLTCHYSTTQLAEIQPEKIYTTVIGGSESNPRSCRGGYCLEMGIFFHHILRGLGFSVYMTGGRSWDRIDGIPQGEFRGCPLPLISGQVTKNLGSQELRLIYDNIPKQTRKEQKVWIYQYRNAADKPWNSYYSFAELEFFQDDFEVMNRFTSWEAVEKRSFAVVKFIRNGETAGLPLLEGEVLENTDDVFVAGKIMMVNNAVKLNMGGRTRVIDSFETEDGRFEARKKWFSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NTN9</accession>
    <name>A0A0G4NTN9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glucose-methanol-choline oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S001g000373</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NTN9"/>
    <dbReference type="STRING" id="1429867.A0A0G4NTN9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF134">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="9">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="10">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="499"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="543"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="96"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="498"/>
            <end position="499"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL17413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="568" mass="62473" checksum="9BBC0D8D5127FEBC" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NUP8</accession>
    <name>A0A0G4NUP8_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S001g000760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NUP8"/>
    <dbReference type="STRING" id="1429867.A0A0G4NUP8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000060">
        <property type="entry name" value="Ubiquitin conjugating enzyme (UbcB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="2"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL17800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="152" mass="17259" checksum="A93D67023BDDF1E5" modified="2015-09-16" version="1">MGSIKRISKELAELTESPPEGITVELADESNVYEWKITMEGPEGSPYHNGKFLVKLSLPTEYPFKPPTVSFATKIYHPNVTNDEKGSMCLGMLRADEWKPSSKIAAVLQFARQLLSEPMPDDAVEGRIAEQYKNDRVRYEEVAREWTRKHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NUU3</accession>
    <name>A0A0G4NUU3_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydroxymethylglutaryl-CoA synthase</fullName>
            <shortName evidence="5">HMG-CoA synthase</shortName>
            <ecNumber evidence="5">2.3.3.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-hydroxy-3-methylglutaryl coenzyme A synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S001g000791</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10188"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.10" evidence="5"/>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NUU3"/>
    <dbReference type="STRING" id="1429867.A0A0G4NUU3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00827">
        <property type="entry name" value="init_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000008">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000590">
        <property type="entry name" value="HMG_CoA_synt_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010122">
        <property type="entry name" value="HMG_CoA_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01833">
        <property type="entry name" value="HMG-CoA-S_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323:SF2">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01226">
        <property type="entry name" value="HMG_COA_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase N-terminal" evidence="6">
        <location>
            <begin position="4"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase C-terminal" evidence="7">
        <location>
            <begin position="178"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL17831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="458" mass="50274" checksum="5FFA380EBE3E7CAA" modified="2015-09-16" version="1">MAARPQNIGIKAIEVYFPTQCVDQVELEKYDGVAAGKYTIGLGQTKMSFCDDREDIYSMTLTVLSSLMNKYNIDPKSVGRLEVGTETLLDKSKSVKSVLMQLFAPHGNTNIEGVDNVNACYGGTNAVFNSINWLESSAWDGRDAVVVCGDIALYAAGAARPTGGAGCVAMVIGPDAPIVVEPGLRASYLTHAYDFYKPDLTSEYPVVDGHYSLRCYTEAVDACYKAYDAREKTLKAQTNGANGATDESLSPLDRFDYILFHAPTCKLVQKSYARMLYNDFLANPSHPAFAEVAPELRDLDYEKSLTDKVVEKTFMGLTKKRFAERVNPGLQVATQCGNMYTATVYGGLASLLSNVAFDPKESKRIGLFSYGSGLASSMFSAKIVGDVSSMVEKLDLQNRLNARTILEPAAYDAMCKLREHAHLKKDFKPTGNTETIGSGVYYLTEVDDMFRRKYEIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NUZ7</accession>
    <name>A0A0G4NUZ7_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Delta(14)-sterol reductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">C-14 sterol reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Sterol C14-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCAMFM013_S001g000850</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM 013</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="14">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NUZ7"/>
    <dbReference type="STRING" id="1429867.A0A0G4NUZ7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050613">
        <property type="term" value="F:Delta14-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000008">
        <property type="entry name" value="C-14 sterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF52">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE TM7SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="8 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="13 15" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="9 15" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="12 15" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU369120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CRL17890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="496" mass="55615" checksum="67A2B7B186A21178" modified="2015-09-16" version="1">MSTKKDSKKIPVQPVPEKRGYEFCGPIGAFGIVFGLPTLIYLFTFVCNDISGCPAPSLLNPSTLSLEQLKREVGWPEEGVTALYDTNVTLWTLSYYAFSLFLQVFLPGQEADGVVLACGGRLKYKFNAFSSAIIILSGLAGGTYLYGADFVVWTFLWDNYVQVITANLLISSSVALFVYLKSFTVPAPGQANPSLRQLAPGGHTGNMLYDFFIGRELNPRVRLPIPFVSEASRTIDIKVFMEMRPGLLGWTILNLSNVAHQYRTYGYITDSIVLVTVFQAFYILDALYMEPAIMTTMDVIMDGFGFMLSFGDVAWVPHVYSIQTRYLSVFPYELGLSGMAVVLGITAVGYSIFRGANNQKNRFRTNPNDPRLKNIKYIETAAGSKLMTSGWWGLARHINYLGDWTMSWAYCLPTGVAGYVLIESINPASGAVQKQAVQTPEIRGWGMIFTYFYMLYFGVLLIHREMRDEEKCEKKYGADWKRYTSIVRSRIIPGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NW90</accession>
    <name>A0A0G4NW90_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin fusion degradation protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S002g000222</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UFD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NW90"/>
    <dbReference type="STRING" id="1429867.A0A0G4NW90"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.50:FF:000001">
        <property type="entry name" value="Ubiquitin fusion degradation protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.50">
        <property type="entry name" value="Ubiquitin fusion degradation protein UFD1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
        <property type="entry name" value="Ufd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042299">
        <property type="entry name" value="Ufd1-like_Nn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055417">
        <property type="entry name" value="UFD1_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055418">
        <property type="entry name" value="UFD1_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
        <property type="entry name" value="UBIQUITIN FUSION DEGRADATON PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555:SF13">
        <property type="entry name" value="UBIQUITIN RECOGNITION FACTOR IN ER-ASSOCIATED DEGRADATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03152">
        <property type="entry name" value="UFD1_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24842">
        <property type="entry name" value="UFD1_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 1" evidence="5">
        <location>
            <begin position="30"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 2" evidence="6">
        <location>
            <begin position="130"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="267"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="335"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="374"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00074895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL18352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="395" mass="42578" checksum="BC8762910BCD7328" modified="2015-09-16" version="1">MYRPGYWSDDPMDGVLGAGMPRPGATSRRFDEYYRCYPVAMLPGPERENVNHGGKVIMPPSALDKLTRLHITYPMLFELHNGAKERMTHAGVLEFIAEEGKIYLPFWLMQTLLLEPGDLLQIKSTDLPPGQFIKLQAQSTSFLDISDPKAVLENAFRNFSCLSKGDVFTFSYNDQVYEMAVLETKPSGSKNAVSVLETDLEVDFAAPVGFEEPQRASGTSTPGSVISGGKLPAGGLLHPHGTMAQSINYPAIAPDATDAATGARAASSNFLSGGQRLNAKKGSKAPTPNPSTPTPGSSNPSHPPPTRRTNGPQPLRLPPNQLFFGYAIKPVKPRDENGLVVPDDQPKFQGIGQTLRGKRKDLSDSATPSGSEAEGQKSKENTKKSDGGGRTLGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWG8</accession>
    <name>A0A0G4NWG8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA polymerase I specific transcription initiation factor RRN3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S002g000260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRN3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWG8"/>
    <dbReference type="STRING" id="1429867.A0A0G4NWG8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001042">
        <property type="term" value="F:RNA polymerase I core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007991">
        <property type="entry name" value="RNA_pol_I_trans_ini_fac_RRN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790:SF0">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IA RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05327">
        <property type="entry name" value="RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="327"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="659"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="327"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="664"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL18390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="689" mass="76815" checksum="26CFC7E45955C8D2" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWK2</accession>
    <name>A0A0G4NWK2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S002g000301</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWK2"/>
    <dbReference type="STRING" id="1429867.A0A0G4NWK2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
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        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="82"/>
            <end position="112"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="659"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
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            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="659"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="687"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL18431.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="696" mass="79232" checksum="867E78FD3AC78C8D" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWY3</accession>
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        </submittedName>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
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                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
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                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="29"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL18637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="74" mass="8911" checksum="7448372B57DA15EA" modified="2015-09-16" version="1">MSNNVEKTAVIPDDDEPDDWDKRIFSTGCHTEQDKMNDCYYAKKDWRECKKEMEAFRECWKRQGNDQRTQTKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NX05</accession>
    <name>A0A0G4NX05_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S002g000445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NX05"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL18575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="49" mass="5673" checksum="9FFC9BD08F174289" modified="2015-09-16" version="1">MTSGLRCLAPTFPAMSLRLRNVNASSHVFWLSYWMPSWAEWNAKNTVGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NX44</accession>
    <name>A0A0G4NX44_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Kynureninase</fullName>
            <ecNumber evidence="5 6">3.7.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Biosynthesis of nicotinic acid protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">L-kynurenine hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BNA5</name>
        <name evidence="7" type="ORF">PCAMFM013_S002g000379</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>L-kynurenine + H2O = anthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16813"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 6">Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 6">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the kynureninase family.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.3" evidence="5 6"/>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NX44"/>
    <dbReference type="STRING" id="1429867.A0A0G4NX44"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00329"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00334">
        <property type="reaction ID" value="UER00455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030429">
        <property type="term" value="F:kynureninase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097053">
        <property type="term" value="P:L-kynurenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000031">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01970">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010111">
        <property type="entry name" value="Kynureninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01814">
        <property type="entry name" value="kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KYNURENINASE"/>
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        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="4 5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
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    <feature type="binding site" evidence="5">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
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    <feature type="binding site" evidence="5">
        <location>
            <begin position="174"/>
            <end position="177"/>
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        <ligand>
            <name>pyridoxal 5'-phosphate</name>
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        </ligand>
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        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
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        </ligand>
    </feature>
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        <location>
            <position position="260"/>
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        <ligand>
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        </ligand>
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        <location>
            <position position="263"/>
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        <ligand>
            <name>pyridoxal 5'-phosphate</name>
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        </ligand>
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        <location>
            <position position="285"/>
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        <ligand>
            <name>pyridoxal 5'-phosphate</name>
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        </ligand>
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        <location>
            <position position="325"/>
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            <name>pyridoxal 5'-phosphate</name>
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        </ligand>
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    <feature type="binding site" evidence="5">
        <location>
            <position position="353"/>
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        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
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        <location>
            <position position="286"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
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        </source>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_03017"/>
        </source>
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        <source>
            <dbReference type="PIRNR" id="PIRNR038800"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="CRL18509.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="484" mass="54295" checksum="7D5691DA67FA3BE5" modified="2015-09-16" version="1">MGSRQHVRDIKSGSPLPYTDDIRAYKKEYAEALDAQDPLRSFRDEFIIPSKNDLKRKTLAVDESNEASDEKCIYFCGNSLGVQPRSTQKYIEQYLRTWATKGVTGHFVPHDDQLLPPFVDVDSAASKLMASVVGASQSEVAVMGTLTANLHLLMASFYRPTKEKYKIILEGKAFPSDHYAVESQLRHHNFDPKDGMVLIEPEDLDQPTLSTEKIIKVIDDNASSTALILLSAIQFYTGQYFDIERITAHAHSKGILIGWDCAHAAGNVDLQLHDWNVDFAAWCNYKYLNSGPGGIAGLFVHERHGSVDEKQPESDDTFRPRLSGWWGGDIKTRFNMENKFLPQPGAAGFQLSNPSVLDINAVVASLEIFNRATMKEIRQKSLNITGYLEHLLMKYPLDAAPEDKPFTLITPSNPAERGAQLSLRLQPGLLDHVLHCLEEKGVVIDERKPDVVRVAPAPLYNTYTEVWEFCQIFLQACKEAVKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NX64</accession>
    <name>A0A0G4NX64_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWR1-complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S002g000578</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SWC4 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DAMP1_SANT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="11">
        <location>
            <begin position="155"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
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        <location>
            <begin position="92"/>
            <end position="124"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="489"/>
            <end position="566"/>
        </location>
    </feature>
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        <location>
            <begin position="257"/>
            <end position="291"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
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        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
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        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
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        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
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        <location>
            <begin position="507"/>
            <end position="517"/>
        </location>
    </feature>
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        <location>
            <begin position="529"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006918"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00019132"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL18708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="566" mass="64217" checksum="9E88B42A251EF80C" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZS0</accession>
    <name>A0A0G4NZS0_PENC3</name>
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        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S003g000348</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CRL19557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL19557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="235" mass="26213" checksum="B8AE61472BDE545F" modified="2015-09-16" version="1">MFLDHRRPGGSAVAGHRKTLACLESLPVDHVHYRLSKSTIPSRAFPVDLVQQTESGLPSRSAATTRSQSSRAKVLLRKYEECCTMVPKLGRRIGRARAMLDLVENVPVVCSGNSFSVIADKDIQLVRAIWHQLYDRLGLDVPFSRFASSGNCTAAGRRLTFGNCQERCDQGPQLKKRIERCQDAIQLIRLQSLSMDCVLGDNEIAFHQDVWLRIYSRLGLEIPFPGFSNGQADNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0J8</accession>
    <name>A0A0G4P0J8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S003g000639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4P0J8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13917">
        <property type="entry name" value="zf-CCHC_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL19847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="287" mass="32910" checksum="E6AD86B0BFB4C345" modified="2015-09-16" version="1">MNRYRNAPKLGGSNSNRATATTLCQKCLGRDIFDCKASAQERPYIPRPSRTQQLLNPELMPKLSSENPNELLRKEGVADELLATREEERGRKRDLDDMTDRNAQSPKWARSLSVETISTNRSYSSSPRRNKHGTADRGRRDDSSAPPAKSRKRRYSDSTEGSSGSVHSGPKNRSPSRERTDDRNTRRRRRESSPEERGRHRGSERHSERRDRRSKSADKDRVKESRATTQDVPRDRSYRDRASPPHQSQPGRSRPEPITQKNQPPRERSLSPFSKRLALTQAMNNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0L6</accession>
    <name>A0A0G4P0L6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S003g000653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P0L6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL19861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="131" mass="14783" checksum="50670710EBA6600A" modified="2015-09-16" version="1">MGQLTENAERLRQEIKSLLPDARECDRNEPGDISFSKDRQGNTLYAGAVLKAKVEGLVREMKIGEGWGWNLAIFPVTRLVKNELKQMYLVPLSEAALLGPVERKLKEGYSYYIQHLPVLNPGVAIIFITRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0M5</accession>
    <name>A0A0G4P0M5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S003g000674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P0M5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL19882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="162" mass="18828" checksum="FC8FFC40DA2470FF" modified="2015-09-16" version="1">MPFFQPSVFQSSQFEHGHRFHFKDPHNSQPGWIWGNVALPPTMGMDTSDLEIIVHVCDTITQNLVGWSDTAQHGMGKYCVSFPIKMETPPQDKKRLMFQVEYAALWWVNLVRAGTVSIDKHFLFRACQAPVYPEDRLLDVPLHWRKPEYMVLDPWSVVTELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P153</accession>
    <name>A0A0G4P153_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline monooxygenase, chloroplastic</fullName>
            <ecNumber evidence="5">1.14.15.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S003g000850</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the first step of the osmoprotectant glycine betaine synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>choline + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = betaine aldehyde hydrate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:17769"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15870"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.14.15.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (monooxygenase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the choline monooxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.7" evidence="5"/>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL20057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P153"/>
    <dbReference type="STRING" id="1429867.A0A0G4P153"/>
    <dbReference type="UniPathway" id="UPA00529">
        <property type="reaction ID" value="UER00430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019133">
        <property type="term" value="F:choline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019285">
        <property type="term" value="P:glycine betaine biosynthetic process from choline"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00680">
        <property type="entry name" value="RHO_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03469">
        <property type="entry name" value="Rieske_RO_Alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015881">
        <property type="entry name" value="ARHD_Rieske_2Fe_2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756:SF5">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00570">
        <property type="entry name" value="RING_HYDROXYL_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="15" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="14">
        <location>
            <begin position="65"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CRL20057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="373" mass="43182" checksum="876C3FE31B14CB27" modified="2015-09-16" version="1">MTSTLVSLFGYKPDDGAGTPQAPEEPLKALPASWYRSPGMYELERRAIFSKKWILTTHKLRFECNLNGLHNLCRHRAFPLVSQDEGNISIFSCKYHGWSYGLNGKLAKAPKFDDVPGFKKEEQSLFPVHIHVDVLGFIWVNLDFSPTPIPWEEDFQGVDTQERFGQFDFSRYRLDHTWQMDGNYNWKTLADNYNECYHCSVAHPDVAKLADLSYYYAVSKPGHIQHFSRPKKDKVEGDIKNASTYYFPNACMTVSPQIFYLMRCVPTSVRTCSMEYEVYRHMEASDEDFNHIDSFFKHAGVFVNGQLHPYLESAPLFFQNTVRGLLRTHRDEEKREKRELWPARQRSADSVTAVDSDFCAELACDGKSSELEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P1E4</accession>
    <name>A0A0G4P1E4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Flap endonuclease 1</fullName>
            <shortName evidence="15">FEN-1</shortName>
            <ecNumber evidence="15">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PCAMFM013_S004g000082</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
            <location evidence="15">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
            <location evidence="15">Nucleoplasm</location>
        </subcellularLocation>
        <text evidence="15">Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14 15">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="15"/>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A0G4P1E4"/>
    <dbReference type="STRING" id="1429867.A0A0G4P1E4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09907">
        <property type="entry name" value="H3TH_FEN1-Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PIN_FEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF9">
        <property type="entry name" value="FLAP ENDONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 15" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 15" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 15" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 15" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 15" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="18">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="17">
        <location>
            <begin position="146"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="348"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="378"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="HAMAP-Rule" id="MF_03140"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
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        </source>
    </evidence>
    <sequence length="395" mass="44616" checksum="99B51D02FAEDD1DF" modified="2015-09-16" version="1">MGIKHLYQVISENAPDAIKTGEIKNHFGRKVAINRSMSIYSFLIAVRSEGQQLMSESGETTSHLMGMFYRTLRMVDNGIKPLYVFDGAPPKLKSGELAKRVARKAEATEAHEEAKETGTAEDIEKFSRRTVRVTREHNAECKKLLGLMGIPFINAPTEAEAQCAVLARAGKVYAAASEDMDTLCFESPILLRHLTFSEQRKEPIQEIHLDRALEGLDMDRPQFIDLCILLGCDYLEPIPKVGATTALSLIKEHKSLEKVLEFMKNDPKKKFVVPEDWPYEDARELFVNPDVRPADHAECDFKWEAPNIEGLIEFLVGDKGFNEDRVRNGAARLSKHLKTAQQSRLEGFFKPVARTEDEKASLKRKHDEKLQQQKKKKKEDAKAKKEAKAKPRGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P1X6</accession>
    <name>A0A0G4P1X6_PENC3</name>
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        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">PCAMFM013_S004g000208</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
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        </location>
    </feature>
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        </location>
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        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="863" mass="83398" checksum="28383EAB8A9317DF" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P290</accession>
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        <submittedName>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Dupont J."/>
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                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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            <end position="473"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="492" mass="55009" checksum="E0C9A13FCE393D1A" modified="2015-09-16" version="1">MSKQLPFSTVEVKPHNRFSARNLALVIASAGLLATGYNFSHHSWSLGDQKLLAPDQSVWNDADNPARVKTFQQCAIDNLLETGLPFMKNVAPIAVADFEERRDRLAQALVAEGADAFVVEPGYTFKYYGNVSQPEWEVWEPEERPFLMVIHPFHDKATGNVKANTTFLCPSFEAERARLLGMPFSEEISIVPWEEHWDPYATLWQSDVFMGLRQPARLMVDEEMRDFIQRGLGSAGFEIIGLQGQVEEVRQIKTAREVEILRAVNTGTVEAVRQMRKCLYPGLTENEITTALDDTLRAAGLDPFFDIVLFDENASNPHGGTNGSKVLEAETFVLIDVGAHLYGYSSDICRTFFPPFLQKPSKRDVLSPRMSEKLKVWDIVFEAQTRSIDQMRENMTAASVDIAARDVISHAGYGEAFTHRVGHGIGIKAHESPYMNQGNTASLLKTGMTFTSEPGIYLVDKFGVRHEDVLLVQGDGKPRLLTGSRARGPWEP</sequence>
</entry>
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                <person name="Dupont J."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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            <end position="78"/>
        </location>
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            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL20493.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="78" mass="9030" checksum="BA0A4B74D9E60808" modified="2015-09-16" version="1">MVGVWETARPMKHRDTPERLPPSQPRYAIPLKQRSLQKWRQSELVWKPGPPPRSSTQCRTDHSKADLSFNNTSPNVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P362</accession>
    <name>A0A0G4P362_PENC3</name>
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        <submittedName>
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        </submittedName>
    </protein>
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                <person name="Dupont J."/>
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        </citation>
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        </source>
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            <end position="146"/>
        </location>
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            <end position="167"/>
        </location>
    </feature>
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            <end position="217"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL20688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="572" mass="63756" checksum="6A1954789E091FF8" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3A1</accession>
    <name>A0A0G4P3A1_PENC3</name>
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        </submittedName>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
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                <person name="Lacoste S."/>
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                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="25"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL20733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="386" mass="44173" checksum="93921BB7C5F23A09" modified="2015-09-16" version="1">MHFLSRVKTVLRKGKRDSISARPKASPWKRLPSHVFVKILASCDLKDIGSLSLSCRALHDRVSKLEYAIAWAYIQLRKQMHHQRHCIDGGLSPGDDIAFISELFPPPPPEYSTDMPHDNAEYSLGYLGDLKRCWNTCIRLSHHLAAHVVEHHLETDTIAQPLWSSSKTEKEVVYSKAVASLQAKLLYPIAYAVFFLESSASSDSDSGHSGHHHKNMACSIERQQTILRNAPFDDTLIFLSTHHCMQLLFSTVQRLMGPEIPHSTAESWFSLLLTTSTMERILNFFISIGKDDQIKQKGEHDSTWSHRKEFLWAMRQDLDEYMASFSDHSEQTLLDPKLNHVWFQAARNEMDERGAIPHTVEDSEVHVLHGSVVKLECEYCYDCYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3I1</accession>
    <name>A0A0G4P3I1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome production factor 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ribosome biogenesis protein RPF2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S005g000028</name>
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        <lineage>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <location evidence="1 4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the RPF2 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4P3I1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039770">
        <property type="entry name" value="Rpf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728">
        <property type="entry name" value="BRIX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728:SF0">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="6">
        <location>
            <begin position="28"/>
            <end position="245"/>
        </location>
    </feature>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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    </dbReference>
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    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P457</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        </source>
    </reference>
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            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
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            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
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        </reaction>
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    <comment type="similarity">
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    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01667">
        <property type="entry name" value="TGS_ThrRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00860">
        <property type="entry name" value="ThrRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000019">
        <property type="entry name" value="Threonine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000003">
        <property type="entry name" value="Threonine--tRNA ligase 2, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000005">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047246">
        <property type="entry name" value="ThrRS_anticodon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF46">
        <property type="entry name" value="THREONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="15">
        <location>
            <begin position="74"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="309"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="582"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="582"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CRL21053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="744" mass="84972" checksum="D0E0FE7ACF5F58E3" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P472</accession>
    <name>A0A0G4P472_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S005g000305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P472"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL21141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="102" mass="11575" checksum="5AB9ADDB7BA5C5C0" modified="2015-09-16" version="1">MEFVRTLYYRGIVDVLCTGPARVIQVAYVTLRVLVHLQEHDIQNDNGAYKKGIGTKLRGLSGTAEYLAVRVGLRTVFDSYSRDARVIEIARLEEKKSIYITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P4I0</accession>
    <name>A0A0G4P4I0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4</fullName>
            <ecNumber evidence="6">3.1.13.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Carbon catabolite repressor protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Cytoplasmic deadenylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Glucose-repressible alcohol dehydrogenase transcriptional effector</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">PCAMFM013_S005g000347</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="23">Acts as a catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="6"/>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P4I0"/>
    <dbReference type="STRING" id="1429867.A0A0G4P4I0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09097">
        <property type="entry name" value="Deadenylase_CCR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000037">
        <property type="entry name" value="Glucose-repressible alcohol dehydrogenase transcriptional effector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000447">
        <property type="entry name" value="Glucose-repressible alcohol dehydrogenase transcriptional effector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF100">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="26" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="13 26" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="16" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="25">
        <location>
            <begin position="384"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="97"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="24">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="120"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="202"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00030493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00031469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00033317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00045495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="CRL21183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="750" mass="84265" checksum="C605FE34E8A86C62" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P4U4</accession>
    <name>A0A0G4P4U4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonuclease III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S005g000488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P4U4"/>
    <dbReference type="STRING" id="1429867.A0A0G4P4U4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="1">
        <location>
            <begin position="18"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL21324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="154" mass="16938" checksum="C252C8AE5BBE1859" modified="2015-09-16" version="1">MVGRYIFALPSLPSDEDLQVFEEKIHYSFANDALLREALQVPSGFNGDGNKRLALIGDKILGLILARSGRNKNRTIGETTKMINARAVNAHLAKQGFVLGIDIFIVKNPCQCDIMPKVMADTMQAIIGAVYTDCNEQIQPCVDVMTVLGLSWPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5U1</accession>
    <name>A0A0G4P5U1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Carbon catabolite repressor A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PCAMFM013_S006g000184</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Transcription regulator component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Represses the transcription of the alcR, alcA and aldA genes by binding to a GC-rich region in their promoter. Also plays a role in response to carbon starvation and the control of extracellular proteases activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with creB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the creA/MIG C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P5U1"/>
    <dbReference type="STRING" id="1429867.A0A0G4P5U1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000433">
        <property type="term" value="P:carbon catabolite repression of transcription from RNA polymerase II promoter by glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043609">
        <property type="term" value="P:regulation of carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000089">
        <property type="entry name" value="DNA-binding protein creA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000152">
        <property type="entry name" value="DNA-binding protein creA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051007">
        <property type="entry name" value="creA/MIG_C2H2-ZnF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428:SF1">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="90"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="253"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="390"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CRL21644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="411" mass="44283" checksum="CB4C17D10003E6A5" modified="2015-09-16" version="1">MPPPASSVGFSNLLNPHDTSPDSTPSTPGDSSMASSVSLLPPLMKGARPATEEVRQDLPRPYKCPLCDRAFHRLEHQTRHIRTHTGEKPHACQFPGCTKRFSRSDELTRHSRIHNNPNSRRSNKAQHLAAAAAAAGQDTGMVNPANMMPPPSKPITRSAPVSQVGSPDVSPPHSFSNYANHMRSNLGPYSRTNERASSGMDINLLATAASQVERDDHMGFHGSRGHQIFGSRHHGTSRGLPSLSAYAISQNMTRSHSNDDDDGYGHRVKRSRPNSPNSTAPSSPTFSHDSLSPTPDHTPLATPAHSPRLRPLGASELHLPSIRHLSLQHTPALAPMEPQPEGPNYYSPTQGHMGPTISDIMSKPDGTQRKLPVPQIPKVAVQDMLNPAAGFSSMNSSANNSVAGGDLAERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5W9</accession>
    <name>A0A0G4P5W9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="8">ATase</shortName>
            <ecNumber evidence="3 8">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S006g000251</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H2O</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="3 8"/>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P5W9"/>
    <dbReference type="STRING" id="1429867.A0A0G4P5W9"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00715">
        <property type="entry name" value="GPATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035584">
        <property type="entry name" value="PurF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11907">
        <property type="entry name" value="AMIDOPHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="12">
        <location>
            <begin position="2"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="547"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="554"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL21711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="580" mass="63150" checksum="41A0353DE5840C1B" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6A0</accession>
    <name>A0A0G4P6A0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hydantoinase/oxoprolinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S006g000370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4P6A0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049517">
        <property type="entry name" value="ACX-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF23">
        <property type="entry name" value="HYPOTHETICAL 5-OXOPROLINASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19278">
        <property type="entry name" value="Hydant_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="4">
        <location>
            <begin position="11"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="2">
        <location>
            <begin position="214"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Acetophenone carboxylase-like C-terminal" evidence="5">
        <location>
            <begin position="544"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="3">
        <location>
            <begin position="725"/>
            <end position="1239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL21830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1356" mass="148668" checksum="758A3E568F2B4307" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6F1</accession>
    <name>A0A0G4P6F1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">alcohol O-acetyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.84</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Alcohol O-acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S006g000443</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Displays enzymatic activity both for medium-chain fatty acid (MCFA) ethyl ester synthesis and hydrolysis (esterase activity). MCFA are toxic for yeast and this enzyme could thus be involved in their detoxification by esterification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aliphatic alcohol + acetyl-CoA = an acetyl ester + CoA</text>
            <dbReference type="Rhea" id="RHEA:17229"/>
            <dbReference type="ChEBI" id="CHEBI:2571"/>
            <dbReference type="ChEBI" id="CHEBI:47622"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.84" evidence="6"/>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P6F1"/>
    <dbReference type="STRING" id="1429867.A0A0G4P6F1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008126">
        <property type="term" value="F:acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004026">
        <property type="term" value="F:alcohol O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051792">
        <property type="term" value="P:medium-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000137">
        <property type="entry name" value="EEB1p Acyl-coenzymeA:ethanol O-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF63">
        <property type="entry name" value="ALPHA_BETA HYDROLASE 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="10">
        <location>
            <begin position="170"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00066969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00080774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL21903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="485" mass="54146" checksum="E64695E07EE95FE2" modified="2015-09-16" version="1">MLDIISTLLNSIPLSVLLSGLIAMGLISWFRPKGRIAFYHAKDNKLTLTKVPGATGAKEQTTFVDICRSATPETCNLNPFLFNGHLQTCWTTLKYDNVPVYYKRKMFESETPAFTGHYAMDFVVAPYEIPQDPELIDQARKYTQKSGMPPRTSFFSQDEFAALPSDDTKPMLVLLHGLSGGSHEVYLREVLAPLVKDGAWEACVVNSRGCAETNISTGVLYNARATWDVRQSVKWLRKQFPNRPLFGIGFSLGANILTNYLGEEGDACQLKAAVICASPWNLDIGSLMLQSTWIGKEVYSRTMGTSMKKLFEAHVDQVSTNPRIDVDAIRKITYLHEFDRALQCPTWGYPTEGAYYRDATSTDSMLAIRIPFLCVQAEDDPIACREALPYQEMTQTPYGVMLTTSWGGHLGWFELGGSRWFVKPVANFLNKMAREIDTNIPGVVEHPERLPGNIASHPGANKEPDLAPKPEFVSMRRKLALPLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6R0</accession>
    <name>A0A0G4P6R0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S006g000558</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL22018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P6R0"/>
    <dbReference type="STRING" id="1429867.A0A0G4P6R0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Starter acyltransferase (SAT)" evidence="2">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL22018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="124" mass="13458" checksum="E34E2359698A2CEF" modified="2015-09-16" version="1">MPRHMQDAFPPPQSIMAWNENLEDLQTSLAGGALERALLCVLELGMLVGHYESQGVLYDLPVSDRMVLAGMSIGLFSAAAVATSSFLFELAHTGSTSVRVAFRFGLHVGQVSHMLEPRGEVRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7K4</accession>
    <name>A0A0G4P7K4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">catechol O-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S007g000282</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.6" evidence="1"/>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P7K4"/>
    <dbReference type="STRING" id="1429867.A0A0G4P7K4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006584">
        <property type="term" value="P:catecholamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836:SF2">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0128">Catecholamine metabolism</keyword>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL22301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="365" mass="40848" checksum="10169CF6FA7F5525" modified="2015-09-16" version="1">MDKGIFTKYPSLKKMEGLDDEDIVESHDGREVTLLKYIYNHPDLDTKLRGSPSAILAAMDEFAAQEDFLINIGSDKANKLAVLIREHCPRVLVELGGYVGYSAILFGNILKEIRAQDKPHPKDDEESGATKLKLYSVEIDPLIASVAMNLVSLAGLQDIVEVIVGASQHTLQRFHDEGILAETGIDLLFMDHDEALYEPDVKLAEKLGFLDKEGALVIADNVLRPGAPEYRSYMRKNPRLSKSWGLPGLIVPGDFEYGVRGGITASIKVTTDRLIQKVIRENFKECTVITITDRLDTILDSDRILLLHYGEVVEFDSPSNLLGRASRFKAFYEAVGCQYIYENSSVVSLYPEEFWCKRSTHFGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7L5</accession>
    <name>A0A0G4P7L5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger, CCHC-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S007g000276</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P7L5"/>
    <dbReference type="STRING" id="1429867.A0A0G4P7L5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051714">
        <property type="entry name" value="Znf_CCHC_NABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23002">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="95"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL22295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="153" mass="17501" checksum="B107EB1CE86CE4E3" modified="2015-09-16" version="1">MKARGSMEDGSKPWDVRRRRQWCHEFMKPNHFSICKHAPTCHQCGEKGHLKRDCLPKKRKREEKPKSGSMKLETCFKCGKKGHMKYDCPQAEPTCFTCGQTGHFKSNCPQKNSKHPGDSPNLFAPVQDSPQSTQITFKARLQFLLLLSSPLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P846</accession>
    <name>A0A0G4P846_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Synaptobrevin homolog YKT6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S007g000489</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P846"/>
    <dbReference type="STRING" id="1429867.A0A0G4P846"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000017">
        <property type="entry name" value="Synaptobrevin-like protein Sybl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051097">
        <property type="entry name" value="Synaptobrevin-like_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136">
        <property type="entry name" value="SNARE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136:SF168">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="11">
        <location>
            <begin position="10"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="156"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL22508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="251" mass="27865" checksum="531BE5761EF83D84" modified="2015-09-16" version="1">MASSSKTSSLLYSCIAHRTTILAEHSSPGSSSSAASSLASIILPKISHDKPQKLTFTHERLFVHYIADSPTGNQSDDANLAEPNSHAPLSFVVVASAEQGRRIPFAYLLEMKRKFLTTYEPSTTEFASLPAYGCAAFNNELRSLLQAYNTAPPADSLASARREIDSVRDIMTENIERVLERGERIDLLVDKTDRLGGSAHDFRIRSRGLRRRMWWKNTKLMIMMVVVVIFLLYLFIGMGCGLPAWGKCVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P8F6</accession>
    <name>A0A0G4P8F6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S008g000019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P8F6"/>
    <dbReference type="STRING" id="1429867.A0A0G4P8F6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38886:SF1">
        <property type="entry name" value="NACHT-NTPASE AND P-LOOP NTPASES N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38886">
        <property type="entry name" value="SESA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL22590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="236" mass="27290" checksum="B416254DDFFE8D45" modified="2015-09-16" version="1">MSFGLSIGDIILCSQITYRLLAAATSGRKNAPIGLRELEDTLFGLNYSLSHLQRASNTVLSRSNYDAGDIHRQLGFMIRSCRQTLETLEKATAKYRETAKKPVPMPQSYKGLKFCSQHKFTTQVKIQWRRFIWDLKGESLSRYRRKLESHTDAINLLLVTCIWTATDRIEENDRRQEQRMEELLRQASHFNGELFHLIQNLYPPTLTHRSCTLSERITSNTLSAFESTSSQPRCRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P9K6</accession>
    <name>A0A0G4P9K6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S008g000409</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P9K6"/>
    <dbReference type="STRING" id="1429867.A0A0G4P9K6"/>
    <dbReference type="Proteomes" id="UP000053732">
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="OAF3"/>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF31">
        <property type="entry name" value="MONODICTYPHENONE CLUSTER TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="21"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL22980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="422" mass="45996" checksum="C46259B7786A3CAD" modified="2015-09-16" version="1">MLAESNGSPYAGGDTPKLRTACENCRQSKVKCNLSGKSVCTRCLRHGLQCQYGFANRSGKPKGSKNRATLRKLGQLQEEKPTMRGFRGSRLVAPVADMEPLVGNSYGSQIPDPAIDNDPGFWESPRSFGNTTTLESSVCPGQLTTVESSPFTDLVDPCPTLPAGLGYPHTPVTPTFLSGELADGMASPSLAGSVASPYPISPCECVDMQLFHMNRLNHLLAGSMPLRLDHSLQTIKCTFCACQMFLQCTKCPKDSTNLLLTISVLNLTLQLFEYWVSRETSRAPRPEHGVDIRYGYYEICHEESRQIRNFLLRGLLLQCRDVLLALKSTASAADVQIPKLGDHEGPSEPRLSDEHASQHWALSEHVGLLPDLDSDFPSGTPRSEGLLSIIAGYEATVSAFLQSTSWGECICGSGRVMHDESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAB7</accession>
    <name>A0A0G4PAB7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S009g000192</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PAB7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PAB7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL23252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="530" mass="59225" checksum="DD1AB20C6D0ED9AA" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAW7</accession>
    <name>A0A0G4PAW7_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Amine oxidase</fullName>
            <ecNumber evidence="11">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S009g000403</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="11">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="10">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10 11">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="11"/>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PAW7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PAW7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000011">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000017">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015802">
        <property type="entry name" value="Cu_amine_oxidase_N3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF92">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02728">
        <property type="entry name" value="Cu_amine_oxidN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="13">
        <location>
            <begin position="26"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase N3-terminal" evidence="14">
        <location>
            <begin position="125"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="12">
        <location>
            <begin position="258"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="413"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="10">
        <location>
            <position position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CRL23463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="688" mass="77897" checksum="F308A5843CBD4380" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBD7</accession>
    <name>A0A0G4PBD7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BRCT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S010g000022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PBD7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PBD7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035361">
        <property type="term" value="C:Cul8-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990683">
        <property type="term" value="P:DNA double-strand break attachment to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00027">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18436">
        <property type="entry name" value="BRCT_BRC1_like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18437">
        <property type="entry name" value="BRCT_BRC1_like_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17743">
        <property type="entry name" value="BRCT_BRC1_like_rpt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000066">
        <property type="entry name" value="BRCT domain protein (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000048">
        <property type="entry name" value="DNA repair protein Rtt107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053036">
        <property type="entry name" value="CellCycle_DNARepair_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667:SF1">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16770">
        <property type="entry name" value="RTT107_BRCT_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="6"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="104"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="239"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="341"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="612"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL23584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="851" mass="94923" checksum="D3877269BAD612EA" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBW3</accession>
    <name>A0A0G4PBW3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-nitropropane dioxygenase, NPD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S010g000241</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PBW3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PBW3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF36">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL23803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="348" mass="36084" checksum="DE8412CDCEE9DDBD" modified="2015-09-16" version="1">MSLQTPLCSLLKIQHPVLLAGMARASGAPLAAAVSNAGGLGTIGGLGYTPAQLSEMLTELKSLLRDPSLPFGVDLALPQVGGSARATNHDYTHGQLDELIEVTISHGAKLFVSAVGIPPAKTIKRLHEAGILIMNMVGAPKHAHKAFKAGVDIVCAQGGEGGGHTGEVPFSVLVPAIVDVAREYKSPLTGQPALVVAAGGINDGRSLAASLMFGAAGVWVGTRFVASEESGASRLHKEAVVGAQFGETKRTLVISGRPLRMLPNDYIKEWEARPADIAALTSKGVVPMVDDLENEKDVDVPFLMGDVSASVKEIKPAGIIVKEMVQQAVEVLKVGGSYINSTGPASKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBX7</accession>
    <name>A0A0G4PBX7_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S010g000212</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PBX7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PBX7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="30"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL23774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="434" mass="45968" checksum="B8632F2FAF5B313A" modified="2015-09-16" version="1">MSKIELIGFEGRPIRSLFINNEFQLATGGSQLEVENPTTGSVLASVSAAQRQDVDAAVSAAKSALQGPWLTVTPTRRGQLLNRLADLIERDADDLASLEALDAGVLFGESKGLHIPQATETLRYFAGWADKIAGQLFSIPQGYSYTRREPLGVCAAVKLAPAIAAGNALIIKTPELVPLYAQKLASLIKEAGFTPGVLAILCGSSSVAGQALAEHGGVKNIAFTGSAPVGREILRAVAGSNLKKMTLELGGKNPSIVFSDADLDNAIFWTTLGFTANNGQVCAAGSRIYVHANIYDKFLLAFAEKLAHITPGDPLSGKTTKGPVISHARIIQEEIFGPVASIAKFNTEAEVIEKANATEFGLSAAVFTNDVHRAQRVSEAMECGQVTVTCWGMLHANTPFGGVKQSGFGRDMGEEVLEAWMSTKNCQVLYSTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCD2</accession>
    <name>A0A0G4PCD2_PENC3</name>
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        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
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    </gene>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PCD2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL23968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="61" mass="7258" checksum="65C202A82FCE6C9C" modified="2015-09-16" version="1">MPQYHPIIEQVHSRLCIDTRYSQWPGKVFFLGKVHSQQATHIEQWFHNSEHLVNTTTVGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCI2</accession>
    <name>A0A0G4PCI2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S010g000417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793143">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PCI2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL23979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="405" mass="46111" checksum="F9A3FC883D9A2379" modified="2015-09-16" version="1">MARELLIMGHTQNLRDIESNNEKKHSHWRDWAFVLLWGVTGYACIIFIVLAYCNPGLIPFDISSLLFRKEISPFFAFSQGTGHYSKPQGFKIVALVPFHYHERTAILDCYLQVVFVPQTDDAASMEWLYSIVNQTPEYSISSRGHEMEWKVAKDNVMYIRIDGDIVFLEDSAISTIVKTKLDNPSTLMVSANVINEAALASLHSHPGTALPYLPELYDVKQPSRSKSQLKHDWRASSLPSWQGPPNFEVRKDFEPPFEGHRWLLPRDAGSGRDPIARSVYTDTGPTLHDWTVGAQQHYSFLHHLEHNDLGRYKFPMWVDPTEPTSENFGCFWGNDAVDVHNILRNQKGSSHNWHMADDSRPHVIIDGKGLVSHYSARQGAAGLDATDLLTRYRAYAQEKVCLQTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCS2</accession>
    <name>A0A0G4PCS2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sugar/inositol transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S011g000092</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
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        <property type="protein sequence ID" value="CRL24098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF23">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="28"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="512"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="519"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL24098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="544" mass="59160" checksum="BB11661EE4E20C33" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCT9</accession>
    <name>A0A0G4PCT9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S011g000063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PCT9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PCT9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL24069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="482" mass="54414" checksum="C9587F0C735E9A14" modified="2015-09-16" version="1">MMSAESPGQKNGFKSFLSNALRPKKSRQTLRKGSRSTTDLRLAARSSVEEAPPMPELAPLHAHKLKYRELHAQVDSQLGERRDYTEIIHTLGTLDVNDPSVAGYESNEHRPQGEGDIASLSPKLWAQIAGYLNPAEAASLAISTITLYRRLGPRYLMALDHPDNHTHKINFLSGLDISLPHHLLCFPCAQYHRRTQEGNERIRPSHVLNPLFNCRNSTNALKPPPRHRITHGRNLPFTFVQLAMRAHRFGPSYGLAPDALGRRWQRDNWSHTSRFHVHEGRLLMRVTSQTFAAPALTPSAQRMLLYSRDDYCPYFSACAHWRDGELMPACKCALEHIPRPRSSGGLQGLEHRVKDRIAGQVFDPNALTTLCGFCRPMRRCPECPTEYLIEVKLSEDLEDRRFKQAIVVTRWSDLGDGTTPGGIEWGAINGKRDDYDSFAHYAKRGIASIFEAAFTADTLPGQRVVSLNPKKKTLGEEGNRWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCV6</accession>
    <name>A0A0G4PCV6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BSD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S011g000073</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PCV6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PCV6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13229">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000406">
        <property type="entry name" value="Putative RNA polymerase II transcription factor related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027079">
        <property type="entry name" value="Tfb1/GTF2H1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013876">
        <property type="entry name" value="TFIIH_BTF_p62_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12856">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08567">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BSD" evidence="8">
        <location>
            <begin position="225"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="440"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="452"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL24079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="644" mass="71130" checksum="669D91E5D3D86A2F" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDA1</accession>
    <name>A0A0G4PDA1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S011g000256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PDA1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PDA1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="398"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL24262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="473" mass="51521" checksum="82342451113342F1" modified="2015-09-16" version="1">MAPFGQTIAVIDKSGKVVSTSKQLFGVFSHAKNAYRERKSAFQSERNAKIAEQQALQGLANYQIDDAPSVAPSRRSRGTRSRHHSGRSHRAASHYDDEQTVISRQDSHYEPPQTIARRHTHHDLSVRDAPRPSTARSRSDAHIDMDLAYGDASHAALSRYNPPEPKNDQQQLDGLVNKAQWLLEEAHCMQHGATATIAHLQKNPDAMAAVALTLAEISNLGSKMAPAALTTLKSAAPAVFALLSSPQFLIAAGVGLGVTVVMFGGYKIIQRIKAGAIGEEGKPAETEMEMEEMMELNTEDLSSVEMWRRGVADEQAYSVGTSVDGEFITPTAAAMSGIDVTTARARRDPRFKFEEDASVASSRRSRRSRTTRAPTHAPSHAPSERHERRSKAPSEAPSGFFGRSSSRSKAPSKAPSRAPSRAPSRSRAPSRAPSNAPSRAPSKHSTYISETEKRPKEKKKGPSRLRLMFTSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDB9</accession>
    <name>A0A0G4PDB9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S011g000248</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PDB9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PDB9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="72"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="76"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL24254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="255" mass="28901" checksum="B7C95243AC54DA19" modified="2015-09-16" version="1">MSINRAIKQLGGLMSKVARYRATLSNSRDAALSPGKMASLAEYITSGDSDEGLLDESSNDDIAEISEEETETRHACTSCTEEYPLSDIFQTECSHTYCRECILHLFENSLTNESLYPPRCCRQPIHASTAVEDMIGIEMTKRFKERKIEISASERTYCSKKTCSRYIPPHNIRRGVGICEFCTARTCTDCKKQGHRGDCNDENANKQSIAHDDEKARDEEANDALLEKLAKRKKWKRCPNCSRMIERVSGCDYIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDS0</accession>
    <name>A0A0G4PDS0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger, LIM-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S012g000028</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PDS0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PDS0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09391">
        <property type="entry name" value="LIM1_Lrg1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09392">
        <property type="entry name" value="LIM2_Lrg1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04397">
        <property type="entry name" value="RhoGAP_fLRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000033">
        <property type="entry name" value="Rho GTPase activator (Lrg11)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000112">
        <property type="entry name" value="Rho GTPase activator (Lrg11)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000058">
        <property type="entry name" value="Rho GTPase activator Lrg11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215:SF10">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="105"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="169"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="9">
        <location>
            <begin position="855"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="599"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="672"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="751"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1094"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="605"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1106"/>
            <end position="1121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL24419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1210" mass="133734" checksum="5CE107E718A0FCDF" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDV0</accession>
    <name>A0A0G4PDV0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Benzoate 4-monooxygenase bphA</fullName>
            <ecNumber evidence="12">1.14.14.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Benzoate-para-hydroxylase A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Cytochrome P450 monooxygenase cyp53A1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PCAMFM013_S012g000075</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>benzoate + reduced [NADPH--hemoprotein reductase] + O2 = 4-hydroxybenzoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18033"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16150"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.92"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.92" evidence="12"/>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PDV0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PDV0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018664">
        <property type="term" value="F:benzoate 4-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000053">
        <property type="entry name" value="Cytochrome P450 benzoate 4-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF29">
        <property type="entry name" value="BENZOATE-PARA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 16 17" id="KW-0349">Heme</keyword>
    <keyword evidence="7 16 17" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 17" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="16">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00082391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CRL24466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="512" mass="57549" checksum="0E541DD39CD912C8" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PEA3</accession>
    <name>A0A0G4PEA3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Six-hairpin glycosidase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S012g000253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PEA3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PEA3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987:SF2">
        <property type="entry name" value="B, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987">
        <property type="entry name" value="C, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-rhamnosidase six-hairpin glycosidase" evidence="1">
        <location>
            <begin position="381"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL24643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="813" mass="91828" checksum="542F812CB87FAD84" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PED5</accession>
    <name>A0A0G4PED5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">fumarate reductase (NADH)</fullName>
            <ecNumber evidence="7">1.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NADH-dependent fumarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S012g000315</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>succinate + NAD(+) = fumarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18281"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.6" evidence="7"/>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PED5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PED5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016156">
        <property type="term" value="F:fumarate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000007">
        <property type="entry name" value="NADH-dependent fumarate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF1">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="9">
        <location>
            <begin position="538"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00067004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL24705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="622" mass="66814" checksum="3422E2F102E93307" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PEN3</accession>
    <name>A0A0G4PEN3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S013g000033</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL24791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PEN3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PEN3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF1">
        <property type="entry name" value="NADP-DEPENDENT MANNITOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL24791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="276" mass="29940" checksum="EDAE54406F6DEE4B" modified="2015-09-16" version="1">MSMSIEDCAQNREGFPRPFPDTPSNVLEQFKINGKVVVVTGAADGLGHAIAQSMAEAGAHVALWYNSNDVAIEKAQVLAKEHGIKAFAYKVDVSESIQVSQTMTKVVTDFGKIDVFIANAGMAISKPILEQTLEEYRKQMSVNVDGIVYCAKYAGEVFARQGHGNLIITSSMSAHIVNVPTDQPVYNATKAYVTHFGKSLAREWRDFARVNIVSPGFFDTKMGAGPSALQEAYRMSSLGRQGHVKEIKGLYLYLASDASSFMTGSDVLIDGGYVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PEV5</accession>
    <name>A0A0G4PEV5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COX assembly mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S013g000097</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CMC family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL24854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PEV5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PEV5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013892">
        <property type="entry name" value="Cyt_c_biogenesis_Cmc1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977:SF5">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08583">
        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="101"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL24854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="141" mass="16255" checksum="47ADA82B9C39600D" modified="2015-09-16" version="1">MATSSTSPDTSSTSVPKSAPKQYNLRNPLPLSAPQEQEVKLLYYKRVRAHCAPEIKAFAECAVNRTVTATWICRQQRLAMNSCMVAHAKPEEEDRAREEWFAGYEERRRAKEEDLARVEKRREEVIRMMREDEARARAAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PFB2</accession>
    <name>A0A0G4PFB2_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Self-sufficient cytochrome P450 monooxygenase CYP505E4</fullName>
            <ecNumber evidence="5">1.14.14.1</ecNumber>
            <ecNumber evidence="17">1.6.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">Bifunctional cytochrome P450/NADPH--P450 reductase CYP505E4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">PCAMFM013_S013g000235</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17149"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:142491"/>
            <dbReference type="EC" id="1.14.14.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>dodecan-1-ol + reduced [NADPH--hemoprotein reductase] + O2 = 1,4-dodecanediol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:76763"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:28878"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:195422"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:76764"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>dodecan-1-ol + reduced [NADPH--hemoprotein reductase] + O2 = 1,5-dodecanediol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:76759"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:28878"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:195414"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:76760"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>dodecan-1-ol + reduced [NADPH--hemoprotein reductase] + O2 = 1,6-dodecanediol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:76779"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:28878"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:195445"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:76780"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>dodecanoate + reduced [NADPH--hemoprotein reductase] + O2 = 5-hydroxydodecanoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:76723"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:18262"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:195418"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:76724"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 26">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="27">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="5"/>
    <dbReference type="EC" id="1.6.2.4" evidence="17"/>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL24992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PFB2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PFB2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000040">
        <property type="entry name" value="Bifunctional cytochrome P450/NADPH--P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24303:SF31">
        <property type="entry name" value="CYTOCHROME P450 307A1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24303">
        <property type="entry name" value="HEME-BINDING MONOOXYGENASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0288">FMN</keyword>
    <keyword evidence="7 26 27" id="KW-0349">Heme</keyword>
    <keyword evidence="15 26 27" id="KW-0408">Iron</keyword>
    <keyword evidence="10 26 27" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16 27" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="12" id="KW-0521">NADP</keyword>
    <keyword evidence="14 27" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="binding site" description="axial binding residue" evidence="26">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00050670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00050725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00051516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00052652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00069187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00081991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="CRL24992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="455" mass="50920" checksum="BE09EE0F9B33C068" modified="2015-09-16" version="1">MPTKIPGPPGVPLLGNIFDVDPNETWNSLNKLAKQFGSIFKINALGHEIVFIGSVALLEEICDQTRFRKCVTGPVVEIRYAVHDSLFTAYDYEKSWGIAHRIMMPHLTQSATDNLFGDMAEVIPDLTKKWSAGTKTRTLLTNDLDRLLLASCMQCFFNQRVHVLGGAEPPMLAAMNGATMEAMKRPTRPKLLNWLYQRRFEKDTKTMRGFAAQVIKTRKEQPETARKDILDAMLNGADPESGEKLTESQVIDEIISIFIGAATAPNLVSYALYYLLENPSEITKAQEEIDRVVGDGKIDLEHLQSLNYVEAILRESIRLSATAPGFNIEPIPSDDKSPVLLAGGEYQIAHNQPMIAVLSQVNRDPAVFEDPEAFKPERVLGEKWDQLPAAAKKGFGNGKRECIGKLWAWRWSFFTLASIIKENTFELADPKYKLESNGAFSIKPLEFYGLVSPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PFN9</accession>
    <name>A0A0G4PFN9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 15">Aurora kinase</fullName>
            <ecNumber evidence="1 15">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PCAMFM013_S014g000022</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1 15"/>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PFN9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PFN9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045143">
        <property type="term" value="P:homologous chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044779">
        <property type="term" value="P:meiotic spindle checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090266">
        <property type="term" value="P:regulation of mitotic cell cycle spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902115">
        <property type="term" value="P:regulation of organelle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072479">
        <property type="term" value="P:response to mitotic cell cycle spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14007">
        <property type="entry name" value="STKc_Aurora"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000235">
        <property type="entry name" value="Serine/threonine-protein kinase ark1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="112"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="66"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 13">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="190"/>
            <end position="192"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="239"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="12">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CRL25126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="388" mass="43953" checksum="E07429C6C6BD0ACA" modified="2015-09-16" version="1">MATTKTLEARFEHLSMKDEKENGNSDRTYGKQKAPVSSAQSNSNSNRAQLLKLALQNNNENKANAMNVPASPGRGSHGALVTRSTDENGDQRTSSSLCEQPTVPKDLHLGMFEIGKPLGKGKFGRVYLAKERSSGFVCALKVLHKSELQQGGVQKQVRREIEIQSNLRHPNVLRLYGHFHDSKRIFLILEFAGRGELYKHLRKEHRFPEWKAAQYIAQMAAALKYLHKKHVMHRDIKPENILVGIHGEIKISDFGWSVHAPNNRRQTMCGTLDYLPPEMLAHGSKDNYYSEKVDLWSLGVLMYEFLVGEAPFEDTPVMTQRRITRADMSVPSFVSPEAKDLIKKLLVLDPAKRIPLEEIQRHPWIVKHCEKDDRTVKRSSGSSKEGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGG8</accession>
    <name>A0A0G4PGG8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S014g000236</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PGG8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PGG8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195322" evidence="3">
        <location>
            <begin position="24"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL25340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="120" mass="13190" checksum="06586DE082590616" modified="2015-09-16" version="1">MNVQVNHIGTALLSLLLLSPLQSSQPTRLTIVTSEVHFWTEFEAKDAPNILARLDEPSSFGKGMDRYNTSKLLNILWLRELSSKVGPNLIVNGVNPGLCASTLHRSDTTPGINTFNKVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGR5</accession>
    <name>A0A0G4PGR5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription factor Opi1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S015g000127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793148">
        <property type="protein sequence ID" value="CRL25541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PGR5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PGR5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013927">
        <property type="entry name" value="TF_Opi1_Ccg-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR OPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38406:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR OPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08618">
        <property type="entry name" value="Opi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL25541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="490" mass="52941" checksum="849857904A2E8A58" modified="2015-09-16" version="1">MEPPKTARPKPPIRKINATSLSSTNSLPSALTSNLAPSLTTPPYHNAHPSVMDVDKAEDRSRRAASVLSMDDLEAAQALEGLRSDFGQSPRTAQQSLPVTSPDPPQPEPLLSLLTSSHPLISSAINGSVSAYATSKSYSPRFKSGAEFIERNIGSPVANTVGTVGRKTGVESGLRWALQRRDSTSEDSKHVSKRRKMDGDVSPRTINGEKGPHGSAHPPRTRSSSDLSMDESLPPYDEVRSPHYEEKPGRRAEPTWQSRLVISTSGLGVAMSDESLRSLQYCLTWLRWANGRLGKSIVALHSAVNEWENHKARSPSDMEAGDNGQESASLLIQRIQAVKADVLSTLKQVVDVVSKYAGGALPENARHLVRRHLTSLPHRFQVASTSQPPPDSPAAASDATISAHRILVLAQEGLDMMAQVSGVVNDTLVSAEHWCERLGRKRPENGASSDVPEKQGESASDAQPYGMDIKQSLPENSIQDDVSMSGMEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGS8</accession>
    <name>A0A0G4PGS8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phytanoyl-CoA dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S015g000165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793148">
        <property type="protein sequence ID" value="CRL25579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PGS8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630:SF6">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL25579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="318" mass="35885" checksum="A1002F37DBCC79F4" modified="2015-09-16" version="1">MYSAGAKTGDWLAELRDNGFAVIKNAIPQDRAIAYQQKAREWLKSFGNDELDYENPETWLAKNLPVQSTINTFSAYAVAHEKFMWDARIEAGVIEAFSKIWGTEELLVSFDSLNVTFPNRKDVPRKGAWEHVDQSPFRRGMHCVQGIINLSTAGPDDGGLVVYPGSHLLVDEFFDTQADPSTWSTKDLYWLDQTKLDWFKARGCSPHKVCADIGDLIVWDSRTIHYGSEPAETSQTIRTVIYAAYSPAKFASTETLQCKSEVFSKYGGTTHWPHDNVVVRKTCAMLPDGTRDPRDREEPLEPPQMSDRLLKLAGVKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PI73</accession>
    <name>A0A0G4PI73_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S017g000012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793150">
        <property type="protein sequence ID" value="CRL26029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PI73"/>
    <dbReference type="STRING" id="1429867.A0A0G4PI73"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL26029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="90" mass="10166" checksum="228580C4FEE4967A" modified="2015-09-16" version="1">MPTEDNNSRYIKLSAAKSTTAKSRLPPAIVRASSIPAFMTLWWMPFPLIMYHYGAVVRMKCKYSFEAAEMIKKMQMQQTAATADNDKEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PI92</accession>
    <name>A0A0G4PI92_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Large ribosomal subunit protein mL67</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S017g000123</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL67 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793150">
        <property type="protein sequence ID" value="CRL26140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PI92"/>
    <dbReference type="STRING" id="1429867.A0A0G4PI92"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024629">
        <property type="entry name" value="Ribosomal_mL67"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28184:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28184">
        <property type="entry name" value="MITOCHONDRIAL HOMOLOGOUS RECOMBINATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12829">
        <property type="entry name" value="Mhr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL26140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="332" mass="38185" checksum="0288E39139452DBD" modified="2015-09-16" version="1">MASNTKSFQKVLDSTALAATKFIRRPPIDPKTPIQGKPRVPGSNAFKEHQDKEGRRLQKALNSITHGKNIFVYNNIRTKQVVYSLTRYLEKTNLLKQCVNHGKKTIPATVRKDMWVPYFSVHFNEAQVGLNVYNHLRQFALLRQLSPPKEMITVTKEYLDSKRPVDLRDQKQWDKENMGRLGQIMMKKERAYALMNQKATAIADIAFVLQKHRDHIVEGVPESSKSGYKTLKARRRRRAALLQEAEQAKARAGEVASLEEQLEVEISTDHSAPQEQTVKILWQDTYDAQFAKNWPDYIEHGQLRWTRNHLIGQEDLPVPSEDIIADGSFEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PIJ8</accession>
    <name>A0A0G4PIJ8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S016g000277</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793149">
        <property type="protein sequence ID" value="CRL25996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PIJ8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL25996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="206" mass="23434" checksum="94E4C536DB8D395B" modified="2015-09-16" version="1">MTATTDTQALADLLEPCSFNWDDDAEEAFGTLKSVTQPSTHHITIHPVTRAIAEADGNDIMEIFSLQNIAVFNPPLPAIEEEYTPAQTYSDYSLKNSFGRADNSERVFHVHHTAYPITLAIARAIYGASEDDIMAVFRYQRIPLFEPSLPAIEEGYHTLSALIRSHLIYVITIISIMARAFRYRHGWKQNTYYLRRFVYCSMIGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJL9</accession>
    <name>A0A0G4PJL9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]</fullName>
            <ecNumber evidence="3">1.3.1.124</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S018g000036</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a (2E,4E)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:45912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85101"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (2E,4Z)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61892"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85099"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.3.1.124" evidence="3"/>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJL9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJL9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05369">
        <property type="entry name" value="TER_DECR_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045017">
        <property type="entry name" value="DECR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296:SF2">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE [(3E)-ENOYL-COA-PRODUCING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL26343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="316" mass="33339" checksum="EFD0A51AF0406B89" modified="2015-09-16" version="1">MPLPKTEYLSDSWKDGIFANKVVFCTGGAGTICSAQVRALVHLGANACIIGRNVEKTERVAQDIATARPGAKVIGIGSVDVRQLESLQKAVERCVKELGGIDFVIAGAAGNFLASIEQLSVNAFKSVMDIDVLGSYNTLKATLPYLRESASKHRIDSKTLQPSPIGTGGRIIFVSATIHYRGMPFQTHVSVAKAGIDSLSNSVAIEYGPRGMTSNIIAPGPIASTEGLERLLPSDAMEAYTKAQPLGRFGHVRDIADATVYLFSDTGSYVSGQTLVVDGANWRMSAGGASGGNLSYPDFLLSGDDVPNVTGKKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJN5</accession>
    <name>A0A0G4PJN5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ubiquitin-conjugating enzyme E2 1</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">E2 ubiquitin-conjugating enzyme 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme E2 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S018g000069</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="13">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJN5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJN5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23800">
        <property type="entry name" value="UBCc_UBE2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000037">
        <property type="entry name" value="ubiquitin-conjugating enzyme E2 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015368">
        <property type="entry name" value="UBA_C_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09288">
        <property type="entry name" value="UBA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="14">
        <location>
            <begin position="4"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="12">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CRL26376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="237" mass="25814" checksum="6E72D2144A74ED71" modified="2015-09-16" version="1">MASNRMRRIGKEIADIHADAHSQIKVEPFGNQDDVTHLRGSFPGPPGTPYEGGTYNIDIKIPTDYPFRPPTMKFETKVWHPNVSSQTGAICLDTLSSAWSPVLTIKSALLSLQSLLSTPEPKDPQDAEVANMLLKSPKEFERVARDWAVTYAGAPAGNADNGSGSSLDDTRQGAGEDSLAKYDGYNKNLIDRFTSMGFDVDRVVAAFRYVGADRRGGQDYELEEGSMGDIAARLLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-11-27" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJQ5</accession>
    <name>A0A0G4PJQ5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S019g000074</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Vacuole membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ATG22 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJQ5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJQ5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF5">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 9" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="439"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL26657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="530" mass="59456" checksum="9D08C94C83215F66" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJS5</accession>
    <name>A0A0G4PJS5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitinase</fullName>
            <ecNumber evidence="2">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S019g000094</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="2"/>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4PJS5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018371">
        <property type="entry name" value="Chitin-binding_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053214">
        <property type="entry name" value="LysM12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700:SF2">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700">
        <property type="entry name" value="V CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00026">
        <property type="entry name" value="CHIT_BIND_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195408" description="chitinase" evidence="6">
        <location>
            <begin position="23"/>
            <end position="1718"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="7">
        <location>
            <begin position="42"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="7">
        <location>
            <begin position="88"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="8">
        <location>
            <begin position="145"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="81"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="127"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL26677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1718" mass="189391" checksum="972F1544C7112CC9" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKH9</accession>
    <name>A0A0G4PKH9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S020g000003</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793153">
        <property type="protein sequence ID" value="CRL26844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKH9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="197"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="3">
        <location>
            <begin position="470"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="699"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL26844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="770" mass="86827" checksum="1ED158B3578CB622" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKV1</accession>
    <name>A0A0G4PKV1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA sliding clamp PCNA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PCAMFM013_S020g000191</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Involved in DNA repair.</text>
    </comment>
    <comment type="function">
        <text evidence="11">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processivity during elongation of the leading strand.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the PCNA family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793153">
        <property type="protein sequence ID" value="CRL27032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKV1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PKV1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043626">
        <property type="term" value="C:PCNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017022">
        <property type="term" value="F:myosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.150.10:FF:000006">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.150.10:FF:000008">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.70.10.10:FF:000001">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.150.10">
        <property type="entry name" value="DNA Polymerase III, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026859">
        <property type="entry name" value="Myosin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022659">
        <property type="entry name" value="Pr_cel_nuc_antig_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00590">
        <property type="entry name" value="pcna"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12632">
        <property type="entry name" value="Vezatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01251">
        <property type="entry name" value="PCNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00293">
        <property type="entry name" value="PCNA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin-binding" evidence="17">
        <location>
            <begin position="152"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA N-terminal" evidence="15">
        <location>
            <begin position="657"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA C-terminal" evidence="16">
        <location>
            <begin position="784"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="502"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CRL27032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="914" mass="101257" checksum="5E75C4125E604721" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKY4</accession>
    <name>A0A0G4PKY4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S020g000244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793153">
        <property type="protein sequence ID" value="CRL27085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKY4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL27085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="55" mass="6185" checksum="D261880638947B37" modified="2015-09-16" version="1">MASLSFNYLDSDLDSDPKVIPKSLPALLSTLLSPEIGTELINLLKERRREREALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PL88</accession>
    <name>A0A0G4PL88_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S021g000049</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793154">
        <property type="protein sequence ID" value="CRL27134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PL88"/>
    <dbReference type="STRING" id="1429867.A0A0G4PL88"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF103">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL27134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="502" mass="55975" checksum="144B31B17A29CA72" modified="2015-09-16" version="1">MLEVSLPAFSVLGPVQTTGLVIGLVLTGYISFMLYFHPLSQYPGPKIASLTSLWRAYYVYKLVLHEKLVELHQKYGPVVRIGPNHLHFWDGEAIAPIYKAGRKMGKTEFYGAFTAFNPNLFGGRDEDIHSLRRGQLAHGFSQASVENFEPLINGHIEILLSKLNKFAKTGEVFDLKSTISYFVLDILGEVAFSRPFNAQVRGEAGEIHAINDHLLLSCVIGELPFQALSKFLARWSPIPWMRKLGKSRNNLKAICSECVSNKINNASDRRDLLQSLVTAKDVETGARLTEQEINSEAFAMLVAGSHSTSGTLTLLFWHLIHNPEICATVATEVASTLQPLQDGDISYPIKGLEPSLPYTMACVRENFRLNPVFTMPLWRSVGSPGGARIGEFDVPCGTNVCISNYVLHHNPTIWGEDHAVFQPDRWLGKDEPNRSRFIIPFSIGHRMCIGRNLAMTNMLKTITTLISQFDFHPISQDDHVRVRSSGIGEMEGSFQCKVSVKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PLD1</accession>
    <name>A0A0G4PLD1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S021g000152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793154">
        <property type="protein sequence ID" value="CRL27237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PLD1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PLD1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF3">
        <property type="entry name" value="HALOACID DEHALOGENASE, TYPE II (AFU_ORTHOLOGUE AFUA_2G07750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL27237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="169" mass="18211" checksum="9EAA53FBF1F2A810" modified="2015-09-16" version="1">MQAYDSLSTFSDVNPALAHIAADPTIQAVIFSNGAKPTVSNSVLRSKDLSPHASVFQDIVTVDEFQQFKPSKTCYEHLAKQTGQDPSQMSKLWLISGNPFDIVGARATGMQALWVDRIGAGWKDAVAPDLQPTGIVQSGADYERNSLPSALSQGFHGILNKGSKHQKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PLZ3</accession>
    <name>A0A0G4PLZ3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proteasome component (PCI) domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S021g000121</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S9 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793154">
        <property type="protein sequence ID" value="CRL27206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PLZ3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PLZ3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000010">
        <property type="entry name" value="26S proteasome regulatory subunit RPN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040780">
        <property type="entry name" value="Rpn6_C_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040773">
        <property type="entry name" value="Rpn6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18503">
        <property type="entry name" value="RPN6_C_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18055">
        <property type="entry name" value="RPN6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="222"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL27206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="422" mass="47359" checksum="B85A011CEFB8989D" modified="2015-09-16" version="1">MSSKVSPRIQEVRDLVKEDPSKAATSYQNILSEGPGSTEASSRDYELALIGLGELHRDAKKPQEIADLIKTSRDTFSSFAKAKTAKLVRQLLDLISEIPNTLELQGSVIQSCIEWAIAERRSFLRQALQARLVAIYMQKQSYYDALTLINSLLRELKRLDDKLMLVEVQLLESRVYHALGNQAKARAALTAARTSAASVYTPPNLQAGLDMQSGMLHAEDKDFTTAYSYFIEALEGYSSLDESDLATATLQYMLLCKIMLNLVDDVTQLQGSKQAQKYASPRLEAMKAVARAHANRSLEEYEKALSDYRYELGSDIFIRNHLRRLYDAMLEQNLIKVIEPFSRVELDHIAKMVGLDTQQVERKLSQMILDKVIIGVLDQGSGCLIVYDETERDQAYDAALETIEKLGNVVEGLYTNQASLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PM60</accession>
    <name>A0A0G4PM60_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S022g000185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793155">
        <property type="protein sequence ID" value="CRL27505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PM60"/>
    <dbReference type="STRING" id="1429867.A0A0G4PM60"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL27505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="80" mass="8631" checksum="7046996C2DC40F61" modified="2015-09-16" version="1">MLQNYGSEYTGSKLTSHDLKFHNWPGAGEQAADHFGLSHVVIIPANPCRILIGGQLGIRDDGSIPTDPVEEADIAFEHAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PM74</accession>
    <name>A0A0G4PM74_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S022g000202</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793155">
        <property type="protein sequence ID" value="CRL27522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PM74"/>
    <dbReference type="STRING" id="1429867.A0A0G4PM74"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL27522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="166" mass="18754" checksum="45636A2905B341E3" modified="2015-09-16" version="1">MKATESEQQRFNEQNYSHLSPKNTQTAIWTILSQRNVEFNIIITATPMFNSIDDLACLVGLLGSRGVARLKSKLCSDPHLKRGSSCLDKTHLSKIKENFEDVPTTSPLRLNLPKSSTLRKITKEEVFGVYAAVPVYFALVFDTVAIQRTQASFLKKLKRCHDPIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PM78</accession>
    <name>A0A0G4PM78_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldolase-type TIM barrel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S022g000207</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793155">
        <property type="protein sequence ID" value="CRL27527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PM78"/>
    <dbReference type="STRING" id="1429867.A0A0G4PM78"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000059">
        <property type="entry name" value="N-ethylmaleimide reductase, FMN-linked"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF129">
        <property type="entry name" value="FLAVIN OXIDOREDUCTASE HXNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="4">
        <location>
            <begin position="10"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL27527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="385" mass="41916" checksum="92B8B5F4EFDAEDA1" modified="2015-09-16" version="1">MGSIAITDPLFESVRLGALTLKHRVVLAPLTRMRAGKESDGVYVPNELNVEYYSQRASEGGFMLTEATPISRHAAGYPGVPGIFTSSQIAGWKKVTDAVHAKGGYIYCQLWHVGRATVSSFIEGKEVVGASEIPISGNALDGSEYAASPPRAMTIEEIQDTVKEYVGAAKRAREAGFDGVEVHGANGYLLDQFLHDNVNTRTDEYGGSIEKRSRIILEVLKAVSAQIGADRVGIRLSPYNYFQDTRDSNPNANWLALCSLIARLPEDSRPAYVHMVEPRFDEVMDEAAKIDSLASDKPSLDVFRPTLKKSGISLLAAGSFNAENAGSKLAAGGADAVVFGRYFISNPDLPRRLKEGLPLTPYDRTTFYGAEPAEKGYTDYPFYTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PN73</accession>
    <name>A0A0G4PN73_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Indoleamine 2,3-dioxygenase</fullName>
            <ecNumber evidence="5">1.13.11.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S024g000112</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Produces N-formyl-kynurenine through the oxidation of tryptophan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-tryptophan + O2 = N-formyl-L-kynurenine</text>
            <dbReference type="Rhea" id="RHEA:24536"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.52" evidence="5"/>
    <dbReference type="EMBL" id="HG793157">
        <property type="protein sequence ID" value="CRL27857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PN73"/>
    <dbReference type="STRING" id="1429867.A0A0G4PN73"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF10">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00876">
        <property type="entry name" value="IDO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL27857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="424" mass="47101" checksum="55843B7CF8BABC4C" modified="2015-09-16" version="1">MLQSTDAVFNGLFEDYAEQGFLPDALPLARISNAYYETWESIASQLPNLIQTNQIREKIDNMPVCTTEHLQTEPEWRRACVIMGYLAHAYIWGGETPKDRLPPSISKPFLEISAHLELPACATYAGLTLWNFIPSHPEADITDPDNLHVQTSFTGTKDEEWFMVISVAVEAKGIKLISLMRDAFKAVTANDVDLLTALLCRFADGLCDLTLTLKRMYEHNQPAVFFHQLRPFLAGSKNMGHAGLPNGVYYDVGDSDGVERPENWLQLSGGSNAQSSLIQALDIFLGIKHSATDGKQTCGPSFIQQMRDYMPGPHRRFLEELSDRANVRSFILDSPVQPLKDAYNAAVNELKAFRDTHIQMVTRYIIMASRQPNPVAQGKGKMNLATASSQMKEAGAKTKLAGTGGTDLIPFLKKTRDTVQDAKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-11-27" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNL7</accession>
    <name>A0A0G4PNL7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">dTDP-4-dehydrorhamnose reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S025g000085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793158">
        <property type="protein sequence ID" value="CRL28027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PNL7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PNL7"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048269">
        <property type="term" value="C:methionine adenosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048270">
        <property type="term" value="F:methionine adenosyltransferase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05254">
        <property type="entry name" value="dTDP_HR_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000357">
        <property type="entry name" value="Methionine adenosyltransferase 2 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="DTDP-4-DEHYDRORHAMNOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491:SF4">
        <property type="entry name" value="METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD-like substrate binding" evidence="1">
        <location>
            <begin position="4"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL28027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="321" mass="35531" checksum="744B3CC26D5962AA" modified="2015-09-16" version="1">MTSTVLVTGASGFLGRAVFNTFQHSGVLVVGQGFSRPAPPTILKADLEKEEDIRMLFDEVKPQIVIHCAANKSPDLCDKNPDQARKVNVDATRTLATECQARGAFLIYISTDYVFPGTEGDAPYEADSETKPPNLYGQLKGDGEVAVLEATKESGMGIVLRVPVLYGNAKENSESAVNTLVDAVKKATDENAGVKMDDWAIRYPTNTEDVARVCRDIVIKYLREKEKRKDFPRILQFSSEDRMTKYEICQKLAEVLGVAIPGMIPNKQGNDPNGGVVRPYDTHLSTKGLTELGIDVRTVDFIAWWSVLTTRRRRELGAYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNP3</accession>
    <name>A0A0G4PNP3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipopolysaccharide-modifying protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S025g000130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793158">
        <property type="protein sequence ID" value="CRL28072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PNP3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF107">
        <property type="entry name" value="GLYCOSYL TRANSFERASE CAP10 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="2">
        <location>
            <begin position="187"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL28072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="464" mass="53485" checksum="7FB5A370DFB4B94A" modified="2015-09-16" version="1">MTASFPIRPRRGLSLLCVITAFSFSAIIVIWFGMNSDREYIHPVLTQLIPAGHCACESSTTFQCSTCLTCPEPGLQADTTRTWSFEYTRDGRNEALGNSQCKSAFPGLFEDVARGVKFWSSHDRLSSVELDAIPIQHGMARAFISNGQLYVVTARSKGEDHRRKILGTLSSIHRALAADPERVSRRDFEFVFSVEDKVEDVTNSEWPVWVFSRTSTEEGVWLMPDFSFWAWDNRDNYMGPYDQVVERIERMDIPWSEKTPQLVWRGKPSFAPKLRRALMEAARDKSWGDVKQVDWNTGSNVLRMEDHCHYMFIAHVEGRSYSASLKYRQACNSVIVAHKLQFIQHHHYLLVAEGPNQNYVEVERDFSDLPDKMEPLVSNTKVAQRIANNSVKTFRERYLTPAAEACYWRSLFDGYADVWNGTVEQWSEAKDRERGLRYESFVLLESVKMYEFEATRTAQWQAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQF3</accession>
    <name>A0A0G4PQF3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SET domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S029g000040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793162">
        <property type="protein sequence ID" value="CRL28624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQF3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PQF3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="297"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL28624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="437" mass="49868" checksum="548DE0FA0B00B10E" modified="2015-09-16" version="1">MAPTRNKASKTTNKKTTNMKVNKRIAKAPLPPVDLDKLFPPWGSEEALNQTANKEATDITLAVYHDINAYCELERLAGEKVYGCPETFSNLRAFTERFVEREITDYMSCVESFKAEHGEFQPVTPNSRFLEFVTALGWKMFAICSHAESFRRGIKEADDRAWGCLLQKIHENFLSIELYAHNRTLKWRNILWIHQNYPIPGLPDMKPEIETYMNWKVDHPHHTVITLDGKLKEPTYNGQLQKHINESIYDPKKWNGRKQDPTLRQKPNGTPTNVGHKCVLCGSPVSCSCRLETRAGELVELREYPGTGTGARSLTRFRRGDILDIFMGELLPDIVEKVYPLTQNDDKLDTTTATVHNLCTICPHQLGNWTRFISHSCRPSTQFMTRTIGNRVVCTVEAIRDILPFEEITVGYGHRYWKALDYDCLCGYCDGSGSCLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQH3</accession>
    <name>A0A0G4PQH3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S030g000004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793163">
        <property type="protein sequence ID" value="CRL28717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQH3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PQH3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02024">
        <property type="entry name" value="NRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL28717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="332" mass="36309" checksum="8C4323922CD79AC7" modified="2015-09-16" version="1">MSKPVQEKAVIIGISGPSSSGKTTLARLLQRVFCGVNLKPEDSPLNTFIIHEDDFYFPDDKIPYTTTASGEKIQDWDTASAIDIPFLSQALHYVRENGTLPPRLRSKEDQNDATDSGVSDEIVQELRDIVGSRLRNAAAVKGTESPTIAFLEGFLLFAPPEQEQHVLRSVHDAIHLPLFLPAAYELVKARREGRSGYVTVGPAPEPPVQNTEGGEDGGDGKTGTDIDLEAEDDRPPQNFWVDPPGYVDDVVWPRYVTDHAWLLIAEDGDGDQKDGSQALAEAELVRRIGDGTRARTDVGVEVAPGCGSAGMDVVLRWAVELILGYYLDRMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQY1</accession>
    <name>A0A0G4PQY1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glucanase</fullName>
            <ecNumber evidence="11">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S028g000131</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.</text>
            <dbReference type="EC" id="3.2.1.91"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="11"/>
    <dbReference type="EMBL" id="HG793161">
        <property type="protein sequence ID" value="CRL28578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQY1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PQY1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016162">
        <property type="term" value="F:cellulose 1,4-beta-cellobiosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07999">
        <property type="entry name" value="GH7_CBH_EG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.100.10:FF:000001">
        <property type="entry name" value="Glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="entry name" value="Glycoside hydrolase, family 7, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001722">
        <property type="entry name" value="Glyco_hydro_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037019">
        <property type="entry name" value="Glyco_hydro_7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753:SF2">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
        <property type="entry name" value="Glyco_hydro_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00734">
        <property type="entry name" value="GLHYDRLASE7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 11" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195768" description="Glucanase" evidence="13">
        <location>
            <begin position="26"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="14">
        <location>
            <begin position="494"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="461"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CRL28578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="530" mass="55992" checksum="27508C7C82E9A1A6" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PR38</accession>
    <name>A0A0G4PR38_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Co-chaperone Hsc20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S031g000033</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HscB family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793164">
        <property type="protein sequence ID" value="CRL28865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PR38"/>
    <dbReference type="STRING" id="1429867.A0A0G4PR38"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.20:FF:000006">
        <property type="entry name" value="DnaJ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.20">
        <property type="entry name" value="HscB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004640">
        <property type="entry name" value="HscB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036386">
        <property type="entry name" value="HscB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009073">
        <property type="entry name" value="HscB_oligo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00714">
        <property type="entry name" value="hscB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021:SF15">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07743">
        <property type="entry name" value="HSCB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47144">
        <property type="entry name" value="HSC20 (HSCB), C-terminal oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="4">
        <location>
            <begin position="92"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL28865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="278" mass="30936" checksum="2D9BC2BE8FA76E54" modified="2015-09-16" version="1">MAFRPQRIAQHLCRTATPRPLSRPTNSLSNTSQDACMLCRYRQPARGLTTLPTRGSPITQTPMIQRRAASTETSTPTEPSKPTLAGAPDITNHYTIFPRTLPAGPPPGSTFAISTSDLRREFLQLQGLVHPDKYPNGAEKQLAEGLSARINEAYRTLLDPLQRAQYILREWHGIDVTAEDASAKHALDAETLMEVMEVQETIEEVGASADAEAQINALKKENEGRVVECVERLGEAFEKGDLEAARKECIRLRFWYSVGEGLREWEPGNTEIRLMHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PR55</accession>
    <name>A0A0G4PR55_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S031g000062</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HG793164">
        <property type="protein sequence ID" value="CRL28894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PR55"/>
    <dbReference type="STRING" id="1429867.A0A0G4PR55"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF98">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="159"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="614"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="664"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="513"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="513"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL28894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="855" mass="95666" checksum="BFADB02FA2F6F370" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRU6</accession>
    <name>A0A0G4PRU6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S033g000089</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>adenosine(1779)/adenosine(1780) in 18S rRNA + 4 S-adenosyl-L-methionine = N(6)-dimethyladenosine(1779)/N(6)-dimethyladenosine(1780) in 18S rRNA + 4 S-adenosyl-L-homocysteine + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42780"/>
            <dbReference type="Rhea" id="RHEA-COMP:10234"/>
            <dbReference type="Rhea" id="RHEA-COMP:10236"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.183"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8 9 10">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="HG793166">
        <property type="protein sequence ID" value="CRL29169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PRU6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PRU6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052909">
        <property type="term" value="F:18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000007">
        <property type="entry name" value="rRNA adenine N(6)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF7">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 9 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 9 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA adenine methylase transferase N-terminal" evidence="11">
        <location>
            <begin position="47"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL29169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="386" mass="43368" checksum="89B38AC61DD41219" modified="2015-09-16" version="1">MPKVNKPKRNSAASQGLSDAAAKTKAAHSIFKMNTDIGQHVLKNPGIAAAIVEKAELKQSDIVLEIGPGTGNLTAKILEKAKKCIAVELDPRMAAEVTKRFQSTPYQKRLEVILGDVMKTELPYFDVCISNTPYQISSPLTFKLLATSPAPRSCVLMFQREFALRLFAKPGDKLYSRLSVNAQMWAKIDHIMKVGKNNFKPPPQVESSVIRMVPKNPRPQINYEEWDGLLRIVFVRKNKTLRSSFIGTTSIMELLEANYRTWCAQHDIPVEDGPVEVANDDAMAIDMGEEQEEEEAVEEPADEVMEMDDDDVPDFFKESTNARLEAALKSGASRKKRGKVAELVREKVRQVLEDDTGLGDRRARMCDENDFLKLLWAFNQKGIHFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PS73</accession>
    <name>A0A0G4PS73_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S031g000119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793164">
        <property type="protein sequence ID" value="CRL28951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PS73"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL28951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="68" mass="8101" checksum="9247C21F61C3E69F" modified="2015-09-16" version="1">MERHSQWIGENFDAYDEKLFSSNFLRLMDLAEDEEMVDLPDETYIRSEYYAYVLIFCQFKKKCGLASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PS91</accession>
    <name>A0A0G4PS91_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chaperone protein htpG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S032g000054</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793165">
        <property type="protein sequence ID" value="CRL29018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PS91"/>
    <dbReference type="STRING" id="1429867.A0A0G4PS91"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.790:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.80:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11260:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000001">
        <property type="entry name" value="Heat shock protein HSP 90-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="9">
        <location>
            <begin position="25"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="213"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="674"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="214"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="676"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="98"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="118"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL29018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="697" mass="79525" checksum="70E69368BA960A0E" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PTL5</accession>
    <name>A0A0G4PTL5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S036g000060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793169">
        <property type="protein sequence ID" value="CRL29476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PTL5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL29476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="184" mass="20983" checksum="F2075618C73A8660" modified="2015-09-16" version="1">MDNHGSHYTPEFINFAVDNGIIPYCFIPYITHICQPLDNFPSSITNSPPLGISRINESTRKLEADIELLDSKLYPTIRHRAKLLCRSARITAELATQLTKDNTTLLRHKAHRDTRVTKRQINLGGPLTAGDTNRIIRARESKEQVQEEKRLKKRTSKQLTTEDTPTPAPRFIPWIPPMDDVSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PTR2</accession>
    <name>A0A0G4PTR2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S041g000002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Penicillium</taxon>
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    </evidence>
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    </evidence>
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        <source>
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            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Goarin A."/>
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                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Lytic polysaccharide monooxygenase (LMPO) that depolymerizes crystalline and amorphous polysaccharides via the oxidation of scissile alpha- or beta-(1-4)-glycosidic bonds, yielding C1 and/or C4 oxidation products. Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">Has a modular structure: an endo-beta-1,4-glucanase catalytic module at the N-terminus, a linker rich in serines and threonines, and a C-terminal carbohydrate-binding module (CBM).</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NTM4"/>
    <dbReference type="STRING" id="1429867.A0A0G4NTM4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF36">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 15" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12 15" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195133" description="AA9 family lytic polysaccharide monooxygenase" evidence="17">
        <location>
            <begin position="17"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="18">
        <location>
            <begin position="339"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CRL17393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="379" mass="38311" checksum="816C39E8B78581F1" modified="2015-09-16" version="1">MYSLLGPALFASLVAAHGHITNIVINGVSFNGWDINSYPYTESPPTVVAWGTPNTGNGFIAPDAYTSSDIICHQNATNAKGHAVVAAGDRVFLQWTDWPDSHHGPVIDYLASCGSTGCETVDKTTLKFFKIDGVGLVDDTTVPGTWGDDQLVAQNSGWMVEIPPDIAPGAYVLRHELIALHSAGTEGGAQNYPQCFNLQITGSGSEQPAGVLGTDLYSPTDAGILVNIYTSLSTYVVPGPTLYSGAVSITQTTSASTASGTPVTGTGTGAAAGGTTATATATATAEATTTSKATTTTLATTTRATSPVPTTIKTSAIRKPVAATPSTTPSTAAAGGGGATQTLYGQCGGTGWTGATACASPASCSSSNPWYSQCVPTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NTP9</accession>
    <name>A0A0G4NTP9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">alpha,alpha-trehalose-phosphate synthase (UDP-forming)</fullName>
            <ecNumber evidence="1">2.4.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S001g000427</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>D-glucose 6-phosphate + UDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="2.4.1.15"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.4.1.15" evidence="1"/>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NTP9"/>
    <dbReference type="STRING" id="1429867.A0A0G4NTP9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000208">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000007">
        <property type="entry name" value="Trehalose-6-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF75">
        <property type="entry name" value="SYNTHASE SUBUNIT OF TREHALOSE-6-PHOSPHATE SYNTHASE_PHOSPHATASE COMPLEX (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL17467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="482" mass="54340" checksum="FD1F8BE39F908EAB" modified="2015-09-16" version="1">MGAITDEKRNLIIVSNRLPLSVKQVDGAYQSSLSSGGLVTSLSGLTKSTKFQWFGWPGIEVKDPKDREDVQKSLEAHNAIPIFLDSSLAHEHYNGLSNRILWPVLHYQSGVVFDETPWQAYRRVNELFADAIAETADSGSLIWVHDYHLMLLPELLRDRLKQRGKSCAIGFSLHTPFPAGDFWRNLPVRKHLIEGMLSSDLIGFHTDEYKQNFIDTCASLLNARTEIPNQIQYKNRLVCINKFIVGIDPEKFTDSLQKPDVQERIRSLKERYKGVKVIVGVDRLDHIKGLTQKLKGFDAFLDDHPELQNKVVLIQVAVPSREDVKEYQDLETELSTIAGKINGKHATPEGTPLLYMHRSVPFNELTALYSVADVCLLTSTRDGMNLVAFEYVACQEERHGVLVLSEFAGAASFMTNGSIPFHPANKTEMSEAIFNALNLDPAERKAKYEYLRGFVNANTSAKWGETFIEKLSLRCRRPGESC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NUA0</accession>
    <name>A0A0G4NUA0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heat shock protein Hsp70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S001g000621</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NUA0"/>
    <dbReference type="STRING" id="1429867.A0A0G4NUA0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
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</entry>
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                <person name="Dupont J."/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="AlphaFoldDB" id="A0A0G4NV88"/>
    <dbReference type="STRING" id="1429867.A0A0G4NV88"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF17">
        <property type="entry name" value="SCFA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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            <begin position="17"/>
            <end position="46"/>
        </location>
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        <location>
            <begin position="46"/>
            <end position="116"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="618"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="636"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL17970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="737" mass="82597" checksum="72785DBE303CFDF0" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NVF7</accession>
    <name>A0A0G4NVF7_PENC3</name>
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        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S001g001018</name>
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    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
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    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
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        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Papain-like_cys_pep_sf"/>
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        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
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        <location>
            <begin position="931"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="12">
        <location>
            <begin position="1298"/>
            <end position="2021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="137"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="275"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="383"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="436"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="753"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1252"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1656"/>
            <end position="1730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1764"/>
            <end position="1813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2042"/>
            <end position="2135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2173"/>
            <end position="2217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="278"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="790"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="825"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="838"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="902"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1267"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1673"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1708"/>
            <end position="1719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1765"/>
            <end position="1787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1791"/>
            <end position="1803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="2051"/>
            <end position="2062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="2116"/>
            <end position="2127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CRL18058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="2217" mass="241931" checksum="2F09041D67965817" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NVI2</accession>
    <name>A0A0G4NVI2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S001g001048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL18088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NVI2"/>
    <dbReference type="STRING" id="1429867.A0A0G4NVI2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL18088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="205" mass="23381" checksum="68FE272061978782" modified="2015-09-16" version="1">MPRIRHHRRHHTWPHCGSELCMREPAGLGMHVSKLGDGPTTYIPLFFPETTVAPLSTEEFLCDDMGMPELSRQPKRMPRLWFRSSIKGRSDQSSLSGSSGQTKQVYRSVVRRLTRRPSWSKTRSLLVVPSNMRSSDSFIMSSLITPHDVSEQTGFSGSDRGRSSVTKADAARCTAERQNRRCHSEQPRAWRKPSATLWTLQEQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NVM6</accession>
    <name>A0A0G4NVM6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutathione-dependent formaldehyde-activating, GFA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S001g000989</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL18029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NVM6"/>
    <dbReference type="STRING" id="1429867.A0A0G4NVM6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="4"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL18029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="140" mass="15608" checksum="AB37CE1EAB2AA496" modified="2015-09-16" version="1">MPTLTGSCICRNIEYELKLASIDDARTSLCHCRNCKKAFGTNYGLTAKVPKNTFNLTKGIPKEHVADNGSGAVIHREFCQNCGSFILEYGDAAKDRFRYICVGSLDDPEALPPKGEFFCKARASWMPEIPNIFHKQTVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NVQ1</accession>
    <name>A0A0G4NVQ1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Berberine/berberine-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S001g001004</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL18044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NVQ1"/>
    <dbReference type="STRING" id="1429867.A0A0G4NVQ1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF17">
        <property type="entry name" value="OXIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005194818" evidence="6">
        <location>
            <begin position="19"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="54"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL18044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="486" mass="52627" checksum="A5DD4811D92F76A5" modified="2015-09-16" version="1">MLLRLLFLAVGATSVAFAGSNEALRSCFKNALTSFAMAGDLFYDRIVNRYNLNIPVTPAAMTFPTSSQQVAAIVQCAAENGYPVQAKSGGHSYGNYGLGGTDGAVAIDLKHLQQFSMDNTSWQATIGAGSLLSDVTQRLYHTGGRAMSHGICPQVGSGGHFTIGGLGPTSRQFGAALDHVLEVEVVLANSTIVRASDTENQDLFWAIKGAASGYGIVTEFKVRTEPEPGTAVQYAYSLEFGDLKQQAALFKSWQAFVSDPELTRKMASTLTVLEKSMAISGTFFGTKEEYDKLNLGSKFPGANGSALVFDNWLGLVAHWAQDAILGLAAGIPTNFYAKSTSWTPQTLMAPETIDKMFDYIGTVDKGTLGWFLLFDFQGGYTNDIPTDATSYAHRDVLIWLQSYTINLLGHISQAQINFLDGLNKIVTNDALPYTAYPGYVDPLMPNAAEAYWGTNLPRLQQIKEQIDPNNVFRNPQSPSPAKKEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NW06</accession>
    <name>A0A0G4NW06_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S002g000034</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NW06"/>
    <dbReference type="STRING" id="1429867.A0A0G4NW06"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23813">
        <property type="entry name" value="UBCc_UBE2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000020">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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</entry>
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            <fullName evidence="6">Protein YIP</fullName>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <text evidence="2 6">Belongs to the YIP1 family.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN YIPF6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="211"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
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        <location>
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            <end position="272"/>
        </location>
    </feature>
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        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
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        <location>
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        </location>
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        <location>
            <begin position="1"/>
            <end position="77"/>
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        <location>
            <begin position="18"/>
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        </location>
    </feature>
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            <begin position="49"/>
            <end position="58"/>
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    </feature>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL18441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="297" mass="31758" checksum="8CE54D8048706C60" modified="2015-09-16" version="1">MATVHRGHPHDEPHDDDSLLGDDLIEADDAVDADDPLRDTDTAPLRGNIESSSSNRGNVSGYGNYLASSMGGEDRRATQNTIDESVWETLSRDLIAVWEKMRQVLWPKYLLGGMMQRGGSGTADSEQGGVSGFGGNIRGLVGRWPDADVVLQGGMSDGLRDWDLWGPLVFCLVLSLFLSVAKGDQSSVVFSGVFCLVWIGEAAVTLQIKLLGGKISFFQSICIIGYTLFPLVIAAMLSAVGLPTIARIPVYLVLVAWSLAAGVSILGGSGVVRNRVGIAVYPLFVFYIAIGCLCFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWT0</accession>
    <name>A0A0G4NWT0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FeS cluster insertion</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S002g000380</name>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
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        <property type="entry name" value="Esterase_713_like-2"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <end position="223"/>
        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL18510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="598" mass="65262" checksum="E67C2C8C9D9D9B6E" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NX97</accession>
    <name>A0A0G4NX97_PENC3</name>
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        <recommendedName>
            <fullName evidence="7">37S ribosomal protein S25, mitochondrial</fullName>
        </recommendedName>
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        <name evidence="9" type="ORF">PCAMFM013_S002g000613</name>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
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                <person name="Sallet E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">FM 013</strain>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS23"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RSM25"/>
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    <proteinExistence type="inferred from homology"/>
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        </location>
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        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011526"/>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR029764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL18743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="259" mass="29932" checksum="98EF56DDF35FC686" modified="2015-09-16" version="1">MGKINLTALRVRQTALNQFASGKTSKLPQWVSVVGEIPPAETLIRTRPPQHQLVQQRLKTVAGSSKPQVVFQVQEKRRKPKKPSRLFQPVELKYEEDQLRTQFFRDHPWELARPRVLLESTGKDFEHYDWSRIQQPGKRLDGESVVQRQLWLLNNVPDMKKSAAYDIARREFYRLRLQEDIQRRVAAEEAAAYGAEFGPSYMDIGMKMENEQYDKWVAWARETSLVQDQRKSALSGAPDLGDTTESSEHEAEEPEAVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXX2</accession>
    <name>A0A0G4NXX2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S002g000785</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4NXX2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
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        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="80"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="640"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="778"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="640"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="670"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="788"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL18915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="854" mass="94018" checksum="3C0BAAF151AF332F" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NY03</accession>
    <name>A0A0G4NY03_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S002g000806</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NY03"/>
    <dbReference type="STRING" id="1429867.A0A0G4NY03"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL18936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="275" mass="30544" checksum="95B640FFC1194AF7" modified="2015-09-16" version="1">MPKVFLVTGTSSGFGHDLIQEILNRGDIAIATARTPAILEFDNTTENNYMTLKLDVTNTESIKEAFAEAIKRFGRIDVVVNNAGYGLTGCFEEYTEEQIRMQMEVNFFGLVNVTRESMSTMRTQKPSGGVIQQVTSVGGQRGAACFSLYAASKWAVEGFTESISKEVKPEWGIKFTCVEPGGFRTDWAGRSMAFTERHPEYDHLDAKGLMMARNGTQPGDPRKAAKAFYDLAMIEDPPLRVLLGTDAYPAILARLEEEKRNFMKYEGISLSTDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZ71</accession>
    <name>A0A0G4NZ71_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-grasp fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S003g000157</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZ71"/>
    <dbReference type="STRING" id="1429867.A0A0G4NZ71"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052032">
        <property type="entry name" value="ATP-dep_AA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041472">
        <property type="entry name" value="BL00235/CARNS1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43585:SF2">
        <property type="entry name" value="ATP-GRASP ENZYME FSQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43585">
        <property type="entry name" value="FUMIPYRROLE BIOSYNTHESIS PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13535">
        <property type="entry name" value="ATP-grasp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18130">
        <property type="entry name" value="ATPgrasp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="5">
        <location>
            <begin position="318"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL19366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="681" mass="74902" checksum="713A7DBE6B5AD676" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZW7</accession>
    <name>A0A0G4NZW7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid transporter, transmembrane</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S003g000408</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZW7"/>
    <dbReference type="STRING" id="1429867.A0A0G4NZW7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF683">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="52"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL19617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="470" mass="50164" checksum="9DB55FDD0619EEF4" modified="2015-09-16" version="1">MAEKQNKMSDDIEASGPITYVPSQAGEIIKEENITHDPVFGEVTEDGPNYRNVGWLGTVALMMKTQIGLGVLSIPSVFDTLGMVPGVILLCIVAGIATWTSYMVGVFKIRHREVYGIDEAGGLMFGRIGREIFGIGFSLYWIFVAGSGILGISISLNAISNHGTCTAAFVAVAAVIGFSLASIRTLGKITWIAWVGLICILSAVLIVTVSVGIQDRPSSAPQEGPWSSDFKITNSPTFAQGVAAVSSLIFACSATPAYFSIAAEMRDPRLFTRSLVVSQLGSTIIYLVIGIVVYYYCGSDVASPALGSAGPLIKRISYGIALPGLIASTTIVLHLPSKYVFVRILRGSDHLTSNTLTHWAIWLSCTLGSTIVAYLIASGIPFFNSLVSLIGACLGASLAYQPTGCMWFYDNWGSTDRTWRWKFMACWSVFIIVIGTFMTVAGTYGSIVGIIDSLKAGGSPPWTCADNSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0D0</accession>
    <name>A0A0G4P0D0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aspartate/other aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S003g000556</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P0D0"/>
    <dbReference type="STRING" id="1429867.A0A0G4P0D0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF55">
        <property type="entry name" value="GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="41"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL19765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="421" mass="46281" checksum="0CED49561D3E3328" modified="2015-09-16" version="1">MGSIATTTFPDPFQGVPVARAADGLAALGGKFRADTDPNRTDLLVGVYKTDDGKAYSQPSVKEAKNRIFNDPDWHHEYRPSAVGSPGYRDLSSKLLFGADSRLLREKRIVSAQTLGACGGCHAGAVLLKNHYGPWKENGNPEIFLPTDSWLNHPFVFQSAGIKTSLLPYFNSKTNTFDFEKFSEAIKSLPTQSVILVQSGAQNPTGCDPSPEQWQELASIFSERGHLAFFDAAYPGFASGDIDADLAGVRLFAEQEIPFIFVSTYGKSFGLYSERVGIISVLVPNEQAGKNIEAQFSLLARSESGAPPDFGSRIVETILSDKVLEHQWREEVRDMANQLKNRRVALREALEKLETPGSWRHITEQTGMFSYVGLSVEQVTLLREKYHVYLQDSGRISIAGLNSSNIDHTARSISAVVKATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P152</accession>
    <name>A0A0G4P152_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S003g000838</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL20045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P152"/>
    <dbReference type="STRING" id="1429867.A0A0G4P152"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF151">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="31"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="313"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL20045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="351" mass="38834" checksum="0029DEAC20292ED3" modified="2015-09-16" version="1">MTTANVQDSYQGSYRAGTIAMTALGVGFVILRFLARWKKSLKPGPDDYVILAALVPFLTLVGLMLALVNYGMGTHSEILPMGNIIMIAKLLVIFECIYVTTIAVTKVSILLMYCRIFPTREIRISSIILGGISIAWGMAIILVSVFQCTPIARAWDTRIPGTCINLKASFIGNAVPNIITDILILSLPVRVVWGLHASITHRLSVIGIFLLGSFVIFTSVYRFTTLFEFNPTDIAWTLGKSCTWCIVESSTGIISACMPTLRPLFLMVSSKFSSQSGTQKTRTTDIDRSKGYELDNSTLRPANELRNKTKVRLDVSHPDDGSEDEVPLNAIRVQQDMTWQESRGDSFQGYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P157</accession>
    <name>A0A0G4P157_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isochorismatase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S003g000806</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL20014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P157"/>
    <dbReference type="STRING" id="1429867.A0A0G4P157"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01014">
        <property type="entry name" value="nicotinamidase_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF15">
        <property type="entry name" value="BLR5631 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="24"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL20014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="196" mass="20965" checksum="B25107656179ED95" modified="2015-09-16" version="1">MSSIKSFRELIGIPPSSASTTDSTLIIIDAQNEYATGLLAVEKVAESRKVISKLLEKYRQGNGKNIVHVVHEVPAGAPVFTPSSALAQVFEELTPKPNEKVVTKNFPSSFAKTDLHEYLQGLGEVGKKIVLVGYMSHVCISTTARAGSELGYDVVVVRDAVGDRHIPGADAETVVRVVLSELGDGFATIVSESEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2D9</accession>
    <name>A0A0G4P2D9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S004g000353</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclophilin-type PPIase family. PPIase D subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P2D9"/>
    <dbReference type="STRING" id="1429867.A0A0G4P2D9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000029">
        <property type="entry name" value="peptidyl-prolyl cis-trans isomerase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0697">Rotamase</keyword>
    <keyword evidence="5 8" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="9">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="239"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL20413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="302" mass="33384" checksum="B8D28756511BB261" modified="2015-09-16" version="1">MIQGGDFTAFNGTGGESIYGEKFPDENFDLKHDRPFLLSMANSGPGTNGSQFFVTTVPTPHLDGKHVVFGEVINGKSVIRKIENMKTQSDKPFQDVTIVDCGELSGEDYENATKRQQDATGDPYEDFTEDHQGEALTAPLCFKIASDLKGFGNAAFKSGDLNLGLDKYQKGLRYLNEFPEPEENDPKELDEQMKALRFTLHSNSSLLGNKLQKFRQAQNWATYALQVADSAKAKDADKAKAYYRRAVAHEGLKEEDAALKDLQEAEKLAPGDAGIINEIAKVKKTVKDREAKDKAAAKKFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2P7</accession>
    <name>A0A0G4P2P7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxoglutarate/iron-dependent oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S004g000459</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P2P7"/>
    <dbReference type="STRING" id="1429867.A0A0G4P2P7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="214"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL20518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="366" mass="41121" checksum="59A06BA5D3A7FDDF" modified="2015-09-16" version="1">MTESKTESSQLADCKNIPIIDLSSLDSPNFDERRKLAQSIYDACTQVGFFYIKASGSYRTLELHQILILPVQNHGIPEDKINGIHGSAKRLFDLPEEQKMKFYIGNSPKFRGYSPLGGEKSTGTDDDPIAEEDAVSALSEAFDIGYETAMDPQKSKDDPLPHDPYILYGDNQWPSQDILPNFTETYVEYCVMMLGLCRKLMRIFALALELPEEHFDSMIKNPGVTSRMMHYPPQPVKEEVREGLGAHTDFECFTILSQGSVPGLQVLSHSGEWILAPPLSGTLVVNIADCLSIWTNKKFKSTIHRVTNLTGQERYSIPFFFGVDYDTTVSVLPNHISDDRPACKEPFKAGEWVREKLSKAYVGYEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2U6</accession>
    <name>A0A0G4P2U6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S004g000587</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P2U6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL20646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="251" mass="29033" checksum="6DFED6678DFEF4E7" modified="2015-09-16" version="1">MEHDIGPAPSGFFTGVKLADPDEDISTRLKRWYLIYRIETDARGLDRCWKRGTPGQISWNTHEYHPFIRSLAVWDSAFQYFQRPSLENIAKTCLWWQSIVGEKWPVLVHFYGSLFYIRAEYPMTDRDFWFRIHRLLRSPSVQHITFNRGFDDKFISGPESVKSILPMNAEPPREMLQSSLSTIVEKECGTLESVIATERSAGKVPKPLSGPGIEKEAPIFNTFGTHWFEHKGVQCQVMIDMADRFESPTDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2V2</accession>
    <name>A0A0G4P2V2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S004g000591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P2V2"/>
    <dbReference type="STRING" id="1429867.A0A0G4P2V2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009836">
        <property type="entry name" value="GRDP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365">
        <property type="entry name" value="ENOLASE (DUF1399)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365:SF7">
        <property type="entry name" value="GLYCINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07173">
        <property type="entry name" value="GRDP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL20650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="719" mass="80170" checksum="80A0866082FB547A" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3A6</accession>
    <name>A0A0G4P3A6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Armadillo-type fold</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S004g000748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTI2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P3A6"/>
    <dbReference type="STRING" id="1429867.A0A0G4P3A6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110078">
        <property type="term" value="C:TTT Hsp90 cochaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018870">
        <property type="entry name" value="Tti2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32226">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32226:SF2">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10521">
        <property type="entry name" value="Tti2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL20806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="571" mass="62818" checksum="CA92766EE6E5E3CE" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3C0</accession>
    <name>A0A0G4P3C0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Intradiol ring-cleavage dioxygenase, core</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S004g000699</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P3C0"/>
    <dbReference type="STRING" id="1429867.A0A0G4P3C0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018576">
        <property type="term" value="F:catechol 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009712">
        <property type="term" value="P:catechol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007535">
        <property type="entry name" value="Catechol_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050770">
        <property type="entry name" value="Intradiol_RC_Dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711:SF5">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASE PRCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04444">
        <property type="entry name" value="Dioxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catechol dioxygenase N-terminal" evidence="9">
        <location>
            <begin position="25"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="8">
        <location>
            <begin position="107"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="287"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL20758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="318" mass="35213" checksum="7BB7C5A9CFD3E728" modified="2015-09-16" version="1">MSSTRQFDPTFTPSVINGMGPKTPERARVVLGSLIKHIHDFAREVELTSAEWMLGVEFINSIGQISTPIRNEGHRICDVIGLESLVDEIANKIVTEDGVSPTSNVILGPFWSPNAPFRALGDSIIQDPKPNGRVTFMHGVIKDMESGKPIVGAVLDIWQASANGQYDFQDPTQTDNNLRGKFRSNEKGEFNWYCYHPTPYSLPTDGPAGVLLNLMDRSPMRPAHIHLMITHPEYATVINQIYPSDDPHLAIDSVFAVKDDLVVDFKPKTNDPKASLDLEYNVKMALKKHHPNPNSAPPVSSFERHAKAAKEAQAQGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3Y6</accession>
    <name>A0A0G4P3Y6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S005g000173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P3Y6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL21009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="246" mass="28140" checksum="07FE6B04BCD71B20" modified="2015-09-16" version="1">MLRSVTCRMTDALGRPPISSSRPCPRPTSAFPIVVHCSMLVAITLNFLSTLCQQTIGRLLPINVDRFTIFHQRKVMDDPQDQAFSCSIIPLSTTERTDFSTLGCMVYGYPSTGGFLVKEADLLDMLFLSLPRSYVSQRSPSADEEDRFCSLLRRTGATFWPSKRDWFNVQVGLREITEEEEKVIVYGWPTDEVGVWVLRFRSARELPDDFGRMRLAMNMEEKIQIMREYGATFVENVTQVEELNTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P480</accession>
    <name>A0A0G4P480_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">rRNA methyltransferase 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PCAMFM013_S005g000246</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
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    <keyword evidence="6" id="KW-0808">Transferase</keyword>
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    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="290"/>
            <end position="372"/>
        </location>
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        <location>
            <begin position="704"/>
            <end position="1070"/>
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        <location>
            <begin position="56"/>
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        </location>
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        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
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        <location>
            <begin position="91"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="118"/>
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        </location>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00034881"/>
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        <source>
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        <source>
            <dbReference type="EMBL" id="CRL21082.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1075" mass="117681" checksum="C2610F26A00FDEB9" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P4U0</accession>
    <name>A0A0G4P4U0_PENC3</name>
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        <submittedName>
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        </submittedName>
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        <name evidence="5" type="ORF">PCAMFM013_S005g000483</name>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SOWAH (DROSOPHILA) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANKYRIN"/>
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        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="49"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
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            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="136"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL21319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="386" mass="43336" checksum="E56DB870C3880F72" modified="2015-09-16" version="1">MSILKLPPELLMSIAEALECRDLNMLLQCHSYLYKTLNDSLYQLNVQHHDASALYWAASSGSDKTLQRLLDAGANVQWESPYFACSVQKPGTRLRRCIWKENMKEHPISYAAAQGYLNIVEHLLDLGVDINYRDADGLTPLALAAREGHFPLTRALINQGAKQLSHDTMGQYPLAQAASKGYHDIEDYLFEKLRQYPYGKTSPGLDLYWMLKYAAERGDDDRIRYLLSQGADVNFQLPIESHSPLCGALAYAPSPFSTVKLLLEVGADPNRKASRSIDYQPGRPAREQAPLKLAVPRDESIGLIKLLIQYGADASKQSLALLTAIQHQKAAEFRLLIDNGARLDADYRRVSVAWRGINCGYQPIIDICLEHRVSPDDRRLIRAGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P512</accession>
    <name>A0A0G4P512_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Plectin/S10, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S005g000558</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4P512"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Plectin_eS10_N"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007278"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03501"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL21394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="163" mass="18579" checksum="7FE3A6702886F5B6" modified="2015-09-16" version="1">MYVSSLIPKDDRKKIHEYLFREGVLVAKKDFNLPKHGDIDTKNLYVIKALQSLDSRGFVKTQFSWQYYYYTLTPEGLDYLREWLHLPAEVVPATHIKQQRSHAPPRGMMGGEEQRGERRGPRAPREGGYRRREEGGKEGGAPGEFAPSFRGGFGRGRGAAPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P541</accession>
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        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
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        <name evidence="3" type="ORF">PCAMFM013_S005g000595</name>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CRL21431.1"/>
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        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
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        <location>
            <begin position="152"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="SigF-like NTF2-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL21431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="211" mass="24677" checksum="F6D4867E2D62E331" modified="2015-09-16" version="1">MENPVADIPTVIQHLTQSPPSLQETVLKQYFTNNASFVHPFCRVPNFEGSRWWVSKIFQWYKIMSPRIELEIHSIAFDEDKLKLYVNMSQIFSIWLVPFHVAPVTLTTVLDLTHDSVKSQATTNGDHKLYYISKQEDLYQTSEFVKFIMPHIGYWIVFGWHLFATFFCVLGVSLLWPILWLEEEGYIPGRFLRGGNLAYNMEKKIPEIKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P620</accession>
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        <submittedName>
            <fullName evidence="8">Peptidase M14, carboxypeptidase A</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">PCAMFM013_S006g000306</name>
    </gene>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
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        <text evidence="5">Belongs to the NRP synthetase family.</text>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:secondary metabolite biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Nonribosomal siderophore peptide synthase SidC"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
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        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
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        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
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        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
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        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
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        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
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        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
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        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="7"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="8" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
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            <end position="1054"/>
        </location>
    </feature>
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        <location>
            <begin position="1529"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="2075"/>
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        </location>
    </feature>
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        <location>
            <begin position="1051"/>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL21766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="2627" mass="289998" checksum="D254D0213475EBE4" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P681</accession>
    <name>A0A0G4P681_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Permease, cytosine/purines, uracil, thiamine, allantoin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S006g000324</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P681"/>
    <dbReference type="STRING" id="1429867.A0A0G4P681"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF17">
        <property type="entry name" value="VITAMIN B6 TRANSPORTER TPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="382"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="420"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL21784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="490" mass="53752" checksum="B93F226DC9E9C619" modified="2015-09-16" version="1">MNNYNESIQKPQSETETVKPHRPFFNGRFSIEEGGIERVTDEERQQNTTKFWHAATFWFSANMAVATLNIGSLGGSLGLPFWDCFIVILIVNITSNLLPAWTSVFGLTGLRMTTFSRYSFGYWGNMLVVIFSMIATTGWNAINSISGAAVLHAVSDGRFPIWAGVIVICVAVWVICVLGITWIHRLDTFIWIPPLIVWCVAAGTGASQLTGEDHSRLQGSDKAAAILTFMALIFSFSVSWVNCAADYNVRMPKDTPRWQIFGATYVGISVPTVLVQTLGAALYTGTMANTAWKEAYAASSIGGLLKMALEPAGGFGKFLMVLAALSSIPNNIPNNYSFALHAQNLGQWAIRIHRVVMVTFGFIAAIIVGCCAAQYFSDTLQTLLSVIGYWTVIHITLVMEEHFIFRRGWKGYDFDAWNSAANLPFGWAAIGAFAFGFLGAALGMKTAWYSGPIASLIGKKGANIGHELTFAFSGVVFPLFRWIEKHYGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7P7</accession>
    <name>A0A0G4P7P7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Band 7 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S007g000322</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P7P7"/>
    <dbReference type="STRING" id="1429867.A0A0G4P7P7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13437">
        <property type="entry name" value="SPFH_alloslipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000004">
        <property type="entry name" value="Putative membrane protease family, stomatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF19">
        <property type="entry name" value="AT06885P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="3">
        <location>
            <begin position="79"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL22341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="341" mass="36950" checksum="996DCACCCA12567F" modified="2015-09-16" version="1">MSENGASTSKAPVTNRGIDHPLVDVQPFRMSDLQPKYAHQIDHADDNPDAHGWYAGLIHSLGECIGFFGAIPCCICCPNPFKPVDQGAVGLISRFGRFERSVDPGLVKINPLSEHIITVDVKIQIVEVPRQVCMTKDNVTLNLTSVIYYQVVSPHKTAFGISNVRQALIERTQTTLRHVIGARVLQDVIERREEIAQSTSEIIEEVASGWGVKVESMLIKDIIFSNDLQDSLSMAAQSKRIGESKVIAARAEVESAKLMRQAADILSSAPAMQIRYLEAMQAMAKTANSKVIFLPGVAPNVSQQLEAATNAGEGPSNYGAPTSSNDGGFQGAINARVVEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P827</accession>
    <name>A0A0G4P827_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily, general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S007g000441</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P827"/>
    <dbReference type="STRING" id="1429867.A0A0G4P827"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF77">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="19"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="CRL22460.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="511" mass="56127" checksum="03D4505E7030A61C" modified="2015-09-16" version="1">MAGLHLNIDWKSNRRAIAYCLVAAIGALCYGYDTIYYTGIQGMTWFAKDYGEQNADGSYSLGTSFLSLSASIIYVGELVGALAAAPINDFFGRRVVFLSASLCIVIGAIVQVCSFGSDPVFYISRVLIGLGVGQFTATCLMYIGEVAPSAIRGPALMCFQFMQSVSQLVGACVNQGTQSISSAQSYRIPMCLLVVLPGIMLLCLPFTPESPVWYMYKGKREKAIKALRKINHSCRDYDPSVDIQAIDDQVQMEREMAKDATWMSLITDPIERRKLFYACGAMFVQQINGIQFWYTYGVVFAQSIGVADPFTINTIIYVLQIITVGVAVVLGNKIKRRTNLIICSAGIFVSLIAVGGLGTTRSPDGTFGRGIGIGIVVLAYINIIFYNFSIGTLSYSIASEMSVGRNRNKITSCAMAVFFLTVWLMVFTSPYMYYTANLGPMIGFVYGGTTLFLLAYSWFCVGETAGRSNAEIERLFQDRVPVRQWATYVIPSDDGVVMKKQGTEDEQIEMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P858</accession>
    <name>A0A0G4P858_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Double-strand break repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PCAMFM013_S007g000471</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR. It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation, which is required for single-strand invasion and recombination.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the MRN complex composed of two heterodimers RAD50 and MRE11 associated with a single NBS1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17 19">Belongs to the MRE11/RAD32 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P858"/>
    <dbReference type="STRING" id="1429867.A0A0G4P858"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097552">
        <property type="term" value="P:mitochondrial double-strand break repair via homologous recombination"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:telomere maintenance"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Mre11_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
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    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00583">
        <property type="entry name" value="mre11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139:SF1">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04152">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000882">
        <property type="entry name" value="DSB_repair_MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01347">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 17 19" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 17 19" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 17 19" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11 17 19" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10 17 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 17 19" id="KW-0464">Manganese</keyword>
    <keyword evidence="15 17 19" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 17 19" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14 17 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mre11 DNA-binding" evidence="22">
        <location>
            <begin position="290"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="529"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="491"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="533"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="572"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="589"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="635"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="674"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="724"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="758"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="18">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009028"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="RuleBase" id="RU003447"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL22490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="780" mass="87384" checksum="6BDA6F1AC5F2ED79" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P884</accession>
    <name>A0A0G4P884_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S007g000488</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793140">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186:SF4">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195324" evidence="1">
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            <begin position="21"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7580" evidence="2">
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            <begin position="197"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL22507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="545" mass="62997" checksum="B4AFF1DD6E56A1C0" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P8Y0</accession>
    <name>A0A0G4P8Y0_PENC3</name>
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        <submittedName>
            <fullName evidence="8">Lethal giant larvae (Lgl) like, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S008g000163</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
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    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4P8Y0"/>
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    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045159">
        <property type="term" value="F:myosin II binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000848">
        <property type="entry name" value="SNARE-dependent exocytosis protein (Sro7), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013905">
        <property type="entry name" value="Lgl_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241">
        <property type="entry name" value="LETHAL 2 GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241:SF25">
        <property type="entry name" value="TOMOSYN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08596">
        <property type="entry name" value="Lgl_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="240"/>
            <end position="269"/>
        </location>
    </feature>
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        <location>
            <begin position="514"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="912"/>
            <end position="938"/>
        </location>
    </feature>
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        <location>
            <begin position="912"/>
            <end position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL22734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="996" mass="108049" checksum="F515D708E31C5555" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P9C4</accession>
    <name>A0A0G4P9C4_PENC3</name>
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        <submittedName>
            <fullName evidence="7">Tetraspanin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S008g000329</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P9C4"/>
    <dbReference type="STRING" id="1429867.A0A0G4P9C4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL22900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="267" mass="30677" checksum="A79E2E27428F1E17" modified="2015-09-16" version="1">MPFKVDATVLLYITFIVGGVISLLLGAISWARTATLLLPLPIWVPAITTLISPIMVLTLIVTRILSTRSNNETTRTYRWTTISRILDQVQTVISTIVATVALAYLFPDRTLSCNLDQRWQEFFKSKNSHAIRSIQDEFRCCGLRSLHDRAWPFKDRNHGDNACELQLRYQRSCFAPWREHQHRTSWMVFAAVVLVFAAKIAFIRLSGHRTSWMSAQSQSASRGADYQRISHPEVQDEGDIENGIHEETRRTLLPQSNAEYRNNWEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P9J0</accession>
    <name>A0A0G4P9J0_PENC3</name>
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        <submittedName>
            <fullName evidence="3">Putative stress-responsive nuclear envelope protein Ish1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S008g000394</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P9J0"/>
    <dbReference type="STRING" id="1429867.A0A0G4P9J0"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018803">
        <property type="entry name" value="Ish1/Msc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10281">
        <property type="entry name" value="Ish1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0261">Viral envelope protein</keyword>
    <keyword evidence="3" id="KW-0946">Virion</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195159" evidence="2">
        <location>
            <begin position="22"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL22965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="512" mass="57279" checksum="B65AFF4EC7E20C82" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P9M4</accession>
    <name>A0A0G4P9M4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DASH complex subunit DUO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Outer kinetochore protein DUO1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PCAMFM013_S008g000429</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DUO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL23000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P9M4"/>
    <dbReference type="STRING" id="1429867.A0A0G4P9M4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013960">
        <property type="entry name" value="DASH_Duo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28216">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28216:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08651">
        <property type="entry name" value="DASH_Duo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="166"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="184"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CRL23000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="242" mass="26775" checksum="F035C070DAF06201" modified="2015-09-16" version="1">MAFRTTAEEMERLQLSDDDTEDLWNSPSKRVAQKKINPRTSDEKTTPEPRASHDGQDPLFDQQEAREAALRTELQGVRNINEVIEGLLGSLDSAKGNMETVSQTVTSASTLLNTWTRILSQTEHNQRLILNPNWQGATQDVVDIENQAIQRQQAAERREQALQQQREAAARKAEEIEKRRAQVTRGTRGTRGTTRGTVRTTGLGRTPSVSTTRTATRGSTTSQRPASGIARGSGISRGRGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAD9</accession>
    <name>A0A0G4PAD9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Siderophore transporter, RhtX/FptX family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S009g000205</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PAD9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000188">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF50">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="62"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL23265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="509" mass="56414" checksum="4F7EC8386A9FE789" modified="2015-09-16" version="1">MSSSARASSPDGAVKKTDTLGTAEEPNTLKGYGSVPGVIDEVTRVVDHKAERRLCRKFDYRLLPILAVMYLFNALDKGNLGNAETDGMSKDLNFKPNEYNLLLSIFFVPFVIFAPPFSMLGKKFSPARVLPILMFSFGSLTILSSAAYNFSGMFALRWFLGMSEAAFFPLVIYYLTTFYRRGELARRLAVFYAASNIANAFSGLIAFGVFQIKGSHIPNWRYLFIIEGGVTVLFAIFAFFYLPRSAAEAKFLSEEEKALAFHRVQVDSSAVVNEEFSFREALGIFKHPTTYAFLCIEICLGVPLQGVALFLPQIVGGLGYPTVKTNLYTVAPNVTGAVMLLVLAFSSDWTKLRSPFIVLGFLLTFSGFMIYASIDDVQSDIQVAYFATFMMTWGTSAPSVMLSTWYNNNIAHEGRRVLLTSIGVPLANLMGLVSSNLFRKQDAPKYTPALISVAAFGATGACLTASLALYMWLDNKRRDRSDGVTIRARDIPTERMRDGPASAEFRWFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBI2</accession>
    <name>A0A0G4PBI2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldehyde dehydrogenase, conserved site</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S010g000088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PBI2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PBI2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN LPX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="194"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL23650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="443" mass="48888" checksum="82054C0EC0194078" modified="2015-09-16" version="1">MTISISSSVHAWRSLPDALSPSLETLSHTLNQDPQWQAFINTEGIQHSVTIGVQSTSSDQVILVSVEPGPKTIVTTGPSSNADFVLVAQAEHWEKFFSAKPSAPFTSFVGIQGMNIVQDGAGVHGNHTKYSQFVHLSDRLLELLREGLHGPHVEDLQPDTDEDHIVGKYVYIYPPVWGKTKVFYERSGTGSQEILFLHTAGSDSRQYHTVMNDPTMRSKCSMIAFDLPAHGRSFPGKTHLPGNHTNTEDAYVGAIREIIQVLKLNKPIVCGASMAGQVCIAVAIRAEEVGAGGTIPLQGCDYLTMKRQFDDKSPVVNQSLFNPNWIYGMMAPNAPLVNKQLVWHTYSAQAYGIFHGDLDFYFGGFDARDRVSSIDVKKCPIYFLTGEFDWSTTPEMSCATAAKIDGAMFKEMEGLGHFPATESPSRFIPYLLEAIEWIQKTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBM4</accession>
    <name>A0A0G4PBM4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S010g000128</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PBM4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PBM4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF31">
        <property type="entry name" value="STERYL ACETYL HYDROLASE MUG81-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="105"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL23690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="345" mass="37662" checksum="03DFCBA485DB0A8C" modified="2015-09-16" version="1">MAPLALGLGIAVIKSFVIAIWTAIIAPFRGQKGGATAYKHIALSFTRALFRYASMEQIQLVLTPASAQKSYEAHMSQQKASPNILVLAEGTTTFWLGNPAAEKLVIYFPGGAYCLPALPNHFTHLEALSADLKQHGNGIGVLFLAYELAPGARWPRQLQQAVVVLRYAIETLGKRPSDIVLQGDSAGAHLALALLSHLAHPHPQEIVVRFSVDEPLRGAMLLSPWVDFGINHASSRGNADRDIVSAQTLNSWARIFLGQTVEDEYNCPAKAPAGWWRELPVSRIFVGAGGDEVLLDPIKETAEMMKASIVPREFHVEPITDFALKLPPGLQFKAMALWLNQTFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCJ7</accession>
    <name>A0A0G4PCJ7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S011g000025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PCJ7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL24031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="52" mass="5926" checksum="8D8BEEA8AFB557C9" modified="2015-09-16" version="1">MHITVDWYGVQKLALDLWVPVRPTEAIPQVPRSNLYELSPIFNMKFGANIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCN6</accession>
    <name>A0A0G4PCN6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S011g000013</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PCN6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL24019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="77" mass="8842" checksum="71F225DD977C6151" modified="2015-09-16" version="1">MQRVVSIFMGRYSFSVPGSGKLVPGIQVCVPGGFWAPRNTRPVPREVHSAPRRRLRGINLYTTIIYPFPELHPTHRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCS8</accession>
    <name>A0A0G4PCS8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carboxylesterase, type B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S011g000125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PCS8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PCS8"/>
    <dbReference type="ESTHER" id="penro-w6qrw5">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195354" evidence="1">
        <location>
            <begin position="21"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="24"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL24131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="550" mass="60499" checksum="B608921F8FEDD05F" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCY0</accession>
    <name>A0A0G4PCY0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2,3-cyclic-nucleotide 2-phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S011g000182</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PCY0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PCY0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22453">
        <property type="entry name" value="KH-I_MUG60_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056553">
        <property type="entry name" value="KH_Mug60-KHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF76">
        <property type="entry name" value="KH DOMAIN-CONTAINING PROTEIN YLL032C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24563">
        <property type="entry name" value="KH_Mug60-KHD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="269"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="567"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="654"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="764"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="846"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="910"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="851"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="981"/>
            <end position="995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL24188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1004" mass="111193" checksum="D9F1D398588091B2" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PD26</accession>
    <name>A0A0G4PD26_PENC3</name>
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        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S011g000148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1429867.A0A0G4PD26"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL24154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="82" mass="9582" checksum="283E3346C59AB387" modified="2015-09-16" version="1">MHRLVIRVQEMFDMHDVFAVNNDGDRLIYVIANREEDSVSLFQELLARGLDARRENNKRLSALDVAMAYGKQGILELFEREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDP4</accession>
    <name>A0A0G4PDP4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Citrate exporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S012g000067</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Transmembrane transporter that exports citrate across the cell membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>citrate(in) = citrate(out)</text>
            <dbReference type="Rhea" id="RHEA:33183"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PDP4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015137">
        <property type="term" value="F:citrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000172">
        <property type="entry name" value="MFS multidrug resistance transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF144">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="396"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="438"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="13">
        <location>
            <begin position="43"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CRL24458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="506" mass="54867" checksum="E027D78F6E28E5E3" modified="2015-09-16" version="1">MNNQDIHQEVERQDDEVNEETPLLRPPTTEPYSVFTSTQKRLIILTAALASSFSPLSANIYYPALNSIAKDLGVSPSQINLTITTYMVCQGLAPMLTGSLADQAGRRPAYILCFAIYIVGNVALALQHSFPALLALRAVQSCGSSGTVALASAVAADIITSAERGMYMGFTSLGNILAPSIGPILGGVLSKYLGWEAIFWFLAIAAGTFFVPLLLFFPETCRGIVGNGSIPAVGWNLAIWSYFQTTTAVSPQGPTLPRRRVNIPNPWSTLRLLSHRPVGLVLLANGVVFSSYYAVTAGIPALFHRIYNLDDLEIGLCFIPAGLGSLLSATANGVLVDWNYRRIRRNAGQTVHKNQKQDIIEFPIEQARLQIGLPMTVLAALSIVVYGVLIPLQPPLLIALIVVFVICFCITAAYNVMNILIVDLYYETPATAMAANNLVRCFLGAGAAAVVNPLIKRIGAQWTYCFVSGAIVLVTPILSIVYLQGWEWRKKQAETDAQLRTVHGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PE53</accession>
    <name>A0A0G4PE53_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S012g000213</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PE53"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000447">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF36">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="400"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="477"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="50"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL24603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="523" mass="56807" checksum="B4750B93A25627D9" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PE56</accession>
    <name>A0A0G4PE56_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase</fullName>
            <ecNumber evidence="4">1.1.1.302</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S012g000164</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27274"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27278"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HTP reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.302" evidence="4"/>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PE56"/>
    <dbReference type="STRING" id="1429867.A0A0G4PE56"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050765">
        <property type="entry name" value="Riboflavin_Biosynth_HTPR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011:SF7">
        <property type="entry name" value="2,5-DIAMINO-6-RIBOSYLAMINO-4(3H)-PYRIMIDINONE 5'-PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G06820)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="Bacterial bifunctional deaminase-reductase C-terminal" evidence="14">
        <location>
            <begin position="36"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CRL24554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="279" mass="29947" checksum="0A05D83F81AA95A3" modified="2015-09-16" version="1">MSSAPRDALEFPESDRGFLEPHLPPQDGSAPQSDLPFTTLTFATSLDSSLALSPGARTVLSGPQSKAMTHYLRSRHDGIVIGVGTAVADDPGLNCRITGVGGYGQEGLAGQPRPVVIDPTARWEFSDDSKLFQLCREGRGLAPWIITAVENPNAQKQALLERYGGRFISVKMIRTHTGRHQIDWPDLLVTLKSNGLGSVMIEGGGQVIKSLLSPPYMSLLDSVIVTIAPTWLGEGGVVVSPARRFDEGGNAISAARLKNVKWYPFGEDVVLCGQIKLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PEL3</accession>
    <name>A0A0G4PEL3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein phosphatase 2C-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S013g000013</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL24771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PEL3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PEL3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000098">
        <property type="entry name" value="Protein phosphatase 2C, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF589">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE [ACETYL-TRANSFERRING]]-PHOSPHATASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="6">
        <location>
            <begin position="116"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="56"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="529"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="537"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL24771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="555" mass="61457" checksum="DE823A0A58EC827D" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PEY2</accession>
    <name>A0A0G4PEY2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aflatoxin biosynthesis regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S013g000136</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL24893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PEY2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045122">
        <property type="term" value="P:aflatoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013700">
        <property type="entry name" value="AflR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08493">
        <property type="entry name" value="AflR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="91"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="123"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="233"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL24893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="505" mass="54991" checksum="6BB56D6C11730F87" modified="2015-09-16" version="1">MNILACYSPPLYRLALNESNQHKLWLIHAKGVCNFSKSAKGPKIAKKNLEISWNAISTLMMFVASQETPMHTHHQNQSKPSKPQRLAFRSSCDPCAASKVRCTKEQLGCSRCVQNGLKCVYGRSRRKGKPPSNKTAPIHAPVHHPYSRAPVSPPAPPAPPIPAQPSWTPGPNHHQPNYNHSCSWYRASNPTEWERRRNTLTPSLTPSLTPGAGISHLSTPEFGWPSMLGSDPMVTDSHSLGSLPEMRGMDDENGGGQEGDEVQHNPEDDQHESCIAVACRTLSSLYQFVQSDCVNGHSTNSNQSRSMLKPPTPEVSPANDIVFCTTRFATETVSRLLNCTARSCAGDPSILLVLGSILLRILTWYEALYQSEIGELGLSATPSPSGREDVGLDGSHSSVTHSIGLSQPSESMEESIYTVPLTIPLTIGTFNLSLATETKMKAQLLLCEVQTLSQVCQALGRRVQAAESIRGEKDLCGQSNTHLLRKLGELRHALTAVCTQVPSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PFN0</accession>
    <name>A0A0G4PFN0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutamate decarboxylase</fullName>
            <ecNumber evidence="3">4.1.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S013g000346</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-glutamate + H(+) = 4-aminobutanoate + CO2</text>
            <dbReference type="Rhea" id="RHEA:17785"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="4.1.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.15" evidence="3"/>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL25103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PFN0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PFN0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010107">
        <property type="entry name" value="Glutamate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321:SF3">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL25103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="437" mass="48723" checksum="633E45344228A2B8" modified="2015-09-16" version="1">MPSNESSTPQHVTVSIPDKGISAEAVGELLQKHMAADIPPSHDLGRFTTTKFDETAINIMVAGSLRNQPCIEEYPSLADFREKCVSMLANLWNAPSGFFGAATTGSSEAVLLGGLAMKRQWQLRYPCHLNSRPNVIIGANAHVCVNKVANYFDVEARIIPVIGVFLTLGSTYTGHYDPIQQVSRVLDEYEHQTGNNIPIHVDAASGGFIAPFTPSNTNFIWDFRLPRVQSINVSGHKFGMAPLAVGWIIWREKSHIPQCLLLESSYLRGTQSNFSLSFSRSGAPIAGQYYNFLRLGLAGFRERTHSLLDRACHLSIRLEKTGYFTCLSDAHRRQIPGVCHDLCRGSGQNTAPVLPVVVFRLTDHVKQLYPKMQLSDLSDAMHGFRFSIPNYTLRGWGYHGEDIEVMRLVLRDEMTMEMMGKVFTCITQAFERLIDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PG06</accession>
    <name>A0A0G4PG06_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S014g000149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PG06"/>
    <dbReference type="STRING" id="1429867.A0A0G4PG06"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF128">
        <property type="entry name" value="ACYLTRANSFERASE 3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="421"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="35"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL25253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="481" mass="55352" checksum="477D994A79462F30" modified="2015-09-16" version="1">MEYIQPNHIYSRILDNIPWKSADPSVKGDPRKSVKWIDGLRGIASFLVILTHLARAWDYDLFAPRDDVDTPPRILQWPVFRIPWQGRLGVTIFAFLTGYVCALKPLKQSRNGDILGSFTSVGKSAFRRPPRLIFPATIALLISWVMAQFGAFIAANRSDCWWCRYAAVDLAPTFWEEFVRLFKTFLEVWTTGYMAYDDHQWALLPLLQASMLIYVLICATMFCKFRFRVAIYLGMYLYFHQNAAKNTETFQMQAIYGMFLSDLSYENGFKEFVERHSWGRKIVAGLLLCLGLLICSYPGEHPEWATWSTYMEQASHYIFPPKVNVGRRYSALGVDLIIFAIYISPSTKEFLSSRLLLWLGKQSFAVYLVHGTLLRTVLCWMLYGITGQPWDGDIVDEKGNPIYGEDGEPLHPHWIPIRAPWVVAISIPTWIALVYFCATLWTGYVDPFCARMAQKLEKWMFEESEQAPPQLPMTSIPMPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PI42</accession>
    <name>A0A0G4PI42_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S016g000280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793149">
        <property type="protein sequence ID" value="CRL25999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PI42"/>
    <dbReference type="STRING" id="1429867.A0A0G4PI42"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL25999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="75" mass="8591" checksum="34DB9148B24DBEB1" modified="2015-09-16" version="1">MEKSPEKLLNVVRDIWANIPPVEIELRDAIISKISYHADGFVNHDEGIRILKAMPELAIAVLKETVNENTRLKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PIK1</accession>
    <name>A0A0G4PIK1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate dehydrogenase assembly factor 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S017g000238</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDHAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793150">
        <property type="protein sequence ID" value="CRL26255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PIK1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PIK1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012875">
        <property type="entry name" value="SDHF4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524:SF3">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07896">
        <property type="entry name" value="DUF1674"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="63"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL26255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="139" mass="15164" checksum="3F56E1F7EA8711A4" modified="2015-09-16" version="1">MVYSLVIRRSILSATTARGAIRPLSTTRFLRQSGDDKPMPFSDSPAPPRLPKEEQEIFEQLQKRSTGAFSTPQVNQSPQAEIQADGKGGELHPDAPKGLKPEFEGEKNPKTGEVGGPKNEPLRWGAGGDWSYGGRVTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PIW7</accession>
    <name>A0A0G4PIW7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S018g000007</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PIW7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PIW7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046623">
        <property type="entry name" value="DUF6536"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395:SF1">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20163">
        <property type="entry name" value="DUF6536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="431"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="538"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="595"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6536" evidence="3">
        <location>
            <begin position="48"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL26314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="692" mass="76453" checksum="C1713F6B8513BD65" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJE2</accession>
    <name>A0A0G4PJE2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase S26A, signal peptidase I, serine active site</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S018g000147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJE2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJE2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052900">
        <property type="entry name" value="Phospholipid_Metab_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606:SF2">
        <property type="entry name" value="ALKALINE PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G03860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase metallophosphatase" evidence="2">
        <location>
            <begin position="260"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL26454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="658" mass="73840" checksum="C36D31037B6F8FAC" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PK12</accession>
    <name>A0A0G4PK12_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S019g000179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PK12"/>
    <dbReference type="STRING" id="1429867.A0A0G4PK12"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL26762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="488" mass="53253" checksum="1C2ADB8494325C3B" modified="2015-09-16" version="1">MSTEQPTPDRPALGESWVIASTASLKENEDPTKTPNVRHESSKATTKTIDPASQSLTSSSSSSWTISGPELIMPSICETPNVEGSWVEYVRSPKQQGSESMRKRRKVSMPNSAKQREKDRTSAKAGDADAGSSAETTAKQAGLVVKSKSIFRGHTALVRKAINAVLIAIILHLLVLPEVVYQAKDLCQIPSIKTLYPSSCITFPTTYPPRSTFHPSATPPEETLATSQRQLESIFDTALETLTPLSAILKQSERMLADLESQLKSTFPDARNALDLEFTGSNQAVQTAVWEFDSLRADLRSAIDSLLASRPTTEISGTAALDTRLAIQMRRREEYLDRLRSQIRSKADSLNTRFTTLDDHLEAVDGIVAREERRSPTFHKYRPSSDDSSSDRLYSVLDSLPLGPFGAYLFRGRSSGDADANTVALTESSSSAVASTASTEPTHTPRPAATLALLRVAATHHRPVADSVLRLSRQLRDVRRATGAGSTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKU4</accession>
    <name>A0A0G4PKU4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein CSN12 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S020g000128</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN12 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793153">
        <property type="protein sequence ID" value="CRL26969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKU4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PKU4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000366">
        <property type="entry name" value="COP9 signalosome complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF0">
        <property type="entry name" value="PCI DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="247"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00073854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL26969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="454" mass="50840" checksum="40AA43EB0E5907FF" modified="2015-09-16" version="1">MTSLATAFKNAYLNGSGPELAAVLTPIAPPEDRNRLRDFYRFSNAEYISKDLSYALFHGKSLKLPKAEQAAWVDIFVVYWEAIGEILQCEDRLPGASVITVFNAWKKVANALIRGYSGSAGIPAWTLPCLYTVGKYLRTFAINADLEAASQGSAGFGFQDDIAADVEKNANLEEAARVINRMFTLCLSDRAPLEESRKWGIYNMTNLLFKTYFKINSVGLTKNLLRAIKASSADLPPPEVFPKSHIVTFEYYVGVIHFLDENYTEAEEHLTWAWKMCHRDAIKNRELILTYLIPCHLVTTHTLPSKELLAPFPRLEKLFRSLSNCIRKGDLVGFDQAMSDGEEEFVKRRIYLPLERGRDIALRNLFRKVFLAGGFDEAKEGQSPVRRTRVHVNEFAAALRVGTSTSGRSRVDIDEVECLLSNLIYKGLMKGYIARDRGIIVLSKGGSAFPGTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PL15</accession>
    <name>A0A0G4PL15_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Molecular chaperone, heat shock protein, Hsp40, DnaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S021g000035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793154">
        <property type="protein sequence ID" value="CRL27120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PL15"/>
    <dbReference type="STRING" id="1429867.A0A0G4PL15"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="11"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL27120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="224" mass="24664" checksum="2999FD68E4AFD42B" modified="2015-09-16" version="1">MSSINSRPGPNYYKTLGITQDATQQQIRTAYKRESLKSHPDRVPIDSPERPSRTRKFQEINDAYYTLSDPTRRREYDATRAYQAAEEEAEAEVPPTGAGGFPWSSFGFGGNRDDRDNDQFGSVFEEMLREEGLAEENEGEGGRRTRPTGRFWSLVGGVSGGAMGFIVGNLPGALAGAVAGNRLGAVRDAKGKSVYEVFLDLPTQDRTRLLSELAAKVFQSTMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PLH7</accession>
    <name>A0A0G4PLH7_PENC3</name>
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        <submittedName>
            <fullName evidence="6">Peptidoglycan-binding Lysin subgroup</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S021g000200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793154">
        <property type="protein sequence ID" value="CRL27285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PLH7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018371">
        <property type="entry name" value="Chitin-binding_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053214">
        <property type="entry name" value="LysM12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057277">
        <property type="entry name" value="LysM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700:SF2">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700">
        <property type="entry name" value="V CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25139">
        <property type="entry name" value="LysM14_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00026">
        <property type="entry name" value="CHIT_BIND_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195653" evidence="4">
        <location>
            <begin position="26"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="5">
        <location>
            <begin position="41"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="161"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="162"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL27285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="383" mass="40065" checksum="655F8C3E9DAC9199" modified="2015-09-16" version="1">MGFFCLGNFIALIGILLVGPTATSGAAVAVAPKADSNGLCYKYVVQAGETCSVIAQAHSITTADIETYNARSWAWAGCGQISQGSFICLSSGEPPMPVALPNAICGPQVPGTARPNSWSDLGSLNPCAANECCSSSGLCGTTSDFCTSAVHATTALSISTGTNSATSKKAPTSKQSPTSTSTTKSIHQHVASTETSSTSKAKSTSTTKSVPKSTSTTTTAKTTSTHKTTTTSTKSTQTKAKPTTSIGTSTGTTKSTPINPWILRMYTEKECAGDYYILQGYNVGYSKTCANLRGGLRSKYTETGVSCKWFTNRGKSTSDCNASTLDKPQSWIMEAGLCTVFDTKNCKSSLYSNAYTPDPKAPCQNRGKFDTPTFTSMNCYSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PLT6</accession>
    <name>A0A0G4PLT6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Increased loss of mitochondrial DNA protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S021g000058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793154">
        <property type="protein sequence ID" value="CRL27143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PLT6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018815">
        <property type="entry name" value="Incr_loss_mito_DNA_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28029">
        <property type="entry name" value="PROTEIN ILM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28029:SF1">
        <property type="entry name" value="PROTEIN ILM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10311">
        <property type="entry name" value="Ilm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195667" evidence="2">
        <location>
            <begin position="28"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL27143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="210" mass="23934" checksum="5E9C5B81E670783E" modified="2015-09-16" version="1">MVLISSKTLIQAHAVFLVVIAGYLVKSPEVITDCDLVFMMGEALKIDFPSLSSPQQSPFTFCAILIFIEALVDLVLLSNIPYHEALDEALPYIRPLRNGNLPAEDLQVLQRLPEYITKSLTIYWSVWIAVAACRFGAYAGIAFFIYQSRDDHLASSYTSAAAIGGLDRLKNRVVFSFAFFEMMFWFWNFATLREERQERLTKLLEDTREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMH3</accession>
    <name>A0A0G4PMH3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S022g000021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793155">
        <property type="protein sequence ID" value="CRL27341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PMH3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL27341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="102" mass="11395" checksum="E81288D3ADB71261" modified="2015-09-16" version="1">MSNFVVDGGSIMNGRIANIGDKSRQRLKQNNWRPDVGESGSHDQNCCIVAHFSLQVESIGKGAEDPASFRQMNHVNISPDAKFANRDMSKDEFLEYFCGRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMM4</accession>
    <name>A0A0G4PMM4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S023g000067</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793156">
        <property type="protein sequence ID" value="CRL27609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PMM4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PMM4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Dupont J."/>
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            <dbReference type="PubMed" id="24407037"/>
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    </dbReference>
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    </dbReference>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Dupont J."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL12M"/>
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    </dbReference>
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        <source>
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    <sequence length="191" mass="20135" checksum="62168ABEF16208E4" modified="2015-09-16" version="1">MSFSTQAAARCARQLSGSVRPSSLRIATSATYLTARRTPSSRRCESTQAAPAAATNPKISQIVDQISTLTLLETADLVSSLKTRLNIPDLPVGGFAMAAGGAPGAAAAVEEEEAAPAAAEKTLFNLKLESFEPTSKPKVIKEIKTMLGLSLVDSKKFVESAPKILKESVPKEEAEKLIETFKALGAKATME</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
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        </lineage>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Dupont J."/>
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                <person name="Abraham A.L."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793157">
        <property type="protein sequence ID" value="CRL27927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PNC8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PNC8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080122">
        <property type="term" value="F:AMP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005347">
        <property type="term" value="F:ATP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015228">
        <property type="term" value="F:coenzyme A transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015230">
        <property type="term" value="F:FAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044610">
        <property type="term" value="F:FMN transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051724">
        <property type="term" value="F:NAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000134">
        <property type="entry name" value="Peroxisomal membrane protein PMP47B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF5">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="18"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="118"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="223"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL27927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="317" mass="34494" checksum="86896A673AB7EA1B" modified="2015-09-16" version="1">MSQAGAESKAASAAVQQSDNIAHALAGAGGGVLSMVLTYPLITLSTRAQVESKRAHSTTLDAVRRIVQREGISGLYSGLESALFGISVTNFVYYYWYEFTRSAFEKAAIQGGRASKKLTTVESMIAGAIAGSATVLITNPIWVINTRMTARKSEAEETLPGAKKTKASTLSTLMDLLRQEGPKALFAGVLPALILVINPILQYTIFEQLKNMVERRRRMTPKDAFYLGALGKIMATSLTYPYITIKSRAHVASRDGPKESLNGSLKRIIREEGWKGLYKGIGPKVTQSAITAAFLFAFKDVLYDMMVSARRKGRIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNW3</accession>
    <name>A0A0G4PNW3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Polyprenyl synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S025g000118</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793158">
        <property type="protein sequence ID" value="CRL28060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PNW3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PNW3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045337">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000006">
        <property type="entry name" value="Farnesyl pyrophosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01017">
        <property type="entry name" value="Polyprenyl_Transferase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL28060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="347" mass="39824" checksum="5E5CBE2E56F1215F" modified="2015-09-16" version="1">MVSTTKRADFEAIFPALAQDILAHAKRYNLPDNALEWFEKSLNVNVPGGKLNRGLSVPDTGLALLKQPLTEEQFEHLSILGWMTELLQAFFLVSDDMMDSSITRRGQPCWYRHEGVGQIAINDAFMLEAGIYLILKQRFRSHPAYIDIVELFHETTWQTELGQLCDLITAPEDNVNLDNFSMEKYMFIVTYKTAYYSFYLPVALALMYLELATEENLKQAHDILIPLGQYFQIQDDYLDNFGDPSVIGKIGTDIQDNKCSWLVNQAIQRCTPEQRQLLDASYGRKDAAEEAKVKALFNELQLEKVYKEYEEKVVGELREKIAAVDESKGLKKEVFEAFLGKIYKRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPF7</accession>
    <name>A0A0G4PPF7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DeoxyUTP pyrophosphatase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S026g000140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793159">
        <property type="protein sequence ID" value="CRL28275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PPF7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008829">
        <property type="term" value="F:dCTP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006229">
        <property type="term" value="P:dUTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011962">
        <property type="entry name" value="dCTP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42680">
        <property type="entry name" value="DCTP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42680:SF3">
        <property type="entry name" value="DCTP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22769">
        <property type="entry name" value="DCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL28275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="170" mass="18806" checksum="BBBFF09951DB5CEB" modified="2015-09-16" version="1">MILPGRSLITRSIIRNVKYPTLQAQPCGVDLTLKRVLKWTSPGIIDLDNQLRQPASTEEIPFPLSNENTKPYLDLVQGSYLVEFNESVSVPLDVMGEIFVRSSLFRSGVTIHAGVMDSGYEGAVGALMQVVNPTGLRLYPAARLAQFVFHQMSEKVEGYNGIYQGMTSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPW4</accession>
    <name>A0A0G4PPW4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S028g000020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793161">
        <property type="protein sequence ID" value="CRL28467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PPW4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL28467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="70" mass="7397" checksum="F29DD819D02A663D" modified="2015-09-16" version="1">MPLAPISTVISTEHATSKISAPNHPISNLGKHSITTRRSPGTLHQEVPILSASDGDALSWEGIDMGIEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPX0</accession>
    <name>A0A0G4PPX0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide-like helical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S026g000138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793159">
        <property type="protein sequence ID" value="CRL28273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PPX0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PPX0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052769">
        <property type="entry name" value="TPR_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL28273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="303" mass="33562" checksum="A826E682AC21B81B" modified="2015-09-16" version="1">MSSPSNAPEREGKGTPNDADDSGDEDVFHDAHFPAEEEAQLLKEAHEIKSEANQLFLATSYDQAISCYDRALASCPSYLDYDVAIIHSNIAACHLKLEDWKAAVDSATVSIERLSKIIPPTTQDKSDESKGKQIPESEKKHTDAVVELSGDDEEAELKELQRLQEQDEQRSKVMRLRAKVLMRRAKAKTQIGGWGSLQGAAEDYQALAAIENLPADDKRVVQRALRELPERINQAREKEMGDMMGKLKDVSTFFPGNICIKMIGNTDIGQLGNGILSPFGLSTDNFKFVQDPKTGGYNMNFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQ05</accession>
    <name>A0A0G4PQ05_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosome recycling factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S027g000119</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Necessary for protein synthesis in mitochondria. Functions as a ribosome recycling factor in mitochondria.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRF family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793160">
        <property type="protein sequence ID" value="CRL28430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQ05"/>
    <dbReference type="STRING" id="1429867.A0A0G4PQ05"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.40:FF:000020">
        <property type="entry name" value="Similar to ribosome recycling factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="entry name" value="Ribosome-recycling factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982:SF3">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME RECYCLING FACTOR PSEUDO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="RIBOSOME RECYCLING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="Ribosome recycling factor, RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome recycling factor" evidence="5">
        <location>
            <begin position="97"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="40"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="224"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL28430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="269" mass="29692" checksum="E103C1A3918D87B4" modified="2015-09-16" version="1">MQRIITQSIRSFYPRIVARPQGTQAFRPLCLLPRTQRATPLNRREFANSPALHKKKDKAKKASSSASEPEESSSAPSEDPFDLSQLHNGISTAIARLKDDLSKLRAGGRFNTTVLESLRVQLSKDSKDSAKLGDLAQVVPKGGRMVTLLAAEEDHLKPLTSAIVSSNLSLTPQPDPHNALQLNIPIPPPTKESRDKNVQAAKQAFEKAAGVVRDSRGAMHKRLQDMQKKKLARPDDVRKAHDQMEKVTEQGQKEVKDAFEAAKKTLEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQ88</accession>
    <name>A0A0G4PQ88_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">L-dopachrome isomerase</fullName>
            <ecNumber evidence="9">5.3.2.1</ecNumber>
            <ecNumber evidence="8">5.3.3.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">L-dopachrome tautomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phenylpyruvate tautomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S028g000093</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-phenylpyruvate = enol-phenylpyruvate</text>
            <dbReference type="Rhea" id="RHEA:17097"/>
            <dbReference type="ChEBI" id="CHEBI:16815"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="EC" id="5.3.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-dopachrome = 5,6-dihydroxyindole-2-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13041"/>
            <dbReference type="ChEBI" id="CHEBI:16875"/>
            <dbReference type="ChEBI" id="CHEBI:57509"/>
            <dbReference type="EC" id="5.3.3.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.2.1" evidence="9"/>
    <dbReference type="EC" id="5.3.3.12" evidence="8"/>
    <dbReference type="EMBL" id="HG793161">
        <property type="protein sequence ID" value="CRL28540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PQ88"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004167">
        <property type="term" value="F:dopachrome isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050178">
        <property type="term" value="F:phenylpyruvate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001398">
        <property type="entry name" value="Macrophage_inhib_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954">
        <property type="entry name" value="D-DOPACHROME DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954:SF6">
        <property type="entry name" value="MACROPHAGE MIGRATION INHIBITORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01187">
        <property type="entry name" value="MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="Tautomerase/MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="287"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="306"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CRL28540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="370" mass="40620" checksum="88A97B3EBB648AF0" modified="2015-09-16" version="1">MDHSKKKPSLPRLTTNIPLLQKPPNASCNAIPNPLDASAPPIIMPERPARTSSMFKEEKHDKENIAPATRFASESMPIYLSQKSVDDSPLTKVKKLYYEDAFTARGSHNSPKDRITHESVVVVELKTNTKAKDDTPKLLSDFAHFLAQIYQRPETSMLVTIDQNADLLFGNTSGSAYLLKITALSSLIGPLTNLRNTGLIQSTIQEMFGIAPDKGVLIYTPASEDNLATNGMTARSEIDRLERIDSSNNPSILKSISRSMSRRMKSSSGNSASISLTSVMSPDVASPISTSPVALASGQAPPPKPHQTDEKEPMESPKRESIKQVSSKEEKCERTLKKRESLKSFVNRRLGELGELTTKKPFTATKGKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRF1</accession>
    <name>A0A0G4PRF1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S029g000107</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793162">
        <property type="protein sequence ID" value="CRL28691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PRF1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PRF1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL28691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="360" mass="39341" checksum="30404BB2A33A6D8E" modified="2015-09-16" version="1">MDAGNMSSQQQHQQQLIQNARRHRMQMITAKRQSNTLSGQQMQPQSGTMGSKYDDLPMLEPADIIFIGENPKSVGLVPAFFGPFESACQHGPLSIIQSIVSSKNLTPAFLHHGLTRALRSGNIEVVRYLLASGAPIVRETPSNIFFVTLEQQIALFELFTQHGWTPNTPGYYGSTLLPRTVNSLPLLRWFIDHGANPNLGVQKTTHDRRGGPDTSSCAALEAAAVRGGVEAVRMILDAGAKIQNGVPLHYAAGARPPGANPHAGRVVPSREFDTGRIPVMALLVDRGADVNQREESRHMVPQYAIVHAVMAGAVERVKWLLEHGADPYIRGSWGSAAEYARTSGNEEIIKVIEELATEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PSX8</accession>
    <name>A0A0G4PSX8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin-like fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S037g000056</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793170">
        <property type="protein sequence ID" value="CRL29569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PSX8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PSX8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047134">
        <property type="term" value="F:protein-disulfide reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045108">
        <property type="entry name" value="TXNDC17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010357">
        <property type="entry name" value="TXNDC17_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452">
        <property type="entry name" value="42-9-9 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452:SF0">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06110">
        <property type="entry name" value="TXD17-like_Trx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="20"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL29569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="125" mass="13974" checksum="B79D26AE3B268851" modified="2015-09-16" version="1">MPITTNFTLPSSAKELALSPDSKLFIAFISSPDPITKQPWCPDVRDALPHINKAFSGDDAPELAIIEVGQKPEWSNPRNVYRTTWGTNNIPALVRYEQVNGKVAETGRLVEAEILNKKRLREFIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PT69</accession>
    <name>A0A0G4PT69_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bacterial extracellular solute-binding, family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S037g000084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793170">
        <property type="protein sequence ID" value="CRL29597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PT69"/>
    <dbReference type="STRING" id="1429867.A0A0G4PT69"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30006:SF2">
        <property type="entry name" value="ABC TRANSPORTER SUBSTRATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30006">
        <property type="entry name" value="THIAMINE-BINDING PERIPLASMIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13343">
        <property type="entry name" value="SBP_bac_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195951" evidence="2">
        <location>
            <begin position="22"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL29597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="368" mass="41551" checksum="5F1272C2E6A186F2" modified="2015-09-16" version="1">MKIAGQQLILGLLGLVDLARCNVLPNWNSYPSHDPAIENRTLDEIYAAAKKETGDLIVLWGGDAVSQGDATIEAWQKRFPDIKLNLTVDVSKYHDSRVNRQFQRNGTDGADIAVLQTLHDFGHWKREGRLLPYKPLKWEDIYTAVKDPQGAFVGAFIYQFGDLIYNTGLLNESKVPSSYGDFVRPEWKSKLTLTYPNDDDAITYLFSVIIGKYGWEWFESLVEQDVQWVRGTGEPGNYVAETNSTRSLSFTTNLNGANNLASKTPEEAALLWPQTGAIFASTSRPESAKLFMSWLLSDERQQGSGSYLVRKDLSSKLESVWDDKFTALTQFATFMENRELVEWWRLQFETSIGSAQGPSPVHSYYGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PTW1</accession>
    <name>A0A0G4PTW1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S038g000001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793171">
        <property type="protein sequence ID" value="CRL29598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PTW1"/>
    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="353"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL29598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="686" mass="76307" checksum="07D40B1BE8C250E5" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUI6</accession>
    <name>A0A0G4PUI6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S043g000058</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793176">
        <property type="protein sequence ID" value="CRL30063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PUI6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PUI6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL30063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="161" mass="18222" checksum="8F07356EB4839E0D" modified="2015-09-16" version="1">MKSTILNIARKYILLPRSQAVPNNDLPANIGRHAKRVDAALPGKHTRQLYDRLSWKEASVLAQLRTGMARLNGYLYRINVADTDQCACGQARETVEHFLFRCQKWTAHRMELLQCTNTHRGNISFFLGGKSPSDDQKWTPNLEAVRASIRFAIATGRLEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUQ7</accession>
    <name>A0A0G4PUQ7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S041g000006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793174">
        <property type="protein sequence ID" value="CRL29864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PUQ7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL29864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="57" mass="6561" checksum="D38C5B86ED52FAA8" modified="2015-09-16" version="1">MQMSRLLNDIGDFIKNREDLVQSDQPEREKTPANQEGPRNATQDDDTPMKTSEIQDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUV3</accession>
    <name>A0A0G4PUV3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HIRA-interacting protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S041g000056</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793174">
        <property type="protein sequence ID" value="CRL29914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PUV3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PUV3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000001">
        <property type="entry name" value="NFU1 iron-sulfur cluster scaffold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.70:FF:000001">
        <property type="entry name" value="NifU-like protein 4, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.70">
        <property type="entry name" value="Scaffold protein Nfu/NifU, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014824">
        <property type="entry name" value="Nfu/NifU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036498">
        <property type="entry name" value="Nfu/NifU_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035433">
        <property type="entry name" value="NFU1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178">
        <property type="entry name" value="IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178:SF1">
        <property type="entry name" value="NFU1 IRON-SULFUR CLUSTER SCAFFOLD HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08712">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036773">
        <property type="entry name" value="HIRIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00932">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110836">
        <property type="entry name" value="Hypothetical protein SAV1430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scaffold protein Nfu/NifU N-terminal" evidence="3">
        <location>
            <begin position="86"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL29914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="320" mass="35138" checksum="1F26D1E8309128E2" modified="2015-09-16" version="1">MSLSTPSTTMFRRALLSSRLATPVECSARTIRPAFARYRYVSSAARLPTITASETRRRPTVRPHQQPASQGGVNGLSPTSKRTIFIQTENTPNPDALKFIPNHRVLPEDFPSTFLEYMSPRSTLAPPHPSPLAAKLLDVEGVTSVFYGTDFITVTKGSDANWAHIKPEVFSIITQAVTSGETIVTTVEGAIDGEQESGEDSLSYNEDDDEVVSMIKELLETRIRPAIQEDGGDIELKGFEDGIVMLKLRGACRTCDSSTVTLKNGIESMLMHYIEEVKGVEQAMDEEEIISMHEFSKFEEKLRQQKGAAATANAPLDSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUZ1</accession>
    <name>A0A0G4PUZ1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S042g000018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793175">
        <property type="protein sequence ID" value="CRL29959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PUZ1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL29959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="57" mass="6309" checksum="03B26D728EBE8898" modified="2015-09-16" version="1">MHEICKDLSPSSQCDLSTDQQGHPRYPSSCSPELKDFSNRSPLPSYSKNTSAAHVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PV21</accession>
    <name>A0A0G4PV21_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase superfamily, zinc-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S042g000041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793175">
        <property type="protein sequence ID" value="CRL29982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PV21"/>
    <dbReference type="STRING" id="1429867.A0A0G4PV21"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08241">
        <property type="entry name" value="QOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF4">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="12"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL29982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="341" mass="36432" checksum="1EC98295788BBD29" modified="2015-09-16" version="1">MRAVQVSEYVKGPLDLKVTTVPTPTPTADKYLIEIHSAGTNFFDILQIQGKYQNQPPLPWIGGAEFAGTVIAVPTSPNNRYKLGDRVFGATQGAYATHVLAAEQTLLPVPEGWSFEDAAGLFVTAPTSYGGLVQRAGVKAGDWVLVHAAAGGVGLAAVQIAKAMGATVIATAGTERKRQIAKEFGADYVVDYTNKAWPEIVKGICKENRKGNGAAGVDIVYDPVGMIETSLKCVAWNARLLVIGFAAGKIEKVALNRVLLKNVSIVGLHWGQYAKFETETVGEVWQGIFDLVKQGKFKGTAFKDESFVGLESVPRALQALGGRETWGKVVVNIVGDSKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVH4</accession>
    <name>A0A0G4PVH4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S050g000030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793183">
        <property type="protein sequence ID" value="CRL30383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PVH4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PVH4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03445">
        <property type="entry name" value="Thioesterase_II_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000074">
        <property type="entry name" value="Acyl-CoA thioesterase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF34">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="2">
        <location>
            <begin position="42"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="3">
        <location>
            <begin position="162"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL30383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="367" mass="40598" checksum="305F5CCB6CF42BAF" modified="2015-09-16" version="1">MSKRVTIFDPPAQDHSKALIENVLDLTPVLDLGRDVFTNTRPLWHPPGARGIYGGAAIAQSLSAAMLTVPADYAVHSMHCYFVLAGDSEIPILYHVERVRDGRSFVTRTVQARQRGRPIFTTTLSFSRVGSGGEKTIHHAVSKPDVPLPEEAEPGSLKALSNAGGGPFESRKAGILNRTSPNQEDKKVRRYIRARGAISEQGGYQAHLSALAYITDSYFIGTISLVHDIPRFSSPAELEKLLNALKNPSDLDDEDITRALRELKEEEAAELRRRLEGALNRATTGKNEADHKEVGMMVSLDHSIYFHNPRAFRADEWMLTEMESPWAGEGRGLAIQKIWSKDGLLIATCMQEGVVRLKQDKPPLSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVK3</accession>
    <name>A0A0G4PVK3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S048g000043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793181">
        <property type="protein sequence ID" value="CRL30331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PVK3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="348" mass="38254" checksum="22C9D7DF8570B7EA" modified="2015-09-16" version="1">MSTTLPWNPFLVCDIEVSPNVGPGSCCGMTKKGAPCKNSINFQDTKIGHQKLNILTRESFDISTDISTLQSKLCAIAKEFLCARWHQQRQADQLGLQVATPPIVHSRQRQTSSGSSRRPVESDNTDWPPSHGHRQDPPAPLTTSAGTVQSINHFVTAEMLRTNSVSWHVSPTRPAILTSVTNIWAGVQDLSLQNLSLSEDVNEIHCVFCLAEDEDQATERVILRCGQCRAQAHLCCAEEWLGKRRTGFGTSCCVCRNEGSLDALIRPIRVPSASEPSANRETVTVRNSAPNEPRQNQLPQRSMGSPRVSVEQSGLRRSARVAGAHLPRDPSTSAPLRRSARLNPTQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PWN5</accession>
    <name>A0A0G4PWN5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S055g000015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793188">
        <property type="protein sequence ID" value="CRL30600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PWN5"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF2">
        <property type="entry name" value="LYTIC POLYSACCHARIDE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195677" evidence="2">
        <location>
            <begin position="20"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL30600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="410" mass="41702" checksum="2E7C27DF09092264" modified="2015-09-16" version="1">MFITSKVIAALMGASMVNAHMIMSSPTPYSKDSLNNSPLAADGSDFPCKLRDNAFEAPSTETIIAIGESHPLSFIGSATHGGGSCQISLTTDLTPSKSSEWKVIKSFEGGCPANVDGNMAGGPDVTDPYSFNFTIPDGISAGKYTLAWTWFNRIGNREMYMNCAPITVSGGSSKRSPEELERRAASFPPMFVANVNGCTTPDSVDIRFPQPGDIVEYDGEAANLAKEGSEACTGTASFGGSGDTTSSSSSSGSDSGSSSSGSASPASSSAPAESASTAPATVSAAPVPEATPSSSPAETEPEPTSSSAAAPAPVTTSSSGSESASSSSSSSAALTGSCSTEGQWNCISGTSFQRCSSGTWSVAQQMSTGTQCNAGQSAELVVTASRKARHVSSMRFRNRAFGAHHAHALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PX30</accession>
    <name>A0A0G4PX30_PENC3</name>
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            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
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    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
            <strain evidence="2">FM013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793194">
        <property type="protein sequence ID" value="CRL30858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG793222">
        <property type="protein sequence ID" value="CRL31219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PX30"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL31219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="79" mass="8623" checksum="7A423ABE87F5161B" modified="2015-09-16" version="1">MSLPKSAGGVQQPANETFVKSYQPLNPASISLEEYNRTMLHHTQRQISSVDKSDSDGGSGPRSRSSEHFHASNQDPSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PX61</accession>
    <name>A0A0G4PX61_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S062g000032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793195">
        <property type="protein sequence ID" value="CRL30893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195690" evidence="2">
        <location>
            <begin position="18"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL30893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="368" mass="39827" checksum="4F6357F9A4C94C0F" modified="2015-09-16" version="1">MIIPITAILALASLVPAIPVEGDIFAPTSTDGASALQGMNAATRELDARMEKISTALDIRSENPAARALMELESRDPGSREVGAPRFSAQQYTGAQAVVWYSALSATSLCAVFGGGAACTALFPFIVGIMNVVIYIGAMRNGDIPRGSRYVAGLLGTNALLIDIEMGSLTPSEESQANRLLSDAPFNSNSKRSLLEEEHLNVARLFEGSSLEFDRIELEDVSFLNQQKRSLDSPDLTHRMMIRGAKMNDLSHDLAFDRYSNGQSGISFNFNDTKFGGESELNKRDLSDVGLKVTFSYPQGQKIDKGDSLRTDLSHGIAKHWSELAFSQTGWSEYLGSILDSDRNSVVKYRIQVTKGEPSSSPGDLSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PXA3</accession>
    <name>A0A0G4PXA3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S077g000009</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793209">
        <property type="protein sequence ID" value="CRL31128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PXA3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PXA3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046541">
        <property type="entry name" value="DUF6606"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20255">
        <property type="entry name" value="DUF6606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6606" evidence="1">
        <location>
            <begin position="18"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL31128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="879" mass="102217" checksum="BD65739F2B59224E" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PXA5</accession>
    <name>A0A0G4PXA5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase, RNA-dependent DNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S064g000017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793197">
        <property type="protein sequence ID" value="CRL30943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PXA5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PXA5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="129"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL30943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="386" mass="44056" checksum="21DC4E82069809C7" modified="2015-09-16" version="1">MKKERYPNDNRPPDRLIYEHINLYEGHLNTPRDSLAAKNWWAVLEAVAGSKKGKYLKLFFKHETLHQKLNSLLVIPGLWEGMRIGLLHKVTAMHCDEPIACYWGLIFSTFSRLVGGRDELLPLVDGVTVELIHAVLRGWKLHQFDVVIAFSHGDIDSSICMELPEGFEEPGYVCRLYRSLYGLKQAPRIWYQCVHRVLAAHGFTMAQSDNCVFYKSNCVICVYVDDFLVAAANSHKIEQVQRALQTEIQLNDLGTPRSFLGIQFDYHADGDKEAKARFATAIGLLIYLIIGTRPDIAFALIALQRLLRYIKAIQSRYMTYRNRQLIGYTDADFRGSVVTDSAYSTSSYVFQLTGALVSWSSKRQGEVARSMIYTEYIGQYKAILYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PXL8</accession>
    <name>A0A0G4PXL8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S081g000005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793212">
        <property type="protein sequence ID" value="CRL31146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PXL8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL31146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="409" mass="45922" checksum="89865E98B445E308" modified="2015-09-16" version="1">MFAVRIARSYPITTVQFLVTGGFVARLWGSEVARCIRRGFFEVTAGECNELDTTSYQHGMNGDCIAEDDWGTVMFPLLKSKRASALSARAPRYRCDPMLYHPEMTIGGIDDEPMPCADASTRYIREIPMAYTTVCLSAFEHGAEKCRCLVLHNDRGFLPSPLAMLLVQIRVQGEATNREDKAVYTEAQPSQLKSQKYRPILSHLVPRVAQAFDTYERVEMNQAEIYGATSSRSQKCLLGTGAWCIWIPSTHFSIKAQQLSRKSYMLWMSLKLQVTKLAARLCLLMSFSNLSRKQLLPGASSDSVHQRRHPFSIKYIFQSKLDRMNPGTTPRKATTGGSDAVLDIDTWANKWYFEWFLINASMPDGKKTSVLRLGILIDLDSAHEAHGFAMTYFHLSMGGHGVGWPMAAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PXS8</accession>
    <name>A0A0G4PXS8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S086g000003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793217">
        <property type="protein sequence ID" value="CRL31202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PXS8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL31202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="67" mass="8188" checksum="DA983719B227632D" modified="2015-09-16" version="1">MERCAFLPLPDDPLLTPPLLKRVGPDRRKGFILYDIMSYNDFVDWWLETDYRRKSKLKWDSNYHIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PY59</accession>
    <name>A0A0G4PY59_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S3Jg000019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793312">
        <property type="protein sequence ID" value="CRL31408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PY59"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL31408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="348" mass="38588" checksum="82CE84DB18E22CF3" modified="2015-09-16" version="1">MALSGLHLARNWMQAGVGVLRGIAHSMYHDGNSSSGSSTYPLVGVPIDYPYGLTPAPLMDSAPAVDQASDVCWSFEQAQNWTITRASPTVTLSPLPISRYREIRPRPLHESASTLPPVQPGKEEQHSQYRKLGRRKHSKSHRQSDQGYLKKTARSAIRTASEVTDTTKKQVRVGRMSRAKPPKAPGGDSATQGPRRRSPDCSSNHPGDSPQASVGALQRALKAQVLQSLEVLREIAKEFRAFNLGLETIDDWVAEIKEVDETLIPVPSSTAVLQVHVPFEKLSFILTKCITASGRMRDFIVRDQALELLKYIQTYAEEYHLFKNLRVHLDIDSTAAILLFQTFPPPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PYJ7</accession>
    <name>A0A0G4PYJ7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hly-III related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S103g000001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793234">
        <property type="protein sequence ID" value="CRL31279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PYJ7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PYJ7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL31279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="252" mass="27836" checksum="74938A5E92D3B973" modified="2015-09-16" version="1">MRIHETVQSIDNLSAMADPDVQSMRDCVVLSIINAFGLFYFYLFTIHFLLFHFPSSPAEILVAMSVLVFCAGVIVWYFLSLVYRILHTFQGNDSGNLQKLEFGGALILIWTATIPSAVLLLRNQPSLQLGYLSAFTIVAVGTLVDFLVWGSSIHASRSIFPYACVSLGLLSLIPSIHALTGTFESPPSLAIHFGRVAMWNSLGAAFYLLRPLERVGAVNDWRPSLYVMHIVLAYSAVSYSRVILHTVLGYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PYN6</accession>
    <name>A0A0G4PYN6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ATPase, AAA+ type, core</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S117g000004</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793248">
        <property type="protein sequence ID" value="CRL31320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PYN6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PYN6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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            <dbReference type="PubMed" id="24407037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
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            <dbReference type="EMBL" id="CRL17260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="574" mass="63769" checksum="D92D057DDFD22E51" modified="2015-09-16" version="1"> </sequence>
</entry>
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    <accession>A0A0G4NTM8</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        </location>
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        <location>
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            <end position="559"/>
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        <location>
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            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="308"/>
        </location>
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        <location>
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            <end position="386"/>
        </location>
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        <location>
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            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL17455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="559" mass="61969" checksum="F0D917F672896CF3" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NUI5</accession>
    <name>A0A0G4NUI5_PENC3</name>
    <protein>
        <submittedName>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NUI5"/>
    <dbReference type="STRING" id="1429867.A0A0G4NUI5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL17716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="364" mass="41604" checksum="9F93756E39E95E33" modified="2015-09-16" version="1">MSVSASLSPLELLPNELLDQIIAYLTTEPPSFGKLHNTPSLELTQSPTKDLKHLELCSRCLFQLVRPQLFTHVRLSLHDEPDFHSFMVKSGLGQYVTSLVAIADETPDCQVNPLWWRRVLRYLDPRRILVIGPPVFIGNTLDSPINDGHHWAFDMPLQILLLERECKPRDPSQLPDLENCTSLLASRPWTSMTFNESSSLKAYNHYEYFLSCVPSVLVEWGTRGIPGTSRELERPISLPALLRDLTYFSYTAVFPFYNHSQIVMDAVVRMHRLQRLDVQLAPPQDNHITELEQRGSMDPNDPWMELTTSYSLIGYTVNLLPCLQEFRCGDLHVEAMRQDLLAVLDDAIGDKGWVHDGRGVWRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NUM8</accession>
    <name>A0A0G4NUM8_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S001g000740</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NUM8"/>
    <dbReference type="STRING" id="1429867.A0A0G4NUM8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05581">
        <property type="entry name" value="STKc_PDK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000163">
        <property type="entry name" value="3-phosphoinositide-dependent protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000128">
        <property type="entry name" value="Serine/threonine-protein kinase ksg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039046">
        <property type="entry name" value="PDPK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF163">
        <property type="entry name" value="3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="251"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="131"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="553"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="739"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="763"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="773"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="805"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL17780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="822" mass="90177" checksum="B00FD301488398F5" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NUT2</accession>
    <name>A0A0G4NUT2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S001g000749</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NUT2"/>
    <dbReference type="STRING" id="1429867.A0A0G4NUT2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021709">
        <property type="entry name" value="DUF3292"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38694">
        <property type="entry name" value="CONSERVED EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38694:SF1">
        <property type="entry name" value="PEROXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11696">
        <property type="entry name" value="DUF3292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL17789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="638" mass="68942" checksum="AFF18E40BC6A4DB8" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NV16</accession>
    <name>A0A0G4NV16_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">glycogenin glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.186</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S001g000865</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Self-glucosylating initiator of glycogen synthesis. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = alpha-D-glucosyl-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23360"/>
            <dbReference type="Rhea" id="RHEA-COMP:14604"/>
            <dbReference type="Rhea" id="RHEA-COMP:14605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140573"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56560"/>
            <dbReference type="Rhea" id="RHEA-COMP:14606"/>
            <dbReference type="Rhea" id="RHEA-COMP:14607"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140574"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.186" evidence="10"/>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NV16"/>
    <dbReference type="STRING" id="1429867.A0A0G4NV16"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008466">
        <property type="term" value="F:glycogenin glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000092">
        <property type="entry name" value="Glycogenin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="284"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="424"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="530"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="591"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="691"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="305"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="564"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="595"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="691"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CRL17905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="714" mass="79979" checksum="C5A60FCC5EE7BF06" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWC0</accession>
    <name>A0A0G4NWC0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">RuvB-like helicase</fullName>
            <ecNumber evidence="18">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PCAMFM013_S002g000220</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="function">
        <text evidence="15">DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="17">May form heterododecamers with RVB1. Component of the SWR1 chromatin remodeling complex, the INO80 chromatin remodeling complex, and of the R2TP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="18"/>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWC0"/>
    <dbReference type="STRING" id="1429867.A0A0G4NWC0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002221">
        <property type="entry name" value="RuvB-like 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000002">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0010">Activator</keyword>
    <keyword evidence="8 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 18" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5 18" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13 18" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="12 18" id="KW-0804">Transcription</keyword>
    <keyword evidence="10 18" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="19">
        <location>
            <begin position="68"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00065373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CRL18350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="469" mass="51496" checksum="8F0F2AAC683111BE" modified="2015-09-16" version="1">MAVPISTVAEGKELRGLNLIAAHSHIRGLGVDADTLQPRTSSQGLVGQEKARKAAAVILQMVREGKIAGRAVLIAGPPSTGKTAIAMGMAQSLGPDVPFTMLAASEIFSMEMSKTEALTQAFRKSIGVRIKEESEIIEGEVVEIQIDRSVTGGNKQGKLTIKTTDMETIYDMGTKMIDSMTKERVMAGDVISIDKSSGKITKLGRSYARSRDYDAMGADTKFVQCPEGELQVRKEIVHTVSLHEIDVINSRSQGFLALFSGDTGEIRSEVRDQINTKVAEWKEEGKAEIIPGVLFIDEVHMLDIECYSYINRALEAELAPIVIMASNRGQSRIRGTTYTSPHGLPLDFLDRVVIVSTQMYSGDEIRQILAIRAQEEEIDLSPDALALLTKIGQESNLRYASNIITTSHLLSQKRKAKEVNVDDVQRSFRLFYDPARSVKFVNQYEQRFIGDQGTVSFTAATNGDAMELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NX93</accession>
    <name>A0A0G4NX93_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">T-complex 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S002g000608</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP11 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NX93"/>
    <dbReference type="STRING" id="1429867.A0A0G4NX93"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010737">
        <property type="term" value="P:protein kinase A signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008862">
        <property type="entry name" value="Tcp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832:SF11">
        <property type="entry name" value="LD23868P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832">
        <property type="entry name" value="TESTIS-SPECIFIC PROTEIN PBS13 T-COMPLEX 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05794">
        <property type="entry name" value="Tcp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL18738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="648" mass="73344" checksum="5062C395EAC60DC0" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXH9</accession>
    <name>A0A0G4NXH9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S002g000636</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NXH9"/>
    <dbReference type="STRING" id="1429867.A0A0G4NXH9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03442">
        <property type="entry name" value="BFIT_BACH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000032">
        <property type="entry name" value="Acyl-CoA thioester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000038">
        <property type="entry name" value="Acyl-CoA thioester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655:SF0">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="6">
        <location>
            <begin position="98"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="HotDog ACOT-type" evidence="6">
        <location>
            <begin position="295"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL18766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="462" mass="51178" checksum="D9E561B77B595B33" modified="2015-09-16" version="1">MFGLSRRSALARSKSLAALPARAAVAAQPSCINTQDFHSTSSQAGSRPTWMPMRVKTPWIDALTQTREAEKAGPQEKAGQNVKPDVSPKKMSDSYYSAILPLAQDKWLLDSYLNASGHIRLGSLLMDLDALAGIVAYRHTGDGVSTVTAACDRITIENPLMEICDLELSGQCTYATGRSSMEISLQVTKARPEGQEAKPEDVLITCAFTMVSLDPATKTPVPVAPLIVETEEEKRLFQKGEANYQAKKALRTRSLLEKAPDAEESNLIHSMWTKEMSYLNPQNPAIRPANQAFMSDTVLKSAMIMQPQYRNRHNFMIFGGFLLKQTFELAFCCAASFAHARPNFVALDPSTFENPVPVGSVLYLRATVAYTEPEEREGDSTKYTKVQVRVDSKVRDVEHGTKKSTGMFNYTFLVEKDVQVMPKGYGEFMLWADARRRAQNAAAIDPMHKMSALRSIKDSVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXQ7</accession>
    <name>A0A0G4NXQ7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S002g000639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NXQ7"/>
    <dbReference type="STRING" id="1429867.A0A0G4NXQ7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL18769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="217" mass="23537" checksum="4431D207DF713D2C" modified="2015-09-16" version="1">MTAPRSSSLRALRTLFQQPVAPSTRRSLHITGVQSAQPANNGEKALSNHDVLQSRAFSIAMRRINGNAFSDSSSSRQFNTSRATKALNDTSTVDFVYMPTMADLDAAPLQRSIQVPVLPELPSLPWRQTPTAPPMKPQIYTVSGTGADVSASAMSEVVDNHAIDLDPFSLTEAVGRSRAGEETQRRSNGSSEPGVIRELWAGFLDDVMGPKETVQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXV5</accession>
    <name>A0A0G4NXV5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S002g000788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NXV5"/>
    <dbReference type="STRING" id="1429867.A0A0G4NXV5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL18918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="418" mass="46342" checksum="6DFD5CBCAA941BCF" modified="2015-09-16" version="1">MSDQGGVFGAFGAVLGYIGAEAATDIWFMSLLWPQRSFSYLTLRSIPTLALLMPMGGPLHKAALSTFDIANARGLLKGAHEGHMLGTSFFEQTDWTYTMPGTASSEPRAARNCMWARALHYMPLPAENLGSLAGISPPATGNAIEKGILPTADNGRIPLRAKVAVYHLIFTPATAEDKASQMAFVHENCGRPGWHVYLCIFIAELSGIILFAVIYAIGRSLWCLIWLAPLLLRFLSAFFALDREPLTPISSSNSPPSSTPTTEAESPRDFVLEFPQSQGGDLMLFTGLSALVQQFFRHYGHPVRNRTREILQMCIISLFAALFPLGLLASTLWMPPLVQYAWICYQLYIVMTMHIVRYTSFGRDTSTECKIADYLADRPEILFGVKRNGAETVKVSLIATYHARHQEGRDCLERLVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYI9</accession>
    <name>A0A0G4NYI9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL39</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L39</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S002g000996</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL39 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL19126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NYI9"/>
    <dbReference type="STRING" id="1429867.A0A0G4NYI9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1620.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein-like L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.10">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00629">
        <property type="entry name" value="Ribosomal_eL39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000077">
        <property type="entry name" value="Ribosomal_eL39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023626">
        <property type="entry name" value="Ribosomal_eL39_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19970:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19970">
        <property type="entry name" value="RIBOSOMAL PROTEIN L39E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00832">
        <property type="entry name" value="Ribosomal_L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48662">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL19126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="51" mass="6260" checksum="8F9BBBD5B0C1130A" modified="2015-09-16" version="1">MPSNKTFRTKQKLAKAQRQNRPIPQWIRLRTGNTIRYNAKRRHWRKSTLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-11-27" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYJ9</accession>
    <name>A0A0G4NYJ9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Efficient mitochondria targeting-associated protein 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S002g001006</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM97/sigma-2 receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL19136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NYJ9"/>
    <dbReference type="STRING" id="1429867.A0A0G4NYJ9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051987">
        <property type="entry name" value="Sigma-2_receptor-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016964">
        <property type="entry name" value="Sigma2_recept"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204:SF1">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031032">
        <property type="entry name" value="TMP_97_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="9">
        <location>
            <begin position="8"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR031032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL19136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="162" mass="19059" checksum="5C0D9560BE20DCD0" modified="2015-09-16" version="1">MSICTRKRDLAYFLFFVTHVPIILLIDTVPLLPTFLQTTLSHNLREFYITTYRDKFFEDPPTWFTVFIWMELLYHLPLSIWAARGLLKDHPLVPVHLLVFGIQAFITTLTSLVVVWSWTDRSVAEKQQLTTLYAPYMALGGFMALDMVFRLRDKLMPKSKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYM8</accession>
    <name>A0A0G4NYM8_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S002g001057</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>UDP-alpha-D-glucose + 2 NAD(+) + H2O = UDP-alpha-D-glucuronate + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="3"/>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL19187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NYM8"/>
    <dbReference type="STRING" id="1429867.A0A0G4NYM8"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006024">
        <property type="term" value="P:glycosaminoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000001">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028356">
        <property type="entry name" value="UDPglc_DH_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374:SF3">
        <property type="entry name" value="UDP-GLUCOSE 6-DEHYDROGENASE"/>
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                <person name="Dupont J."/>
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        </source>
    </evidence>
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        </source>
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</entry>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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                <person name="Abraham A.L."/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0N0</accession>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL19887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="511" mass="55229" checksum="3F008BB48BE3AA86" modified="2015-09-16" version="1">MDLQKEITPSPPSPQDHEKGTIENFELDRLGYKQELRRNRSVLTLLFQTLAIAAIPYGEGSALLSAIYGGGPLSIFVGWIVVCVFDQCIAFSLAELASRYPTSAGPYYWTFQISRGNKTTLSFINAWIWLIGNWTITLSVNFGFASMLSATVSIYHPDWSASSWQLLLIFYAVCLTSLAICIFANKHLPLVDTLCASWTLLTIIIILIALSVKADTGRHSPSYTLSHYDKSFAGWGNFTFFIGLLPAAYTFSAIGMITSMAEECADPAVKVPRAISLSVPVGGTAGLFFIIPICATLPPLQDIINAPAGQALPYILARVMGSPAGGLGLISLVLVITVFCSISITVAASRATWAVARDDAVPLAKVWARVDERWGVPVWALVLLTGIQMLLGLINLGSSSAFTAFVSVGVIALAAAYAIPIFLSLWHGREEVAKAPWTCGGIFGRFVNVVALAWIAFELVLFSMPTALPVTAVSMNYASVVFVGFMAISGVWYVVYARKYYKGPPESDALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0Q5</accession>
    <name>A0A0G4P0Q5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">choline-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="9">2.7.7.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">CTP:phosphocholine cytidylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phosphorylcholine transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S003g000656</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.15" evidence="9"/>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P0Q5"/>
    <dbReference type="STRING" id="1429867.A0A0G4P0Q5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004105">
        <property type="term" value="F:choline-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000147">
        <property type="entry name" value="Cholinephosphate cytidylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045049">
        <property type="entry name" value="Pcy1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739:SF13">
        <property type="entry name" value="CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739">
        <property type="entry name" value="CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="13">
        <location>
            <begin position="161"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="355"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="429"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="450"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CRL19864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="470" mass="51723" checksum="AAD5E5A5D42FE7B2" modified="2015-09-16" version="1">MSPSTSPAGKRKRSASHLPAPVPKNVTADLQPSSRDASGEEGGDDSTGPNATSHSSNGTRHPSKRARKAAAADAASHTEVNGVEPAINKEDPGEPSETTVASSDIEGGPRSRPGLHIDLPEAEDDEPVTEEQMAPPVFGRLQDPVGYRTNPPPTGRSVRVYADGVFDLFHLGHMRQLEQAKKAFPDTYLIVGVTGDEETHLRKGLTVLSGAERAETIRHCKWVDEVIPCCPWIVTPEFLSEHEIDYVAHDDLPYEAAEGDDIYGPIKEQGKFLVTQRTEGVSTTGIITRVVRDYDQYISRQFKRGASRQELNVSWLKKNELEIKRHVVELRNNIRNNWTMTGQELGRELRQIWQNSRPNSPAPSARNSMDWGMRGPLTSPTGGSKSHLSRVGAEHNRADSPMGSRRNEDFATGYSLGLIGGVRAWMARSRQSLQEPPSGMHSPTDEELESEHNNGYEEEERGRAGHVSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P1R4</accession>
    <name>A0A0G4P1R4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S004g000195</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P1R4"/>
    <dbReference type="STRING" id="1429867.A0A0G4P1R4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF115">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL20255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="194" mass="21079" checksum="80B11F053035553E" modified="2015-09-16" version="1">MDHSMHMDMGHGDMGHGDMDMGGKCNMNMLFTWSSENLCIIFRSWHVTGPFSFLFSLIAIVILAAGYEAVRSATRKYEAAHAQRLSAFLGTTATTGDAEIADPIIANGLADAIPHTYHESSPLLAGRDNRAALVRKGKLITAALYAIQVFYSFFIMLLFMTYNGQVMIAVAVGAFVGYLAFSEGTPAEKTIACH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2L4</accession>
    <name>A0A0G4P2L4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S004g000490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0004040">
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF1">
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    </dbReference>
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        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="76"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL20549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="545" mass="59820" checksum="4A7B04BB4235E140" modified="2015-09-16" version="1"> </sequence>
</entry>
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    <accession>A0A0G4P360</accession>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL20770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="200" mass="22380" checksum="96C4547BAFC12770" modified="2015-09-16" version="1">MVQQRLMLVSLPPSSSELHDPMRLFTNMLANAAVIWFYNIMETLQVEIDEEIILVPLYSAYEIVGLAKPLTRFSFFKVRPPPFPPRELAVACVSHDVAQAHAFSPMLLYLSAKFLKTHADQVSTCVSASEDKQQKLEDLKKALRVLQGGNNLAMSYLELLDSDSDSLDKLCNLATAQGCTMSDVTGQPEPPFFLDIMHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3Q5</accession>
    <name>A0A0G4P3Q5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S005g000083</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195008" evidence="2">
        <location>
            <begin position="19"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL20919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="158" mass="15593" checksum="80021B3275372D65" modified="2015-09-16" version="1">MKPSIILTILGLSLTAIAAPTHLEARDVNADDANPTPPTPPTPPTPPVPPLIPAPATPPNTPGKGPGNYPVVPAAPPTPPTPPTPPSPPSPYSGPVNAPGYPYVNAPPTPPTPPTPPTPPSPSGPVYGPVFGSGNFPNAPATPPTPPTPPTPPTPSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3Q8</accession>
    <name>A0A0G4P3Q8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Calcium/calmodulin-dependent protein kinase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S005g000144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL20980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P3Q8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06293">
        <property type="entry name" value="Kdo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL20980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="223" mass="25387" checksum="48BA4247BE093A8E" modified="2015-09-16" version="1">MHPKSGPLREIDPSTIKIIGHITTSDASSIFEVEVDGQKYVLKLFHDNGDPGYAENGRDLNRFRCEFNAYEKLVTSGVSESRVVPKFHGYIDRVDPALFYPTFQHFAYDNFQPRGMLLEFLPNAESLNCVNFSDALFPQAIEGMKEIHKAGVHHRDIYPKNILLVRGNPDRLVWIDFDVATTFTDLDPEQLARSDHEIELVEGFGDALRDDQVEGLPPNTKFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P415</accession>
    <name>A0A0G4P415_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S005g000172</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P415"/>
    <dbReference type="STRING" id="1429867.A0A0G4P415"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF1">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
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    </dbReference>
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        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="91"/>
            <end position="544"/>
        </location>
    </feature>
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        <location>
            <position position="146"/>
        </location>
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        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="6">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="242"/>
            <end position="245"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL21008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="563" mass="61475" checksum="C7680738DEA6385D" modified="2015-09-16" version="1"> </sequence>
</entry>
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    <accession>A0A0G4P4I9</accession>
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    <protein>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S005g000357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P4I9"/>
    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL21193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="56" mass="6098" checksum="64FF074359786C70" modified="2015-09-16" version="1">MGSNALPYIETKPKLIFFTDFDGTITVDDITSLRLITLVSAGKSALHWATGSLTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P4T4</accession>
    <name>A0A0G4P4T4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S005g000482</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF224">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="72"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL21318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="462" mass="49555" checksum="D9F5E9551C0F03F7" modified="2015-09-16" version="1">MANNETEAAPSIDSATTIPVVNLHGGNDPEKGLAPSEKDEAQPSTEKSIAASPAPATPAIGPPPDGGAQAWLVVLGAFCGLFVSFGWINCIGVFQDYYQSHQLSEFSTSTVTWITSLETFMMFFCGPIFGTMFDSYGPRWVLLLGTILHVFGLMMASLSTDYYQFILAQGICSPIGASAIFNASVNSVSTWFAKRRGFALGVTASGSSLGGVIFPIMVTQLIPKVGFPWAMRICAFLILFMLGIANLTLKSRLPHRPKPFDILNFVRPLTELKFALTLAGAFCFFWGMFLPFTFVITQAERYGMSANLAGYLVPILNAASIFGRTLPGYLADKVGRYNMMVMTTFFSSILVLALWLPSRGNVPAILFSALYGFGSGAFVSLAPALVAQISDLRQVGVRNGTFFAVISFAALTGTPIGGALVPDVLHGDYTRLQIFCGVVMIVGSVLFVFARGAVGGFKLNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5B5</accession>
    <name>A0A0G4P5B5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PCAMFM013_S006g000038</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P5B5"/>
    <dbReference type="STRING" id="1429867.A0A0G4P5B5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000016">
        <property type="entry name" value="Solute carrier family 25 member 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
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</entry>
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                <person name="Dupont J."/>
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            <dbReference type="PubMed" id="24407037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
    <sequence length="79" mass="8677" checksum="E85F54AB46FE59E5" modified="2015-09-16" version="1">MSTYLHIPPSLSILPSLSAYRQLPNQVDGATSRLKIPSHLHCSLGDSCFSHFHKSPLTTDRPLSVPSARETPKSMFSIS</sequence>
</entry>
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    <accession>A0A0G4P5N2</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="221" mass="22048" checksum="32B201DCB6EAC6A2" modified="2015-09-16" version="1">MHLVNVAAFACAVISASAFEFPDFVPLHRRQDPGTPAYECHANCGGVITAGRTDGYCDTDDFKTELTDCLNCAVEFDIWKYYGGSVSKAATACGLDATPVEASSTSTEASSTSAEASATSAEETSTTTSVSATTTEESVNSAVTTDAVTSTGTTVAATSVSPPRVSGSSRPSSLIPSATPAGSSTASTPSSSPVYTGGATINAGSGLVSGAFAGCLIAAFM</sequence>
</entry>
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    <name>A0A0G4P5S0_PENC3</name>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
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                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>P(1),P(3)-bis(5'-adenosyl) triphosphate + H2O = AMP + ADP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13893"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.1.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
    <dbReference type="GO" id="GO:0047710">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051884">
        <property type="entry name" value="Bis(5'-adenosyl)-TPase_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039383">
        <property type="entry name" value="FHIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46243">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46243:SF1">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="8">
        <location>
            <begin position="9"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="142"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="5">
        <location>
            <begin position="101"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="2">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="96"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for induction of apoptosis" evidence="4">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL21656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="200" mass="21682" checksum="F5514E9D28A679F0" modified="2015-09-16" version="1">MSALKGATTPIYFGSFIVTPQVFHTTPLTFALVNLKPILPGHVLVSPRRVVPRVTDLTPAETSDLFLTVRRVGRMVERVYGATSLNIAIQDGVHAGQSVPHVHAHIIPRKAADLDHAGGTDAVYDLLDGDEGDLGRVFKNAVPTEEGNQSPEVGNGNAVNSGRRSRFPVVDNDARKPRGEEDMRAEAEMLAQEMENEPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6L0</accession>
    <name>A0A0G4P6L0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Aromatic-ring hydroxylase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S006g000500</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P6L0"/>
    <dbReference type="STRING" id="1429867.A0A0G4P6L0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050562">
        <property type="entry name" value="FAD_mOase_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356:SF2">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE ASQG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="531"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="561"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="607"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="641"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="681"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="768"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="10">
        <location>
            <begin position="8"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="10">
        <location>
            <begin position="298"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL21960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="806" mass="90209" checksum="01A03FDDCD1AC64A" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7H6</accession>
    <name>A0A0G4P7H6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Protein PNS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S007g000223</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Probably involved in transport through the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cell membrane</location>
            <topology evidence="2 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P7H6"/>
    <dbReference type="STRING" id="1429867.A0A0G4P7H6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF4">
        <property type="entry name" value="PROTEIN PNS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="444"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL22242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="546" mass="60471" checksum="3C67667E9EB40E02" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7V8</accession>
    <name>A0A0G4P7V8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S007g000371</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P7V8"/>
    <dbReference type="STRING" id="1429867.A0A0G4P7V8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF7">
        <property type="entry name" value="NADB-LER2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL22390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="250" mass="26512" checksum="6BC7CE1C3EEE1D75" modified="2015-09-16" version="1">MTISENTVVLVTGARIGRTLVETFLLRPKHTVISSVRNIDADYVKELEALPKADGSRLQLVKIESSNSGDPAAAVKNLTDIDHIDIVVANAGGAGEKGIIPLDIVSPEIVTDVFTVNALGPLALYQAVKPLLEKSQAPKWVSVTSAAGSIGRLEIYRAHIAPAYGIAKAGLNWITTAIHSANKDFIAFAVHPGLVQTESGNKSARAMGLPQAPNSQRQSVDAILGLIDTATRETTSGKFFNVIDGTEIPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P8M4</accession>
    <name>A0A0G4P8M4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC-2 type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S008g000053</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P8M4"/>
    <dbReference type="STRING" id="1429867.A0A0G4P8M4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="ABC-2 type transporter transmembrane" evidence="7">
        <location>
            <begin position="203"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL22624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="350" mass="40034" checksum="2D7544575E553C34" modified="2015-09-16" version="1">MEMIRNVAIAGAPGALGSPIIHALLQSEFFNVTVLAHLSSQAQFPASVKVIRVDYTSVPDLTMLQADLLDVTSVVTLYQAPQSSYDLFDRVTLIYEGRQIFFGPTTDAKKYFESLGFCSLPRQTVPDFLTSMTSPEERRVRAGFEYSVPRSVDEFAERWRSSEPRKKLLFELASYEQRHPRKERTKEYYHSRRAEQAKEQRSNMFYDLKPDTSSFYYRGGLIFFSLLFNAFASQLEVLTIYAERPIVEKQNRYAFYHQSAQAIASYLTDLPYKIVNMFVFNILIYFMANLRREAGAFFFFCLTTLLTTLVQSAIFRILACITRTSGQAIIPSAVLGLGLMIYTGFTTPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P8T0</accession>
    <name>A0A0G4P8T0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VanZ-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S008g000157</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P8T0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037970">
        <property type="entry name" value="vanZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28008">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28008:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL22728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="218" mass="24227" checksum="2E9DED6FE2E3CDF1" modified="2015-09-16" version="1">MRIRYPFAGAFIFLLFLAGYIGLLPHSTSSTIPTQLQPNDKFLHLVTFFLLSVTFYWVLDTTRRRTLHVTLVVCTLGLGIGSEVVQGFLPNGRDFDIFDIVANVVGSVGAVGLCNWYHRRMMERRRQSRYGMMEEGTEDVELGGVGNSRRDSEIMGPQESGVMSLEQEVDNWDENAVETWDTEEGPSPERETAPPSYHEAGPVGGQSAAIPAAAKRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P8W7</accession>
    <name>A0A0G4P8W7_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S008g000148</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays an important role in cellulose degradation. Shows hydrolytic activity against several glycosidic compounds.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P8W7"/>
    <dbReference type="STRING" id="1429867.A0A0G4P8W7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080079">
        <property type="term" value="F:cellobiose glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000011">
        <property type="entry name" value="Cytosolic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF134">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL22719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="488" mass="55836" checksum="A7C9A9857269F6D0" modified="2015-09-16" version="1">MDLNSVQDLKNVLRPDFFHGYATAAAQIEGAWNKDGKGVSIWDTFGHTPGKIADGSTADDAVRAYDFYREDVALMKSYGVNAYRFSLSWSRIIPLGGRDDPVNEQGIKFYSDLIDELLRNGITPFLTLFHWDIPQALEDRYGGMLNQDAYTPDFVRYARVCFERFGDRVKHWITYNEPGVYTLAGYAAGVHAPGRSSFRERNAEGDSSTEPFTVAHTELVSHGHAVRLYREEFQPQQKGTIGITLHGNWSEPWDEEDPRDQEAAERAREFEIAWFADPLYKTGDYPASMRAQLGDRLPRFTEEESKLVFGSSDFYGMNSYTTFFVKHTTSAPDINDHKGNVEIFDENKQGVSRGEESDTPWLRAAPGGFRKLLNWIYKRYQMPIYVTENGTTAKGETAPTPEVLNDEFRIRFFEGYVGNALARAVKEDGVDIRSYFAWTFTDNWEWAAGYADRFGSTFIDFESEEKTRYPKQSAYYLDKLFKHLIKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P954</accession>
    <name>A0A0G4P954_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S008g000270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P954"/>
    <dbReference type="STRING" id="1429867.A0A0G4P954"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195142" evidence="1">
        <location>
            <begin position="25"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="84"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL22841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="347" mass="38162" checksum="BCB2ED7EE0672549" modified="2015-09-16" version="1">MKIFSVFSTLSAVLSFAAVVPAQSDPDPIGTIYDGHVPADLYGSSYPYPWPVKLFNFSNQRQNLTMAFMDLPPKKQNKNKKTAILLHGGNFCGVTWSDTARHLSASGYRVILPDDIGFCKSSKPQGYSYNVQQQALNIHSLLTALGIDQVTVIGHSMGGMIAARYGLMYPASVHQLVLVDPLGLEDWVAKGVPYLSIDATYESQIVQNFTTLKAYEEASYFHGASWKPEYDTWVHMLADIYAGDYGSQYSYVMSLVTDALLSQPIIYQLPLLQTRTYLMVGENDVTALGKAWSSPAVAAKLGHYSELGPAAAAMIPNSTFHMFPGLGHAPFLQDPKAFYGVLFSWLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P9E1</accession>
    <name>A0A0G4P9E1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase superfamily, zinc-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S008g000344</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P9E1"/>
    <dbReference type="STRING" id="1429867.A0A0G4P9E1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="15"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL22915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="352" mass="36553" checksum="E8E48D67B3172E6E" modified="2015-09-16" version="1">MAQTPENKAAWLPASQVTPLQISPAPYTSPGPHQIVVKNSALGINSVDWAKQMLGEALLGHISYPFILGEDVAGTVVEVGEGVQRFGVGDRVVAAASAISVNSSLEGGFQLYTVIREWLAAPLPDNITFEQGSVLPLAIFTASHGLFDTGYLGLDLPTVPARQSSDKRAIIITGGSSAVGSTAIQLAVSAGYEVMSTASPKNFDYVKKLGATHVFDYKSDTVIDDISAAVKGLHLAGGYSIGDGSIDLLAAVLERHEGPSVNKVIALAGGKPGGGIIDPSIQVKFILLGPDAAGPDSVVSKVYTSYLPDALANRQFVPAPEAIVVGQGLEKIQEAFGIHMQGVSAKKIVVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PA91</accession>
    <name>A0A0G4PA91_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetoacetyl-CoA synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S009g000176</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PA91"/>
    <dbReference type="STRING" id="1429867.A0A0G4PA91"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005914">
        <property type="entry name" value="Acac_CoA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01217">
        <property type="entry name" value="ac_ac_CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921:SF4">
        <property type="entry name" value="ACETOACETYL-COA SYNTHASE (AFU_ORTHOLOGUE AFUA_8G04770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="112"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL23236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="679" mass="75660" checksum="86A8AC608348BD32" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBD6</accession>
    <name>A0A0G4PBD6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WW-domain-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S010g000064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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            <end position="224"/>
        </location>
    </feature>
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        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL23626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="224" mass="24483" checksum="B2BFAAFBA1353B29" modified="2015-09-16" version="1">MLDDQDGFVRLPNERLIYSSPPRTSVSLTPPSGYKGAEKLSIQSSAGCIHLTNQRVVYLPASRSNDFQSFSSPLLNVRDSHVSAPFFGPNVWTALVQPVSGGGISPSLPAVQLKVTFKEGGAFDFHTNFERIKERLEQAVENTSEGTRGQQNVDLSAVHLEELPAYEAPPNASQSVRPSQTPEESQSSRASDTGTEPVEPPPCYEEVQSQSVAQELEERLRRAT</sequence>
</entry>
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        <submittedName>
            <fullName evidence="7">Winged helix-turn-helix transcription repressor DNA-binding</fullName>
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    </protein>
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        <name evidence="7" type="ORF">PCAMFM013_S010g000319</name>
    </gene>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
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                <person name="Goarin A."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="entry name" value="HSF_DNA-bd"/>
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    </dbReference>
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        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2 7" id="KW-0238">DNA-binding</keyword>
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        </location>
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        </location>
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        <location>
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            <end position="559"/>
        </location>
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            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
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        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
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            <end position="354"/>
        </location>
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            <begin position="390"/>
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            <begin position="437"/>
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        <location>
            <begin position="517"/>
            <end position="531"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL23881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="559" mass="61335" checksum="E6945FE65DEFB32E" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCC5</accession>
    <name>A0A0G4PCC5_PENC3</name>
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        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S010g000357</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
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    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF38">
        <property type="entry name" value="CHITIN SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="707"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="746"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="777"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="821"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="856"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="954"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="981"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="12">
        <location>
            <begin position="286"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL23919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1083" mass="120479" checksum="9D45DB323B9AC6B7" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCD1</accession>
    <name>A0A0G4PCD1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S010g000423</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PCD1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PCD1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL23985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="316" mass="33091" checksum="3DC7468BAA3E6578" modified="2015-09-16" version="1">MAQYYPQQQGYAPQGSAPQNLQFFPSSYSSVSGHTTPSQASYGAGFGGAPNPSAQAYPTGSGYGGFGSPAAGVSGRMGEQGGLRTGWLAAFGTEGYDGEPPLLEELGVNFEHIRTKTLTVLNPFASIDNHLMDDSDLYGALLYIVLYGTFLLLSGKVFYGYIYGVAVFGTVALHLILSLMSPALDTVPTPNAADPTNYNPHHKPSMSGASAAGHFSATLTFPRSASVLGYCFLPLVLTSLIGIMIPMDTMFGYLLTIAAVGWCTYSSSGMFCAVARMSGMRGLVAYPLALFYVVFGIMGIFSSRGIGSLAAKTGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCJ9</accession>
    <name>A0A0G4PCJ9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S011g000027</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP4R2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PCJ9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PCJ9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015267">
        <property type="entry name" value="PPP4R2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16487">
        <property type="entry name" value="PPP4R2-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16487:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09184">
        <property type="entry name" value="PPP4R2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="333"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL24033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="392" mass="41006" checksum="1B2EEF4FF8A08AB6" modified="2015-09-16" version="1">MSLDEEALQTAANGGAIDLERWSGIAGPLIERLEYIVYNVFPMPQARPEPIGQQSFPNHSSQANSIPESSNKENTSPTDIQTSPQAARTGSPPSSERVPDSQPQPSSASTDGRLPPPLAFLLSAIRSSIKSFFEDKPPHTIQRLAELVLYPTKHYRTLPAYLRAVDRVVSVTSSADIFPFQTPAVTDAQSNGLVLPGNSSGVYMAPDFAQGLGSDESLGGALLTPIPWLTNASFEGEDANGDSGILVEGTEALPTQPEEQGTTTLVPAEAEETAATTSPEPSDEVPHARGPIVLGVEDMGLQDGKGVEMHLAADGAADVPAAAGTTTTQATEEQEKAEPTGDKDGDIVLADTNPKEGEEAQNEGPSTESQAGNAESEPTGNSSQAPDAEKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PD81</accession>
    <name>A0A0G4PD81_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S011g000282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PD81"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL24288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="117" mass="13465" checksum="A97306841E1E5344" modified="2015-09-16" version="1">MLDLRQPGKIEPKQVRCPGERPTCTRCISTNTSFCYSSRKQLGRPKARKDHHKSSRRRHCNPFAGARPRSRSFNTCACLSEQYLLLEQLRLKTQLVVPDDLHMLRGTIQKAIDVLNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PE22</accession>
    <name>A0A0G4PE22_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S012g000162</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PE22"/>
    <dbReference type="STRING" id="1429867.A0A0G4PE22"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022703">
        <property type="entry name" value="DUF3533"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053001">
        <property type="entry name" value="MNNG_permease-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814:SF2">
        <property type="entry name" value="DUF3533 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12051">
        <property type="entry name" value="DUF3533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3533" evidence="3">
        <location>
            <begin position="32"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL24552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="509" mass="56481" checksum="6866131E1210BD8F" modified="2015-09-16" version="1">MFYPKARQRRPSIHHPTVRPLRLGLLKAATVNLLLLQFLFLGLFCYIFGALFQQSGHIHNINILFVDYDGGAIGDAARVAYQKLKGPSFPTFVERSASVYPQPGSIEGAVCDIEYWGALYTTANASNALSAAFAGGSAASLYDKTNVLTMVWNEVRYPTVVDSAVAQSIKLLSETARVAYSQANAKDALQSVNSSDPAALAAFYDPWTLADHNILVTSQGSRAIYNTLVIILILIQEFFYLGTVNGLYAQFKLYTSVSPHRIVIARQIISLIYTLAGSMCTAGAIWAFRSGWDVNGNQFALTWLALWLFAHLNFLVLDVFTIWIPPPYIPMALISWVILNVTSIILPFELSPAFFKVGFALPAHAVFQVLIDIWSSGCNPQLYFSLPVLFVYEVLGITLSSIGVYRRAHYACIKQEMDEKASEERVTAILREQQEAQLVRRETMHDVEGSETSDSEDEPRGMQRRGTGTTADQADLVNIMSREMSRSKVDRPDTGRDSTGPSFALAYKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PEC7</accession>
    <name>A0A0G4PEC7_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">sarcosine oxidasee (formaldehyde-forming)</fullName>
            <ecNumber evidence="3">1.5.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S012g000224</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>sarcosine + O2 + H2O = formaldehyde + glycine + H2O2</text>
            <dbReference type="Rhea" id="RHEA:13313"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57433"/>
            <dbReference type="EC" id="1.5.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EC" id="1.5.3.1" evidence="3"/>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PEC7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PEC7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000189">
        <property type="entry name" value="Monomeric sarcosine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008425">
        <property type="entry name" value="PRK11259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF7">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="8">
        <location>
            <begin position="5"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL24614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="380" mass="42030" checksum="E0D208C19E5CD922" modified="2015-09-16" version="1">MEHYDIAVVGLGALGSGAAYHSALKGAKVIAFEQFEFGHVRGASHDTSRIVRTSYDAPEYAKFAKSSYKDWGELEKRTGQQWLTITGGVIVFPKGSQKLARDYTHSLDVNEHTYELLTSEQVKARWPQFCVPVGSHTVYTADMGIVHASKSVAAMQYMARSLGALLKEHTRVDRILPQANGAIIETSRGRLSAGKVIIAADAWANKLLAPLGADIPLDVMQEQVTYFKPENPEAYEPDRFPVWAYAAEDGNFYYGFPAYGEPTLKAGRDIAYNRMSPEERTFVHSEELLQELTRHMEGFIPGKGQVLRTVTCQYAITPNRQFVISPLEKHRDILIGLGGGHAFKFAPTFGRVLAELAIDGKTSDDISKFGIPKSVPMSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PEK4</accession>
    <name>A0A0G4PEK4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S012g000365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PEK4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL24755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="330" mass="38605" checksum="D2A099C25BAED2EE" modified="2015-09-16" version="1">MSSSTQLDTNPDETMCLAVERFRTKMESSNRQFIQDRIDEIEAMNLSTEDEKLHHMLSYWPDLDIKDLSVWNDCAPRDTIRQAREVANVSRLEDLQTTFHQYMDGIIPSTLVTDEWREMFLETVESVCNEAAEQDEDDEDFHIPRCDELGHFIKYANGVKDPDFRHSGICQWEPVSGLIGIRDFAFPDHPSVQALPPPDIAESRERLKGYLQDNILGEAFIYGTVDKDLEVKVGFQTGLGSRREHDEWYSAYIYCRRCEDDSDPSHEDWAWQVVIMHACGGNPTLLYGRKPRFDSIPEFLDWYSSWLDHYDIEEDRKQVKLMYGSDEEWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PF72</accession>
    <name>A0A0G4PF72_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AMP-dependent synthetase/ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S013g000185</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL24942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4PF72"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000014">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
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        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="575"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1679"/>
            <end position="1764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL24942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="2188" mass="242448" checksum="A550F34008872A34" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PFJ6</accession>
    <name>A0A0G4PFJ6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein HGH1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S013g000325</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    <comment type="similarity">
        <text evidence="2">Belongs to the HGH1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL25082.1"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
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        <property type="entry name" value="Protein_HGH1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007205">
        <property type="entry name" value="Protein_HGH1_N"/>
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    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04063">
        <property type="entry name" value="DUF383"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="649"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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    <feature type="transmembrane region" description="Helical" evidence="12">
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    <feature type="transmembrane region" description="Helical" evidence="12">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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        </location>
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        <location>
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        </location>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
    </feature>
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            <end position="588"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04063"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04064"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL25082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1376" mass="154159" checksum="F5C0BECFE421D34C" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PG16</accession>
    <name>A0A0G4PG16_PENC3</name>
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        <recommendedName>
            <fullName evidence="3">DUF829-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S014g000159</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793147">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PG16"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <source>
            <dbReference type="EMBL" id="CRL25263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="32648" checksum="966D11908D2308EA" modified="2015-09-16" version="1">MAPQPIPFPGFTPISDRVYLRDGHEKAKPCPADEPTTIIISGWGDGMPKHVTKYSDGYHELYPSARIIVILSRTFQATHQPEEARIAAMMPVVDTVFPTPTGSGSEKERLLVHAMSNTGAIFTASVVVAYQRRHGTDKPFPHQLLVLDSTPGSLVFTSQVTRWSRAMAVGTAKFFPWPFVITQGIWYVFLWGSYLWQLLSRSEASGVWADRIINDKSCVTTDSSRVYLYSKEDEIIGYQDLEENVAHAKTLGYSVDLEMFEGSPHVGHMRLHPEQYWGKVASSWKQAIAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGI4</accession>
    <name>A0A0G4PGI4_PENC3</name>
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        <recommendedName>
            <fullName evidence="13">Ras-related protein RSR1</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S015g000045</name>
    </gene>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="3"/>
    <dbReference type="EMBL" id="HG793148">
        <property type="protein sequence ID" value="CRL25459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PGI4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PGI4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000114">
        <property type="term" value="P:regulation of establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04177">
        <property type="entry name" value="RSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000631">
        <property type="entry name" value="Ras small monomeric GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041841">
        <property type="entry name" value="Rsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0636">Prenylation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="172"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CRL25459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="211" mass="24275" checksum="5CBA238EF1483DFF" modified="2015-09-16" version="1">MRPQREYHIVVLGAGGVGKSCLTAQFVQNVWIESYDPTIEDSYRKQIEVDGRQCILEILDTAGTEQFTAMRELYMKQGQGFLLVFSITSMSSLNELSELREQIIRIKDDENVPIVIVGNKSDLEEDCAVPRARAFGLSQKWGNAPYYETSARRRANVNEVFVDLCRQIIRKDSEGSRSSNDPNRKREGPNRHDRKRDNRRPRNRRGPCIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PH70</accession>
    <name>A0A0G4PH70_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide-like helical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S016g000006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793149">
        <property type="protein sequence ID" value="CRL25725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PH70"/>
    <dbReference type="STRING" id="1429867.A0A0G4PH70"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45588">
        <property type="entry name" value="TPR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45588:SF1">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="22"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL25725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="565" mass="63437" checksum="F65141EC2196A0F8" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PHI8</accession>
    <name>A0A0G4PHI8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin repeat-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S016g000014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793149">
        <property type="protein sequence ID" value="CRL25733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PHI8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PHI8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL25733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="286" mass="31909" checksum="456DFE69513A0BC9" modified="2015-09-16" version="1">MLVRNPRVDVNCFNRRQETPLLLAVKGHGRFLPIKKRLLVIEALLLSPCINLNYQDENGRTAIWYAVSNSDVKLVELLLQQTNLDLNCADKLGQTPLAKAAAKGSLDLIKVLFRQPGLHKSPQFTDAFPPLWSACRAGKFAAVEFLLQNSADINQISPSGTSPLEVAIIMEHVDIVHLLVSYEKSLLINDQNHCSSFTALMFASALGRVEIAKILLEYPNINVNAVDDQGRTSFWWAAAGGHYKVVQLLANRRGVKKRLKDTNGRTAYAIAKERNHGHVTVYLRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PHN5</accession>
    <name>A0A0G4PHN5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sugar/inositol transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S016g000136</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793149">
        <property type="protein sequence ID" value="CRL25855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PHN5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015793">
        <property type="term" value="P:glycerol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF55">
        <property type="entry name" value="SUGAR TRANSPORTER STL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="17"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL25855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="539" mass="59594" checksum="903F2905130DC226" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PI27</accession>
    <name>A0A0G4PI27_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S017g000025</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793150">
        <property type="protein sequence ID" value="CRL26042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PI27"/>
    <dbReference type="STRING" id="1429867.A0A0G4PI27"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF1">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL26042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="285" mass="31744" checksum="E899449855BDC4B1" modified="2015-09-16" version="1">MENHITERSYGYVDPNFPNPGGERDTPVIIYGYTPSIALAAFAAAWFFLHFVYHTAQTIKTRSWWWMTFSAGLIFEVIGYIARSLSAKKDPYHLIYFILNYFFIVVAPVLLAAGIYTILSALIPRVGTRYSFLPPKIILAFFITSDVISTIVQVAGACLIGITESRREDPTTANNILLGGLAYQVFVMTIFVIVAASFQFRARHAIRANGLGLFCLAFSISTLMVYLRTIFRLAETGQGLMGELQTNEVYFACLEFAPIALVALLFAVWYPGRCVGAAVRVNDKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PID0</accession>
    <name>A0A0G4PID0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable kinetochore protein NUF2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Probable kinetochore protein nuf2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PCAMFM013_S016g000239</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NUF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793149">
        <property type="protein sequence ID" value="CRL25958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PID0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PID0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051383">
        <property type="term" value="P:kinetochore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045132">
        <property type="term" value="P:meiotic chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.60:FF:000003">
        <property type="entry name" value="Probable kinetochore protein nuf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.60">
        <property type="entry name" value="Ncd80 complex, Nuf2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005549">
        <property type="entry name" value="Kinetochore_Nuf2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041112">
        <property type="entry name" value="Nuf2_DHR10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038275">
        <property type="entry name" value="Nuf2_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650">
        <property type="entry name" value="MEMBRALIN/KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03800">
        <property type="entry name" value="Nuf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18595">
        <property type="entry name" value="Nuf2_DHR10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="13" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Nuf2 N-terminal" evidence="17">
        <location>
            <begin position="34"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Nuf2 DHR10-like" evidence="18">
        <location>
            <begin position="287"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="167"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="359"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF18595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CRL25958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="469" mass="54795" checksum="ED1BFD373736B105" modified="2015-09-16" version="1">MSRNSTAMGYNSRMSQQFQGNQHHGRGRKKEDENDALMRLPDKEIAGCINDIGIPFTLADLAKPNAQQIQMVFEWFAELLMNTTRETVEPAMHAAAEDLCGDYPDIVPNDTRNLMGFFMMLRKLLAECGVNDFTFTDLTKPTHERLVKIFSYLINFVRFRESQTPVIDEHFNKTEKTKSRIDELLAENQEMELRLREMRQDLQSNEAHVREKVSRNDALKARLLELGREQSRVAETLDRVKTERARRQQQLEEKTERTVRSRQEAEKLRPYVLESPATLQSSLAELSENLMREKASIDAMERRARALQTSSDTFTVVSNDVQGCVKLLDDISAEMQKEDEEESRAARTAEAISDRGNSVREVEQTEKLLQRQLARWLERIEALQKNAQEKAELAQARMEELRNVQKQLREERAEKQRDMERRRIRIEQTEKKMVDLKENIETEIQSAHDQYLKLESHIKLYMTEMEKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PIS4</accession>
    <name>A0A0G4PIS4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Required for respiratory growth protein 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S017g000227</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for respiratory activity and maintenance and expression of the mitochondrial genome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRG9 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793150">
        <property type="protein sequence ID" value="CRL26244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PIS4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PIS4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010487">
        <property type="entry name" value="NGRN/Rrg9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475:SF3">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06413">
        <property type="entry name" value="Neugrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="59"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="114"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL26244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="291" mass="33659" checksum="37B54B7DC2C64D69" modified="2015-09-16" version="1">MATKCAASSRLALPAVLRNVFRSQFTSNLGASSIIPYHRPLASGPLFPSNIQLQRSFNSMPRLGDSQNDEPAPAAPETPAAADDTVPSQHKTPKRKDYDSFGKKGGWNNHKSHPKDQRRDPDSTGRTDRERRAFRNETRREAKKEPRKDWQDRAQKSKQFSENRGKRKPESWQVQKAALKEKFAGGWNPPKKLSPDALDGIRHLHAKAPEQFTTAVLAEEFEMSPEAIRRILKSKWRPSEDEMESRRKRWENRHDRIWSRMAELGLRPSTDRTRTLSDFHVLYDDNNRERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PIX5</accession>
    <name>A0A0G4PIX5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S018g000020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PIX5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PIX5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF286">
        <property type="entry name" value="5-PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL26327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="442" mass="49226" checksum="E3AF5B709CAFD719" modified="2015-09-16" version="1">MDALGVYVLTFNCARNFVDVDAFANHFFDALPASGAGSSAPDLIFLSLQEIAPIAYSFLGGSYLLPYFDAFRRAVQKASAQKWGQHYVNFLNDNTGMTGLMLFARDDTLGKIAWRDTAHVGLGVQEMGNKGAVGARLGYVVEGYPSKTVDLTFVAAHLAPMEDSYEQRNMDWKSIVERLVFTHDSNKPAERSSMDENTSLLEDAASAHAEGSRRDLFAPNAYLFLAGDLNYRTSNVGPSIREIEQFPRRNVDLDNPSHYSHLLKNDQLVREMSYGRTFHSLSEAPIDFPPTYKYSDAAREAVRLGLNTDDHEWKWSNHRWPSWCDRVLFLDKPWAGEAGKVKPLAYNALPLFAQSDHRPVALVASVPLRPSDASPNTENIRAVAPFSIDPSWKSKRDMARRKELVVGAVAYLGLTREGNGLLLASLLGIIGAWFILRSMLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJ87</accession>
    <name>A0A0G4PJ87_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S018g000163</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJ87"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033229">
        <property type="term" value="F:cysteine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF63">
        <property type="entry name" value="HIGH AFFINITY CYSTEINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL26470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="530" mass="59426" checksum="2A69B872E1F1DAC2" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJB7</accession>
    <name>A0A0G4PJB7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S017g000261</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793150">
        <property type="protein sequence ID" value="CRL26278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJB7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJB7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000528">
        <property type="entry name" value="Nucleoside-diphosphate-sugar epimerase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="4"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL26278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="211" mass="23007" checksum="152DDD80BBD5B328" modified="2015-09-16" version="1">MVAVLITGATGKQGGALIKSLIARKCSFEVLAVTRNAQSPSAQKLAKLSSNIKLVEGNMDDPAAIFQNARQVAKSPIWGVYSVQVAIGNGALEESQGKALIDESLKENVQFFVYSSVDRGGDASYTTPTKVPHFINKHNIEHHLVERSKNTDMRWTILRPAAFYENLVPGFFGKVFATSFKMALKGKPLQMVATDDIGFFGAEAFLHPEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJG9</accession>
    <name>A0A0G4PJG9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S018g000187</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJG9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF59">
        <property type="entry name" value="UNC93-LIKE PROTEIN C922.05C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="413"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL26494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="474" mass="52950" checksum="5B1272AD8813DBBF" modified="2015-09-16" version="1">MAEQGSISASSDTPIEKRVWYRGTLFNACIIGGVGFTAPGLWNAMNALGAGGAQEPFLINAANALVFGLMGILCLFGGPIANRIGLRWTLMLGAVGYPLYSAALYTNNRFGNVWFVLVGSVFCGLSAGLFWASEGAVALGYPEPAKRGRYMNIWLWFRTGGPLVGGAIVLGLNHAADAHARGKVGSETYLIFIALQCTAVPIAFFLTSPDKVQRTDGSKVRIILQDSWRDEMKELWKVCQRKEILLLLPVFWAAYFNMYTGNFKTYYFGVRARALMGFVTYFATLLASTLISRFLDYRGLSIRNRIKYSFFYVIVVHIVAWVYCWVIQEKYTKNPPTLDWSDKGFVEGFFVVLLWEFAQQSLQNFLYYLLSTMTDNISELSRLSGILRGQESFSQAVSYGLNSKKWHGGRVPLIVNTILLVLSIWPTWLVVRSHVPIEHSKEVAELPQAQDEEQNKVSLSDKETFVVAEAVASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PL02</accession>
    <name>A0A0G4PL02_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Ferric reductase-like transmembrane component, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S019g000248</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PL02"/>
    <dbReference type="STRING" id="1429867.A0A0G4PL02"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
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        </location>
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    <sequence length="770" mass="87348" checksum="7944674E24CEC61A" modified="2015-09-16" version="1"> </sequence>
</entry>
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    <accession>A0A0G4PL48</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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    </evidence>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <source>
            <dbReference type="EMBL" id="CRL27379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="74" mass="8782" checksum="F0330D14D8832D3C" modified="2015-09-16" version="1">MDKPEKNDNNCDLDLNQIWRNSSRLSTPALTLTVNHNDRLYYPKVTEYAIYEVQRPLLVKCFFYPDHESQSGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PM30</accession>
    <name>A0A0G4PM30_PENC3</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
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        <lineage>
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        </lineage>
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    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Dupont J."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
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        </subcellularLocation>
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        <property type="entry name" value="MCP"/>
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    <dbReference type="InterPro" id="IPR050567">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF12">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="16"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="113"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="214"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL27241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="304" mass="32971" checksum="941ECCEDF93D03DA" modified="2015-09-16" version="1">METEVIDSLDKGGGALRTIKDLAAGAAGGMAQVLLGQPFDIVKVRLQTTTQYKSALECATQIFKNEGPTAFYKGTLTPLIGIGACVSVQFGAYHEARRRLEELNKKKYADSTLSYTQYYLAGSFAGITNSVLSGPIEHVRIRLQAQPHGAGRLYSGPIDCVSKLAAQGGALRGLYRGQAVTLIREAQAYGAWFMAFEFMMNQDAKRNNVKREDLSKAKIAIYGGLAGEVLWLSSYPFDVIKSKMQTDGFGAQQKFSTMRDCFKKTYAIEGLGGFWKGIGPTLLRAMPVSAGTFLTVELAMQALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMD7</accession>
    <name>A0A0G4PMD7_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S023g000055</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793156">
        <property type="protein sequence ID" value="CRL27597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PMD7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PMD7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22881">
        <property type="entry name" value="Mdv1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000404">
        <property type="entry name" value="Mitochondrial division protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000881">
        <property type="entry name" value="Mitochondrial division protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF28">
        <property type="entry name" value="CCR4-ASSOCIATED FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="315"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="357"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="432"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="515"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="538"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="237"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="396"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="396"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL27597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="656" mass="72311" checksum="EC0165309020D702" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMK2</accession>
    <name>A0A0G4PMK2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S023g000042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793156">
        <property type="protein sequence ID" value="CRL27584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PMK2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL27584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="79" mass="9042" checksum="25D48133DA906A30" modified="2015-09-16" version="1">MLRPTDNEAVYYLYKFPFYSKPSLNPQNGAEMNMQQQCDGHAQRSSTVDGSRLLRIPHPGVQWLEAGHHSGQESQWNIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PML9</accession>
    <name>A0A0G4PML9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S023g000148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793156">
        <property type="protein sequence ID" value="CRL27690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PML9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PML9"/>
    <dbReference type="ESTHER" id="pend2-k9gep5">
        <property type="family name" value="ABHD13-BEM46"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="2">
        <location>
            <begin position="103"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL27690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="311" mass="34341" checksum="35DE0B733F124212" modified="2015-09-16" version="1">MSDSPPPPSWSISSMANSAAQFMRLPVLASSGLAVVASGLLYFKQNELIYPRNVPVDARTNVPSPRQFGISDFEDLQIPTPDGESLNALFLRQRPGRFSRNLTVLMFHGNAGNIGHRVPIAKAVQDTLQCNVFLLEYRGYGMSTGTPDEAGLKIDAQTGLDYLRQRPETRDTEIVVYGQSLGGAVAINLVATNEEQGDIAGLILENTFLSIRKLIPNVFPPARYLARFCHQYWTSEDVLPNITKTPVLFLSGLKDELVPPSNMTQLFAVCQSECKIWRTLPNGGHNDSVAEPGYFEHILSFITEEVLSNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMW4</accession>
    <name>A0A0G4PMW4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nuclear transport factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S024g000037</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793157">
        <property type="protein sequence ID" value="CRL27782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PMW4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PMW4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17325">
        <property type="entry name" value="MFS_MdtG_SLC18_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="347"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="627"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="656"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="686"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="740"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="766"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="19"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL27782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="833" mass="88739" checksum="4D18167FFFADB9EC" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNH3</accession>
    <name>A0A0G4PNH3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S023g000181</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793156">
        <property type="protein sequence ID" value="CRL27723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PNH3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PNH3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="64"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL27723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="591" mass="67007" checksum="D19CE54511825CB4" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNS4</accession>
    <name>A0A0G4PNS4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane ATPase</fullName>
            <ecNumber evidence="10">7.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S025g000170</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O + H(+)(in) = ADP + phosphate + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:20852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.1" evidence="10"/>
    <dbReference type="EMBL" id="HG793158">
        <property type="protein sequence ID" value="CRL28112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PNS4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PNS4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000021">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000030">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000005">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000008">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
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        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
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        <property type="entry name" value="HAD-like_sf"/>
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        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006534">
        <property type="entry name" value="P-type_ATPase_IIIA"/>
    </dbReference>
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        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
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        <property type="entry name" value="HATPASE"/>
    </dbReference>
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        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
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    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="365"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="402"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="758"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="785"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="821"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="885"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="936"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="12">
        <location>
            <begin position="86"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="245"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU362083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL28112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1011" mass="111807" checksum="BFF53607B812643A" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-11-27" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNZ7</accession>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S024g000091</name>
    </gene>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
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        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF2">
        <property type="entry name" value="CHITIN DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
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        <location>
            <begin position="21"/>
            <end position="258"/>
        </location>
    </feature>
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        <location>
            <begin position="56"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL27836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="258" mass="28613" checksum="BE329406B8F3A4B7" modified="2015-09-16" version="1">MHFLAPLFPFLLSAITLSQAAPTGNSINTNTTTNALHPNVSKLPFGAVITHCAIPGTIALTFDDGPYIYTPQILDTLAQHGVRATFFLNGHNRGHIDTSPEVVQRTLAEGHQLGSHTWNHLSLDTLPYEEIVHQMTILEEAFMRILGFFPTYMRPPFLRHTPVVLGAMADLGYHVIGASVDTKDYENDNPDTNWVSFEKFKREVDAGGTIVLAHDAHQYTVEILVDNMLADVERRGLSAVTVGECLGDPSEFWYRTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PP00</accession>
    <name>A0A0G4PP00_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S025g000172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793158">
        <property type="protein sequence ID" value="CRL28114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PP00"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL28114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="105" mass="11723" checksum="D7EE0A36C06EE428" modified="2015-09-16" version="1">MNEHSTSLNTIRCIFVLVIPKKQWPRCPFRCLPPGALSAWYDPHVHASDLKRKGLEPFLGSKWVQIKFYLMPGHRTVRSRIPCHLGGHLGGYFGGHLGGGGTPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPG1</accession>
    <name>A0A0G4PPG1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alpha-galactosidase</fullName>
            <ecNumber evidence="11">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S025g000069</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="11"/>
    <dbReference type="EMBL" id="HG793158">
        <property type="protein sequence ID" value="CRL28011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PPG1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PPG1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF61">
        <property type="entry name" value="ALPHA-GALACTOSIDASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195627" description="Alpha-galactosidase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha galactosidase C-terminal" evidence="13">
        <location>
            <begin position="356"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CRL28011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="436" mass="48082" checksum="4C45CC0AC153A185" modified="2015-09-16" version="1">MLGPLTLAVALPFLPAANALVRKNGVGRLPALGWNSWNAFGCDINSTKVLIAANEVSNLGLKDLGYEYINIDDCWSVKNTRDKSTNRLVPDPSKFPDGISGVAEQVHDLGLKIGIYSSASEVTCAGYPASLGYETVDAQSFAEWGIDYLKYDNCDVSSNWTDTYAYCVPDSDGDHPNGTCPDITNPAPEGYDWKTSKTYQRFSAMRDALLNIDRTILYSLSEWGQADVKTWGNETANSWRMSGDITADWARIAQIANENVFLLDYANFWSYPDPDMLEIGNGDLTIEENRAHFALWAVMKSPLIIGTALDSINDDHLAILKNKYLLDFNQDPVIGSPAHPYKWGYNPDGTFDPVHPAEYWSGASSTLEGTLVLMLNSEDATSTRTARWSEIPELKSHNAYQVIDAWTGKDLGCVKNTYKASLKSHDAAVLVVKGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPN4</accession>
    <name>A0A0G4PPN4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone acetyltransferase ESA1</fullName>
            <ecNumber evidence="4">2.3.1.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Histone acetyltransferase esa1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15 24">protein 2-hydroxyisobutyryltransferase ESA1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 25">protein acetyltransferase ESA1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16 26">protein crotonyltransferase ESA1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">PCAMFM013_S027g000014</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(2E)-butenoyl-CoA + L-lysyl-[protein] = N(6)-(2E)-butenoyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53908"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:137954"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:53909"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] = N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:15921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:131780"/>
            <dbReference type="ChEBI" id="CHEBI:144968"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:24181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:45949"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="4"/>
    <dbReference type="EMBL" id="HG793160">
        <property type="protein sequence ID" value="CRL28325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PPN4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PPN4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106226">
        <property type="term" value="F:peptide 2-hydroxyisobutyryltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140064">
        <property type="term" value="F:peptide crotonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000022">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000002">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF218">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE ESA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <dbReference type="EMBL" id="CRL28325.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
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    <sequence length="518" mass="58996" checksum="0CD76B3F1CCA6758" modified="2015-09-16" version="1"> </sequence>
</entry>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="221"/>
        </location>
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            <end position="476"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="CRL28473.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
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    </evidence>
    <sequence length="1491" mass="168743" checksum="ADA9D51DA0F2E77A" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQR5</accession>
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
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        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="372"/>
        </location>
    </feature>
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        <location>
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            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
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            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
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            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="CRL28730.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="714" mass="80274" checksum="2AD609A7901500E3" modified="2015-09-16" version="1"> </sequence>
</entry>
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    </organism>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <source>
            <dbReference type="EMBL" id="CRL28952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="262" mass="29573" checksum="DD844810B69BAF97" modified="2015-09-16" version="1">MACIQTEVELLQAEVDENDQSFFRLLLNDRNIKYVTINPGLYNADDMCFGPSLVSLLPTLPDGDWNDGLVTENEATGQPHFAHAIRTAFPGVENTWNGTFVDYMEILVGEKLRTGIYEVKCPLFDDVVVAKFARFEWEIPYLESETTAYQWIEGNDIGPRFLGHLTEDGRVIGFLMERIKNARHAGPQDLESCRKTLSRLHHLGIQHGDTNRFNFLIRDSTAVLIDFDSARKCSDQNALLKELEHLPKSLEDSSCRGGGGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRG5</accession>
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            <fullName evidence="2">Str. FM013</fullName>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
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                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL28995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="50" mass="5253" checksum="22E306B2CF79E584" modified="2015-09-16" version="1">MDTAMLTAGGQDITSTTLAESNPDNPGLGDATFKYMVIRTAVNCVTTDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRR7</accession>
    <name>A0A0G4PRR7_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S033g000037</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG4 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CRL29117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PRR7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048682">
        <property type="entry name" value="COG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048684">
        <property type="entry name" value="COG4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013167">
        <property type="entry name" value="COG4_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048680">
        <property type="entry name" value="COG4_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20662">
        <property type="entry name" value="COG4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08318">
        <property type="entry name" value="COG4_m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20663">
        <property type="entry name" value="COG4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00762">
        <property type="entry name" value="Cog4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="COG4 transport protein middle alpha-helical bundle" evidence="10">
        <location>
            <begin position="197"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL29117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="814" mass="89303" checksum="59BFF8EBE1D06ADE" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-11-27" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PT94</accession>
    <name>A0A0G4PT94_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S039g000044</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793172">
        <property type="protein sequence ID" value="CRL29735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PT94"/>
    <dbReference type="STRING" id="1429867.A0A0G4PT94"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF132">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="29"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL29735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="378" mass="41803" checksum="7C3B30D4B6B1E470" modified="2015-09-16" version="1">MTTLSTSRGHQALAVSIVFTTIATFITAVRIFTRAFLVKQMGADDYVILVSLVFSWIFFGLMVGEVYHGMGEHYTAIPASIFKAQMIYFWASVPIYQTSLISTKMSILLQYKRVFSTPRMRLACWIMIGVLAFYGTWTIISAWANCVPLAKFWDPTVPGFCLDKKALWFSNSAIHIITDIVILIYPMPVLKSLQLPRKQKFALMAVFALGGFVLITSVLRLKSLLVISNSDDPTYDNVGAATWSAVECNVAIICACLPGTRAFLSRLLPHIFSTRSNGYRSKTTRPSRNGRNPHTGNGNTQVLASVVGGRDHGSGYDHDLEELSPSGSFNSYTKEPVKEAFAGIKVTTNVTQERSSHSKVAVNDDTGSTNELVKKYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PTR6</accession>
    <name>A0A0G4PTR6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tetratricopeptide, SHNi-TPR domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S037g000018</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793170">
        <property type="protein sequence ID" value="CRL29531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PTR6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PTR6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051730">
        <property type="entry name" value="NASP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019544">
        <property type="entry name" value="Tetratricopeptide_SHNi-TPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081:SF1">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN NASP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10516">
        <property type="entry name" value="SHNi-TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Tetratricopeptide SHNi-TPR" evidence="4">
        <location>
            <begin position="224"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="86"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="408"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="290"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL29531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="449" mass="49069" checksum="03C822CC1C3D5A16" modified="2015-09-16" version="1">MADLQDVQSPVSEQEKRTQLDDLIARAAAKDATKDHDSASELYSQATELQAELNGELSPENADLLYAYGKSLYNVAVSKSDVLGSKVAGEQQPQSGTTSSTNTSSAGSKSTSDSFVQDAIANSMTDKSSSAKRAEREPEPTESKPFFQFTGDENFVDSDDEDEETAEQAEDDEEDDDFANAFEVLDLARVLYLKKLSAAEENDGGKGKSTEVSSDIKHIKERIADTHDLQAEISLEAERFSEAVTDLRTVLELRNSLYPLEDPSVAECHYKLSLALEFASVQQGSEEDGNDKPKVDEEMRKEAATQMEHAIASCKVRMAQEEKKLEAEKDGDEDKATATKRKIANVKEIVTEMEQRLVDLRRPPVSIEQNDQANEAMLKGVLGQIIGQSATDQKAQLDAASKGATDLSAFVKRKPAKQTSHQPETASKRPAEESAENGSKRSRVDDASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PU96</accession>
    <name>A0A0G4PU96_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S044g000011</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793177">
        <property type="protein sequence ID" value="CRL30080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PU96"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033229">
        <property type="term" value="F:cysteine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF63">
        <property type="entry name" value="HIGH AFFINITY CYSTEINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
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        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
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        <location>
            <begin position="58"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL30080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="501" mass="56255" checksum="124B6B30AE7F5E02" modified="2015-09-16" version="1">MAKETEMATVDHEEMKSNSNSADICEDGNEKKDPYMTDPIQMDAATDRRLFWKITRRVLVIQVITYFCQSLDKGILNYASIMGIKSDAHLVGQQYSWLGTILYIGILCGEYPQNLLLQKFPVAKTLAINIFIWGAVVACSAASTNFASLMAVRFLLGFFESCVQPAMMLVTGMWYKREEQSLLNSIWYCMSGVQLIIGGLLGFGVSHFTNGPIKNWQLLFLVLGLFTCVWSIVVGIFLPDSPLSAKCFSEDDKRLMVERVRHNETGIENKKYKKYQVVEALKDPLVWCCVMLILVANLVIGGLGVFSNLIIQKFGFTLLQTQLLNIAQGAWSIIVMIGSAWASQRFQQTCLVMILYTIPSIIGTIVILVVTPTPSNAGGMLIAFYCTQFFPAQGNMIISLITRNIAGQTKKSFTMTMLFIGWSVGNLIAPQIFRDGDAPRYLHGFLTHVIIYAVYIGIVILTRVIIMARNRSKERATSEISHDLAFQDLTDRENPNFRYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUF5</accession>
    <name>A0A0G4PUF5_PENC3</name>
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        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S045g000006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793178">
        <property type="protein sequence ID" value="CRL30140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PUF5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PUF5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41390">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41390:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 213 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="199" mass="21676" checksum="2A878F56988249F6" modified="2015-09-16" version="1">MSGQIKDVQDFQSSSLLSAAKVGALSGTAGLIYGGAAGVIRSPNPMIHSLSCGIHWFACGSAFWWLRSNIIKHHYQDKASLTERTYASALCGGIAGGSVTKLMGGRLVPGAIIFSLLGFCGQSIFNRVDAWQMENAHKTSKPLMQRMAESKWIPLRSLSDQEYREMLSEKLLSIEAEIALLDDKIEELEKSRPVPSSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVB5</accession>
    <name>A0A0G4PVB5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sugar/inositol transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S051g000028</name>
    </gene>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF45">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="442"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="15"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL30425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="516" mass="56900" checksum="4BDE4D44F0E3D9F6" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVK0</accession>
    <name>A0A0G4PVK0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S048g000038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793181">
        <property type="protein sequence ID" value="CRL30326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PVK0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="59" mass="6123" checksum="0B0B2B2569F41ED5" modified="2015-09-16" version="1">MSHNVESIPVDATSSTSSQPMNDVASSQRCAVANCGKWAVAQSRFCADHKPAPAPTCCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PW57</accession>
    <name>A0A0G4PW57_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S054g000034</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CRL30577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="63" mass="6964" checksum="2291FA1D35BFEFD8" modified="2015-09-16" version="1">MVYMTQVAHWFSSNALENVSVKHTKNILDLPSINTSSLRFSPVKVKTSRPLAASAASQWSKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PW58</accession>
    <name>A0A0G4PW58_PENC3</name>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
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                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL30399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="136" mass="15112" checksum="79836963C4FAA23B" modified="2015-09-16" version="1">MIAPDDDLEMMDFQQIHVGPLDRWSLHMAELFAINKYSTSATILCDSISAPKGIQNSATNLTYYHAYHIYTQSPSPSQANGIALYLQWIIGHCDNPRNDATRPAMSFPPTTHKGKGAHPRQHPRSVGTGVEIIHSK</sequence>
</entry>
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    <accession>A0A0G4PX00</accession>
    <name>A0A0G4PX00_PENC3</name>
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        </submittedName>
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    <organism evidence="1 2">
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        <lineage>
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    <reference evidence="1 2" key="1">
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
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</entry>
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    <accession>A0A0G4PX51</accession>
    <name>A0A0G4PX51_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
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    <organism evidence="2 3">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080:SF1">
        <property type="entry name" value="SRR1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="150"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="346" mass="39227" checksum="10A04F22A7F1FBDC" modified="2015-09-16" version="1">MPQTLRPLDYGCTDWRISSQIAADLYSSGTRLWTKEDLEDIEQQLRQSYAMERFSVRRIDGSIIQISNPMFQVPNPIWKPHVKYQEYWQLVKAQPNGPIETYLCSYIVDWSNQTARNFRELLAQPLQVFDEKHLLWQNSKTCKHLAALVQDILGTNTVKKVLCFGLGDFCRSAPEWLKRQHGSWDEDSEVKNVMGCMIQHSMALTIAQLCRGNEKLPLLAQDPDYTEVAEEILTKKGFKIVGTHGAGGFAEIDEESIIISPFAAAPVKQIIADLARPALIISTGFEVFNGNEKPLADAESSRTRQMWLDYDAYSLPSHSDDVEICSALKGLHLYCRRQQTLNAQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PY06</accession>
    <name>A0A0G4PY06_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Lacoste S."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793238">
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    </dbReference>
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    </dbReference>
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            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL31294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="82" mass="9269" checksum="910D9382B8689502" modified="2015-09-16" version="1">MNLGPGDLKYQKDDSDNDNKLSRRSCYKEPKRNHKNILRTSKGLGDTLADAIGGLKEGNAPGFHFYKRAAIWKESAKIYLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PYB9</accession>
    <name>A0A0G4PYB9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
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                <person name="Branca A."/>
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                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PYB9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL31493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="521" mass="58610" checksum="B1C55C8495785833" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PYC0</accession>
    <name>A0A0G4PYC0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polyketide cyclase/dehydrase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S082g000008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793213">
        <property type="protein sequence ID" value="CRL31161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PYC0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PYC0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015075">
        <property type="entry name" value="AtaL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08982">
        <property type="entry name" value="AtaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL31161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="17808" checksum="0A0B819CE0077554" modified="2015-09-16" version="1">MVYLSIARFHHLIPTLSRGKVWNGLKSKARRPQDFIPSFDDSGVIEERDNGSYIVREAHVGANLSESPMAGKWTREECRLHEPAYFTLPGGSIIQNILSEGPDQALYLTFTYEWKLPDIEPGTKEAKRAWHDHMKIAISSVQGTIKALRTMTEVKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PZ75</accession>
    <name>A0A0G4PZ75_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S3Jg000066</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="HG793312">
        <property type="protein sequence ID" value="CRL31455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4PZ75"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02878">
        <property type="entry name" value="GH18_zymocin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029226">
        <property type="entry name" value="Ecp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053214">
        <property type="entry name" value="LysM12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700:SF1">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700">
        <property type="entry name" value="V CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14856">
        <property type="entry name" value="Hce2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="4" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195726" description="chitinase" evidence="12">
        <location>
            <begin position="27"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="13">
        <location>
            <begin position="298"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="13">
        <location>
            <begin position="362"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="14">
        <location>
            <begin position="501"/>
            <end position="872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CRL31455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1470" mass="161124" checksum="CFF94A952F280C38" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NT39</accession>
    <name>A0A0G4NT39_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome c oxidase subunit 4, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cytochrome c oxidase polypeptide IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S001g000207</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase subunit 5B family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NT39"/>
    <dbReference type="STRING" id="1429867.A0A0G4NT39"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00924">
        <property type="entry name" value="Cyt_c_Oxidase_Vb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.11.10:FF:000003">
        <property type="entry name" value="Cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.11.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit Vb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002124">
        <property type="entry name" value="Cyt_c_oxidase_su5b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036972">
        <property type="entry name" value="Cyt_c_oxidase_su5b_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01215">
        <property type="entry name" value="COX5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57802">
        <property type="entry name" value="Rubredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51359">
        <property type="entry name" value="COX5B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
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        </location>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="196" mass="22164" checksum="9B9357F40F944269" modified="2015-09-16" version="1">MFLQRTASALARRSPARAFTLAQRPFSSSIIRSNEKKWTPKQEGKILTFEEIKSEEDLFAPGAKPGTIPTDIDQATGLERLELIGKMQGIDIFDMRPLDASRKGSIEDPIIVNSAGDEQYAGCTGFPADSHQVNWLTVSRERPIERCLECGNVVKMNYIGPEEDPHAHDHDHGHHHPPHVEPKTFADYVKPDYWYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NTY7</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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        </source>
    </evidence>
    <sequence length="134" mass="15231" checksum="02ECF80B7E9AC005" modified="2015-09-16" version="1">MSSAVSIYVAISIGDGVYKHWGIFIDAPREEDKIFLQVAGSDGRFRYELETRDVRQSERLVELLPLYDVDVAEINSIKTVASQVTVHNEIRGWNCQDYVLDVLEALEKEGIVNSKDARYKKQKDLLRGKQEGLA</sequence>
</entry>
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    <accession>A0A0G4NU86</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="229" mass="26306" checksum="09956368EBD238A8" modified="2015-09-16" version="1">MNHTRGLRSSAQALRQIFIAPFRTSRVGILTFRPLQNVPQTRFFQQSRCLELRGYRPPVEKPPMNEAIRASFVQVVNDEGDLDPPTRLEDVLESFDHTEFFLLQVQEGDHENPPVCKIYNKKEVRAHEKAKAKAARESKVVFKQIELNWAIDAHDLSHRLKQLSTFLEKGRRVEILLATKKRKRNPTVDEIKQVMQSVLDTIREAGGTQTKAMEGEPGKQLKITAQKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NUC8</accession>
    <name>A0A0G4NUC8_PENC3</name>
    <protein>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4NUC8"/>
    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
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        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032185">
        <property type="term" value="P:septin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36414">
        <property type="entry name" value="PROTEIN SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36414:SF1">
        <property type="entry name" value="PROTEIN SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL17660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="250" mass="27614" checksum="EB5B7263FADE849A" modified="2015-09-16" version="1">MGLSRATLGFTGLFFMAASILLIFLTLLGGARNSNPLNKIYFLQAETGNIPGASSTSRWTFWNLCGVKDGKNDCGDTHVDFPFDPPSHRNFDTTDNIPSQFIGTNHYFLMSRFMFPFIIIGLFFAVCSFFTGMLAICTRVASYLSGFLAWIALTFQVITTCLMTAVFVQGRHAFNSNGQNSSLGVKAFAFMWTASVCQFLSCLLYCLGGAVGRKDTSSGYSGRKERRRGFFSSQRSNSVKSQKKEATNYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NVF5</accession>
    <name>A0A0G4NVF5_PENC3</name>
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        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">PCAMFM013_S001g001046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
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            <taxon>Eurotiomycetes</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL18086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NVF5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL18086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="99" mass="10996" checksum="99605A31DB6AF8A2" modified="2015-09-16" version="1">MFVMEVPAPTLDIVGHDPRVGWMENIRPQLLPFSSPFNQKNASHTLTVNCGVCGVKWTLSSPLGNTDISHFKLRKPILCYENSPSFQNLSEFSTSNCVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NVL3</accession>
    <name>A0A0G4NVL3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S001g001050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL18090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NVL3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL18090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="247" mass="29053" checksum="550BE4C5DB772BE7" modified="2015-09-16" version="1">MDIQQIRRRLNRLTSFSGPHLVPHETPTTLCPKVIPNEISKTNILNRFKNNRWKYCHCYCQCYQKLYPPPKWHYRFIWPLSRGPCFYAGEVDICPCFSIKFPDLRHLIDMVGSQEKDGPSDRSKYGDYHIFHKLRLDNVRNHMRHNRTQSLRVLTCYAIRGSPDILSQIFANAKALGHKDTAKWLRRTFVEAGSTFSGWHKNSYFLISSNRPEMPKGYEPTLLEISTVRNLGDGQWPNKQWKINVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NVM2</accession>
    <name>A0A0G4NVM2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial substrate carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S001g001065</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL18105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NVM2"/>
    <dbReference type="STRING" id="1429867.A0A0G4NVM2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF2">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G13870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="39"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="161"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="260"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL18105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="489" mass="53218" checksum="99B398EE0ADDC8AF" modified="2015-09-16" version="1">MAEFKLSYESQLDVYHPSYRYEAHDPRDWKSAALRGPALPALGNATAGAVGAAISNVVVYPLNVIVARLQTQNQKQKNGDSSEKSDDDENSDELYTSVVDAARKIYAQQGIAGFYPGLAQDTWKTVADSFLFFLAYSAIRQKRIVAHVGVERAAKSKNIVLPILDELAVGILAGSFAKLFTTPLSNIVARKQTSAARKGGNVKNLSTSDIAARIRAEKGILGFWSGYSATLILTLNPSLTFFLNEFLKRTLLPRSKRDKPSPALTFLLAALSKVAASSITYPFSLAKTRAQVMSSDSKSKSGSADKTRTSLLASLTPEILSTVATIARKDGIPGLYAGLHGEVLKGFFSHGFTMLAKDAVYAFIVKTYYLLLLLGRRYPSPDELIQRAREQAEEYTEIAREGARDLAERTREGAEELLNANSGGNAVDMTSNSAGAADASSGLKVPASSVSDELNETAELVGDYVEDEAAEWKSLYHWFWEKDRGPHHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWS0</accession>
    <name>A0A0G4NWS0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S002g000371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWS0"/>
    <dbReference type="STRING" id="1429867.A0A0G4NWS0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL18501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="345" mass="39173" checksum="7D6E623D8DC58DF1" modified="2015-09-16" version="1">MAKPDLRGVTPEFTCALNARDIMSVPKEDTLRALVQRYPDMLYHAARVCAIAGYIDLYEELDPLPEVHVAEEAGYASMQKSSNGSQQIYHYILSQPVNFEIMNDYTRTVNIAGCRVASLNGDTAAYSSLSARSKYYGPREVKSDSRSWDRFYTDPYYFNITGDWGIYDHDCKGPKAPEDYLPLVPQMLEHEWAMVIHEKCEIKIKCAINARRIMSNDLSWLTADTPGKLLPDLIWYPAVAHCLTCEKLAHMRPDMFGRCVRACIVANDPMSWDDLLRAAPGIFKSTRDPSDPEDPKLWWLFKHADYGLWNEAATSSNKSLQQDISEAVPDASEKFRAPHNNSDWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NX15</accession>
    <name>A0A0G4NX15_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">nitrilase</fullName>
            <ecNumber evidence="4">3.5.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S002g000455</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a nitrile + 2 H2O = a carboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18379"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="EC" id="3.5.5.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.5.1" evidence="4"/>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NX15"/>
    <dbReference type="STRING" id="1429867.A0A0G4NX15"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000257">
        <property type="term" value="F:nitrilase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07564">
        <property type="entry name" value="nitrilases_CHs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000132">
        <property type="entry name" value="Nitrilase/CN_hydratase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF14">
        <property type="entry name" value="ARYLACETONITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00920">
        <property type="entry name" value="NITRIL_CHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00921">
        <property type="entry name" value="NITRIL_CHT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CN hydrolase" evidence="6">
        <location>
            <begin position="5"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00036406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL18585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="325" mass="36333" checksum="1F0F546024513946" modified="2015-09-16" version="1">MGQQVRVAAVQAEPVWNDLEGGVQKVISIIDDAAKNGANVLGFPEVFIPGYPWTMYANSPYSNGDFFLEYLRNSMSKDSAEMKRICDAVKRAGIFVVLGYSERDNGSMYISQAFINTEGEIIHNRRKIKPTHVERAYWGTGEGDSLKSVVPTSFGRVGGLNCWEHTQPLLRYYEYEQDVDIHVASWPAVWERPAELKGKWPYSIGGTMSQRISQCLAFEGACVVLVCTQVISEQNAEKNRIVGWPYPQLPGGGFSMIFGADSEPLCEPLPAGTEGILYADIDLEDKMKSKQFLDVVGHYSRPDLLSLRVNKHPSRPVHYANDNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NX65</accession>
    <name>A0A0G4NX65_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldolase-type TIM barrel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S002g000516</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DapA family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NX65"/>
    <dbReference type="STRING" id="1429867.A0A0G4NX65"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008747">
        <property type="term" value="F:N-acetylneuraminate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020624">
        <property type="entry name" value="Schiff_base-form_aldolases_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42849">
        <property type="entry name" value="N-ACETYLNEURAMINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42849:SF1">
        <property type="entry name" value="N-ACETYLNEURAMINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00665">
        <property type="entry name" value="DHDPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="4">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL18646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="280" mass="29101" checksum="825663B212326768" modified="2015-09-16" version="1">MASLHGILVALITPFTDDKTAIDESRLQAHIEHLIKAGVHGLVPGGSTGEFTTLTVAERKQLTELCVKFAAGRVPVVAGTGSLSSAEAVELSVHAAQVGAASDNGRAPIHTASGLPIVFYNIPAASGITLSPTEIAGLSKVGVKYLKDTSGNAPALTELIFGLSDQITSFNGWDTLTFYGLAAGAPGGVWGAANIIPELAVELYEAVSVKGDLKLGREIWAKAWPICKFLEAHSYAAAVKTGVELIGQPTGGLRKPFALLNPELTAELKQLLQKAGVKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXG2</accession>
    <name>A0A0G4NXG2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S002g000678</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NXG2"/>
    <dbReference type="STRING" id="1429867.A0A0G4NXG2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL18808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="282" mass="30124" checksum="E43A1B6AEA79FC79" modified="2015-09-16" version="1">MARTVLITGCSDGGLGASLALAFHAAGLKVYATARNPSKLDQVSSAGIETLTLDVLTSESIKNAVTKLPNLDILVNNAGAEYLMPVADVDIADAKRLFDLNVWSYIEVTQAFLPLLLKSPHGGLIVNQSSVGSVAVLPFQGVYTASKAAIAMLSDTLRLELGILGITVVDLKTGVVRSNLIKNQKEAKPPTLPEKSIYYPAREVVEKALSQDAFAEGGMPTLQWATAVVGDLLKKKPPPVIWRGEQAWIVRLISVLPFGMFDGMLKKLTGLDVVEQIMKVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXQ3</accession>
    <name>A0A0G4NXQ3_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S002g000634</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NXQ3"/>
    <dbReference type="STRING" id="1429867.A0A0G4NXQ3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14518">
        <property type="entry name" value="DSP_fungal_YVH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000104">
        <property type="entry name" value="Dual specificity phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016278">
        <property type="entry name" value="DUSP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848:SF4">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000941">
        <property type="entry name" value="DUSP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="2"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="68"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="5">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000941-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL18764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="354" mass="38518" checksum="12A5CF31069CDD9F" modified="2015-09-16" version="1">MAMNQIKGHNIYVGGILSAKNKAALARADISHVLSVLRLNPAEEQETFKSFQHLSIGVDDVDDENLLEHFPAAIKFIQSGLNGGGGVLVHCAMGKSRSAAICIAYLLHRQPGALTPQSALALVRQSRPLCEPNEGFMEQLNLYHEMGCPDDVTDHPSYKRWLYRRDVEGSVACGRAPELRSVRFEDEQPVQSQAATGRTVEIKCRKCRTKLATTPFIIPHEEEKQNTAKSSATAECGHVFLHPLTWMRPSLFPSEDGAEATADTTYGAHPDDAPLSGRLTCPNPICGSNVGKFAWQGLRCSCGGWVVPAIGLTKARVDIAYQVNMAQGVRANPAIRLPPGMRVPAVDDSERGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXZ2</accession>
    <name>A0A0G4NXZ2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S002g000832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NXZ2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL18962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="107" mass="12400" checksum="7085887644685828" modified="2015-09-16" version="1">MDEATVNLQADHHVELIMRDAVLFSREAHLHVALRANLNTINVTQNELRLLLALSNQQRRYLNSNVEQMGDHLEELGTHRPQLRTDYDHTRAQRADIAEFIHELLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NY17</accession>
    <name>A0A0G4NY17_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sugar/inositol transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S002g000734</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NY17"/>
    <dbReference type="STRING" id="1429867.A0A0G4NY17"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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            <end position="69"/>
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    </feature>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
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</entry>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
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        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
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    </comment>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="468"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU364149"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF11635"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20719"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL19217.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="932" mass="102750" checksum="2838B88D41ED969D" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P198</accession>
    <name>A0A0G4P198_PENC3</name>
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        <recommendedName>
            <fullName evidence="5">U3 small nucleolar RNA-associated protein 22</fullName>
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        <name evidence="13" type="ORF">PCAMFM013_S004g000030</name>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
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                <person name="Silar P."/>
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                <person name="Giraud T."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the NRAP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4P198"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="175" mass="19212" checksum="4618C53E4F21ADB6" modified="2015-09-16" version="1">MGLRGVQLGLRAWEFLWTLLIMALIGNMIAEAFSGNPATVNYAIYVAVFSMFTLIYLIPASFNIDWAGHPIIMIIVDALNCVFFFCAAIALAAKLECHSCNNQDYLRNNEITNGSNNMTKRCREAQASVAFLWFAWAGFLASVVVSVFMSRSAAGPSRASRAGSRRGGRPNMTQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P283</accession>
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        <recommendedName>
            <fullName evidence="5">Endoplasmic reticulum-Golgi intermediate compartment protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="8" type="ORF">PCAMFM013_S004g000293</name>
    </gene>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
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            <location evidence="5">Endoplasmic reticulum membrane</location>
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        <subcellularLocation>
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            <topology evidence="5">Multi-pass membrane protein</topology>
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        <subcellularLocation>
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        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
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        <text evidence="5">Belongs to the ERGIC family.</text>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ER-DERIVED VESICLES PROTEIN ERV41"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ERGIC_N"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
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    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="7">
        <location>
            <begin position="23"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="6">
        <location>
            <begin position="190"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL20353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="396" mass="44776" checksum="624B3D6EA774BA3A" modified="2015-09-16" version="1">MNGFESKGLNEDAFGEKSSLAALKTFDAFPKTKAAYTTPTRSGGQWTVLILLICTVFSWSELKTWWRGTENYHFSVEKGVSHDLQLNLDMVVHMPCDQLRVNIQDAAGDRILAGELLKRDDTNWLLWMEKRNYEISDGAHEYQTLSHEETDRLAEQEADAHVGHVLGEVRHNPRRKFPKGPRMRRGVVPDACRIYGSLEGNKVQGDFQITARGHGYRENAPHLDHSSFNFSHMITELSFGPHYPTLQNPLDKTIAEIEDHYYKFQYFLSIVPTLYSRGKGALDAYTRSPETAAARYGRNTVFTNQYAATSQSSAIPESPMVVPGIFFKYNIEPILLLVSEERAGFLSLVIRVINTISGVLVTGGWLYQITSWAGDIWGRRKNRSSEGYLTGKPSMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2I6</accession>
    <name>A0A0G4P2I6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Epoxide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S004g000460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P2I6"/>
    <dbReference type="STRING" id="1429867.A0A0G4P2I6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF39">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="4">
        <location>
            <begin position="17"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL20519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="396" mass="44514" checksum="7E8EF6AAE47C0920" modified="2015-09-16" version="1">MSLPFSTLPSTATASLTPFQATIPKAKLVELETLIKLAKLAPTTYENSQTDRRYGVTTDWLVTMRDQWLRSYHWKSSEDRINSFPQYTTEIEGLAIHFVGLFSERKDAVPILLLHGWPGSFLEFLPILQKFREEYTPETLPYHLIVPSLPGFTFSSGPPLDRDFGTGDIARVVDQLMKGLGFESGYVAQGGDIGSRIARHLGVDHESCKVNVVFMRKPDGMTDDHLNALEIKGIERMTNFIATGAGYATEQGTRPSTIGHVLSSSPMALLAWIGEKFLEWVDDPLAPEDILESVTLYWLTETFPRAIYTYRQNYPSPPVPASNDPRWYIHKPFGFSSFPMELAPLPCSWVETTGDLVFWKQHKKGGHFAALERPDELKADLVKFVDQVWPGITGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2I8</accession>
    <name>A0A0G4P2I8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Interferon-induced Mx protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S004g000482</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P2I8"/>
    <dbReference type="STRING" id="1429867.A0A0G4P2I8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF149">
        <property type="entry name" value="GTPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GED" evidence="4">
        <location>
            <begin position="619"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="917"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="917"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="933"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL20541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="942" mass="105991" checksum="B1B5CC1AA28CE4B6" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P355</accession>
    <name>A0A0G4P355_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S004g000706</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P355"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF59">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
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</entry>
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                <person name="Dupont J."/>
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            <dbReference type="PubMed" id="24407037"/>
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            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
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    <sequence length="581" mass="63276" checksum="0F075ED5EAC95788" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3S7</accession>
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        <submittedName>
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        </lineage>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="entry name" value="Autophagy protein Apg6, putative"/>
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    </dbReference>
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    </dbReference>
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            <end position="288"/>
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            <end position="138"/>
        </location>
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            <end position="294"/>
        </location>
    </feature>
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        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00005965"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF17675"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL21000.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="529" mass="58046" checksum="D281E2EDB335ECFB" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P430</accession>
    <name>A0A0G4P430_PENC3</name>
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        <submittedName>
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        <name evidence="4" type="ORF">PCAMFM013_S005g000249</name>
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        <lineage>
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            <authorList>
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            <dbReference type="PubMed" id="24407037"/>
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                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P5U2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="38"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL21662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="364" mass="39967" checksum="8FC74D47104A4D4B" modified="2015-09-16" version="1">MAPPSDTLVHSLGHNTLGKIDIAVQSVLLAIVFVFVGLRLWSRRLQWVSLQLNDFLIIVATFFMVGRYVVEIVVVVLCGMGLHSTEVTQVGGSEAFVQFNQLTYAGDLLWVTVIALVQLSVLSYYVHSFGQRTITLLAYVLVGLCSALWVAGFFATAFFCTPPKRIWVADTPGHCGDRKMLHTGVNASEAILSFFVVILPIPLIWDMSLSKTRKTSLACIQALGLGIVAIIAIRMKIEFDLDPEDPTHGSARKSILSCIAPLLGIIVACLPTLEPAIQRIFRISALPSPAHTSIYDPTFARYWKTTVLSGRGMEEPEMPLVTLTQPFMTKMGYLAPGGIQVTSHWEIHSSRGSGRLDRSPVRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5V2</accession>
    <name>A0A0G4P5V2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aminotransferase class-III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S006g000240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P5V2"/>
    <dbReference type="STRING" id="1429867.A0A0G4P5V2"/>
    <dbReference type="UniPathway" id="UPA00078"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004015">
        <property type="term" value="F:adenosylmethionine-8-amino-7-oxononanoate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004141">
        <property type="term" value="F:dethiobiotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03109">
        <property type="entry name" value="DTBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001677">
        <property type="entry name" value="Bifunctional dethiobiotin synthetase/adenosylmethionine-8-amino-7-oxononanoate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000122">
        <property type="entry name" value="Bifunctional dethiobiotin synthetase/adenosylmethionine-8-amino-7-oxononanoate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000080">
        <property type="entry name" value="Bifunctional dethiobiotin synthetase/adenosylmethionine-8-amino-7-oxononanoate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00336">
        <property type="entry name" value="BioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004472">
        <property type="entry name" value="DTB_synth_BioD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42684">
        <property type="entry name" value="ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42684:SF3">
        <property type="entry name" value="ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13500">
        <property type="entry name" value="AAA_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL21700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="875" mass="96060" checksum="FF834F6AFB2D4079" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-11-27" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P690</accession>
    <name>A0A0G4P690_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acireductone dioxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Fe(2+)-requiring)</fullName>
            <shortName evidence="11">ARD'</shortName>
            <shortName evidence="11">Fe-ARD</shortName>
            <ecNumber evidence="11">1.13.11.54</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Ni(2+)-requiring)</fullName>
            <shortName evidence="11">ARD</shortName>
            <shortName evidence="11">Ni-ARD</shortName>
            <ecNumber evidence="11">1.13.11.53</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ADI1</name>
        <name evidence="12" type="ORF">PCAMFM013_S006g000362</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:49016"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.53"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="11">Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the acireductone dioxygenase (ARD) family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.54" evidence="11"/>
    <dbReference type="EC" id="1.13.11.53" evidence="11"/>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P690"/>
    <dbReference type="STRING" id="1429867.A0A0G4P690"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010308">
        <property type="term" value="F:acireductone dioxygenase (Ni2+-requiring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010309">
        <property type="term" value="F:acireductone dioxygenase [iron(II)-requiring] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Salvage_MtnD_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004313">
        <property type="entry name" value="ARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027496">
        <property type="entry name" value="ARD_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418:SF0">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03079">
        <property type="entry name" value="ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11 12" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="3 11" id="KW-0533">Nickel</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL21822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="193" mass="22138" checksum="724C6A7FF60480AC" modified="2015-09-16" version="1">MKAYWYDNVEVNTFQLAVPGVSKHFQGDQREPHDSGRAVSEEKLASLGVLYKHCPTIAAVDAIAAERGYRNRDEVCVSPATMGAIYEEKVKSFFSEHLHEDEEIRYILDGEGYFDVRGQEDEWIRIDLVKEDMIILPAGIYHRFTTNEQNYVKAMRLFQDEPKWTPLNRGAEVDVNPHRKTYLETVVSPTAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6G1</accession>
    <name>A0A0G4P6G1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cohesin loading factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S006g000445</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SCC4/mau-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793139">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4P6G1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019440">
        <property type="entry name" value="MAU2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21394">
        <property type="entry name" value="MAU2 CHROMATID COHESION FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10345">
        <property type="entry name" value="Cohesin_load"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="302"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL21905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="961" mass="106581" checksum="5CB40776E909664B" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6K6</accession>
    <name>A0A0G4P6K6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Taurine catabolism dioxygenase TauD/TfdA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S006g000503</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P6K6"/>
    <dbReference type="STRING" id="1429867.A0A0G4P6K6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="2">
        <location>
            <begin position="44"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL21963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="309" mass="35602" checksum="E808F718E4E10B9B" modified="2015-09-16" version="1">MRFLRVPLNRIDQSVRKLHSSPHLLPPRGSRCLSFDHAPSIPELDAHDLVSIENKGHVRQVHDYLRSHGALKVKLGFLDPDSDYLYQLVLSLHKNHGHGLPSTHSLTKGWFWDVRPQPETIEHRAISETMSNFPWHTDSCYETAPAKFFALHVLQHDRFGGGTLSLLNVDRLLHSISPWAKLALSEPEFRIAVPPEFSKGNQESFIGSLLSTDEQGQHVRLRFREDIVRPLTPRANSAYDELMNAFFQHKKTKIQNLRSEALPQGSIILMDNGRWLHSRNHVRDPGRHLRRVRWDARPFQKHSGHFAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6N7</accession>
    <name>A0A0G4P6N7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S006g000532</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P6N7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL21992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="63" mass="6812" checksum="D61282E1A27D1193" modified="2015-09-16" version="1">MFLATSFAEPKLSELVPTLTGESNFASWSTALKCALDTRDPRLFDVLTGNIAQLAPEDPALTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6Y1</accession>
    <name>A0A0G4P6Y1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome c</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S007g000084</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="12">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the cytochrome c family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P6Y1"/>
    <dbReference type="STRING" id="1429867.A0A0G4P6Y1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000001">
        <property type="entry name" value="Cytochrome c iso-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002327">
        <property type="entry name" value="Cyt_c_1A/1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11961">
        <property type="entry name" value="CYTOCHROME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00604">
        <property type="entry name" value="CYTCHRMECIAB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 10 12" id="KW-0349">Heme</keyword>
    <keyword evidence="9 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="7 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="13">
        <location>
            <begin position="12"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CRL22103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="114" mass="12461" checksum="421DC21BAB58B59A" modified="2015-09-16" version="1">MPPKKQESFAPGDAAKGAKLFQTRCAQCHTTEAGGPHKVGPNLHGLFGRKTGSSEGYAYTDANKQAGVEWNETTLFSYLENPKKFIPGTKMAFGGLKKTKERNDLITWLKDNTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P758</accession>
    <name>A0A0G4P758_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S007g000118</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P758"/>
    <dbReference type="STRING" id="1429867.A0A0G4P758"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL22137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="292" mass="31795" checksum="34C3A1A4FF0393A7" modified="2015-09-16" version="1">MAQADHTGINFTSRSHHDTYPAIDPTKRDLSSKYIFITGASKGIGRETALSYSRAGCAGIAVGARSNLSGLAASISEAASEAGKPVPQIVVVSLDVTEEKSVAAAAATVNEAFPRLDILINNAGYLEKRAKIADSDPEEWWRTWDVNVRGPYLVTRAFLPQILKGGEKIIVNLSSIAAHLLSPGGSAYQTSKLALQRWTEFLDADHGPDGILTFGVHPGGVLTDMGKRLPVETQVVLTETPRLCADTLVFLTESRREWLAARYISVTWDMEEFLSREEEIVQGDKLKVRMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P781</accession>
    <name>A0A0G4P781_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleolar, Nop52</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S007g000157</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P781"/>
    <dbReference type="STRING" id="1429867.A0A0G4P781"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010301">
        <property type="entry name" value="RRP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026">
        <property type="entry name" value="NNP-1 PROTEIN NOVEL NUCLEAR PROTEIN 1 NOP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05997">
        <property type="entry name" value="Nop52"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="131"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL22176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="316" mass="36440" checksum="10ABBAD24F0E3FAA" modified="2015-09-16" version="1">MDGQKTPFVRELGSSDRKVRDKALESLTKFVQSRTDLTLVDLLKLWKGLFYCFYHSDRPLTQQALARALSYSLVPSLPQATLHRFLRAFWITIGRDYHSLDRIRLDKYLMLIRCYVGVAFEVLLKNKTSTKNADGKKRKREDAAKQGRGKKQKKQAEAETVEDEEEKDSAEDAEAKFPDLAAYISIIEEGPLCPLNYDEDQAPDEGDPNYVPMPHGPDGLRYHLIDIWVDELEKVLEFEEVAGDEDEETPKRKIKGDVPIELILRPLEKLRAESAYKPVRTRAAEALEDERLFEWGVRTRKSEEDDDSEEEWGGFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7C3</accession>
    <name>A0A0G4P7C3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alanine racemase, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S007g000145</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DSD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P7C3"/>
    <dbReference type="STRING" id="1429867.A0A0G4P7C3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008721">
        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036088">
        <property type="term" value="P:D-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.20">
        <property type="entry name" value="D-serine dehydratase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051466">
        <property type="entry name" value="D-amino_acid_metab_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026956">
        <property type="entry name" value="D-ser_dehydrat-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042208">
        <property type="entry name" value="D-ser_dehydrat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004:SF2">
        <property type="entry name" value="D-SERINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004">
        <property type="entry name" value="ZGC:162816-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14031">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01119">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-serine dehydratase-like" evidence="3">
        <location>
            <begin position="310"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL22164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="446" mass="48984" checksum="2BBB86F9D8779B80" modified="2015-09-16" version="1">MPSITPSQEDLQKFYIGKDISDVPKPAAILDVAIIRRHCEKMLRTIKTLDVGFRVHVKSHKTPEIAKLQIGDSTEANFIASTVLEIEMMIPLLQDLRHKGCKTNILYGIPLVPSQVPLLAKAARELGKNTITVMIDHPDQLPYLEKLSSLAGHPTCVFVKVDTGYHRAGLPPVSLNKHGLLEKLASAEETGGARLLGLYSHSSLSYSGTTPEQAMGHLISEIRGCKDALERNLHLLPKRELVISVGATPQVVSSQNLLREDSPCAEAQELKALLRETNVELHAGVYPILDMQQFSTNASADSGVLEDEIAISVLTEVCSVYNDGEREKPEALLAAGTLALGREPCPSYSGWGVVSSWRLDGLGKASSERLVVERISQEHAIVTWESESQTKIPLRIGQVVKVHPNHACVTGAFYGWYFVFDSDQDSETSRIVDVWVRARGCGMRAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7E1</accession>
    <name>A0A0G4P7E1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carotenoid oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S007g000239</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P7E1"/>
    <dbReference type="STRING" id="1429867.A0A0G4P7E1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF89">
        <property type="entry name" value="CAROTENOID 9,10(9',10')-CLEAVAGE DIOXYGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL22258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="502" mass="57021" checksum="407EC27CFB6A5311" modified="2015-09-16" version="1">MSVLSQNPRKAFPNRPQFSGFMKPCRVEGEVLNLEVYGEIPKDIDGTFYRVMPDPQFSPFIENDPWFNGDGSISAFTIKDGSVSFKQRFVRTEKFVREQEAQRALLGKYRNKFTDAVEFKIRTTANTNVVHFNGKLLALKEDAPPYALDLHTLETTGLYDFDGQLPSLTFTAHPKFDPRTGEMLCFGYEAKGDGTPDICYYRIAPDGKFMETVWLTAPVLAMIHDFAVTENWVVFPIIPQLCDIERMKQGGEHWQWSPETPFYIGVLPRRGAKPSDLKWFRYQNSFPGHVANAYEDEFGNVILDLGLSETNVFFWWPDAQGKSPEPSSIHSQLTRFTLNPKSEELDLVNPTVLQSDNSEFYRIDDRFTAKPYKHCFFDLMNPALGTDFPTIMPQLGGGYPLYNALAHLNIETGVTEIYFPGKTHMVQEPVFIPRRGSSIEGDGYVMALVNNYVSMCSELHLLDTREFTRAQAVILMPLRLRQGLHGNWVEGDDLQAGAYCGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P8S6</accession>
    <name>A0A0G4P8S6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S008g000108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P8S6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL22679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="96" mass="10563" checksum="4F1909E8C013AD28" modified="2015-09-16" version="1">MAQLQSDIYPSSSHFLDGRATEPAAQYKDPPNTPIPRLIQSVTPDADQLEKLLVRLISGVHTFDPSCSLLSTPKSTSDEATKGRGLGQDQMFQYQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P8Z1</accession>
    <name>A0A0G4P8Z1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoside phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S008g000196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        </location>
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        </location>
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            <begin position="9"/>
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        </location>
    </feature>
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        <source>
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        <source>
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        </source>
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        <source>
            <dbReference type="EMBL" id="CRL22767.1"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="1008" mass="112361" checksum="777462235B336E84" modified="2015-09-16" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="323"/>
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        <location>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="340" mass="38286" checksum="916C23C059D27F09" modified="2015-09-16" version="1">MSARALHGVETYFTVTMEDSYESKIAREDFEPETVFHEVATLANELSDLFKTELTPRQEAAFENHILHSLAWMVYGSNKIEKAGSSSDITLKLCVAVFRGEEIPEEIEEQDQEYLSLKESLIHQHLPADTTAVLRSRREVVQHAKAAKFMMDQLCIRGQDLSEQIILEAHRILTYKVDAETTPWTEYSGVYRSHEVSAGLHAFPHPSLVPYKMKSMFHELKRDLKEVTTSGTIDPIALASKYAHIFVNIHPFIDGNGRMCRLILNSMLLKFGAFIACIGVDEDDRSIYVDVAVNGGALEDLYEDAEEEETPKLYKELASYVLAHVKKSMAGLVSAVANEV</sequence>
</entry>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL22941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="365" mass="41126" checksum="FC155574284531D3" modified="2015-09-16" version="1">MNGLTITPFIANLPKVELHVHIEGTLTPSLRWELAHRNKISLPYATFSDLQASYAVTLNHRPELNGRQPGIPTFLEAYFAGCEVLRTETDFYDLAMAYLRRCAAMNVRYTEPFFDIQAHTRRGVPAAAVMDGYLRAKHDAAAQLGVHSRWILCFLRDEPVEQGLDAYREARPWAAGTVEGGKGLFHAVGLASNAYERPPMLFEEGFSLARADGLHVTMHCDFGQKDTREHVTEAIFEVCGGKGAERIDHGLDAEDSEELWRGLVDRGIGLTLCPHAYHRRTATEVLFLKIRRLVERGVKICINSDDPTLMHDVWIDGNLQKVYTYCGFSRGEMVQLARNAVDMCWAEEDIKRAIYQELDGVDISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P9H0</accession>
    <name>A0A0G4P9H0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S008g000390</name>
    </gene>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
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    </dbReference>
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        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Dupont J."/>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="23"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL23268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="614" mass="70387" checksum="8748A40B7C38DFBD" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAV9</accession>
    <name>A0A0G4PAV9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isochorismatase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S009g000397</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PAV9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00431">
        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF1">
        <property type="entry name" value="ISOCHORISMATASE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="3"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL23457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="189" mass="20772" checksum="84E19188834FE69F" modified="2015-09-16" version="1">MATVLLILDVQNGVIDRLENTEPYLERLASTVTAARKANVKIIHVVTAFRPGYPENNANNSSVPSVVARGEYLEGHSSVQVHPTIAPASGEVVLTKRRVSAFFATELDLLLRCANAQSIVVAGLITSGAVLSTVRQAMDLDYRITVLEDCCMDRDEELHRVLMEKVFARKTDVVSAKEWAEKTSNVPQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PB79</accession>
    <name>A0A0G4PB79_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein-sorting-associated protein 25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ESCRT-II complex subunit VPS25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S010g000021</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS25 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PB79"/>
    <dbReference type="STRING" id="1429867.A0A0G4PB79"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000141">
        <property type="entry name" value="vacuolar protein-sorting-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.570:FF:000003">
        <property type="entry name" value="Vacuolar protein-sorting-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.570">
        <property type="entry name" value="Winged helix' DNA-binding domain. Chain C. Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008570">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014041">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05871">
        <property type="entry name" value="ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL23583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="202" mass="22972" checksum="919350B3CD10346F" modified="2015-09-16" version="1">MTTITPFPFPPTYNFPPFFTPQPNTTTRQSQLEKWSSLIQSWCRHHRQYRLSLIEAVETPLFHNTALRKRLDLRDAREVIDWMTKSEEEGGGGRRAEWISDASGVSSSVSLNGGAGQGLKTVAWIWWRRPEEWADVLVEWVESTGQRGSVLTVYELIHGEGAMSQEFHGMDTDAMLRSLNVLVKRGRAQIFGGEGQEGVKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PB82</accession>
    <name>A0A0G4PB82_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S009g000469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PB82"/>
    <dbReference type="STRING" id="1429867.A0A0G4PB82"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF5">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="548"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL23529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="603" mass="67741" checksum="6C7BB790ABCAB9CA" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBE9</accession>
    <name>A0A0G4PBE9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S010g000074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PBE9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL23636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="77" mass="8858" checksum="66E5AED122391A5E" modified="2015-09-16" version="1">MCSVYTRLILNQSPSHIVFWFHIFLSPTHSDTLVGKRLDPSLRVSPGNLESDAPMKLSCPRYTSLETLQKRRRGRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBG7</accession>
    <name>A0A0G4PBG7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pyridoxal phosphate-dependent transferase, major domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S010g000073</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PBG7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PBG7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050596">
        <property type="entry name" value="AspAT/PAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383:SF1">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="106"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL23635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="482" mass="53552" checksum="1F71BFAA5E387622" modified="2015-09-16" version="1">MSFSGRRLSILRPSENRRLSTTKDLTDNELRSETHRQFRAAHEGHRPHAGLDASRASTGVVWCTERASEHGYAEDPTGWANLGQGAPEADDEIEGSFPRPTSIPITSAAREYGPTAGIKPLRAAVARLYNDHYRQGKESQYTWENVCIVPGGRAGLIRIAAILGNSYLSFPIPDYSAYSEMLTLFKNIAPIPLPLSKDDHYHIHPNKIAEEIARGTQVLLTSNPRNPTGHFVPQEELVEIQDLCRDRATLILDEFYGGYNYTTGCDGSTISGAANVVDVNKDDVLLIDGLTKRFRLPGWRIAWVVGPKDFVDALGSAGSYLDGGANVPFQEAAIPMLEPSLVRTEMQALQSHFMEKRDYVLGRLYDIGFRVQDIPGATFYIWLDLTSLDPPLPPQANISDGLNFFNALLSEKVIVVPGIFFDLNPAKRRDLFDSPCHHFVRLSYGPKMDVLKMGLDGIERVVKRARELGVSKWEDEVAVSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCF8</accession>
    <name>A0A0G4PCF8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S011g000004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PCF8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL24010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="153" mass="17290" checksum="7279E0EE4042334C" modified="2015-09-16" version="1">MLRHSEPLQSLFGRVIGDPTHRLECIWAKDDGARCRNTVPKISRINGALCLGMFHDFPVSCSYEMRLSMAAKYMLCAECSRHSSRSRDCAQRWMKLLLARANRVEQTTQIQQDGHSSTLPVNRWPSSMPYNAGTTEFILPASPSYHPVYGKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDK3</accession>
    <name>A0A0G4PDK3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Berberine/berberine-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S011g000328</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PDK3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PDK3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195370" evidence="6">
        <location>
            <begin position="22"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="117"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL24334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="599" mass="64586" checksum="8721E14BA6AAFF09" modified="2015-09-16" version="1"> </sequence>
</entry>
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                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-acetyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-acetyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="6"/>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL25021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PFE5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PFE5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017328">
        <property type="entry name" value="Sirtuin_class_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF14">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE HST2-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037938">
        <property type="entry name" value="SIR2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="11">
        <location>
            <begin position="10"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 10">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="38"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="48"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="120"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="214"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="238"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR037938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL25021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="342" mass="37417" checksum="CD1DE35EA683C1AD" modified="2015-09-16" version="1">MSDNASDHTKVSMKPDIQSIVDRIKAGKVTRIVVLTGAGISTGAGIPDFRSPNTGLYDKLAPLRLPYPEAIFHINYFSHTPEPFYAIARARHPGNLKPTVTHAFLALLAKKNLLHFLFTQNIDGLEQDAGVPRDKVLWAHGNWKSQHCYKCNSPYPDDLMNKAILAGEVPYCLESGCGGAVKPDVVFFGQALPAEFDEKEKEVLEADLMLVMGTSLRVAPCSRLPGLVKEGIPRVLINNEKAGDMGNRDEDVCILGSCDDGVRQLADALGWGEDLDSLWKEAVTAKKDEDVFEGGPSLDECIEKLASSMKDKMKVSDGHKRMLENHLNNKFGQMIAKGPASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PFH0</accession>
    <name>A0A0G4PFH0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD-binding, type 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S013g000295</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL25052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PFH0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PFH0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF53">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195299" evidence="5">
        <location>
            <begin position="19"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="82"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL25052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="512" mass="55117" checksum="B9824883A27028CA" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGY8</accession>
    <name>A0A0G4PGY8_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="5">PARP</shortName>
            <ecNumber evidence="5">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S015g000174</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+).</text>
            <dbReference type="EC" id="2.4.2.30"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="5"/>
    <dbReference type="EMBL" id="HG793148">
        <property type="protein sequence ID" value="CRL25588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PGY8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PGY8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        </location>
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            <end position="114"/>
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        </location>
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    </evidence>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL25588.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="613" mass="68718" checksum="47A457DB8532A6C7" modified="2015-09-16" version="1"> </sequence>
</entry>
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    <accession>A0A0G4PGZ2</accession>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="CRL25616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="106" mass="11977" checksum="0C066AB824550C4F" modified="2015-09-16" version="1">MYIVKVGIKRQEFCRATFEVFTYIMPETAAFPPVILGVQPPLARQFKPRVARAKAPKKVCQDRDTVHLGTGKRWTAILRFKLAVVISLCRISVKRIAKNKTVPLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PHA6</accession>
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        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Serine/threonine-protein kinase atg1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCAMFM013_S015g000223</name>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
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    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
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                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM 013</strain>
        </source>
    </reference>
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        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="HG793148">
        <property type="protein sequence ID" value="CRL25637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PHA6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PHA6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000693">
        <property type="entry name" value="Serine/threonine protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="21"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="441"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="441"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="543"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CRL25637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="641" mass="72216" checksum="9052F299CA08B9E8" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PHE1</accession>
    <name>A0A0G4PHE1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S016g000081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <text evidence="1">Belongs to the tpcK family.</text>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="13"/>
            <end position="107"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL25800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="121" mass="13661" checksum="BBE9885679398AA7" modified="2015-09-16" version="1">MVYRVIVFASRKSAITHEEFKARYEQHMRMVAEICGDAAPLSHTRSYLKHDAESTPMLLAGSVNETYDAVVTMSFEDEAAFGRFCLALNTPEAKAMIEADEAGFWDQERMKVMVVEDTKTS</sequence>
</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Dupont J."/>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0677">Repeat</keyword>
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            <begin position="8"/>
            <end position="81"/>
        </location>
    </feature>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="822" mass="90949" checksum="001422311FF05CE7" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="25" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <authorList>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL26036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <sequence length="343" mass="39211" checksum="1705B7ACDFE2A225" modified="2015-09-16" version="1">MPLIQLEPHLFTSLPRHPDIQGDANTRDLREFIQATLLEAQPLLNQFPSTLKPDCKLRSSPPSKAKVKLSRGWRTLQSPQEGPNPNKEFWVCRQSDHQDSDRLPGTVSLWEFHDGLRYNHAEHEMEYTPSVTSVKQLLKWNEPRQWDLNQPITIGNMNYKHFEVELNLIVHTFHPQAVIRPRAFISWTMSATFASSYPTAQSTPNHGFINVQIPFYLTKPISPGSQYEGLYAQIMDAVPQRAVFAYYASLERVERVRPPTPPAPGPSASTDMNTPATSPERYLRWTMLTTSEAGGKIPKWVQRSWTLGGAPRAVVSDVGLFIRWTLKRREERRLEQDSQMGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </location>
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        <location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL26324.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="66" mass="7291" checksum="6013B737505E24F6" modified="2015-09-16" version="1">MPKQPKTTPVTTSPSASRPRRAQLYRYAPCYRCAGGMLLHFRPVNGPAGGGYVARGLRVYGLRVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJ25</accession>
    <name>A0A0G4PJ25_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Legume-like lectin</fullName>
        </submittedName>
    </protein>
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
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                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793150">
        <property type="protein sequence ID" value="CRL26216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJ25"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJ25"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07308">
        <property type="entry name" value="lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000095">
        <property type="entry name" value="Lectin family integral membrane protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF45">
        <property type="entry name" value="RE50040P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51328">
        <property type="entry name" value="L_LECTIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0430">Lectin</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195717" evidence="8">
        <location>
            <begin position="23"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="L-type lectin-like" evidence="9">
        <location>
            <begin position="30"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL26216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="325" mass="36355" checksum="E3349E0A72139C3D" modified="2015-09-16" version="1">MRLPSISSLLCFAGLVALPVNAYDDPNIKSIPLRTHSLSPPYLDSDFQSRWFDFGGDTVIRADKYVRLTADRPSQQGWISSRVPLTATNWQIELEFEIHGSGNLHGDGFALWLTKERATQGPVFGSTDRFEGLGIFFDTYKNNRPGVSFPYVMAMMGDGQTTYDQAHDGKANELAGCSARGLRSAPVPTKARLTYFQDKSLSLELQYKSEDTWTECFNLSAEDSNIAIPSVAYLGLSAETGELSDNHDIISLKAENLYSLNRSNNNKGKTTEDRSKGRVRPSSKPVKEKSSWSWFLFKTVLFFAVIVGGYFGWTVYRTKARSSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJC9</accession>
    <name>A0A0G4PJC9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing endonuclease subunit Sen2</fullName>
            <ecNumber evidence="4">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S018g000132</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="4"/>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJC9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJC9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000007">
        <property type="entry name" value="tRNA-splicing endonuclease subunit Sen2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016589">
        <property type="entry name" value="tRNA_splic_SEN2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00324">
        <property type="entry name" value="endA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011789">
        <property type="entry name" value="tRNA_splic_SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="8">
        <location>
            <begin position="351"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="144"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR011789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR011789-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL26439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="481" mass="54349" checksum="36899FC4D3E39DA0" modified="2015-09-16" version="1">MATPVTSMDKPVATKSGPASNGRPPRAPRPPRPNFRQIHQFPLPVNVHHVPPVIPHNPLSVISVALSYLTFLISPPRQEVYSAYFDKATSSIHVTDERSINALWQMGFFGKGSLSRSEPSWLAREKKRRGLHNEKTSEEITRLRRTERRELKLERARMEKLAIEERLKAEAAARESVASELLDEAAQSTPTDDTTNVTATTTEKFSLKKAKEARLLEARQARELAAQNAALAEQNQPETPSSSKSVRFSSVVQKKEFVSTSPSALQVPDSVVDSLDVEDFPNEEHLQLSNEEAFFLAYSLGALQIYDSPLKSGEDQSISPITTSALLQKFCHHSFQPARDASASLQPDDPFMTSYAVYHHFRSLGWVIRSGVKFGTDYLLYNRGPVFSHAEFAVIVIPSYTHPYWSETEERRNYTAEKQARSWWWMHCVSRVQAQVLKSLVVCYVEVPPPAASLEDIGALFGQYKVREFLIKRWIPNRTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJX8</accession>
    <name>A0A0G4PJX8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S018g000151</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJX8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJX8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL26458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="649" mass="71504" checksum="2D0368D134FECF83" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PK39</accession>
    <name>A0A0G4PK39_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">dual-specificity kinase</fullName>
            <ecNumber evidence="1">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S019g000204</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="1"/>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PK39"/>
    <dbReference type="STRING" id="1429867.A0A0G4PK39"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14134">
        <property type="entry name" value="PKc_CLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000612">
        <property type="entry name" value="Serine/threonine-protein kinase AFC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="230"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="111"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CRL26787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="592" mass="66072" checksum="9FF1D3EC721421C0" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PLG1</accession>
    <name>A0A0G4PLG1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger, FYVE/PHD-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S021g000124</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793154">
        <property type="protein sequence ID" value="CRL27209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PLG1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PLG1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045740">
        <property type="term" value="P:positive regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031445">
        <property type="term" value="P:regulation of heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15502">
        <property type="entry name" value="PHD_Phf1p_Phf2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047171">
        <property type="entry name" value="BAZ1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46510">
        <property type="entry name" value="BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46510:SF1">
        <property type="entry name" value="BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="130"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="191"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="268"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="369"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="444"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL27209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="511" mass="55738" checksum="C9CD238997AE5A9E" modified="2015-09-16" version="1">MRVSAAFVDLPAPDINPGRPQNVHEGNIFDHEGVSEGIPSLPSHLELVDDNIPWESWGSPALPQEEAIWATGGATETGHQNASTALASNRTRSGRRITQPAAREVEPVATKGPPVKAAAKKRKRLNRQVNIVCTGCYRGHSPSNNLIVLCDSCDAPWHQKCHKPNIGNQVIEIPEMNWFCIKCKPEQRQTAQTKPQKKALTKVKKVGRPKKQPVSESQMGGNHYSEEERRAYLSSLSHDSLVQLVVKVSNEWPSVPMFPTNMQPVTDFTPSPFATPHNHRASNPTPKKTPHSALLDWENLKPPSENPNAMDSNQRIGKAPDTTAPEATALDTDKLSAEVVSDVAPNPDPPAALGGITADHILAGISHAHASTTSPQPPTTTTPQNPSRPRRRFTSQAAPAATRARKASFDSSNSDLITDDESSYSQSRLQSPTPSMSQSSHVGSQHESDYDPEDYRAYPEAGQGFHVPSTPSDLDIMAEDKNCLTFSHSIRGSAKEARNKKLYSPLGQRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PLT9</accession>
    <name>A0A0G4PLT9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit J</fullName>
            <shortName evidence="5">eIF3j</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 30 kDa subunit homolog</fullName>
            <shortName evidence="5">eIF-3 30 kDa subunit homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">HCR1</name>
        <name evidence="7" type="ORF">PCAMFM013_S021g000066</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit J family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793154">
        <property type="protein sequence ID" value="CRL27151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PLT9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PLT9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.60:FF:000003">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.60">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03009">
        <property type="entry name" value="eIF3j"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023194">
        <property type="entry name" value="eIF3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013906">
        <property type="entry name" value="eIF3j"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08597">
        <property type="entry name" value="eIF3_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="211"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL27151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="265" mass="29557" checksum="44EE967CD71EFC3C" modified="2015-09-16" version="1">MPPSKWDEEEEESPAPPIVAAPRRRFDDEEEEDVLDSWDAAEDSEVEREKAKKAAEAEAKAKAAAAANKKTKAQRIEELREQRRREEGDGESDSEDEADRRARLRKTEQEADLAHAEDLFGSVDVKPNKGAPKAIVVSDSADPTKSVDLSAMPLFKPVTKDQFTRLTETLVPLLTPHSKKAHYSLWAQDFTRKLVKELPSAEIKKIASALTTASNEKMREERAADKGNKKSKAAKTKISLNASRDPHVDNTNYQGDDDLGDDDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PM33</accession>
    <name>A0A0G4PM33_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PCAMFM013_S022g000157</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 23">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="HG793155">
        <property type="protein sequence ID" value="CRL27477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PM33"/>
    <dbReference type="STRING" id="1429867.A0A0G4PM33"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16489">
        <property type="entry name" value="mRING-CH-C4HC2H_ZNRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051878">
        <property type="entry name" value="ZNRF_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNRF1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661:SF4">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="15" id="KW-0458">Lysosome</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="20">
        <location>
            <begin position="188"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="19">
        <location>
            <begin position="479"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="126"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="331"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CRL27477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="522" mass="56199" checksum="912D9545799DF010" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PM43</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
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                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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            <end position="77"/>
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            <end position="111"/>
        </location>
    </feature>
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            <end position="25"/>
        </location>
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            <end position="571"/>
        </location>
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            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
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            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
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            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
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        </location>
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            <begin position="451"/>
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            <end position="487"/>
        </location>
    </feature>
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        <location>
            <begin position="541"/>
            <end position="569"/>
        </location>
    </feature>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="CRL27251.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMS6</accession>
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        <submittedName>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Dupont J."/>
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                <person name="Lacoste S."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL27752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="62" mass="7255" checksum="AA437212F6B4A67D" modified="2015-09-16" version="1">MEHVLYRSVLGVFYDCKDLRWVTAFTYDVLRTRCYYEPLFSPIDGGQIAPRVFADLKCNSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNH5</accession>
    <name>A0A0G4PNH5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Mitochondrial escape protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCAMFM013_S024g000169</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Renault P."/>
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                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
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                <person name="Lacoste S."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 14">Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape. Involved in the regulation of mtDNA nucleotide structure and number. May have a dispensable role in early maturation of pre-rRNA.</text>
    </comment>
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        <subcellularLocation>
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    <dbReference type="STRING" id="1429867.A0A0G4PNH5"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="RRM_Yme2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mitochondrial escape protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018850">
        <property type="entry name" value="Mt_escape_2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
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        <property type="entry name" value="Yme2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034260">
        <property type="entry name" value="Yme2_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32198">
        <property type="entry name" value="MITOCHONDRIAL ESCAPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32198:SF2">
        <property type="entry name" value="MITOCHONDRIAL ESCAPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA12"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 14" id="KW-0496">Mitochondrion</keyword>
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    <keyword evidence="4 14" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="186"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010320"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00020222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CRL27914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="829" mass="93355" checksum="F2EB84727B97A4D4" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNQ5</accession>
    <name>A0A0G4PNQ5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S025g000077</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793158">
        <property type="protein sequence ID" value="CRL28019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PNQ5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025122">
        <property type="entry name" value="DUF4048"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13257">
        <property type="entry name" value="DUF4048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4048" evidence="3">
        <location>
            <begin position="240"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="349"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="561"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="353"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="392"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="434"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="471"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="484"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="568"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL28019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="588" mass="63384" checksum="1DA5FA91EF283189" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPM4</accession>
    <name>A0A0G4PPM4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase</fullName>
            <shortName evidence="11">HMP-P synthase</shortName>
            <shortName evidence="11">Hydroxymethylpyrimidine phosphate synthase</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S025g000164</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-(pyridoxal phosphate)-L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + L-histidyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 2 Fe(3+) + 4 H2O = L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + (2S)-2-amino-5-hydroxy-4-oxopentanoyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 3-oxopropanoate + 2 Fe(2+) + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:65756"/>
            <dbReference type="Rhea" id="RHEA-COMP:16892"/>
            <dbReference type="Rhea" id="RHEA-COMP:16893"/>
            <dbReference type="Rhea" id="RHEA-COMP:16894"/>
            <dbReference type="Rhea" id="RHEA-COMP:16895"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:33190"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:143915"/>
            <dbReference type="ChEBI" id="CHEBI:157692"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:65757"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the NMT1/THI5 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793158">
        <property type="protein sequence ID" value="CRL28106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PPM4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PPM4"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13650">
        <property type="entry name" value="PBP2_THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000187">
        <property type="entry name" value="4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027939">
        <property type="entry name" value="NMT1/THI5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31528">
        <property type="entry name" value="4-AMINO-5-HYDROXYMETHYL-2-METHYLPYRIMIDINE PHOSPHATE SYNTHASE THI11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31528:SF1">
        <property type="entry name" value="4-AMINO-5-HYDROXYMETHYL-2-METHYLPYRIMIDINE PHOSPHATE SYNTHASE THI11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SsuA/THI5-like" evidence="12">
        <location>
            <begin position="16"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL28106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="342" mass="38008" checksum="B35714F2A7E5C670" modified="2015-09-16" version="1">MSTDKITFLTNWHATPYHAPLYLAQARGYFKDEGLKVALLEPNDPSDVTEIVGSGKVDMGFKAMIHTLAAKARDFPVTSIGSLLDEPFTGVVYLKSSGITEDFRSLKGKRIGYVGEFGKIQIDELTKYYGMTADDYTAVRCGMNITKAIINGTIDAGIGLENVQMVELEEWLAVQNRPRTDVQMLRIDQLAELGCCCFCSILYIANDAFIAANPEKVSAFMRAVKRATDDVLADPAAAYAEYIDVKPIMGTDVNRKIFERSFAYFSRDLKNVQRDWTKVTNYGKRLGILKEDFVANYTNEFLSWGLDADSTDPIGDQKRMAALQQEVAADGGYKRLEVQASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PR01</accession>
    <name>A0A0G4PR01_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein PXR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">PinX1-related protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protein pxr1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S031g000007</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in rRNA-processing at A0, A1 and A2 sites and negatively regulates telomerase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PINX1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793164">
        <property type="protein sequence ID" value="CRL28839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PR01"/>
    <dbReference type="STRING" id="1429867.A0A0G4PR01"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050656">
        <property type="entry name" value="PINX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149:SF31">
        <property type="entry name" value="PROTEIN PXR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="G-patch" evidence="11">
        <location>
            <begin position="25"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="140"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL28839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="289" mass="31635" checksum="DFDDB8DC7AA6A190" modified="2015-09-16" version="1">MGLAGPRKSTKIGNDPNNTKWTRSTTGFGHRIMSSQGWTPGSLLGAKDAAHANHLTAASASHIKVTLKDDNLGLGARIGRESEPTGLDAFKGLLGRLNGKSEVELKKDERKRDDVRLARYAALKFPEVRFVSGGLLAQEKEAAIPPPTPEDATSKKSKSDKKEAAKITEDDEISSSESDAPARKSKSKSKSKSKSKSKSKSKKSRSRDETDDESSSESKKKKKSKKRKADSEQSDSSDKTSEPEVKVAATISRERRPMGRNVTRSRHIAQKKRAIMDDKSLNEIFMIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRV8</accession>
    <name>A0A0G4PRV8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S031g000026</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793164">
        <property type="protein sequence ID" value="CRL28858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PRV8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PRV8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL28858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="488" mass="54993" checksum="C1F3755F93C47A7B" modified="2015-09-16" version="1">MISTVHLAIFTIILGLVLILRTFTNKGTNLPPGPKGKFLIGNFSVTVLGKTLIIINDRELAFQVLEKNSIKHSSRPHLVFAGELAGWGKLVPSQDNTPLLRAYRRAITRVIGTRESAAKFNGLIELEARRFACRILHTPEKFLDHNRTASGAFIPTITYGYNIEPHGEDPLVRLANLAVKKFSEAAVPGAWLVDFIPSVKYVPEWMPGANFQKVAKDHVQTITRFAESPFAFTKAQMDRGKDRQCFVSTLSQTRRRRRNRQMVGGGNVWWCRRYEGFFLAMMLFPDVQRKAQAEMDELFGKPALPSATDRERLPYVNAIVKEATRWLTVVPLGIPHRTDQDDIINGYLILKNAIIVPNTWSFNNDPTIYPNPRDFEPERFLSKPGALEPGDVSFGFGRRVCPGRLIAETSIFLIIAHTLAIFDIRKPAENGEEIKSTLDSTPGLLIHLVPFNASITPRSREHEQLIVDFEKTHPFETGDSKVLADVYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PS60</accession>
    <name>A0A0G4PS60_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">O-methyltransferase, COMT, eukaryota</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S031g000104</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793164">
        <property type="protein sequence ID" value="CRL28936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PS60"/>
    <dbReference type="STRING" id="1429867.A0A0G4PS60"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF12">
        <property type="entry name" value="STERIGMATOCYSTIN 8-O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="5">
        <location>
            <begin position="84"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="184"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL28936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="402" mass="45094" checksum="A90601CF806E3B47" modified="2015-09-16" version="1">MDRATLTTRATEIADVVHSLAGDLLSQGIPEPSFEHGLPDILQSDAQDSNALAARMKLLGLLDELRDLLTDPPLLGSPELRNPSMSILALVRLKIFENFPSEGITIKDLAERVNRNENIVRRLMSHAATYHVFFQEKPDFFIHTAGSRVLTENEGMRSWMLVGLGETMPGALKGWNIQNNTDLPVFQALATMPERATIFAKAMSWHAQLPGYSPQYLLDHFPFGSGDITVVDVGGGIGHIARALADHCPTVQCIVQDPPEVILQAEQALPANLQDRIRFQPHDFFQDQPVHGADIYLLRHVLHDWSNKYARKILQALIPALKPGAKVVLNDRSIPGYGEAHYLKEREARDYDLYMLGLQNAQERTPDDWKSLFRDTDSRFNVTKISQPSKSYLSIMEVTWEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PSC1</accession>
    <name>A0A0G4PSC1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidase M20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S032g000047</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793165">
        <property type="protein sequence ID" value="CRL29011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PSC1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PSC1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05652">
        <property type="entry name" value="M20_ArgE_DapE-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050072">
        <property type="entry name" value="Peptidase_M20A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808">
        <property type="entry name" value="ACETYLORNITHINE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808:SF14">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="6">
        <location>
            <begin position="161"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL29011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="342" mass="36996" checksum="99FC06352C263ACD" modified="2015-09-16" version="1">MASAVVTLLGQLMQIPSISNEEHDIGLFLEQHLQSLGYTVERIPISPDSHRCNVYAYLGSSRKTRICLTSHMDTVPPHIPMRVTPTTIYGRGSCDDKGPLAAQIIALEELRAEDRVQPSDVSLLFVVGEEKGGPGMIAANLMNLSWEALIFGEPTEGKLAVGHKGHFVFELTSEGVPAHSGYPQRGRSAISVMTAVLAALERATYPSSDIIGPSTFHCGQITGGVGYNVLAAECTALCAIRVASDLPGIEQLVEAIVSEHENVHLNKKFMYPELYLDHDVPGMGTMPVAFGTDAPRLKGEHKKYLYGPGSILVAHGDNESIEIGELIESVQVYKRIVEHCLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PSD2</accession>
    <name>A0A0G4PSD2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sugar/inositol transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S035g000010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793168">
        <property type="protein sequence ID" value="CRL29315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PSD2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF11">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER (HXT8), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL29315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="488" mass="53019" checksum="F09AB8109237BB30" modified="2015-09-16" version="1">MVFVVALGSFTFGFNNSVIGSVLGLKSFFDYFDIDQNGGGRADSIIGATSGLFAGGGALGSLALAPLANRAGRIRAIQVTCIICIIAGIIQAASVHIIMFLIGRFLSGLGVGLMVTLVPIYQSEISPAESRGKMVGSHGTLIVTGYAFAAWTGFGCFYSPNPEFQWRFELSAQVIAPCLLLVGSLWLPESPRWLVEQNRHTEALEILSSFHSSDYQDEVGREDKAQLELSQIRAQLVADREIAQSAGRWALVTKPSYRKRLIAGCITQFLSQSTGVLVINNYQVMLYNSLGLYESLPLLLYAAYLTWAAGMNYISALIIDRVGRVRLMTIGLLGGAAAVICEAAMVAKFSGTSNKVGNGFGVAFLFLFVTFYGVCLDATTWVYCAEIFPTHTRSRGMGISIFTQFCTTLVFTQAAPMAFNTIGWRYYLVFIIIPVLGAVVMFFTFPETKGLSLEDISMVFGDEQIGMEVTPEPADRPEKLSVCDKESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PST1</accession>
    <name>A0A0G4PST1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S034g000014</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the IPI1/TEX10 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793167">
        <property type="protein sequence ID" value="CRL29216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PST1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PST1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024679">
        <property type="entry name" value="Ipi1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF2">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12333">
        <property type="entry name" value="Ipi1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein Ipi1 N-terminal" evidence="8">
        <location>
            <begin position="132"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL29216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="345" mass="37378" checksum="312378A01FD51B04" modified="2015-09-16" version="1">MGSSSKRKKDKQKDFQKPKLKVGKTKAKPDNYTDTSFKSKSIVLTQQSLHLSAPTSNATFTHNLSLLSAKSDSQRRDSLAYLTTTISSRPVNSPLPQPVSVILPSLLPLILDGTTSVRTQLLKLLRTLPSGDVEDHVAQLLPYVRAGMTHLAADIRSSAVEILSWMVEAAGESTVSCAGGWIKTLNCFLSVLGWHTEESSQWSSSRASFGKSGSQGKPMVKTLGALAMFLDAGIGKPSIGGVDSEMSGDDDESADWPFPLCQTAQHMISDSSTPFAYLNLFGKPRDEEGEMYETREDRYRVFSTRFQPAIERGIKSAREEGGELGRASSGVSKVLKEAIAYGPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PTB6</accession>
    <name>A0A0G4PTB6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="3">FBP aldolase</shortName>
            <ecNumber evidence="3">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S035g000026</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2 3">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="3"/>
    <dbReference type="EMBL" id="HG793168">
        <property type="protein sequence ID" value="CRL29331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PTB6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PTB6"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00947">
        <property type="entry name" value="TBP_aldolase_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050246">
        <property type="entry name" value="Class_II_FBP_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30304">
        <property type="entry name" value="D-TAGATOSE-1,6-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30304:SF0">
        <property type="entry name" value="D-TAGATOSE-1,6-BISPHOSPHATE ALDOLASE SUBUNIT GATY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL29331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="288" mass="31475" checksum="09C9BB92156FED1B" modified="2015-09-16" version="1">MTLQENRALRILDHASANQYGIPAMCCYNVEGILATVRAAEAKRSAAMILLFPWAIHYADGLLVHAAAEAARKATVPVTVHMDHAQTPEIIRYAADMGGFDSIMVDMSHYEKAENLSLTRELVEYCHARGIATEAEPGRIEGGEDGVADTADLEGLLTTPEESREFVDTGIDWLAPAFGNVHGEYGPRGIQLEYERLKSINEAVGREVRLVLHGADPFTEEIFKKCIDCGVSKVNINKVLNNEYVRVQAEMAGKVPLTTLLEEATNAMQKAVEGCIDRLGSGGRYPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PTV9</accession>
    <name>A0A0G4PTV9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 14">DNA replication licensing factor MCM6</fullName>
            <ecNumber evidence="3 14">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PCAMFM013_S037g000073</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 14"/>
    <dbReference type="EMBL" id="HG793170">
        <property type="protein sequence ID" value="CRL29586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PTV9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PTV9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990518">
        <property type="term" value="F:single-stranded 3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902969">
        <property type="term" value="P:mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17757">
        <property type="entry name" value="MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.870:FF:000002">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000009">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000115">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008049">
        <property type="entry name" value="MCM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041024">
        <property type="entry name" value="Mcm6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF43">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="9 13" id="KW-0238">DNA-binding</keyword>
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        <location>
            <begin position="477"/>
            <end position="685"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
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        <location>
            <begin position="797"/>
            <end position="846"/>
        </location>
    </feature>
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        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
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        <location>
            <begin position="811"/>
            <end position="824"/>
        </location>
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        </source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU368064"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL29586.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="954" mass="105221" checksum="6EF4CDDF3A8C792D" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUA2</accession>
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        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">PCAMFM013_S039g000063</name>
    </gene>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CRL29754.1"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="419" mass="50564" checksum="EDC4D0ED12B4A819" modified="2015-09-16" version="1">MPFEMPFEMPFEMPFEMPFEMPFEMPFEMPFEMPFEMPFEMPFEMPFEMPFEMPFEMPFEMPFEMPFEMPFEMPFEMPFEMPFEMPFEMPFEMPFEMPFEMPFEMPFEMPFEMPFEMPFEMPFEMPFEMPFEMPFEMPFEMPFEMPFEMPFEMPFEMPFEMPFEMPFEMPFEMPFEMPFEMPFEMPFEMPFEMPFEMPFEMPFEMPFEMPFEMPFEMPFEMPFPPSHFFQNILLLPLPILYPSYFIYHSLTFLPYIENGKRLGPSTGGKIDMGTVSTWMVFHFSIHNYWDNVKQEARLTLSYVRLTDEGIFYCICTMTPHQRTSRFQADFDQHGDIRTSRILLDPPMIVWANGLPWFPVYKAFSVLCGSWNAVSYLVGRKYRSSISEFYLGAALAPPEAVQASQEDSLTSSYFLPCIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUF1</accession>
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            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.</text>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PUMMELIG, ISOFORM A"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="158"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
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        <location>
            <begin position="84"/>
            <end position="124"/>
        </location>
    </feature>
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        <location>
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            <end position="328"/>
        </location>
    </feature>
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        <location>
            <begin position="434"/>
            <end position="465"/>
        </location>
    </feature>
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        <location>
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            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="439"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038097"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL29936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="558" mass="61698" checksum="977E2C6E1EC44138" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVA5</accession>
    <name>A0A0G4PVA5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
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        <name evidence="9" type="ORF">PCAMFM013_S044g000013</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793177">
        <property type="protein sequence ID" value="CRL30082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PVA5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
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    <sequence length="733" mass="82453" checksum="2A25198112CF606C" modified="2015-09-16" version="1"> </sequence>
</entry>
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            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="161" mass="17591" checksum="B51D3403986C62EA" modified="2015-09-16" version="1">MGISSEMRSPAAGRAKHHRGKGLASGLLRTLKQDHDDIYGVMSSHPAACLAAAKAFGKTIEKIDLNFIGKNANEVMSTSPIPYIRKAELCGIIFNADDTSGIVSGVNTHFFVDHTEPLEALAVVEIEWQWPLGKLPDGHEYLLILPAKQRRSRSRSADVSR</sequence>
</entry>
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            <dbReference type="PubMed" id="24407037"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="32" mass="3670" checksum="BEFF6935F2498A78" modified="2015-09-16" version="1">MVVQPKLETNPADAVNQKARRRRSTLFKKASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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            </authorList>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF16">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17270)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
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            <begin position="42"/>
            <end position="429"/>
        </location>
    </feature>
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    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL31082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="434" mass="46766" checksum="12EB8A3E2269BADE" modified="2015-09-16" version="1">MSTQTQTETIVLQTRASTEATPTENETFQDSRPPEPKWMYAKILSAGLSFFVAGVNDGSLGSLIPYVIRTYDIGTNMVAVLYGTTFFGWLIAALTNGKITQYLDLGPILSLGAAIQVLAQVLRVWEPPFALYAVTFFLASLGQAYNDTHANTFVSALNGAHRWLGFIHAMYMAGCLVGPFVATGVASANVDSKWYLFYLFPLGVGVANLAFVGVSFRDRMATPTVLRGDRSGRTASNSALKEIKDTLSTPGVWLLSLFFFFFLGASITAGGWMVEYLVNVRNGDVKAMGYVPAGFYGGAFLGRLILAEPTHRLGERRMIFIYSLLCVGLQLVFWLVPNIITEAVAVSLLGFFSGPFFATGISVGSKIFSPEIRSSAIAFIFVLGQIGGSVFPALTGIIAGQVGVQVLQPMLVGLLGAAGVSWLILPKDRALHQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PX60</accession>
    <name>A0A0G4PX60_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
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    <organism evidence="1 2">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL30791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="80" mass="9551" checksum="2B300631274457C0" modified="2015-09-16" version="1">MSKIQQKHYEETAMRQNCDNILRAYAMDNAGLEKQNQCFIEQINIAQQKACDLEVKNRELEYQLAKERQQHPKQPKERQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PXJ4</accession>
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        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S070g000007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL31058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="223" mass="25042" checksum="D766957353918BF7" modified="2015-09-16" version="1">MEPCQTKNTPMSPKQVLNRCPDKEPPDEETKARFATAIGSLMYLMVKTRPDIAFALGTLSRFTSQPKSHHQVALQRLLRYVKIHAIPSHYIPQWPIDWIYGMPTSGASSSLMEPTRVRLRIPTCGGSAPSWPKQNCIGPRSPTSWPTTSPLSRNPEFHKRTKHFNVKFHYQRAVLNTGEIGLQYVPTEEQAADGLTKPLGPTAFAKFCSLLGIEASETRRQQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PXK2</accession>
    <name>A0A0G4PXK2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molecular chaperone, heat shock protein, Hsp40, DnaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S077g000012</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793209">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PXK2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051938">
        <property type="entry name" value="Apopto_cytoskel_mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145:SF3">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="4">
        <location>
            <begin position="58"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL31131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="263" mass="30633" checksum="256B32AEB9A5DDC1" modified="2015-09-16" version="1">MYRKAACNAHILLSSTRQSICLNGTTSERSPGRRDSFSTKKKYRASHYSTWPSSDRPTPYQVMGIQRGHKYSRTRYYDLVKIYHPDSSTSDIAKRLPTEERLSRYRLIVDAHEILSDQQKRSAYDAYGLGWPLPSRHHGYDNIPQSPRHTYERWDDIDSEHGAVNEFLGRLLKNKKFICLMIVIATFAQACVILSSVAKTKLEMRRRDEECRDLIFRHRDRALDLRTLVAQMERLLLKRDPSGMGLGPTEEPFYREMLPFCGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PXV6</accession>
    <name>A0A0G4PXV6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Collagen triple helix repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S065g000019</name>
    </gene>
    <organism evidence="1 2">
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            <taxon>Penicillium</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793198">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR34231:SF4">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR34231">
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    </dbReference>
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    <keyword evidence="1" id="KW-0176">Collagen</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL30969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="240" mass="28463" checksum="1D96E1F9D77C4493" modified="2015-09-16" version="1">MVKMVKMVKMVKMVKMVKMVKMVKIVKIVKMVKMVKMVKMVKMVKMVKMVKMVKIVKIVKMVKMVKMVKMVKMVKMVKMVKMVKIVKIVKMVKMVKMVKMVKMVKMVKMVKMVKIVKIVKMVKMVKMVKMVKMVKMVKMVKMVKIVKIVKMVKMVKMVKMVKMVKMVKMVKMVKIVKIVKMVKMVKMVKMVKMVKMVKMVKMVKIVKIVKMVKMVKMVKMVKMVKMVKMVKMVKMVKMLM</sequence>
</entry>
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    <accession>A0A0G4PYG8</accession>
    <name>A0A0G4PYG8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
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    </gene>
    <organism evidence="1 2">
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        <lineage>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793285">
        <property type="protein sequence ID" value="CRL31377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PYG8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL31377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="93" mass="10455" checksum="BFC29533A65BF67E" modified="2015-09-16" version="1">MSPGWGLLQDLTGHTSNELQRLHKTGTERSNNSVHQVLQNLQDTICTLVEKACQAQAECEEFCSVNASFSARDVLEPVRRMYTDRQASSQSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PYM9</accession>
    <name>A0A0G4PYM9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S3Jg000055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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</entry>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="532" mass="58396" checksum="7C7F0BB068EF3169" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Dupont J."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="285"/>
        </location>
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        <location>
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        </ligand>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NT41</accession>
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            <fullName evidence="11">Quinate transporter</fullName>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Integral membrane transporter that imports quinic acid to be catabolized as a carbon source.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with creB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NT41"/>
    <dbReference type="STRING" id="1429867.A0A0G4NT41"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF34">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="21"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="14">
        <location>
            <begin position="24"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00043213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CRL17218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="535" mass="59650" checksum="5910EB2B55B8070A" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NT68</accession>
    <name>A0A0G4NT68_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Structure-specific endonuclease subunit SLX4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SLX4</name>
        <name evidence="11" type="ORF">PCAMFM013_S001g000216</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a heterodimer with SLX1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="9">Phosphorylated in response to DNA damage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SLX4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NT68"/>
    <dbReference type="STRING" id="1429867.A0A0G4NT68"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22999">
        <property type="entry name" value="SAP_SLX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03110">
        <property type="entry name" value="Endonuc_su_Slx4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027784">
        <property type="entry name" value="Slx4_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018574">
        <property type="entry name" value="Structure-sp_endonuc_su_Slx4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09494">
        <property type="entry name" value="Slx4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="295"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="466"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="620"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="738"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="518"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="539"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="560"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="677"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="778"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL17256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="886" mass="95919" checksum="659EAC0381E53E53" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NT73</accession>
    <name>A0A0G4NT73_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">BZIP transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S001g000221</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Positive regulator of amino acid starvation-induced autophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
            <location evidence="4">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SCOC family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:trans-Golgi network"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR21614:SF0">
        <property type="entry name" value="GEO08385P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21614">
        <property type="entry name" value="SHORT COILED COIL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10224">
        <property type="entry name" value="DUF2205"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
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        <location>
            <begin position="102"/>
            <end position="143"/>
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        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
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        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002743"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010880"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL17261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="18663" checksum="F35D52833431165F" modified="2015-09-16" version="1">MASDTEMTEASPVDTLPQPNDGGRMHMSSLSSSSSISDAENERRGRSERPRMASRKPSASILVPRDHPEIEIEEEEFPPDDARAMSPRRNSADLERLGKEARQTLQEQAKALQSSLQALAERIDAVKSDHDKLENENKILQDYIGGLTRNMTKSEMSRSTKARKAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NUP1</accession>
    <name>A0A0G4NUP1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">B-related factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S001g000746</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
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        <property type="entry name" value="TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Cyclin-like" evidence="12">
        <location>
            <begin position="141"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="12">
        <location>
            <begin position="241"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="339"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="429"/>
            <end position="460"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="539"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="606"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="369"/>
            <end position="382"/>
        </location>
    </feature>
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        <location>
            <begin position="620"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="727"/>
            <end position="736"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00031009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL17786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="736" mass="80246" checksum="CD92952F1315AC4D" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NUV3</accession>
    <name>A0A0G4NUV3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras guanine nucleotide exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S001g000802</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF363">
        <property type="entry name" value="PROTEIN SON OF SEVENLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="27" xmlns="https://uniprot.org/uniprot">
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                <person name="Dupont J."/>
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            <dbReference type="PubMed" id="24407037"/>
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</entry>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <authorList>
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                <person name="Dupont J."/>
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                <person name="Abraham A.L."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11843">
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    </dbReference>
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        <location>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL17934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="148" mass="16153" checksum="247F42A546F7E131" modified="2015-09-16" version="1">MSDGEEPTSPIAPAEEVEVSADAGSGQMSVLDALKGVLRVSLIHDGLARGLREAAKALDRREAHMCVLNEGCEEEAYKKLVVALCSEHKIPLIKVPDGKMLGEWVGLCTLDREGNARKVVNCSCVVVKDWGEESQERSVLLNYFQTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NVL7</accession>
    <name>A0A0G4NVL7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S001g001088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL18128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NVL7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL18128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="385" mass="45184" checksum="B048628CFE9C7E36" modified="2015-09-16" version="1">MLRTGHATCNLCGSKIHSFAATQISEIIYRDKPQDLNIFSPHNSWICGRPADLEDIHFDEIWTWSCTFRAGKLFLRARQGVTFHLSGVGEFRPAQQISLPRNENEMILWNHRSHSQQASPIPNFVSRVEYPKAFPMHERCWQLMTRILDVDVIKQNMDSFVPAMFNPKFLTHSRRWSDRILMAPEVKAVLGCTSTLPPRFHPTTQVFRSKDSWNPSRMKRGFLGTDPLNDSYIKDVIAKYTAKYTSQREKGCEPMSQHSIPTHTMFRRSQVTFKTRNVFLPTELILNIADHLKHHKDIRALLSAFPHWYPMIPESYWRSRFIEDNHLESNHFPAADALDWQHVYLHSDRLPRPSFGWRNRQHILSQLEGVKERFLQRLKQKGIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NW17</accession>
    <name>A0A0G4NW17_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidyl-prolyl cis-trans isomerase-like 1</fullName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Rotamase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S002g000161</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NW17"/>
    <dbReference type="STRING" id="1429867.A0A0G4NW17"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01927">
        <property type="entry name" value="cyclophilin_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000003">
        <property type="entry name" value="Peptidylprolyl isomerase domain and WD repeat-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000450">
        <property type="entry name" value="Peptidylprolyl isomerase domain and WD-repeat protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4 10" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="113"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="12">
        <location>
            <begin position="481"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL18291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="627" mass="69564" checksum="5A772F2B38A248CE" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NW96</accession>
    <name>A0A0G4NW96_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome biogenesis protein SLX9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S002g000195</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLX9 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NW96"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028160">
        <property type="entry name" value="Slx9-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15341">
        <property type="entry name" value="SLX9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="117"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL18325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="171" mass="19065" checksum="B4D0A9DFD8BD7B45" modified="2015-09-16" version="1">MVKAPIRKSTKTASGRGAIAKPNVFGDEFRTSKRDKRQIKHAALVSKIEKNSQKTPKRRRASKKLVANLESLADALPEAEESTDAASQVNVIKQKTLRHKPGALKRREKLEKLERDRFNKNLTEMSNITSAPAANTGEASTESNPTAGRWSALRNFISQTMEQQPVFKPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWK8</accession>
    <name>A0A0G4NWK8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S002g000358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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            <begin position="12"/>
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        </location>
    </feature>
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    </feature>
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        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="382" mass="42937" checksum="BB92A8D3ECB0D71B" modified="2015-09-16" version="1">MQYSVDSARVPFLILTILAAILLEGILMVDGGLFAMLKPVWTQTLADGKYLHQVYTGLPIIDQILAISVCFWDPVATNLPILRLQSIMLCAPLQTFAVWATIESMRRGEKHTLLRVVPIYVFLWQYLGTAIFFPFYLFVELSQHFGSSNRTDPSIPYYDAKALLPATLLAMVLPYRNVYFPPSGTTDAQHHMFIAFYQLGPFATYTLTAGIAKYISSGKEEESRLPSNSDAPWIKAIYAVYGIFSALAHIGVILRVAFSSDPAFSLSRLFFPALQNLWNPEAVARRYVEEHLFFLQWDFILVVLGCSIYASRVAQGMYSSRESGSSTFFGVGGILIASLASMIFSPGAMITAILYVREDFIREEYATKQRREKQTEVLQDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
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                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="18"/>
        </location>
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    <feature type="chain" id="PRO_5005194837" evidence="2">
        <location>
            <begin position="19"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL18446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="341" mass="38166" checksum="46C594D5957D5D97" modified="2015-09-16" version="1">MILLTTCILAITSGTTFARAGPLSKPAKFDWSSTKALIAFGDSYTYVQGTLGHQNFSFIGDQFNLAYDAETLLSNKIVQNQTATAEGGPNWVEYLTNCGVHQGLTSPQNCKKQLWDFAFAGADISTEYTPLHHNFTVSLVDQINQFKQYGHPALLHNLADFKQDKTLIALWIGINDINDSAKYAVDFPSFYKSLTDTLFASVEILYGLGYRNYLFMNLPPLDRTPGNQVKSEPSPNATQVGWYNAALADHAATFAEKHKEARVMLFDAHARLADMLDEPWEYGIVNTTDFCAGYDQPDIAVEYEKYGCPTPLEKYFWFNSGHMTSHVHEVLAGEVERWLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWX2</accession>
    <name>A0A0G4NWX2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S002g000426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR39610">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
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            <end position="233"/>
        </location>
    </feature>
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            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
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            <end position="119"/>
        </location>
    </feature>
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            <end position="139"/>
        </location>
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        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="174"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL18556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="288" mass="31232" checksum="5E40FA012E30E0E8" modified="2015-09-16" version="1">MAPDLSAVSNSTMARPRAVTSAPAMASQSPTPRQPVHGPHISTALPPPGSPPHGTGDYGITSTAQEQGPLRHPQPLTPSDLHLVLEKEQEAMVNRLTRELSILRQQTASVASTASSTSTFNEVDRAQASPTLSSSIPSHSARRNRSNSSLSSHASANQAPQSASVTGIAPSRDIPYRQTDHSRTVRSREPSLTSRRPSIGSLSSFSHNNSSVYPHRNSVSQTHLGHSPGGSLSRFEEATHHRLEVEYMKRENEQLRRRVRDLEQTLKRQKEDSASEASATPSERIIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-11-27" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXH0</accession>
    <name>A0A0G4NXH0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phytanoyl-CoA dioxygenase</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">PCAMFM013_S002g000504</name>
    </gene>
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            <taxon>Pezizomycotina</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4NXH0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048244">
        <property type="term" value="F:phytanoyl-CoA dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001561">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047128">
        <property type="entry name" value="PhyH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21308">
        <property type="entry name" value="PHYTANOYL-COA ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21308:SF8">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G09620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL18634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="396" mass="43586" checksum="61E64023DD54DC58" modified="2015-09-16" version="1">MNGPGVSSRLYSPSTPQLSQFKDICSQTTNPATYPLACEIQSNIPIYDLAALESTGLTSDLINRLQDEWHHVLHTGPGVYVLRSMYAPTKYETTLNTTNTAFNAIIAREAAQSENKKGDHFAVGGTNDRIWNSFSKHALQDPSSFIDYYSNPWLAAVAEAWLGPAYRVTAQVNAVHPGGAAQEAHRDYHLGFQEEVACKRYPAATQLTSQFLTLQGAVAHTDMPVSSGPTRFLPYSQTYKPGYLAWRKPEFRAFFQEKYVALPLSFGDGLFFNPALFHAAGANQMDPQNGGFRRVANLLQISSAFGKPMETVDSVPLVDAIWDLLVERFRVAGGVLAGQELDPETHSLQQREIRAFVQAVAEGYPFPTNLDQRPPALSGMAPESEQDIVVRGLEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXJ3</accession>
    <name>A0A0G4NXJ3_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein YTM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">YTM1</name>
        <name evidence="9" type="ORF">PCAMFM013_S002g000539</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR12/YTM1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CRL18669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000593">
        <property type="entry name" value="Ribosome biogenesis protein ytm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03029">
        <property type="entry name" value="WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028599">
        <property type="entry name" value="WDR12/Ytm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF11">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="8">
        <location>
            <begin position="18"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="137"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="171"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="220"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="294"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="381"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL18669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="489" mass="52262" checksum="50A7F3DB3D09D1F3" modified="2015-09-16" version="1">MSEDLVTSAAAESALRQVRVQLISQQEDIALPESTGPILVPTGLRRYALSTLVNNLLSSEKPIPFEFLINGTFLRTSIDEYLVDNGISAETTLEIEYVRALIPPLHIASFQHDDWVSATDVLSTTSPAASWASGATFTKGQERILSGSYDGLLRIWNMSSETVATSPAAADGGHTASIRAAKFVSPNQIASAGLDRTVRLWKYTEGEGGFTGKISPQLELYGHKAGIESLAVHAKSNRLLTGSADNTVGFWSTKKADAPAAPENLLPSSNARNTKRRKLNTSVTTPQRGPLTLLSAHTAPVSAAIFDGKDATVGYSASWDHSLRTWDLVTGSLVDTRTTSHSLLSLEHLPELSLLAAGTAARHITLIDPRASATTVAAMTLRGHTNAVVSLARDPHSTYGLISGSHDGTCRIWDIRSTKTDKEGVVGESVYSITRKSLEEEGKSDSKRVGGEGVKVFSVCWDKTVGIVSAGEDKRIQINRGEGVLSSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXR8</accession>
    <name>A0A0G4NXR8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Barwin-related endoglucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S002g000725</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NXR8"/>
    <dbReference type="STRING" id="1429867.A0A0G4NXR8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005194864" evidence="3">
        <location>
            <begin position="22"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL18855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="274" mass="27916" checksum="E030E517FE92B456" modified="2015-09-16" version="1">MAPITKTLALAGAFFALTGYSAPVAKRAVVWTTVTDVVWTTVDVTTTVYPQAAHTATVVPVVANAVPTTTAAPVVQAPTKEVEEAAPTTTSTTTAAPVPTVEAPAKQVEQAAPTTTSSTTTAAPAPTVEAETSTTPAPVVQAETSTSSAAPAATRSANTETTISTRTGVCSEGSPCDGEITFYDTATTSTNPSSCGTTNDGTVENVLALPHGIMTDSDCGKTVTITYKGQTATGIVVDKCMGCDNGSVDLSRHLFGELAPMDKGRVDGAKWYIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NY46</accession>
    <name>A0A0G4NY46_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SNF2-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S002g000855</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NY46"/>
    <dbReference type="STRING" id="1429867.A0A0G4NY46"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF52">
        <property type="entry name" value="SINGLE-STRANDED DNA-DEPENDENT ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        </location>
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        </location>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
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        <name evidence="10" type="ORF">PCAMFM013_S002g001067</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL19197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NYN8"/>
    <dbReference type="STRING" id="1429867.A0A0G4NYN8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050562">
        <property type="entry name" value="FAD_mOase_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356:SF2">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE ASQG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD-binding" evidence="9">
        <location>
            <begin position="7"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL19197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="472" mass="52901" checksum="754B2F41B46236DA" modified="2015-09-16" version="1">MSKSAFQVIIVGGSIGGLTFAHCLQRAGIDHVVLEKASNPAPQIGASIGISPNGARVLDQLQLYELVEEHIEPLTVATIRYPDGYSFKGSFPKVISERFGYPIAFLDRQKMLEILYESYPDHRNIRLGEKVTTIESCGNTAIVRTSTGSVYRGHLIVGADGVHSKVRQEIWNALEKTSPGVANERSNLTVEFRCMFGISSAIKELIPGEQVNALFDGLTIITIHGKNGRVYWFVVQKLDKTYTYPDCPRYMASDIEIAAEELRSTVFFKDLNFGHLWETRETVSMTVLEENTFETWYHDRLVLLGDSAHKMTPNIGQGANMAIEDAAALANLLQSSRKGMSTWPPTNGQVQILLHQYRSIRHGRVNSVYKSSRFLVRLHARDGLLKTLFGRYYVPYAGDLPAYIGSKSIADGVLCDFLPLPRRSGGGWERYRTKHSPLRWAPQATLYVLVFAILYTYMDWRRVLGLGSVESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZM4</accession>
    <name>A0A0G4NZM4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glucose-methanol-choline oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S003g000317</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZM4"/>
    <dbReference type="STRING" id="1429867.A0A0G4NZM4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="9">
        <location>
            <begin position="10"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="10">
        <location>
            <begin position="430"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL19526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="593" mass="65656" checksum="83AEC78DDDB93FAF" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZU4</accession>
    <name>A0A0G4NZU4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Helix-turn-helix, Psq</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S003g000325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZU4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL19534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="70" mass="7948" checksum="56F9913D7B21E093" modified="2015-09-16" version="1">MPPIRSQSSTNSTEQEGRLLLAIQAFKNRDINSISLAARTFNVLCSTLRDRLNGHTERSTIRQLYALSVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZW0</accession>
    <name>A0A0G4NZW0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kynurenine formamidase</fullName>
            <shortName evidence="3">KFA</shortName>
            <shortName evidence="3">KFase</shortName>
            <ecNumber evidence="3">3.5.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Arylformamidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">N-formylkynurenine formamidase</fullName>
            <shortName evidence="3">FKF</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S003g000396</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>N-formyl-L-kynurenine + H2O = L-kynurenine + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13009"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
            <dbReference type="EC" id="3.5.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="3">The main chain amide nitrogen atoms of the second glycine and its adjacent residue in the HGGXW motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the kynurenine formamidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.9" evidence="3"/>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZW0"/>
    <dbReference type="ESTHER" id="penca-a0a0g4nzw0">
        <property type="family name" value="Kynurenine-formamidase"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00333">
        <property type="reaction ID" value="UER00454"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03014">
        <property type="entry name" value="KFase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049492">
        <property type="entry name" value="BD-FAE-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027519">
        <property type="entry name" value="KFase_ver/fungi-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF33">
        <property type="entry name" value="KYNURENINE FORMAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20434">
        <property type="entry name" value="BD-FAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0823">Tryptophan catabolism</keyword>
    <feature type="domain" description="BD-FAE-like" evidence="5">
        <location>
            <begin position="48"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HGGXW" evidence="3">
        <location>
            <begin position="53"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL19605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="317" mass="34492" checksum="9C85D0C641ACD6F8" modified="2015-09-16" version="1">MSHFPINQATPQGTMSDHTNTETVVYGQVHNLQSIAVTTLAPRKDGYWVIYIHGGAWRDPAVTSASFDATQSILREKGLPIAGFASISYRLSAHPNHPQDPNTTDPKDFQDAKHPEHIADVEAALAFLQNTYKFGARYILVGHSCGATLAFQAVMGAVSGHREQATLTAQPTAIVGVAGIYDLRRLRDTHVEISAYQEFIEGAFGADEMLWDGISPARVAGSRGVEGGWKSGRLAVLAYSKHDGLVDGSQVEAMKEALGNWEKTGAQIPAQEDSTPDRRLRVLSISGIHDEAWENGDQLARAVTFAFEQLQEMRLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZW3</accession>
    <name>A0A0G4NZW3_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxidase FUB9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Fusaric acid biosynthesis protein 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S003g000403</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZW3"/>
    <dbReference type="STRING" id="1429867.A0A0G4NZW3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000056">
        <property type="entry name" value="hydroxyacid oxidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF149">
        <property type="entry name" value="2-HYDROXYACID OXIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="8">
        <location>
            <begin position="7"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="86"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="290"/>
            <end position="294"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="313"/>
            <end position="314"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00073420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00083297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL19612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="371" mass="41433" checksum="35293B7C378FD66D" modified="2015-09-16" version="1">MANRGKTHNEEVYCIKDLERLGSIKMQKAYREYYNEGAMDLITLRENESAYDRYMIRPRVLRDLSKLDTSTSIVGCKVKFPFGFSPTAMQTLAHPDGEEGTSKACAKNNTLMGLSNYSTKELEKVIAHSMGNPYVMQMSLLKNKKAMIQMIKRAEAAGFKALFLTLDVPYLGRRLNEYRNKFAVPEGMEYPNLFPGVDVTNLEDGDDSMAYDSSIEWPQIMPFFRQHTKMQIWGKGIYTSGDAELAIKYGFDGIVISNHGGRQLDSVPSTLDVLREIVPVAKGKFPIAVDGGIRRGTDIFKALALGADFCLAGRPAIWGLAYNGEEGVDLALNLLYDEFKTCMALAGCRNVSEIQKELVSLLQPDGRLLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P055</accession>
    <name>A0A0G4P055_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S003g000469</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P055"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL19678.1"/>
        </source>
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</entry>
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        </location>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P4A1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL21160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="65" mass="7240" checksum="280BA16DDA7BBA50" modified="2015-09-16" version="1">MSQARNGSPTKWIGDCSWYGAHRNRNRRHKKERRNGAAKHNYLGSSRASISWSPEASAGSVILSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5E4</accession>
    <name>A0A0G4P5E4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar calcium ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S006g000068</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P5E4"/>
    <dbReference type="STRING" id="1429867.A0A0G4P5E4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF22">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 10" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="12">
        <location>
            <begin position="75"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="12">
        <location>
            <begin position="264"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL21528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="409" mass="44428" checksum="214A9B3DA237F9DB" modified="2015-09-16" version="1">MSRRGTQPEPCGPEPSRHQRHQIQDADIDPWTQIQRFFKMPSQTGLKELNINHGWPVMVLLPLAGLAKIFHWNPIIVLVVNIVAIIFLSEAISISSDELAEHLGELQGALLSATFGNTVELTAGILALVHGEISFAQSVMVGSILSDILLVFGCCLITASYNKEVLEFNSALAKTLSSLMMITSVTMLLPTALYSTFPVSEIDDRVLSFSRGTSLVLLALYGGYLYFYLGTHKHLFLSNESETSDDGIQGDPSPPANRASLASSIIRLITAVAATVFCTELLLESIGDMTQTLGVSEVFIAIVFIPIASNSTEGVTVITASRTGDTDSAIRVIIDSLLQIGLFVIPFLVIIGWGIAEPMTLFFDSFQTVAMFLAILVVNHLLRDGQYAYIHGAMLLALYSSLVVAFYAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6K8</accession>
    <name>A0A0G4P6K8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AMP-dependent synthetase/ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S006g000502</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4P6K8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000003">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000014">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003417">
        <property type="entry name" value="PRK04813.1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="767"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="1856"/>
            <end position="1932"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="2952"/>
            <end position="3032"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL21962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="3452" mass="379208" checksum="CBA2D71DC9AE7806" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6U6</accession>
    <name>A0A0G4P6U6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PCAMFM013_S007g000008</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 14"/>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4P6U6"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23284">
        <property type="entry name" value="beta-trefoil_MIR_PMT2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000012">
        <property type="entry name" value="Protein O-mannosyl-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF46">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="228"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="602"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="644"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="670"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="700"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="336"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="402"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="466"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CRL22027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="744" mass="84837" checksum="61734E5F4E410717" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7B2</accession>
    <name>A0A0G4P7B2_PENC3</name>
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        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S007g000187</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22206.1"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P7B2"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="3"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL22206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="646" mass="73362" checksum="A7A39857799762FC" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7M7</accession>
    <name>A0A0G4P7M7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AMP-dependent synthetase/ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S007g000291</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P7M7"/>
    <dbReference type="STRING" id="1429867.A0A0G4P7M7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF8">
        <property type="entry name" value="ACYL-COA SYNTHETASE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="31"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="452"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL22310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="564" mass="62323" checksum="3CE3E2139FC01F69" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P818</accession>
    <name>A0A0G4P818_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S007g000459</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P818"/>
    <dbReference type="STRING" id="1429867.A0A0G4P818"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="19"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL22478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="328" mass="35793" checksum="4FC9944D8352E1DB" modified="2015-09-16" version="1">MTDAGTIHSSQPSLSKHSACDRCRTQKLGCMRVDGHPTDACLRCVRSQVECVTSSSRRPSRPTKATTAASMSSAGGSPRHNDYASFGPLDLDLDLDAHDKFDFATMDVPYEIPSSLWGSTDITNLYPDDYFPDSGIGGDFSPSIPALEFSPSADNAGPMRKYRMQLAHIHRTLYKQLFRLQSSHWDLTKVLSVAYVHHIQSSESCTSRASSATPSCPSSNPLEIFATIAAEFMDILSALVPPDLDPHGHCLSHPNPHLSSPDLLLLSWYLLLIYIYDYILAQLLAQVTNNLAALDTALQSAPVLSLGGLPVPPARHLPAYLLLVLFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P8N2</accession>
    <name>A0A0G4P8N2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S008g000094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P8N2"/>
    <dbReference type="STRING" id="1429867.A0A0G4P8N2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL22665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="264" mass="29703" checksum="D7354E51DD56B334" modified="2015-09-16" version="1">MSFGFSIGDIVLCSQITYRLFTAATIGRKNAPRDLRELEDVLFGLNCSLSQLQKASLVISSRNFNTLDHDATDVSQQLGFMVRSCLQTLGHLESATDKYRATVTTPSLVLHDEHKLKFLHSQQFTTQVKTQWRRIMWDLRGESLSQYRRKLESHLGAINLLLNTLIWSATNRIEQDGMRQGRRIEELLHQASRFNNALFYRIPKTSCAAPNSSFELSRGSSLSVSTILESVPSRPKPRLDQDSAGVYFKGSQQGHAGLSNGIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P8Y6</accession>
    <name>A0A0G4P8Y6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 6">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="1 6">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S008g000191</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="1 6"/>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P8Y6"/>
    <dbReference type="STRING" id="1429867.A0A0G4P8Y6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16207">
        <property type="entry name" value="EFh_ScPlc1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13360">
        <property type="entry name" value="PH_PLC_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08598">
        <property type="entry name" value="PI-PLC1c_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000396">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000201">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
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        </source>
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        </source>
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    <sequence length="1156" mass="128997" checksum="12F18A72457D4C53" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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</entry>
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        <submittedName>
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                <person name="Dupont J."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        </location>
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        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL22942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="71" mass="7774" checksum="22E9382675B85F72" modified="2015-09-16" version="1">MFKSQQSQHATIRHAQAKSEQLPGGGDQPIPLQALVQFWCSINLGVSIYPNNSSGYFIPHTSDSANHIPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P9K5</accession>
    <name>A0A0G4P9K5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin, RmlC-type</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PCAMFM013_S008g000425</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="108"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL22996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
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</entry>
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    <accession>A0A0G4P9R6</accession>
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            <taxon>Penicillium</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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            <dbReference type="EMBL" id="CRL23061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="56" mass="6120" checksum="4495AEDD40F62A29" modified="2015-09-16" version="1">MIGNKPTNFLWIKATTSDERGGSKGKESPGRFDLSIASNSGYHYKTTLKADDQIEG</sequence>
</entry>
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    <accession>A0A0G4P9Y4</accession>
    <name>A0A0G4P9Y4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
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            <taxon>Penicillium</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Lacoste S."/>
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            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="CRL23115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="37" mass="4076" checksum="6E27E2998F93D863" modified="2015-09-16" version="1">MLAIWLTQLLTDIGVPGFLQKPICIYTDNNGAIAFSH</sequence>
</entry>
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    <accession>A0A0G4PAZ1</accession>
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    </organism>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
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                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793142">
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="221"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL23481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="273" mass="30471" checksum="5CD170F495B82547" modified="2015-09-16" version="1">MGQTLADKNQAYWNRASHLVFKDKWIHDLQNQVFEFLTGNVDWIGVQLPAGDNERQTKLMDYACGNGIVSRSLHHLFSKCIGIDLSDGMLDEYRATAAELGLDNSRMSAVQGNLLAPTVTPTTPPLSKEELDGFDLVAICMALHHVEDIVLATKRLAERLRPGGVLLIIDWAARDLSNEPEQQASVQTTPSSSEDHHNRHHNHHHHHMHDGIDPKHPAAHTISHNNFSRDQIFSLFEQAGCGESQFMLADRLSPVPGAQSGQMQLFWARATKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCB7</accession>
    <name>A0A0G4PCB7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cation/H+ exchanger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S010g000391</name>
    </gene>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1429867.A0A0G4PCB7"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43562">
        <property type="entry name" value="NAPA-TYPE SODIUM/HYDROGEN ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43562:SF3">
        <property type="entry name" value="SODIUM ION_PROTON EXCHANGER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="532"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="12">
        <location>
            <begin position="44"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="296"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="428"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="430"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL23953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="578" mass="61631" checksum="800BF1987D88154B" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCP7</accession>
    <name>A0A0G4PCP7_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA replication complex GINS protein PSF3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S011g000066</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GINS3/PSF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PCP7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PCP7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11713">
        <property type="entry name" value="GINS_A_psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21693">
        <property type="entry name" value="GINS_B_Psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010492">
        <property type="entry name" value="GINS_Psf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038437">
        <property type="entry name" value="GINS_Psf3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055221">
        <property type="entry name" value="PSF3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22466">
        <property type="entry name" value="PSF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF3 N-terminal" evidence="8">
        <location>
            <begin position="4"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="GINS subunit" evidence="7">
        <location>
            <begin position="74"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL24072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="193" mass="21457" checksum="613671C340FF6967" modified="2015-09-16" version="1">MSYYDIDSILTDAQKLPCTFELEVPGLGILEGNAGEDIKAGTRIDLPLWLGEMLSIGARLGTSRLVTLDMPEALSERVMNALKADPRTLDLRALAPHFYNLSERILELFEEEEMVDVLGDAFKKRAAEIADHAHNSRGAVGGGVDFLRGLDETERQLFRAAHDRAKDMRIWSGEAKREVQILRSTHGDGHVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PD73</accession>
    <name>A0A0G4PD73_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S011g000193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PD73"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL24199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="75" mass="8648" checksum="E5DD215F64CB3078" modified="2015-09-16" version="1">MSALVLPTVAIGPPPLPPPKQAAYKIGQEREDLMQYRLPPKPKRVRYKHPKFGKPARGEDLAKAIWRYLRRKDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PD88</accession>
    <name>A0A0G4PD88_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="7">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S011g000208</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Vacuole membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="7"/>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PD88"/>
    <dbReference type="STRING" id="1429867.A0A0G4PD88"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039756">
        <property type="entry name" value="Lsb6/PI4K2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="9">
        <location>
            <begin position="170"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="312"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="417"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="608"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="663"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL24214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="770" mass="86908" checksum="DAC028725762ACA3" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDU3</accession>
    <name>A0A0G4PDU3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S012g000076</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PDU3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PDU3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF562">
        <property type="entry name" value="ALDEHYDE REDUCTASE II (AFU_ORTHOLOGUE AFUA_1G11360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="15"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL24467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="263" mass="28516" checksum="72493503405E69C1" modified="2015-09-16" version="1">MPSQDPYALKVGERILVTGANGFIGSHVVDVLLSLGYIVRGTVRSEKPWLNELFESKYGAGKFETVNLPTLDDKDALAAVLDSVSGIVHVASDTSFSPDPNIINYVVAATEAVLEAAAQVPSIKRVVLTSSSVAAVARYPGEGKIELTQDTWNETAIKAAWDKNTPEEAKGFLVYVASKAEGERAAYNWVKKNNPSFTFNSVLPDFTMGEILHKNIGSTGALTLQLLEGNNMVIDAVVSPTRQHSFIPYYLSAEQEEEQNVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDV6</accession>
    <name>A0A0G4PDV6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S012g000122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PDV6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PDV6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14383:SF5">
        <property type="entry name" value="RUN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14383">
        <property type="entry name" value="SWAP-70 RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL24513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="562" mass="64092" checksum="5339F7CD23DA3B67" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDW5</accession>
    <name>A0A0G4PDW5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S012g000134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PDW5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PDW5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL24525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="268" mass="30586" checksum="178930D3156E19CD" modified="2015-09-16" version="1">MKMADNANTTSAPVASPTTDPATVPTTVPLYGPGAPNDRNWDAVAKILDEAPDQGYHLPDPKTITLFPITPPLSHPDDYDAWEAMVVNQLRPLRLRNLIDDKILRPYRNAPNAERWVTLSERVYSWLSYGLDPAVNREINLRSGNIRWADKFMCQCKRYFKGEGHIAIAMAIGKFFSTRRSEFNTIEEFITGIQTRFMTARDLNGHVVPYHMMVIITLELSKIPEWKSFINMKNNELRRNPDPGSKLAIDDVRAYCREIIEKPLGRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDY2</accession>
    <name>A0A0G4PDY2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S012g000115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PDY2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PDY2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049500">
        <property type="entry name" value="Peptidase_M50B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979">
        <property type="entry name" value="OS02G0221600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979:SF2">
        <property type="entry name" value="PEPTIDASE M50B-LIKE-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13398">
        <property type="entry name" value="Peptidase_M50B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL24506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="267" mass="28851" checksum="38A8FE11BC1904A1" modified="2015-09-16" version="1">MPALYAALAQSAVETAPHQLARRGLSVNHTQGVTLGVMAAYVVVIALLWNLPYVRWVLWPFKMLVIAFHEFGHAITACCTGGKVKSISLDPHEGGVTVMQGGMSAITLPAGYLGSSIIGALLIFAGFNIVASKVASIILGVCFLLTLWWARRDWLTIVTVLLAVGLLVACWFIVHGEALRWVVLFIGVMSALYSVWDICDDLILRKVNSSDASVFAKRYGGSSQCWGVIWSLISLAFMAIGIVGGIAAFPQSFSQQETDSQNFISTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PE74</accession>
    <name>A0A0G4PE74_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S012g000250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PE74"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF17">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY FAMILY (AFU_ORTHOLOGUE AFUA_8G05690)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL24640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="208" mass="23368" checksum="D4201F9B3D6D6203" modified="2015-09-16" version="1">MSLEIHPASPTDAPGLTQVFYASFRSDLDKTMFPKTPDVTEWWEKYLSDVITGSIAGETNDILLKVTEGSESGGIVAFAKWKRPVPAADRDQPQENIVWPASSDKELCDRFFHGMEARHEKWMGDRPHYYLDMLGVHPSQQGKGLGSKLLKWGLARADAEGVEVYLSASPAGRPLYLKYGFREVDTFEPYPDYVQVAMIRSPNGQQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PEL4</accession>
    <name>A0A0G4PEL4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acetyl-CoA hydrolase</fullName>
            <ecNumber evidence="4">3.1.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetyl-CoA deacylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S012g000319</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O = acetate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20289"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="3.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyl-CoA hydrolase/transferase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.1" evidence="4"/>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PEL4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PEL4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008775">
        <property type="term" value="F:acetate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003986">
        <property type="term" value="F:acetyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.10:FF:000003">
        <property type="entry name" value="Acetyl-coA hydrolase Ach1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acetyl-CoA hydrolase Ach1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="4-hydroxybutyrate coenzyme like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.20">
        <property type="entry name" value="Acetyl-CoA hydrolase/transferase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026888">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038460">
        <property type="entry name" value="AcetylCoA_hyd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046433">
        <property type="entry name" value="ActCoA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003702">
        <property type="entry name" value="ActCoA_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43609">
        <property type="entry name" value="ACETYL-COA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43609:SF1">
        <property type="entry name" value="ACETYL-COA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13336">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02550">
        <property type="entry name" value="AcetylCoA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Acetyl-CoA hydrolase/transferase N-terminal" evidence="9">
        <location>
            <begin position="13"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Acetyl-CoA hydrolase/transferase C-terminal" evidence="10">
        <location>
            <begin position="333"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL24709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="525" mass="57989" checksum="CD5C5A86855AC4D8" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PFE9</accession>
    <name>A0A0G4PFE9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S013g000270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL25027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4PFE9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="64"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="526"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="559"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="592"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="757"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="796"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="896"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1174"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1525"/>
            <end position="1561"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1873"/>
            <end position="1907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL25027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="2031" mass="224592" checksum="0D12482C788C58BF" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PG12</accession>
    <name>A0A0G4PG12_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S014g000138</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PG12"/>
    <dbReference type="STRING" id="1429867.A0A0G4PG12"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL25242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="487" mass="54909" checksum="364019D56ECECCB5" modified="2015-09-16" version="1">MVSRAELYTMSSSTHCETSQGLGWLGPRRVGKHTKKLSSKSDIVRVTPNELHFGSPGAFHDIYHSSKRWDKDTGLYRTPGVASGSFTFLKYAQAKERREVILPIFSKKAINNLEHLVWRNANRLASSIAKTNASKSSIDLLYAFRSYTLDTIMCFTFGNCINALDAPAFSDPLILAMDASLRMLPFMKNFPMIRDLIFAVPPALVMRLIPNAQKLAPRLYQVRDLVQQQLQVVLNCPSKLDNVPHETLFHRMLDPECYRSKEVLNMTELHDEGFTLIFAGANTVADTLLMGHWHAMQNQTLLTQLRSELLTIWPDVEKQPSLTDLETLPLLTATIKESLRFIPSGVSLTRVVPPGGAMISGKHIPGGTVVGMAILHVHQSAEVWGKDALVFRPERWLESAEQANSRNGKSELDHWLVPFSRGPRMCFGMNLAWAELYIAFATMIRHFDLTIDGTTEEDMQWRECIAAYYPNRHLHAWCRPVGSGNMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGV0</accession>
    <name>A0A0G4PGV0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">beta-glucosidase</fullName>
            <ecNumber evidence="12">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S015g000152</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="12"/>
    <dbReference type="EMBL" id="HG793148">
        <property type="protein sequence ID" value="CRL25566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PGV0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PGV0"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000006">
        <property type="entry name" value="Beta-glucosidase H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000495">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000119">
        <property type="entry name" value="Probable beta-glucosidase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF27">
        <property type="entry name" value="BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 12 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="PA14" evidence="13">
        <location>
            <begin position="395"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CRL25566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="840" mass="92242" checksum="9F377C2365FF3968" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PH33</accession>
    <name>A0A0G4PH33_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S015g000242</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <authorList>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <dbReference type="EMBL" id="CRL25863.1"/>
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        <source>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PI58</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PIC3</accession>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
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    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S018g000022</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>butanoyl-CoA + hydrogencarbonate + ATP = (2S)-ethylmalonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:59520"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:60909"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:59521"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23720"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57327"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:23721"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The holoenzyme is a dodecamer composed of 6 PCCA/alpha subunits and 6 PCCB/beta subunits.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.3" evidence="2"/>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJ22"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJ22"/>
    <dbReference type="UniPathway" id="UPA00363">
        <property type="reaction ID" value="UER00861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051047">
        <property type="entry name" value="AccD/PCCB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43842">
        <property type="entry name" value="PROPIONYL-COA CARBOXYLASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43842:SF2">
        <property type="entry name" value="PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="9">
        <location>
            <begin position="53"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="10">
        <location>
            <begin position="324"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL26329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="583" mass="63260" checksum="E1B8F536E170CB1D" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJY4</accession>
    <name>A0A0G4PJY4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine phosphatase superfamily, clade-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S019g000157</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJY4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJY4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF110">
        <property type="entry name" value="2-PHOSPHOXYLOSE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL26740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="461" mass="50610" checksum="77FAB1F370EC113C" modified="2015-09-16" version="1">MVQMASSSKDLSEWNGFQWRRKMESFGSNDQSVIAKAPGGPVEAMCLHGELTDKGRETTYALGQRLRHLYVDQLGFMPQIKSDSEDMYLRATPIPRALESLQEAFWGMYPASARTLDFPPPVIVARQVNEETLFPNEGNCKRFRQLARLFADRAAARWNDSEQMAYLNSLWSKHMPEESPKVAVDAHPRLSGIMDTINATDAHGPGTKLPSEFYDKKGRAVVDRIAVEEWFAGYGESSEYRKLGIGALMGDVVDRMVSTAVEGGWRSETAASGSGNPETGKAIKFAMSGCHDTTLAAILSSVGGFQNQSWPPFTSSIAVELFSQAPRSDSDAGVMLEEFSNPPVAPKKPGVLSQLFGKSAQKQPTTSDTARAPLESLPEGARESLQKHYVRIRYNDQPVLIPGCAAKPENHLPGDETFCTLDAFKEIVDKFTPKDWQIECTANLGAGLHGPDDREKAPAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PK40</accession>
    <name>A0A0G4PK40_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S019g000141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PK40"/>
    <dbReference type="STRING" id="1429867.A0A0G4PK40"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF58">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL26724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="257" mass="29616" checksum="E772EF0E6B50C866" modified="2015-09-16" version="1">MGRIISASDLTDSNRLVADNMINVFRVDDKTVAKLCDPNRLAEAEALKFIRSKTSLPVPEVYNAYVDETIDRGVIVMEYIEEEVLRDVIQNMDDMRRQKIILELQRFMSELRSIEGDFIGSIDGSACEDPVFCAEQGGFGPYKTENEFNEGLIRAMTINEENSWVGHVSKLIRAMPSHTTVLTHADFSPRNIIIRGERVVGILDWEMAGFYPEYWEYIKAMYHPDWQSRWVQDGIVDTVLKPFYLEHAIMLHMQEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKA3</accession>
    <name>A0A0G4PKA3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NOT2/NOT3/NOT5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S019g000037</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKA3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PKA3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1020:FF:000007">
        <property type="entry name" value="Putative not2 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="5">
        <location>
            <begin position="341"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="51"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="235"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="51"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="259"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL26621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="486" mass="52511" checksum="0F4BE1451E8384D3" modified="2015-09-16" version="1">MNRPEPGPQPLRGMSGFPTQQQAQARTASLASARLSNGKLGAGANWSFNLPVSGTSGLPGTQQRTMGTMGSFAQSLGGSQSAAPLDLSEFPSLSGASQQSQSQTPGQLMWANASQRAAQQTPVQRQQLPQPSQTPSRSSQPQGLPTPQQSQPPHDDMFPSGSQFANRLDDFRNGGQGISSQLGAGGQPQTGNIEEFPPLGRNAAAELPLGRTGSLMQGAGFGGYGAGLGAPRSPVSQVPNGILGQEKDDLNNGVLPGQRNFSDPQQLQQRQPENNDGQEVSNAPQSTEQPPLAQMSELDRFGLAGLLRMIHSESPDVASLAVGQDLMTLGLDLNQAEPLHTSFASPFVSSMSAVPLEQDFSLPGCYNVANIQPLQSRIPGFSDETLFFIFYSMPRDIMQELVAEELMGRKWRYHKLERCWLTRDETYPGPVDVERGVTERGVYLLWDSSAWKKVRREFILRYEDLDNRLDPNRGAARPPGVVHHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PL44</accession>
    <name>A0A0G4PL44_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Enolase</fullName>
            <ecNumber evidence="4">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PCAMFM013_S021g000067</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Mg(2+) is required for catalysis and for stabilizing the dimer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="4"/>
    <dbReference type="EMBL" id="HG793154">
        <property type="protein sequence ID" value="CRL27152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PL44"/>
    <dbReference type="STRING" id="1429867.A0A0G4PL44"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.10:FF:000001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000002">
        <property type="entry name" value="Enolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902:SF1">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00178">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enolase N-terminal" evidence="16">
        <location>
            <begin position="3"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase C-terminal TIM barrel" evidence="15">
        <location>
            <begin position="143"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="374"/>
            <end position="377"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CRL27152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="438" mass="47297" checksum="A62443376703006C" modified="2015-09-16" version="1">MPISKIHARSVYDSRGNPTVEVDVVTETGLHRAIVPSGASTGQHEAVELRDGDKAKWGGKGVLNAVKNVNDVIGPALIKENLDVKEQAKVDEFLNKLDGTPNKGKLGANAILGVSLAIAKAAAAEKGVPLYAHISDLAGTKKPFVLPVPFQNVLNGGSHAGGRLAFQEFMIVPDTAPTFSEALRQGSEVYQKLKTLAKKKYGQSAGNVGDEGGVAPDIQTAEEALDLITDAIEQAGYTGQIKIAMDVASSEFYKEDAKKYDLDFKNPESDPTKWLTYEQLADLYKSLAAKYPIVSIEDPFAEDDWEAWSYFYKTSDFQIVGDDLTVTNPLRIKKAIELKSCNSLLLKVNQIGTLTESIQAAKDSYADGWGVMVSHRSGETEDVTIADIAVGLRAGQIKTGAPARSERLAKLNQILRIEEELGANAIYAGEKFRTAVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PM23</accession>
    <name>A0A0G4PM23_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonuclease II/R</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S022g000147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793155">
        <property type="protein sequence ID" value="CRL27467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PM23"/>
    <dbReference type="STRING" id="1429867.A0A0G4PM23"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056625">
        <property type="entry name" value="SH3_CYT4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056624">
        <property type="entry name" value="WH_CYT4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF65">
        <property type="entry name" value="EXORIBONUCLEASE CYT-4, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23214">
        <property type="entry name" value="SH3_CYT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23216">
        <property type="entry name" value="WHD_CYT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="2">
        <location>
            <begin position="547"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL27467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1096" mass="123585" checksum="72BBE9BA421FC157" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMC4</accession>
    <name>A0A0G4PMC4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-phosphoshikimate 1-carboxyvinyltransferase, core</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S023g000038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793156">
        <property type="protein sequence ID" value="CRL27580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PMC4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PMC4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196:SF1">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL27580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="293" mass="31017" checksum="9C5C2A28B0AC9FC6" modified="2015-09-16" version="1">MGFPPFTLKHHTAPYPGIDPSLPAVSAAGKTILITGGGSGIGPRIAEAFAVAGSTQITLLGRTQSTLEKTKTTLESTHNGLKVLTFVADISDASAVNAAFQDTKATFGPIDIFISNAAFFPEAVLIKDTVVSDFAQGLTTNVVGNLVTTQAFLATAAPSNAVLIHVTSGAVHMPSMPNYSGYQTSKTAALKFFEAVQAETPDLRVMNVHPGYIATDMNAKSAKGGLGSDNSIPFDHIDLAGHFMVWAASPEGAFLKGKLIWSNWDVEELKQRKEELQGGEKLTMVLNGWPRND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PN04</accession>
    <name>A0A0G4PN04_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aromatic-ring hydroxylase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S022g000203</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793155">
        <property type="protein sequence ID" value="CRL27523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PN04"/>
    <dbReference type="STRING" id="1429867.A0A0G4PN04"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000115">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF242">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="19"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL27523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="458" mass="50506" checksum="A719320B553CDBC6" modified="2015-09-16" version="1">MAPQIPIKEQELRSQSCQLNVVIVGAGLAGLGSAISCALAGHQVQVLEATREIKEVGAGIQILPNSSRVLQHWGIEKALTPHMTVPRVCNFLGWKGNHISSLDFHQSESNYPGTWYRDFHRADLQQCLVERALELGVNITCNARVADVTVSEDGTTATATAADGRQWIGDLVIGADGVFGKLTEGLLGRVDPPVKTGDLAYRLLLSTEEMRKDPDLAELVTDPQVNYWLGPDAHAVNYVLRGGELFNMVLLVPDDIPEESLASTIEGNVEEMCALFKDWDPRIPKLLKLCESVQKWRLCIRFGDFDWTHPSGAFVMLGDAVHATLPYLASGAGMSFEDGAVLGECLSRLPNSPSISKTSAEFLTAKQQALAIFQECRKQRTKMIVERGNIQQYLYHLHDGAEQEERDRKMQMVPTPEGEALAWRDPGLAPKLLGYDHIADVDRRWGKSIGTNVVESRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNI2</accession>
    <name>A0A0G4PNI2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lipase, class 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S025g000050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CRL27992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051299">
        <property type="entry name" value="AB_hydrolase_lip/est"/>
    </dbReference>
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        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005592">
        <property type="entry name" value="Mono/diacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640:SF1">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03893">
        <property type="entry name" value="Lipase3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
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    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195827" evidence="3">
        <location>
            <begin position="20"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Mono-/di-acylglycerol lipase N-terminal" evidence="5">
        <location>
            <begin position="12"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="4">
        <location>
            <begin position="104"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL27992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="294" mass="31375" checksum="73227C4AE92BD97D" modified="2015-09-16" version="1">MLCFGRLWGIAALAAVTVAAPSRSVPRDVSSSVLDQLTLFSQWAAASYCTNNDNSTGDAVSCEAGNCPLVESADTTTLYEFNESCSYGDVAGFFAVDKTNKLLVVSFRGTRTLATWIANINFGFTDASSICSDCEVHSGFLESWEVVADDLTSNIAAAQTTYPGYTLVITGHSFGGALATLGGTILRNAGYEPNVYTYGQPRVGNEALAEYITNQGSLWRVTHESDLVPKVPPSHIGFSHASPEYWITVGNDVTVTSSDIDVIEGVGSKAGNAGTLDPSIDEHRWYLGYISQCQ</sequence>
</entry>
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    <accession>A0A0G4PQZ4</accession>
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        </submittedName>
    </protein>
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    </gene>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793161">
        <property type="protein sequence ID" value="CRL28541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PQZ4"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="MJ1316"/>
    </dbReference>
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        <property type="entry name" value="MJ1316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MJ1316 RNA cyclic group end recognition" evidence="2">
        <location>
            <begin position="51"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL28541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="142" mass="16296" checksum="493AC4CACEC89BA6" modified="2015-09-16" version="1">MASNNPSKTDANMITGQEAAQFPSGSTISPRKRDQRSVSPEYDPKAGENRLRPAGDIINRITWDSAFERSNYIIGFVDRFEGQLEITMGSWKKETTDEEFIPQHRVLYIRHTNGEIVWDRRRRIDKIFLSGNSAFSELAFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PR20</accession>
    <name>A0A0G4PR20_PENC3</name>
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        <submittedName>
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        </submittedName>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
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        <property type="protein sequence ID" value="CRL28571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
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        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006144">
        <property type="entry name" value="PRK08294.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF10">
        <property type="entry name" value="2-MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="18"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="408"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL28571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="612" mass="67946" checksum="4A38B2E2F96C44BE" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRR0</accession>
    <name>A0A0G4PRR0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S033g000027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793166">
        <property type="protein sequence ID" value="CRL29107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PRR0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PRR0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436:SF3">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="POLYKETIDE CYCLASE SNOAL-LIKE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="8"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL29107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="468" mass="51825" checksum="71ECE3405E5CEEFD" modified="2015-09-16" version="1">MVNVFQRLTRRRAQSSGSNPADIDADSTGPNSAVSHPHGIHRTVSTSSAKRSWRYEEPAPRHLFLISDTVAFDTHVVHRFQGEGFDVIYIPFLGSGNEEKDAKALKKAVHDKEDELENGERYAIVAYHRPAYLLLALHHIVSSNTNPFPHLCALIAYYPLSSTDQFTYREKDNCEAPGCSDTSSIFGPTSKSTYLPIQIHIPGPRVQPCALWPWIGISLTEGDVTYKKKHRCYVYTYPGSRSGFAEREIAEEKEGEVDSQLNIDDEIGSQLAWSRVLGCLRRSFNVGSHWAVTDIETVWEEYWDHVVGELELRKRHLEGSGSEPAVAMLTGHGHYGEVGCPAGEVFVKCIPTDAGGSDISTLRDFFAHAYIPAGPVDQNVRLLSRTVGVDRIVDEMLFACQHTAEIPWLLPGVPPTNREIKVIVVVVASFSASQITRQSLYWDQAGVLVQVGLLDPGLVPTSKAAKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRT8</accession>
    <name>A0A0G4PRT8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S033g000079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793166">
        <property type="protein sequence ID" value="CRL29159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PRT8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PRT8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL29159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="78" mass="8755" checksum="8035FA0E66886732" modified="2015-09-16" version="1">MEIPEPKRLSQVATDAETLDHARKSFDTIFHDSYTCETVLPNITQAVVDSKVQVIGADPCGFHTFPPFTLRHMQILPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PS42</accession>
    <name>A0A0G4PS42_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S031g000126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793164">
        <property type="protein sequence ID" value="CRL28958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PS42"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL28958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="56" mass="6146" checksum="F9B3489CD4858B2D" modified="2015-09-16" version="1">MEIDEGSVVFNGDARGKHSDGTQVHMISGGSVKNKSTLFNCDLDPESFKKIFGEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PSQ5</accession>
    <name>A0A0G4PSQ5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alanyl-tRNA synthetase, class IIc</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S033g000118</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793166">
        <property type="protein sequence ID" value="CRL29198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PSQ5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PSQ5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000008">
        <property type="entry name" value="Similar to alanyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051335">
        <property type="entry name" value="Alanyl-tRNA_Editing_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462">
        <property type="entry name" value="ALANYL-TRNA EDITING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462:SF2">
        <property type="entry name" value="THREONYL AND ALANYL TRNA SYNTHETASE SECOND ADDITIONAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="4">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL29198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="266" mass="29320" checksum="4BC5FAAC367B5F3C" modified="2015-09-16" version="1">MTSPRTILVFQHDASLHILETTVTAIIPFNALEESSRILFKDASEEHHVIVTEKTIFHPQGGGQPSDTGVLNGPSGTFTVTAVRTDANGQVLHLGLFENSSSTFKKGETVQQAIDVEKRLLYSRLHTAGHVLGASVRHLLEKEIQNFDELKASHFPDSAACEFQGSIDGKWKDSIQNKLDTYVAAKMPVQIEWWDEEDFRSRGLERLIPDRSLVPAGEKSRVVNIVGAEVYPCGGTHVDTTDLCGPVTVKKISRKQGNSRVSYAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PSU3</accession>
    <name>A0A0G4PSU3_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein SIP5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Protein sip5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S037g000031</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May negatively regulate the SNF1 kinase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SIP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793170">
        <property type="protein sequence ID" value="CRL29544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PSU3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PSU3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24139">
        <property type="entry name" value="SIP5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039301">
        <property type="entry name" value="Sip5/DA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31315">
        <property type="entry name" value="PROTEIN SIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31315:SF1">
        <property type="entry name" value="PROTEIN SIP5"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL29328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="717" mass="79546" checksum="570AFA480E9DA031" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PTC7</accession>
    <name>A0A0G4PTC7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S035g000041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793168">
        <property type="protein sequence ID" value="CRL29346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PTC7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15517">
        <property type="entry name" value="PHD_TCF19_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL29346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="526" mass="59553" checksum="88FC857E27B5F295" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PTF4</accession>
    <name>A0A0G4PTF4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S039g000002</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HG793172">
        <property type="protein sequence ID" value="CRL29693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PTF4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PTF4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF558">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="92"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL29693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="377" mass="43527" checksum="A78F8300F95C001A" modified="2015-09-16" version="1">MLPRPTTTIRKRGFGNRRFMLENGDHHHFLRLPPSKRQFLKKNRNTSWISFKKRTKACSQPSADLEWEQWTASQQTGIVAGEKMAILAQKYGDICDIVGHGSSGIVLLSRKAQEWNPNIHRFYALKVFCRGAESTETAYRRRVESEFYISSSLQHQNIVRTFELLQIGNDSLCECLEYCSGGDLHSLVVTSGQLEKAEGDCLFKQLMRGVNYIHEMGIAHRDLKAENLLLSPNGCLKISDFGSAECFRLGWETHIHMSRTRRGSRPFVSPEQYFCEEFDPRSVDIWAAAITYIVMRTGRIPWKIATDQDEYFRDYVADRTVEKGYFFIEEICNIASRRVIYSMLDIDYVCRPISTEILDSRWLQETKTCTAAESRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PU37</accession>
    <name>A0A0G4PU37_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">3-hydroxyacid dehydrogenase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S038g000074</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the four-carbon acid sugar kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793171">
        <property type="protein sequence ID" value="CRL29671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PU37"/>
    <dbReference type="STRING" id="1429867.A0A0G4PU37"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.20">
        <property type="entry name" value="Four-carbon acid sugar kinase, nucleotide binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10840">
        <property type="entry name" value="Putative sugar-binding, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010737">
        <property type="entry name" value="4-carb_acid_sugar_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037051">
        <property type="entry name" value="4-carb_acid_sugar_kinase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031475">
        <property type="entry name" value="NBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042213">
        <property type="entry name" value="NBD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17042">
        <property type="entry name" value="NBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07005">
        <property type="entry name" value="SBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142764">
        <property type="entry name" value="YgbK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Four-carbon acid sugar kinase N-terminal" evidence="7">
        <location>
            <begin position="42"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Four-carbon acid sugar kinase nucleotide binding" evidence="8">
        <location>
            <begin position="304"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL29671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="480" mass="51359" checksum="0CD0EB34F68B2731" modified="2015-09-16" version="1">MSQPEYPVLSRENTLANLPAEYPTDAQEQITQILTTAPINRLVVLDDDPTGTQTCHDISVLTVWDIPTLTAEFQSAKPGFFILTNSRALPPKEAETLIHEICTNIAQVAKTTNQKVDIVLRGDSTLRGHFPLETDVAQSVFGPADALVLAPFFFQGGRLTIDDVHYVTEGDSLVPAGATQFAKDATFGYRSSNLRDYVLEKAPGRFNADQLCSVTIEEIRTGGPQAVCKKLLSAPAGGVVIVNAAAESDMHVFVAGLLLAESNGRHFLYRTGAAFVSTRLGIRSKAPISAAELHLPSPRQTGGLIIAGSYVPKTTAQLKVLTDRRGASGQLAIIEMKVEELIASPETAGQAVLRVVQETESHLRAGMDTLVMTSRALVTGGDELSSLKIGSVVAEALVGVLRRIEVQPRFIIAKGGITSSDAATKGLNIKRATIVGQAAPGVPLWRCDEETSRHRSVPFVVFPGNVGGEETLCELVEGWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUL6</accession>
    <name>A0A0G4PUL6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fatty acid hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S044g000044</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793177">
        <property type="protein sequence ID" value="CRL30113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PUL6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PUL6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="175"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL30113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="350" mass="41163" checksum="9594F7A49B2D6405" modified="2015-09-16" version="1">MDIILELWDTFIGDRLYSTLLPASLSSSVSLPAFVNAAANTSMALFGPEPYVYEQATQMIYLEPSKYAYLSAWPRNNVYRQFTSFFLITWLFGLLVYFLVATLSYIFIWDKTTYNHPKFLKNQIGLEIRQAMAAMPPMSLLTAPFFVLEVRGYAKLYDTTAEEPFPYYSLIQIPFFICFTDFFIYWIHRGLHHPRVYKTLHKPHHKWIMPSPYASHAFHPLDGWSQSVPYHVFPFIFPLQKFAYVFLFGFINLWTVFIHDGEYVANSPIVNGAACHTMHHLYFNYNYGQFTTLWDRLGGSYRKPNEELFRRETKMGDKEWKRQAKEMESILKDVEGEDDRSYSADKKKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVN0</accession>
    <name>A0A0G4PVN0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">B-block binding subunit of TFIIIC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S052g000005</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793185">
        <property type="protein sequence ID" value="CRL30448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PVN0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PVN0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042791">
        <property type="term" value="P:5S class rRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044210">
        <property type="entry name" value="Tfc3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007309">
        <property type="entry name" value="TFIIIC_Bblock-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04182">
        <property type="entry name" value="B-block_TFIIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="B-block binding subunit of TFIIIC" evidence="7">
        <location>
            <begin position="133"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="314"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL30448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="394" mass="45252" checksum="2839EDC979A1D2DB" modified="2015-09-16" version="1">MPGVQHLIDFVLNEVALRGNQGATLSDLLQAIDDFHAQTPEINQNIDHRFKSKIWSWLTTNPEVSIGQHNKWNHLTLSEAEQLDSRKTERDDPEVNQTADETPDSPPLRIFVSEERTWVAITGHPPDESKVLPLEFVLLSVIASRRSKGIVQPELVKLSGQDKRSVPKRTDALQRKGYIDKRPVQTKTARTSLCTLQRFYRHTTSVQTKEEPQSKNMIDFDSFNSSLFNILREHQLIARNDLKQLLGFDDHWRWKVLSRALRKWERIGVVQRVRAESQYERMHPCVKLLRDPSEQDLALFHEFNFDVLNKHGVRSKGPRLTPDRDHSMEVEGPSKRSPSPEDGRMDLIKEHVGESARIVPSWTPDRNLNNQIFDIIQSTGTTGITNQASTSSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PWN7</accession>
    <name>A0A0G4PWN7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S060g000030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793193">
        <property type="protein sequence ID" value="CRL30820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PWN7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PWN7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="60" mass="6393" checksum="E43E5A70CC62D9AD" modified="2015-09-16" version="1">MPLSLLVNLKDGPVPKTLSLVQALNEFSRNGKDVGLTLASLPAPTADPDDAYELEKSKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PX71</accession>
    <name>A0A0G4PX71_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S060g000011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793193">
        <property type="protein sequence ID" value="CRL30801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PX71"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL30801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="223" mass="25374" checksum="35407FE1666A0681" modified="2015-09-16" version="1">MSSNLTTRKPRSRRPKLEEHAAIEKLRNISSLVYQRRFLKDHERKRASEALALMAAEPIDDKYQRFLFNVKRESKLENSAPLATLCAIALGKDVIKSAKEDILMNLPQKIAALEADLVNDVLKGDLANTKETAFQTPSELSHDIFAHDRESVPLDLQLGELIDFLREYEGLDKTLRMSFPLSGHPLPSIYFASQQPGYADAKVEFSQPLATTFIRHVMKRRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PX85</accession>
    <name>A0A0G4PX85_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S075g000011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793207">
        <property type="protein sequence ID" value="CRL31107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PX85"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL31107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="105" mass="11540" checksum="425EB9657620E6A6" modified="2015-09-16" version="1">MYMRGRPRAADWPIEPGEYILHIAVANPVQRGADLAEEYKMMADGRCPTSPELTELVKAPLKVYSGSSNVTIALRLLPHITFQMRLECSLVLQPPMASTGSLLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PY42</accession>
    <name>A0A0G4PY42_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S071g000001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793204">
        <property type="protein sequence ID" value="CRL31064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PY42"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL31064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="87" mass="9759" checksum="0CA4B9942AFB1264" modified="2015-09-16" version="1">MVNGSDFKNPNTEDGQNDPPEIKDPAGSDDIDERMTRDYKEAIDKAKANKDRLPHAKPSSTGHHEPTEDGNDISWRPDPSGNPWRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PY75</accession>
    <name>A0A0G4PY75_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S117g000001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793248">
        <property type="protein sequence ID" value="CRL31317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PY75"/>
    <dbReference type="STRING" id="1429867.A0A0G4PY75"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL31317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="105" mass="11964" checksum="739EB2B73CD852BC" modified="2015-09-16" version="1">MPYKSLLENAAAVAAAKVRSQITRTSHDRYPWLFVSPRSKEDVRPVVECLLEDKAKLQSISSKTSITFPEDPWRAVVDYYPVVWTKRAGKLEPPFPGKHLVITPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PYC8</accession>
    <name>A0A0G4PYC8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S082g000018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793213">
        <property type="protein sequence ID" value="CRL31171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PYC8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL31171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="122" mass="13809" checksum="A89E5BC99D67AD93" modified="2015-09-16" version="1">MLTSSKSPLAFPNELNWVDFRLVRFDRKSGESIGQHLFFLPRVETGTWNLRRVRGQLLDTISRHGIGAIGTRFRLSLWPRMEPVPHSSHLSLPLLAVIPTTASLDPRVLCTTYWVTTSEVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PYE4</accession>
    <name>A0A0G4PYE4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S4Jg000045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793313">
        <property type="protein sequence ID" value="CRL31523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PYE4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL31523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="248" mass="27495" checksum="9BE3EE39E1E8A2D0" modified="2015-09-16" version="1">MTVQSVCHRRNDMFGYKSVNVHGLVGAFMFIKVNHTLSKQIAGTLDVRFVDRIQQDILEHRNDTEYDILYLTPVPDSNHDFRVRIEDFQSLDLDNSDQWSQRLRTAYAHINQRHPLGVPFINLALGFFLSAALVQGASIPNVEQRNNTNALNTRAGNDYRIAVYQNGQCTGEAIPYSGDDEDCHNGLGNGGAGLQLLALDADGMLVFYGAADCPAGQEVDTFNPDQDQTGTDCKPLNGNPVSFQFIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PYI8</accession>
    <name>A0A0G4PYI8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S3Jg000010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793312">
        <property type="protein sequence ID" value="CRL31399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PYI8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PYI8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="CRL31399.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">FM 013</strain>
        </source>
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        <source>
            <dbReference type="EMBL" id="CRL31231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="41" mass="4445" checksum="59ABEDDCBD30EA33" modified="2015-09-16" version="1">MYFLGIPLNNISRSCNYCLQCFAPVTVFIVGVPAPSLPLSV</sequence>
</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
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                <person name="Conseiller E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL31486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="647" mass="73219" checksum="BAB7B86219BDE491" modified="2015-09-16" version="1"> </sequence>
</entry>
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    <accession>A0A0G4PYU5</accession>
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    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S123g000002</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
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                <person name="Debuchy R."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
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        <location>
            <begin position="50"/>
            <end position="82"/>
        </location>
    </feature>
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            <end position="263"/>
        </location>
    </feature>
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            <end position="369"/>
        </location>
    </feature>
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        <location>
            <begin position="369"/>
            <end position="401"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL31337.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="493" mass="54773" checksum="1B4716E6D257FE0B" modified="2015-09-16" version="1">MPNIRDLPTELLMWIVSYLNGSAIFSLARSCTILYSRLQPSIWKYNVKFQNSNLLHLAAKTGNVRFAEALLRHNANINAFYRGKTPLMRALQYPSTAVRELLLSHRELDINLQNQARDSALWYAIHYGNSSIVKSMLDHPASRANIKHKHGRTALHLAVFAGRIGFACHFNRPVMKAMFQHEVDSAVFLGTQLSRDAELPLHQAVSYGSIDAVKRLIKRKRAKLHIQDHNGDTPLHLAVQSRSLEMVDLLLSHPGADVNCKDKAGNTLLWLSTHSSCNQITERLLAEKDVDINFIGGHRNCLRSSTSLHHAVTGVDTVALQLLLATPGIDVNICVAGQSPLYTAAGHGRVNVVAMLLKVEGVEINGRGLSDPPLCRAVERGHLDVVRLLVQQGTCLDINESASTSHDTALCIAARGGNLEMVQALLRHDQIDVNIRNRWFEDPLMLAVKGGHTLVVNALVDDHRMKRFTLNRSLDLARGSRKRTKPLILSTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NSV7</accession>
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        </recommendedName>
    </protein>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
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                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(R)-mevalonate + 2 NADP(+) + CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15989"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="9"/>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NSV7"/>
    <dbReference type="STRING" id="1429867.A0A0G4NSV7"/>
    <dbReference type="UniPathway" id="UPA00058">
        <property type="reaction ID" value="UER00103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF24">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0521">NADP</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
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        <location>
            <begin position="243"/>
            <end position="421"/>
        </location>
    </feature>
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        <location>
            <begin position="1102"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1103"/>
            <end position="1121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1128" mass="121002" checksum="CD383F38FA1701AD" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NT94</accession>
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        <alternativeName>
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        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Diphthamide synthetase</fullName>
        </alternativeName>
    </protein>
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        <name evidence="7" type="ORF">PCAMFM013_S001g000267</name>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphthine-[translation elongation factor 2] + NH4(+) + ATP = diphthamide-[translation elongation factor 2] + AMP + diphosphate + H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10174"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16692"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
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            <dbReference type="EC" id="6.3.1.14"/>
        </reaction>
    </comment>
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    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-binding domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="putative n-type atp pyrophosphatase, domain 2"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
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        <property type="entry name" value="MJ0570_dom"/>
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    </dbReference>
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        <property type="entry name" value="DIPHTHINE--AMMONIA LIGASE"/>
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    </dbReference>
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        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION 71 DUF71 -CONTAINING PROTEIN"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="11"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL17307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="762" mass="83164" checksum="B3522900BD864454" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NU93</accession>
    <name>A0A0G4NU93_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase, F0 complex, subunit J</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S001g000616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NU93"/>
    <dbReference type="STRING" id="1429867.A0A0G4NU93"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006995">
        <property type="entry name" value="ATP_synth_F0_jsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28060">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT J, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28060:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT J, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04911">
        <property type="entry name" value="ATP-synt_J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Lacoste S."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
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            <end position="412"/>
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            <end position="35"/>
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    </feature>
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            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <end position="104"/>
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            <end position="400"/>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="CRL17720.1"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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</entry>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL17792.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NUQ5</accession>
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            <fullName evidence="9">Sucrose/H+ symporter, plant</fullName>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Dupont J."/>
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                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">FM 013</strain>
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        </subcellularLocation>
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        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF1">
        <property type="entry name" value="ALLANTOATE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="328"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="351"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="410"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="439"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="476"/>
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    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="68"/>
            <end position="483"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL17815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="517" mass="58324" checksum="57556BA7A86CE7E8" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NV35</accession>
    <name>A0A0G4NV35_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S001g000898</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NV35"/>
    <dbReference type="STRING" id="1429867.A0A0G4NV35"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043323">
        <property type="entry name" value="PIN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45995">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13616">
        <property type="entry name" value="Rotamase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PpiC" evidence="8">
        <location>
            <begin position="35"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL17938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="129" mass="13853" checksum="90B8E7CF16446186" modified="2015-09-16" version="1">MAPKNNAKTAKGKGKDTSADDAKGKGGKGGAVKGAQSINVRHILCEKHAKKEEALEKLRNGTKFDEVAREFSEDKARQGGSLGWKTKGGLDPAFENVAFELETSTTGNPKYAEVKTGFGYHIIMVEGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NW13</accession>
    <name>A0A0G4NW13_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S002g000115</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NW13"/>
    <dbReference type="STRING" id="1429867.A0A0G4NW13"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL18245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="179" mass="19694" checksum="61EC21F6ED85D89D" modified="2015-09-16" version="1">MSSRVGFRFVNNARFAFRNASAPFRRPGAQGFRWQSSEAGAGEQQNAFQRLWNSPVGMKTVHFWAPVMKWCLVIAGISDFARPAEKLSLTQNAALMGTGAIWTRWCLIIKPRNVLLAAVNFFLGCVGAVQVTRIFMWQRSQSDSTLEAAKEIEHEAVDSVKATAGAAEGAVKKAIEKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWB5</accession>
    <name>A0A0G4NWB5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S002g000215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWB5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL18345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="118" mass="13226" checksum="329455B846BFA4B8" modified="2015-09-16" version="1">MSAPKGPFHLVSVNTAPERAKRLIGRLVEALSDRYTIIHVDNCEKIDEVEAKVKQHNPEVLFSASMWSPEEAEQIHQIARSVRPDIKLHAIPQGLQVERGPDAVVEYLLENVPVLLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWR0</accession>
    <name>A0A0G4NWR0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S002g000239</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWR0"/>
    <dbReference type="STRING" id="1429867.A0A0G4NWR0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF74">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="39"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL18369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="493" mass="54178" checksum="887C210B9AABC553" modified="2015-09-16" version="1">MSGKDVSQESIKISDVSSFDWASDTRNPHNWSGAKKAFVFLTTMLVVLNSSMGSSLTGNAIQSITKEFGVESQLQKALPMSIFLVGYVFGPIVWAPLSEEFGRRLIAITTFPLFAIFTMACALAPTWSSFLIFRLFAGTFGSAIVALGPGILADIYQDPQARGWSIAVFMAVTGFGPMLGPIVSGFTSPALGWRWSFWVALIFAGVTHIFVVWFPETYGKTIAAKYTPENLMISQPTSINKQHRSWRRIISDVLLRPLHLLVTEPIVTACSMYLALCYSIFYMSFQVFPEVFQHLYGLSPGQCGLVQLAIGAGCVLSLPIYWVYEQILRRVLRSSPGKLKQEYYRLPLACLGGPLFVISLFWLGWSSRLDVPFAVPMIAGIPFGMGFMCIFIAILNYVTDAYQVFAASANAASSCSRSFLATFLPLASYPMLSHLGIAGTCSLLGGLSALMSVIPFLLIWKGEAIRSRSHFCNTLDDQHKNTRQSPSPVVGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NY14</accession>
    <name>A0A0G4NY14_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S002g000816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NY14"/>
    <dbReference type="STRING" id="1429867.A0A0G4NY14"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021838">
        <property type="entry name" value="DUF3431"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF3">
        <property type="entry name" value="DUF3431 DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11913">
        <property type="entry name" value="DUF3431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL18946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="381" mass="42328" checksum="EA311EE2916380D9" modified="2015-09-16" version="1">MGRKVQRSVIQLIFFLCILFCILYLNRPQSTKDKLFAWTKIRYKTTSSIIPEARGVCPGLAGTTKPALIVSHVSTDGDPSWLEPLRTQYHVCMYQVDAPADKTSKLLQVPANRGHEAMAYLTFLIDNYADIPSAGAVFVHGSRWAWHNDIPDYDNLALLRSLDVRAALKPAGYSNLRCDWSAGTCPSSVPAQGSLEMRLSSAVSPWSPRSASDIALPKALGHIFGGDADARVEEIRNAFHLQLGRNDAVRAQCCAQFVVSRERIWQHGRDEYIALRQWLLDGSDDGVARNSQRGSRAAPGDDRVAGRIVSYLWHILFANYGDNGGIDLDQLNRDACPTASECYCRLYGKCDLTCRGPGSCKGQYSVPKDYKLPEDWEKTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZE5</accession>
    <name>A0A0G4NZE5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Purine nucleoside permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S003g000228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Nucleoside permease that transports adenosine and guanosine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NUP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZE5"/>
    <dbReference type="STRING" id="1429867.A0A0G4NZE5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009486">
        <property type="entry name" value="Pur_nuclsid_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38643">
        <property type="entry name" value="PURINE NUCLEOSIDE PERMEASE C285.05-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38643:SF1">
        <property type="entry name" value="PURINE NUCLEOSIDE PERMEASE C285.05-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06516">
        <property type="entry name" value="NUP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013171">
        <property type="entry name" value="Pur_nuclsid_perm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005194905" evidence="2">
        <location>
            <begin position="22"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR013171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL19437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="375" mass="40448" checksum="38A9B90904BF02F9" modified="2015-09-16" version="1">MGTKYLAILAFAACILRSVTAAPSLSLEKDVRHGVIAPKVVIISMFSLEAAIWPEQLGLYARNITTPGLSPEYPVVHCDIKGEICQLTTGEGEINAASTIMAFALSRHFDLSYTYFLIAGIAGVNPFYATTGSVTFARYAVQVALQYEIDIRELPSNYSTGYIPQHSTVPETYPETVYGTEVFEVNAALRDRAIALAKKATLNDTVEAAAYREKYNYSPANQPPAVVACDTATSDVYFSGNLLSESFGNYTAVLTNGTGVYCSSQQEDNATLESLLRADSAGLVDFSRIIIMRAGSDFDRPPPSETAAYHLLEASQSGTTPALENLYLAGVQIINDVKGNWTDYKYGIKPDNYVGDILNSSGSTTVMDFGPGSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZE6</accession>
    <name>A0A0G4NZE6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Zinc finger, C2H2-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S003g000170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZE6"/>
    <dbReference type="STRING" id="1429867.A0A0G4NZE6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021842">
        <property type="entry name" value="DUF3435"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535">
        <property type="entry name" value="FLUG DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535:SF4">
        <property type="entry name" value="FLUG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11917">
        <property type="entry name" value="DUF3435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL19379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="654" mass="75999" checksum="57460BF981F50A25" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZK2</accession>
    <name>A0A0G4NZK2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S003g000278</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL19732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1056" mass="113865" checksum="D4D2F5EA8B3DC943" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0C7</accession>
    <name>A0A0G4P0C7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S003g000577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P0C7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL19786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="253" mass="29532" checksum="74EAD70B280EB39D" modified="2015-09-16" version="1">MASLIQPTNGPPRANRSGKEDRSKSRMAKNVADEDIPQYVKRTVDLDQQLVKQTKYEVYINPGQEALYQIVDIYFLGYDWVLQWSETNGKDSPVEKEFEREIVLRNKTGSEFNITFSLGAEFKGLSMNLETSYKSFTESELSDGRKTREKFIVDPHTSTYYYQKRYNFRTEVWFKIDMRGQLYTVGQWKRDGVAIAVSSFCVESEERVGAPKEIKGEKSLKVEHIESKETQDNVIRFDDMTRRAHTWLHAHKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-11-27" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0Z9</accession>
    <name>A0A0G4P0Z9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S003g000783</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the 2nd section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the shikimate kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P0Z9"/>
    <dbReference type="STRING" id="1429867.A0A0G4P0Z9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000260">
        <property type="entry name" value="Quinate repressor protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000386">
        <property type="entry name" value="Quinate repressor protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090">
        <property type="entry name" value="AROM/DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090:SF17">
        <property type="entry name" value="QUINATE REPRESSOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="5">
        <location>
            <begin position="495"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase" evidence="4">
        <location>
            <begin position="633"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL19991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="835" mass="92970" checksum="D1B528DFBD9F9521" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P1N3</accession>
    <name>A0A0G4P1N3_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="3">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S004g000134</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="3"/>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P1N3"/>
    <dbReference type="STRING" id="1429867.A0A0G4P1N3"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01414">
        <property type="entry name" value="SAICAR_synt_Sc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000392">
        <property type="entry name" value="Phosphoribosylaminoimidazole-succinocarboxamide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000015">
        <property type="entry name" value="Phosphoribosylaminoimidazole-succinocarboxamide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010568">
        <property type="entry name" value="PRK13961.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR synthetase/ADE2 N-terminal" evidence="10">
        <location>
            <begin position="17"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL20194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="301" mass="33447" checksum="356308D9CBDCCE1E" modified="2015-09-16" version="1">MAQALTTTDLQGALPLIARGKVRDLYEIDDKTLLFVASDRISAYDVIMENGIPNKGVLLTLCTQTWFKALTEANPSLRTHFITLDLPPQIPESLRPILQNRSMQVRKLRILPIEAIVRGYITGSAWNEYKKSGTVHGIKVPAGLQESQAFPDGPIYTPSTKAEQGEHDENIHPDQAVAILGEPYASTVAKMAVELYKTAHEYALERGVIIADTKFEFGVDEETGEVVLADEVLTPDSSRFWPKESYAIGRGQASFDKQFLRDWLVSEGLKGKEGVRMPDDIALKTAEKYQEAWEKITGGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P255</accession>
    <name>A0A0G4P255_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S004g000342</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4P255"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022099">
        <property type="entry name" value="DUF3638"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022105">
        <property type="entry name" value="DUF3645"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046541">
        <property type="entry name" value="DUF6606"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051346">
        <property type="entry name" value="OTU_Deubiquitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367:SF33">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367">
        <property type="entry name" value="UBIQUITIN THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12340">
        <property type="entry name" value="DUF3638"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12359">
        <property type="entry name" value="DUF3645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20255">
        <property type="entry name" value="DUF6606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DUF6606" evidence="9">
        <location>
            <begin position="31"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3638" evidence="7">
        <location>
            <begin position="1350"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3638" evidence="7">
        <location>
            <begin position="1400"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3645" evidence="8">
        <location>
            <begin position="1626"/>
            <end position="1657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL20402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="2374" mass="270300" checksum="D6CD4C3E6C109BA6" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2E1</accession>
    <name>A0A0G4P2E1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translation machinery-associated protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S004g000437</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMA16 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P2E1"/>
    <dbReference type="STRING" id="1429867.A0A0G4P2E1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.170">
        <property type="entry name" value="Translation machinery-associated protein 16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021346">
        <property type="entry name" value="Tma16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038356">
        <property type="entry name" value="Tma16_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349:SF2">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11176">
        <property type="entry name" value="Tma16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL20496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="20742" checksum="A438DA482D8C35F6" modified="2015-09-16" version="1">MPVTLEKVHKQISKKRSSTNALHENSRDAHRLRKAGARDDRLSRHNATVNRARQPYLDRIDYIYEAIQELTEALSTEEISEFVAKYIERDTEEIKQLESERRKGRPPSKREEALKQRVQTEDREFSTGLWMPDLGDQYAMTAMKNWNGHWSGLSAIKFMRFTKAGEKLTSTFPPKSMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2F3</accession>
    <name>A0A0G4P2F3_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S004g000447</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P2F3"/>
    <dbReference type="STRING" id="1429867.A0A0G4P2F3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000058">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="15"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="638"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="692"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="647"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="723"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL20506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="742" mass="81192" checksum="567B6598F5030420" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2K6</accession>
    <name>A0A0G4P2K6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S004g000419</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P2K6"/>
    <dbReference type="STRING" id="1429867.A0A0G4P2K6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL20478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="256" mass="26539" checksum="4D9317B73755F3DF" modified="2015-09-16" version="1">MDSVKGKVYAVTGLGGIGLAVARQLHAQGALLSLADLSEQVLSTARQTIETEFGASTASTITTTALDISNVTAVQDWIASTVSHFGRLDGAANMAGTIGKQHGTGKFVDQDDAEWDMLMRVNVTGLMYCLRAQLRAITATAPGGRGSIVNASSIQGIKGFPLHAAYSTTKHAVSGLTKSVSKEVGPEIRVNAVAPGSIQTPLLEMAKEIQGGISIPPVSIPRIGTGEEVAQTVVFLLSDASSYTTGQILSVDGGWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2W6</accession>
    <name>A0A0G4P2W6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S004g000607</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P2W6"/>
    <dbReference type="STRING" id="1429867.A0A0G4P2W6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="27"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="350"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="380"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL20666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="399" mass="43552" checksum="484365914327585C" modified="2015-09-16" version="1">MIDDHYQKTALGIVVAFTILGGIAVLLRLWSRWLSRSALTSDDYLIVVGYIIAISQSVTSWFFIKTNYIGIHIWDVPENYNPRPGLNWNFANQLLYNPALTVVKLSILLFLRRLDSRSRVVKYLIWSSFAIVTSLFITVLLVDIFQCNPVPYVYDTTIPGGKCINQGAFYVSTAALNLFTDIMVLSIPVIITARLQMPLRRKIAVCIILCLGGVATAVGVWRIIILAQGFLSDTPNPDPTYSIAFCSSAVEVNVAVVTACGPSLKAISSRFLPRLLGSSRNGKSTYGAGTGSGTGVGSRRLRSNIFKSKSASHAQPSLYSARGPDYEMADPLGGPRVDIVGDFEMRKYKRGDDSSNGSLSDDGKGIMKTTDISVGYSVEPRVDGRSQEGRRPASVDSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3H8</accession>
    <name>A0A0G4P3H8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase, DXD sugar-binding region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S005g000023</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL20859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P3H8"/>
    <dbReference type="STRING" id="1429867.A0A0G4P3H8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF8">
        <property type="entry name" value="TRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL20859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="436" mass="49322" checksum="324A49876F7377FC" modified="2015-09-16" version="1">MLSITNLNNSRALRLVVPIVVVFALAYTFYADWKPVQRVISSSNPSSGAIVTGDGSSAPSPSKSKFHHSNANTSISNIPDKVWHSAKTDDISENQRKWVNSWSSTTPECRQELLTDRSGEAFVRAYYQEMRPDIVEVIESLSIPILRADLLRYLIVLAEGGYWSDLDVTLEKPLSDWVPTEYKDQNIDMIVGLEFDFAYRGPEAEVASQFCNWVFAAQPSSRNLLVIVNAVINKLKEIARTNNVSISGITLEMLKDVVNVTGPKIMTIAILESLGQLLNRTVDDRDFSGIKHPKMVGDVLIMPGVSFAAAQNGFPTDQGDVLVTHHYEGSWKQADAEAKERKKQQEQEGHEAQTETFRPLYYLTGRPVDDITGEHFEAFREVYKEFVDSFKEEKRFPPINSVYPYRTTLIRDGWKTGSFWYFHTLESSNGLFNLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3Y1</accession>
    <name>A0A0G4P3Y1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S005g000168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P3Y1"/>
    <dbReference type="STRING" id="1429867.A0A0G4P3Y1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL21004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="181" mass="19953" checksum="BDFC1C5022A6658F" modified="2015-09-16" version="1">MSSISIRLPNVYARSGASSAPPTDFIIGTWHVAHSTLPLWKGKRNVNITYKLLPADSAGVQKIDDLVQYQSIDSEKIKSVHGVDTPTPGTPGAWDWRGKGWLMIASSHWECLGFGHTDDDNQWIVTYFDKTLFTPAGVDIYSRNKDGLPQTTVDQILDALKGLGVDDITDLANRGFQIPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P422</accession>
    <name>A0A0G4P422_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">H/ACA ribonucleoprotein complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S005g000218</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Non-catalytic component of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of rRNA and is required for ribosome biogenesis. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs. The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs. The H/ACA snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 10">Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 10">Belongs to the GAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P422"/>
    <dbReference type="STRING" id="1429867.A0A0G4P422"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034513">
        <property type="term" value="F:box H/ACA snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000454">
        <property type="term" value="P:snoRNA guided rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.230:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237:SF6">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237">
        <property type="entry name" value="NUCLEOLAR PROTEIN FAMILY A MEMBER 1 SNORNP PROTEIN GAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="121"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="138"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL21054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="214" mass="21386" checksum="D9618F64B9FFB59D" modified="2015-09-16" version="1">MSFRGRGNASGANRGGFGGGRGGRGGFQQSFGPPAQVLELGSVMHSCEGEMVCESVNPKIPYFNAPIYLENKTQIGKVDEILGPINQVYFTVKPQDGIVATSFKAGDKVYIGGDKLLPLEKFLPKPKPPPGAAKPKRAGGGAPRGRGGFGAPRGRGGFGARGGAPRGRGGFGGGRGGGGFGGGRGGGFGGSGGFSRGGGRGAPRGGGGFRGRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P4A3</accession>
    <name>A0A0G4P4A3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S005g000266</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P4A3"/>
    <dbReference type="STRING" id="1429867.A0A0G4P4A3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374:SF1">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE PAD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="24"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="64"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL21102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="623" mass="70436" checksum="1765FAC5C0DD2D16" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P4K5</accession>
    <name>A0A0G4P4K5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S005g000376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P4K5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL21212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="37" mass="4216" checksum="8ECC3AA5B371024F" modified="2015-09-16" version="1">METGTQKHRLGIGQYHVLMFVQQEALIQSLRFVVISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P4Y5</accession>
    <name>A0A0G4P4Y5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynactin subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S005g000529</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P4Y5"/>
    <dbReference type="STRING" id="1429867.A0A0G4P4Y5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027777">
        <property type="entry name" value="DCTN6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072">
        <property type="entry name" value="DYNACTIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072:SF0">
        <property type="entry name" value="DYNACTIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="84"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL21365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="252" mass="25897" checksum="43D6DCB385A5AE0F" modified="2015-09-16" version="1">MATLKPPTNTHRSSSSSSHSSGPPKAPLKADPTATIADTVVFQGRHPVTIGAGTVIHPRAKFYAYEGPIVVDDGCIISEKAVIGAPPSSSRSPSPSRPASTTPTESGASTPEPRKETSTRISYFVTVGPLATVEPGAHIHSSATIEALATIRRGADIGAHSKVCSGCEIAAGGSVAEWVVVYGQGPGMRRKRARGVKGMSPAVVGAAQVSQTSLPGPAPAGKVIEDARLMVLQKEREVLGRMLVPAAGGRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P542</accession>
    <name>A0A0G4P542_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme E2 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S005g000582</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P542"/>
    <dbReference type="STRING" id="1429867.A0A0G4P542"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23795">
        <property type="entry name" value="UBCc_UBE2G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000048">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="5"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL21418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="167" mass="19078" checksum="BD93D5CE1C1C4B66" modified="2015-09-16" version="1">MATSPAGRMLSRQLQQMQSDKDIPGISCGLVDNNVFEWEVMLMISDDVKLYGGGFFRARLSFPTEYPHRPPKMKFESPIFHPNIYENGDVCISILHPPEEDKYGYESAAERWSPVQTPETILLSVISMLSSPNDESPANVEAARLWREDPAEFKKRVRRCVRLTLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5D7</accession>
    <name>A0A0G4P5D7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Basic-leucine zipper (BZIP) transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S006g000029</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P5D7"/>
    <dbReference type="STRING" id="1429867.A0A0G4P5D7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR ATF 4/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044:SF38">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="203"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="164"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="221"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL21489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="270" mass="29551" checksum="09AE073337F3A011" modified="2015-09-16" version="1">MHKLNPSGLEIQRCPPAVVRAQRQRSRSPFTGSNPPSTGTQERLQGPAEYSPWASLHPYTDNDFFSSLAPPLEGFSSAVPVCQSFDTLTHDPALWAEPDLSFADTDWNFVSVDHSTPYPPGYDGGDVPVMDLGYGSVSALNSLSDSGSIEHQHYVSASLAASSANSLDGHSHPSPISPFPAPVATSLSSPSTSQGDDTLGRVDSSRVEKRKLNTLAARRCRQRRVDRMKELEAELEKVRKERDDWRLRCSKLEGETDALKGLLTRKSKDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5P6</accession>
    <name>A0A0G4P5P6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S006g000162</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P5P6"/>
    <dbReference type="STRING" id="1429867.A0A0G4P5P6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="39"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL21622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="397" mass="45176" checksum="6333C95B44C55D92" modified="2015-09-16" version="1">MSKDCHAVSKRSRSKTASLRILLTTSSSQLSFIVFNDRYRIIAKLGYGAYSTVWLAWDERANEYASLKVSVRIDSNNAEASPVLNEINMLQRLKQFADKDHPGLDFTRLARDIFETESLASRHHCIAYKPQGNSVRTLQEVFPNAMIPKTLVKSLIHRLFFSVNWLHATCGVAHTDISPQNVLMEIDDDTSLQDIEDQESQDPSLPTTSTIYGAMPIVVYKSRPTMLTLSGHPILTDYGQMRLVEGCVNQDWWMSDLYRAPEVLLHLPWGFPADIWSIGVMTLELLEGKNLFDPIDHVHGQYVLPLALAQYIGYLGLPPMNIIQNSPLFSTYFDAQGNWVSELPVPEASLEDFVTTIPPGEEKDQFLRFIRKILTWDPEVRATSNQIILDEWLMRPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P612</accession>
    <name>A0A0G4P612_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Checkpoint protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S006g000277</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the HUS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P612"/>
    <dbReference type="STRING" id="1429867.A0A0G4P612"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044778">
        <property type="term" value="P:meiotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016580">
        <property type="entry name" value="HUS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007150">
        <property type="entry name" value="HUS1/Mec3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900:SF0">
        <property type="entry name" value="CHECKPOINT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900">
        <property type="entry name" value="MITOTIC AND DNA DAMAGE CHECKPOINT PROTEIN HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04005">
        <property type="entry name" value="Hus1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011312">
        <property type="entry name" value="Cell_cycle_HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR011312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL21737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="342" mass="37417" checksum="720548CD3306F43C" modified="2015-09-16" version="1">MRFRTQLRDSRTFSKLTASLSSLGKGTIFDDTTYELESNSDAINIEVNISVLNRALRSAWGSTHSQLRLTKKDKTPLLALTVLASEWTEGNMALATNNDADGFGDDANPEAPADTTGDRGPRERQTWITQEIPIKILHESAVEGLHEPHCPDPEVHIILPNLAQLKSISDRFTKLASTDSKSRQPGVIAPEAPGMHSVSFSGSGATAATALSTNSSPKLELSANMHGSLRLAIATDELRIASVWSDLVNPPLDPAQMTQEQMSQLPSELNRKREASEGFESGWAKVRIDGKDWSRVLSIGRLSPKVVACFVNEMALVLYVYLPSTRDGEESCLTYYINSFTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6E3</accession>
    <name>A0A0G4P6E3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S006g000427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P6E3"/>
    <dbReference type="STRING" id="1429867.A0A0G4P6E3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL21887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="169" mass="19449" checksum="46DE949D0DC0D232" modified="2015-09-16" version="1">MDDSTQQIRSHVMGQIRGILFGLPPDVVTGTMRILGDTPNSILDPNNYLESIRPFAWKVQDGLHQYDKNNTTRFLAVTIYPGKHSYFVVDLNNPDYDYQTAHECKTPVPVYVLRLSKRKPTIFRKPELDGQIAETLRAMHNNHGQDPLPLFDNYCDKNSYYGNPRSLQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6Y2</accession>
    <name>A0A0G4P6Y2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S006g000529</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P6Y2"/>
    <dbReference type="STRING" id="1429867.A0A0G4P6Y2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056002">
        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186:SF4">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195086" evidence="3">
        <location>
            <begin position="21"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7580" evidence="4">
        <location>
            <begin position="388"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="150"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL21989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="514" mass="57159" checksum="39198C52A9656608" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7L2</accession>
    <name>A0A0G4P7L2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S007g000240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P7L2"/>
    <dbReference type="STRING" id="1429867.A0A0G4P7L2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502:SF4">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="3">
        <location>
            <begin position="19"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL22259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="297" mass="32984" checksum="06908AA9DA82C132" modified="2015-09-16" version="1">MAESLGPDSAGLGNIRDGYPALASWIGRDPDGETLVFRRFRKLSARNLLHLQSQIIELEQKIEELDDEARGSADLDARQASRRWETLTQLAADPTRPERERLEKVTELSSKMKEYEEALLRQSRIAELSGPSNLVLSTYREYIEGNAWKSPYIPSVPIISGRAKDMLREADDLVALRRPADEDMLSKLLQDHWAFQTRKTTDPLDRTTIYKGQHITQIVAAISIIFAAVLLVVAIISLYIVNDPTTKLGLVVAYTFVFALSIALLTNARRVEIYGAAAAYAAVLVVFISGTIGAVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7W7</accession>
    <name>A0A0G4P7W7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Cof protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PCAMFM013_S007g000335</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>[protein]-with a C-terminal TM segment(out) + ATP + H2O = [protein]-with a C-terminal TM segment(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66168"/>
            <dbReference type="Rhea" id="RHEA-COMP:16963"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:90782"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4P7W7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140567">
        <property type="term" value="F:membrane protein dislocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07543">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000049">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000054">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000071">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057255">
        <property type="entry name" value="2TM_P5A-ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
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    </dbReference>
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        <property type="entry name" value="2TM_P5A-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
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        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="P5A-ATPase transmembrane helical hairpin" evidence="16">
        <location>
            <begin position="19"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="15">
        <location>
            <begin position="255"/>
            <end position="350"/>
        </location>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048588"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF23143"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL22354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1295" mass="144592" checksum="7F42D099104FB7B1" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P8F3</accession>
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        </recommendedName>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
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                <person name="Debuchy R."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <begin position="619"/>
            <end position="637"/>
        </location>
    </feature>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="718" mass="79642" checksum="3453524FE25AF872" modified="2015-09-16" version="1"> </sequence>
</entry>
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    <accession>A0A0G4P8I7</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL22631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="109" mass="11765" checksum="0F428051189E1CC6" modified="2015-09-16" version="1">MTDATFHTTIQDLRRAESKLSQLHGGNPPADSNVSRMKSIIDQNSNKPAQIDKVKANLPLPDQPPVASDWNSFDQRITSIGSGRLEFPPDNSGLRGNAPVGRSSSELGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P9C8</accession>
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        <submittedName>
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    </protein>
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        <lineage>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793141">
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195263" evidence="2">
        <location>
            <begin position="18"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL22912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="641" mass="68721" checksum="A5871EEF5AC09ED2" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PA06</accession>
    <name>A0A0G4PA06_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.205</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">2'-O-ribose RNA methyltransferase TRM7 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S009g000082</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine = 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42396"/>
            <dbReference type="Rhea" id="RHEA-COMP:10246"/>
            <dbReference type="Rhea" id="RHEA-COMP:10247"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74445"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.205"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.205" evidence="7"/>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PA06"/>
    <dbReference type="STRING" id="1429867.A0A0G4PA06"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106340">
        <property type="term" value="F:tRNA (guanosine(34)-2'-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002128">
        <property type="term" value="P:tRNA nucleoside ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000176">
        <property type="entry name" value="tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03162">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028590">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF12">
        <property type="entry name" value="TRNA (CYTIDINE(32)_GUANOSINE(34)-2'-O)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="9">
        <location>
            <begin position="21"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="85"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="317"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL23142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="433" mass="47625" checksum="A479E342F113E26E" modified="2015-09-16" version="1">MGKSSKDKRDAYYRLAKEQNWRARSAFKLIQIDERFDLFEHENPDNVTRVVDLCAAPGSWSQVLSRVLIKGESFGRRAWLEKKRKEQQGLEAAETTTTDDDKMDCDEPSPSSELKPRKNVKIVSIDLQPMAPLEGITTLKADITHPSTIPLLLRALDPEAYEQPSTPSDAPSSVTAAIRQPHPVDLVISDGAPDVTGLHDLDIYIQSQLLYAALNLAMGVLRPGGKFVAKIFRGRDVDILYAQLRTVFERVSVAKPRSSRASSLEAFVVCEGFIPPVSDSGVVGMAALKNPLFGGAAAPVTVSEDGNVGMEVREEIDQDTQARNTVAQPTAISSPAPNHSTEVRHLQTTTSQDQPQPQPQKLSNKFAVENRWIPAFIACGDLSAWDSDATYTLPPDYVNLDPIQPPTAPPYRRALELRKEKGGAYGKTKYGHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PA07</accession>
    <name>A0A0G4PA07_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S009g000049</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793142">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PA07"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="42"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL23109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="534" mass="57233" checksum="648708275B34F065" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PA08</accession>
    <name>A0A0G4PA08_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S009g000075</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PA08"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF149">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="69"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL23135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="546" mass="60983" checksum="C62DFAF55B905E66" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PA48</accession>
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        <submittedName>
            <fullName evidence="2">Xylose isomerase-like, TIM barrel domain</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PCAMFM013_S009g000115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793142">
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HYDROXYPYRUVATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="32"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL23175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="347" mass="38632" checksum="721CD93EF86C6ACD" modified="2015-09-16" version="1">MSIPHSSLQKIPLSYASCSIGCSPNDILPRRLQAIAEAGFSAIELSFPDILDYGAHISGNPIAPDNYPAIIPVAEQIRKLCEENGLKIMMLQPFSNFEGWVKGSVDREEAYARATGWMEIMNVVGTDLLQVGATDTPEPLIKKERNVIISDLQALSDILAKRNYRLAYENWCWSTHAPGWKEVWEIVKAVDRPNCGLCLDTFQTAGNEWGDPTTESGLIESVSRSELQKRFEASMDELARSIPSDKIYLLQISDAYKVSPPLEDKTIGGLRARGRWSHDYRPMPYDGGYLPIEDVAKAVLKTGFRGWFSMEIFDSGPQGTGKKYEMGSFAAKAMDSMQKFLKNCATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAA9</accession>
    <name>A0A0G4PAA9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S009g000154</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL23214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="274" mass="29977" checksum="97EA95D73B97325C" modified="2015-09-16" version="1">MRSPSVKPSAYPPVPFHLIRFLISLSSLVVGVILAVFTYHLHADGYKLPYSFLVLFVSSGLSLLNIILTSVIHCSCGLSTKLSISLNILLTILWALSLGLLSWSLSSTITTSCTTTYWGNSTGIAVCRSYKALFTFTVIGVVSYIAAVWLDVIVRRRQTRLGAYDPMGSHPGLDDSGAFDVKMDDHHSESTPALHDYDNVPPTMSGAHGQAHAQEHSVYEHNVQHAHAGEAQNYYDTAPGMSHRGAPRVRFGSVDEDGHQRPAQNTGYDPAMYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAD7</accession>
    <name>A0A0G4PAD7_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S009g000221</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PAD7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PAD7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06564">
        <property type="entry name" value="GH20_DspB_LnbB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052764">
        <property type="entry name" value="GH20_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43678:SF1">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43678">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
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        </source>
    </evidence>
    <sequence length="502" mass="56427" checksum="94EC3D8757061A56" modified="2015-09-16" version="1">MNHVLKLDTRMRLRLARSSQCRPWVQAHGKKLKTLETIRNASDTDLHSHATQTILTLRRVGQRLQHDLIPSTPGFQATLTDLQSVPSPPHSPQLHQVAEPGDQAGVPNSKSPQPLQPAGFTDHLSKETPSVPSPPHSPQPFQVAETTALSDQGVLSPQTPHFDSLQVSPPAAQLIPTRDSPGSAIRAKSKRALSPPDHVPDLLKRIKQSASWVWEAGQKLPSHLLSRKRSCDEDLRLEHIRRLEGDRTLGPEDKLLRLLALRSIALEFTNEQLDNEVCPTKLEEIYQHILSPSPSNINIFNYGNNNFFSKALSAGLKHMVFEKIISERLKENGLPSICNAISAIVGLHIDQFRRFRYDEMHRFADKLISDDIYVTILQSKIRLLDLVRDLSPWFSQVQNSYDLMFCYSPVSGMESGRQKFRRTDTSVPQDSVPSNMGFENVDIPNNGTESPNPEDCTEAEFAHLFYEQISNQPINISGIMDDIAQRSCFDFDRIAPLYNLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCF6</accession>
    <name>A0A0G4PCF6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cystathionine beta-lyase</fullName>
            <ecNumber evidence="3">4.4.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cysteine-S-conjugate beta-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCAMFM013_S010g000392</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L,L-cystathionine + H2O = L-homocysteine + pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13965"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:18121"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29256"/>
            <dbReference type="ChEBI" id="CHEBI:58717"/>
            <dbReference type="EC" id="4.4.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from L-cystathionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.13" evidence="3"/>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PCF6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PCF6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047804">
        <property type="term" value="F:cysteine-S-conjugate beta-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000013">
        <property type="entry name" value="Cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000009">
        <property type="entry name" value="Cystathionine gamma-synthase homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006238">
        <property type="entry name" value="Cys_b_lyase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01329">
        <property type="entry name" value="cysta_beta_ly_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF50">
        <property type="entry name" value="CYSTATHIONINE BETA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 13 14" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="13">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CRL23954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="437" mass="46923" checksum="BAAED29B9671C43F" modified="2015-09-16" version="1">MSASGSGIPNAASGSSSGVKKAFPQVDLSGNDLPPSPAPSSPHTGRRYNIATELVFTEGSDQYNASSVPIYQSATFKQTSNAGGGEYDYTRSGNPTRTHLERHLAKIMSAQRALVVSSGMAALDVITRLLRPGDEVVTGDDLYGGTNRLLKYLSTNGGIIVHHVDTTDPEKVQEVLSSKTTMVLLETPTNPLIKIVDIGKIATAAHEANPACIVSVDNTMMSPLLLNPLDFGADVVYESGTKYLSGHHDLMAGVIAVNDLQLGERLYFPINASGCGLSPFDSWLLLRGVKTLKVRMDQQQSNAQRIAEFLESHGFKVRYPGLRSHPQYELHNSMARGAGAVLSFETGDTSISERIVESAKIFAISVSFGCVNSLISMPCRMSHASIDAKTRAERAFPEDLIRLCIGIEDADDLIDDLQRALVQAGAVNVTMDGIEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PD74</accession>
    <name>A0A0G4PD74_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trimethylguanosine synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cap-specific guanine-N(2) methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S011g000231</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78479"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="Rhea" id="RHEA-COMP:19089"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:78480"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="Rhea" id="RHEA-COMP:19090"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:78508"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78471"/>
            <dbReference type="Rhea" id="RHEA-COMP:19085"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:78472"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78475"/>
            <dbReference type="Rhea" id="RHEA-COMP:19086"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78476"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PD74"/>
    <dbReference type="STRING" id="1429867.A0A0G4PD74"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071164">
        <property type="term" value="F:RNA cap trimethylguanosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000270">
        <property type="entry name" value="RNA methylase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019012">
        <property type="entry name" value="RNA_cap_Gua-N2-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741:SF32">
        <property type="entry name" value="TRIMETHYLGUANOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09445">
        <property type="entry name" value="Methyltransf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048740"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL24237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="236" mass="26620" checksum="5494AB0D64D6BF7E" modified="2015-09-16" version="1">MADEDAPPEVHHYSSLHEVPWDIQNYWAQRYRIFSKYDDGVWLTDDAWFGVTPEPVANVIASQIAESAPAGRKVLVDAFAGAGGNTIAFALTGKWKRIYAIEKNPAVLKCAKHNAKIYGVEDKITWFEGDCFEILKNQLKELAPYSVVFASPPWGGPGYRSDQVFNLKTMEPYSLQRLYDEYSVFSKHMVLYIPRTSDLKQIAKLVPDGDKATVMHYCMEGASKALCIFYGDFNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDH1</accession>
    <name>A0A0G4PDH1_PENC3</name>
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        <submittedName>
            <fullName evidence="18">Phosphatidylethanolamine N-methyltransferase, fungi</fullName>
        </submittedName>
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        <name evidence="18" type="ORF">PCAMFM013_S011g000379</name>
    </gene>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="protein sequence ID" value="CRL24385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004608">
        <property type="term" value="F:phosphatidylethanolamine N-methyltransferase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
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        <property type="entry name" value="Phosphatid-EA_MeTrfase_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138:SF0">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PEMT"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAM_CHO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 18" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
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            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
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            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="129"/>
            <end position="176"/>
        </location>
    </feature>
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            <begin position="139"/>
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        </location>
    </feature>
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        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00057332"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CRL24385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="778" mass="87365" checksum="D08C18B6C6E4CD77" modified="2015-09-16" version="1"> </sequence>
</entry>
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    <accession>A0A0G4PDV7</accession>
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        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793145">
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="20"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="72"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL24482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="167" mass="19390" checksum="48A734BAA8B53706" modified="2015-09-16" version="1">MFKVVNYAEQKNINPKRAEGTCRWAFRSSEYIRWWESNCNDLLWVSADLGCGKSVLARSIIDDYSETSRLNLFSQQSDLLTYAISTWEKNGGTLRQEVDELWRILMAATSAEISCKTICIFDAIDECRETDQRRLIDKLQAFHRQPSSSTEETCLKFLVTSRPYDHI</sequence>
</entry>
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    <accession>A0A0G4PEF0</accession>
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        <submittedName>
            <fullName evidence="4">NAD(P)-binding domain</fullName>
        </submittedName>
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        <name evidence="4" type="ORF">PCAMFM013_S012g000249</name>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333">
        <property type="entry name" value="2-HACID_DH_C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE NAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
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    </dbReference>
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        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="3">
        <location>
            <begin position="119"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="3">
        <location>
            <begin position="230"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL24639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="359" mass="39141" checksum="CF8C7D647A6E56D9" modified="2015-09-16" version="1">MGDAAFLPEHVLVIFYQSMPVELKEVIRHKFPDAEVTIYDAQPGVPVPSEVYQRATILATFANLPDIKDSKNLKLIHTFSAGVDHLLQNPILLETNIPITTSSGIHGPPIAEWTVMNWLVSSRKYVKGYEAQKSHSWDKSAYAPGLHDQVGKKVGILGYGSIGRQIARVSQALGMTVHAYTATPRPTPESRHDTGYIVPGTGDPDGSIPASWHHGTDREAIRSFLSIGLDHLVVSLPLTPQTTRLLGAEEFAILSDKSHHHTSKPYVTNISRGKVIDQKALVDALNSGVLGGAALDVTDPEPLPKDDPLWDAPNVQISPHVSALGVEYFPRSLDILALNLERIAQGEPLINSYTRGKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PEG0</accession>
    <name>A0A0G4PEG0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">PCAMFM013_S012g000322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL24712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="43" mass="4842" checksum="295DA0FCC3ABF706" modified="2015-09-16" version="1">MMINDQHSVHEIVEDLPGDRPVHECVDMAGWLAGWLAGDRQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PEG3</accession>
    <name>A0A0G4PEG3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S012g000274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793145">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PEG3"/>
    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195276" evidence="1">
        <location>
            <begin position="20"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL24664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="326" mass="35827" checksum="036DE5F811C07C89" modified="2015-09-16" version="1">MRLLLQLVLGICLAQKAFGYFPGSQGEPETDLEKRAYPIEAFPVVELWPNAKITYCFDSSDAKRYLRPLIPLAFKKWLNAGLNPAFKMVEGEDDYCANAHVGSVLTIRYNTDGILNTNQARVPNLPAISRLDPSPDIAMGDTLGNLAHELGHAWGLGHEHQRPSLWTPEFGGIGKTATLKFTCENMHDYASKKAEMEAQGENMDILCTDAVAARQNGFSALDMLAMGGGTESRFDPVDWKSIMIYGSTAGGKPTGNGKRAVTMTKADGSTFGYNSKPTPKDIKALHELYKDELPDPGTKSTKPFWKDGSKFTSMFKRKNKDDSCST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PEH3</accession>
    <name>A0A0G4PEH3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">PCAMFM013_S012g000337</name>
    </gene>
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        <lineage>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793145">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL24727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="43" mass="4741" checksum="6FD75E39AD3E519B" modified="2015-09-16" version="1">MLITASQEGSVAVARQLVEYVGRAVSFRRSGTNLEIKLQPYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PEP0</accession>
    <name>A0A0G4PEP0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxal phosphate-dependent enzyme, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S012g000331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PEP0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Trp-synth-beta_II"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PRK08206.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42937">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR42937:SF1">
        <property type="entry name" value="DIAMINOPROPIONATE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="1">
        <location>
            <begin position="41"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL24721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="423" mass="45597" checksum="E019FE0BDD2DDCC8" modified="2015-09-16" version="1">MQYTHISNPARLSQEAKSAAAVCMKNLSQWAIAVEEIRTWPEYSPQPLRTLPGFAQKVGVDQLFVKDESKRFGSHIGSFKALGAPYAVYMILAEEVYAKTGVRPSSAELRTSKYHDITRNVVVCVATDGNQGRGLAYGAQAFGCCCVNYIHDHVSDGRADQMKNLGAVVIRVDGEYEASVARAKEDARMNGWYFVSSTSWSDFDNDVPQHVMNAYMVVLDEALSMIPAVDKVTHVFVCGGVGSIAAAIFQGFYKHFYEIQKSSAASATVTMPRFVVVEPSEADCLLQSAKSREARESDGSLRTLMAGLACRTPSPAALKVLTWLASDFIAVPDSVAVDGMKALAYGEEGDIPVVCGESSAASMGIMLGSTTDPSLRENLGLNSSSQVVLFGLEGATDPDIYELLVGKSSQAVFEAQDGFVVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PEQ3</accession>
    <name>A0A0G4PEQ3_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SIMPL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S013g000055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL24813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PEQ3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.170">
        <property type="entry name" value="Protein of unknown function (DUF541), domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2970">
        <property type="entry name" value="Protein of unknown function (DUF541), domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052022">
        <property type="entry name" value="26kDa_periplasmic_antigen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007497">
        <property type="entry name" value="SIMPL/DUF541"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34387">
        <property type="entry name" value="SLR1258 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34387:SF2">
        <property type="entry name" value="SLR1258 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04402">
        <property type="entry name" value="SIMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL24813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="24968" checksum="3E6BD22DC96AD770" modified="2015-09-16" version="1">MAPLTIIVTGKSSVTHAPERGTLRFSVKGNGPEQDKIAKEVATSSTNLQKWMKSAFFHWNDDHPEAPLTQFSSTSIKTWTKSTDRDEQPVPNPHHASISFKAVFRDFTKLNQAIEELLVYPKVEIDGLDWSLTDETGSRLASDARKLALRDAIKQADDYSEVLERSVSVVEITDEGMSPYRATHKHMMAASFGGPAGEDPAPLDLTPQDIDVESQVNVTFKDLLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PF05</accession>
    <name>A0A0G4PF05_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PAN2-PAN3 deadenylation complex subunit PAN3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">PAB1P-dependent poly(A)-specific ribonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Poly(A)-nuclease deadenylation complex subunit 3</fullName>
            <shortName evidence="10">PAN deadenylation complex subunit 3</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PAN3</name>
        <name evidence="15" type="ORF">PCAMFM013_S013g000156</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein PAB1 (via PABC domain), conferring substrate specificity of the enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The N-terminal zinc finger binds to poly(A) RNA.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily. PAN3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL24913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PF05"/>
    <dbReference type="STRING" id="1429867.A0A0G4PF05"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3700:FF:000001">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex subunit PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000520">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex subunit PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.5160:FF:000002">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex subunit PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03181">
        <property type="entry name" value="PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030844">
        <property type="entry name" value="PAN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041332">
        <property type="entry name" value="Pan3_CK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272">
        <property type="entry name" value="DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272:SF11">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18101">
        <property type="entry name" value="Pan3_CK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25586">
        <property type="entry name" value="zf-CCCH_PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="277"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="49"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Knob domain" evidence="10">
        <location>
            <begin position="555"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="516"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="355"/>
            <end position="362"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="415"/>
            <end position="416"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CRL24913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="652" mass="72204" checksum="289099D3D7A4F52D" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PF35</accession>
    <name>A0A0G4PF35_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">O-methyltransferase, family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S013g000186</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL24943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PF35"/>
    <dbReference type="STRING" id="1429867.A0A0G4PF35"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF17">
        <property type="entry name" value="O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="269"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL24943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="433" mass="47852" checksum="D2C2D4BB5E3883D9" modified="2015-09-16" version="1">MPAENPKNTSVPVDLLIATHPNSAEAIPGLLEEVIKGVNSLATGTEEDRKDVLLKCRALARAVETPRETMVDHCWGQMGAIGAIGFGVDSGLWVLMAQNGDQPQKVTDLAGGLGVDPQLLGGLHITRSKVLANYILGRLMRHISAMGLLIEVGEDEYQPTNYTKALSLPQIGHGYLGLTASTGAGTLKFHEFSRKRGWVNPTDPWDTSLMYAYGTDKNIFPWVRDLGYGDHLNDYLGGYNLGRPLWMDPRVYPVEKRLIDGADSSPAAPFLVDIGGNVGHDLERFQSRYPNAPGKLILQDLPMMIDQIKELDPAIIRMGYDFHDEQPVKGARAYYIHSTLHNWSDDVCEIVLTRVKEAMKPGYSRLLLNENVIPNIGAHWETTGLDMMMLTLFSAEERTSAAWYDLIERAGLKIVKIWDGGKGVESVIECELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PFP3</accession>
    <name>A0A0G4PFP3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S014g000027</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PFP3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PFP3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF154">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_2G04560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL25131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="339" mass="38224" checksum="70F386327945C245" modified="2015-09-16" version="1">MTGIFTYRHFALGNIPALNGRVAVVTGGQAGIGKGKHKITTQLLLHDIEKVIIIARSEDKYITACEEWRHRKGISLENDTRAEFVKCDLGDIQDVKAAVEKIKQITDRIHILVCNAAISVQNECKHSPQKIERVFATNCVGHQVLTTSLLPLLKNGVTPSNDARIVVTSSSFHFWCQQLDLDLLFSLSRVKWPALYDGIWRYGRSKLGNILFAKELSRRLLDDEDPASKQIYVNSFFPGNIVTDQWLGWDSYFGKFVGWLIRAAGSWLGQSLEDGAATALYLATSQEVREQNHRAQYFIPIATLCAPSAISRDMKLARELWDWIDAQATETLGLDWQYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PG72</accession>
    <name>A0A0G4PG72_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S014g000198</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS30 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PG72"/>
    <dbReference type="STRING" id="1429867.A0A0G4PG72"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006846">
        <property type="entry name" value="Ribosomal_eS30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S30/UBIQUITIN-LIKE PROTEIN FUBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650:SF15">
        <property type="entry name" value="RIBOSOMAL PROTEIN S30, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04758">
        <property type="entry name" value="Ribosomal_S30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL25302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="62" mass="6907" checksum="BE5EA8EFA241DAFA" modified="2015-09-16" version="1">MGKVHGSLARAGKVKAATPKVEPQEKKKNPKGRAYKRILYTRRFVNVTMTGGKRKMNPNPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGQ8</accession>
    <name>A0A0G4PGQ8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S015g000117</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793148">
        <property type="protein sequence ID" value="CRL25531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PGQ8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PGQ8"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004631">
        <property type="term" value="F:phosphomevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005919">
        <property type="entry name" value="Pmev_kin_anim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF25">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04275">
        <property type="entry name" value="P-mevalo_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="310"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="902"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL25531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1155" mass="126153" checksum="5F74EBFA666A0BB5" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGS6</accession>
    <name>A0A0G4PGS6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S015g000160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793148">
        <property type="protein sequence ID" value="CRL25574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PGS6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PGS6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL25574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="649" mass="70059" checksum="5085219245C52B8A" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PH72</accession>
    <name>A0A0G4PH72_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Probable electron transfer flavoprotein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S015g000166</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </cofactor>
        <text evidence="7">Binds 1 AMP per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793148">
        <property type="protein sequence ID" value="CRL25580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PH72"/>
    <dbReference type="STRING" id="1429867.A0A0G4PH72"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000011">
        <property type="entry name" value="Electron transfer flavoprotein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN BETA-SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294:SF8">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="8">
        <location>
            <begin position="26"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00070315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL25580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="260" mass="28025" checksum="A34A79AB6A325B71" modified="2015-09-16" version="1">MSGLRILVPVKRVIDYAIKPRINKAQTGVETAGVKHSLNPFDELSIEEAVRLRERKGPIKVEDILALSAGGPKCPDVLRTAMAMGADRAFHIDVPEKGDGGPEPLTIAKMLQAVVKEQNVNLVLLGKQAIDGDQGQTGQMLAGLLGWPQATQASKVDIKDEAGTVEITHEVDGGVETLRAKLPMVITTDLRLNEPRYASLPNIMKAKKKPLEKKTLADLGVEDTRRLKTLKVTEPAPRKGGGKVEDVDGLVSKLKELGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PHN8</accession>
    <name>A0A0G4PHN8_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Iron-sulfur cluster assembly factor IBA57 homolog, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S016g000069</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GcvT family. CAF17/IBA57 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793149">
        <property type="protein sequence ID" value="CRL25788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PHN8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PHN8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057460">
        <property type="entry name" value="CAF17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GCV_T_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602:SF0">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25455">
        <property type="entry name" value="Beta-barrel_CAF17_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="CAF17 C-terminal" evidence="7">
        <location>
            <begin position="284"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="403"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="427"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00093447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL25788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="441" mass="48812" checksum="7ECFF3102BC39909" modified="2015-09-16" version="1">MMRPSPSVCSRCLVRRRLFSTTAQRAEQSQNAPFPPTAGYSRLTNRGLISITGIDSTTFLQGLMTQNMLVANDPNRSIRRTGAYTAFLNSQGRVLNDAFIYPLPGAEAQGVDSGWLVEVDKDQVPVLLKHLKKHKLRAKLKLRALEEGERTIWSSWKNHAEPQRWAAYSLESESPSPFSPTSEIAGCIDTRAPGFGSRIITPGSDGLRTYFPDEAQVAGAEVQLDSYTVRRILHGVAEGQAEVISGSALPLQCNMDMARGIDFRKGCYVGQELTIRTHHRGVTRKRLLPVQLYDLGQDGQSAPDTLTYDPSFQLSVPSGEADIVKAGVTTRRNRSAGTFLHGIGNIGLALCRLEVMTDVALMGEAPARPHDHHFKLSWAPEVEQPNEVGVRAFVPPWLRDFISGGKEEKPAPRNPEAEGERAREFVEQLEEEEEEAEARRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PI46</accession>
    <name>A0A0G4PI46_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S016g000142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793149">
        <property type="protein sequence ID" value="CRL25861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PI46"/>
    <dbReference type="STRING" id="1429867.A0A0G4PI46"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL25861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="583" mass="65595" checksum="6A44FC5905B3F3F2" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PIX7</accession>
    <name>A0A0G4PIX7_PENC3</name>
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        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S018g000038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PIX7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL26345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="235" mass="25124" checksum="FECB47BF2CFA564E" modified="2015-09-16" version="1">MQPAPGRSCNVPWSQELAVAEGGMVGLPNTQMAASVPCCQPLGDDIMLQSPRGWLASLRVQQADHADGVDGTIVPAPGRSCNVPWSQELACCCKWHGRPAEHADGSLCAMLPAPRRYNVGISQGLASVPAVCSAGRPCRWCWLYHRASSWEIDHIISPGPRSWRVVASGMVGLPNTQMAACVPCCQPLGDIMSESPRGWLVFLRVQQADHTDGVDGTIVPAPGRSYNVQVAWSAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJT5</accession>
    <name>A0A0G4PJT5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S019g000107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJT5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJT5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL26690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="234" mass="27161" checksum="BE26B8A5DDCA1E20" modified="2015-09-16" version="1">MPLSHHHRTFLTWEPEQAFGLWTLPTQLVAPNIEFIVEDFETEWQYKQNHFDFIHGRCLAGRCVADWPRFISRIFDHVKPGGYFESHESAVWAQSDDGSLKEDSALMEWQKAVNYAGEKLDRELNIYNKLKDWVIEAGFEDVKLSVYALPFSPWPRDPHLKTPGKYQAVQLQQAIDSYSLRLYTQVLGWRSEVAKIIMLSLSMSCGIRSCMLMFKRLPSMGESLFTHNICALIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJV4</accession>
    <name>A0A0G4PJV4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Long chronological lifespan protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S018g000126</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable component of the endoplasmic reticulum-associated degradation (ERAD) pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LCL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJV4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJV4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23996">
        <property type="entry name" value="LCL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034543">
        <property type="entry name" value="LCL2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38425">
        <property type="entry name" value="LONG CHRONOLOGICAL LIFESPAN PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38425:SF1">
        <property type="entry name" value="LONG CHRONOLOGICAL LIFESPAN PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195735" description="Long chronological lifespan protein 2" evidence="5">
        <location>
            <begin position="22"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL26433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="123" mass="13731" checksum="0B02E2FA492AF352" modified="2015-09-16" version="1">MLQSWRQALWALLLLVSVAQAQFNFFDQMFGGGEQQQRQQQRSQNAPSDSDRYQQMWNGAQCDHYLCPGTLACVHFPHHCPCPHPDVEEKVELGEGSAVCVSKGGFKAGEAARKIELARKGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKB2</accession>
    <name>A0A0G4PKB2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S019g000239</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKB2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PKB2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1170:FF:000006">
        <property type="entry name" value="NOL1/NOP2/Sun domain family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1170">
        <property type="entry name" value="Sun protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049561">
        <property type="entry name" value="NSUN5_7_fdxn-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048889">
        <property type="entry name" value="NSUN5_RCM1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF4">
        <property type="entry name" value="28S RRNA (CYTOSINE-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21148">
        <property type="entry name" value="NSUN5_fdxn-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21153">
        <property type="entry name" value="NSUN5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="7">
        <location>
            <begin position="135"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="357"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="472"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="534"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="472"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="566"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="436"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="252"/>
            <end position="258"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL26822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="585" mass="64202" checksum="E3BABBD9DC80636A" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKY0</accession>
    <name>A0A0G4PKY0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose reductase [NAD(P)H]</fullName>
            <ecNumber evidence="3">1.1.1.307</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S020g000178</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>xylitol + NAD(+) = D-xylose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>xylitol + NADP(+) = D-xylose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27445"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; D-xylose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.307" evidence="3"/>
    <dbReference type="EMBL" id="HG793153">
        <property type="protein sequence ID" value="CRL27019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKY0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PKY0"/>
    <dbReference type="UniPathway" id="UPA00810"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032866">
        <property type="term" value="F:D-xylose reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042843">
        <property type="term" value="P:D-xylose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd19115">
        <property type="entry name" value="AKR_AKR2D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044487">
        <property type="entry name" value="AKR2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="14">
        <location>
            <begin position="18"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="13">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CRL27019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="319" mass="35687" checksum="9B511CE892EC30D7" modified="2015-09-16" version="1">MVAPTVKLSNGHEMPIVGFGLWKVNNDTCADQIYNAIKAGYRLFDGACDYGNEVEAGQGVARAIKDGLVKREELFIVSKLWNSFHEADKVEPIARKQLADWGVDYFDLYIVHFPIALKYLDPSVRYPPSWTTAEGKIEFANAPIHETWGAMETLVDKKLARSIGVSNFSAQLLIDLLRYARVRPATLQIEHHPYLTQTRLVDYAQKEGITVTAYSSFGPLSFLELDLKHAKDTPLLFEHATITAIAEKHGRTPAQVLLRWSTQRNVAVIPKSNDPTRLAQNLTVTDFDLETSEIEAISALDKGLRFNDPIAYGLGIPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PL67</accession>
    <name>A0A0G4PL67_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin repeat-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S020g000055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793153">
        <property type="protein sequence ID" value="CRL26896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PL67"/>
    <dbReference type="STRING" id="1429867.A0A0G4PL67"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL26896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="365" mass="41519" checksum="8A9B9276297D1582" modified="2015-09-16" version="1">MLHDDKQMRGKRRNSTLVNEFLDAGASIASFELLPDEDENDFDDFEKQDSPLLRAAQNGHVGLLETMLSETNPSRACIPPQLRIVLHWAIEAGDQVIVELMVANGAPLGRSQFPSDNSTALSQALEFRYDESIIECILQTRWKPTALFPDPCVQATYYSDTSILQLLLRYGIRPKSTRILSHIARRGDTTSLRVLIDSGLDIVVYGHIALFIAIDLGHRAMVELLPEEGANPHLSSMDTNWSYYSTICHAVLYRQLDILKVLVAKRVRPDRQDLQLVIDLKFLEAVAILEDFSYEDVPKKTRREKWVQYWEDKCSGDPDSNGYSSLTAMDLSEIIFLLKEDRRRAKSVSPRVFSSTLMTRLESWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PLK1</accession>
    <name>A0A0G4PLK1_PENC3</name>
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        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S020g000190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793153">
        <property type="protein sequence ID" value="CRL27031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PLK1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="6"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL27031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="60" mass="6773" checksum="AAD6465AE26951EE" modified="2015-09-16" version="1">MLRFFATHGELHSPSSRLWVPPRASRDPLQMRNSEESSNANPRRRSFARVGVGPAREGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMC3</accession>
    <name>A0A0G4PMC3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S022g000169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793155">
        <property type="protein sequence ID" value="CRL27489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PMC3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL27489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="87" mass="10183" checksum="3473BAA9938F5FD5" modified="2015-09-16" version="1">MALVRDPYFWKRFSTAVHMDEESRAVVQGAQAKQDEASWLDRERRKSKRSIICGFVIFFGVVLVIVVSVVLWWLSKNNWLQPRPDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PME4</accession>
    <name>A0A0G4PME4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alkaline-phosphatase-like, core domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S023g000065</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793156">
        <property type="protein sequence ID" value="CRL27607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PME4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PME4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16025">
        <property type="entry name" value="PAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000044">
        <property type="entry name" value="Arylsulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.10:FF:000005">
        <property type="entry name" value="Arylsulfatase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050738">
        <property type="entry name" value="Sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693">
        <property type="entry name" value="ARYLSULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693:SF46">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G12940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="6"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL27607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="619" mass="69809" checksum="90D420F14AAB561D" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMF5</accession>
    <name>A0A0G4PMF5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S023g000088</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793156">
        <property type="protein sequence ID" value="CRL27630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PMF5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF91">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="40"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL27630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="472" mass="52902" checksum="9704124CD8458596" modified="2015-09-16" version="1">MSDISKTPVVETTAENREEFLASFSPQEKKHIRRKVDKRFLLLIGLMYMVKQIDVNNVSSIKVLQVGEKSNILTELNMSADQYNWVSSVYTIGYIIFETPSNLLLKKMTPRLWQTRIFFTWGIVLACQAAVQNRQGLLALRFLLAVLETGSYPGILTQLNSWYPSDEMATPVMWLLGISQCSSIVGSLLCYGISYMDGIRGLSAWRWVFIIEGIITILFSGVIFLVLPDYPKSPRSNKWLSPREQEFIEARLGDRAPKTADPAFSKKEILAALRSPIQWSFTFSQMLINLGMYALQWYLPTLTTSFGFTKLPANQLLNIPPAATGIIGVVLGSLILRHASFSKPVQLMVYNVGMIIAFILFFVVSATPGLYVACMLGTFFVNIYYIPFISWRSATMRGATGTAFAWGLQNSIGQLGGVIGPQLFQSKWAYNRYKNSFGIALAGVVAAIGTNLACWWWTNKQEKEELEASSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMP2</accession>
    <name>A0A0G4PMP2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S023g000178</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793156">
        <property type="protein sequence ID" value="CRL27720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PMP2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PMP2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF35">
        <property type="entry name" value="RTA1 DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL27720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="276" mass="30658" checksum="86D505D1BEAD1BF2" modified="2015-09-16" version="1">MSDYVLYNYTPSLAAAIICMILFIAIAFGHIFFVWKHKTKFFITFIIGGLFEAVGYGARAVNAHEAPNYSTMPYALQSLFVLLAPSLFAASIYMILGRIIRLLDGDSRSLIRATRLTKIFVLGDVLAFFIQSGGGGIMSSAKSASSLKLGEDVIIVGLIVQIIFFGFFVVVSVIFHKRMANDPTSAAMATSVDWHRYMLVLYFASALIMTRCVYRVIEYIQGSTGVLQSHEYFAYIFDAALMLLVTISFLVFHPSQIISGGHRKLDDMELMRGDMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNV7</accession>
    <name>A0A0G4PNV7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S024g000098</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793157">
        <property type="protein sequence ID" value="CRL27843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PNV7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.200">
        <property type="entry name" value="LURP1-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007612">
        <property type="entry name" value="LOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038595">
        <property type="entry name" value="LOR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04525">
        <property type="entry name" value="LOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL27843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="232" mass="26060" checksum="FF07EEDCDB0A1922" modified="2015-09-16" version="1">MSYTFYSNARLSHSYTSKPRKTLRSPDREIAFRNQYIARAKTTLVLRPFGSPHSAVAYKITEEDGTPQFTVTGRKYTDRSCREFRDESGLPLFELHRKWSWTNSWSVSLPGCDTATIATGAPRWTLGNTSFGNFDLSFENAAAFEGKRGDEKMLTLNIERHGNALALFDIVDGDRKVAEVRESIHHNEKLALMRGSRQGYRPAMDVIVMPGVDISLVATIAVIVSDWVFGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPG3</accession>
    <name>A0A0G4PPG3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polynucleotidyl transferase, ribonuclease H fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S025g000151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793158">
        <property type="protein sequence ID" value="CRL28093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PPG3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PPG3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL28093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="236" mass="26805" checksum="E5929FA76FDE5B47" modified="2015-09-16" version="1">MRKRKEERKHYKFCWEMGDGFHGFVFGFTGREAWNIANKILSLPVPKQVRKRLVYFCDASIRSLRGAAGIVWPDRYPSLKWQGKSIYYPLRTNDSATVELFAISCALRTAIEEIDEEHASVVANVPVDKEFFQSSMLRTESHLHSMSKEVFIFTDDINALRRIDGDLAYPPNGQMAGHVASISQYSRTLKRLGVHVELHLSPGHCKLPGNVAADAMAKRAQRQLVRETAISRPAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQ40</accession>
    <name>A0A0G4PQ40_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S026g000146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793159">
        <property type="protein sequence ID" value="CRL28281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQ40"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053221">
        <property type="entry name" value="Burnettramic_acid_biosynth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38887">
        <property type="entry name" value="CHROMOSOME 21, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38887:SF1">
        <property type="entry name" value="RAS MODIFICATION PROTEIN ERF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL28281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="415" mass="46762" checksum="43BBFFE019D3F0E6" modified="2015-09-16" version="1">MAQRQSYSSPPPYVVSSPGLHYDDSVSNNVHGWTYHGSGNTYQQPWVQYPNTEQSAPPLYPAQNQNNFVQQQHVAQRTRLCVIPQITKVFGGANMSPFARARSRELEAQTGLTQGDLLCFIDGLNEVFLANPALQATNKIGMLVGFVPLATAQIVGSGLQVAAGLGSAGVSAVRTKQYLKKANEVIFNPKGLLVRVVKTDKMLSLVGVRDSRVFSGEQYRLLVGGDGSQSQSPLETRMAALGDRVMSLTFDELAAPADEDNWMKKWGAYSAQKKEKKQLEKLQKEERRYKKADKKEKKYKKSRRNERKVDHAVADLQDDIEDIKKRMQSLDPRQPDKSKTGRELLRELRSLERKLVELEEDRADNLSQNSDKREKRQAKRDQKEAKKVNKLHWIVILPADASTGDEEHDLDSDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQT9</accession>
    <name>A0A0G4PQT9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">sterol 22-desaturase</fullName>
            <ecNumber evidence="7">1.14.19.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S030g000056</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.41" evidence="7"/>
    <dbReference type="EMBL" id="HG793163">
        <property type="protein sequence ID" value="CRL28769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQT9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PQT9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000249">
        <property type="term" value="F:C-22 sterol desaturase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000021">
        <property type="entry name" value="Cytochrome P450 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF228">
        <property type="entry name" value="C-22 STEROL DESATURASE ERG5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL28769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="537" mass="59925" checksum="1E0C8A132BDC355F" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PR99</accession>
    <name>A0A0G4PR99_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleotide-binding, alpha-beta plait</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S029g000062</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793162">
        <property type="protein sequence ID" value="CRL28646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PR99"/>
    <dbReference type="STRING" id="1429867.A0A0G4PR99"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12418">
        <property type="entry name" value="RRM_Aly_REF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025715">
        <property type="entry name" value="FoP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF82">
        <property type="entry name" value="THO COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13865">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01218">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="161"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="233"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="238"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL28646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="395" mass="43575" checksum="4F7CB0314E6A71FE" modified="2015-09-16" version="1">MDRSLDEIIAEDTVRLQRAMKPPKPTTDSLHCSGTLVAPQAVVVVLVVTTTPAVATSAMASERSALLSLCEFSSCSVPIVASPLDRWRLANEHATAKIWKRTLHGISSDLELTLSLFDNNSHTLQTVDWVHDKFDDDRSRPSRGGRRGRDGPDSDRSSTLTKVRVDNLHYDITETDLDDLFGRIGPVSELTVSYDRAGRSEGVAYITYARLKDAHTSIQEYDGANAKGQPIRLSLIPGRRDRNPLDSAHRPRSSLMDRVERPRDDRSMSPEDNADGRRRRGGGSRAHRSDVTKPAPDNIDRYVPGQRSHQRSPNRRGGGRRGGRDNRSQQTDGSNRRSNARPRKTQEELDQEMEDYWGGANNGGGEAAAPAQDTPQQTAPAPSAPAADDDIDMIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRF7</accession>
    <name>A0A0G4PRF7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S032g000021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793165">
        <property type="protein sequence ID" value="CRL28985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PRF7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL28985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="49" mass="5646" checksum="D85CDD1B4078B88D" modified="2015-09-16" version="1">MFPPYFHPPSIPLGVFGHLFIMNGFMAIFSPPHSVLQCLYDAFTLWSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PSA1</accession>
    <name>A0A0G4PSA1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S034g000085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793167">
        <property type="protein sequence ID" value="CRL29287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PSA1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL29287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="114" mass="12928" checksum="C1262DD9D0553A95" modified="2015-09-16" version="1">MSNPTERAAEDNYERENDPSPVTEDFTENSYAGEPKANLRDQVPVQEDEQSFDDPMQPPYSNSDQQLEGLEGDEREAINKSNIMRGDRLRHAKPRTTNKYNEGPDESDLPAGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PSL4</accession>
    <name>A0A0G4PSL4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S035g000060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793168">
        <property type="protein sequence ID" value="CRL29365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PSL4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL29365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="330" mass="37804" checksum="F12C2CF2D3C16721" modified="2015-09-16" version="1">MPVRTRSSCAGGLSQLPVSPIMGVPCTIRASQPSYQDQQSPQYRALMAIAELPDPDRSILGGFLIDARDPQEAGRYFLRVTGINGTPQSIPTKTILEVLSDWKYLVNWFRPIVETRLSAAAERLVYRRDRRCCLTQRRLKHSDMRFVHIVPPRVLMSPHLVEGGRLSDMLHAFLSKDLMESLRSLLSLNLQPMERVQNLWLLSESAFQLVEAGGVWFKIRSWDPRNSHRRQSYLIKTNPYRHRAQIHIPVPSTLLMDYTTEQTPIPHTDLFEINVQLGVLNTMMCRQLENTVINLKRYIPEPRGIPNEASKFQMCNSEGGGILVWRICDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PSL5</accession>
    <name>A0A0G4PSL5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S036g000023</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793169">
        <property type="protein sequence ID" value="CRL29439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PSL5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PSL5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF32">
        <property type="entry name" value="ARGININE METABOLISM REGULATION PROTEIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL29439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="663" mass="75194" checksum="8BEE261AEF1C26A5" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PTL2</accession>
    <name>A0A0G4PTL2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S036g000055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793169">
        <property type="protein sequence ID" value="CRL29471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PTL2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PTL2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056672">
        <property type="entry name" value="DUF7770"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24968">
        <property type="entry name" value="DUF7770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7770" evidence="1">
        <location>
            <begin position="33"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL29471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="180" mass="20033" checksum="00046A3D16BF294A" modified="2015-09-16" version="1">MEFGRKRNPYESSTPAYKLNIENDMRAISHASFVVHTLGKAGPTTSDNHWSIYLILADNSGSVRVNMAAEYGDTTGHLVWTGHSYALTTSALKNWDFVTTPGTTVASIAMLIYANGRDKYQMSGGGSGCRYWVYTITYDLSRVGCIAENCYSILWPHLQFQYHRNGGLKALNWVEGTFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PU71</accession>
    <name>A0A0G4PU71_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S042g000002</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPA43 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793175">
        <property type="protein sequence ID" value="CRL29943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PU71"/>
    <dbReference type="STRING" id="1429867.A0A0G4PU71"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04328">
        <property type="entry name" value="RNAP_I_Rpa43_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000004">
        <property type="entry name" value="RNA polymerase I subunit Rpa43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041901">
        <property type="entry name" value="RNAP_I_Rpa43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041178">
        <property type="entry name" value="RPA43_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17875">
        <property type="entry name" value="RPA43_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RPA43 OB" evidence="9">
        <location>
            <begin position="155"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="337"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="365"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="378"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL29943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="390" mass="42648" checksum="619AF14479FF36DB" modified="2015-09-16" version="1">MAIDAMEIDNLPVRTADAERKRKSKKDASSSASPSKKRKQAPSSKTPQTQDSNPESPFTLTTATLYLPLSPISISPTHALASLLAEHLSPLLLTYFPPLKGVVLAYSNASISSKPPAHPRASSDLNPQPLTLATTADEYGVLYVYLTATFLMFRPKRGQTLDGWVNVQSEGFLGAVVFNLFSVGVERKRLPSNWKWVPPGEEAETPALTDDDSGSDKDMADFDAEKECFKPASLSAEEIAINGEEEEDESAHTGYFQSVSGHRVSGSVRFRVVDVDVIPGSERDRGFLSIEGTMLSVEEEERLSASERQGQSLPPSFFPASQKVSGSIPVMNVPAASTVQELSTVDVHVDASPKKEKKEKKEKKEKKEKTEKTEKKEKKSKSSKSKSKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUE1</accession>
    <name>A0A0G4PUE1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="3 11">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 11">Lysyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S039g000081</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>tRNA(Lys) + L-lysine + ATP = L-lysyl-tRNA(Lys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="3 11"/>
    <dbReference type="EMBL" id="HG793172">
        <property type="protein sequence ID" value="CRL29772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PUE1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PUE1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000050">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000044">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034762">
        <property type="entry name" value="Lys-tRNA-ligase_II_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001756">
        <property type="entry name" value="PRK00484.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF9">
        <property type="entry name" value="LYSINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039101">
        <property type="entry name" value="LysRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="249"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="23"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CRL29772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="626" mass="71817" checksum="EB74E8A43DBAE74C" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUV0</accession>
    <name>A0A0G4PUV0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS10m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">37S ribosomal protein S10, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Mitochondrial ribosomal small subunit protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S044g000047</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793177">
        <property type="protein sequence ID" value="CRL30116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PUV0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PUV0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000003">
        <property type="entry name" value="30S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="8">
        <location>
            <begin position="138"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="13"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00078476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL30116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="293" mass="32403" checksum="B7F22056213D3C4B" modified="2015-09-16" version="1">MFSYTSRSLIGVGKRLRAPVPFRSLSSPTQPTPPEQEKTPAQDPTPTPTPVAPAEAAPVSPTPATPIATPAATPAATAPASTAPVAPTEAEQITESSVKEWSERLGAFGEDSRLPRSVQAIYLRPLRRKVEYGLPVCDLQLRSYSVRNVEFFTDFAIRAAYYLNLPVSGPVPLPRIVERWTVPRSNFVHKKSQENFERITLRRLIQIKDGNPQAVQAWLAFLRKHAFYGVGMKANVWEHDSLDAGKAMDASVAEVEEALRPELAQFGQRKDNSAPGTIFDTLNSERFAERKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PV66</accession>
    <name>A0A0G4PV66_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S050g000007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793183">
        <property type="protein sequence ID" value="CRL30360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PV66"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL30360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="303" mass="35137" checksum="04CCCBC0A84883C0" modified="2015-09-16" version="1">MPIFGPPRDFCERGSHISLPSTESDFHIPDDAERLTLSTRRRTTKRVERIQREIDRLTLTRKIEEIVRKIDTNRETTQYLLITNLSDTLRDYLLNKKIDGVRLTVDDHNILLRIMPSMQHECIISDFCILFADSMSVAGLLRRSDGWRGTGAAQRKGLHCAKEPDFSIVPKPHSLSTTVSPWPSFIIEIGLSESECHFHKDVKWWFDNSDHNTGLVLLFKVHREPFWVDVELWSRGLQINSQSDSLVLKQSLRVTRDEVTLLEGSSLDIHLDYEILMREAQPSRQKDIIITQQMLRFVCEEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVE8</accession>
    <name>A0A0G4PVE8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S052g000022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793185">
        <property type="protein sequence ID" value="CRL30465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PVE8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848:SF1">
        <property type="entry name" value="SUN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL30465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="441" mass="49715" checksum="040DE88D5078ECC4" modified="2015-09-16" version="1">MGRLHQADPPASSSHSLHSLDDAPPPYTDDPEPILAPVQHAQPIQPVQPPTSIRPLRLIDSAYVLPGGKDVKRTDKVSLTLEPSLSSNPEELYDVIRRQIKLPPRPLLYVHGTHTESGSDKKKEKNNTHTDFKFKLDLAETMLTGWEGGPMHANWREIEILTDEDLKPAYRGGILRSRTYKPPKSHAAISLTGDTDALLARHDTDEGHNTSPEPKNLRMWCERFCRDPASVKSFTLHRELAGFDSNAMRNVLSSHIRELNYRGSIGFNLVIAQRSVTIYSPHWINRLRTNRYVWWAVVLLQLWIIAWPVIFFMEKRYELVHARWNASLIPESDSALAKCYAFGRDESSLGEYWAPAVKQAAWTRRRGEGDVLTRMDADRLQGYSTQQLLGLRGAASDNELERRGRVNSGEGGFVDNVVGLVRGIGEASQDWRFSAGWGANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PWV0</accession>
    <name>A0A0G4PWV0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger, C2H2-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S065g000007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793198">
        <property type="protein sequence ID" value="CRL30957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PWV0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PWV0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535:SF2">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535">
        <property type="entry name" value="FLUG DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="123" mass="13735" checksum="DD5E3BCB01FFE8C1" modified="2015-09-16" version="1">MLPTAPLPKRQKPIPLDESGDTFSEAIASVCVKFLGERPTICFMCLSNTRLPERERLKMYKNPGSLSRHFVNKHIKPFPNDMHCECNICGEKLMSKPGLLNHAQRMHGTVSCLPLPALGLPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PWW1</accession>
    <name>A0A0G4PWW1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S061g000024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793194">
        <property type="protein sequence ID" value="CRL30850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PWW1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="121" mass="12826" checksum="5EFA9FA6373DA2D6" modified="2015-09-16" version="1">MRALELMHFVVTAPYQPLRNIWIEAFNHVRGVEACGTEGNASAAWIAVKESGLVSFFNYEGSTSTCAFDNGLKHGSRCDASDSKSSTKSLSALTTPKSSSTVSGSSSTTLHTSPSPSCFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PXC5</accession>
    <name>A0A0G4PXC5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S069g000001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="79"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="424" mass="47774" checksum="DE4E9FD55C26F8B8" modified="2015-09-16" version="1">MADNLPTMFTVTEHVIDAQYIREYPNATVSQDSPLKLVVKKYTPTDNPNPQPGDVTIELYEPLWEEILVQSKQQGFRMGSIWIADVANLGASGVVNEELLGDDPSWFDHPRDILHMINHFRHEMPRPIIGVGHSMGATQLALLSLIHPRLFTSLVLIEPPFNQSLLAVQTFALLSIKRRDTWASRSEATKSAARSYARWDPRVLRRWNEHGYRSLLTTIYPQTDGEVKSTNGPVTLTGSKYQEAMLFLRPNFLGHTTSVLADSTKTPLHDPLVYPDIIDPPNPSMPFYRSEAIIALKIVKHIRPPVFYLFGGESPVSTPEEQALMLERTGAGFGGSGGVKHSQVKTATILDCGHMVPFENVEESASLVGTWVGQSVQRWQKDELRVHQKWSNQSTSEVLTATAKWRPMLEELFKSQGRTERWKI</sequence>
</entry>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Dupont J."/>
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                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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            <end position="91"/>
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            <end position="288"/>
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            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL31194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="355" mass="37708" checksum="3D512F1B69122FD6" modified="2015-09-16" version="1">MLGGNIVSAPATYTQGSSLSSQQFKIFSGPATSPETHVLWGEEWRHLTSNILPSTALPFGPTDQRLDKVSSLPSPHSETATNGFVSDWSDTGSTETIKPTTTYAEADNELGSSGLVYQDSQKFSGTCCLNSLVVTDTVESKIGIQSMLQPTGLGIDDSHDATEGSGVVLYPDKSYNLPVASLLITPTSNWVSESTYAHAPSAYSSQATSQGMQAGEPQAKAKNVGIHVTRNPNISSNCVRLSHELMCSQTVQERPEASDGGLSKPPPVTITSFTHPKSTGPDTTTETDSIVEKPTMDKTRASRTAPAHVLGLVLGCVFGPRRNTDSTPLPKADSASAKYLRVSESMEVSRFSAYS</sequence>
</entry>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
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                <person name="Bensimon A."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL31412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="78" mass="8865" checksum="6B1638A5E9912E06" modified="2015-09-16" version="1">MYECGPELAVRLPGEWPSIHERQGLKVQRWILDHKRHRVAVIVRMRNDSSNSCGHDIVCMNDITRIAPEAQGSPTTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PZC1</accession>
    <name>A0A0G4PZC1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S4Jg000044</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
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                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
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    <dbReference type="STRING" id="1429867.A0A0G4PZC1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:cytosol"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051059">
        <property type="term" value="F:NF-kappaB binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071356">
        <property type="term" value="P:cellular response to tumor necrosis factor"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051070">
        <property type="entry name" value="NF-kappa-B_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680:SF3">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR CACTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
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    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="204"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="237"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="272"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
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        <location>
            <begin position="115"/>
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        </location>
    </feature>
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        <location>
            <begin position="32"/>
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        </location>
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        </location>
    </feature>
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            <begin position="64"/>
            <end position="77"/>
        </location>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL31522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="303" mass="32964" checksum="A04CB07FB7773935" modified="2015-09-16" version="1">MAMPSSKFPDLPGSGYPQTPIRPARRVLVQMSKEDQRRERNRQAQRKHRESVKQQLEKYDRLRQSLQHPGNDTNPSTHLADLRSGQQKFCPLPSAGVNPCMHPQSILPSLFPEVEVDQPIDPPSTEPNDPLSHRFLPSAGYAKRVYSSPSTVHDGDSSTVSSRVEEHFSVAVPPSDTSFPLDPNLLSPSSEIESNARACNGQAFGRTLLHQGVIMNSEDIVSVLLAHVADVKAQDNDGRTPLHVAAALGYARVGRLLLMHGAAATVSMADGHGLTAMHLAVQNGHASMVEALVECGADINLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NTM0</accession>
    <name>A0A0G4NTM0_PENC3</name>
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        <submittedName>
            <fullName evidence="7">Fungal transcriptional regulatory protein, N-terminal</fullName>
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    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S001g000405</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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    </evidence>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090:SF1">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="3">
        <location>
            <begin position="110"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL17730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="356" mass="39632" checksum="33CCC1887264B482" modified="2015-09-16" version="1">MIPLQTFRASLSRRCFTPTTTIRKYASQTPGNPMLEVFNRKVKHLQKDRAARNVEESRKVDYLKDEVAMRLCERLLDIKRDFPNVLDLGANSCNIARALTSPNIDSVMPEGTITPPLSKKISKLTCVETSRALLHRDEEDPFNKEINIQRDVIPDLETLPYAPNSFDAVLSSLSIHWINDLPALLEQVNTILKPDAPFIAAMFGGDTLYELRGSLQLADMERRGGVSPHVSPLADVKDIGSLLGRTGFKMLTVDVEDIVVEFPDTFALMQDLQAMGEGNAIMNRDSAPLSRDVLLANEAIYRSLHMEEGARGIPATFRLIYMIGWKEGEGQSQPLQRGSGDINLKDVLEGGDLDKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NVC8</accession>
    <name>A0A0G4NVC8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Peptidase A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S001g000998</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL18038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NVC8"/>
    <dbReference type="STRING" id="1429867.A0A0G4NVC8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005194813" evidence="9">
        <location>
            <begin position="19"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="10">
        <location>
            <begin position="63"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL18038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="494" mass="51610" checksum="17B3DC0CE089E402" modified="2015-09-16" version="1">MWGISILSIALALPCANAITLHKRDDPAVFSLPIARSDRPEPLQKRSSKVASTALYNVQNMYYMVNITVGTPAQNLSLSLDIGSSDIWVNIPNSTYCKGDDDPCSSTGLFNLEDSSTFKMLDYEMNATYASGFLAAGHYATDTLVIGDAKVKDMEFAVAEKSLNPHGILGIGYAANTDAATNLGNEYANLPEELVKSGAIKSTAYSLWLNKFDGTGNLLFGGVNKARYQGELQTVPVVPMYGKYYSLAIALTDISVKTTKGSKDFTTGLPLAVTLDNGSPFIVLPKEVVDPIYKEVGGGYSSTVGAGYIPCDMYTADYNVTFSFSGAKVVIPISNLMWENTSYDGFPKGTCLFGISYGEPGVSLMGDTFLRSAYVVYDLANNEISLANTDYDGGDDDIHEIGTGTDAVPGATLMPSAVTSATGLEPSATIAASGSSGSEPTGTTVFVTGTSTVTGAANSGGASSTSSSGMAALPTSNPNHLLPGLLGAGLLLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NVD0</accession>
    <name>A0A0G4NVD0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phox-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S001g001016</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL18056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NVD0"/>
    <dbReference type="STRING" id="1429867.A0A0G4NVD0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06867">
        <property type="entry name" value="PX_SNX41_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044106">
        <property type="entry name" value="PX_Snx41/Atg20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051079">
        <property type="entry name" value="Sorting_Nexin_Autophagy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979:SF2">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="10">
        <location>
            <begin position="94"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="221"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="446"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="448"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL18056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="632" mass="69843" checksum="FFB116322D83659C" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NVN8</accession>
    <name>A0A0G4NVN8_PENC3</name>
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        <submittedName>
            <fullName evidence="3">WW domain binding protein 11</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">PCAMFM013_S002g000005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Wbp11/ELF5/Saf1_N"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="6"/>
            <end position="83"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
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            <begin position="86"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL18135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="293" mass="33135" checksum="4705489CD5F908B1" modified="2015-09-16" version="1">MAKDKERSVNPAAAQRKLDKQKELKKGKSEALARRNEKLARRNPDRIQRQINSFKEAEESGQKLRPRDKELLEALEKDLRGVLKAREALGDKAPRFDHGSRGGHQGDGARRGGGDGVLGKRRRGSDETRMPRDSDSSDTDEDVRRIPMPRDTPPPIPRQHQRRRDVNVPSEQNAERSGPHPLPSRPTAAPVARTVYEAKPQIRDLRQEATKKFVPAAVRMKQQSIKGQGKLLEPEEMDKLEKAGYNAGPAPEAQAGDSPQEDWMLTLEEEERRFNQESKSVQIEEVEDEEAWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NW20</accession>
    <name>A0A0G4NW20_PENC3</name>
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        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF11">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="8"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL18267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="280" mass="30035" checksum="D1379F81E98A90B7" modified="2015-09-16" version="1">MVSKSFAVVLCHGSYHTPAPYQALVNGLTAKGIETYCPQRPTCDLSQLNVGNPNNPDFDRKAPPGGYPLPADDAAEIGLLLDKLIAQGKSVLLAGHSSGGWVAAEAAQSSRQAPVRAKEGQTGGVIGIFFIGAFIVPQGQSVHSFFQPPDGKVVTPPFMRFHKHGVNGLGTMVDAEQYLFNDLDVATAKKWTSTLTAAPVMNSPLTHNPYDVLPCAYLVLEKDRTLPKEYQEGMAASQSKPFTIYHAPCGHSPHLSWTNELVAKIEEFGTQVLAESSPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWV7</accession>
    <name>A0A0G4NWV7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S002g000458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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            <end position="93"/>
        </location>
    </feature>
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        <location>
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            <end position="322"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="515"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="571"/>
        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL18588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="620" mass="68506" checksum="152B392246164B4B" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXR9</accession>
    <name>A0A0G4NXR9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S002g000757</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-glutamate + NADP(+) + H2O = 2-oxoglutarate + NH4(+) + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11612"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.4.1.4"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 10">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4NXR9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004354">
        <property type="term" value="F:glutamate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05313">
        <property type="entry name" value="NAD_bind_2_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.285.10:FF:000001">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.285.10:FF:000003">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000002">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000030">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.285.10">
        <property type="entry name" value="Glutamate Dehydrogenase, chain A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
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        <property type="entry name" value="PRK09414.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="191"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="8">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="8">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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    <feature type="binding site" evidence="8">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="9">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048584"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
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        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL18887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="461" mass="49760" checksum="EAC05D54B8F41E4F" modified="2015-09-16" version="1">MMQNLPFEPEFEQAYKELASTLENSTLFEKKPEYRKALQVVSVPERIIQFRVVWEDDKGQVQINRGFRVQFNSALGPYKGGLRFHPTVNLSILKFLGFEQIFKNALTGLNMGGGKGGSDFDPKGKTDNEIRRFCVSFMTELCKHIGADTDVPAGDIGVTGREVGFMFGQYKKIRNQWEGVLTGKGGSWGGSLIRPEATGYGVVYYVEHMIKHASGGKDSFAGKRVAISGSGNVAQYAALKVIELGGSVISLSDSQGALVINGEEGSFTVEEINTIAEIKVERKQIAEIATQAAFSSKFKYIAGARPWTNIAGRIDVALPSATQNEVSGDEAKALIAAGCKFIAEGSNMGSTQEAIDVFEAHRDANPGAAAIWYAPGKAANAGGVAVSGLEMAQNSARVNWSREEVDSRLKKIMEDCFNNGLATAKEYVTPAEGVLPSLVAGSNIAGFTKVAEAMKEHGDWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NY06</accession>
    <name>A0A0G4NY06_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Basic-leucine zipper (BZIP) transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S002g000847</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="bZIP_YAP"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR052635">
        <property type="entry name" value="Sec_Metab_Biosynth_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607:SF1">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607">
        <property type="entry name" value="XANTHOCILLIN BIOSYNTHESIS CLUSTER TRANSCRIPTION FACTOR XANC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL18977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="284" mass="32028" checksum="96AC6F1EB7A24412" modified="2015-09-16" version="1">MNRSPSYDGRSGSRGSHSNSSAFSPNANPNEDWTKISDLAERRRIQNRIAQRNYRKKLKRRLEDLERRAATSASPEQSHAEPVSPKPSPKTRTKQRSSKTTDVKPHSQSDRSASYDYCSPEDRQTMFAQQCTRQLSASPPPVFSYPSMSSYDTYRQSVYSQSPIYHAAPSTYSEIAYQTEYGEPAPSLVPVLPSMQARKLAYDEDMISPFSMSYATMAGIDLCQQQAQAQSHSQHQPSALPMPTLAYYEDRPSTSPEASIFTFPLTPESAPCSPRMHYEYDLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NY38</accession>
    <name>A0A0G4NY38_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S002g000868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NY38"/>
    <dbReference type="STRING" id="1429867.A0A0G4NY38"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.230">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL18998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="348" mass="38144" checksum="BFB86102B5878E33" modified="2015-09-16" version="1">MGDALCGPSNALQNFQKHTSVDRTLQQDRLTSRQSPVQGFRSQNPQEGILDPEFAAFEGNLAGPALPNLQHPAHFGAPSHHAAIHHPAAHSAGNAGWAADFQNLQISGPSHPVAQLQRPSMAPASANGGWHTEFMTQQRGPMSQAQQTPQMHGAYQPSFAPGYQMYGSSMNQMQAPQGMQTEQQLHAQQFDESAFEAAFDQARADMELQAVDVAQQDTQKDLQETNEVEITEPVAQEQIRLGSDLIPQSDKQDPETQSRDADDLARTAGQLLDSVRNEQSQKFQQSNFLALMRRIRDREVEVAGDDFRETAQSLHPGGRYYPGPPHTNPPGSDMPSSSKEPNNPVGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYK9</accession>
    <name>A0A0G4NYK9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="5">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S002g001011</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = (6R)-5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="5"/>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL19141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NYK9"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="163" mass="18293" checksum="5CCE2CB05A9047D4" modified="2015-09-16" version="1">MAFQAAKRDLRKRMRSTLQTSTATTNFLSLPEYQNAKSIAVYLSMPSGELSTTGIVKDALQRGKNVYIPYIHTQDKTSIMDMFALGSMSEFESLQLDKWGIPSLLSTQIPGRSNGLTQGLDLIVMPGMAFDRGFRRLGHGKGYYDHFLTRYSTSIHKMPFLGK</sequence>
</entry>
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    <accession>A0A0G4P0U7</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="266" mass="28724" checksum="5A33341CF8418564" modified="2015-09-16" version="1">MLYPTAVTTRVDNPRLRLLNMLREGSKPIMTFMGLPSFRTAQVVALCGVDAIIIDCEHGHINDDSMHTATAAIAAQGVSPVIRIRMTHPDLIKRALDAGAHGIVVPQINTAEEARSVVSYAKFPPQGLRGQGSPFPGIAHDTSIPTYMKTANETIITCLQIETKEGLANVDSICAVPGVDMIFIGPNDLALSLLGYVPAKGDEPEFVQAINKIVGAARRHGKWVSRLSNDGNAGKDHLAVFDTVALSYDVRAIQNWYKAELKTARS</sequence>
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        <submittedName>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="100"/>
            <end position="389"/>
        </location>
    </feature>
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        <location>
            <begin position="610"/>
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    </feature>
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        <location>
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            <end position="733"/>
        </location>
    </feature>
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        <location>
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            <end position="769"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL19955.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1204" mass="134209" checksum="4957057CEB03EFBD" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P1B9</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P1B9"/>
    <dbReference type="STRING" id="1429867.A0A0G4P1B9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510:SF1">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="50"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL20117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="406" mass="44831" checksum="20FBACE16A8AAEFD" modified="2015-09-16" version="1">MVKIEAFTVEQWMGKYETTATYNIAETCCAPISINDLKELSDDKDTNLWAQLQSSTIGYGVVPGSGRLRGNLATLYSADAPNLLPKENVLITGGAILANFLLLYTLIGPGDHVICHYPTYQQLYSVPVSLGAEVSLWHSKENDGWQLDIEDLKRLIRPNTKMIIINNPQNPTGAVVPRETLQSLVDIARKSAITLLSDEVYRPLFQDTSAAPPSLLSFGYEQTIVTGSVSKAFSLAGLRIGWIASLDKSIIDACAASRDYTTITVGLIDDTIASFALAPECVHNLLKRNLGLARTNLEILERFINSHRWACDWVKPSAGTTAFVRFKKRGEPVDDSILCEKLLERTGVMVVPGRFCFGRDQDFRGYVRMGYVCQTKTLEIGLERLSQFLNDGYGDVPVSKKVLVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P1J6</accession>
    <name>A0A0G4P1J6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Mediator complex subunit 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S004g000130</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SRB8-11 complex, which itself associates with the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 12 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4P1J6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057344">
        <property type="entry name" value="ARM_SRB8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019035">
        <property type="entry name" value="Mediator_Med12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25326">
        <property type="entry name" value="ARM_SRB8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09497">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01281">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med12" evidence="13">
        <location>
            <begin position="273"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1470"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1470"/>
            <end position="1486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CRL20190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1571" mass="172864" checksum="897723D1F983DEF6" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2A0</accession>
    <name>A0A0G4P2A0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L22/L17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S004g000313</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P2A0"/>
    <dbReference type="STRING" id="1429867.A0A0G4P2A0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.10:FF:000017">
        <property type="entry name" value="54S ribosomal protein L22, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047867">
        <property type="entry name" value="Ribosomal_uL22_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="CHLOROPLAST 50S RIBOSOMAL PROTEIN L22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501:SF10">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL22M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="54"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL20373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="332" mass="37507" checksum="D81829F1BAC4DEF4" modified="2015-09-16" version="1">MVYPSGQLVRTAARTVSFVPRRTLTSTAIRYALNDGESKKPTGLFSSLKNMFSGGSSQKHKVAHRPSAPKKEDGLGTSIFGSDFTAPTTGPMPSRPTGEQQKESISGKLEDRDLSRLQVGLGPDPKAQLRWERKMAVREVRKRGRVPTKVQIKRTERESLSKSHWIKTSLKKLGPLARQIAGKNIDEAILQMRFSNKKAAKDVLEHLEHAKNVAIVRAGMGLGASNTEPSKPITVILKTGERQKIANPTDIYVQEAWVNRGPYGYEMDHRARGQINRMRPPTTSLSVLLKEEKTRIREWEDREAKAQRERRSQLWTQLPDRKVSAQNQYYSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3X2</accession>
    <name>A0A0G4P3X2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD40/YVTN repeat-like-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S005g000122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL20958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P3X2"/>
    <dbReference type="STRING" id="1429867.A0A0G4P3X2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF1">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195014" evidence="2">
        <location>
            <begin position="24"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL20958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="394" mass="42199" checksum="D00FDDAE26423B84" modified="2015-09-16" version="1">MMRPILLSTILFGAASMATKLYAASYSGTVTTLSPRRANGSYDLSIVAQTKDCGASPSWLTLDNEHDLMLCLNEGLGASNSSLTSFRVNANGSLTTLDVLETVSGPVMSALYTIPGQPRRRFVAVAHYSGSAITAYTLDSTSGHLNQTQTFTYELAAPGPVPDRQDAPHPHGAIVDPTGRFVLVPDLGMDQIHIFKISPSDGLLQPQKPLLVKPGSGPRHAVFWTPKTNVTSTDDTFLYLVSELENTLTAFKAHYTRNGLTFVKVHEESTYGGEAIPSGSTAAAIHISPENDRIVVSNRGDATFGKNGDSFAVFTCITGRGNHAKDFSFVGLYPTYGSAPREFDINGQNGVISVALQDSHEVALVQWDKQTRSPGKLLAKKSLDGKIPAAIWGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P4T2</accession>
    <name>A0A0G4P4T2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-directed DNA polymerase, family B, conserved site</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S005g000477</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P4T2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL21313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="243" mass="27627" checksum="D2D6ABC359C1A93D" modified="2015-09-16" version="1">MKAFRFLSKGTRYDQLEQGKDGDLRSPAPPPRSIFSSPFGLALHALIAVFWVSASWYLMYRDICRPGLHALEFGPVASSIQYQDIVFKMSGMGTREHPVTEYEGPPTPENNVKWFELLDEPASDTDSTPLIQLEVFHQLHCLNSLRRLIYNTSTFTKGVNAEMHMDHCIDYLRQSIMCHSDVTPLVHIPRPGGSRNNGTAWIPNFAVKHTCRDFWKIHEWAAQYNTSGWTIEGYPNQGLALAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P4V5</accession>
    <name>A0A0G4P4V5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial substrate carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S005g000503</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P4V5"/>
    <dbReference type="STRING" id="1429867.A0A0G4P4V5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000184">
        <property type="entry name" value="Mitochondrial carrier protein, putative (AFU_orthologue AFUA_6G12900)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF10">
        <property type="entry name" value="SLC (SOLUTE CARRIER) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="94"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="188"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL21339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="308" mass="33403" checksum="4E520E360E2A0E75" modified="2015-09-16" version="1">MAADFWAGYISGAIGIIIGNPLDVIKVQLQAGNAHADVSSAQLSRFERASTLVRGAAAPILGYGALNAILFVAYNRSLTALDGSVTDPTNPVGVSAYKIWLAGAAGGLASWSISSPTEFIKCRAQLDRRPEVSSWAVAKDIFRTRGWRGLYFGGGITSARDSIGYGFYFWSYELCKRFMTSDDDGSHQAALKILLCGGIAGVVTWGSVFPLDMIKTRLQAQTIADHSPGTIESQSLLRPQRQTLNSFQIAKETYRAEGIKAFYRGLGVCSVRAFIVNAVQWAAYEWLMKSFNHSWGAQVKTQEPIAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P4Y6</accession>
    <name>A0A0G4P4Y6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclin-like F-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S005g000533</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
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            </authorList>
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        </source>
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        </location>
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        </location>
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            <end position="544"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="668" mass="74592" checksum="9959F0B124B66050" modified="2015-09-16" version="1"> </sequence>
</entry>
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    <accession>A0A0G4P572</accession>
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        <submittedName>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL21455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="104" mass="10863" checksum="263334AA5C4D2573" modified="2015-09-16" version="1">MLNRTSLRKSVSPRPSVEGLSMSVSAAEQGGLTLVPPVDEVNRSELTGNGAAGEADKPNAVFQGCLVDPSASIDEPQVLHQPVQDHISPAHYIAGPLYCGSLNN</sequence>
</entry>
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    <accession>A0A0G4P5M3</accession>
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    </gene>
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        <lineage>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Silar P."/>
                <person name="Lacoste S."/>
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                <person name="Bensimon A."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008397">
        <property type="entry name" value="Alginate_lyase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
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        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DBAG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alginate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195261" evidence="7">
        <location>
            <begin position="18"/>
            <end position="1024"/>
        </location>
    </feature>
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        <location>
            <begin position="81"/>
            <end position="303"/>
        </location>
    </feature>
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        <location>
            <begin position="402"/>
            <end position="436"/>
        </location>
    </feature>
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            <begin position="464"/>
            <end position="507"/>
        </location>
    </feature>
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            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
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            <begin position="496"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF05426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL21579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1024" mass="112783" checksum="5A771E09CE146DC5" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P636</accession>
    <name>A0A0G4P636_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="11 13">3.2.1.106</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Glucosidase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PCAMFM013_S006g000303</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="14">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="11 13"/>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P636"/>
    <dbReference type="STRING" id="1429867.A0A0G4P636"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
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</entry>
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                <person name="Renault P."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    <dbReference type="PANTHER" id="PTHR45588">
        <property type="entry name" value="TPR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45588:SF1">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL22556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="553" mass="61412" checksum="CDA2182F0718FDA7" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P8E4</accession>
    <name>A0A0G4P8E4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S008g000020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P8E4"/>
    <dbReference type="STRING" id="1429867.A0A0G4P8E4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22584">
        <property type="entry name" value="Rcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="159"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL22591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="440" mass="50658" checksum="0B782C0FDD3283AB" modified="2015-09-16" version="1">MEQDQDKRLILKLLLEDLDDLENRQKGKQAAGKETDLEIAIACLRQDIRTTQISIEDEILAISTTTAIVTDQKILASLQHQERVANQDRQLALSLDNGTRTNNHIPNPEMITEITSPDDDDDAVSIVMGDLMGRMTLSDKASNNEEGPSRMHPPRTNNLMRECVSCFTKVNDIMFKGSCGHEFCRDCTRQMFLGAIKDEELYPPRCCANVIPPGVALRILSYDELRRFSERALEWTAKDRLYCAEPTCSKFIPPFAIQDEHGTCPECNRQTHVPCRSLAHPRVDCPMDEPLHAILEMADAAEWKRCFNCRTMVELHHGCNHMTCRCGREFCYVCGSVWKSCECPLWHENRLEEMAIQAVDEEVPANADIHVRQNAFHQIVEDLRQHEDNGCEHHRNSQWVWRNTGSLQCEVGNHYLPEYIFMCKGCRMRACNWCRRHRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P8H3</accession>
    <name>A0A0G4P8H3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase, family 71</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S008g000031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P8H3"/>
    <dbReference type="STRING" id="1429867.A0A0G4P8H3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF33">
        <property type="entry name" value="ASCUS WALL ENDO-1,3-ALPHA-GLUCANASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195331" evidence="1">
        <location>
            <begin position="21"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL22602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="567" mass="62492" checksum="19883716AA20765E" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P8X6</accession>
    <name>A0A0G4P8X6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S008g000202</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P8X6"/>
    <dbReference type="STRING" id="1429867.A0A0G4P8X6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF31">
        <property type="entry name" value="STERYL ACETYL HYDROLASE MUG81-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="113"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL22773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="354" mass="39723" checksum="A85DDF0573F84B04" modified="2015-09-16" version="1">MSSNHGVPQLGFWEKADIPFVHLSMYASMVYAAITGVFRGKASPKRYDHHILAAVIRKIVDRRSTRQTQYLVPPTSATYETIMKKRGLQPETVALPHDTEGHWIGNKNAKNVIVYYHGGGFAMPAIPAYFDFWLEMLKALNETGHDLAVFFPRYTLTPHATHPTQLRQAVEALRYILNETGRSPANVIIGGDSAGGNLTAATLLHLSHPHAEIEPLTLSAPLAGAFTYAPWINFSTEWPSMKDNQWKDIITPGVLTRWSDSYRGDRPADNWNEPFNAPAEWWRDAKTERILVLAGGDEILLSPIQEFVKKIKSVFGEIAFVVGADEVHDAPFYTMVKEEAQTRSELRGWLASRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P9Y5</accession>
    <name>A0A0G4P9Y5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NAD-dependent histone deacetylase, silent information regulator Sir2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S009g000029</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IFI6/IFI27 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P9Y5"/>
    <dbReference type="STRING" id="1429867.A0A0G4P9Y5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036054">
        <property type="term" value="F:protein-malonyllysine demalonylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036055">
        <property type="term" value="F:protein-succinyllysine desuccinylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01412">
        <property type="entry name" value="SIRT5_Af1_CobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009311">
        <property type="entry name" value="IFI6/IFI27-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038213">
        <property type="entry name" value="IFI6/IFI27-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027546">
        <property type="entry name" value="Sirtuin_class_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06140">
        <property type="entry name" value="Ifi-6-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="10">
        <location>
            <begin position="77"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL23089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="395" mass="41300" checksum="113115193010AF6B" modified="2015-09-16" version="1">MVQAGTWDFVNPALAACAVVRAGKVAAPKLVTAPILSGLGSNAGGVAAGSYAAAAQSSIGNVASGSLFATGQSAGAGGLGSVAVNTAAQACGVFTGLMSCKRIVALLGAGISASSGLPTFRGAGGLWRSHDATSLATPEAFDETPGLVWQFYSYRRHMALQAEPNKAHYALAELSRRNEDFITLSQNVDGLSQRANHPSKQLHLLHGTLFTVKCTNFYCNYSEDNYTDPIVPALQIPKKSSGLNPSATDKTGEEASKAIAEALDETSNEVDISDASNPIATVDKKDLPQCPECKDGLLRPGVVWFGEPLPEKTLNTVDKWIAAGPIDLCLVIGTSARIWPAAGYVHEARSQGARVAVCNMDPKDTPGELHYGDWFFQGDAGVIVPEILKSVIGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PA27</accession>
    <name>A0A0G4PA27_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX hydrolase domain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S009g000102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PA27"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL23162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="160" mass="18162" checksum="05673321A0D6EA0C" modified="2015-09-16" version="1">MAYPGIDGIVADLVPGIQWRISAAVFRYKNNGKLAVLLMKRATGEAAYPWWNIPTGPVINNDVTIRDTVERVVLDKTGLGLQGDHIIEEVESLRWGSEEEAIINLNFVIYDESSDIVAIRYDEFFEYQWVEEERIGTLAIPVSMQDVIRDGFELQRLGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAI8</accession>
    <name>A0A0G4PAI8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor, fungi</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S009g000262</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PAI8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PAI8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052761">
        <property type="entry name" value="Fungal_Detox/Toxin_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425:SF1">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="228"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="565"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="653"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="737"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="565"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="655"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="744"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL23322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="765" mass="86634" checksum="050E7104F601B7A1" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAK2</accession>
    <name>A0A0G4PAK2_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytosine deaminase</fullName>
            <ecNumber evidence="14">3.5.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Cytosine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PCAMFM013_S009g000276</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the hydrolytic deamination of cytosine to uracil or 5-methylcytosine to thymine. Is involved in the pyrimidine salvage pathway, which allows the cell to utilize cytosine for pyrimidine nucleotide synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>cytosine + H2O + H(+) = uracil + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16040"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from cytosine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.1" evidence="14"/>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PAK2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PAK2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004131">
        <property type="term" value="F:cytosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008835">
        <property type="term" value="F:diaminohydroxyphosphoribosylaminopyrimidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046087">
        <property type="term" value="P:cytidine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019858">
        <property type="term" value="P:cytosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008655">
        <property type="term" value="P:pyrimidine-containing compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000016">
        <property type="entry name" value="Cytosine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF190">
        <property type="entry name" value="CYTOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="17">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00066550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00084039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CRL23336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="148" mass="15889" checksum="9F3009DFBCCFE725" modified="2015-09-16" version="1">MEQDPGFIAAVEEAKQGLSEGGVPIGAALVSKDGKILGRGHNMRVQKGSAVLHAEMSALENSGRLPASAYDGATMYTTLSPCDMCTGACILYKVKRVVIGENKTFMGGEELLLNKGKEVVVLDNAECKELMTNFIKEKPELWNEDIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBT7</accession>
    <name>A0A0G4PBT7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S010g000230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PBT7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL23792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="438" mass="48204" checksum="FDC23F9C61A06C14" modified="2015-09-16" version="1">MMRPRDPRIRQRINQISHNLETANETAQEGLYTFSHNYISPCFDSIGNCVAACTAPCLPSREDHLRRRRRGQTEANFDFYDDWANEEEDDGLIGWGTGELDRLLAGSGLARGAADQPRRPRRMSYGTRNTRRRSTAHLPDNMDDPTVIPSSSLLGFLERFPWRFGARGVKYRPSAADLQEHPGARRYAHEDEPLMEAMDDDDDDGGPFSPTPNGRNRSATQSSRGTDNSLSSRGDLFPSDEEEDAVPLDDEFALAFGRRGTGLESDDQSGAKSEIIQSASASSLGAASSKKAKRKKKRSPKRSPSYNDAAIAQSVDTPSMTDLKTEEQRAALEEEADIARRRLAAHELALSRGLDPVGGDKPAATSDSPSIRSQDQFNTPNRTFSESSSRRLSDNQTEPFPRLSMSPSSLAVDSPGLSKTSPRAMSPHELGENTISLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBV5</accession>
    <name>A0A0G4PBV5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S010g000236</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PBV5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PBV5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051654">
        <property type="entry name" value="Meroterpenoid_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897:SF1">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL23798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="279" mass="31977" checksum="A2C04F1D8AC99965" modified="2015-09-16" version="1">MAKAESDLKSILGGGFDPHKFAWYEPELIEVPEPAKTLLEKYSKIPSEQVVDHVKKVFPYPCIGSFRFLDLSIPQSPLYPEILDRLKSGQKLLDVGCAVGQELRQLVFDGVPSENLYASDLRQDFYDIGYDLFNDHDHLKAQFIVADIFDDNSDLVKNLTHKIDIVNAASFFHLFKWNQQLLVAKRLVGLLQDKPGSLLIGRQIGLVNPPPPEDKEAAGKHYRHDPATWKKFWEQVGAETGTKWEVETRMEKWAGADKMMKDYHEGMDTFKLRFSVRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBY3</accession>
    <name>A0A0G4PBY3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S010g000232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PBY3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL23794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="63" mass="7710" checksum="751706508381D5F9" modified="2015-09-16" version="1">MEWFYWIWRTIRAVDEEYCIEDIHHFNWMGCVARNTMSCVSAITSKCKTKLTYRAHLDTPFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PC43</accession>
    <name>A0A0G4PC43_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit C</fullName>
            <shortName evidence="4">eIF3c</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 93 kDa subunit homolog</fullName>
            <shortName evidence="4">eIF3 p93</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Translation initiation factor eIF3, p93 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NIP1</name>
        <name evidence="7" type="ORF">PCAMFM013_S010g000277</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit C family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PC43"/>
    <dbReference type="STRING" id="1429867.A0A0G4PC43"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000300">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03002">
        <property type="entry name" value="eIF3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027516">
        <property type="entry name" value="EIF3C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008905">
        <property type="entry name" value="EIF3C_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITATION FACTOR 3, SUBUNIT 8 EIF3S8 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05470">
        <property type="entry name" value="eIF-3c_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="600"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="811"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="818"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL23839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="860" mass="95520" checksum="38F58E9218DB4A49" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PC79</accession>
    <name>A0A0G4PC79_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S010g000349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PC79"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL23911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="74" mass="8304" checksum="C0BDB62A984DFB1F" modified="2015-09-16" version="1">MAHYNTESMSWALVTTLFRICGTSAPVVTHHTEIPTAQVHDTMFGCRQASCDASRTRLPFGSFECLFPSHIRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCE5</accession>
    <name>A0A0G4PCE5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="10">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S010g000419</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="10"/>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PCE5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PCE5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF3">
        <property type="entry name" value="HOLOCYTOCHROME-C SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL23981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="329" mass="36731" checksum="E3DCB321700F19A7" modified="2015-09-16" version="1">MGWFWADTPQTSAVSIPHASSNASPPPGCPMHESGSKPSPSPAPVAELPSSCPMKSKDSPFYSAPKSTPAQTPQLPTDAAPQPSTLSKLNPLNYMFSSISQERAANQTVDLPVEREGSSIPRGDGEGNWEYPSPQQMYNAMLRKGHTDTPQDAVESMVAVHNFLNEGAWDEIVGWERVFAKGLKSGWEHCRRGEENLSMDLTYADENGKFDSTSEPRLLRFQGRPQEWSPKAQIYQALSWAYPSKFETSPPFDRHDWYVIRQTPWGPKEVRYVIDYYSGDPDPHGLPVFHLDIRPALDTPTAAVERLMRWGGDVWWRASGAAVREQASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCJ0</accession>
    <name>A0A0G4PCJ0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ADP-ribosylhydrolase ARH3</fullName>
            <ecNumber evidence="2">3.2.1.143</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ADP-ribose glycohydrolase ARH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ADP-ribosylhydrolase 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">O-acetyl-ADP-ribose deacetylase ARH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Poly(ADP-ribose) glycohydrolase ARH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">[Protein ADP-ribosylarginine] hydrolase-like protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">[Protein ADP-ribosylserine] hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S011g000020</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>alpha-NAD(+) + H2O = ADP-D-ribose + nicotinamide + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68792"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57967"/>
            <dbReference type="ChEBI" id="CHEBI:77017"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ADP-ribosylglycohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.143" evidence="2"/>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PCJ0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PCJ0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004649">
        <property type="term" value="F:poly(ADP-ribose) glycohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="entry name" value="ADP-ribosylation/Crystallin J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050792">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222">
        <property type="entry name" value="ADP-RIBOSYLGLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222:SF24">
        <property type="entry name" value="ADP-RIBOSYLHYDROLASE ARH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605502-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL24026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="321" mass="35573" checksum="EAB7187342B01945" modified="2015-09-16" version="1">MSSSLQSRAKGAVWGVCVADALGGPVQFRDPGTFEPITCLRFVAPFKQPAGSYSDDGSMTLALACSFNKSNMQYNHELSIRYFIEWITKGHFSTVNHSWDVGRSTRTSLRMWVKYGMEGGDLELAQVMVTDRLSHNEFSGNGSLMRIVPIGLVYWQDSELAREIARRHSRITHPSLMCVEACEAYTELVCRVMNGQTKKQIFHAVSVFPFTHPSLKERLSLHRYRTISDWKVKAPSDMTSSGWVVDTLECALWAFFKYDTWKEGALAVVNLGGDSDTAGAVYGGLAGAFYGFDDIPGEWVDGMQNKGFIESIASALSDGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCP8</accession>
    <name>A0A0G4PCP8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">N-terminal acetyltransferase A, auxiliary subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S011g000114</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PCP8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PCP8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1040:FF:000003">
        <property type="entry name" value="N-terminal acetyltransferase A, auxiliary subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1010:FF:000002">
        <property type="entry name" value="N-terminal acetyltransferase catalytic subunit (NAT1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021183">
        <property type="entry name" value="NatA_aux_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF2">
        <property type="entry name" value="N(ALPHA)-ACETYLTRANSFERASE 15_16, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12569">
        <property type="entry name" value="NatA_aux_su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000422">
        <property type="entry name" value="N-terminal-AcTrfase-A_aux_su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="77"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="578"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="603"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL24120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="834" mass="94902" checksum="10D41416B23B54B7" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCT3</accession>
    <name>A0A0G4PCT3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme/RWD-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S011g000130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PCT3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PCT3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23807">
        <property type="entry name" value="UEV_UBE2V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000026">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="6"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL24136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="139" mass="15536" checksum="7CC9FABDF8ED0DC1" modified="2015-09-16" version="1">MAAKVPRNFRLLEELEKGEKGLSADACSYGLADGEDMMMSNWNGTILGPPHSVHENRIYSVNIHCGPDYPDNPPTIQFVSRVNIPCVDSSSGKVDPTKLPTLAQWKRDNTMETVLIELRRYMALPQHKKLPQPPEGSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDG1</accession>
    <name>A0A0G4PDG1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S011g000332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PDG1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PDG1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="29"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL24338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="266" mass="29394" checksum="23939D923DABB5DF" modified="2015-09-16" version="1">MSLTFECIPLTVEGVSLNLSTIHKLNSNPPILFLHGFGSSKEDLADLTIQPSLKHHGFIAYDAPGCGHSTSNNLSATDIPFLVATAEALLARFNIDKFHLMGHSMGGLTALILANQHPDRVLSFVNIKGNLAPEDCFLSRQIFMFPANDDEAFMDAFIERTRTSGSFANAMYASTLRARVRAAAVRPIFESMVELTDHGDLMDKFLALPCPRMFMFGEEMRGLSYLPLLEKEGVELADIVGAGHFPMYSNPVEMYRRISGFLDRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDI9</accession>
    <name>A0A0G4PDI9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 14">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="10 14">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCAMFM013_S011g000313</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10 14">
            <text>6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10 14">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10 14">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="10 14"/>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PDI9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PDI9"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000002">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.320:FF:000002">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000007">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006113">
        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006184">
        <property type="entry name" value="6PGdom_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00873">
        <property type="entry name" value="gnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006765">
        <property type="entry name" value="PRK09287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000109">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00461">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="5 10 14" id="KW-0521">NADP</keyword>
    <keyword evidence="6 10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 10 14" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase C-terminal" evidence="15">
        <location>
            <begin position="182"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="36"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="78"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <begin position="132"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
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            <end position="190"/>
        </location>
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            <name>substrate</name>
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        </ligand>
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        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
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            <position position="263"/>
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            <name>substrate</name>
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            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
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        <location>
            <position position="448"/>
        </location>
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            <name>substrate</name>
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        </ligand>
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        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00002526"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004874"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CRL24319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="491" mass="53921" checksum="A49967CFDF3E3468" modified="2015-09-16" version="1">MADQAVADFGLIGLAVMGQNLILNVADHGFTVCAYNRTTAKVDRFLENEAKGKSIVGAHSIQEFCAKLKRPRRIMLLVMAGKPVDDFIESLLPFLEKGDIIIDGGNSHYPDSNRRTQYLTAKGISFVGSGVSGGEEGARYGPSLMPGGNEEAWPHIKDIFQSISAKSDGEACCDWVGDEGAGHYVKMVHNGIEYGDMQLICEAYDILKRGVGLSSKEIGDVFAKWNTGVLDSFLIEITRDILYYNDNDGTPLVDKILDKAGQKGTGKWTAINALDLGMPVTLIGEAVFSRCLSALKDERGRASSILSGPTPKFEGDKQAFVDDLEQALYASKIISYAQGFMLIQNAAKEYNWKLNKPSIALMWRGGCIIRSVFLKDITNAYRNNPDLENLLFDDFFNKAINNAQNGWRNVISKTALWGIPAPAFSTALSFYDGYRSKNLPANLLQAQRDYFGAHTFRIKPENASETFPEGKDIHVNWTGRGGDVSASTYIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PE71</accession>
    <name>A0A0G4PE71_PENC3</name>
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        <submittedName>
            <fullName evidence="14">Kinesin, motor domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S012g000184</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4PE71"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22705">
        <property type="entry name" value="FHA_KIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01365">
        <property type="entry name" value="KISc_KIF1A_KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01233">
        <property type="entry name" value="PH_KIFIA_KIFIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000357">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000021">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000047">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022164">
        <property type="entry name" value="Kinesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022140">
        <property type="entry name" value="Kinesin-like_KIF1-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032405">
        <property type="entry name" value="Kinesin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049780">
        <property type="entry name" value="PH_KIFIA_KIFIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12473">
        <property type="entry name" value="DUF3694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12423">
        <property type="entry name" value="KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16183">
        <property type="entry name" value="Kinesin_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Kinesin motor" evidence="13">
        <location>
            <begin position="8"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="1511"/>
            <end position="1622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="619"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="701"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="765"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="766"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="110"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CRL24574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1634" mass="182586" checksum="92EC3A56E947C076" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PE96</accession>
    <name>A0A0G4PE96_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger, MYND-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S012g000214</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PE96"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027796">
        <property type="entry name" value="OTT_1508_deam-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14441">
        <property type="entry name" value="OTT_1508_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="632"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="22"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL24604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1085" mass="125431" checksum="E6A09ECC35CBF66F" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PEB5</accession>
    <name>A0A0G4PEB5_PENC3</name>
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        <submittedName>
            <fullName evidence="8">Glycoside hydrolase, catalytic core</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">PCAMFM013_S012g000216</name>
    </gene>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PEB5"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050226">
        <property type="entry name" value="NagZ_Beta-hexosaminidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480">
        <property type="entry name" value="BETA-HEXOSAMINIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480:SF14">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13770)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195272" evidence="6">
        <location>
            <begin position="22"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 3 N-terminal" evidence="7">
        <location>
            <begin position="48"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL24606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="358" mass="37649" checksum="A99B451F41B38D9E" modified="2015-09-16" version="1">MKFSTQLLLPFFLALAPSASAASPSDLQAQIGHHVIFSYPGLEPPAHLLDLIKEGKVGGIILFGENVGDNLTTTIDNFQETYKQSPYYSGSPLFIMTDQEGGKVRRLAGGPVESAKQIGQAADPKAAATQMGKDAASTLEAFKNNVNLAPVLDVYREAGDFADAPQRSFSNSSRVVGTCGSAFISAQQSAGVVASAKHFPGLGAAGAGENTDLQPVTIDLTLEELRKVDMAPYTTAIAAGVDMVMTSWAIYPALDPTYPSGLSKTIIQNELRGRLGFKGVTITDAIEAGALEAFGDQAARGLLAAQAGVDILLAAKRDVTQGEDIFNSLLAALEDGSLDQRSFSAATQRILQVRKKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PED2</accession>
    <name>A0A0G4PED2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S012g000229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PED2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL24619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="64" mass="7239" checksum="226071DDE9972A0D" modified="2015-09-16" version="1">MLRVRSTLPHSRGREKKLHKIAWHGTPRFATFLGKIAENPKNPDPTQTQPSLGPQIGLQTIQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PER5</accession>
    <name>A0A0G4PER5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Endoribonuclease L-PSP/chorismate mutase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S012g000366</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PER5"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43857">
        <property type="entry name" value="BLR7761 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43857:SF1">
        <property type="entry name" value="YJGH FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL24756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="130" mass="14595" checksum="516E8B0430A55C10" modified="2015-09-16" version="1">MQFFNYAGTEANSESFHYSQAVRIGNTIKTSGQGGWDESGNVHPDVEQQVAIAFENVEKALKSVDSRLSWENVYAVRSYHINVDQTFDMVTGNFKKVLPGHRPIWTCVEIGKLGIEGMVIEIEVEAHCPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PF10</accession>
    <name>A0A0G4PF10_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="13">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S013g000105</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL24862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PF10"/>
    <dbReference type="STRING" id="1429867.A0A0G4PF10"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000047">
        <property type="entry name" value="Mannosyl-oligosaccharide alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF101">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 13 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195419" description="alpha-1,2-Mannosidase" evidence="14">
        <location>
            <begin position="21"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="501"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="332"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CRL24862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="511" mass="56517" checksum="E95EE3271CC8420F" modified="2015-09-16" version="1">MRISSLSFPLVLGLVGSSAAYPHPEPEVILRRESENQAKADAVKEAFQHAWNGYIEHAFPHDELHPVSNGYGDSRNGWGASAVDALSTAIVMGNKDAVQKILDHIETIDFSKTEDEVSLFETTIRYLGGMLSGYDLLKDPATKNLAPKSAQVDALLTQSKKLGDVLKFAFDTPSGVPYNNLNITSKGNDGSRTNGLAVTGTLVLEWTRLSDLTGDDEYAKISQKAQSYLLNPQPSSGEPFPGLVGSNINISNGHFTDGAVSWNGGDDSFYEYLIKMYVYDPKRFASYKDRWILAAESTIKHLQSHPAPRPEVTWLASYYNGQYDLSSQHLTCFDGGSFILGGTVLDRPDFIDFGLKLVNGCEATYNQTLTGIGPDSWGWDPKKVPSDQKDFYEKAGFYMNNGAYNLRPEVIESFYYAYRVTGNEIYRDWVWNGFKAINATCRTGSGFAAVSNVNTAGGGSKYDNEESFLFAEVMKYAYLVHAEDAPWQVQKGQKNAYVFNTEAHPVRVSHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PF31</accession>
    <name>A0A0G4PF31_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CDR ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S013g000154</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL24911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4PF31"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000881">
        <property type="entry name" value="ABC multidrug transporter A-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="513"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="549"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="625"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="654"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="768"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1188"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1223"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1264"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1309"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1341"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1372"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1473"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="150"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="850"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="807"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="826"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="82" mass="8860" checksum="852A1A7C63DD85DA" modified="2015-09-16" version="1">MGEGDGKGKERRCGTSPVRARSDGAGAIEAPNPPNTPEGPLHEPLRSGLMAQTFAFLYVAKSTTRSLPHSMHIGSVFRKYMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGX2</accession>
    <name>A0A0G4PGX2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S015g000177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793148">
        <property type="protein sequence ID" value="CRL25591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PGX2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL25591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="52" mass="5786" checksum="246394F094C422FD" modified="2015-09-16" version="1">MTAADTDSLCDPLLFPYPAARVLCAVPEQDLHLYVVFRTSSLYGETKQVLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PH38</accession>
    <name>A0A0G4PH38_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S015g000280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793148">
        <property type="protein sequence ID" value="CRL25694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PH38"/>
    <dbReference type="STRING" id="1429867.A0A0G4PH38"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF12">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL25694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="264" mass="27804" checksum="6FD61B6B3E317E44" modified="2015-09-16" version="1">MFPGVAVITGAGGTGIGAATTKAFAAAGCTQIGITDLNQESLDQTAKVVTSTYPDVRLLAMAGDVADDQFADAFINAVVQRFGRVDYAVNCAGVLGKPIRSAEMSLEEFDRVNNINYRGCWLSSRAELRQMVTQSALPSHDSNRPPQRGAVVNVSSQLGVVSRPGAPAYCASKAAVIGMTRADAIDYSRDGIRVNCVCPGVIETPLVMEKPEVREAIMPAVETAPMKRMGQPAEVADAILFLCSTQASFVQGHAMVVDGGYVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PI15</accession>
    <name>A0A0G4PI15_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ankyrin repeat-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S016g000124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793149">
        <property type="protein sequence ID" value="CRL25843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PI15"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL25843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="52" mass="5832" checksum="149BA89B1E73BD48" modified="2015-09-16" version="1">MVTFLVEQGGAPDLQDPYRRTPIGYAIRNGHYEIEQILKDRVNVGMSLAQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PIV8</accession>
    <name>A0A0G4PIV8_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LSM complex subunit LSM3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LSM3</name>
        <name evidence="12" type="ORF">PCAMFM013_S017g000101</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793150">
        <property type="protein sequence ID" value="CRL26118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PIV8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PIV8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01730">
        <property type="entry name" value="LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000036">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034105">
        <property type="entry name" value="Lsm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040002">
        <property type="entry name" value="Sm-like_LSM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13110">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="14"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL26118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="96" mass="10820" checksum="5B121F46B54857B7" modified="2015-09-16" version="1">MADTEDTGGPSVSEPLDLVRLSLDETVFVKLRGDRELKGRLHAYDSHCNLVLGDVEETIYVVEEDENEEETLRTIKKQEEMLFVRGDSVVLISPQA</sequence>
</entry>
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    <accession>A0A0G4PJA8</accession>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793150">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="L-amino acid oxidase LaoA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
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    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF342">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195393" evidence="1">
        <location>
            <begin position="22"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="187"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL26291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="698" mass="78547" checksum="D7B17A53908A6149" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJJ4</accession>
    <name>A0A0G4PJJ4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40/YVTN repeat-like-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S019g000021</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJJ4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJJ4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="rRNA processing protein Pwp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="PWP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="256"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="299"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="391"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="39"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="492"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="502"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL26605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="532" mass="59212" checksum="6051C98856042E93" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PK64</accession>
    <name>A0A0G4PK64_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S019g000166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PK64"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL26749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="59" mass="6557" checksum="223FC0DBE1FEC634" modified="2015-09-16" version="1">MAAHPLLDLNAAELKQAASLFARSIVARNWSSKPLPLRSRPSNLFSNTSRRKKMAPVCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PK74</accession>
    <name>A0A0G4PK74_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Permease, cytosine/purines, uracil, thiamine, allantoin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S018g000265</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PK74"/>
    <dbReference type="STRING" id="1429867.A0A0G4PK74"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015851">
        <property type="term" value="P:nucleobase transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
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                <person name="Dupont J."/>
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</entry>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793154">
        <property type="protein sequence ID" value="CRL27272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PLG8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL27272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="57" mass="6447" checksum="79639B97FB63E5AB" modified="2015-09-16" version="1">MCFLIVQIGASITQEELFAYTNAYFLTNEKYQLSRRYVRFDVDELCNTAVAAGGKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PLH9</accession>
    <name>A0A0G4PLH9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S021g000197</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Sterol O-acyltransferase that catalyzes the formation of stery esters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793154">
        <property type="protein sequence ID" value="CRL27282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PLH9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PLH9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034737">
        <property type="term" value="F:ergosterol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008204">
        <property type="term" value="P:ergosterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF9">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000439">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="481"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="510"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000439-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CRL27282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="533" mass="61585" checksum="42DB79763A5D40B1" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PLL3</accession>
    <name>A0A0G4PLL3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclin-like F-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S021g000235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793154">
        <property type="protein sequence ID" value="CRL27320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PLL3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PLL3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001369">
        <property type="entry name" value="F-box domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF190">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="178"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="604"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="604"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL27320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="736" mass="81693" checksum="23CD77E7622AA685" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PLM9</accession>
    <name>A0A0G4PLM9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Patatin-like phospholipase domain-containing protein</fullName>
            <ecNumber evidence="10">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S020g000222</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lipid hydrolase.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Probable lipid hydrolase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <topology evidence="10">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the PLPL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="HG793153">
        <property type="protein sequence ID" value="CRL27063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PLM9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PLM9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07232">
        <property type="entry name" value="Pat_PLPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF66">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE PTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7 9 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="12">
        <location>
            <begin position="277"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="633"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="9">
        <location>
            <begin position="308"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="633"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="669"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL27063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="716" mass="82214" checksum="E3F4B3681EFFA19D" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PLU6</accession>
    <name>A0A0G4PLU6_PENC3</name>
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        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">PCAMFM013_S022g000057</name>
    </gene>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793155">
        <property type="protein sequence ID" value="CRL27377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PLU6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL27377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="40" mass="4685" checksum="D8F3F92415E04E6F" modified="2015-09-16" version="1">MGVAVLFFDRPRRGAYDLREEIHLVSHEERLLKLDETSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PLZ0</accession>
    <name>A0A0G4PLZ0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S022g000024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793155">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="42"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL27344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="289" mass="32585" checksum="E8E51EC4260C96E2" modified="2015-09-16" version="1">MSHDGNPFNVTGFVFAEVPTNYFYGPTYNPLPSEIGLKSSIHPSVPQSESWLTGSVSSTVTPSPRPISRYREIRPRPAPTSPQLETKNEEKQRVRRPTKKARRTVSGVTGATNHSVGRNETSTAKKPRMSSHDSATQGPRSRSRDYPPYNQEGSPQAPVEALQKALKAQVLHSLRVLRKIAMDYRAFNLDSEIIDGWVAEIEGVDTKTIPIASSMTVQMFVPFERLNSILTECITATGPMRSFTIRDQALELLEYILTHAEKYYLVQSAQVYFDIGRWIERLNQTKMRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMU2</accession>
    <name>A0A0G4PMU2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S023g000132</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793156">
        <property type="protein sequence ID" value="CRL27674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PMU2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PMU2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19146">
        <property type="entry name" value="AKR_AKR9A1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF7">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="28"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL27674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="398" mass="44598" checksum="E48B62EECE79DFE3" modified="2015-09-16" version="1">MFSRAPTPKSYLGRYRLLAPTAGVKVSPLCLGAMNFGDGWKDRLGECNKETSFQILDTYYENGGNFIDTANNYQAEESEKWLGEWMEVRGVRDQIVLATKYTSPYRIHNQSEIQANFIGNNAKSLKLSVDASLRKLKTDYIDLLYVHWWDFSTSIEEVMTSLNQLVLSGKVLYLGISDTPAWIVTKANQYARDHGLRPFSVYQGKWNAATRDFERDIIPMAASEGMGLAPWGSLGSGAFKTTAQREELAKSGNPGRQNPATERDIAVSKVLEVVAERHGTALTSVALAYVMRKAPYVVPIVGGRKVEHLLNNIEGLGVDLSDEDLKEIEAAYEFDIGFPMNFLFRGDDVVKEAHPGNSFLNIGGKFDYPDLVRGPFNVKLGMMLFGLVFHWLWRILTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMW5</accession>
    <name>A0A0G4PMW5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclin-like F-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S023g000157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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</entry>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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            <end position="99"/>
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        <location>
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    </feature>
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            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL28437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="403" mass="45515" checksum="7E7D1A31720E148E" modified="2015-09-16" version="1">MLRLRYLLRSPHARSSLFSPAHARSNLSNPENVRHVRFRRPWIRSFISKCLLYGTAFHLWSTFVLVRFDDDTDDADIPPVGNSEEIAPRETSLGGGETTGKEVENEGVLFIPLSWSRLQQGELYATSDPEWQEFVKLSKDRKKLQKLRDELATIVLDNAGRQMSQILGEPLSLTGFWLVHQFPNRAPPGYVRSGVEIKNDSISWVAKPMDPEIGDRLQTFMKPVHVALAIRDAYLVLLLRQLDRFKKPAGEPLDAFDFLNDSSAAPGDEGGNWIGRKDQSKLQPPLTDGLKENMPPNTENPNYHPSSLISLLQRLPLPDLGPGSDLHLASQAFKLRLNHERAQTPGSTRRGSFFITGPVGLKGPNGFCRFEVRGEYDPAKREWRTVEMTLKDLNMRRQKALGS</sequence>
</entry>
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    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793161">
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    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL28527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="33" mass="3581" checksum="46D696BF3D3F028C" modified="2015-09-16" version="1">MTGNILNASSRVQVIEQLLPEKDGSTDMVACFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQ72</accession>
    <name>A0A0G4PQ72_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PCAMFM013_S028g000068</name>
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        <lineage>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793161">
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    </dbReference>
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        <location>
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            <end position="28"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
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    </feature>
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            <begin position="329"/>
            <end position="395"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL28515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="559" mass="58964" checksum="E04E206AB74D2644" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQJ0</accession>
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        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000202">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.7, whole genome shotgun sequence"/>
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    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
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    </dbReference>
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        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF0">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN EST1A"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
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        <source>
            <dbReference type="EMBL" id="CRL28659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="799" mass="90445" checksum="4C6A9E97EDD04C53" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQV3</accession>
    <name>A0A0G4PQV3_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">hydroxymethylglutaryl-CoA lyase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S030g000067</name>
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    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Dupont J."/>
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                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:24404"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="4.1.3.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate metabolism; (S)-3-hydroxy-3-methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMG-CoA lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.4" evidence="3"/>
    <dbReference type="EMBL" id="HG793163">
        <property type="protein sequence ID" value="CRL28780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQV3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PQV3"/>
    <dbReference type="UniPathway" id="UPA00896">
        <property type="reaction ID" value="UER00863"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004419">
        <property type="term" value="F:hydroxymethylglutaryl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046951">
        <property type="term" value="P:ketone body biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07938">
        <property type="entry name" value="DRE_TIM_HMGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000201">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043594">
        <property type="entry name" value="HMGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004283">
        <property type="entry name" value="PRK05692.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738:SF17">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="7">
        <location>
            <begin position="9"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL28780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="309" mass="33329" checksum="AFB4D191256F7B63" modified="2015-09-16" version="1">MTVQNLPTVRIVEVGPRDGLQNIRDYIPTSTKLELIRRLKETGLGTIELTSIVSPRIIPQLADSRDVLGDEGIRRMGGKDLRFPVLVPTVRALDIAVQYGVREIAVFISATEGFSKANINCSVEQGIERARNIASLALKSNIAVRGYVSCLFLDPYDGPTQPASVLRCVKELLDAGCYEVSLGDTLGVASPSNVRSLISFLFDNDIPREKLAGHFHDTYGQAAANVWEAYNCGLRVFDSSIAGLGGCPFAPGAKGNVATEDLVYMFHNAGINTGVDLSKLVDTGVWISEQLTKTTGSRAGIGRVARECN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PR64</accession>
    <name>A0A0G4PR64_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S029g000079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793162">
        <property type="protein sequence ID" value="CRL28663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PR64"/>
    <dbReference type="STRING" id="1429867.A0A0G4PR64"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195557" evidence="1">
        <location>
            <begin position="26"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL28663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="254" mass="25112" checksum="13E8A2F841F0D057" modified="2015-09-16" version="1">MVSTTINFSGLMCLVLALGPATVLAAPQLPGLPFPEIINHGPETTNLGPGNSETSAGSGVKVGIPGGPYVNVGAGFIDTHRGPCGPGSGDDHLAGAGVDVGIPGGPRVNVGNGEHSHQDGYPCPEPPAVVVVPTATANPPPVVVVPTTTVNPPTEIVTPPVETAHPPTWTGVPAILPPTFTTPISGPLTTAPAAWVPVPAQSSTPLIHHAVPTASASPSAVPSVPVVPVFNAGSSLVPGSVLAVALPVIVAFFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PR90</accession>
    <name>A0A0G4PR90_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Glycoside hydrolase, family 31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PCAMFM013_S029g000052</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Glucosidase involved in the degradation of cellulosic biomass. Has both alpha- and beta-glucosidase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793162">
        <property type="protein sequence ID" value="CRL28636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PR90"/>
    <dbReference type="STRING" id="1429867.A0A0G4PR90"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000089">
        <property type="entry name" value="Alpha-glucosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1760:FF:000005">
        <property type="entry name" value="Putative alpha-glucosidase AgdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF67">
        <property type="entry name" value="ALPHA_BETA-GLUCOSIDASE AGDC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 14 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195563" evidence="16">
        <location>
            <begin position="20"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="18">
        <location>
            <begin position="126"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="17">
        <location>
            <begin position="281"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="19">
        <location>
            <begin position="748"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="450"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="469"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="534"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CRL28636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="952" mass="106477" checksum="4F7A545ABC209A28" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRC1</accession>
    <name>A0A0G4PRC1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Arginine biosynthesis bifunctional protein ArgJ, mitochondrial</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Glutamate N-acetyltransferase</fullName>
                <shortName evidence="10">GAT</shortName>
                <ecNumber evidence="10">2.3.1.35</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">Ornithine acetyltransferase</fullName>
                <shortName evidence="10">OATase</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="10">Ornithine transacetylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">Amino-acid acetyltransferase</fullName>
                <ecNumber evidence="10">2.3.1.1</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">N-acetylglutamate synthase</fullName>
                <shortName evidence="10">AGS</shortName>
            </alternativeName>
        </domain>
        <component>
            <recommendedName>
                <fullName evidence="10">Arginine biosynthesis bifunctional protein ArgJ alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="10">Arginine biosynthesis bifunctional protein ArgJ beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S029g000087</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(2)-acetyl-L-ornithine + L-glutamate = N-acetyl-L-glutamate + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:15349"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.3.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="10">The alpha and beta chains are autoproteolytically processed from a single precursor protein within the mitochondrion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ArgJ family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.35" evidence="10"/>
    <dbReference type="EC" id="2.3.1.1" evidence="10"/>
    <dbReference type="EMBL" id="HG793162">
        <property type="protein sequence ID" value="CRL28671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PRC1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PRC1"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006592">
        <property type="term" value="P:ornithine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02152">
        <property type="entry name" value="OAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.340:FF:000002">
        <property type="entry name" value="Arginine biosynthesis bifunctional protein ArgJ, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2330.10:FF:000001">
        <property type="entry name" value="Arginine biosynthesis bifunctional protein ArgJ, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.70.12:FF:000002">
        <property type="entry name" value="Arginine biosynthesis bifunctional protein ArgJ, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2330.10">
        <property type="entry name" value="arginine biosynthesis bifunctional protein suprefamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.340">
        <property type="entry name" value="ArgJ beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.70.12">
        <property type="entry name" value="L-amino peptidase D-ALA esterase/amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01106">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002813">
        <property type="entry name" value="Arg_biosynth_ArgJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042195">
        <property type="entry name" value="ArgJ_beta_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00120">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003802">
        <property type="entry name" value="PRK05388.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100">
        <property type="entry name" value="ARGININE BIOSYNTHESIS BIFUNCTIONAL PROTEIN ARGJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100:SF0">
        <property type="entry name" value="ARGININE BIOSYNTHESIS BIFUNCTIONAL PROTEIN ARGJ, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01960">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="DmpA/ArgJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 10" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_5023286270" description="Arginine biosynthesis bifunctional protein ArgJ alpha chain" evidence="10">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023286269" description="Arginine biosynthesis bifunctional protein ArgJ beta chain" evidence="10">
        <location>
            <begin position="225"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="10">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="10">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="10">
        <location>
            <begin position="224"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL28671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="460" mass="48434" checksum="0C0642AEB0F661B9" modified="2015-09-16" version="1">MATSLARMLKGQVRCYSAPLDMAIPASKQRYIPTTGTYPQGFQVSGTHVGVKASNTRFPDLALIASETPCSAAAVFTTNKFQAAPVQVSRKTLQSRKGNGIRAVVINSGCANAVTGKGGLEDAVQMGRKVDECSGVENDSSLVMSTGVIGQRLPISKILDRIPTAHSTLASTHEAWLTTARAICTTDTFPKLLSRTFTLPSSPDRTYSLAGMTKGAGMIHPNMATLLGVLCTDAAVEPAALQSILKHAVSRSFNSISIDGDTSTNDTIAVLANGAAGGEIVRAPAASASADYTALQGVVTDFAQELSQLVVRDGEGATKFVTVRVRNSPDYESGRQIASTIARSPLVKTALYGKDANWGRILCAVGYTQGVAEGTVVPERTSVSFRPVDGSEVLKLLVNGEPEAVDEKRASAILQNEDLEIEVDLGGGEQGAAGCGGEDAVYWFCDFSHEYVTINGDYRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRS8</accession>
    <name>A0A0G4PRS8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S030g000110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793163">
        <property type="protein sequence ID" value="CRL28823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PRS8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PRS8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="478"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="950"/>
            <end position="1095"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL28823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1274" mass="143330" checksum="3830F9E05E9AB3C1" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PS78</accession>
    <name>A0A0G4PS78_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-histidine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S034g000063</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methyltransferase superfamily. METTL18 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.85" evidence="3"/>
    <dbReference type="EMBL" id="HG793167">
        <property type="protein sequence ID" value="CRL29265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PS78"/>
    <dbReference type="STRING" id="1429867.A0A0G4PS78"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018064">
        <property type="term" value="F:protein-L-histidine N-tele-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF39">
        <property type="entry name" value="HISTIDINE PROTEIN METHYLTRANSFERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL29265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="362" mass="39150" checksum="2347988033AB3743" modified="2015-09-16" version="1">MAFSFGFSGDDIDIDDSEINNDFSDVPSQQVVGNSLPELVKAVKHDMNEWLSILPSQIFYNKLAISDTPLAVARREIFDIRTQLMAEDSAGHDNEELIAGIEKGDITPNFYEGGFKTWECALDLAKLSLNEDILNESSDSPADIHIIELGAGTAVPSLTLFARLLSQAEPGQSQRKTLFTFADYNSDVLRLVTLPNLLLTWHNSRSQTAVSAASTAPDQDEELDITPELVQEFKDDLAQRGISVDFVSGAWSPEFVDLVFSSGDSARKTLVLASETIYSPASLAAFSETLLALLRRSNTASAKSRALVAAKKVYFGVGGGVDEFLAVLGNVCANELDVQQKLNVQSEGVGRVVLEVVPSSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PSB6</accession>
    <name>A0A0G4PSB6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S032g000042</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793165">
        <property type="protein sequence ID" value="CRL29006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PSB6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PSB6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="12"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="100"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL29006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="245" mass="27603" checksum="D725913F51031638" modified="2015-09-16" version="1">MHPSSGGAQKLQAKSSNIKLVEGNLDEPEKIFDNANKVTSQPIWGVYSVQVPVPGGSNQEVEERQGKDLVDAALKNNVKHFVYSSVDRGVEKAKGSEMTWTILRPVAFIENFTPDFFGKVFATCWKKTVKEKPLQLISVGDIGFFGAQAFMYPNQYQNRGVSLAGDELTYGEMAKIFQNKTRKSIPTTFGFVAKALMAMMKDLGYMFQWFYDVGYGANIPELRKVHPELRDFRTWLEKDSGFDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PSV0</accession>
    <name>A0A0G4PSV0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histone deacetylase complex, subunit 2/3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S036g000036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <dbReference type="EMBL" id="HG793169">
        <property type="protein sequence ID" value="CRL29452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PSV0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PSV0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070823">
        <property type="term" value="C:HDA1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038609">
        <property type="entry name" value="HDA1_su2/3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021006">
        <property type="entry name" value="Hda2/3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11496">
        <property type="entry name" value="HDA2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="377"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="421"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="821"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="923"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1094"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="426"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="833"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="851"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1100"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1124"/>
            <end position="1137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL29452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1148" mass="127637" checksum="76206458A0C59835" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PT47</accession>
    <name>A0A0G4PT47_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aminotransferase, class-II, pyridoxal-phosphate binding site</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S035g000003</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793168">
        <property type="protein sequence ID" value="CRL29308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PT47"/>
    <dbReference type="STRING" id="1429867.A0A0G4PT47"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF12">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="59"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL29308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="486" mass="54419" checksum="1CC111B2D3A7332A" modified="2015-09-16" version="1">MTGNKISPEIDDEKPGVLHREDTIDQEKQKQLKDVDYSGATKKTDPAEIRLVRKLDLWIMPTLWLMYWLNYLDRNAIALARLNGLEEDLNLSSSQYQTCVSILFVGYIAGQVPSNMLITRLRPSYYMASAMAAWAVVSALTALAKDFTGLLLVRFFLGVTETPYYPGALYMLSIFYTRKEIATRISILYTGNILATAFAGLIAAGIFHGMDDLAGITGWQWLFILQGAVTFVVAVCSVFVLPDDPLHTRWLTDDERQLAHERILADTVGARHQTSTFSGVKEAAKDPRVWLFAFMQHMHLAANGFKNFFPTAVETLGFNTTITLVLTCPPYLIAGIISVYWSWNSGRMNERTWHITFAKAVAIFGFVLGCATLNTGARYFAMCVFTIGTYAVNSIILGWVSSTCGQTKEKKASALAIVNTCANISFIWTPYLWPSSDEPRYTIAMSSSASFSITCAACAWAMKIWLQRANRKIRQNNDESDLYYAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PTC5</accession>
    <name>A0A0G4PTC5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipopolysaccharide-modifying protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S038g000038</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793171">
        <property type="protein sequence ID" value="CRL29635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PTC5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF104">
        <property type="entry name" value="PROTEIN CAP1, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05595)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195613" evidence="2">
        <location>
            <begin position="25"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="3">
        <location>
            <begin position="340"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL29635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="629" mass="72571" checksum="D1A22189F5558078" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PV81</accession>
    <name>A0A0G4PV81_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S050g000027</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793183">
        <property type="protein sequence ID" value="CRL30380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PV81"/>
    <dbReference type="STRING" id="1429867.A0A0G4PV81"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF74">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="489"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="87"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL30380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="579" mass="64657" checksum="F680FD96DE6B5126" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVK5</accession>
    <name>A0A0G4PVK5_PENC3</name>
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        <submittedName>
            <fullName evidence="2">GTP-binding nuclear protein Ran-related</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PCAMFM013_S045g000058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793178">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008812">
        <property type="entry name" value="Ran_GTP-bd-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31010:SF2">
        <property type="entry name" value="RAN-SPECIFIC GTPASE-ACTIVATING PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31010">
        <property type="entry name" value="RAN-SPECIFIC GTPASE-ACTIVATING PROTEIN 30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05508">
        <property type="entry name" value="Ran-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="648" mass="72289" checksum="E6F64DBACBCE52D9" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PW65</accession>
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        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">PCAMFM013_S051g000012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793184">
        <property type="protein sequence ID" value="CRL30409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL30409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="138" mass="15862" checksum="CCA5DA4075C3C367" modified="2015-09-16" version="1">MHQIGLLPQFQHVGTEEENDDELTARASMAMTSERLNEEIGRRIDNVKALFIRMVGRIHIHNHGEYNIALHNLAAWAFFDGYWNGLYNERCNGNCQTSMMQVTNEPQNLVWYLISTRMTDVMVLDGKINPCESNYKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PWQ1</accession>
    <name>A0A0G4PWQ1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">dihydroxy-acid dehydratase</fullName>
            <ecNumber evidence="14">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PCAMFM013_S059g000019</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:27695"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IlvD/Edd family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14"/>
    <dbReference type="EMBL" id="HG793192">
        <property type="protein sequence ID" value="CRL30778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PWQ1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PWQ1"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.80:FF:000001">
        <property type="entry name" value="Dihydroxy-acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050165">
        <property type="entry name" value="DHAD_IlvD/Edd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002068">
        <property type="entry name" value="PRK00911.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000:SF13">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="18">
        <location>
            <begin position="58"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="19">
        <location>
            <begin position="403"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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            <dbReference type="Pfam" id="PF24877"/>
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            <dbReference type="EMBL" id="CRL30778.1"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="597" mass="63691" checksum="45196EE039FCED7D" modified="2015-09-16" version="1"> </sequence>
</entry>
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    <accession>A0A0G4PX88</accession>
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                <person name="Dupont J."/>
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</entry>
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    </evidence>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Conseiller E."/>
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    </evidence>
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    </evidence>
    <sequence length="350" mass="39920" checksum="5DCF8C90CF7CC2F6" modified="2015-09-16" version="1">MGRKLESLPTEILRVVVSHLFIQDMKHLASASKRLRDVCLPYLFHNVVFSFSDSGLDGLRLLMQSDVRQYVVSFTYLIPELLRPETMDFEFFRCNILPPGNYAMWLKTDRSEPAELYVPYVLVYDTFSAICKEQQKIVENQEDAIALSAVFRLLPRLTELGLRFCQTLVQEHWVGCFMDQTVERYTYGHHLCIISNALKIGRDAGVFIPTVHLSGLELPYYCSLNTPKAHTLSIHLFGLLSCARNLRLSGSGSPMKSLSHTTLHLQQFDLCCLTVLQATLNEFLQNNMNSIESFAFHHVTLIGLGFTEEDSALISPEMCRSSLRMDWSIMYWTTSPCLVCGHDGWRVSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NTA7</accession>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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    </feature>
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            <begin position="37"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL17288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="287" mass="32342" checksum="35317DC712CD2223" modified="2015-09-16" version="1">MNSFSPRDFQEWVDRRQSTQSASTVSSASTSVLFPSPATSPGSSSRKQSWQFYDDVVRLELTPSVQISFVKNGQLFKLKYKFIDICKDSTGALRCLELGGGLGQQTPFVHGFSNTKLPVPHLEHPKSGDDYPLRISFMDQQTVQTGSTVFMTQLSYKFDHWDDCVRFQELLLGSKLIFIGGMAEAKSKGRGEECISQNLRILRGHNGKRVMLFFANSQRRELKRYVSIPLNCIGSIKPPKKAGRPALLDLNPNFEILSQMRNLTIQFLDDDDCTAFCQMLSYDLTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NTC5</accession>
    <name>A0A0G4NTC5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar protein sorting-associated protein 74</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S001g000292</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Mediates the cis and medial Golgi localization of mannosyltransferases through direct binding of their cytosolic domains. Involved in vacuolar protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">Golgi stack membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GOLPH3/VPS74 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NTC5"/>
    <dbReference type="STRING" id="1429867.A0A0G4NTC5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048194">
        <property type="term" value="P:Golgi vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3630.10:FF:000002">
        <property type="entry name" value="Vacuolar sorting-associated 74 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="entry name" value="yeast vps74-n-term truncation variant domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704:SF2">
        <property type="entry name" value="GOLGI PHOSPHOPROTEIN 3 HOMOLOG SAURON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704">
        <property type="entry name" value="TRANS-GOLGI PROTEIN GMX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL17332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="354" mass="39621" checksum="869139EE04916121" modified="2015-09-16" version="1">MASAAGGLTRRRGAGRVAGADEQDDSRVSSPISRNGSAMDNRGPETSFTSAENGHKIAFDPRDISENEERGKQPKLTLMEDILLLGLKDKQGYLSFWNENISYALRGCIVIELALRGRISMQKDSSRRRFPLADRIIEVIDDTLTGEVLLDETLKMMKSSEKMSVNSWIDLLSGETWNLMKIGYQLKQVRERLAKGLVDKGILRTEKRNFLLFDMATHPVADGGAKDELHRRVRNICSNRTVIIPPSPWLPEDAEYRYLRSISMVCAAYAANVLENALVTMSHEARERAFAQVDELLAEYSQWPFGRKAGGSQAIGANLAQVVNEEINRNKDKELQMEIVAACLSVFTRLDSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NTL5</accession>
    <name>A0A0G4NTL5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11 12">Catalase-peroxidase</fullName>
            <shortName evidence="11">CP</shortName>
            <ecNumber evidence="11 12">1.11.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Peroxidase/catalase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">katG</name>
        <name evidence="14" type="ORF">PCAMFM013_S001g000366</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 11 12">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11 12">
            <text>H2O2 + AH2 = A + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:30275"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="11">Binds 1 heme b (iron(II)-protoporphyrin IX) group per monomer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the peroxidase family. Peroxidase/catalase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.21" evidence="11 12"/>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NTL5"/>
    <dbReference type="STRING" id="1429867.A0A0G4NTL5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070301">
        <property type="term" value="P:cellular response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00649">
        <property type="entry name" value="catalase_peroxidase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08200">
        <property type="entry name" value="catalase_peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000002">
        <property type="entry name" value="Catalase-peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000004">
        <property type="entry name" value="Catalase-peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000002">
        <property type="entry name" value="Catalase-peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01961">
        <property type="entry name" value="Catal_peroxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000763">
        <property type="entry name" value="Catalase_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00198">
        <property type="entry name" value="cat_per_HPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011635">
        <property type="entry name" value="PRK15061.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30555:SF0">
        <property type="entry name" value="CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30555">
        <property type="entry name" value="HYDROPEROXIDASE I, BIFUNCTIONAL CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00460">
        <property type="entry name" value="BPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 11 12" id="KW-0349">Heme</keyword>
    <keyword evidence="7 11 12" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 11 12" id="KW-0408">Iron</keyword>
    <keyword evidence="4 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 11 12" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="13">
        <location>
            <begin position="126"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="11">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="cross-link" description="Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-92)" evidence="11">
        <location>
            <begin position="229"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="CRL17406.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
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</entry>
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    <accession>A0A0G4NTZ0</accession>
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        </submittedName>
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    </gene>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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            <end position="185"/>
        </location>
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            <end position="228"/>
        </location>
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            <end position="548"/>
        </location>
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            <end position="173"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="294"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="350"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="412"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL17434.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
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        </alternativeName>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">FM 013</strain>
        </source>
    </reference>
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        <reaction evidence="21">
            <text>a sterol + UDP-alpha-D-glucose = a sterol 3-beta-D-glucoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22724"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15889"/>
            <dbReference type="ChEBI" id="CHEBI:37424"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.173"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:22725"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>ergosterol + UDP-alpha-D-glucose = ergosteryl 3-beta-D-glucoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61836"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16933"/>
            <dbReference type="ChEBI" id="CHEBI:52973"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:61837"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 28 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1429867.A0A0G4NUB7"/>
    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
    <dbReference type="GO" id="GO:0034045">
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Glycogen Phosphorylase B"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ATG26_PH_GRAM2"/>
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        <property type="entry name" value="EryCIII-like_C"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF25">
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    </dbReference>
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        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="18" id="KW-0753">Steroid metabolism</keyword>
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    <keyword evidence="17" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
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        <location>
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            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
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            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="456"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1312"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1353"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="131"/>
        </location>
    </feature>
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        <location>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
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        <location>
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    </feature>
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        <location>
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    </feature>
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        <location>
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    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="618"/>
        </location>
    </feature>
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        <location>
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            <end position="1325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="1353"/>
            <end position="1365"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00017894"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00029843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CRL17650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1372" mass="153213" checksum="FC3CC7CA8289257A" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NV71</accession>
    <name>A0A0G4NV71_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S001g000946</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NV71"/>
    <dbReference type="STRING" id="1429867.A0A0G4NV71"/>
    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
    <dbReference type="InterPro" id="IPR054448">
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    </dbReference>
    <dbReference type="Pfam" id="PF22943">
        <property type="entry name" value="HTH_68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helix-turn-helix" evidence="2">
        <location>
            <begin position="167"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL17986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="214" mass="22795" checksum="30CAD7F8233DFBE4" modified="2015-09-16" version="1">MGSAASKPVKSAAGAASRRQYPKQPAPPPRGPRKAPKETKAASAPSPTPTSKSKPQASPSTPRAPTAPSQGPTYHSKEQASSVKSDAIDMDGRDPDFAASLRSIGPVNPSPTFSNSSTFNRPGSMQTVFPHASNPALLVVTARQRLMEAAEKEAEHFGHAGHPGRTFLDALTIQQVLTMRDKQGMRHGDIERFLGLKKGVLERLGKDEIVSRIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NVP7</accession>
    <name>A0A0G4NVP7_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCAMFM013_S002g000015</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">High-conductance magnesium-selective channel that mediates the influx of magnesium into the mitochondrial matrix. Essential for the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing. It also suppresses a variety of mitochondrial intron mutations and its absence may disturb the assembly of mitochondrial membrane complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homopentamer. Forms homooligomers. Interacts with MFM1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NVP7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045016">
        <property type="term" value="P:mitochondrial magnesium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12823">
        <property type="entry name" value="Mrs2_Mfm1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000005">
        <property type="entry name" value="Inner membrane magnesium transporter MRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.330:FF:000002">
        <property type="entry name" value="Inner membrane magnesium transporter mrs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039204">
        <property type="entry name" value="MRS2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890:SF0">
        <property type="entry name" value="MAGNESIUM TRANSPORTER MRS2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890">
        <property type="entry name" value="RNA SPLICING PROTEIN MRS2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22099">
        <property type="entry name" value="MRS2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="540"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="551"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU366042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CRL18145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="586" mass="64355" checksum="07851EA903A140F9" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NVY5</accession>
    <name>A0A0G4NVY5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S002g000108</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NVY5"/>
    <dbReference type="STRING" id="1429867.A0A0G4NVY5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21176">
        <property type="entry name" value="LPMO_auxiliary-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046936">
        <property type="entry name" value="BIM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046530">
        <property type="entry name" value="BIM1-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992:SF1">
        <property type="entry name" value="COPPER ACQUISITION FACTOR BIM1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20238">
        <property type="entry name" value="BIM1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005194823" evidence="9">
        <location>
            <begin position="18"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Copper acquisition factor BIM1-like" evidence="10">
        <location>
            <begin position="16"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL18238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="227" mass="23443" checksum="A93EF1AC9A85E790" modified="2015-09-16" version="1">MKFSLLAFTAIVPLASAHFKLMYPTSRGFDEDTMTNFPCGGMSQSSNRTKLPLSGGSFPVALEMHHSQTAVEVLLSLGSDPGDNYNIVLSPTFQVKGLGEFCLPHVEINEKLIGRNLTDGMNATVQVQTNGDPSGGLYACADIQFSSDVTYQTPSACTNNTNLAATAFTGVSASRNANESTSEGQAQSGSSSSSSTSTSTSKGAAVPMQTAAWGVLGAALVGGIAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NW49</accession>
    <name>A0A0G4NW49_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CCT-beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S002g000160</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NW49"/>
    <dbReference type="STRING" id="1429867.A0A0G4NW49"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03336">
        <property type="entry name" value="TCP1_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000002">
        <property type="entry name" value="T-complex protein 1 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012716">
        <property type="entry name" value="Chap_CCT_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02341">
        <property type="entry name" value="chap_CCT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL18290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="531" mass="56891" checksum="CCE9074665D9BBC4" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWB7</accession>
    <name>A0A0G4NWB7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S002g000164</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWB7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF19">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01812)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="58"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL18294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="496" mass="55302" checksum="31FDC5C5E0F8671E" modified="2015-09-16" version="1">MGNSFEKPTESRSSDPEKILDSKDPLAAAGFEDPDAGLSDEEKAEIDRKLLWQLDIRLVPWLSLLYLVSFLDRTNIGNAKLVGLQTDLNMTNAQYNATLTIFFVSYSVFEPATNVLLKRLRPSIFIPLIMMAWGICMTFMGFVKNYNGLMAVRWFLGLSEAGLFPGVGYFLSCWYKRSEFGVRMAIFFSAAALAGSFGGLLAAAIAKMDGVAGKPGWSWIFILEGLLTFFIGVASFWCVYDFPDQARFLSDDDRKRVLRRLAMDQQSSAEHEEFKMDYFWSSLKDWKTYTGAVIYMGADGSLYAFSLFVPTIISELLLSVPPYAAAAVLTVTVGFIADRTRQRGLCNIAVSFLGMIGFAMLLGCESAGARYAGTFLGAMGIYPAIANTISWTSNNTEGVYKRGVSLGFIIGWGNLNGIVSSNIYRDDDKPKYYPGHGVVLGYLVLFLFGGSVVQYLLLRRENGKRRRGERDHWIEGLDQNQIELLGDKRPDFIYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWN6</accession>
    <name>A0A0G4NWN6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Coatomer subunit beta'</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PCAMFM013_S002g000336</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasmic vesicle</location>
            <location evidence="1 13">COPI-coated vesicle membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Golgi apparatus membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="13">The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the WD repeat COPB2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWN6"/>
    <dbReference type="STRING" id="1429867.A0A0G4NWN6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22947">
        <property type="entry name" value="Coatomer_WDAD_beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000016">
        <property type="entry name" value="Coatomer alpha subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000001">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016453">
        <property type="entry name" value="COPB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF2">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005567">
        <property type="entry name" value="Coatomer_beta'_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <keyword evidence="5 14" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="93"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="136"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="180"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="224"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="16">
        <location>
            <begin position="318"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="17">
        <location>
            <begin position="594"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="817"/>
            <end position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CRL18466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="871" mass="96423" checksum="25471BEE93A7222D" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXV4</accession>
    <name>A0A0G4NXV4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S002g000751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NXV4"/>
    <dbReference type="STRING" id="1429867.A0A0G4NXV4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF8">
        <property type="entry name" value="DUF4220 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL18881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="484" mass="55913" checksum="2F8D9E2608F3BD29" modified="2015-09-16" version="1">MWGVEKKNGKEQTGRDPTKDPLSDPTQENPTKAYRSVPTMNDTIPTPHGWVNEPDGRGTWGILFTCVVTIILCCWTSVAPNLPAKSDGEFRRWRYKLDLACITLLGSEFILMLSVGQWSSARRSVKDFHEAGYTEWTIKHAFFADMGGFFIKPLENDLPSFPLDAKQLYILVKDNYLEYPNLKQEEIEDRNKSGGLARLFTIAQALWFTLNCIFRFAQGIFVTTLEITTLSFILAFLITSYCWYHKPMDVNTPITLQLNTSVTTIRNNHQVPGSKWYETPFEYLSRDQGFLARFWRYYMQLLHYMHVPLATRPRRRPYDRIPSHNFLNTDTRAEIIAAPTIVFFSALYLIAWNSHFPTETEKLLWRIASVNTLAYALIGAPLCAYFQKTIFRAELRQERAQATLNHKPEPKRWIGRLASKLRNIDPEQDPQLEIPLRALIPVSFLCGMYCVSRGFILTEDLIGLRSLPESAFQTVSWSRYVPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYP1</accession>
    <name>A0A0G4NYP1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-amylase</fullName>
            <ecNumber evidence="4">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PCAMFM013_S002g001072</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL19202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="CDD" id="cd11319">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Alpha-amylase A"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Golgi alpha-mannosidase II"/>
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        <property type="entry name" value="GH"/>
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        <property type="entry name" value="Glyco_hydro_b"/>
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    <dbReference type="PANTHER" id="PTHR10357:SF215">
        <property type="entry name" value="ALPHA-AMYLASE 1"/>
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    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="A_amylase_dom_C"/>
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        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="2"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195007" description="alpha-amylase" evidence="18">
        <location>
            <begin position="18"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="19">
        <location>
            <begin position="30"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="517"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>substrate</name>
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    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="315"/>
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        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="16">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="14">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="47"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="258"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="474"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
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    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
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    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
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        <source>
            <dbReference type="PIRSR" id="PIRSR001024-1"/>
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    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-2"/>
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        <source>
            <dbReference type="PIRSR" id="PIRSR001024-4"/>
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    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-5"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CRL19202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="558" mass="60891" checksum="A0DCE75D2F06A0E6" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZ67</accession>
    <name>A0A0G4NZ67_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Vesicular-fusion protein SEC18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCAMFM013_S003g000143</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AAA ATPase family.</text>
    </comment>
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        <property type="protein sequence ID" value="CRL19352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
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    </dbReference>
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        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:SNARE complex disassembly"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPase_AAA_core"/>
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        <property type="entry name" value="ATPase_AAA_CS"/>
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        <property type="entry name" value="CDC48_domain_2-like_sf"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="Vesicle-fus_ATPase"/>
    </dbReference>
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        <property type="entry name" value="VESICLE-FUSING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VESICULAR-FUSION PROTEIN NSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CDC48" evidence="15">
        <location>
            <begin position="173"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="315"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="597"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="311" mass="34804" checksum="53C7835F73496956" modified="2015-09-16" version="1">MGTTEFPRRGDGGTANASKTFVGDLTFHHFNMILSGACTGITCLVIFIVMARHAVHLSNPNQQVKAKFFLSLKIQKRYSKAKRTDGLSWLKSTWFFVLQYPIVTFILAIAQSITQAQGTFCLEGNKVYFAHLWITIISIISLAMAMINIMGFHSSLKPYMEGQKPMMKLLAFKMVVGLEFLEQIIFMVLDSTGTLKPSATLSYADTIIGLPTLIICLQVVPFAFLFYYAYSIKPYTALSVNCTSNLQYLAVVDSETGSPRVKRYQGGPLGVYAWLALFNPGELFRDIKSTFNMFRDSKTEVETGMSLDSRM</sequence>
</entry>
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    </dbReference>
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        </location>
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</entry>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <begin position="1"/>
            <end position="26"/>
        </location>
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        <location>
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            <end position="192"/>
        </location>
    </feature>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="192" mass="21164" checksum="2BB99D6B3BA6A9C6" modified="2015-09-16" version="1">MPQVIRRASWLPVLVVALLAVSTVNAHPIHQTDEAMEKGQASKLESRSPRLIPDTQKYVHDLLQGLGLVEPTATATATPTPTPTATPTASVETKQDLDNMKPTQTTNIVYSSSTSYTPTYSSNEAGYTHTVKHIHSNNRPIENVQIGQGWNGDKKITTEDIPVVFDTLYRELEHRLKNMIDSSDEIGLDGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZA1</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
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        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL19334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="73" mass="8236" checksum="AA0820D3675F8891" modified="2015-09-16" version="1">MDWLTNLFKGKDSAKTAQEKVEKRGSKRHSQNVLAREKELRRGKDNGGKKARFFWGSPGQTYESNVRGPGEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZI5</accession>
    <name>A0A0G4NZI5_PENC3</name>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-grasp fold, A domain"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
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        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
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        <property type="entry name" value="ATP-GRASP ENZYME FSQD"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="308"/>
            <end position="560"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL19424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="677" mass="75037" checksum="1B75325785154102" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0B7</accession>
    <name>A0A0G4P0B7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S003g000524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P0B7"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL19733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="105" mass="11993" checksum="3790BEF43D685B03" modified="2015-09-16" version="1">MVFASLAAVLAGPAISFTIMASSSPFLSWLFETEMELGVTLVGLPYFRLAGLFVLYLVGLILILLWRREQRILYERSEAGVELKWNSRKGQRQGPYQSGTYQWMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0Q2</accession>
    <name>A0A0G4P0Q2_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S003g000645</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="5"/>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P0Q2"/>
    <dbReference type="STRING" id="1429867.A0A0G4P0Q2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL19853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="233" mass="26279" checksum="A9B6741A01DB6C74" modified="2015-09-16" version="1">MSSHSALLAIAMLVAGYCLIITHVDPNPQLAKKDCNRADRVRFPTGRALPVFSQVCTVIAIYHALLTVITRHTPTRVSQICPLAHNTNPELFAWNMASIVPLLLIYVGTYIRISAYGGLGKLFTLHLVPPDHLVTTGIYRWIQHPSYTGIGMIWWGCFALFLRWDATPACWIPTLALSQFYGWGASILTAIAGSVVWFFGGRVLDEERMLQRKFGQQWEQWHRSTKRLIPGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0Q7</accession>
    <name>A0A0G4P0Q7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S003g000650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P0Q7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL19858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="116" mass="13090" checksum="A66AC5D7644BD575" modified="2015-09-16" version="1">MPDTKMAMRKIEKCIGPNHEIHIPEGTELIELTVTLGRDKQIEQVEINCLPYTGNEVAEVGGIFTDASPFQYKFDTTEVTGSVTFNRDHESIGLLIDMTWNTKQQVDVQFPVVVFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0T5</accession>
    <name>A0A0G4P0T5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thiolase, active site</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S003g000686</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Lacoste S."/>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
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    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051411">
        <property type="entry name" value="Polyketide_trans_af380"/>
    </dbReference>
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        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
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        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="11"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL19894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="298" mass="32207" checksum="8491C58D32E5E91E" modified="2015-09-16" version="1">MSAISIQKGPIQLAGLLFTPTTTSDKTPALIIVHPGGGVKEQTAQVYAKKLATHGFTVVCYDASHQGESGGEPRFLEDPNERVTDVYAVIDYLQKDESVDTEKIGVVGICAGGGYAVAATKADHRLKAVAAISMVNIGDSAGLGWYGDEESGKNIKLLEQAAAQITAEARGAERAVAPYVPPQLDDNTPYDLKEAHNYYLGPRAQHPRAKNTMLFLSFPRVVTFDAFHLAETFLTQPALLIAGENAGSLWHTEKLHKILDGKAKKVILSKGTHMDLYDKEEFVEPAVKSVAKFMQANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P146</accession>
    <name>A0A0G4P146_PENC3</name>
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        <submittedName>
            <fullName evidence="9">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S003g000828</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="55"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
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            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
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            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL20036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="787" mass="87563" checksum="F3DEB1B1DADA9508" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P1P6</accession>
    <name>A0A0G4P1P6_PENC3</name>
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        <submittedName>
            <fullName evidence="6">Peptidoglycan-binding lysin domain</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF1">
        <property type="entry name" value="PEPTIDOGLYCAN-BINDING LYSIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195339" evidence="4">
        <location>
            <begin position="20"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="5">
        <location>
            <begin position="373"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="244"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="266"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="333"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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            <fullName evidence="6">UDP-glucose-glucosephosphate glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S005g000507</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-glucose 6-phosphate + UDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="2.4.1.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.15" evidence="6"/>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P4W1"/>
    <dbReference type="STRING" id="1429867.A0A0G4P4W1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000007">
        <property type="entry name" value="Trehalose-6-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000035">
        <property type="entry name" value="Trehalose-6-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012766">
        <property type="entry name" value="Trehalose_OtsA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02400">
        <property type="entry name" value="trehalose_OtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF106">
        <property type="entry name" value="BCDNA.GH08860"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="482"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL21343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="505" mass="56881" checksum="6D3E531F9365AABE" modified="2015-09-16" version="1">MPSIEPKNEARLLLVSNRLPITIKRSDDGKYDFSMSSGGLVSGLSGLSKSTTFQWYGWPGLEVPEPEIPVVKQRLKEEYGAVPVFIDDDLADRHYNGFSNSILWPLFHYHPGEITFDESAWEAYKEANRLFAQAIAKEVQDGDLIWVHDYHLMLLPEMLREEIGDSKKNVKIGFFLHTPFPSSEIYRILPVRNELLLGVLHCDLIGFHTYDYTRHFLSSCSRLLGLATTPNGIEFQGKIITCGAFPIGIDPEKFKEGLKKEKVQKRIAMLEQKFQGVKLMVGVDRLDYIKGVPQKLHALEVFLSDHPEWVGKVVLVQVAVPSRQDVEEYQNLRAVVNELVGRINGKFGTVEFQPIHFLHKSVNFDELIALYAVSDACIVSSTRDGMNLVAYEYIATQQKRHGVLVLSEFAGAAQSLNGSIIVNPWNTEELAGAYQEAVTMSDEQRALNFAKLDRYVSKYTSAFWGQSFVTELTRISAHSADKFQSKKLAESDANETDVPPTTQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P506</accession>
    <name>A0A0G4P506_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S005g000553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P506"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL21389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="150" mass="17011" checksum="F0C4471A265C34BA" modified="2015-09-16" version="1">MAENTAEHQMEAGKTFEDTVMADEVKTTEVWPWDLIPKKKKKKKRLYEYDDLPQESKHQRYARRKRAQRSKAIQRAKEAAFDAAKAAAERNQELPASTTAPLHPTITTHPASLEVDLLSGDKDEVMKEAEVEVGSDSAVMTLPFREKESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P551</accession>
    <name>A0A0G4P551_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sas10/Utp3/C1D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S005g000594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P551"/>
    <dbReference type="STRING" id="1429867.A0A0G4P551"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF9">
        <property type="entry name" value="NEUROGUIDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL21430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="379" mass="42224" checksum="418835F5578A9299" modified="2015-09-16" version="1">MAPAQASARPQSLSTLLETLNTCLSTTSSSLPKPHKDAPSDVTIEPPQDGISLLDTKSEILLSYLQNLVFLIIFQLRNVSAKQTPKEKSQSTDNSLEDDIRKKLIELRVFLERGVRPLEGRLKYQVDKVIKAAEDAERTEKAQPAKTKKSRKAATSDSEASSGEDEDASGSEDEEDIDEMAYRPNVSAFSKGVAEQKKAQPSKGAVEGPGDGIYRPPRIMPTSLPTTERRERQDRRPIRSNVIDEFVSAEMSSAPMAEPSIGSTIIDGGRTVKSKKDREREAERTTYEETNFVRLPKETKKELAKRGRGKDTTYGGDEWKGLNEGADNIERLTRRTKSNGAALEKSRKRVRNEDGQRGDGVGMGQIFDKRRKKVDSWKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5R6</accession>
    <name>A0A0G4P5R6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc finger, C2H2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S006g000177</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P5R6"/>
    <dbReference type="STRING" id="1429867.A0A0G4P5R6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="179"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL21637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="208" mass="22811" checksum="00977882B481A258" modified="2015-09-16" version="1">MTEPVQHGLSYLDQEGGVQWNESDPPFSYIFADHWSPLVDGFPYDSFLESTSAPLTPNPVVSTSHGTPHKIADTQYDKRSPDEDGAAAGDIPSLDLHDGMSDITSTIISTADEEQASTTIADDSPQRSTSYGKVSMGVKSSRGSPLKCKWKHCEYSGGFSQMGALLRHIKTKHISPGLYECPEGECRKSFNRKDNLIAHIRNVHRATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5X4</accession>
    <name>A0A0G4P5X4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S006g000256</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P5X4"/>
    <dbReference type="STRING" id="1429867.A0A0G4P5X4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL21716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="350" mass="40021" checksum="DCC067D62974ECD4" modified="2015-09-16" version="1">MGPGSSDPLADHSSSCLESLPVEILQLIFLHSLEVNLPRASPRLSQALSTPLLYTWLIRLAFSSPNSGSREGFFTPDFLPPPLDFWALSWKERQKLQTDLLACRWCTFPLLRKCQREYVAHAIRRKCAGLVFHPDDQEMLSNLDPRFENLEACDWAVLGRRGKGDLVIPAQLGDALRTPSSRNVDRKVAIWFHFGAVQIRKPHEIYHENDLFRLPCSAAIGPGRIPDKVLRSPWSDAQFEFLQLLSSDFYLDEDEARPDRSSEITYRLIRTRKIEPFSRLLRISFRAANCRVPARWPLQPSHYSLVRRCGSGPGDPFANVILNERWDDMPTEAKQDLLRYVDSSSPKDGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P643</accession>
    <name>A0A0G4P643_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S006g000313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P643"/>
    <dbReference type="STRING" id="1429867.A0A0G4P643"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025340">
        <property type="entry name" value="DUF4246"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049192">
        <property type="entry name" value="DUF4246_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049207">
        <property type="entry name" value="DUF4246_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119">
        <property type="entry name" value="IFI3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14033">
        <property type="entry name" value="DUF4246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21666">
        <property type="entry name" value="DUF4246_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4246" evidence="2">
        <location>
            <begin position="11"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4246" evidence="1">
        <location>
            <begin position="95"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL21773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="592" mass="67766" checksum="C1871A24CC4F4EE2" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P651</accession>
    <name>A0A0G4P651_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Crotonase, core</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S006g000332</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P651"/>
    <dbReference type="STRING" id="1429867.A0A0G4P651"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000048">
        <property type="entry name" value="3,2-trans-enoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF1">
        <property type="entry name" value="ENOYL-COA DELTA ISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL21792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="276" mass="30552" checksum="1A0AB26D607C858B" modified="2015-09-16" version="1">MSNENLITVTYQDRVAIVTLNRPDKLNALNADLYYLLAERLREIDAREDIFITILTGKGRFFSAGADVTSIRPGSDNADMNVRREIVRGFVANNLDATRAFYTHSKILVAALNGPAVGLSAALVAHADFIYAAPHTFILTPFSSLGLVAEGGASRAFVERLGIAKANEALIMSKRITCDELVSTGFVNKVITPESGKKEDSDGFLKKVLEEVDDRLGTHLNQSSLLKIKELVRRPEREILDRQNGAEAFMGLERFMMGIPQEEFRKLASGEKRHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P653</accession>
    <name>A0A0G4P653_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S006g000328</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P653"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL21788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="84" mass="9744" checksum="5D85A3D6824DAE3D" modified="2015-09-16" version="1">MIDVEITTQALSNHRDDIVLPLAERLMDDNKLVCLVDPPRKNHVGVSFNDALNWLIECLAYNWPMYPDEFDLDRMAIEMHAFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6J5</accession>
    <name>A0A0G4P6J5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S006g000485</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P6J5"/>
    <dbReference type="STRING" id="1429867.A0A0G4P6J5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03445">
        <property type="entry name" value="Thioesterase_II_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF35">
        <property type="entry name" value="ACYL-COA THIOESTERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="3">
        <location>
            <begin position="24"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="4">
        <location>
            <begin position="200"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL21945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="320" mass="36046" checksum="CE4BBC11C1A23846" modified="2015-09-16" version="1">MATTLAEHVSLQKLHDHYVSTHLPQKMGNSAPIAYGGYAIALAIHAAYKTTPDGFHLHSALGHYLRPVSTEINLICTPVKLRQSKSFVTYRVAVEQNDPSTSQRHLCMELLADFHRDEPSVLTFSSEPTRSYSHWRDCMPWDRLVEDWVKAGKISEPHFKAFNTLFGLSRNLYEGRPCPEGVTAQNLMGMTKTVKTSQEELSPTEKSSADWFRVKHPLQTEGEQIASLGFVMDGVLSFLPLAHNHMFFDDVGACSSLDFALRIFTPRPKMDEWHLREVINHHAGNGRTYSESKLWDEGGNLVASMTQQSILRVPVKAARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7E3</accession>
    <name>A0A0G4P7E3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S007g000201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P7E3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL22220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="65" mass="7704" checksum="8525943267BB5235" modified="2015-09-16" version="1">MKQLVASFLFHYFRLDEWEMLPVNYGMPADLEWRNPIHNAVMTTFGIVVFWQGRGNITLEEGMVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7U2</accession>
    <name>A0A0G4P7U2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S007g000356</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P7U2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF140">
        <property type="entry name" value="ATPASE, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="56"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="299"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="316"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL22375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="391" mass="43288" checksum="47F78F27EA5E197C" modified="2015-09-16" version="1">MKPSMFRGYQFALNSAQVPKGPIVPKFEVVASRSLSLPLSSLDSHLLPCVYDASCAFGWDDTFMVCAMLLNILFALCGITGAFYGMGQRSRDLIERGTMETAMFWWWLGQTSYVWTCAMAKISIAFALLRLTVSNVHKLVLWAVIGVTCTIGLVFWFMLTLQCQPVEFFWQQVRLMSDPQANVSGTCMNLDNIIAMAYVYSITATMCDLTLGLLPIALVWNLQMNLRTKCALAGILGMGCIASAAVIVRIPFLHDYKDTDFLYATANISIWSNVEASLGIAAGSLVTLRPLFRWFRDPSSMGESRSKSKRTGGSVPLSSINGVRSTTSNPQYWRPDLDREDHTVITTVHTSNGSDGSRTSSQEDLNPTHGGTFFQGVNVQKTFYVSEDQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P822</accession>
    <name>A0A0G4P822_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S007g000390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P822"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL22409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="270" mass="29962" checksum="77AA3FC2CB483E17" modified="2015-09-16" version="1">MVYTVCLDFEQTPTSSTDVGDPLEALSTLHSSFLGMMNWTGGQLQRHHNRSGLLTKAQKQNFARARLQKGAVIPPPSPFRDFPDIAFKGSSTRDKDEDEEAETNGNQVTEEPVSHETGGQSSHGDDLTEVKRQLLKEPDWAAVSATRPLELAFTSVEEVERFGKRRKLNDKDRKRMVTANNNGSTFFERPKPSRKGRNSSSVIDTIEEDIQFEINGRPVAQSNDSSGVAMNSISSQSMLLDHEGSPIVEQDLGKENLTATWITNLFPPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P8K1</accession>
    <name>A0A0G4P8K1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome b-c1 complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Complex III subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S008g000082</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with cytochrome c oxidase (complex IV, CIV).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UQCRQ/QCR8 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P8K1"/>
    <dbReference type="STRING" id="1429867.A0A0G4P8K1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.210:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.210">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004205">
        <property type="entry name" value="Cyt_bc1_su8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036642">
        <property type="entry name" value="Cyt_bc1_su8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119:SF2">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX UBIQUINONE-BINDING PROTEIN QP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02939">
        <property type="entry name" value="UcrQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81508">
        <property type="entry name" value="Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL22653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="97" mass="10880" checksum="977AEFA1DDCC14D0" modified="2015-09-16" version="1">MGGSVDPKNGHFIGNWGEFGCPTPQRIATYSLSPNRQRPMAGAAHAAIFNVFRRFRHQVLYVVPPFVAAYAMMNWAIERNEYLNSKPGRLLEGGNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P8X7</accession>
    <name>A0A0G4P8X7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S008g000181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P8X7"/>
    <dbReference type="STRING" id="1429867.A0A0G4P8X7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40468:SF1">
        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40468">
        <property type="entry name" value="YALI0A15257P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL22752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="353" mass="38576" checksum="BB701D4F84543164" modified="2015-09-16" version="1">MPLSQPGSAEKTIRKIDIAQVSLSLQDRLGLAKLKYQHGRLHGLNSNQQDGRSALESDKPSDSSSEFSRSRCETPFTSPPLQASTYSKELPRSARNKHAVTFNSRVMQPMLSASRKRLRSDSDSERPAKAPRVSWKSSYRLPESSPGMNRHRTSRRTQAPFMSEATILEMSSPVYPGPSEEIDPDLPLHSFQNMSSIVGSSPPRTPPPKHMRLPRSNQPQNHEDGADLLLYLANSPTPARVARGNGNQAFPPSTPPSQHAVLPGMTPTMGGGMFANISTPNQQFNFADFVNVTPSPAQPTWGGRTPGNPARTPLTSNRKRLNFDALVPPSNTSPRLRGKETGLALQLGGELHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P9X8</accession>
    <name>A0A0G4P9X8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S009g000058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P9X8"/>
    <dbReference type="STRING" id="1429867.A0A0G4P9X8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL23118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="128" mass="13855" checksum="E987DDEC9259B52E" modified="2015-09-16" version="1">MGEDSSFNRQTTAVAGGSSAQPTPANNVGGGEGWGDRLWLGGKEEGLGHKVATNPRETMGDFLALQDQKTRGQNKFIQRENLVDTNVKPMNAQGEPTCATEDHSFMTRKAGDPDTYPGWGTFKNFFGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PA89</accession>
    <name>A0A0G4PA89_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mannose-1-phosphate guanyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GDP-mannose pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">GTP-mannose-1-phosphate guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S009g000155</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>alpha-D-mannose 1-phosphate + GTP + H(+) = GDP-alpha-D-mannose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="EC" id="2.7.7.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="3"/>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PA89"/>
    <dbReference type="STRING" id="1429867.A0A0G4PA89"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06428">
        <property type="entry name" value="M1P_guanylylT_A_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="10">
        <location>
            <begin position="17"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="11">
        <location>
            <begin position="310"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL23215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="440" mass="48552" checksum="4E7863B9034F7DAD" modified="2015-09-16" version="1">MLNIPMRDNHNTQASTKAVILVGGPSRGTRFRPLSLDVPKPLFEVAGHPIIHHCLKAVAKVPDVREVMLVGYYDESVFRDFIKDASKEYPQLRILYLREYTALGTAGGLYHFRDAILKGKPERLLVLNADVCCSFPLGEMMRLFEEKDAEAVILGTRVSNDTATNFGCIVSDSHTKRVLHYVEKPESHISNLINCGVYLFATECIFPAIRSAIKRRTTRPRLLSYPSSDNLESSFIANGDDEDAEKSEVLRLEQDILSDLADSNRFFVHETKDFWRQIKSAGSAVPANALYLQKAFQAESPELTAPSATIVPPVYIHPTASVDPTAKLGPNVSIGPRVVVGAGARIKDSIVLEDSEIRHDACVMHSIIGWSSRVGAWARVEGTPIPVGSHSTSIVKQGIKVQSITILGKECGVGDEVRVQNCVCLPYKELKRDVSNEVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAY6</accession>
    <name>A0A0G4PAY6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S009g000423</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PAY6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PAY6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF4">
        <property type="entry name" value="ESTERASE ALNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL23483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="221" mass="24372" checksum="7307FCBBB547E44E" modified="2015-09-16" version="1">MPLRLLCLHGWGTNQKILQSQLSGLMHELQRDNTATFSFLEGDVDSAPGPGIAGYYDGPYYSYYRFPRTFSHEDSDESDILEAYEQLSETVALEGPFDGVLGFSHGGTLAAGFMIHHAKMNPNEPALFRCAIFINSLPPFRMEPGKRPVVDEGLEGFISIPCVHIAGAKDPLFEYSMTLYRLCAARYSTFTVHGKGHDVPSDGKHVAIIASAIRKLSSQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAZ9</accession>
    <name>A0A0G4PAZ9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="2">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S009g000438</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="2"/>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PAZ9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PAZ9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF26">
        <property type="entry name" value="FAD-BINDING 8 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="7">
        <location>
            <begin position="244"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL23498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="434" mass="49446" checksum="EDAB9CE0FC418ED5" modified="2015-09-16" version="1">MHLPLNVFVLYLYIVAALATLLIFKSCLVAALKFLLYPSGPAADFVSRHILLPHLFRRRSLWGPMTRIRAFLHAAHLAATFACNIIGVEDISTARSRAGSLATLHIASLAVFSQLTFGAALLNISLPTQQHLHASVGVMGVFQSLLHVIFALQAISFDLRVTIQRYGFAAIISVGVLSFLVLPWIRRRAYEFSTNMHICLGLATIVVLWLHLRNRFHLDGYLLIGSIGLFFTTTLIRIAYQIYRNWRGLAVAEKTKKLEGAVMLSFSPTRPWKIRAGQYLYLRIPAVRLFSFAESHPMNILWWEESNTDRKTNHITVLAKVDTGFTRRLDSCQYNSFRIILDGPYGKPKDTDHYDSFVFIATGIGISAQLAYLKELIMGRDRGQRLRRVCLIWQVDEEDQIWYSVGLCILMQIPQKERRVEKEDEVFNTMENLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PB69</accession>
    <name>A0A0G4PB69_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40/YVTN repeat-like-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S010g000011</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the THOC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PB69"/>
    <dbReference type="STRING" id="1429867.A0A0G4PB69"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000870">
        <property type="entry name" value="WD repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040132">
        <property type="entry name" value="Tex1/THOC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3 THO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="149"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="306"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL23573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="444" mass="46984" checksum="C243BDC5FD0E36A8" modified="2015-09-16" version="1">MATPDKDSPAVSGSPKAVSEHSPIQSVHRSSNNIKPKLLGPIASTSAIASATGSNAGRRPVLRQLLEEEDEDMAPASRRELLHKDHFAFVFGSVKTQNYLDPVSKGPGSHTIRTLAWNPTGQLIATGSADRTLRIWNPERPHVRYSTELRGHTAGIEKALFNPVRDAELASCSADGTVRFWDVRSKTCVSRLDVGGEAFTLSWSADGSTMIVGKKDDTLIPVSVKFPSSPTAHPDGVNALNLPSSTPGATTYTALDPHPQTVQTNATAFSWCMPTPERPEQHAFVTTGEGKVKIMSYPSFDIIHTLNAHTSACLSIALAPTGRYLAVGGSDALISLWDTTDWICRRTLSSENGGAIRGVSWSFDGRYIVGACDELGCGGNGLEIFHAESGDSIYTIPTAGINAGVSAVAWHPSRYWLAYSTTTDGPGSSSAGGLKIVGAAGGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBW4</accession>
    <name>A0A0G4PBW4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fatty oxidation complex, alpha subunit FadB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S010g000192</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PBW4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PBW4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF8">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE NADP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="4">
        <location>
            <begin position="15"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL23754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="309" mass="33382" checksum="C5400258DDD7E1B5" modified="2015-09-16" version="1">MAQNVHRFLQQDKISQLRFWNRTASRGAPLESLGGIGCESIAQLVAECDLIFISTSDDAALNAIVDQILTVKDIDGKLFVDTTTVHPNTTKETNEKLKKRNASFVAAPVFGATPAAESGTVLMAMAGPSQAIDKITPFGKGVIARDVMIVSDQPEKATLLKTLGNFLVAGTMEIVGEAQVLAEKSDLGTDMLEKLLELNFGGLMHSSSRRMTQGVYLPEEGQAPWSNLNLGIKDVQHGISCAQDVGARLKVAEVALDNMVRAKDFSDVHGGRPLDSSSGYGIIRQDSGLDFENTFVKERDARKEDDSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCG3</accession>
    <name>A0A0G4PCG3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S011g000009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PCG3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL24015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="183" mass="20185" checksum="E2CD1B9FFA4B5F19" modified="2015-09-16" version="1">MGIQRALPNSITPRYSDRLSEIFSSGSPEPSNICSPLNSTTGSVDVQSDDEGSDTSMDECSDEEDAHGQHTLEVESPVEHQHQNVEPPSPRYPTDSTSTMIECMAELDVRVQSVEDSLVSQNLWNSETHRKVVYLMDIIETMGKDMAALKEQVERAMAGIKKVERWDASTAHCSESGVAIIQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCM4</accession>
    <name>A0A0G4PCM4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S011g000037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
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                <person name="Bensimon A."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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            <begin position="19"/>
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        </source>
    </evidence>
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    </evidence>
    <sequence length="318" mass="31154" checksum="7DE428CC8F0BB7E2" modified="2015-09-16" version="1">MKASFIATVAALAGSAFAAPTPAGGLDSVLNGLKVGDITKELKLNEIPVVSKLSDVTKVLNLPSPASPSASSAPAVQDGHLVQNLGPQLDNILTVVGPDASTLLIELSPEVSALVSGLGLGALGAPLGSIVASASGVGALVTGLGPVVDGLVTVVGADVGALLISLSPEVAGLVSGLGLPTVGVPVGTVVATLGKNLKRGEIVQDVAPKVKTTLTVTGKNAKNLLIELSPSVTSLVAGLGLTTISGPVGSIVAEASSVGDLIVHISEPVEDLLHIVAKDGKHLLIKLSPSVVALVTGLGLPTVATPLGAILTTVAQNL</sequence>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="33" mass="3801" checksum="43666E0D51A3F43B" modified="2015-09-16" version="1">MGFDTVSKGNRYMEAYCGPDLRVWSCRAQCLDK</sequence>
</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="341" mass="37188" checksum="B4C654A1F6B70DE1" modified="2015-09-16" version="1">MPTSVFLLGPGFIGGEILDLLLISKHKVTTLVRRESADADYTNLGVETVVGDLGDSSVIRDRVAVSDIVIHTATADHLPSVHAIIEGIRQRAAQGLRTIYIHNSGATLLSDTAQGEYKSDTIYGDELPGEIQALPNSASHRQIDLVIVRAGQELASHAKMAIMIPPLIYGVTTRENRLSIQLPTLIRYSIKHGYAGQIGKGRAVWNQVHVRDLARGYMVLLHWMERAPVTEIALNPYFFCENGQELSWGECAAEIGLILKSAGRIDQSTPKPIPKEEWGDLFGDYSGMVVGSNARNKANRLRKLGWAPLEKGTLASLAEDEIPIIVKETGEFKGYASVVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PE06</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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            <end position="21"/>
        </location>
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            <end position="205"/>
        </location>
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        <location>
            <begin position="134"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="134"/>
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        </location>
    </feature>
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        </location>
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        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL24568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <sequence length="205" mass="21171" checksum="37A170BCA8DA55BE" modified="2015-09-16" version="1">MARFPVVFVLLALLAATLATAFNQTLELENSNCDNNCYFDSFPGGSCTDDPACMCDKQQYREAYFCCMKDCNPNVMPDSITRQHRECKARNMDFTFDAEAICGVKLTTSAGFLVAAATTTSNPTAATVTVTAAADSTTTGDSKSSTASGSNPSAASLTSTQEASSTGNQTSSASSTPTPTNGAPGKGAIGKVAMVLVGVYAVVLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PE47</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="PANTHER" id="PTHR43544:SF7">
        <property type="entry name" value="NADB-LER2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL24592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="228" mass="24470" checksum="78A7E17A177C064A" modified="2015-09-16" version="1">MAPTIVLITGANRGIGKGILELYLQKPNHTVIAANRDPSHPTSNALADLPKAEGTTLEVIKLDALSPTDPAAAVKALAAKGITHIDILIANAGIALSWPKVSEVKVEDIQKHVDVNVYGFIRLYQAFRPVLKEAQAPKLVTIGSSSAFLTHWYTKAISAEDPWLTAFPLDPGWVQTELGNRGADAFGIEKAAITVEESVTGVVKVIDASTLETHSGKLFKYDGNQEPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PEX7</accession>
    <name>A0A0G4PEX7_PENC3</name>
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        <submittedName>
            <fullName evidence="10">Mg2+ transporter protein, CorA-like</fullName>
        </submittedName>
    </protein>
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        <name evidence="10" type="ORF">PCAMFM013_S013g000131</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1429867.A0A0G4PEX7"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:metal ion transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF121">
        <property type="entry name" value="ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="965"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="999"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="81"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
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            <end position="146"/>
        </location>
    </feature>
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            <end position="214"/>
        </location>
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        <location>
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            <end position="264"/>
        </location>
    </feature>
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            <end position="297"/>
        </location>
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        <location>
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            <end position="321"/>
        </location>
    </feature>
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        <location>
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            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <end position="1105"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
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            <begin position="11"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
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            <end position="535"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="8">
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            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="565"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL24888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1121" mass="126507" checksum="2DD032D771FA2144" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PEX9</accession>
    <name>A0A0G4PEX9_PENC3</name>
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        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PCAMFM013_S013g000137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL24894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PEX9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PEX9"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195283" evidence="1">
        <location>
            <begin position="24"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL24894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="106" mass="11227" checksum="05F0717FB3B8AB8E" modified="2015-09-16" version="1">MVHLKSLLTLTLALATSITAINADSTCDDAYNKCVTAPGANLSTCFSDREACRHGQTNSPAKLHRERSVSDEDDCEDAFNKCRSAPGANISTCVSEKSACDNGGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PF00</accession>
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        <submittedName>
            <fullName evidence="8">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793146">
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    <dbReference type="STRING" id="1429867.A0A0G4PF00"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052780">
        <property type="entry name" value="AAA_Catabolism_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="34"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="72"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL24908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="735" mass="82285" checksum="3BDE05055A7D4707" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PF55</accession>
    <name>A0A0G4PF55_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ferric reductase-like transmembrane component, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S013g000153</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL24910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PF55"/>
    <dbReference type="STRING" id="1429867.A0A0G4PF55"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF12">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="12">
        <location>
            <begin position="307"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="386"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL24910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="619" mass="68346" checksum="70538BE38CD35417" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PF79</accession>
    <name>A0A0G4PF79_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S013g000232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL24989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PF79"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034595">
        <property type="entry name" value="NDUFAF8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34561">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34561:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL24989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="65" mass="7299" checksum="56F4A7DD0CDB6BD6" modified="2015-09-16" version="1">MPGRTRPVEKIAKASAQCSVEVAAYGKCVVADYNSVHKDMCAKEFMRLKNCYLVGDERLLRCSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PFR2</accession>
    <name>A0A0G4PFR2_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Palmitoyltransferase</fullName>
            <ecNumber evidence="13">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCAMFM013_S014g000033</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Palmitoyltransferase specific for casein kinase 1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="13"/>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PFR2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PFR2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <keyword evidence="2 5" id="KW-0694">RNA-binding</keyword>
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        <location>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="199"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="60"/>
            <end position="87"/>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="231"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="332"/>
            <end position="383"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="391"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL26160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="449" mass="48963" checksum="95779A42D2C86D45" modified="2015-09-16" version="1">MTDKLPPPLLALFQPRPPLRYLPPGDRAPDDCQKSTISGVAQFLADAKTFADEVPYNATESWVQRKLREKTEKKEQLEKQIAEGLQNYNPDKDPQARGDPFRTLFVGRLSYEAKEADLEREFGRFGPIERITIVKDTVSDKKKKPHRGYAFVVFEREKDMRGITTMPIYLALIPLVYSVLRIKGRPAVVDVERGRTTKGWKPRRFGGGLGGRGYTKALPPSRGGPFNAPSGPGGYGGGFRGGFGGRGGGGGFRGGGFRGGGDRFGGPRGGIGYQGNRGGFGGQAPPNAPSGPGGGRSGGFRGGSFGGDRGDRGGGAGGRFDRGATGSNSEPVRPRDSYADRDRRDYDRDDRYRDRDRDRMGDRGMGDRNGDRFRDRDRERGGDRYGGGSRDGGRDGGRDGGRDGGRDGGRDGGRDGGRDGGREDYGRKRNREDEPGYDDPRSRRRRRLS</sequence>
</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="P:aromatic amino acid family catabolic process"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
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    </dbReference>
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    </dbReference>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL26142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1030" mass="113801" checksum="C1627BBF98A68D85" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PK16</accession>
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        <submittedName>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
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            <end position="20"/>
        </location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="111" mass="11730" checksum="2C7FDF882054F72C" modified="2015-09-16" version="1">MRLFVQGTAILALLVANASAAKSGLFAANGVELEIYQSDEGIFYGEPRSLVQRDLEGRATNACTKCVGHHGSCVVGEGNCYAPDTCAFCGGCSVDQARCQNPDKEGCQCYK</sequence>
</entry>
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    <accession>A0A0G4PK98</accession>
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            <fullName evidence="3">UTP23 sensor motif region domain-containing protein</fullName>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">FM 013</strain>
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    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="UTP23_sensor"/>
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    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fcf1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF24779">
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    </dbReference>
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        <location>
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            <end position="261"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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    </feature>
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            <begin position="295"/>
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        </location>
    </feature>
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        <location>
            <begin position="310"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF24779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL26603.1"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="325" mass="36625" checksum="AEBC142C28556970" modified="2015-09-16" version="1">MRAKRSKKYRKLMHQYELTFGFREAYQVLVDSNFLRATDSFRMELIPALERTVQGKVKPLLTKCSLAAIMAAQPINPKTEKPYRPLFLPPPTELPLRHCSHNADSTPIDEIECLLSLLSPNADSKKNKEHYILACADPILRKANNSENQPRRRKTEEDRKEEEAMRRSHALRSAARSIPGVPIIYVKRSVMVLEPMSGPSEMVRDGHERGKFRAGLDVDPMLGKRKRDGEADGESADEAEPKKKRGPKVKAPNPLSVKKKKVDAPAPKKDKAVRKEVDVADATEQHDGEDTAAAKPKRKRRHAKSGPREDFEEAAEPNEAMEVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKG4</accession>
    <name>A0A0G4PKG4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Neuraminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S019g000246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKG4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PKG4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38792">
        <property type="entry name" value="BNR/ASP-BOX REPEAT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G06430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38792:SF3">
        <property type="entry name" value="BNR_ASP-BOX REPEAT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G06430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195625" evidence="1">
        <location>
            <begin position="26"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL26829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="579" mass="62822" checksum="A65D1328914958E2" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKJ4</accession>
    <name>A0A0G4PKJ4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA methylase, N-6 adenine-specific, conserved site</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S019g000125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKJ4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PKJ4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39614">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39614:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="3">
        <location>
            <begin position="42"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL26708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="399" mass="43618" checksum="7FFF451383742410" modified="2015-09-16" version="1">MAIKVPPGQSPPFETIDDKHHGGIIIITAAICLVISLVCLLIRVYVRIFLNPPWGSDDIILLGATISAIVESIIIFHAASIGFGTDISLLTEKAVGRIQNSLLGADILYLLTLYLSKCCIIAIYLRLTPRKRHKSILWATFGLSTAWIIMSVLIIAVNCQGNKPWVVPGEQCHNLFPRWQAIAALDISTEILLFTFCIALVWGLQMHISHKMVIMVSFAARLPLIIFSGLHLSTLKEYTTIRNPTFTAIRHTVFTQLHLNFALVACTVFCLRPFMNALTTHYGTAGDSNLGSSSGGYGYGYGSRPRGNTDPYTSGRSRDYEMGTVKERSGRRPSGLFKERPDVGDGTENGTVICEAAGPSHLGDVRSEGDRGSMRSGSDGSTKMIIRKDVEYSVSVGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKT0</accession>
    <name>A0A0G4PKT0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S020g000174</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="HG793153">
        <property type="protein sequence ID" value="CRL27015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKT0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PKT0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF37">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195635" description="Mannan endo-1,6-alpha-mannosidase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="395"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="398"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CRL27015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="452" mass="49793" checksum="104405EE401189E9" modified="2015-09-16" version="1">MSRWLATLLACLLIQNVTAIEVNPEDETSLKNAAKTVATTMMDFYNARDSKDIPGKMDDTWWEGGSMFMTLIQYWYLTGDSQFNDAIQEGMYWQKGENDFFPSNYSQYLGNDDQVFWGLAAITAGELNFPEREDEPSWVSLAEGVFNGQIPRWDMNNCGGGLRWQIWPYQDGYNLKNAISNGGLFQLSARLALYTKNATYAEWAEKIWDWSASTPLLRKTWVIADTTTNAASCKDHGDHQWTYNYATYISGAGYMHNYTNGTESKWLEGVTGLIKTSDQFFPASGGNQILSDITCEPINKCDRNQKTFKAYFTGWLGFISLIVPANVTADVMGKFKVSAVAAGQQCSGGSDGNHCGIRWTKKAEWDGTMGLEQQMSVLGVLNAVMFPFKTDGPYNADNGGTSKSDPHGGSNTKDSVGPGPITTGDRVGAGILTAFLVILWVGAVTFMLAGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKZ7</accession>
    <name>A0A0G4PKZ7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-dependent pyridine nucleotide-disulphide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S019g000243</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKZ7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PKZ7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF24">
        <property type="entry name" value="NUCLEOTIDE-DISULPHIDE OXIDOREDUCTASE AMID-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="2">
        <location>
            <begin position="14"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL26826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="417" mass="45916" checksum="FF198E5E612FA892" modified="2015-09-16" version="1">MPSNDFVRTVSRSFRVLVIGGSYGGLSAALALIDLSQGRLTRFNYNADAQAPTHRIPIQITVVDKRDGYYHLIGSPKALASEKFASEAWTRFQDIPGLKSPDLSFIQGSVSSVDFNAKEAHIVDADTKNSRTEPYDYLIASSGLRRSFPTVPQSLRREEFLKEAREHMADVKQAQDGIVIIGGGAVGVEMAAELKILYPEQKVTLVHSRKRLLSSEPLPDDFAERVDSILRDTGVEVILGQRVMDTTAVDTENGTRLWNLTLSDGRQIKTGHVLKAVSQTVPTSTYLPKEALNEEGYIKVHRSLQFSGAIPNPEHHWAVGDLTAWEGIKRCGGAMHMGHYAALNIHQHMMAECTGGKPEYQTLQPFPAVMGLALGKTAVSYTPGEGTREGEDLMKTLFGKDMGHTICWNYMRLGEAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PL71</accession>
    <name>A0A0G4PL71_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">von Willebrand factor, type A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S020g000057</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793153">
        <property type="protein sequence ID" value="CRL26898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PL71"/>
    <dbReference type="STRING" id="1429867.A0A0G4PL71"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013694">
        <property type="entry name" value="VIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737:SF6">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08487">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13768">
        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00609">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51468">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VIT" evidence="3">
        <location>
            <begin position="6"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="291"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="687"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="750"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL26898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="968" mass="106552" checksum="645B828E9E4D1DE0" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PLS9</accession>
    <name>A0A0G4PLS9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S022g000040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793155">
        <property type="protein sequence ID" value="CRL27360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PLS9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PLS9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL27360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="165" mass="18300" checksum="69AD21053B1D3EAC" modified="2015-09-16" version="1">MRAPNPKGQGDGGDGQAVEDGRGAVQWERFLAARSPCQLILQIPEVAQAVDRTLRSVRSSELENIPTSFKTSLHTQKQRSPHGWTQHRVKMTEASAKRLRATCIAIADQEAFQTGQLRLLYLNDQRNIVREVRLDHKSAGLTGLISHGYSMLGTSKTNLVEKIQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PLY0</accession>
    <name>A0A0G4PLY0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aromatic-ring hydroxylase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S022g000102</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793155">
        <property type="protein sequence ID" value="CRL27422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PLY0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PLY0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF317">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
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        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="6">
        <location>
            <begin position="9"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="84"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL27422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="389" mass="42720" checksum="4DB7A84B888DEAA3" modified="2015-09-16" version="1">MTVSNQPLDVLVIGAGIAGLSAAIALGKQGHRVVILEKSAFLKEAGAAIHLPPNCTALLRWMGIDPTDFGGTLLREEWYLVHRVELHNHLKQRALETATLYTQCRVTEVNLEGDCPSVTLDDGRTFKADVLLGADGLHSQIRRSIAPESPSPYPVGKSCFRWLLPTDQLRHHASTADFVRETGVFIECGSGDRRLVAYPCSDSKILNICAFVPLNEVQADDESDSWQAAGDKTTIVKAFSKFSPGVQQIIASADKNLKVWDLYDMEALPTWTRGHAALLGDAAHPFQPYMGQGAAMAIEDAVSIATLLPHGSTPHDIPMRLDLYQTARRPRVDFVLHHTRVNGRNENDAAGDRLSGAEMGKIMNICFSHNEIEHSTSLLDGKLTDKWRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMM3</accession>
    <name>A0A0G4PMM3_PENC3</name>
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        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S023g000155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793156">
        <property type="protein sequence ID" value="CRL27697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PMM3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL27697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="64" mass="7137" checksum="9F98434A60B3244C" modified="2015-09-16" version="1">MRFLSVRHPVAFYSKVISPFGKYTLSLTKYTTERMAINPSKLEVNAISSFVNTIIEKAAVGPCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNM7</accession>
    <name>A0A0G4PNM7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S025g000037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793158">
        <property type="protein sequence ID" value="CRL27979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PNM7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL27979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="122" mass="13654" checksum="1B9BEBB1E5292AB4" modified="2015-09-16" version="1">MYNTQKFLQVLSFPRKLSPLSISGCELQLFRPCYTTPSLHYSSTCFTPNIPGTVISNSAWVQTRPATNKKVDTSPQFLARHTTGDVLLNPHTRDPPPPPPPPPPPPIPSPIPYNKMENYPWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PP19</accession>
    <name>A0A0G4PP19_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ER lumen protein-retaining receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S024g000193</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ERD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG793157">
        <property type="protein sequence ID" value="CRL27938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PP19"/>
    <dbReference type="STRING" id="1429867.A0A0G4PP19"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00951">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00952">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10 11 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL27938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="217" mass="25422" checksum="DEA866C317AB33F6" modified="2015-09-16" version="1">MNLFRLLADFSHLASIFMLLQKMKTSSSCSGLSFKSQVLYLLVFVTRYLDLFWTFTDSLYLTTFKLLFIGSSAYVIYLMLNDYKPTHDPNIDTFKVQYLLGISAVLAILFPRDYRISEILWTFSIWLESVAILPQLFMLQRTGEADTITTHYLFALGLYRALYIPNWVFRYFTEASFQRSFQPVTIIAGIIQTLLYSDFFYIYYNKVLKGKKFSLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PP29</accession>
    <name>A0A0G4PP29_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycoside hydrolase, family 61</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S026g000010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793159">
        <property type="protein sequence ID" value="CRL28145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PP29"/>
    <dbReference type="STRING" id="1429867.A0A0G4PP29"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
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        </location>
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        <source>
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        <source>
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    <sequence length="451" mass="45662" checksum="A1A6D4D49B598CFE" modified="2015-09-16" version="1">MSISKITGLLLSSAAMVAGHGYVSGAVVDGTYHGGFLVNTYNYMEEVPANIGWAEKATDLGFIDGSGYASSDIICHKEATPGAISAEVKAGGEVELQWTEWPESHHGPVITYMANCNGDCSKVDKTTLKFFKIAEAGLIDDSNVPGKWATDELIANNNSATVTIPSAIAAGNYVLRHEIIGLHSAGEENGAQNYPQCLNLKVTGGGSDVPEGVLGTALYKATDPGIKISIYTALDSYEIPGPALYTGAASGSSSGSATTTAAATTAPATTAAPTAASTVSASPIQSSSRHFTRTRTFTPSGTPTPSSAPSSAYESTEAPSTATETATFTEAATSIETATSTVSSAPQVTDEPDTQTASSADSVSITSTASGQSAQSTTPVSGGDDSESSSSASATATAAPTAAASSSASASSGDYSSYLSSLSAEKLLEAIRSTLKWLVSDSKVHARALAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PP97</accession>
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        <name evidence="8" type="ORF">PCAMFM013_S024g000196</name>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
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                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">FM 013</strain>
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        </subcellularLocation>
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        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS33 family.</text>
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    </dbReference>
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        <source>
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    </evidence>
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            <dbReference type="EMBL" id="CRL27941.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="106" mass="12187" checksum="33151FA68E1BF6E4" modified="2015-09-16" version="1">MASSRILDLVKTQCRIFSLNFNPQRLRLGNKVLRQRLRGPALAAWYPKQTVSFQDLQNTYKPLGLTTFDEAEDDREEAIQIAKLRGKGRPKKKRTAAESRSAKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
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    <name>A0A0G4PPI1_PENC3</name>
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        <submittedName>
            <fullName evidence="6">Nucleotide-binding, alpha-beta plait</fullName>
        </submittedName>
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        <name evidence="6" type="ORF">PCAMFM013_S026g000170</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
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            <taxon>Eurotiales</taxon>
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    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
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                <person name="Lacoste S."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="RNA-binding domain, RBD"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
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    </feature>
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        <location>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL28305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="631" mass="69417" checksum="363EF0F661551640" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPU4</accession>
    <name>A0A0G4PPU4_PENC3</name>
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        <submittedName>
            <fullName evidence="7">Ras small GTPase, Ras type</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">PCAMFM013_S026g000046</name>
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        </lineage>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793159">
        <property type="protein sequence ID" value="CRL28181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PPU4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Spg1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Septum-promoting GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
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        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
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        <location>
            <begin position="98"/>
            <end position="176"/>
        </location>
    </feature>
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        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
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        <location>
            <begin position="37"/>
            <end position="70"/>
        </location>
    </feature>
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        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
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        <location>
            <begin position="161"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL28181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="370" mass="41237" checksum="0D0D8C3581979C53" modified="2015-09-16" version="1">MEFHKPNWEPLVAPEVEAPAVPVVAESEKIAPEDQMEQAQEQAHGQGQEIPPEQPLEQPAEQPLDQPLEQSAPVMVNIEEPASDHTISRAAINTGYNSDSKAHYHSRSTEFHQSAPEYAAQDTDQSRQNSSPLLNHHPLPVPNSRPGSGLSSGPERAPGVSQLQQQDASQRQASQANKNSVVIKVGMVGDAQIGKTSLMVKYVEGSWDEDYIQTLGVNFMEKTISIRNTEITFSIWDLGGQREFVNMLPLVCNDAVAILFMFDLTRKSTLNSIKEWYRQGRGFNKTAIPFLVGTKYDHFVNFPREDQEEISIQAKRFAKAMKASLIFSSTSHSINVQKIFKIVLAKAFDLKCTIPEIENVGEPLLLYKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPX6</accession>
    <name>A0A0G4PPX6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S026g000081</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CRL28216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
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    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="518"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL28216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="572" mass="64897" checksum="620FC7604BC6B024" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-11-27" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQD3</accession>
    <name>A0A0G4PQD3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Trimeric LpxA-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S029g000021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793162">
        <property type="protein sequence ID" value="CRL28605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQD3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PQD3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051159">
        <property type="entry name" value="Hexapeptide_acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416:SF54">
        <property type="entry name" value="ACETYLTRANSFERASE, CYSE_LACA_LPXA_NODL FAMILY (AFU_ORTHOLOGUE AFUA_2G08430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416">
        <property type="entry name" value="SIALIC ACID SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL28605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="128" mass="14293" checksum="D47AB9AEE971BDC4" modified="2015-09-16" version="1">MPPLNPDLKEDEEIFEEADPFVDRPIFVAHGLNFKVGKGTFLKSNLRVLDTCLITIGERVLLGPDVYLYSATHPVDPAVRQGLKGPECGKEVHIEDDVEDVTPFHFVAGNPARVIRRIETSITPDEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQI1</accession>
    <name>A0A0G4PQI1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S027g000070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793160">
        <property type="protein sequence ID" value="CRL28381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQI1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PQI1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056929">
        <property type="entry name" value="Znf_RING-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25080">
        <property type="entry name" value="zf_RING-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RING zinc finger-like" evidence="2">
        <location>
            <begin position="426"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL28381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="509" mass="55924" checksum="489D9960750506FB" modified="2015-09-16" version="1">MPPRSSLTSSFSVTDANNEVVCPLKNNDNSNCRKRCLGEKRYRSMQEHIRRAHPNHYIPKLPATEESFLMMVNTPLEQRVQLSPPEPAQPRRPHDVAPERDIYVADGSPATPRALDEPHPAAATAAVALAQLHHHRLASDWDTDMDTHSDTDLSHPRLRGAIELPPLRDHFKQESLPPFTPRPRELLPSILNHSPPGRSSTLPPIQRRDKFCRPRKSSITQSARKPKQDRPKSKEFGRRPSLGDRKALSAEPQTAAWAQGKRWEDLIEAATSATEVDDEPYSEAGRSPTIAPLLSNVTSAPSGVKNRSSLPPAFQSAGLPPISSHRPFPPHSYAASPLHKSLTPPPYENHRGRESDLEPFPSIESSLDSMSSASGRNFASSVSGVAPSINSDSSPVMNLIPSISQRQQHRFSNPTPASFRNKEVQVFCAQCKRPSALNECYACTECICGVCRDCVGMFISSPPASFRTPGNGPLNNASSQGPTSYPGPRGCPRCRTVGGKWKAFQIDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQV0</accession>
    <name>A0A0G4PQV0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S030g000071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793163">
        <property type="protein sequence ID" value="CRL28784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQV0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PQV0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL28784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="95" mass="10376" checksum="F53F94B9B387317D" modified="2015-09-16" version="1">MTEQVGKGMALETSIFRLDSVCPRMLDLCMAPGGFTTTAAKEAPALFIDAVTLPIEIGGYEVMAKDICQNIIYSDITMYLMEWPGLPRQHSDGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQX4</accession>
    <name>A0A0G4PQX4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S028g000121</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793161">
        <property type="protein sequence ID" value="CRL28568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQX4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF103">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL28568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="524" mass="57212" checksum="7FC6F3E880B834DC" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PR35</accession>
    <name>A0A0G4PR35_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase, family 43</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S031g000042</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793164">
        <property type="protein sequence ID" value="CRL28874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PR35"/>
    <dbReference type="STRING" id="1429867.A0A0G4PR35"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18619">
        <property type="entry name" value="GH43_CoXyl43_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052176">
        <property type="entry name" value="Glycosyl_Hydrlase_43_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43772:SF5">
        <property type="entry name" value="BETA-1,4-XYLOSIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43772">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL28874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="355" mass="39899" checksum="1E9F5836A9AA6636" modified="2015-09-16" version="1">MSKPLVSHIYTADPSAHVFNNKLYIYPSHDRETTIPFNDNGDQYDMADYHVLSMDTITSPVTDHGVVLRDKDIPWVSKQLWAPDAATKNNKFYLFFPARDQKGIFRIGVAVADAPEGPFVPQEDYIQGTYSIDPAVFVDEEVGGEAYLYVGGIWGGQLQCWVEGKDEDNGEGEWVDGDEGGVDGRKKRLVFNESLSGPHEPAGEGVRALCPRVALLKDDMLSLASSVKEVVILAPETGEPLLADDHERRFFEAAWVHRYQGTYYFSYSTGDTHFLAYATGSSPWGPFTYRGHILDPVLGWTTHHSIVEFQGKWYLFYHDCELSEGVDHLRSVKVREIVYDDEGAIHLAEEQTPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRH5</accession>
    <name>A0A0G4PRH5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S030g000008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793163">
        <property type="protein sequence ID" value="CRL28721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PRH5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL28721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="73" mass="8054" checksum="B698A57499BF8F3D" modified="2015-09-16" version="1">MIVRSCRDRTASSESPFVAAASPLLELRLKKVCESKVLATWNGDYAKGTMSGKLRGIKSHADMRIMQTARRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PSB5</accession>
    <name>A0A0G4PSB5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Taurine catabolism dioxygenase TauD/TfdA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S034g000098</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793167">
        <property type="protein sequence ID" value="CRL29300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PSB5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PSB5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051178">
        <property type="entry name" value="TfdA_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779:SF2">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT XANTHINE DIOXYGENASE XAN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779">
        <property type="entry name" value="DIOXYGENASE RV0097-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="21"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL29300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="404" mass="45932" checksum="AD3DE4F6AE259CD0" modified="2015-09-16" version="1">MPESASLTFNLLPDEIRQSSAIGAEVQLPPGMVMLDLDRLTDNDKDTLRKALFENQVVVIRKQKGIDPTVLPKLAKIFDPNASDIHSAGEKAVSDPKNILSAYKAGRIPRAPQVGIIGSGKFQDYEGLKDLEVVHLDHTLFHEEPLSQEELDDGYTRPYRWHMDTPFYERLPGEVTILHSIRIPNVPDQKIKFPDGKEKSIGAGATAFFSGARIFSLLTPEEQEFALNTTVTYAPQAYEYIRQCKASEDGLTIPNFGREIPVEKLSEWAWDKVAEHPMVWRNPLNPDRPFFQVHGCCVYKLTTRNPATGEITVMDDVEEVREVVYKMQSKIYAVENIYAHHWQEGDVVIFHNRGVMHSITGQLAKYKEQEDKRRLLWQCTMTSTTPPKPFRDYEGVNDTGYARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PSM7</accession>
    <name>A0A0G4PSM7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S033g000076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793166">
        <property type="protein sequence ID" value="CRL29156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PSM7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1020">
        <property type="entry name" value="Prion-inhibition and propagation, HeLo domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056002">
        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029498">
        <property type="entry name" value="HeLo_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038305">
        <property type="entry name" value="HeLo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF1">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14479">
        <property type="entry name" value="HeLo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="287"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL29156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="639" mass="72682" checksum="2FF7EE525AB63E35" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PTQ3</accession>
    <name>A0A0G4PTQ3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S039g000045</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793172">
        <property type="protein sequence ID" value="CRL29736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PTQ3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PTQ3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF52">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="79"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL29736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="537" mass="58516" checksum="FAB92722B47FB98F" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PU79</accession>
    <name>A0A0G4PU79_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S039g000026</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793172">
        <property type="protein sequence ID" value="CRL29717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PU79"/>
    <dbReference type="STRING" id="1429867.A0A0G4PU79"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15853">
        <property type="entry name" value="SNARE_Bet1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039899">
        <property type="entry name" value="BET1_SNARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL29717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="97" mass="10550" checksum="DE3196C8B146847C" modified="2015-09-16" version="1">MSDAYEREQQNNALLNSLSSKVSALRSVTIDIHDNARDQDTLDHTSDVFSSFSTNLKGSATRLTRMAKQGDSVAVLKIAGMCIAAGIALYIILGWIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-11-27" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUD6</accession>
    <name>A0A0G4PUD6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exocyst complex component SEC15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S044g000051</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the SEC15 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793177">
        <property type="protein sequence ID" value="CRL30120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PUD6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PUD6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.30:FF:000004">
        <property type="entry name" value="Exocyst complex component SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.670:FF:000004">
        <property type="entry name" value="Exocyst complex component SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.670">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.30">
        <property type="entry name" value="Exocyst complex subunit Sec15 C-terminal domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007225">
        <property type="entry name" value="EXOC6/Sec15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046361">
        <property type="entry name" value="EXOC6/Sec15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042045">
        <property type="entry name" value="EXOC6/Sec15_C_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048359">
        <property type="entry name" value="EXOC6_Sec15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702">
        <property type="entry name" value="SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20651">
        <property type="entry name" value="EXOC6_Sec15_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04091">
        <property type="entry name" value="Sec15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025007">
        <property type="entry name" value="Sec15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC6/Sec15 N-terminal" evidence="7">
        <location>
            <begin position="50"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex subunit EXOC6/Sec15 C-terminal" evidence="6">
        <location>
            <begin position="401"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR025007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL30120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="766" mass="87608" checksum="DBD6473A52E7E013" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVK2</accession>
    <name>A0A0G4PVK2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S051g000021</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793184">
        <property type="protein sequence ID" value="CRL30418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PVK2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PVK2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF24">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL30418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="499" mass="57100" checksum="374F33BAE57711CB" modified="2015-09-16" version="1">MFQLNINLPLTLEVLEFEEEMTSPTSQSRVPKACDPCNRRKVRCNGQQRCQQCEHLDLMCTYTENRLLRSRKHSLRRGAVISKYKSANPKTTTLTPLLSPPTASASPQLPTSYFESLLPAYMSYVYPFSPIITETEVRESLIKMNTEREHAAFIYAFTAVTLDLTRSSQFTTKSNPQPASTQITDLMRQSVETQEPLVIGFRPSILRATTSIFIQMCAMSLGHSDLGFFHLREAISMIQMLRISDKTVNASLTTAERARRQRLYWQCFIHERFMSIVNFSPVTLPPHTQYPEEDTTLGTEIQQGWTQVIKTFCMLDASFISLWIGDRTQVTASWVERKHRELDDALWEVEVSALSELQQADLVITRQWMRTLLWQMAMSNCLLSSHASCPSLELEMPLILSSQLRQFLTKISQNTIRVHGSSMISKLLEIVNTIADVVIHVPQATREETTSRIDDIVFMQGVVLSFHNLQVMPKDILLDKFRVIRGRFPHIEVAMKLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVL9</accession>
    <name>A0A0G4PVL9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S048g000063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793181">
        <property type="protein sequence ID" value="CRL30351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PVL9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="476" mass="52582" checksum="84E0F719B93EDCF4" modified="2015-09-16" version="1">MASSGGVNKISTGNTKGKKSHLPEMLERDKEGHLPPGFMERVAAQASISQGRHPPDNPADTYDGGQLDDNGPIDQANSSPPSDSSVVKSIERDDTPMHDAGTGSRSSGHERPPAAGHSQNQDDLSPSTRGTTEPEEPELLATLDPSNDEEESDALVDGWGTLRGSTFVILQYGPRHGARYKFKYRHGYTNEFMNSMSESSLRISQIKVSPGSKNWRYSKNNVVGIYGIASEERKNPNKKYKSDPCTWLKIKWKDLRSEDTDKTQNFCSWIPRSDFIRFCNGKRAADAKIKEVWDKQEERYQRVLQSDTGRGSEDRSPTPCPLGSAARQSLEREHTQRLSSPATQFVSAGQYEIPPSTAQLRPRQGSSTNPINLDEDEAAQNPVSSGAALNSNTNAVQNKSNLAIGQRAIRTEAEFIAEREKDEGWHDLDDIQRETRLTVAKAMYDLYRDTIAQNMQPQGSVNTPIGERPGVAVAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PW25</accession>
    <name>A0A0G4PW25_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S057g000033</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793190">
        <property type="protein sequence ID" value="CRL30711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PW25"/>
    <dbReference type="STRING" id="1429867.A0A0G4PW25"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057722">
        <property type="entry name" value="AsqO/PenF-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25581">
        <property type="entry name" value="AsqO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="AsqO/PenF-like C-terminal" evidence="2">
        <location>
            <begin position="183"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL30711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="269" mass="29254" checksum="442FD23B5F573208" modified="2015-09-16" version="1">MSMSYGIQASSLAVTYSGDEDLGIFSRWQDLSKDAEGSAKILNLVWTNVAANAVTGTRGWHTQAASANSADDENAGGTFVRKFNRRIHYRWAYGIPAFIVLLLTLLATVISLLLFVLGRGTPFSVKWYLNSTSMGRVYGQFIYPDTSVVQLPTEEWIGQVGVTKVRLGEVAGVNQELVLLHFAVKVRRVRSNATYPPTGGIMESPGLTARFILGGGQVFAINLTKQAIVHHEIVYARALGSVAGGIEGRAVYSGRVHYEGYAYGLLFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PX76</accession>
    <name>A0A0G4PX76_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S063g000019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793196">
        <property type="protein sequence ID" value="CRL30913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PX76"/>
    <dbReference type="STRING" id="1429867.A0A0G4PX76"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="116" mass="13189" checksum="F9B15E1273F3E5A9" modified="2015-09-16" version="1">MERPTWAQRRRNTRGSLAWFPLSEALKTINLGRLQEIEMIDPTPLPPCIQVQVGPLERWSFHTAGLSGILYAINIINMIDLRHWRTSHTEVDSATTLSDSKSTLQAVQNPRNKLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PXI7</accession>
    <name>A0A0G4PXI7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S094g000003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793225">
        <property type="protein sequence ID" value="CRL31234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PXI7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL31234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="72" mass="8618" checksum="50CA1C202F6DDE63" modified="2015-09-16" version="1">MSTLGVKHFKFGYNFTLADRLLEPSTKAYIWKYLFRVIGRQRFFYSKTLSVENVYMIRETTGKRLMRLSKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PXQ3</accession>
    <name>A0A0G4PXQ3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S076g000011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793208">
        <property type="protein sequence ID" value="CRL31118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PXQ3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PXQ3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL31118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="501" mass="57411" checksum="F778E246829B870F" modified="2015-09-16" version="1">MSLLSTFGRKRPAIVPTDRIIPLRYWDDLDYLRSICHAFTLRFDDTLDVIKLETALLRLMEIGDWGQMGARLRLNNHGKLEYHIPECYDERRPAFIFTTTTYDMSITDHPLGSQMPKAGQDQSFLSPSSDFFTSIVCHPDSPRELADWIYTDRPQLHIHVALFQDATLLTINYLHTFVDAISRTNFFDAWIAVLRGQEEEEVPAFLPYDHDPLCTLGKEAPRQSYSNIGRLLSGLSLVIFGLRYMFEILWVQNLEEHPIRLPGRCVDRMRKTVLQELAVTAPRGAKKPFVSEGDVVVAWWVRTMTKALKPAPDRTIMVMNVFNVWDLFPEWFPNGAAGLIGNSFFYSYTLLVARNVLQDINLSYVASTNRKALVEHRTKQQVEAMTAIQRGNFMRAAPVVGDPKMLFMAATNQHKARYFETDWSEAVIAPGVPLSGRPHALGRPSYINDIEYCRGYPTRNIVRIIGKDAAGDWHLLFKTRAGAWPVIHQELMNLIETEMWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PYD3</accession>
    <name>A0A0G4PYD3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S121g000002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793252">
        <property type="protein sequence ID" value="CRL31334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PYD3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL31334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="77" mass="8648" checksum="D805D736D65CEBDD" modified="2015-09-16" version="1">MDSSCAMHCWRCLEDYSQTILAHTQSQIAMLVGLDGSQGVRNDIDDNTGSDMLEFQEPSLHKLERRNCSPTETQTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PYE7</accession>
    <name>A0A0G4PYE7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S092g000003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793223">
        <property type="protein sequence ID" value="CRL31228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PYE7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL31228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="83" mass="9835" checksum="46A2B3CC79F0D0A0" modified="2015-09-16" version="1">MSEAQSQHPVKGKEPFIERIFEHHHHHNHEEDSPADKKDGTSNNKDKPKSYEDYLKKDEEALKEYYEKDKEMEAEDQTYGGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PZ80</accession>
    <name>A0A0G4PZ80_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-directed DNA polymerase (Reverse transcriptase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S3Jg000071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793312">
        <property type="protein sequence ID" value="CRL31460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PZ80"/>
    <dbReference type="STRING" id="1429867.A0A0G4PZ80"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="32"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL31460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="181" mass="20881" checksum="2BAF5D4054A04C95" modified="2015-09-16" version="1">MWLLWKERTQRRRPQGEKLQQQSQEQVNSWLTNKVIEPIKTPALTNNLALVSKKDGRVRVCVDCTPANEVTKDFDWHLPRLQDVRYRTQGKSWFARIDLEDAFFRIGVPARSRQLTAFTVGGQTYKFRRMPLGLKTAPAVFQRFMDHGLSEFADAIWYIDDILITATSGQNSAEGNALHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NSY3</accession>
    <name>A0A0G4NSY3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S001g000141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NSY3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL17181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="39" mass="4628" checksum="E6F98EBB62EAC99D" modified="2015-09-16" version="1">MRGGSDHRSHIRDWYFIANIFEDIPRMAFRTGEGSAPWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NUQ6</accession>
    <name>A0A0G4NUQ6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S001g000766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NUQ6"/>
    <dbReference type="STRING" id="1429867.A0A0G4NUQ6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL17806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="199" mass="21010" checksum="99A7497E195DC2D9" modified="2015-09-16" version="1">MASSSAPVQSAASDRDTAQLVKEHSHAFQNRLNTTQTDSPPVSETTKSDIDTDQLKAEAGLEAPKPAPETKPPVTEPTEPAPGSVPIARQSQISVGPKDETVAGEKRDIDSTVTPTPALAEDEEQQRPEPSDEPDTKKLKTDEKPVSDPNGTAAAPSNTENGAQKKASRSKKEKIKDAVNKVIPGDGIGSRTRSRTKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NVE9</accession>
    <name>A0A0G4NVE9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S001g000985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL18025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NVE9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL18025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="84" mass="9329" checksum="C74CF0CC86B990AA" modified="2015-09-16" version="1">MSSLGEAKDVDLSVEDEVSSRRGYTAVLTSSKVSKKAKRNALDLLNDELDGDTPRHYLDEAPDQSKDQERADRKSQDNTLSESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NVT0</accession>
    <name>A0A0G4NVT0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glucosamine 6-phosphate N-acetyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S002g000032</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 8">
            <text>D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="2.3.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the acetyltransferase family. GNA1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.4" evidence="8"/>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NVT0"/>
    <dbReference type="STRING" id="1429867.A0A0G4NVT0"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000048">
        <property type="entry name" value="Glucosamine 6-phosphate N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355:SF11">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="9">
        <location>
            <begin position="56"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL18162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="198" mass="22046" checksum="7159E397366209EC" modified="2015-09-16" version="1">MTAHALASNTVPEATKPIMSSTVTQVDASVDPVTDGPLFPSTLISPEVISLLPTDYTIRPMRRSDYNRGYLDVLRVLTTVGDITEEAWNQRYDWITSRNDEYYMLVVCDGADRVVGTGSLIVERKFIHSLGMVGHIEDIAVEKNQQGKKLGLRIIQALDFVAAQVGCYKSILDCSEVNEGFYVKCGFKRAGLEMAHYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NW82</accession>
    <name>A0A0G4NW82_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S002g000212</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NW82"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL18342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="87" mass="9853" checksum="E19345800B4A7200" modified="2015-09-16" version="1">MPLNILLSWDRAKGIAMALEHGYPMKPFSMQEILNRDGISNAACKPRNPETYLMGLCLSIVATLPWLYCHDALFPLERLNASKDIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWI3</accession>
    <name>A0A0G4NWI3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphomethylpyrimidine kinase type-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S002g000318</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWI3"/>
    <dbReference type="STRING" id="1429867.A0A0G4NWI3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008902">
        <property type="term" value="F:hydroxymethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050334">
        <property type="term" value="F:thiaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19367">
        <property type="entry name" value="TenA_C_ScTHI20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.910.10:FF:000003">
        <property type="entry name" value="Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000034">
        <property type="entry name" value="Putative hydroxymethylpyrimidine/ phosphomethylpyrimidine kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027574">
        <property type="entry name" value="Thiaminase_II"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04306">
        <property type="entry name" value="salvage_TenA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858:SF17">
        <property type="entry name" value="HYDROXYMETHYLPYRIMIDINE_PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PHOSPHOMETHYLPYRIMIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Thiaminase-2/PQQC" evidence="1">
        <location>
            <begin position="299"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL18448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="529" mass="57733" checksum="97CB73F4B12BEE5A" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWS3</accession>
    <name>A0A0G4NWS3_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S002g000376</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWS3"/>
    <dbReference type="STRING" id="1429867.A0A0G4NWS3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000044">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="7">
        <location>
            <begin position="18"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL18506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="732" mass="80986" checksum="93C8231BF944CB0E" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NX76</accession>
    <name>A0A0G4NX76_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S002g000593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NX76"/>
    <dbReference type="STRING" id="1429867.A0A0G4NX76"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL18723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="105" mass="11584" checksum="0278279CF9B7E4DE" modified="2015-09-16" version="1">MVNKMGKLSSTSSTSTAGTLRPTSYANTNSCNPAIYRVVLFDQCGAGRSMPAAELRTNKCQHLVSDIEVLGWLLFNTHHLYAAREAVSFLPQTPKTTRKTDYCKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXG6</accession>
    <name>A0A0G4NXG6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rossmann-like alpha/beta/alpha sandwich fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S002g000605</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>beta-nicotinamide D-ribonucleotide + ATP + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NXG6"/>
    <dbReference type="STRING" id="1429867.A0A0G4NXG6"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02165">
        <property type="entry name" value="NMNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31285">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31285:SF0">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL18735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="290" mass="32706" checksum="CFB6BD37D6059057" modified="2015-09-16" version="1">MSSFRALQAQYGVLLKRFLNSNKDFEVLTTIPPDHSAESETLYVLDSSFNPPTRAHLRIVSTALIENPQPRPRVLLLLATQNADKPSKPASFEDRLVMMELFARDLRAHLASAPAFAASGITNSVETLPLIDIGVTKMPYFVDKATAIEASDSYPVPLEQVHLTGYDTLIRIFDSKYYAPEHTLKPLEPFLSKHRLRVTMRPSDEWGGREEQLEYVAALARGDRDGEGARREWADRIQLVEGRLSSDRPVSSTRAREALQSAPQDLNWLVPEQVRQFVLSERPYSGNSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXP2</accession>
    <name>A0A0G4NXP2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Helicase, superfamily 1/2, ATP-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S002g000624</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NXP2"/>
    <dbReference type="STRING" id="1429867.A0A0G4NXP2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18024">
        <property type="entry name" value="DEXHc_Mtr4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13154">
        <property type="entry name" value="KOW_Mtr4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000003">
        <property type="entry name" value="ATP dependent RNA helicase (Dob1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000083">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000141">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.300:FF:000001">
        <property type="entry name" value="Mtr4 exosome RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="168"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="407"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL18754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1081" mass="121805" checksum="19F5C36F9C4B5EDA" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-11-27" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXP6</accession>
    <name>A0A0G4NXP6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b-c1 complex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S002g000700</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the UQCRB/QCR7 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NXP6"/>
    <dbReference type="STRING" id="1429867.A0A0G4NXP6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1090.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1090.10">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003197">
        <property type="entry name" value="QCR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036544">
        <property type="entry name" value="QCR7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02271">
        <property type="entry name" value="UCR_14kD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000022">
        <property type="entry name" value="Bc1_14K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81524">
        <property type="entry name" value="14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL18830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="122" mass="14296" checksum="F5B722FD169EB080" modified="2015-09-16" version="1">MSAPSLASYIVKRPWLKSWLTPLSHWYTDAAGYRRLGLKFDDLIPEESENVQKAIKRLPAKEAYDRVFRIRRAFQCSISHTLLPANEQIKPEEDVEYLSPIIREIEKEVKERADLDNLVVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYF3</accession>
    <name>A0A0G4NYF3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S002g000968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL19098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NYF3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL19098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="91" mass="9833" checksum="BBF8185AB0077128" modified="2015-09-16" version="1">MESFVTARCSVRWTGARGGSVEQGSIPPVTIRVNPIFLDPAQAMSDNPRAHSLGPGLSPAEFREEISTHTPPQPRQIRSMEDGVTCVMGID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYN6</accession>
    <name>A0A0G4NYN6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EKC/KEOPS complex subunit GON7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S002g001036</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely plays a supporting role to the catalytic subunit KAE1 in the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GON7 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL19166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NYN6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014849">
        <property type="entry name" value="EKC/KEOPS_Gon7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08738">
        <property type="entry name" value="Gon7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0779">Telomere</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CRL19166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="90" mass="9929" checksum="4D3330478B1069DF" modified="2015-09-16" version="1">MASNTSLNAVYTAPQSTETFEHVISTTTGTLADKQAHLSALQSLVPKLQDQINVFLTERMEEDKKVQGQISAQEAKEEENYGEEVVEDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZN9</accession>
    <name>A0A0G4NZN9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S003g000332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZN9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL19541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="53" mass="5824" checksum="05409A25EDF427FB" modified="2015-09-16" version="1">MFTANATESKGLTSAITAEVGPKTRNHNITAPGRTENFWKRHFRNGDGHGDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZT5</accession>
    <name>A0A0G4NZT5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Adenylyl-sulfate kinase</fullName>
            <ecNumber evidence="4 11">2.7.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S003g000371</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the APS kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="4 11"/>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZT5"/>
    <dbReference type="STRING" id="1429867.A0A0G4NZT5"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000212">
        <property type="entry name" value="Adenylyl-sulfate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003013">
        <property type="entry name" value="PRK03846.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055">
        <property type="entry name" value="BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055:SF1">
        <property type="entry name" value="PAPS SYNTHETASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="8 11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APS kinase" evidence="12">
        <location>
            <begin position="21"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL19580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="208" mass="23300" checksum="AB7A18ACEBBD3219" modified="2015-09-16" version="1">MSTFHASALTRSERTELRNQQGLTIWLTGLSASGKSTLAVELEHQLVRDRGVHAYRLDGDNIRFGLNKDLGFSEADRNENIRRIAEVAKLFADSNSIAITSFISPYRKDRDTARQLHEAVTPGEETGLPFVEVYVDVPVEVAEQRDPKGLYKKAREGVIKEFTGISAPYEAPANPEVHVKNYELPVQDAVKQIIDYLDSKGYLPAKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0A6</accession>
    <name>A0A0G4P0A6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc finger, MYND-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S003g000514</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P0A6"/>
    <dbReference type="STRING" id="1429867.A0A0G4P0A6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="179"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL19723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="232" mass="26299" checksum="BD6EF8D0AAAB45DF" modified="2015-09-16" version="1">MGRWGWRLFEGDQDLDAVLSISDDTLGIKTGQWDFRLSAMVHQSDMLAPPEAAAVYRTAEYAHELANVIVPYVRRKLDTGNLGERMFAASRAKESDPDDLFQESKYRTIIMGALIMRAGARISAADLQHLRDLVPQINCTSRRTLLDDHGFRSPGRAQFLAALDHYQPGVARSFQEPSCFKCGKIEEDIGRKPLQCKKCKVATYCSKDCQRDQWREHRVSCIPPGQRRVLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0P1</accession>
    <name>A0A0G4P0P1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">MICOS complex subunit MIC12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Altered inheritance of mitochondria protein 5, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Found in mitochondrial proteome protein 51</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S003g000635</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the MICOS complex subunit Mic12 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P0P1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044284">
        <property type="term" value="C:mitochondrial crista junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031463">
        <property type="entry name" value="Mic12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17050">
        <property type="entry name" value="AIM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL19843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="125" mass="14575" checksum="522BCEA0388D802A" modified="2015-09-16" version="1">MGFFTGFFGGFVFTSSVLYITVQVHRSTRISQRKAIHAQVEQIDWLTSSAGAYDRRFLPEDLTRQRREELEAQNQPAPTMKEILKHQWNKEVEVLTRKAHETRWEDVRDAAAEGWKAAARVVKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0R7</accession>
    <name>A0A0G4P0R7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S003g000698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P0R7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL19906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="87" mass="9986" checksum="62B96AEDA4E4FB45" modified="2015-09-16" version="1">MDGQDEAQKDDDQTKEQTYNDDADDDTEIEGQDSNNNNNNMNDEGKEGQKQGSSSWTVSPCTHCLLPKWTCVPYWNGPWTFQVLFFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P131</accession>
    <name>A0A0G4P131_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S003g000817</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL20025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P131"/>
    <dbReference type="STRING" id="1429867.A0A0G4P131"/>
    <dbReference type="ESTHER" id="penca-a0a0g4p131">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000213">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005118195" description="Carboxylic ester hydrolase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="9">
        <location>
            <begin position="46"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL20025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="567" mass="61947" checksum="CFEA9CFAE314334D" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P1Q5</accession>
    <name>A0A0G4P1Q5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase superfamily, zinc-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S004g000159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P1Q5"/>
    <dbReference type="STRING" id="1429867.A0A0G4P1Q5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C1773.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="13"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL20219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="341" mass="36475" checksum="ACA402A830C8B695" modified="2015-09-16" version="1">MSQMETVRIVQAGDKFTAEPRDESRPVPGPRDVLIKVYAASLNYRDTALLRGEYRAPTKENGIPLSDGAGEVIAVGKDVVRIRKGDRVAVSCVTNWIGGPYSPEYRSSSVGFTVDGLLAECVVFNEDALARIPDYMSYVEAASLPCAAVTAWTALNKVEPLQPGQTVLIQGTGGVSLFALQFAKIFGARVLAITSSDGKAAKLKELGVDAVVNYSNTPDWDREILALTGGKGVDKVLDIAGEKTIVKSAASTRITGTVVLIGFASGFGGGLPPIDILVRSLTVTGSTVGSRIEFEAMLQAMERHQVKPIIDQVFPFAEFHKAYERLESGQQVGKVVIEIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P244</accession>
    <name>A0A0G4P244_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phytanoyl-CoA dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S004g000319</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P244"/>
    <dbReference type="STRING" id="1429867.A0A0G4P244"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF15">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL20379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="310" mass="33894" checksum="C37992962CDF35B0" modified="2015-09-16" version="1">MAGLTEAQVASFKENGYLVLPDYLTPTEVTALLAETNKLLEEFPLESHPLTQFTTGDETVDHVGDDYFLDSGDKIRFFFEPDAFSTEPDPLTGRAALLKPKNRAVNKIGHSLHTLSPPFKAISLNERNAAVAQSLGFADPRVLQSMVICKQPSIGGAVPSHRDSEFLYTDPPSAVGWWYALQDAGPANGTLGMYKGSHTGSKGGHIARRFVRKENGAGTEFIENRGPSLPKGMEEEKSSEATDEDLEILDIKAGSLVLIHGNVLHKSEKNTSLNSRYAYTFHVIEGAEGWEYDARNWLQPPASGFSKLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2D6</accession>
    <name>A0A0G4P2D6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S004g000423</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S12 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P2D6"/>
    <dbReference type="STRING" id="1429867.A0A0G4P2D6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF9">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="12"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL20482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="495" mass="55442" checksum="E388229C93CECCF1" modified="2015-09-16" version="1">MSSEQSPFDDGFDTLVKEQLDKWKVPGLSIAIIHGPNTYTKAYGKAELLDHSTGRPSREMTTDALFATCSTTKAFTGATTSIAIQDSKATEFPIDWDTPLASLIPEDFVLENDYATNNITLEDALSHRSGMPEHNWTLALFSKKGPTTDSIVRAMRHMPLATPPRTKYHYSNYMYIAVSHALEQHTGENLRAFMKKRIWDPLGMSETFFSSSEAKANPTTATKLVQAYNWVPTKEGGKFIAQPEHDWPANSGAGSIVSNVLDYAHWVRELIERTGPLKGHDSLMDPRTIYLQNDDLNLPAPYHAYALGWVVDNYRGQHFYSHGGGWPGYASWVGFVPEKKFGFVVMGNSFSARYAAFRLVTYLLDRRLGLSDDPKYEEQIAACIERQTETWESSLRNEVMEESKKRHSTGATVTIQMLDGGLTADLQDRVIPCELSLVHASGEFFVGRIHNAGLDLLSPFPVEFYIDAAGVAQRVGLLLEPAMKEEKFWFGRCRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2N8</accession>
    <name>A0A0G4P2N8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S004g000526</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P2N8"/>
    <dbReference type="STRING" id="1429867.A0A0G4P2N8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="92"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL20585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="685" mass="76879" checksum="A9BE3F8692C3FEE4" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P368</accession>
    <name>A0A0G4P368_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S004g000639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P368"/>
    <dbReference type="STRING" id="1429867.A0A0G4P368"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL20698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="338" mass="38963" checksum="7ECAB29E656284C9" modified="2015-09-16" version="1">MGGWEIYCAICGGTFFSEVDMDPEGTDKDHYRYEVLRDCNVEWLDKVCVLGINDQAHGNDKSFLTDDGRYWDYGQVHVSRVDDPNLPQRDDDDDIPMTAYHDFSEIGLPCVFPFHAICYHDILRRCLRQESPEQIEKAVLFDVFENLNGDPYVRLQLNYGEPEPLAEQVWHHPQGQESLVVNPVQIPQLESELDVITRSLSKKAAPSPRSRSEDIFNTLPFELRHEIFKLLPAGSILALKAASLAMHSTALPCDLWKRTLMSEIPWLWEVHDIDAFQSQEVEDITSKLLLDIQKKSLYTSENDDYIFGLANRRRIWGVCEQIRSRYLERLKGISNAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3P0</accession>
    <name>A0A0G4P3P0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gelsolin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S005g000068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL20904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P3P0"/>
    <dbReference type="STRING" id="1429867.A0A0G4P3P0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008154">
        <property type="term" value="P:actin polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11290">
        <property type="entry name" value="gelsolin_S1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF130">
        <property type="entry name" value="SEVERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00597">
        <property type="entry name" value="GELSOLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gelsolin-like" evidence="1">
        <location>
            <begin position="66"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="1">
        <location>
            <begin position="190"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="1">
        <location>
            <begin position="313"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL20904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="392" mass="44007" checksum="2116BFDC4EACDF57" modified="2015-09-16" version="1">MAPHEGLVHPKEYDIKDSNVELIGSDLDHRVKYNSALTEPAWKHIGQAPGLTVWRIENFQVIPWPKEKTGQFYDGDSFIVLHTYKVGDDKLGHDIFFWLGSKTTQDEAGVAAYKTVELDEFLQGAATQHREVQQHPSDEFLALFRNYAIRSGGVRSGFTHVEPEERVEVTTLLRVFKHPGIARVDSLIVHEVEPTWKSLDENDVFVLDKGDKIWVWQGKKCSPMEKAKAAQVVNDMTQAKHVDVEVLSQLESRSRIFVDLLGGKDAAPSTLEAPRPGRFAKRGADESARSRKLFRLSDASGNLSFDLVKDGGRVDRSDLDGNDVFLYDTGNRLWVWQGAGASASEKAMWLKVAQFYVRKIQESQESSEAYLTPISKVAQGHESPAFLKALEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3Z6</accession>
    <name>A0A0G4P3Z6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S005g000230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21066.1"/>
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        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051710">
        <property type="entry name" value="Phosphatase_SH3-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469:SF27">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL21436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="595" mass="65024" checksum="933ABE3EBC3FBB4B" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5B3</accession>
    <name>A0A0G4P5B3_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase II holoenzyme cyclin-like subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S006g000037</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SRB8-11 complex, a regulatory module of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P5B3"/>
    <dbReference type="STRING" id="1429867.A0A0G4P5B3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20513">
        <property type="entry name" value="CYCLIN_CCNC_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000092">
        <property type="entry name" value="RNA polymerase II holoenzyme cyclin-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028758">
        <property type="entry name" value="Cyclin, C/H/G types"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="7 12" id="KW-0195">Cyclin</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Cyclin-like" evidence="13">
        <location>
            <begin position="53"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CRL21497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="304" mass="34440" checksum="5E98E7B05567C1C7" modified="2015-09-16" version="1">MAANYWASTQRRHWLFSREKLADIREGLREKDKVAHSQFPLPDQRLLNIYFNQQLIKLGKRMSTRQQAIATAQVYLKRFYTKNEIRQTSPYLVLTTAFYLACKMEECPQHIRFVVGEARGLWPEFITPDVAKLGECEFALISELSSQLIVHHPYRALSELQTELSLTSDEVALAWSVINDHYLTDLPLLHPPHVIAIMAIIVAVVFKPTHPSTYPGTGQSALAGSMRDGGGIQMLAALSDRTGSGPPPKIQKLVGWLAESEVDIKAVIECTQELVSLYEVWEQYSEKNCKELLGRMVKSKNLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5K1</accession>
    <name>A0A0G4P5K1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S006g000125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P5K1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195063" evidence="1">
        <location>
            <begin position="18"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL21585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="144" mass="15769" checksum="FF0AE7F2FB060F10" modified="2015-09-16" version="1">MQLTTILPIVLASLATARPAALQTQTITDDIIWSVSNFTVGCSQGGCVYKYDIVGRENAMTPKFRTHCSGITGEKAACDDKNITTIISPAANPDWNVDVTHTWKSQLSDSSLVTWFQHGAKNVTVLDHNPIRFVMKPTQEYGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5R0</accession>
    <name>A0A0G4P5R0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">endo-1,3(4)-beta-glucanase</fullName>
            <ecNumber evidence="4">3.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S006g000154</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;3)- or (1-&gt;4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolyzed is itself substituted at C-3.</text>
            <dbReference type="EC" id="3.2.1.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.6" evidence="4"/>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P5R0"/>
    <dbReference type="STRING" id="1429867.A0A0G4P5R0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000114">
        <property type="entry name" value="Probable endo-1,3(4)-beta-glucanase NFIA_089530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF42">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G02280)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="11">
        <location>
            <begin position="52"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL21614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="353" mass="38603" checksum="8EB40AC7E5A30BD6" modified="2015-09-16" version="1">MHEDYYPTDQYSKWDPRGWSLMKKIFLAAGIIAVIVAVVVGAVLGVRANRYPNYSKLDYSLKDEFSGSSFFDNFEYFTDTDPTNGFVQYIDRAAATWLNLTSATNTSAVLKVDTTYSGSEAANGRQSVRVTSNNTYADGLFIFDVIHTPYGCGTWPALWLTDPSNWPAHGEIDVVEATNAGTFGTQSTLHTSEGCTMGVKRKESGTVENTNCYYEANDSAGCGVKGTSSTYGPEFNSNGGGVYAMELRDAGIRVWQWVRSKIPSDITSGSPDPSTWGKAFADFPNTDCNIGSHFKNQSIIINISLCGDLAGASKYYTTQSSCPGNCTTFVRDNATSFETAYWEFGSFKVYQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5X3</accession>
    <name>A0A0G4P5X3_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Probable beta-glucosidase E</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Beta-D-glucoside glucohydrolase E</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Cellobiase E</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Gentiobiase E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">PCAMFM013_S006g000224</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P5X3"/>
    <dbReference type="STRING" id="1429867.A0A0G4P5X3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF20">
        <property type="entry name" value="BETA-GLUCOSIDASE E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 24" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fibronectin type III-like" evidence="23">
        <location>
            <begin position="973"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="875"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="927"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="891"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00039576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00041269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00041599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00041811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CRL21684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1065" mass="116498" checksum="47D78A655E6C306A" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6C6</accession>
    <name>A0A0G4P6C6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S006g000411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P6C6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL21871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="70" mass="8383" checksum="243414CF41FC21F2" modified="2015-09-16" version="1">MILHFTGSTISQFLQIEESDEPRRPRVKRERLYSELQHPSFDYLEAQMEDHKFLPYSTILEEEENSHESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6E1</accession>
    <name>A0A0G4P6E1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Translation elongation factor EF1B, gamma chain, conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S006g000420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GST_N_EF1Bgamma"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Elongation factor 1 gamma"/>
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        <property type="entry name" value="Elongation factor 1-gamma 1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Translation elongation factor EF1B, gamma chain, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-GSTs"/>
    </dbReference>
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        <property type="entry name" value="EF1B_G_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036433">
        <property type="entry name" value="EF1B_G_C_sf"/>
    </dbReference>
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        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
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        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
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        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986:SF1">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00647">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01183">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89942">
        <property type="entry name" value="eEF1-gamma domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50040">
        <property type="entry name" value="EF1G_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="6">
        <location>
            <begin position="2"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="7">
        <location>
            <begin position="91"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="EF-1-gamma C-terminal" evidence="5">
        <location>
            <begin position="249"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL21880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="410" mass="45910" checksum="615974206FFF552E" modified="2015-09-16" version="1">MAFGKLYGLPDNGRTISILVAAKHNDLDLELVKTEANSAAEFNTSAEYLKLNPTGKIPAFEGANGFTLSEVIAIAVYVTSQNEKTTLLGKTKQDYASILRWMSFLNAEVLPKFGAWYRPLLGVDSYNKKVVDEAAKTALKAISALETHLVANTYLVGERITLADIFGASLLTRAFATVLDKTWREANPATTRWYNTIINQDAFKAVFPEPKLAEEVIKYVAPKKEPKPKAAAPAAAAPAEAPAAEAPKAKHPLEALGKPTLILDDWKRKFSNEDPRTVAMPWFWEHFKADEYSLWKVNYRYNNELKLTFMANNLIGGFQTRLEASRKYLFGAQSVYGENYDCVVYGAYMTRGQEWEPAFTVGPDYEGYEFTKLDPSNEADRKLVEDMWSQDVPVTVDGKVKEWTDGHVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6Z8</accession>
    <name>A0A0G4P6Z8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S007g000072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P6Z8"/>
    <dbReference type="STRING" id="1429867.A0A0G4P6Z8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46100">
        <property type="entry name" value="IMP2'P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46100:SF4">
        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="424"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL22091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="649" mass="70382" checksum="EBE8592B577DD631" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7K8</accession>
    <name>A0A0G4P7K8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S007g000235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P7K8"/>
    <dbReference type="STRING" id="1429867.A0A0G4P7K8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050276">
        <property type="entry name" value="MshD_Acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43617:SF9">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43617">
        <property type="entry name" value="L-AMINO ACID N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL22254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="175" mass="19699" checksum="3C955C341E1A32CD" modified="2015-09-16" version="1">MNELNFRVATEEDAAQLQQLVESAFRTEDSRKGWTDDLGLSSSFRLDVQEIVAMITKPDSVMLMATNDQNTLVGSIGTSKRDANHAHLFMLAIDTSQQRGGIGRQVLAYAEDYCQRTWGVTTLGLNALSNRQQLISWYSRRGYKPTGETSPFPREKFGNLVLPDDLCFVEFEKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7S6</accession>
    <name>A0A0G4P7S6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S007g000362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P7S6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL22381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="81" mass="9440" checksum="8B3E20827B82FF98" modified="2015-09-16" version="1">MKNRLNRHRDVAEPVHFKIETGRIPVHMIDTTASIDAEHAMYMEDSRGPREIAEQSTCFQHTPYTQYRIAPVSVWYGVPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
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    <name>A0A0G4P8U6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of chromosome condensation/beta-lactamase-inhibitor protein II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S008g000170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">FM 013</strain>
        </source>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Protein FMP25, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR053245">
        <property type="entry name" value="MitoProcess-Associated"/>
    </dbReference>
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        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47563">
        <property type="entry name" value="PROTEIN FMP25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47563:SF1">
        <property type="entry name" value="PROTEIN FMP25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <location>
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            <end position="332"/>
        </location>
    </feature>
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            <end position="394"/>
        </location>
    </feature>
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        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL22741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="576" mass="63406" checksum="302F8547581BCA1A" modified="2015-09-16" version="1"> </sequence>
</entry>
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    <accession>A0A0G4P960</accession>
    <name>A0A0G4P960_PENC3</name>
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        <submittedName>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL22840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="393" mass="45371" checksum="CD50882982F2E8C3" modified="2015-09-16" version="1">MESAKSERRGDWGKARSWLRLMENKMKSGRLVEALEKKKTIQGKHNRGVQEDVVTALFVDRDWVKACSLVSEMIGNIPKSFASLSECNEALVRGDFHGARRVLDVHPSPLRGALRPLVDLAEAIHNDDQERVTSISLFLDTYSDQSQRIFLHPSNGASSEKCDDHFGAVGSLPSQIDNSTHLEAQIREAELRGDWSQAMDLLLRIPEKTTYRRLLRRLNAGRSAQNEIDEDLERQAKKAELNGDWAKARSFLSRIKGDFGEFPLAALAYSEARLNRNDEHVQLLVELQRKYPDPRLIQVELDHFLQFLEHAELNGPPARAEVLRNSFVFQRMVETGIIWNKPHDFRKVFEMMAEDIRDAHDRLWYKLPHRNPRYRTHLRILTQKGDMVEELHI</sequence>
</entry>
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    <accession>A0A0G4P9A8</accession>
    <name>A0A0G4P9A8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S008g000332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793141">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4P9A8"/>
    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
    <dbReference type="InterPro" id="IPR053008">
        <property type="entry name" value="Phomopsin_biosynth_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL22903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="235" mass="26562" checksum="5F8419C1A8ECB26D" modified="2015-09-16" version="1">MTLFCGSKPKYDQLPNDTSPVSIQRQRRSRVTRWLLYCVVIPCNIILVALGIYGLTSFFIAGKMPAATAISCGCGATVDEAIAMGCKYDALSVSWLPPRCRDDELTAEFNQAGPGGEWLYWADRNGTELLTLQQVSALANKPLEEAQFWTTFGWHVSHCSFYWRKEYRMRQKGLEVEHRYDRESHIKHCQMAFMSRVALDEMNTRAAVGLGGDRVGAVRTEAQGGNEHQQHDNHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P9V7</accession>
    <name>A0A0G4P9V7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S009g000041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P9V7"/>
    <dbReference type="STRING" id="1429867.A0A0G4P9V7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL23101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="207" mass="20440" checksum="C66CFDF101358D55" modified="2015-09-16" version="1">MPGVPDALNQVKKGFKRFFSLRKKAAKKATEQQAEPAPAVTAAPVAAAAAAASETPAAKPTAPAATPDSAPDAAKVPEANDASTAQPAASSEMTATAGPVETHYEPEAAAAAPAPEPAVQTEAPVAKAEEPATKTEAPAAAPEPAVQPEESVAKPEEAAVKPEEPVAKTEAPAAEEPAAKVEESPAQPEAAAAAPAEAAAKTDAPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-11-27" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAA0</accession>
    <name>A0A0G4PAA0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pyridoxal phosphate-dependent enzyme, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S009g000186</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-aminocyclopropane-1-carboxylate + H2O = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16933"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58360"/>
            <dbReference type="EC" id="3.5.99.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ACC deaminase/D-cysteine desulfhydrase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PAA0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PAA0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008660">
        <property type="term" value="F:1-aminocyclopropane-1-carboxylate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019148">
        <property type="term" value="F:D-cysteine desulfhydrase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009310">
        <property type="term" value="P:amine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06449">
        <property type="entry name" value="ACCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027278">
        <property type="entry name" value="ACCD_DCysDesulf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005965">
        <property type="entry name" value="ACP_carboxylate_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01274">
        <property type="entry name" value="ACC_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43780">
        <property type="entry name" value="1-AMINOCYCLOPROPANE-1-CARBOXYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43780:SF2">
        <property type="entry name" value="1-AMINOCYCLOPROPANE-1-CARBOXYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006278">
        <property type="entry name" value="ACCD_DCysDesulf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="8">
        <location>
            <begin position="27"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006278-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006278-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL23246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="365" mass="39541" checksum="7992C8C647848FA5" modified="2015-09-16" version="1">MTSPKSTDLNPVPLPAPFSTIPRTPLLLGPSPIHPLPRITADLAKNNPHPHVTIYAKRDDLNSAYAYGGNKTRKLEYLLAEAQAQGCTTLVSIGGVQSNHTRQVAAVAARSGLKARLVQEHWVDWTDPGYESTGNIQLSRLMGADVRLDPSGFGIEHKNTAAAVVEQAKADGEKPYYIPAGASDHPLGGLGFARWAFEVRQQEAEMGVFFDTVLVCAVTGSTFAGMIAGFKLLEKLYPEDAKRKVIGIDASATVEATKAQVLRIAKNTAAKIGLSEDDITEEDVILDERYHAGIYGVPDRQTWDAIEYAAKMEAFITDPVYEGKSFAGMMDMIRRGEIKGGNILYAHLGGQLALNAYSELGRTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAF6</accession>
    <name>A0A0G4PAF6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S009g000238</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PAF6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PAF6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF35">
        <property type="entry name" value="RTA1 DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL23298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="289" mass="31977" checksum="9880E803147A63C8" modified="2015-09-16" version="1">MAPPVGWIAYDYYPSMGAAVVFIVLFAIVTLMHTFHLFRTRTWFFIPLLIGGYFELVGYIGRAMSSKQSPDWTIGPYVMQSTLLLIAPALFAASIYMELGRIIIMVKGERLALIRVNWMTKIFVAGDVLSFLMQASGAGIMVTGANSTDPSSSTSTGQNVIIGGLIVQIVFFGFFLLSSLIFQKRLGSHAEARAVADQYPWRKHMWALQLASILVLIRSVIRVVEYAQGTHGYLMQHEVFIYVFDGLLMFAMMVILVVIHPSEVNYLLGRGNVVTAMGGLKVMEGSNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAT2</accession>
    <name>A0A0G4PAT2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S009g000367</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PAT2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PAT2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF45">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="82"/>
            <end position="123"/>
        </location>
    </feature>
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</entry>
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    <sequence length="230" mass="23946" checksum="126D841690B38DB8" modified="2015-09-16" version="1">MRFIVPLLAAAGLASAGLLETVVKRDDYWGGSVSLGPSKSTIVNAVTTLIPGPAPSTQNGVLFLWPGMSNGTGDLVQTTLESWSSNAWCGATTGQWCVRASVFGSFGQLDGTGSPVSGTDEVRIEYDLESDGQTWTQTVTNGETGTVLSTYSHESGPYMRGYGTGTECNDNCSGTIAAQKYLNTVITLASADTTFGSTIASAGGATYTEVTSSEGGKVWTIKEIDIPSMH</sequence>
</entry>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL23470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="401" mass="45793" checksum="C9CD5382CB8802D4" modified="2015-09-16" version="1">MSEPDNKPGSESNIHRIQERWDSLNEMFQNTDPEPTEPVGSADDLEAEIRQAQAQLSRLKKQRELIDIKQKVAEEERELELARGRLLAATSLELPPATPASTPSRGEPKQNSKAGIDGAQKDLVAARSEQITTPAPLTKAADRRPSEAKPTEPKPSPKPANNLVSGLNLEQLRALAAATRSPAAQTVVKTESRSSLQPSARPFHPETSVHAPPVPNVPVYNGRALGEFKNFSMGLERHFDKYPEWYKIDERKVTRALKHVALNIEDEWKRHIRHLPADKITYASFCTFLIHQLQSGVYPDVARSRYMDSYQRPAQSVTDFSNWMQQWVPHFPNNDSERDRMRHLFEHLMNRVRNEADKTHLDFDNYYEFVEYLQRVEDSIGSRAESLGRRVINPRKRPRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBQ0</accession>
    <name>A0A0G4PBQ0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Six-bladed beta-propeller, TolB-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S010g000194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PBQ0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PBQ0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="WD40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32161">
        <property type="entry name" value="DPP6 N-TERMINAL DOMAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32161:SF8">
        <property type="entry name" value="DPP6 N-TERMINAL DOMAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69304">
        <property type="entry name" value="Tricorn protease N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195334" evidence="1">
        <location>
            <begin position="19"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL23756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="677" mass="75209" checksum="E193202C790B06A4" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBV6</accession>
    <name>A0A0G4PBV6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-serine ammonia-lyase</fullName>
            <ecNumber evidence="5">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S010g000250</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="5"/>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PBV6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PBV6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000040">
        <property type="entry name" value="L-serine dehydratase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF4">
        <property type="entry name" value="DEHYDRATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="12">
        <location>
            <begin position="20"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="352"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL23812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="439" mass="46727" checksum="0991686207E8723D" modified="2015-09-16" version="1">MGSIDISACDQLQFKTPWIETPLVESACLSRAAGCRIFLKLENVQPSGSFKSRAMGNQILSHLRNPANVGRRVHFYASSGGNAGLAAVCAARSLGYPCTVVVPMGTKPLMLDKIRAAGAADVIRHGETFSEAGEYMRETIMKTSNGDDHDVIKIALHPFDNQPIWEGNGTIIDELETQLPPATSPEDKKAYNDRALPLDAILCSVGGGGLLNGLVMGIEKRRQKKQITSSSSSTPNPIHLLAIETAGTDSLAAAIANKSLISLPKITSQATSLGAVRVSETTFQYAVSPPPGIKVHSTVLSDADAARGVLRLANDERLLVELACGVCIEAAIGDAATAVPASVTAGAGAQSIKKRKRGSVETDVTYRDEGYGDDRSISPDNETDQELEPQVGEKLNSKLKQLVPNLNSQSRVVIIVCGGSYVTIDMACEWRKMLDEGWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PC56</accession>
    <name>A0A0G4PC56_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S010g000343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PC56"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL23905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="68" mass="7867" checksum="2DBE52BAB2A476D8" modified="2015-09-16" version="1">MGCRELGLNLQGLRLRFHNNVEDMDHDENAMGGLWDNLRAAMCNTTNSSFTLWFCSVDREKGFRNENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PD75</accession>
    <name>A0A0G4PD75_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">hydroxyacid-oxoacid transhydrogenase</fullName>
            <ecNumber evidence="4">1.1.99.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S011g000274</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + acetoacetate</text>
            <dbReference type="Rhea" id="RHEA:23048"/>
            <dbReference type="ChEBI" id="CHEBI:11047"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + succinate semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:24734"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16724"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.24" evidence="4"/>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PD75"/>
    <dbReference type="STRING" id="1429867.A0A0G4PD75"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047988">
        <property type="term" value="F:hydroxyacid-oxoacid transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08190">
        <property type="entry name" value="HOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000009">
        <property type="entry name" value="Fe-containing alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000003">
        <property type="entry name" value="Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042157">
        <property type="entry name" value="HOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF83">
        <property type="entry name" value="HYDROXYACID-OXOACID TRANSHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="9">
        <location>
            <begin position="76"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="10">
        <location>
            <begin position="298"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL24280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="496" mass="53507" checksum="DF45A9D266B91EC7" modified="2015-09-16" version="1">MVSPAIRVAPSAANRALNLLRTVQYSHPPNCPCHKNPNHHHNHQQTPSLLNHVKRRMSTPVDRSREKEYAFEMAASSIRFGPGATKEVGMDFTNLGAKRVCIVTDSNVAKLDAMKQAVEGLTREGIEFTIFDKVRTEPKDSSIKEAIAFAKPYKPDAFLAVGGGSVIDTAKLMNLYTVFPEADFLDFVNAPLGKGRPVDRPLLPLVAVPTTAGTGSETTGTAIFDLVSKKAKTGIAHRNLKPTLGICDPLNTRTMPSAVHAASGLDVLCHSLESWTAIPYNERTPRPTNPINRPAYQGANPISDIFSLAALRSTVKYLPRAVRDPNDHEAQSEMLLAATLAGVGFGNAGVHLCHGMSYPISSQNPGYKHAGYEVDHPIIPHGVSVAVTAPAVFRFTAASNPDRHLAAAEAFGVDISNVKRESAGEVLGEAIAKFLVTLGDQPRGLKDLGFKAADLEGLVEGTIPQQRVLMLAPNLSKELEAERGELRNLLEESLDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PD78</accession>
    <name>A0A0G4PD78_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-ketoacyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S011g000198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PD78"/>
    <dbReference type="STRING" id="1429867.A0A0G4PD78"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="TesA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase TesA-like" evidence="1">
        <location>
            <begin position="41"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL24204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="291" mass="33173" checksum="BC8D0E523D6E0AD9" modified="2015-09-16" version="1">MTDEELEGRLSELFIHFTPALSTESKTPLEASKRPNMFLFFAVTGTSIQYRLLSQRLPTYKVIGVDHLRTNQPEAYPSITSMAADLAAILRRQQPRGPYTLGGFSFGGLVAWAVAKYLEEQHGETVRLILMDSEALVQAPIPPQTSMQDSQSAAAEQEMREKMYERLFDIPSREIADPVTIPELAEFRDMLLTQAHHNLAIHDVFRPDVLHAPVLLIRRCMEKEDYPKQVRIDSKNRHQGACQETNGFAEFAAGRLDVRCVPSSDHYTMLKEERCLQAIGKILEEDWRERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PD92</accession>
    <name>A0A0G4PD92_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Mitochondrial fission 1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S011g000213</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the FIS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PD92"/>
    <dbReference type="STRING" id="1429867.A0A0G4PD92"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12212">
        <property type="entry name" value="Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000179">
        <property type="entry name" value="Mitochondrial fission 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016543">
        <property type="entry name" value="Fis1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033745">
        <property type="entry name" value="Fis1_cytosol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028061">
        <property type="entry name" value="Fis1_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028058">
        <property type="entry name" value="Fis1_TPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247:SF0">
        <property type="entry name" value="MITOCHONDRIAL FISSION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 11 TPR REPEAT PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14853">
        <property type="entry name" value="Fis1_TPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14852">
        <property type="entry name" value="Fis1_TPR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008835">
        <property type="entry name" value="TPR_repeat_11_Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR008835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CRL24219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="152" mass="16698" checksum="31BA148986135078" modified="2015-09-16" version="1">MSNLPYAADAESPLKPAELQVLRAQYEKEGDYVGIQTKFNYAWGLIKSNIRSEQQEGVRLLSEIFRGAPERRRECLYYLALGNFKLGNYGEARRYNDLLLEKEPANLQAASLGGLIDDKVAKEGLVGVAIVGGLALVAGVVGSLVIKGTRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PD99</accession>
    <name>A0A0G4PD99_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S011g000299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PD99"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL24305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="411" mass="47065" checksum="84F620C2EDD44610" modified="2015-09-16" version="1">MAGNTPSPPAVNAFEDTTIRYLLFRVMSGNKICKATELAACLPQWLGDVEKNNLVPHDIPELLTHLLLPFVTSSILEDIANLSFPDSFTGSQKWMMKLRILMDHNVHERLLRKLESMGDEEVSFEDLCDQENAQEDSVNDYLVADPKRTVQFDHDMRDVMTRGDKDAMKKHTDVFYVTGYVAWTVRSPYWNVALATDDQGNRLLSDDVLDRVLPKWRQILTGETIPTLKYGVVDSFRSWLASEEKKASYLGKPWPNTPIKNVSSASEPNFGSPKTPEPYSRFPYSRPRSTDANRLSPLESTPDVTNSEQTEMLREILAEVRELRNMIRQTIERNEALEFAENQIYESWHQGYAPIPQAMQPNYPVPQEGPFVGVQYYDPTLEQDWQHWNPQYYDQDPTTMPGPGPGSAYHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDG3</accession>
    <name>A0A0G4PDG3_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Altered inheritance of mitochondria protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S011g000364</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM6 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PDG3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PDG3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08577">
        <property type="entry name" value="PI-PLCc_GDPD_SF_unchar3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039559">
        <property type="entry name" value="AIM6_PI-PLC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL24370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="438" mass="49171" checksum="7C3A8EC6F6F78779" modified="2015-09-16" version="1">MTSSRPSQSSSVSSLHFDPYRDSDTEDPKLNVPERVGYSARSRCQAGTLTSSVLSENPSKRKRSRRSRYLHSLRRATIGVFIMLGIIQFISIACGIILSFFPDEYDRAVHNWLDSVNSTSTVDNARWPTDISRDIVPVGCHSHNDYWRRVPLYSALQAGCIGVEADVWLFDDELYVGHSTSSLTEQRTLQSMYIDPIITILERQNPTTKFDQGGDSPVHGVFDTDPAQSLILLIDFKTAGPATWHAVVKQLAPLRDRGYLTHFNGDEFIQGPVTVVGTGNTPFNLVAANNTYRDIFFDAPLDKLVDADQPDNILQLDAALIPGTDLGQGQSGMPDIITASTFNTSNSFYASVSFKKSIGHPWPFHFTQSQMDRIRSQVRVAHQHGLKVRYWALPSWPRSLRNHIWRVLAQEGVDILNVDDLVDATKGDWNTSVFDWWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDJ6</accession>
    <name>A0A0G4PDJ6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">proline--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S011g000375</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="2"/>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PDJ6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PDJ6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00862">
        <property type="entry name" value="ProRS_anticodon_zinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.110.30:FF:000001">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000007">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000005">
        <property type="entry name" value="bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382:SF2">
        <property type="entry name" value="BIFUNCTIONAL GLUTAMATE_PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PROLYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="124"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL24381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="597" mass="65915" checksum="BB8FA470E6A8FAF1" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PF33</accession>
    <name>A0A0G4PF33_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S013g000192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL24949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PF33"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL24949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="212" mass="23671" checksum="53D80A73AE00DA6B" modified="2015-09-16" version="1">MLRDSRYSSTHSSGSSGGNGYVISVNICGRGDVHQGDPPAHWEVMLHKQGETDGDVYRVRKNEDFVYEDPVQTRVVESATSYGRNEIQHLSDRSKEAAARVLNAYGKDKSNLPRRNATSQEWTVGALGALEREKLVPQGTRDYWSRSIGQASLDVGDRLRRDGASWIPSTTAYYKGREPADATFGKEQVRQPVNRYNLDEFAALSSSSKSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PF71</accession>
    <name>A0A0G4PF71_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidate cytidylyltransferase, mitochondrial</fullName>
            <ecNumber evidence="6">2.7.7.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">CDP-diacylglycerol synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PCAMFM013_S013g000180</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAM41 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6"/>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL24937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PF71"/>
    <dbReference type="STRING" id="1429867.A0A0G4PF71"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015222">
        <property type="entry name" value="Tam41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13619">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13619:SF0">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09139">
        <property type="entry name" value="Tam41_Mmp37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028840">
        <property type="entry name" value="Mmp37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="17" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="485"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="491"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="507"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CRL24937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="522" mass="58603" checksum="012A0E4C371C59E3" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PFK7</accession>
    <name>A0A0G4PFK7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S013g000334</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asteroid family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL25091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PFK7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PFK7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026832">
        <property type="entry name" value="Asteroid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039436">
        <property type="entry name" value="Asteroid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665">
        <property type="entry name" value="ASTEROID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665:SF1">
        <property type="entry name" value="PROTEIN ASTEROID HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12813">
        <property type="entry name" value="XPG_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asteroid" evidence="2">
        <location>
            <begin position="156"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL25091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="574" mass="64928" checksum="2938469BE5BAA58B" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PFV7</accession>
    <name>A0A0G4PFV7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S014g000078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PFV7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL25182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="89" mass="10381" checksum="12A9E875C07BA0D5" modified="2015-09-16" version="1">MIYCRCCCNTNICTEYLVPPYRDTGGVNCILFTAYIRVSVQCEELDLFRDHATFRVASPRYMWGFLSREKKIACIFPIWSHSNSIVKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGL7</accession>
    <name>A0A0G4PGL7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Outer membrane protein, MIM1/TOM13, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S015g000072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793148">
        <property type="protein sequence ID" value="CRL25486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PGL7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PGL7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013262">
        <property type="entry name" value="OMP_MIM1/TOM13_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28241">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28241:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08219">
        <property type="entry name" value="TOM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL25486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="130" mass="14069" checksum="2F47245F89066181" modified="2015-09-16" version="1">MASDAASASAAELYDSAMTVPSDSENYSANHEMSSSVPSTASSLVMLYKPPSVWGLLRGAAINLFLPFVNGLMLGFGELFAHEAAFRLGWSNTKIFPNHRRSHAVGPGVEMRELPSERRRPGLRDTASLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PHG8</accession>
    <name>A0A0G4PHG8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S015g000246</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793148">
        <property type="protein sequence ID" value="CRL25660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PHG8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PHG8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="10"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL25660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="262" mass="27805" checksum="27ADDB3C771F7102" modified="2015-09-16" version="1">MSTNKELTGKVAIITGSSRGIGAAIALKFAHRGADVAINYVSNATAAESVVEQIRALGVRALAIKADVSQEEEVKTMFENVHREFGRLDIAVSNSGIEHFGDLSEVKGSDIDAIFAVNVKGQYFVAQQAHRFMEDYGRVMLTSSISAVKGVPRHAVYAASKAAVQGMTKCLAMDFGPRNITVNCIAAGGVKTDMYAEMSAKYIPGGDKMSPQQIDEALSKWSPLGRPGEVEDVAGVAALIASPDSQWLTGQTWQVSGGAYMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PID5</accession>
    <name>A0A0G4PID5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S016g000244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793149">
        <property type="protein sequence ID" value="CRL25963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PID5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF1">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="202"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL25963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="506" mass="56910" checksum="D442BD06387CC767" modified="2015-09-16" version="1">MSGLEIGLALPGIIDLCLKYGKAIVTAYKDFKHANEEFEERKLAIDVAWAKTSEQLAFLRRVWDQLSENYRDLQSRMLRHFEKKLEAAVRELSKLDDQAAKSGSRLLGKSKAAKYALLKKESLDRAIQNLRVWQNEFDTTWYLVLLIADEAIDKALVKRTGTEELSVARHVRSALRPEPQREATVFLSGNKLQSARRSEIPYSTSEIVEIAGIGTFILDSADCSSRKDAVTFSKNVRNLAMRLQQVDANGFHLLKCHGVARTTDPNTKQLLSFDFIFNFPKGCQKPQSLRSHLLSRATHSLSDRISLAKQLATSISYIHVLEFVHKNIRPETILIFDGVGSHLGPLYLLGFRAFRMADNKTLRLGNSIWSENIYQHPDRQGSNPGVDYVMQHDIYSLGVCLLEIGLWDSLVSSEGAANVSLAGVNCDPSTFNRDSSLKDHFMTLAKEQLPIRMGEMYTQVVVNCLTCMDETNEDFGDESEFEDGDGILIGVKYIEKILLLLGEITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PIZ8</accession>
    <name>A0A0G4PIZ8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aromatic-ring hydroxylase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S017g000169</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HG793150">
        <property type="protein sequence ID" value="CRL26186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PIZ8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PIZ8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF19">
        <property type="entry name" value="BINDING MONOOXYGENASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0274">FAD</keyword>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="14"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL26186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="530" mass="58182" checksum="D6F9535431288B79" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJS3</accession>
    <name>A0A0G4PJS3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polynucleotidyl transferase, ribonuclease H fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S019g000025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJS3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJS3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
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        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL26609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="117" mass="13132" checksum="7B2047235AEA5A49" modified="2015-09-16" version="1">MPSGQIYLEGCLCLLEWCAGKIQVELRWIPEHEDIPGNETADTLAKEAATTQETDIHYINTGTDINHNRYIRLAAAAKKGMKRNSAIEWEKSWAKGGKTARRTRGMIEAPNKSNLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-11-27" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJW5</accession>
    <name>A0A0G4PJW5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S018g000136</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJW5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJW5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF132">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="46"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="295"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL26443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="385" mass="42991" checksum="FD11F8E4AF752015" modified="2015-09-16" version="1">MAMDLLYIRDAIFRRDNDGILMSSRGAQGLIVSVVFTALATCFVGMRMYTRMKLMNRVEANDWMVIIALVNSYIFMALDIIEAVSGMGVHFKDIPPNIFLRQMKAFWLTIPFYNAAVLCAKASILMQYFRVFPTHRMRVVCWIMITILAIYGTWAVISAFLNCIPVAKFWDDSIQGYCLNKTKLWFSNASMHISTDIAILIIPIPALMAVDLPRKQKLALMIMFALGGFVCITSIIRLISLKEIADSSDPTYDNVGAASWSAIECNTGIICACLPTLKPLVARIFPSMVSTFNASRPTRGDTTQRNSDWNDNASTLGTPGEEHEYGAGDPERVLALVPGTGFRSSLKRWTREEEKKLAQITSVPGPRPKRVTRPRPLPADLAVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKI1</accession>
    <name>A0A0G4PKI1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S019g000128</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKI1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PKI1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="NmrA-like"/>
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        <property type="entry name" value="NmrA-like_oxidored"/>
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        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR42748:SF30">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
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        <property type="entry name" value="NmrA"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="8"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL26711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="332" mass="37325" checksum="B23AC904DC26A034" modified="2015-09-16" version="1">MQKEEQPRTIVVLGSTGNQGRGVVEFLLREPGLETCLVRAVTRDTKSPAARQLLENYQTPDERLSLITGDVYDPESLENAFSGAYGVFAVTSEHISKKIDTEEDMKHELQAGLNIISAAKLCEIQHFVFSSLPNMKQATGGRFEKLLHMDHKYIIEQWAKRDLAAVTCLLPAFFLTNLNRPQYSRRENGVVRFCSPIPGDKLVQWLDPVHDMGVFAARVFALGVSKTKNKNYVVAAPKMRMQDFATIFTRVTGHQAIYSPTTLDEWADMASEAVGPGFKEDIRQMMEWASIMPDDKICYGALDPTEDPSWDDLGLRASSFEDWLKRTGWTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PL92</accession>
    <name>A0A0G4PL92_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Src homology-3 domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S020g000080</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DOCK family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793153">
        <property type="protein sequence ID" value="CRL26921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4PL92"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08679">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11684">
        <property type="entry name" value="DHR2_DOCK"/>
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    </dbReference>
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        <property type="entry name" value="Dedicator of cytokinesis N-terminal subdomain"/>
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    </dbReference>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DEDICATOR OF CYTOKINESIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653:SF10">
        <property type="entry name" value="MYOBLAST CITY, ISOFORM B"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="7"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="C2 DOCK-type" evidence="9">
        <location>
            <begin position="624"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="10">
        <location>
            <begin position="1448"/>
            <end position="1869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="422"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1860"/>
            <end position="1930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1956"/>
            <end position="2095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="425"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="478"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1867"/>
            <end position="1882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1897"/>
            <end position="1907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1994"/>
            <end position="2012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2013"/>
            <end position="2026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="2051"/>
            <end position="2060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="2068"/>
            <end position="2095"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL26921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="2127" mass="236035" checksum="BE81E1C60033A599" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PME3</accession>
    <name>A0A0G4PME3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S022g000209</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793155">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF9">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="48"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="469"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL27529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="497" mass="55717" checksum="05B3E6F483B0E336" modified="2015-09-16" version="1">MSEFKSTAMAKMPDAELNVGENTTYTDPEAERSYVRKIDFIVLPTLCLDCSIAQMYFFDCMDRSNLANAKTDGLEKDLNLKWNDYSLLILLFYIPFGLFDLPWNLLIKRFSGRIMLSINMKVSIVWGVLALCQCAAKDFGSLLAIRIILGVFEAGFFAGATFYLTLFYTRGEMGFRLAIMQSFAVLASAFSGLISFGAFQINDPAVKGWQWLFIIEGSMTLLTGVVAFFLLPDGAQKAWFLSDRERAAATARLLRDTSSEVDTPFDLKSAFESWSDWKFPVWCLITFTYPVAYATAMNFFPLIVQRLGYSVIKTNLWTVAPNLVGAVFLLCVAKSSDYFRERTLHIVFSLAVSLVGMIILIAIDVQSNKGVAYFACFLMAAGSYIPSCLVHAWHNNNNVHENSRAANTGFFVGLGNFAGVLSAGTFRTQYAPKYLPTLIATCCCNAVCIVLVLGLGGWMRMENHRRDSKQGLRLRENQTDTSQFKEGEKSPEWRYFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMM9</accession>
    <name>A0A0G4PMM9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sugar/inositol transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S022g000078</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793155">
        <property type="protein sequence ID" value="CRL27398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PMM9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PMM9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000044">
        <property type="entry name" value="Hexose transporter Hxt3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF91">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="53"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL27398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="550" mass="61158" checksum="652826F3F49330FD" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMQ9</accession>
    <name>A0A0G4PMQ9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S022g000103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793155">
        <property type="protein sequence ID" value="CRL27423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PMQ9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PMQ9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052777">
        <property type="entry name" value="Acetyltransferase_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43305">
        <property type="entry name" value="FAMILY N-ACETYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01380)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43305:SF1">
        <property type="entry name" value="FAMILY N-ACETYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01380)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL27423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="176" mass="19678" checksum="89AD5443400C68F2" modified="2015-09-16" version="1">MQIQIEAAQFPKDADSILSLFSGYAASLGIDLTFQSFQDELDSLPGKYAPSKGGSLLIAWADTGVREPNTNRLVDSISSRFPSALGCVALRRSSDGWCEMKRLYVLKEARGERLGEKLVEAILAQARDLGYRGMRLDTLPEMTAAQRLYRKYGFVDITPYYETPIQRTVFMGCEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMU8</accession>
    <name>A0A0G4PMU8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S024g000030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793157">
        <property type="protein sequence ID" value="CRL27775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PMU8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PMU8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027706">
        <property type="entry name" value="PGP_Pase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09419">
        <property type="entry name" value="PGP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL27775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="250" mass="27868" checksum="8BDE35C02E073739" modified="2015-09-16" version="1">MAGSPNSNLRGFNHAVQTLLKQPTQFLPHLTIPTFTHLPENLGPHLINTNKGLQTPPEKPPHTPTIRALVLDKDNTLCAAKTTSFPPQILAKLSSLRTSPTSLFNQTTNPHSILIVSNRAGSHPRFDGEISELEAQLAHLRIPVFRLPAGTEKKPFCGEEVVQWFRERGVVESPHEIAVVGDRLGTDVLMAGMMGSWSVWCKEGVFDVGMEGKPERNVLEKMEVWIEWFLREKGGYKAPLPMGWEKQKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PN66</accession>
    <name>A0A0G4PN66_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1264-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S023g000076</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OBAP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793156">
        <property type="protein sequence ID" value="CRL27618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PN66"/>
    <dbReference type="STRING" id="1429867.A0A0G4PN66"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31360:SF0">
        <property type="entry name" value="OIL BODY-ASSOCIATED PROTEIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06884">
        <property type="entry name" value="DUF1264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL27618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="26011" checksum="499658CE72CBD997" modified="2015-09-16" version="1">MSTPGKSCCADGNELPGDPRTMKSRVLERGAAMIQDFTPVKQICAHLNAFHIYANDPTRCVEANHYCTHLTEDVRQCLIYDSPNANARLIGVEYMVSPRIFSTLPAEERKLWHTHEFEVKSGMLVMPAPAGVPDAVWEAAETAEMQDVAPIYGKTYHFWQIDRGDPVPLGQPQLMGSFVSNESVKVAHPAGLDSLLEDRNKRYGLDHHQKAKKREGIEAVEKHPDADSWFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PN81</accession>
    <name>A0A0G4PN81_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Inorganic pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S024g000127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793157">
        <property type="protein sequence ID" value="CRL27872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PN81"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL27872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="499" mass="55373" checksum="9BA8D5E9312B2BD7" modified="2015-09-16" version="1">MTRIQPHEYSRPSYSHPSQNSFGTVPSSLRSGFSPVSQSVSVVVRNPPTTDNASESNQETRGGANLTGSDSREGDILETDLYYAPMPVGVAQHSEGDGSRLMSGSTTNRGTKRNHNDDDELDGDSSRQHRRLTTKEEIALFEICNQNADTFGSRSNLCKWWISIAAEFKRTHEGRSYSWHSVRRKVEMVTRQRIKFLEDQRQRGSNAPGSTAEELMNPQWLAAVDVWLPTWQRWEEAENRRIAKRDELKKRRQPQPWRQSSNNGDQDPWRNLPGSSATSPTDVNAAMMSMLHQPVTNPIGDAALPATSPTPSPSITGPAPPAHFLESPSTPVSGTTPLKLPPGFENMFSTPQLTSQVAPLPSISTPPVPQPDGRMVSAVLETLGKLNKHLDAAPGGGIDTSVASPVISALVQAASEPPVLASLRQSQHPQVQHPLQQQQQPQQGLTHIQIEQMKEELRHEMQAQFRSELERERLAMEEKLDSVQRTQDLILEMLRQEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PP76</accession>
    <name>A0A0G4PP76_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Oligopeptide transporter OPT superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S024g000176</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793157">
        <property type="protein sequence ID" value="CRL27921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PP76"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="503"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="665"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="707"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="742"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL27921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="790" mass="89751" checksum="E6A18784D3886823" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPJ2</accession>
    <name>A0A0G4PPJ2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zinc finger, CCHC-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S025g000186</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793158">
        <property type="protein sequence ID" value="CRL28128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PPJ2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PPJ2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="304"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL28128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="440" mass="49612" checksum="A723DD9AD4CF2821" modified="2015-09-16" version="1">MADPPTGGPEPPPTNTQETQASFSVKDFQPRVSIDTGQIIGKRTRNGEAYTPAEGTGRITTREVWKLIDNLKDIIHHQTTLIESTKADLEEVKHDQNILQEQNDRLHEEAAIAASGTSDPQSSLQRPEKDRNYVRISTQRSSVDPRDNENREGNSFGRYLSTASANTYIRSALLSAPPTQDAQVAGIGTTKTGYLVRFKDPGSADIARNNTEWLNELGNNTKLIKPRFGIVVHRTPTENFDLENTNSQAIQTIIEENDLAEQDFQIEDIWFDSTEGAEYILNNSLLVRQRYIGSIERREIKKKRCFRCQRFGHLAWSCKETPRCGHCTGQHERQRYPPGIRARCLDCSGKHPTVETDATRFRSLIYINRRVPTASHRQTPDSQILLFSVYLPSVPLYSGDNTSAEPTLTAIQNIITSTLQDNRQTTSIILSGDFNRHHPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQI3</accession>
    <name>A0A0G4PQI3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Initiator tRNA phosphoribosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S029g000070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793162">
        <property type="protein sequence ID" value="CRL28654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQI3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PQI3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043399">
        <property type="term" value="F:tRNA adenosine(64)-2'-O-ribosylphosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019988">
        <property type="term" value="P:charged-tRNA amino acid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007306">
        <property type="entry name" value="Rit1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033421">
        <property type="entry name" value="Rit1_DUSP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033449">
        <property type="entry name" value="Rit1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31811">
        <property type="entry name" value="TRNA A64-2'-O-RIBOSYLPHOSPHATE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31811:SF0">
        <property type="entry name" value="TRNA A64-2'-O-RIBOSYLPHOSPHATE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04179">
        <property type="entry name" value="Init_tRNA_PT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17184">
        <property type="entry name" value="Rit1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007747">
        <property type="entry name" value="Ribosyl_Ptfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rit1 N-terminal" evidence="2">
        <location>
            <begin position="125"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Rit1 DUSP-like" evidence="1">
        <location>
            <begin position="435"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL28654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="550" mass="60186" checksum="AD613CABECB87204" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQJ5</accession>
    <name>A0A0G4PQJ5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromatin modification-related protein EAF3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Chromatin modification-related protein eaf3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S030g000024</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MRG family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793163">
        <property type="protein sequence ID" value="CRL28737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQJ5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PQJ5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.30:FF:000004">
        <property type="entry name" value="Putative Chromatin modification-related protein eaf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.30">
        <property type="entry name" value="MRG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038217">
        <property type="entry name" value="MRG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026541">
        <property type="entry name" value="MRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053820">
        <property type="entry name" value="MSL3_chromo-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF15">
        <property type="entry name" value="MSL COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05712">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22732">
        <property type="entry name" value="MSL3_chromo-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038133">
        <property type="entry name" value="HAT_Nua4_EAF3/MRG15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51640">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="14">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="88"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00057322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CRL28737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="308" mass="35982" checksum="E139D64D3E48C8B7" modified="2015-09-16" version="1">MAPISMYSKDEKVLCFHHEILYDAKILDVRHKDSSDKKSPFEYQVHYKGWKNTWDDWVLEDRLRKHTEDNRELANNLRREAEASFRLKNTKVTAKKRAGSDRDSVRDSEERGSVPGRGTKRARDSEIEKEESFNIRPSVRIIMPDNLKSLLVDDWEQVTKNQCVISLPAKYPVRQILQDWHEEELPKRSGSSADEDVLEEVVAGIQEYFDKCLDKILLYRHERPQYRGLRKKFEAATGDLADKGPIDVYGAEHLIRLFSTMPELIAQTNMDMQATNRLREEISKLSMWLSKNSEKYFATSYQPAESTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQV2</accession>
    <name>A0A0G4PQV2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S028g000059</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793161">
        <property type="protein sequence ID" value="CRL28506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQV2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PQV2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AUSG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL28506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="568" mass="63951" checksum="4476232C67F8BBA0" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQX1</accession>
    <name>A0A0G4PQX1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dipeptidase</fullName>
            <ecNumber evidence="2">3.4.13.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S028g000116</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.19" evidence="2"/>
    <dbReference type="EMBL" id="HG793161">
        <property type="protein sequence ID" value="CRL28563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQX1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PQX1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443:SF12">
        <property type="entry name" value="DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="MICROSOMAL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU341113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL28563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="437" mass="48523" checksum="4009112265AA3B19" modified="2015-09-16" version="1">MTDEKTSILESQGDAPTLRQKKRPFNLLSLFLCIIVATAWFTRSRYPFSRLSIEERVEKILSQTPLIDGHDDFPILVRELFHNRVNDRNFTEAFVTDKFPGHVDIPRLRQGRVGGTFWSVFVPCPKNGSDFSDENYAASVRETMEQVDIMSRVQQAYPKVFSSPPNGTTAMSAFREGKIISPLGIEGLHSIGNSLAHLRIFYELGVSYATLTHNCHNRYADAAILELPGGGIKKSDPLWHGVSEEGQKLVFEMNRLGMTVDLAHVSTETMRDVLGAGKSEWIGSRAPVIYSHSSAYALCPHPRNVPDDILELVREKNSLVMVNFSPDFISCTASDRANGIPDVDATLERVADHIMYIGNLIGFEHVGIGSDFDGIPTVPRGLEDVSRFPHLIMELLKRGVSDKDASKVAGGNLLRVWKKVDEVALEMQAEGALPAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PR66</accession>
    <name>A0A0G4PR66_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TspO/MBR-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S031g000063</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TspO/BZRP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793164">
        <property type="protein sequence ID" value="CRL28895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PR66"/>
    <dbReference type="STRING" id="1429867.A0A0G4PR66"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033013">
        <property type="term" value="P:tetrapyrrole metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15904">
        <property type="entry name" value="TSPO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.100:FF:000001">
        <property type="entry name" value="translocator protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.100">
        <property type="entry name" value="TspO/MBR protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038330">
        <property type="entry name" value="TspO/MBR-related_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004307">
        <property type="entry name" value="TspO_MBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057">
        <property type="entry name" value="PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057:SF0">
        <property type="entry name" value="TRANSLOCATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03073">
        <property type="entry name" value="TspO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005859">
        <property type="entry name" value="PBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195556" evidence="7">
        <location>
            <begin position="21"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL28895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="183" mass="20183" checksum="648E1B2C7FD85ED1" modified="2015-09-16" version="1">MPWSFALPHVLLTNPYLAVATPITAGTTVALLTNRKQNRETYKQLKQPPYSPPGWLFAPAWTLIYGLMGYASHHATTTASRSFSLAVRDANSTAQTLYTTQLALNFLWMPLFFRLGRPAVALGDLALLAGNVGALMVNWWTADRTAFWCLVPYAVWLGYAAYLNAGCGILNGWTLPTGKERSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PR98</accession>
    <name>A0A0G4PR98_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S031g000107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793164">
        <property type="protein sequence ID" value="CRL28939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PR98"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL28939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="114" mass="12819" checksum="526828881F3B50CB" modified="2015-09-16" version="1">MLEPFRGGKKRADRQRQGLLRRMMCEGGCSSGRGDIVYLMKEALKDTLLWCLKGCPLRLALAHLYLTTAINHFDQSSISDDPYLVTDNASCFKGRNRKRQSCPPRLSIADSLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRS3</accession>
    <name>A0A0G4PRS3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WD40/YVTN repeat-like-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S033g000045</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat UTP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793166">
        <property type="protein sequence ID" value="CRL29125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PRS3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PRS3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000549">
        <property type="entry name" value="Small nucleolar ribonucleoprotein complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045161">
        <property type="entry name" value="Utp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359">
        <property type="entry name" value="WD-REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="587"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="196"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="215"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL29125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="615" mass="67813" checksum="0A017FD53B2D510D" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PSU7</accession>
    <name>A0A0G4PSU7_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S037g000036</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="HG793170">
        <property type="protein sequence ID" value="CRL29549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PSU7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PSU7"/>
    <dbReference type="ESTHER" id="penca-a0a0g4psu7">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000316">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="47"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL29549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="557" mass="60214" checksum="79810D17FD75EBEB" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PTG1</accession>
    <name>A0A0G4PTG1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S038g000048</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Dupont J."/>
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        </source>
    </evidence>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUL8</accession>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL30031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="212" mass="23961" checksum="DE024724E7A09F07" modified="2015-09-16" version="1">MQYYICKGQTVVPQDHVKILGLLMDTRLKYKEHIARAASKGLEAAMELRRLRGLTPAAARQLFTSTVAPVVDYASNVWMHACKDKAMGPINRVQRVGAQAIVGIFLTVATSVAEAEAYIATAQHRFWRRAAKMWTDIHTLPETNPLRRNTDRIRKFRRYHRSPLYQVADALKHIDMETLETINPFILAPWEARVQASVKATPQSPIVLGGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVH2</accession>
    <name>A0A0G4PVH2_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Small nuclear ribonucleoprotein Sm D1</fullName>
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        <alternativeName>
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        </alternativeName>
    </protein>
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        <name evidence="11" type="ORF">PCAMFM013_S045g000023</name>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in splicing regulation. Facilitates post-transcriptional gene silencing (PTGS) by limiting the degradation of transgene aberrant RNAs by the RNA quality control (RQC) machinery, thus favoring their entry into cytoplasmic siRNA bodies where they can trigger PTGS. Does not participate in the production of small RNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793178">
        <property type="protein sequence ID" value="CRL30157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PVH2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PVH2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097525">
        <property type="term" value="C:spliceosomal snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01724">
        <property type="entry name" value="Sm_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000008">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034102">
        <property type="entry name" value="Sm_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8 11" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="2"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="80"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL30157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="125" mass="13540" checksum="DF139EE861E1F3A6" modified="2015-09-16" version="1">MKLVRFLMKCANETVTVELKNGTILHGTIVAVSPQMNTSLRAVKMTPKGRDTVSLDTINIRGSTIRYYILPDSLPLDTLLVDDAPKPKNKARKETDRGRGGGRGGPRGRGGRGGPPRGRARGRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVM4</accession>
    <name>A0A0G4PVM4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Intradiol ring-cleavage dioxygenase, core</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S050g000003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793183">
        <property type="protein sequence ID" value="CRL30356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PVM4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PVM4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03457">
        <property type="entry name" value="intradiol_dioxygenase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315:SF9">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195996" evidence="1">
        <location>
            <begin position="18"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="2">
        <location>
            <begin position="127"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL30356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="338" mass="36691" checksum="241F62298D9A07BC" modified="2015-09-16" version="1">MQFGKLALLAMTGLAIGHPGVHEPTSYNALSKKSFLQNAKRSLNLCADHLERRGVNARAKARRAATVAKYHKRGMVARDTDKVVNTSHHSSLNVTPNTSESELFSKNPICILAPEGETGPFWVKGELVRSDVRDGEDGIPIILDGQFIDINTCEPIQDLYWDVWNCNSTGVYSGVQSSMNGNGNDATNLDKTFLRGIQKTNADGVAQFKTMFPGHYDGRTTHVHVIAHVGAQEQANKTLSGGHVAHIGQLFFDQDLITQVENTYPYNTNTVSITENADDHVVIAETEDSNSDPFFEYALLGETVEDGLFAWITLGVNASASYEASNAATLTSSGGVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PWG0</accession>
    <name>A0A0G4PWG0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Taurine catabolism dioxygenase TauD/TfdA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S052g000024</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793185">
        <property type="protein sequence ID" value="CRL30467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PWG0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PWG0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF10">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="47"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL30467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="369" mass="41417" checksum="7F77DD75FD4806F2" modified="2015-09-16" version="1">MSPALDTQNVPEVLDLKAKNINTPQASLLREPLKSSGSLKEYENFNSTPIIGTEFPNVQLTEILKDETKIRDLAILVSQRGVVFFRDQNISSEEQKVLGQKLGELSGKPSTSKLHRHAVSNSKRGIAVDENGHLDDEISVISSESYRKLYGDRYKPNSGRLASEGWHADITFEHVPSDYALLKITELPEDQSGGDTLWASGYELYDRLSPTIQKLAEELKVVHHQPSFNKIAKEQGIELIQGDRGAPENTGFDFKATHPLIRTNPVTGWKSLFGAGQQVEHGWIEGVTQLESQVLKKLFNKLLFENHDLQVRFRWGKNDLAIWDNRSVYHTATNDYGGKRQGNRVVSLGEIPYFDPLSKSRREALAEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PWN3</accession>
    <name>A0A0G4PWN3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S060g000025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793193">
        <property type="protein sequence ID" value="CRL30815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PWN3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL30815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="162" mass="19375" checksum="B0FECAFF1906832B" modified="2015-09-16" version="1">MVRYIHVYGRQHGITIDTAHEHIKRLEQAINHKFEEKAQCHGICFHQDRIRTDPSWLRRELVYVCAGEKGINLLNEVWYHTWIFRINLKIEGNFDERTIREPLGLHMKVERIQFTEMGPNETTKRMRHLRDKIPRSTDGSVKMNDTGDCLYFGRRFQIGRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PWV4</accession>
    <name>A0A0G4PWV4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S056g000011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793189">
        <property type="protein sequence ID" value="CRL30638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PWV4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="110" mass="11992" checksum="99D8BE255F982AAC" modified="2015-09-16" version="1">MNTDSVPRNTDSVFRNTRPSPGAPTLSSGSPTRPQEHQSIPRNISPSPGTSVHPQEHRLCLQPARKDHLRSIPGPRARPENLTSLSFSPLLPSTFFLQYGQILGASSNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PX11</accession>
    <name>A0A0G4PX11_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S063g000021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793196">
        <property type="protein sequence ID" value="CRL30915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PX11"/>
    <dbReference type="STRING" id="1429867.A0A0G4PX11"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL30915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="171" mass="19397" checksum="ED840E8BA121517A" modified="2015-09-16" version="1">MSQSQQSEFASSLYDVEFDNSAYLTPNNCPTTPSGSQQTFDALENSFLRPAIPLIAPSTFERVGPDRRRLYILYDGMSHSDWVEWWLQTDYGSKSKISWDSNHLSDVWKHYVQVAYSVDGAAKVMYKRCSTILEHPYTIKKDMNGKDGCYGTTTMIRHLKTSSCVRAAGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PY09</accession>
    <name>A0A0G4PY09_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S095g000007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793226">
        <property type="protein sequence ID" value="CRL31245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PY09"/>
    <dbReference type="STRING" id="1429867.A0A0G4PY09"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF213">
        <property type="entry name" value="DEPENDENT OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="62"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL31245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="175" mass="18667" checksum="0FFE264E49D69395" modified="2015-09-16" version="1">MSVVLSLLTSAAVSPIERQRALDRIHSDPGIPSDPTTSSFWLQDPHPSFAQPSSKPLPTEADVVIIGSGITGASIARILLQNRAKSSPASSHPAVVMLEARDICSGATGRNGGHILETADDYAEIADVFGEESARKLLRFCLAHLSEMLGVAEELGLTEVTQARKVQFLIAYFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PYA4</accession>
    <name>A0A0G4PYA4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S083g000010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793214">
        <property type="protein sequence ID" value="CRL31183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PYA4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PYA4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL31183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="244" mass="27387" checksum="45057A80BB203EA1" modified="2015-09-16" version="1">MQVGLPKLLYVSWPTTATILCDSKSALQSIQNARNKSGQRIVHAILSVATEVQARNIALPREAARPGKTHPFRPLLTRKNAHIRRKIRAQWEHEWKSSAKGGHLKKIDNTLPAAHTRKLYGSLPRNRAYLFTQLRTGHNWLSTYAKTFDFREDDQYVCGAQETVTHVLVDCPRLRELRRKLRREVGDAFNSVSSLLGGSTEGKKGKPDTVSRAKTVNAVLDFAEASQRFRSRAPRGQPNNGSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PYJ9</accession>
    <name>A0A0G4PYJ9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S3Jg000067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793312">
        <property type="protein sequence ID" value="CRL31456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PYJ9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL31456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="50" mass="5617" checksum="34B34A124E74B01F" modified="2015-09-16" version="1">MPKHPDEPCLGAREETPIPPDEKQHGGHPWRNISQDSSDVQTGHALHVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PZD0</accession>
    <name>A0A0G4PZD0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription factor, fungi</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S4Jg000042</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793313">
        <property type="protein sequence ID" value="CRL31520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PZD0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PZD0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF82">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="155"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL31520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="423" mass="48248" checksum="FFC6B7A0F8361123" modified="2015-09-16" version="1">MQNHERSFTYAGRIGDIIQRWDRTEQCNEWQAPTAVTSPIANLPIHLDYILCEKTQYYRFIARKARTIRKHWRDRHCWVAPVNRSGRRTPHGPSATEQQIQQFTRVVQCQRAFSNAPVSLTSGNANMLWVKLGPIFGFRSKAVTTDGELILGSITWQRLGEFATNIFELGVHRDTTSSTALPLFILESRRRLFAAAYQFDKGIATFLGRPPQISWRHSDCCLPLDIGDHVLTGDPEILDAAQTSLDPQGWNMGKAYQRATWIRFPERTDLLIATILSTVLILGRQWEQSVAIQRDLTWILLLYGIPGASVLIRALQKQAQTGRPMLYSGSQASLIRNLSVFISHLELTARPEQESSTYFNRTAAVFTRILDEILEPRLKIPAPYRDSERNFDVDFDRLFSLDMDGIQLLQNTDFGASFGQMQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NSP5</accession>
    <name>A0A0G4NSP5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S001g000080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NSP5"/>
    <dbReference type="STRING" id="1429867.A0A0G4NSP5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051122">
        <property type="entry name" value="SDR_DHRS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057571">
        <property type="entry name" value="SDR_PhqE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43477">
        <property type="entry name" value="DIHYDROANTICAPSIN 7-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43477:SF1">
        <property type="entry name" value="DIHYDROANTICAPSIN 7-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23441">
        <property type="entry name" value="SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL17120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="251" mass="26471" checksum="306B37760F257E44" modified="2015-09-16" version="1">MPPITGSNILVIGGSSGIGAAVANLAAAEENVHVSIASSNLARVEKTVQRLQTAVPNAQIKGYTVDIGGDDAESRLENLLAEVTAATGRPLDHIVYTAVKLEFKFLHDVTVDFLRGDAQFLVFVPLLIAKIAPPFINQNYRSSITFTSGRIAEKPMKGVAVLAGWGAALFGIVRTLALDLAPIRVNLVSPGTTNTEIQGPEREKKMAAAAERALLGKVGTPEEVAEAYIYLMKDSNNTGTCVSTSGGDLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NT27</accession>
    <name>A0A0G4NT27_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fatty acid hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S001g000079</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NT27"/>
    <dbReference type="STRING" id="1429867.A0A0G4NT27"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL17119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="117" mass="13685" checksum="05FD4E0E236B2754" modified="2015-09-16" version="1">MYYSIHRVLHWRLLYRRVHRFHHETQQDGLLTGLDVHPLEYVFAQMATELMSAWMVGATLPELCFLSSVAKIFAMYSHSRSDAKAWISVMEHEAHHHDGRHNFGVTGLMDWAFGTMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NT96</accession>
    <name>A0A0G4NT96_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peroxidase</fullName>
            <ecNumber evidence="14">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PCAMFM013_S001g000261</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 Fe(II)-[cytochrome c] + H2O2 + 2 H(+) = 2 Fe(III)-[cytochrome c] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16581"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.11.1.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Forms a one-to-one complex with cytochrome c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="14"/>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NT96"/>
    <dbReference type="STRING" id="1429867.A0A0G4NT96"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004130">
        <property type="term" value="F:cytochrome-c peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00691">
        <property type="entry name" value="ascorbate_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000009">
        <property type="entry name" value="Ascorbate peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000005">
        <property type="entry name" value="Cytochrome c peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002207">
        <property type="entry name" value="Peroxidase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF58">
        <property type="entry name" value="CYTOCHROME C PEROXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00459">
        <property type="entry name" value="ASPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 14 17" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="16">
        <location>
            <begin position="115"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CRL17301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="365" mass="40036" checksum="353340F01821F900" modified="2015-09-16" version="1">MASAARTASRAFLRSTPATSSFRPAVRSTRFAIPTNGLRTSACRGYSSEAGSEKSSSSFGIWALGIGALGAAGGAYLYLSGDSSPKGPFVPTQADYQKVYDAIASRLADETDYDDGSYGPVLVRLAWHASGTYDKETGTGGSNGATMRFAPESDHGANAGLKTARDFLEPIKAQFPWITYSDLWTLGGACAIQEASGPTIPWRPGREDRDVAACTPDGRLPDATKDQRHIRDIFSRMGFDDREMVALIGAHALGRCHTDRSGFDGPWNFSPTLFTNEFFRLLVEEKWTPKKWNGPTQFTDKSTGTLMMLPTDMALVKDKGFKKHVERYAKDNDAFFKEFSDVFVKLLELGVPFKTEDRFVFKTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NTA2</accession>
    <name>A0A0G4NTA2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phytanoyl-CoA dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S001g000276</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NTA2"/>
    <dbReference type="STRING" id="1429867.A0A0G4NTA2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF48">
        <property type="entry name" value="ECTOINE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL17316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="275" mass="31447" checksum="6D6100CBD05EEFA8" modified="2015-09-16" version="1">MSPLTPEQIASYHENGYLLLRAGEHKLVDPTELKQWTQEVQAWPRVKGKWMPYDEININGERQLMRTERFIDYHSKFKSLVCGEQLAGILKAVSGDDMLLFKEKINYKQPQGNGFQAHLDAPAYDHIGRIEHITANIAIDAATPENGCLEVVRGSHKMKVEFAEAGRITPEWENTHEWTSVPLEMGDMLIFGSHLAHRSAENKTDKSRSSLYATFHSRSDGEDLREQYYKHRMEMFPPEHEREDGKDYSKGYQTYGFAAPFTKAQENVAATVDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NTG6</accession>
    <name>A0A0G4NTG6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S001g000357</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NTG6"/>
    <dbReference type="STRING" id="1429867.A0A0G4NTG6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07106">
        <property type="entry name" value="ALDH_AldA-AAD23400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000032">
        <property type="entry name" value="Probable aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044086">
        <property type="entry name" value="LUC3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="26"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL17397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="479" mass="52224" checksum="7091A551F849FC1B" modified="2015-09-16" version="1">MTTDAQTLDFTTFRNVINNELTTTTETRHGINPANTQPNPPVPVSTQEDLDKAVNAAKDAFKGWSKTSFEERRKALHAWADAIDANADGFAKTLTMEQGKPLTQSSVEVGLAGVWIRGITAIEITDNIIEETEDRKIVQRHTPIGVVGAIVPWNFPVLLAVGKIAPAIYTGNTIIVKPSPFTPYCDLKLVELATKFFPPGVVQCLSGEESLGPLFTAHPGIEKISFTGSIATGKRVMAACATTLKRVTLELGGNDPAIICDDVDIDAIIPKIGTLSYLCSSQICMMIKRLYVHEKIYDEFLEKLVAFVKTLKVGDGTEADTFFGPVQNQMQFEKAKDLFSSIGTENLKAALGGSIENSSGYYIHPTIIDNPPETSRVVQEEPFAPILPVLKWSDEDDVLERANALETGLGASVWSKDFERATRMADQLQSGVVWVNSHFDVAPNAPFGGHKQSGMGVEWGLAGLLGYCNSQTQWLKKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NTI5</accession>
    <name>A0A0G4NTI5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S001g000288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NTI5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL17328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="48" mass="5163" checksum="4897FD4A3614238E" modified="2015-09-16" version="1">MQSIARDAIGTMTPVPILKVPLKAPWFTLRFLLGGAGFRAAEGGRHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NU47</accession>
    <name>A0A0G4NU47_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dysferlin, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S001g000545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NU47"/>
    <dbReference type="STRING" id="1429867.A0A0G4NU47"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006614">
        <property type="entry name" value="Peroxin/Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051513">
        <property type="entry name" value="Tectonin_beta-prop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23250">
        <property type="entry name" value="DYSFERLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23250:SF1">
        <property type="entry name" value="TECTONIN BETA-PROPELLER REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00694">
        <property type="entry name" value="DysFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peroxin/Ferlin" evidence="2">
        <location>
            <begin position="253"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL17585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="514" mass="57921" checksum="4455B14444C9EECA" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NU77</accession>
    <name>A0A0G4NU77_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PCAMFM013_S001g000583</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NU77"/>
    <dbReference type="STRING" id="1429867.A0A0G4NU77"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046972">
        <property type="term" value="F:histone H4K16 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000067">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF219">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12 17" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="16">
        <location>
            <begin position="12"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="224"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="331"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="226"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CRL17623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="356" mass="40077" checksum="BD7C728DEE0FCCB6" modified="2015-09-16" version="1">MATPKSAPLQTPANRNVNNVVLGDLLFKPWNQSIYPEDLVAKDADRLYVCRWCFRYSCDVDIFEEHKRACEHRITPPGTKVYDHGGYAVWEVDGQNHKLFGQNLSLFAKLFLDHKTVFFDVATFLYYILTFTDPDDSDSYYVLGFFSKEKLSWDANNLACILIFPPYQHKQLGKLLMGVSYKLSGWDSNGGCIGGPEKPLSELGHKSYVRFWAERIARFLLRGKPSGSSLETDQQKPSSTPKGSRKRPLRETITVEELGQGTGMLTEDVITALKSMGLFEPQATPKKRKSTRTAAEEITTPPGQMVTICKSDVWEWAQAHHLSLDDPVREEGFEGLWPPDIVSDGDGQSVVASEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NU87</accession>
    <name>A0A0G4NU87_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NU87"/>
    <dbReference type="STRING" id="1429867.A0A0G4NU87"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL17633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="67" mass="7577" checksum="E5B2887A77804B5C" modified="2015-09-16" version="1">MITRVLEAPRYPQLNLWLYQDSSSLLAGTKQQEEDLKEDPMGSILMQPDAAERIEVELFTRLGGLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NUY5</accession>
    <name>A0A0G4NUY5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aflatoxin biosynthesis regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S001g000848</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        </subcellularLocation>
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    </dbReference>
    <dbReference type="CDD" id="cd12148">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TF_fung"/>
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        <property type="entry name" value="XnlR_reg_dom"/>
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    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF27">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="194"/>
            <end position="224"/>
        </location>
    </feature>
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        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="125"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="834"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="991"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="804"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="865"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL17888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1049" mass="115708" checksum="6AA202A74962436F" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NVC0</accession>
    <name>A0A0G4NVC0_PENC3</name>
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        <submittedName>
            <fullName evidence="1">Uridine kinase</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL18028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4NVC0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL18028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="238" mass="26681" checksum="EB7087D59F613583" modified="2015-09-16" version="1">MESEYRRLADTIRNQAEAHPKSRYLVAIAGIPGSGKTTTAEAVVQQLNQDSTSRAALLSMDGFHLSRAALDQLPNPREAHIRRGAPWTFDVDRFVDFITRLRTWSDETPLAEPYSGTWLPEDVIRAPTFDHKAKDPVENGISITPDAEIIIIEGNYLLLDDPGWRELAGLVDYRVFVDSDPLEARSRLAERHLRAGIENTLEDGYRRVDSNDFLNGVSIRDKLLAPDIIVKSMTVDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NVG9</accession>
    <name>A0A0G4NVG9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S001g001017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWI5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL18415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="65" mass="6619" checksum="F99BABA7318BB7E8" modified="2015-09-16" version="1">MNGNTEIPSNLGNSQCANKRGADWRPWALRIGPGGGPMGDTAGPTGQVDGTATANAKTFRGPHGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWQ8</accession>
    <name>A0A0G4NWQ8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosomal protein 60S</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S002g000413</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">P1 and P2 exist as dimers at the large ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWQ8"/>
    <dbReference type="STRING" id="1429867.A0A0G4NWQ8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002182">
        <property type="term" value="P:cytoplasmic translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05833">
        <property type="entry name" value="Ribosomal_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044076">
        <property type="entry name" value="Ribosomal_P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005194847" evidence="6">
        <location>
            <begin position="22"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL18543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="108" mass="10853" checksum="E7D81539C24A052B" modified="2015-09-16" version="1">MKYLAAYLLLALAGNEAPSSADIKSVLSSVGIDAEGDRLEKVIAELQGKDLQELISEGSTKLASVPSGGAGAAAPAAAAAGGAAAPAEEKVEEKEEESDEDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NX38</accession>
    <name>A0A0G4NX38_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Folic acid synthesis protein FOL1</fullName>
            <ecNumber evidence="10">2.5.1.15</ecNumber>
            <ecNumber evidence="12">2.7.6.3</ecNumber>
            <ecNumber evidence="11">4.1.2.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">Folic acid synthesis protein fol1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">PCAMFM013_S002g000475</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Catalyzes three sequential steps of tetrahydrofolate biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19949"/>
            <dbReference type="ChEBI" id="CHEBI:17836"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="EC" id="2.5.1.15"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the DHPS family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the DHNA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="22">In the central section; belongs to the HPPK family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="10"/>
    <dbReference type="EC" id="2.7.6.3" evidence="12"/>
    <dbReference type="EC" id="4.1.2.25" evidence="11"/>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NX38"/>
    <dbReference type="STRING" id="1429867.A0A0G4NX38"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.20:FF:000006">
        <property type="entry name" value="Dihydropteroate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.560:FF:000005">
        <property type="entry name" value="Folic acid synthesis protein fol1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="entry name" value="7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="entry name" value="Dihydropteroate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="FOLATE SYNTHESIS PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941:SF1">
        <property type="entry name" value="FOLIC ACID SYNTHESIS PROTEIN FOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="Dihydropteroate synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00792">
        <property type="entry name" value="DHPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00794">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="19" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="16" id="KW-0418">Kinase</keyword>
    <keyword evidence="18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="25">
        <location>
            <begin position="191"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00009640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00009951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00012458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00013043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00013253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00058009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00061548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00067568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00068111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="CRL18605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="465" mass="50919" checksum="7B4723B9A63C1ED3" modified="2015-09-16" version="1">MNLKFPSPDIHRAFIALGSNVGDRVEMIEQACLEMDRVGIKVKRTSSLFETAPMYVLDQDPFINGVCEVETTLEPLDLLDALQLIEIELGRKKLIDKGPRSIDLDILLYDQEIFSHERLNIPHNLMLERDFVLRPLSQLIPNEYPPLPGKDSQTYSTHLKALPPPEPTPMSTTPISPLFSSLHATDPKRSTHVMAILNLTPDSFSDGGKHAPTDLNYITETVRNFIASGATIIDIGGESTRPGSTPVGATEEIARVVPAIRHIRTSIPEAANIAISIDTYRASVAEAACAAGADIVNDISAGLLDPEMLPTVARIGKSVILMHMRGTPQTMTTLHDYPSGVIPEVAAELSARIAAAEDAGIRRWRIILDPGLGFAKIQPHDLEILKELPKLRAMPGLECFPWLMGPSRKRFIGHITGVKTPRERVWGTAATVSASVAGGADIVRVHDVQEMWQVTKVADAIYRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NX82</accession>
    <name>A0A0G4NX82_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Proteinase inhibitor, propeptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S002g000531</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="9">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NX82"/>
    <dbReference type="STRING" id="1429867.A0A0G4NX82"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF19">
        <property type="entry name" value="SERINE PROTEASE AORO, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005194863" evidence="10">
        <location>
            <begin position="19"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="11">
        <location>
            <begin position="236"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="589"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="630"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="631"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="649"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="651"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL18661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="672" mass="73233" checksum="2283BEE9BA452F2A" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYL4</accession>
    <name>A0A0G4NYL4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Citron-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S002g001035</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VAM6/VPS39 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL19165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NYL4"/>
    <dbReference type="STRING" id="1429867.A0A0G4NYL4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019452">
        <property type="entry name" value="VPS39/TGF_beta_rcpt-assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019453">
        <property type="entry name" value="VPS39/TGFA1_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF49">
        <property type="entry name" value="VAM6_VPS39-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10366">
        <property type="entry name" value="Vps39_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10367">
        <property type="entry name" value="zf-Vps39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CNH"/>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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        </reaction>
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        <location>
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        <location>
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        <location>
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</entry>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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            <dbReference type="EMBL" id="CRL19211.1"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZW5"/>
    <dbReference type="STRING" id="1429867.A0A0G4NZW5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF25">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 14 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="1">
        <location>
            <begin position="59"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL19610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="294" mass="32008" checksum="9C9E869A386FD5CC" modified="2015-09-16" version="1">MTTITTTHSLEEQGNSIPVKADAPIQAPSAQASLATGGYEFPGIPKIDDLHKKRQWQLEHMAGAFRVFARKGYTEGTSGHISVRDPIDPSTFWINPMGKHFGMLKASDMVHIDEEGQVIGGNKTAVNAAGFMIHSAIHKARPDVHAACHTHSPAGKAWSTFGRPLNIINQDSCNFWGTQAVYRAFGGVVLGADEGERIAEALGETGRVMVLQNHGLLTTGGTVDEAAYLFTLMERSCEVQIMVESTGIAQNLIGDKEAEFTAKVNADPETLYTEFQPDFEYEIWKSKGELCKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0H1</accession>
    <name>A0A0G4P0H1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Eukaryotic molybdopterin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S003g000579</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P0H1"/>
    <dbReference type="STRING" id="1429867.A0A0G4P0H1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02110">
        <property type="entry name" value="SO_family_Moco_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.420.10:FF:000002">
        <property type="entry name" value="sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF6">
        <property type="entry name" value="SULFITE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase molybdopterin-binding" evidence="5">
        <location>
            <begin position="183"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Moybdenum cofactor oxidoreductase dimerisation" evidence="6">
        <location>
            <begin position="390"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL19788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="565" mass="64481" checksum="EF5B5C6B17029E11" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P1C0</accession>
    <name>A0A0G4P1C0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl transferase, family 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S004g000018</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P1C0"/>
    <dbReference type="STRING" id="1429867.A0A0G4P1C0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01627">
        <property type="entry name" value="HAD_TPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1020:FF:000003">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase subunit Tps2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000036">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase subunit Tps2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000131">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1020">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase related protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF123">
        <property type="entry name" value="TREHALOSE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="34"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL20078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="943" mass="105645" checksum="102AC937534350EF" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P1C2</accession>
    <name>A0A0G4P1C2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S004g000055</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P1C2"/>
    <dbReference type="STRING" id="1429867.A0A0G4P1C2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055449">
        <property type="entry name" value="Iec3-like_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032742">
        <property type="entry name" value="Iec3_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24244">
        <property type="entry name" value="Iec3-like_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14612">
        <property type="entry name" value="Ino80_Iec3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit 3 N-terminal" evidence="3">
        <location>
            <begin position="29"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="INO80 complex subunit 3-like middle region" evidence="4">
        <location>
            <begin position="159"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL20115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="333" mass="37710" checksum="292EDDF37E794E6A" modified="2015-09-16" version="1">MAEPNDNRVTESLPNAPTAAPAPAKQSVRSFKKKYAKLKVRFELGTRESESLIREELRIEDLSKRIQEQNDQLLEVLLEFNDSLHVSPDVRFDLSMPTDPPLLPTAEQEIVPLINDATLAKQAWKEAKAGLTAGSIDTSAYRIIEDNIKRNKAFAPAQQYSTLSQTHQITTDAVEKKPDNDCERQLGYFTPEHETEYYLALDAKLGDEAAATQLTRIPDRPTFAERERDLSMRNPASVYNWLRRNQPQTLQDNEIASEKSASRPSNQRSSKRAPAQRKDEDMYDEDGTEAQPTPKNKRKREEDTGYRPKGGSSRSKKKKEEPTSNPSKVAKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P1J5</accession>
    <name>A0A0G4P1J5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DASH complex subunit SPC34</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Outer kinetochore protein SPC34</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PCAMFM013_S004g000088</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex SPC34 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P1J5"/>
    <dbReference type="STRING" id="1429867.A0A0G4P1J5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013966">
        <property type="entry name" value="Spc34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08657">
        <property type="entry name" value="DASH_Spc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="12 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CRL20148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="246" mass="27501" checksum="BFC21CEC21051D07" modified="2015-09-16" version="1">MSLLNSHLGQITLSSNAIADLPFPPPRIFTTALLGSHDITALIRDTEAHERALFQVDPSTNAHGPQRRATRRGTMFPAETERESMASRIYSARDNRNQSAVARVLGHDMMEEIKRSAGTSTRGPRGEVNIEVLLRGAEILCNVYPVAGAQEKIANLRYRHEMISESIAQLEGRVATNTAELDRMRHSYGDDEDDFSPPPVAQPEIPEVTDEDIERELAEIRNLEHRKRRLEERVTGMDRDLGGLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2R0</accession>
    <name>A0A0G4P2R0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ras small GTPase, Ras type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S004g000552</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P2R0"/>
    <dbReference type="STRING" id="1429867.A0A0G4P2R0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL20611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="83" mass="9288" checksum="26B5550BBB023D30" modified="2015-09-16" version="1">MQLCGRQKVVQRKMVLLGDGACGKTSALNVFTRGFFPTVYEPTVFGKRISSSTTYMWSSRYGIPPAKKSSTDCERCPTRTHMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P393</accession>
    <name>A0A0G4P393_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S004g000710</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="372" mass="42452" checksum="DF6AF575245C56A2" modified="2015-09-16" version="1">MSASRQQPGLACEECRKKKLRCDRRRPQCDQCEDSGTACLVNQVRSPRGPKKGHLKALRNRIATLESIINCDQGNLDPKEVSDGSEKYHSDETAHLLSPPQECIPNVTKTECRDIPYSIEASTITSPITPITPPDHENLDIIEADLDQLYFDRVHPVAPMLHQGRYFSWAQSYNKPASHICLQFSMWALAAASSAHLQHLRESLYTRARSAIDALDHDIESSSAACLQVAQAWLLLTHYEFRYMSYRRAWLTAGRAFRIIQLAKLHEIDRLNDVTVNMAHPEAWAEAEEKRRTYWLAYCLDRFLNISDEWPLSLHEEALCIYLPVSESDFQHSRPVLMDSLYDEIGTSGQKMLPPFAETIVLITLCWHSVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3I9</accession>
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    </organism>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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                <person name="Lacoste S."/>
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                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <end position="93"/>
        </location>
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            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL20900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="93" mass="10417" checksum="EDD790D795987CCE" modified="2015-09-16" version="1">MRPSYTNTRGPRDNARDCPHWGHGVANASFLRASIICTKLWEGLWEKIPLWPVFFTSLTSGTMHRGGVGGDMLPTQDNKKLFSNRRTASQVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P465</accession>
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        <recommendedName>
            <fullName evidence="10">ML-like domain-containing protein</fullName>
        </recommendedName>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Dupont J."/>
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                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
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                <person name="Lacoste S."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF2">
        <property type="entry name" value="FLAVIN CARRIER PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
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            <end position="757"/>
        </location>
    </feature>
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            <end position="358"/>
        </location>
    </feature>
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            <begin position="379"/>
            <end position="396"/>
        </location>
    </feature>
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        <location>
            <begin position="416"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="476"/>
            <end position="496"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="502"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="564"/>
            <end position="593"/>
        </location>
    </feature>
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        <location>
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            <end position="162"/>
        </location>
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        </location>
    </feature>
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            <end position="657"/>
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        </location>
    </feature>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL21094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="757" mass="82007" checksum="C99D2AEEFE44D328" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P4C7</accession>
    <name>A0A0G4P4C7_PENC3</name>
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        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S005g000291</name>
    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </evidence>
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    </evidence>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Renault P."/>
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    </dbReference>
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</entry>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <name evidence="10" type="ORF">PCAMFM013_S006g000450</name>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
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            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
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        <text evidence="2">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
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        <text evidence="3">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase HisB"/>
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    </dbReference>
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        <property type="entry name" value="Imidazole glycerol phosphate dehydratase, domain 1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
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        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
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        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE HIS7"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="32"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL21910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="244" mass="25978" checksum="9D5EEDF75E00EDAE" modified="2015-09-16" version="1">MSLTARTATISRATNETKIQISLSLDGGVLPPYEPSTHFPAPTDPKEAEASKKGIVPPKEASHATQFTPTQQITISTGIGFLDHMLHALAKHGGMSLAVRAKGDLYIDDHHTTEDTFLALGEAFTLALGARQSLERFGRGDAPLDEALSWAVIDLSSRPWAVINLGFKREKIGDLSTEMITHGLQSFAQAAGVTLHVGCTYGDNDHHRAESAFKALAVAIRNACKRRVAGDVGAGDVVSTKGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6G6</accession>
    <name>A0A0G4P6G6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Actin, gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S006g000457</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P6G6"/>
    <dbReference type="STRING" id="1429867.A0A0G4P6G6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000131">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000001">
        <property type="entry name" value="Actin, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL21917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="375" mass="41697" checksum="5EBCDBA66EE8A223" modified="2015-09-16" version="1">MEEEVAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHHGIMIGMGQKDSYVGDEAQSKRGILTLRYPIEHGVVTNWDDMEKIWHHTFYNELRVAPEEHPILLTEAPINPKSNREKMTQIVFETFNAPAFYVSIQAVLSLYASGRTTGIVLDSGDGVTHVVPIYEGFSLPHAISRVDMAGRDLTDYLMKILAERGYTFSTTAEREIVRDIKEKLCYVALDFEQEIQTASQSSSLEKSYELPDGQVITIGNERFRAPEALFQPNVLGLESGGIHVTTFNSIMKCDVDVRKDLYGNIVMSGGTTMYPGISDRMQKEITALAPSSMKVKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7J6</accession>
    <name>A0A0G4P7J6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA repair protein (XPGC)/yeast Rad</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S007g000294</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P7J6"/>
    <dbReference type="STRING" id="1429867.A0A0G4P7J6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09906">
        <property type="entry name" value="H3TH_YEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09870">
        <property type="entry name" value="PIN_YEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000037">
        <property type="entry name" value="Rad2-like endonuclease, putative (AFU_orthologue AFUA_3G13260)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000051">
        <property type="entry name" value="Rad2-like endonuclease, putative (AFU_orthologue AFUA_3G13260)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041177">
        <property type="entry name" value="GEN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037316">
        <property type="entry name" value="Yen1_H3TH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF75">
        <property type="entry name" value="ENDONUCLEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18380">
        <property type="entry name" value="GEN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="4">
        <location>
            <begin position="111"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="405"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="482"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="539"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="682"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="490"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="570"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="702"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="774"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="851"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL22313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="879" mass="96780" checksum="F6BBFDB7E84A849D" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7V4</accession>
    <name>A0A0G4P7V4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S007g000320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P7V4"/>
    <dbReference type="STRING" id="1429867.A0A0G4P7V4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195231" evidence="3">
        <location>
            <begin position="26"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL22339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="257" mass="27180" checksum="929F50FE69840A3D" modified="2015-09-16" version="1">MKSTYQPNLLFLILSILTSTPLVTSLCYYHDGTVASDPIYQPCSTIKDTIGMCCASNHSNPSGGNSANGITADLCLANGLCMNVLTYTNSAGKLGTNTTYWRNQCTISDWTNNVCLNVCTKESKLGEHTSTSTSLLIPSSTSTSLISSPTSTSTSSSPSSSKLSGGAIAGIAVGSVLGGIASLALFAFSFVRWKKKRIQRENEAEGLAINLHPDSRPQELENHIQTVGMKSVVHEKATGPQDTRAELPGEPVGRTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P816</accession>
    <name>A0A0G4P816_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Erg28-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S007g000452</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG28 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P816"/>
    <dbReference type="STRING" id="1429867.A0A0G4P816"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005352">
        <property type="entry name" value="Erg28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451:SF19">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03694">
        <property type="entry name" value="Erg28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL22471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="135" mass="14956" checksum="E4C5EE52DE2AF4DA" modified="2015-09-16" version="1">MDQYLAYLPQSEGFLPKWLFFVSVVSALNSLQAYTAPQYTSLLYSNGKVPATPLSGRIFGTWTFLSAVIRMTAAYNITNSVAYDLGMWTYGIALSHFVGELIFGNASLKGRFLNPLIVASGSLAWMFTQREAYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P876</accession>
    <name>A0A0G4P876_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleolar GTP-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S007g000445</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
            <location evidence="2 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P876"/>
    <dbReference type="STRING" id="1429867.A0A0G4P876"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01897">
        <property type="entry name" value="NOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000496">
        <property type="entry name" value="Nucleolar GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024926">
        <property type="entry name" value="NOG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041623">
        <property type="entry name" value="NOG1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010674">
        <property type="entry name" value="NOG1_Rossman_fold_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012973">
        <property type="entry name" value="NOG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45759">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06858">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17835">
        <property type="entry name" value="NOG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08155">
        <property type="entry name" value="NOGCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038919">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="OBG-type G" evidence="9">
        <location>
            <begin position="168"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="510"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="540"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="624"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
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</entry>
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</entry>
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    <accession>A0A0G4P9T1</accession>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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    </evidence>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
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                <person name="Abraham A.L."/>
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                <person name="Debuchy R."/>
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            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
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                <person name="Lacoste S."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="82" mass="9154" checksum="43C5143A2E6767FE" modified="2015-09-16" version="1">MLAANFDGRHLIFNLTENGRTIHRSREIIRLSERPTSPAPLLPNIFARPLTTVSPSYFGAVQLHSHLLLAIRAHIYGYAGFG</sequence>
</entry>
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    <accession>A0A0G4PBD8</accession>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </feature>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="CRL23605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="565" mass="68405" checksum="64E2355AFDC94E33" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBK0</accession>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF13">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="34"/>
            <end position="202"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL23649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="252" mass="27426" checksum="C372FD779008188D" modified="2015-09-16" version="1">MSWNLGQLPLSSSEIIYPASPLYQKESCTWAAQKDLKPRIIARPCTFSSLAALFSFLTHSNLNWAVRRTGVGSSSASDVLISLSAFDKFEYNVEDQIVVIGTGQTWGEVDRKVEENAPGHAVVGARCTYVGVGGSILSGGISWLSSEKGLAADPHNMLDARVVLTDGRILWASTEPELLWALRGGGGSFGVLVEVKLRVHPYPDKIYSGQISYPRSVFPVVAKAIERFTAECNDPKMAMHIFPLDLGRVVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PC48"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL23844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="49" mass="5218" checksum="F8900DF93674BD15" modified="2015-09-16" version="1">MHLLSPAPFPSPGPSPIAILNSTPCSMVRNVVLPRAEIIALRRRPSCPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PC93</accession>
    <name>A0A0G4PC93_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S010g000327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PC93"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL23889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="68" mass="7510" checksum="C597671C57AE8CCE" modified="2015-09-16" version="1">MRDPGGKPDRPLLQSRICLLGKETPAERRVWADPPVRLNLSGLTGSRLVLSIKFVAVKFQVTSFDAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PC98</accession>
    <name>A0A0G4PC98_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar protein-sorting-associated protein 36</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ESCRT-II complex subunit VPS36</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S010g000371</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the endosomal sorting complex required for transport II (ESCRT-II).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the VPS36 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PC98"/>
    <dbReference type="STRING" id="1429867.A0A0G4PC98"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000165">
        <property type="entry name" value="Vacuolar protein sorting protein (Vps36)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000527">
        <property type="entry name" value="Vacuolar protein sorting protein (Vps36), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021648">
        <property type="entry name" value="GLUE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037855">
        <property type="entry name" value="Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031558">
        <property type="entry name" value="Vps36-NZF-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128:SF12">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16988">
        <property type="entry name" value="Vps36-NZF-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11605">
        <property type="entry name" value="Vps36_ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51495">
        <property type="entry name" value="GLUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0967">Endosome</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GLUE N-terminal" evidence="11">
        <location>
            <begin position="6"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="89"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="317"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="105"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL23933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="616" mass="67015" checksum="79C7FB6CA1D00EF7" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCJ4</accession>
    <name>A0A0G4PCJ4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NGG1p interacting factor 3, NIF3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S011g000022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PCJ4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PCJ4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1390.30:FF:000001">
        <property type="entry name" value="GTP cyclohydrolase 1 type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1390.30:FF:000008">
        <property type="entry name" value="NGG1 interacting factor Nif3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.30">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="NGG1 INTERACTING FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799:SF13">
        <property type="entry name" value="NIF3-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="DUF34_NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602678-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL24028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="377" mass="40360" checksum="3F65B746610CB1F3" modified="2015-09-16" version="1">MSTPMRSSECSPFTNVVVSSMRKLYPEALADKSFDNTGLLLEAPFDKSRIQTNSVLLTIDLTTAVADEAIKNRNSIVVAYHPIIFRGLKSLTFADSQQRSLLRLAQHGISVYSPHTAVDTVPDGMADWLCDVVTGNFKKVQQTPKATISSCASSMYSAPSYPEAPIPAVQTQTSEAPAHTRSTIHPSPAASIPEGFESAGAGRLVTFTEKQSLTTLIDNIASGIGLPGGIPIAIPQGQSVDDISIRTVGMCPGSGSGVLLKGDGELPDLLLTGEMSHHEALAATERGSVVISLSHTNSERGYLRSAMQPKLLAEVKQQWDAAFQDSAKTVDDLKKFDGVPSAAVLQIRDLYKDQGDVVVSVSETDRDPYGIMIWRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCL0</accession>
    <name>A0A0G4PCL0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S011g000040</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PCL0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PCL0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000023">
        <property type="entry name" value="Fungal specific transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF8">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="9"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="11">
        <location>
            <begin position="270"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="563"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="608"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="564"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="608"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="631"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL24046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="790" mass="88051" checksum="1E02E43824413A6E" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCQ2</accession>
    <name>A0A0G4PCQ2_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chromatin modification-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S011g000071</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ING family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PCQ2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PCQ2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000177">
        <property type="entry name" value="PHD finger protein ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF42">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="559"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="241"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="400"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="432"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="542"/>
            <end position="557"/>
        </location>
    </feature>
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            <name>Zn(2+)</name>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
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        </source>
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        <source>
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        </source>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="618" mass="67796" checksum="352FCD96F7FE6CCF" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PD59</accession>
    <name>A0A0G4PD59_PENC3</name>
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        <recommendedName>
            <fullName evidence="4">Argininosuccinate synthase</fullName>
            <ecNumber evidence="3">6.3.4.5</ecNumber>
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        <alternativeName>
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        </alternativeName>
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        <name evidence="14" type="ORF">PCAMFM013_S011g000254</name>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
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    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the argininosuccinate synthase family. Type 1 subfamily.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginosuccinate synthase-like N-terminal" evidence="12">
        <location>
            <begin position="5"/>
            <end position="169"/>
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            <end position="405"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20979"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL24260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="416" mass="46473" checksum="40177EC9D05373B9" modified="2015-09-16" version="1">MAQGKVCLAYSGGLDTSCILKYLIEEGYEVVCFMADVGQEEDFEAAREKALKIGALKCEIADIRREFIEELCFPAIACNAVYENVYLLGTSLARPVIARAQIDVAQREGCFAVSHGCTGKGNDQVRFELAFYALQPDIKVIAPWRDPVFYERFKGRQDLLDYAEEKGIPVTSTKSKPWSMDENLAHCSYEAGILEDPDTTPPADMWKLTQDPLTAPDQPEDFTLYFEKGVPVKLEYTEAGKQKTVTDSVELFLTANAIARRHGVGRIDIVENRFIGIKSRGCYETPGLTCLRSAHLDLEGLVMDREVRALRDSFVTYNYSKLLYNGMYFSPEREFLESSITASQKSVNGKVRCRAYKGTVSILGRSSETEKLYDMSESSMDEIGDFSPAETTGFITVSAIRLKKYGQMKAAAGERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PE30</accession>
    <name>A0A0G4PE30_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S012g000172</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PE30"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL24562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="159" mass="18405" checksum="2B306AD1E102F4BA" modified="2015-09-16" version="1">MERQKVTLRLDTGTKQWPQSSRAKALDACRNYINEFIAATLDPELKQYKWVLNHFNASHSCAILLQDSVQYLNSAEFFDLRQVVESCFEVFSTEPGTDWQKLQKLRMKAWASNQWSFSDPQLDGHLDSFAGLSDWDPWFASLTFGDILRNPLHENLSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PE36</accession>
    <name>A0A0G4PE36_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Crotonase, core</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S012g000133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PE36"/>
    <dbReference type="STRING" id="1429867.A0A0G4PE36"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000081">
        <property type="entry name" value="Enoyl-CoA hydratase/isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF75">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL24524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="272" mass="30418" checksum="65FE91FDEA92E3FB" modified="2015-09-16" version="1">MTTLFTVPISSTGGSIICTNPSTAKEHETIYVLTFTSPPDNRLTPIFIDALLLALDIIEHRYPKGVVVTTSGIVKFYSNGLDLDLVGKTEGFLENWLWRLFRRLLTYPMPTVCLLNGHAFAGGFMLAMYHDYRIMNPDRGFLCVNELEFGVPLQTPMMAIFREKLTPVTFRSVVLEAHRFGGRNALQAGIVDAVGGAEEALALIQTRKLQTKAATGIYGTMKEEMYSRVLSGLDDHAGNLQWREKVEDKNNVVRERSLEAVQQFEKNGKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PEY7</accession>
    <name>A0A0G4PEY7_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S013g000147</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL24904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PEY7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PEY7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.10:FF:000010">
        <property type="entry name" value="60S ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_uL22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_uL22_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593:SF10">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL24904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="184" mass="20555" checksum="F9B9E81FA32F47D8" modified="2015-09-16" version="1">MVRYAAQEISEAKSARARGSYLRVSFKNTRETAQAVNGMKLSKALTFLENVTTKTMAVPMRRYAGSTGRTAQGKQFGVSKARWPVKSAEHIIDLLKNAEANADGKGLDTSALIIKRIQVNQAPKGRRRTYRAHGRINPYMTNPCHIELILTEAAEEVKKATEDKKVRLSTRQRGTQIRRALIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PF21</accession>
    <name>A0A0G4PF21_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S013g000144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL24901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PF21"/>
    <dbReference type="STRING" id="1429867.A0A0G4PF21"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL24901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="357" mass="41167" checksum="D47770541F295A5A" modified="2015-09-16" version="1">MDKKIHTEPEDDIAVDPTTHVTTVYGDDWQSETTSIGSSLYRGLEENGRRYQTLSHKEYLIPSDEKQFKTYEAGHLVALVMDSDYDNPLFRAPVKDPKHILDLGTGLGNWAIDVADMFPTATVRGVDLFPPPVTWMPPNCILEVDNIAEEWTWNEPQDLIHMRIMIGAFDDAEWTRVYQQCYDNIRPGGWIEQLEASPYIDCDDNSLPADSILRSWGPALSACGKRAGRPLETIDMMQDAFRKVGFVDICEKEYKWPIGPWARDQKYKEAGTVNYQHWMSGMEGWAMWLLCKFGAPEPWSQDEVIVYVAKLRAELKNPRYHIYERARRVWARKPFPEEIAEMERVEANKKAGIKVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PFM3</accession>
    <name>A0A0G4PFM3_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial adapter protein MCP1 transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S013g000318</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL25075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PFM3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039960">
        <property type="entry name" value="MCP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012472">
        <property type="entry name" value="MCP1_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38409">
        <property type="entry name" value="MDM10-COMPLEMENTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38409:SF1">
        <property type="entry name" value="MITOCHONDRIAL ADAPTER PROTEIN MCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07950">
        <property type="entry name" value="MCP1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial adapter protein MCP1 transmembrane" evidence="2">
        <location>
            <begin position="180"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL25075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="327" mass="36231" checksum="77885F4F8D95FF78" modified="2015-09-16" version="1">MSSHELSKPEDIDTKSIISLQELDPSPVHDALDVESGEYFPRAASPTQHAAGISIPKLGLSGHRWDSWLTRIQKYSTYPPTAFFILHLANTSLIPLVTRSVPASESYLLLTRPIYQAPGLEHLVLTIPIVAHIASGIALRNIRAGRRARLYGAETRAQRNTLYFWPRMSLQARTGYFVAPLIGFHVWVNRATPLIVEGGSSGVGLGYIAHGFARSPVFWNTFYFFFVTASVWHFVGGWATWMGWRVTTARKERGQKGSLDGYLGLTETKSKRQRKMWWVVNGVAAAGAALWLAGALGIVGRAGEGAGWEAKGWNEMYSHVPIIGEWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PFR1</accession>
    <name>A0A0G4PFR1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aromatic-ring hydroxylase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S014g000049</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PFR1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PFR1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF20">
        <property type="entry name" value="2-MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="10"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="7">
        <location>
            <begin position="464"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL25153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="676" mass="76567" checksum="A539A775BB03213D" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGK0</accession>
    <name>A0A0G4PGK0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S015g000065</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793148">
        <property type="protein sequence ID" value="CRL25479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PGK0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PGK0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051283">
        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF69">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL25479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="509" mass="58159" checksum="F774E87D712EB484" modified="2015-09-16" version="1">MEFFGLKKTITPPTVPTDTIIPFHYYDDTHHNRGLAFDFTFRFDDVLDPRKLQMAFSRLLELGDWRKLGARIRRNGEGKLEYHVPESFDDKRPGFAYSTATFDCKVDDHTQASRLAQPHNLDAEGHPSLLGLSYAATPEFRSFIRVAGFPNYLNDWLHSDSPQIGIRVIIFQDATLVTISFLHSLMDMMGLNTVLDAWITVLCGQEDQVKPFIGFSHDPLAGLKDTKPKLLPKYVFAETLLMGWAWILFALRYILLVEMFWKYREEERMIFLPRKYMHRMRKEAMEELAPQTTSDGKPFFVSDGDVLYAWWTRVVLRAENPSPDRMVNMRSTYCCRSLLADLGHIPSATSALVTNAVSSTLTFLSVRQILERPLSFTASAIREALMQQRNEEQFQAYDAIKKDTLDNANHPALFGSPNMYMIMMSNWAKAKLFEVNFSAAVRDTGMPLDQRKNQSGKPSFILGTGTKSYATKNTGVVIGKDAVGNYWLLYTLHKDVWPAVQQQLLSLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PH05</accession>
    <name>A0A0G4PH05_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SEA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S015g000212</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the wax synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793148">
        <property type="protein sequence ID" value="CRL25626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PH05"/>
    <dbReference type="STRING" id="1429867.A0A0G4PH05"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF67">
        <property type="entry name" value="WAX SYNTHASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="456"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="8">
        <location>
            <begin position="342"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL25626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="528" mass="60075" checksum="9CA5D4699BA57B43" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PHT9</accession>
    <name>A0A0G4PHT9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S016g000231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793149">
        <property type="protein sequence ID" value="CRL25950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PHT9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL25950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="130" mass="14616" checksum="4459C70F7287D3AF" modified="2015-09-16" version="1">MSYYLKNEATNWYDSELTSLEKEALRVLPLEQITYGSHSPIPAPPTKRLPVEETPRLLPPTPSTRIPVPYYPPTWPGGQSSQASTGRSPPEYGYHSSGLSRAVLGGIWSPIFGNHWGYPFMDGREQSHFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PI52</accession>
    <name>A0A0G4PI52_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein secE/sec61-gamma protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S016g000290</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793149">
        <property type="protein sequence ID" value="CRL26009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PI52"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF52">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G11820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="47"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL26009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="492" mass="54686" checksum="5CFF777E5C73105B" modified="2015-09-16" version="1">MQLAEMELNSNKDLEPIHIDDFGARGLSVDYDAAEEQKVVGKCDLHVVPILMLLYLLAFLDRINIGNARLQGLEDDLEMEGPQYNYALFIFFIPYILCEVPCNLIIKKMAPSTWICGIMAAWGCVTIGQGFVKTWGALMACRFLIGLFEAGFLPGCIYLISMYYKRFELQWRLTLFFSASILSGAISGLLAYGLSYMEGVGGYSSWRWIFILEGLATVVIALLAKLLVVDWPETASFLNERERTILLTRLKSENHMFPMDRLDQTAIRRILTDTKIYLGTIMYLGALNTGYAASFFIPSILQGMGWKSLMAQVMSVPIYIVAAIMTLCTAILSDKTKHRSGFVLIGCIVATIGYSILLAQQSVTVGVQYFALFAVTGGGFIAQPIVIGWLSNNMSGHYKQAIASAMQIGFGNCGGFFASNIFLSSEAPFYTTGYGTSLGLIWVCGIAAVIFVLLLWRENKRRDEGARDNRLALDPEEVRNLGDEHPGFRFTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJ76</accession>
    <name>A0A0G4PJ76_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S017g000244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793150">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJ76"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL26261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="98" mass="11426" checksum="AF51C63EB6BA48C0" modified="2015-09-16" version="1">MNVCFICQRMAAGNPTKHRHLRSDPKSYQTEHCVLCSRDFCEAHKSKDESVCEINHQTYYIKHRQIHGIFPSLEARNKQNEQFGFVQQQEMVGDGQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-11-27" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJW7</accession>
    <name>A0A0G4PJW7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endoribonuclease L-PSP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S018g000154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PJW7"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF22">
        <property type="entry name" value="ENDORIBONUCLEASE FAMILY PROTEIN BRT1, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03780)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL26461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="128" mass="13812" checksum="BCA3C076E3D2A64D" modified="2015-09-16" version="1">MSSKTAVLTDKAPKPLPGIYSQAIVANGVVYCSGAVAMDATTGKLIDGDVKAHTHQCIKNLTHVLEEAGTDINKVVKVNVFLSNMDDFAHMNSVYMQYWGDVKPCRTCVAVKTLPLNTDVEIECIAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJY6</accession>
    <name>A0A0G4PJY6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S019g000154</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the GSE complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJY6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJY6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11385">
        <property type="entry name" value="RagC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000643">
        <property type="entry name" value="Small monomeric GTPase (Gtr2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039400">
        <property type="entry name" value="RagC/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF2">
        <property type="entry name" value="GH16429P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL26737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="396" mass="45253" checksum="CCEDE8B0E431940C" modified="2015-09-16" version="1">MSDSPVARVSRPHGPFIGREFNFWRRRREFPFPKTEAELSLLDNLQGNSQVTAPARAKSASVPNTKGPDVKPRLLLMGLRRQSSIASVVFHKMPPNETLFLESTTRIQKDSIHSFMDFQVWDFPGQLEYFESAFDLEDIFGSLGALVWVIDAQDDYLDSVARLNRTILTVQQFYPGINIEVFIHKVDGLSDEYRTDTFQDIVQRISDELSDAGYENAPVHYYLTSIYDYSVFEAFSKVIQKLIPNLSTLENLINTLANNCGFEKTYLFDVLSKIYIASDTRPVDMACYEMCSGYIDVIVDISELYSWDHPVRKRLGDQIQEAESHVVLHDQTMIHLMEMNKYLCLVSVIRNPEAKDKRGLIDMNCRTFQDALNEVFSRSWEEGSAAQEGESATASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PK87</accession>
    <name>A0A0G4PK87_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S018g000277</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PK87"/>
    <dbReference type="STRING" id="1429867.A0A0G4PK87"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056693">
        <property type="entry name" value="DUF7791"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25053">
        <property type="entry name" value="DUF7791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="295"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7791" evidence="4">
        <location>
            <begin position="569"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="170"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL26583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="983" mass="112749" checksum="C00417D88C4DCD2B" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKL7</accession>
    <name>A0A0G4PKL7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S020g000043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793153">
        <property type="protein sequence ID" value="CRL26884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKL7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PKL7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL26884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="174" mass="19439" checksum="52F6400C513FE185" modified="2015-09-16" version="1">MEEHEWKSSTKGSHLRKIDNTLPAAHTRKLYGSQPRNRAYSAQHGPTPSSGCGPCWAEYLFTQLRTGHNWLSTYAKTFDFREDDQYVCGAQETVTHVLVDCPRLRELRRKLRREVGDAFNSVSSLLGGSTEGKKGKPDTVSRAKTVNAVLDFAEASQRFRSRAPRGQPNNGSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PLI3</accession>
    <name>A0A0G4PLI3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S021g000205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793154">
        <property type="protein sequence ID" value="CRL27290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PLI3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL27290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="154" mass="16915" checksum="588DB9AC30C602CA" modified="2015-09-16" version="1">MYVTGGWSTRLVLVSSSSRGASDLPEVSDFLGVATGSLAFATGSLGAGAFGAEDSEESYPDPERRKADMLERKKYQQETSQDPRMHPTRLGYWLAPSWDKRVAPPEGPRWGRADKDPTDKEAMDQLKNDLGITKKHKEDPLSAKTLLPPCLPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PLL8</accession>
    <name>A0A0G4PLL8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S020g000202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793153">
        <property type="protein sequence ID" value="CRL27043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PLL8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL27043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="60" mass="6264" checksum="208EBC716BCD64D3" modified="2015-09-16" version="1">MRIGVMPHLPNRSPGGSNVLIPNTTNDAGQDAVVRAATAHEGKKKANAKAKEKSDQAEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMY0</accession>
    <name>A0A0G4PMY0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S023g000172</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793156">
        <property type="protein sequence ID" value="CRL27714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PMY0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050832">
        <property type="entry name" value="Bact_Acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43877:SF1">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43877">
        <property type="entry name" value="AMINOALKYLPHOSPHONATE N-ACETYLTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="15"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL27714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="164" mass="18578" checksum="C6BCF1936A77D6C3" modified="2015-09-16" version="1">MATILNSTSPPESNLTLDKATVEDIPAIKSMINAAYSKYIERIGKPPAPMTEDWDQVIRTHEVLVLRDNERIVGSITSHEDEQTTSLKIDNVVVNPGEQGRGYGYHMIKHAEVDAKNKGLTSITLFTNVKMFENIGFYTKLGFVETGRRMEDGFERVYFYKKLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMZ9</accession>
    <name>A0A0G4PMZ9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">xyloglucan-specific endo-beta-1,4-glucanase</fullName>
            <ecNumber evidence="4">3.2.1.151</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Xyloglucanase A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Xyloglucanendohydrolase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S022g000206</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>xyloglucan + H2O = xyloglucan oligosaccharides.</text>
            <dbReference type="EC" id="3.2.1.151"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glycosyl hydrolase 12 (cellulase H) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.151" evidence="4"/>
    <dbReference type="EMBL" id="HG793155">
        <property type="protein sequence ID" value="CRL27526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PMZ9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PMZ9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033946">
        <property type="term" value="F:xyloglucan-specific endo-beta-1,4-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002594">
        <property type="entry name" value="GH12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002">
        <property type="entry name" value="BLR1656 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002:SF9">
        <property type="entry name" value="XYLOGLUCAN-SPECIFIC ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01670">
        <property type="entry name" value="Glyco_hydro_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195696" description="xyloglucan-specific endo-beta-1,4-glucanase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL27526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="272" mass="29657" checksum="D47FABFCE729B91A" modified="2015-09-16" version="1">MLFFRQSLPLAALFFTHAASAIPSLGDLSSRAQSSADLCGDYANLILPNTPWIVYNMLYNAAQMVGTQCTNYDAVTTSDNGTKEVLWSSVTNIDYVESTNNVPKGYSFVGLTQNLETKLSVIESIPAAYSWTRTNTTNFKGNICFDFMTNDIKGDSTSSSSHELMLWLQYEGGQLPIGWTNGPAATIDNLFGTSWTLYEDVNTDTGITVSTLMPTKQFEGSFSGDLKDWLLALADLGIFTESTYVNVGNAGTEFFYGNAVMNSTLGLQINLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PND7</accession>
    <name>A0A0G4PND7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Oligopeptide transporter OPT superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S023g000156</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793156">
        <property type="protein sequence ID" value="CRL27698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PND7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="243"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="511"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="595"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="663"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="700"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="741"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL27698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="792" mass="89129" checksum="B54F22DF858BADA8" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PP23</accession>
    <name>A0A0G4PP23_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S026g000005</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the wax synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793159">
        <property type="protein sequence ID" value="CRL28140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PP23"/>
    <dbReference type="STRING" id="1429867.A0A0G4PP23"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF27">
        <property type="entry name" value="WAX SYNTHASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="8">
        <location>
            <begin position="233"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL28140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="420" mass="46761" checksum="733897B5176A1138" modified="2015-09-16" version="1">MSTSSNILKILFLYAAQCLIPATLLIATPKQSILRYLSIPCSIFIVYRAIPVAAALGPGFVWCECGRLFITIAFQCLNLLLINPKDSNDLPYGGSQGFVAQIYAATRFFTDPRGINTPWKIKNAPPQPAYYKRRNMNTPPRGRFLVRQTAIVVWQYLALDVFATLALQQALEQEKIGTLPPVPQWDISTEQWIERIISNIMAGFVVSRILIDFHHRVFSITLVGLGLDSPENCPPLYGRALDADTVRGFWGKFWHQLLQNPLTSVSAFITQDILGLTPRSFVQRYTNVFVVFFCSGGLHLVLDIVQGIPPQESGAMLFFVTAPLGLMIEDVIKAFWKYFSKSNGQSQKLPKPLWQRALGLTWSMAWLGFTSTGFFYPQVVRPENQALVPFSVAGQIGLPIQAGVVLVGGAVLAKVFEVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPG8</accession>
    <name>A0A0G4PPG8_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S026g000144</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="4"/>
    <dbReference type="EMBL" id="HG793159">
        <property type="protein sequence ID" value="CRL28279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PPG8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PPG8"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07000">
        <property type="entry name" value="cupin_HGO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000034">
        <property type="entry name" value="Homogentisate 1,2-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046451">
        <property type="entry name" value="HgmA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046452">
        <property type="entry name" value="HgmA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01015">
        <property type="entry name" value="hmgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056:SF4">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20510">
        <property type="entry name" value="HgmA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase N-terminal" evidence="14">
        <location>
            <begin position="40"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase C-terminal" evidence="13">
        <location>
            <begin position="316"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CRL28279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="489" mass="54887" checksum="E534A5C131B9DB83" modified="2015-09-16" version="1">MSSTDSLSDPEEYQKIFHWAETQKDGTIPSFNTRRNDPYEYQSGFGNAFTSEAIPGTIPHGQNSPRIVRFGLYAEQMTATAFVAPRHCNKKAWLYRVRPAVAHQGFTELSDNKDTEANFLPLNPRIHVSPTQLAWHPFDIPESEEVDFVSGLKSVAGSGDPTLREGLATHVYVANTSMKKKAFVNSDGEFLIVPQQGALDIQTEFGPIFVQPGEIVIIQRGIRFSINLPDGPSRGYILEVWGTQFELPELGPLGANGLANGRDFLSPVAQYEVTQEPWEIIYKLGGKFFRSTQNHSPYDVVAWHGNYVPYKYDLTKFVNVGSISVDHIDPSIFCVLTAKSRDLTAPLADFLTFSPRWDVASHTYRPPYYHRNAASELMGLIYGNYGGRSDEFKPGSVSFECGMVPHGVAYEEFKDATDNTPPAMQISKASIAFMFESCRPFTITDYAWNSKKKHEHEPKMWDSLVDNFSKHAKEVDEILAKKAKNHSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPU1</accession>
    <name>A0A0G4PPU1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S027g000063</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793160">
        <property type="protein sequence ID" value="CRL28374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PPU1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PPU1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF31">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="155"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL28374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="289" mass="31843" checksum="EF12B955CA25F13E" modified="2015-09-16" version="1">MSKVITVFGATGNQGGSVIDAIIADPKLSKEFKIRGITRDTTKKTAQDLVKRGVDVVSADLDAIDSLTAALKGSHTVFLVTNYWETMNADVEYSQGKNVTDVVKAVGVSHLIFSSLHHVTEETKGRLTNVPHFDSKANIEKYIRASGSDMLVRAEDGSYHLFYPVGKQAKFPLFDAAQDTGLFVRAALKHGDQLKNKQILAAAKYYTPDEIVDTFSKVTGKKAVFIQVSPEQYKASLPAAMADEYLDNQLFVEEPGYYLGEPLEPSLSLVDGKPTTWEEFVKKNISTWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQ49</accession>
    <name>A0A0G4PQ49_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S028g000057</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793161">
        <property type="protein sequence ID" value="CRL28504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQ49"/>
    <dbReference type="STRING" id="1429867.A0A0G4PQ49"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051654">
        <property type="entry name" value="Meroterpenoid_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897:SF1">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL28504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="278" mass="31774" checksum="DEEAA29B25EB438C" modified="2015-09-16" version="1">MHPDSQLQDAVTKGFDPKLLYDPNLNHVDEPVRSILEEYSNIPADKILDHVRQLRDRAFKIFPYACIGKFSFLQLSIASSPLYPELLRRTKDGEKLLDLGCAFGQELRRLIYDGAPCSSLYGSDIRPEFLELGCDLFLDHDKMSDQLIGADITDDNSELVVRLKGELDMVYISLFLHVFDWDKQVEVAKQVLDLVTAKPGSLIVCRIMACRDQSAINATLGRMPYYYHDLSSWNRLWEKVQHDTSLQLDVQSWEQPDELAAKHPVEGVYVLGSSIRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQ66</accession>
    <name>A0A0G4PQ66_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S026g000176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793159">
        <property type="protein sequence ID" value="CRL28311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQ66"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL28311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="307" mass="36316" checksum="79AE0899BE89F8BC" modified="2015-09-16" version="1">MTRRTCIPFCNILRVRDPPPRVEPVEPVEPKKFKTLWKIPSEIVDIIFQLLSDLDRACFALSCKRLHACYVSYNRQRGICVLSTLPRTLLLRRLQNERWVYCSRCQNLHRHSRWQFLKFGWRCDPKPAIFECNTWCDFQHDDKVDICPCSSITFHQKQHPIEYFQSQQDTLRRSSYQKLSGTFTHICTIQHPLARVFVLTRARSNKTSKTFQVENEFIFQASKETALSGLFQKISSRLSRYETEFWLKNFFNEAQSNFFIGDKSSNWYQCHGWNIAGGKPYDFKITLHRDLGGDRRPSKGWDGNCHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQ99</accession>
    <name>A0A0G4PQ99_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cupredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S029g000048</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
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        <property type="protein sequence ID" value="CRL28632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1429867.A0A0G4PQ99"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13854">
        <property type="entry name" value="CuRO_1_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13880">
        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
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        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF502">
        <property type="entry name" value="MULTICOPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
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        <location>
            <begin position="19"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="87"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="217"/>
            <end position="350"/>
        </location>
    </feature>
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        <location>
            <begin position="436"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL28632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="594" mass="66568" checksum="6D1477222B6D15C1" modified="2015-09-16" version="1"> </sequence>
</entry>
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        </submittedName>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="179"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL28662.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="418" mass="45426" checksum="5DEAEBBD61540525" modified="2015-09-16" version="1">MKPTKLLDGHGSLYKEVRFSPTETPIRRTKSVSATFPPVISGYGRKAFQDSALVNSFTMDTSYIDQSRALLQSQRLNFETERELFAQERRLWEKERALLRSKIAELEVFVKSQGNRTSQLGSEAAKLVLAGGISQYNTNGLAAQVWEGTSPGNRPTRVFFDHESPDQSYLSPISESGNPPSLDRALSPQSRPVDPSGAPVSQPVPIEKLDSTLDGITLKSTALPPAVVARVITPPSPSPLVTPGTAPSTAARPIMEHRNSLKLKLSELGPPNENLLRHAGHTPMAIIDADDSRSTQEGTPLEAGSQIEEAPLEPVANVHQPTENKISYFPDVPDDPALTGPLGLINDEEHDSNFLSELDQKLLVQAKNILGSSVESADPNETDSESEFPRQGEQDLEIKFKKSTNFGTAFGISNSGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQL5</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Ceppi M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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        <source>
            <dbReference type="EMBL" id="CRL28695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="87" mass="9387" checksum="3C928AB19675437B" modified="2015-09-16" version="1">MSRFNNDLKEGGSTHPNSCKDTACIILQSLQSSASTALWGPALELREQHPKVSQVHLDGLIISDIAQYGSSLATSLSPCLAFWSQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PR77</accession>
    <name>A0A0G4PR77_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
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    <gene>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL28905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="90" mass="10403" checksum="DD25CEACF900781E" modified="2015-09-16" version="1">MERWVEWPTVDDDYGIPGSCIVYVTVLGLVFWRPQLRRIALAALISYWFYYGVWDVSAFPAGLYLAETRLLSEANSADEEFKSPHQSPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRB3</accession>
    <name>A0A0G4PRB3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclin-like F-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S031g000122</name>
    </gene>
    <organism evidence="3 4">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793164">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PRB3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PRB3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="91"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL28954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="376" mass="43072" checksum="506662BDB58FBFEA" modified="2015-09-16" version="1">MKKQVLLSKVRPHGGGKAGGAVSRKMPENHMIRQNTFENQYLLSPDIMSAIKKLSESTYTFLALIDHTLDDIESLCHLDNGHDRRVPCYGLGPLENVPLEILQMILLRLDIRSMTEFRRVNRRARLAVDHIPQYKQIVLHAPASIRGCLSLRSGFSFSCQDLYDKLRTAECDSCGDFGGYLYLVTCRRVCFLCFTEKADYLPLLRSDVIRKFGLRSEHLAKIPSFKSVPGRYSSRGIKCHRRLTLFDHSAAREAGIFVHGDSNSMKQYASESLAKRIEIHQSRNARSTHGVKPPRLPRSEESFDGFSSNPIRFMGIIRAPVLDTRTAIPQWGFHCTACKPHHYGRPLHWRRKFTKDSYRNHIRECGEIIDGKHKHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PS41</accession>
    <name>A0A0G4PS41_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S031g000074</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793164">
        <property type="protein sequence ID" value="CRL28906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PS41"/>
    <dbReference type="STRING" id="1429867.A0A0G4PS41"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF6">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="8"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL28906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="453" mass="50384" checksum="543DC479DC2E50B9" modified="2015-09-16" version="1">MGGPHSKGCLQCIRRKIKCDQTRPECLRCINWGSECPGYNRVHKFKDQTRHITRKHGQPTMDEAFAPNLTHEAINIQTQESFEVWLDYHFPSYLASFNSRVEMNWMNFIRSRWSTFPQALIWAVRALTSLRMGAARSNKEIIACARHMYGRGIKHLAALLHTRAALADETLAAAILLGGYEVLDGSSDRSWIVHSHGIRHLFCARGPSAHTHGIGRTLLLSWRPYLVADAFIHAQPCFLGGFEWACASTTPDISRAKDQWQKTSILGQTMDYAFNEVAKCPGYYAMTKYFTTSDTNADPSMLNALVGCILKSRESLVQLHGMLMETNPPASFVGVIPPTYATTLVQGTRHGINSAIALLDQLMTLLKSCLNRGTKPILAPDFNGKSQEDQWRLFAGLQALKPNTNQSPLSRDSEDPSLAIYAIGDQLDKFSLTMGMGSLSPDACGCPQFSARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PSN8</accession>
    <name>A0A0G4PSN8_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S033g000096</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793166">
        <property type="protein sequence ID" value="CRL29176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PSN8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PSN8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000510">
        <property type="entry name" value="WD repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059122">
        <property type="entry name" value="Beta-prop_WDR5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25175">
        <property type="entry name" value="Beta-prop_WDR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR5-like beta-propeller" evidence="9">
        <location>
            <begin position="152"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="152"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="194"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="237"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="279"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="322"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="418"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="456"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="119"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="456"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="468"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL29176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="513" mass="56172" checksum="4510CA487868C2B6" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PSP5</accession>
    <name>A0A0G4PSP5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histone-fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S035g000075</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
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                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
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        </source>
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        </subcellularLocation>
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    </dbReference>
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        <property type="entry name" value="Histone, subunit A"/>
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        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
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        <property type="entry name" value="CHROMATIN ACCESSIBILITY COMPLEX PROTEIN 1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
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    </dbReference>
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            <begin position="18"/>
            <end position="82"/>
        </location>
    </feature>
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        <location>
            <begin position="106"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
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            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL29380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="187" mass="20362" checksum="A291DD3807F5BA6D" modified="2015-09-16" version="1">MAPKTVGEPDEITGQSALPIARIKKIIQLDEDIVQCSNNATFVIAMATEMFIQYLAEQGHNVVKSERKPRKTVQYKDLASAVSHTDNLEFLSDVIPKTTTYKQFKEKKAKDAANQGAMEKGQRTLNGTGAAPAPENGTATGDDTPQREDSKTTSPSVPRPMVPVSALIADRTVEPVATHDHDVEMQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PTA1</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="102"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="308"/>
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        </location>
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            <end position="482"/>
        </location>
    </feature>
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            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL29343.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="526" mass="59597" checksum="1E1AA441E6BB0FEB" modified="2015-09-16" version="1"> </sequence>
</entry>
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    <accession>A0A0G4PTC1</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Conseiller E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="CRL29630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="125" mass="14469" checksum="6BEA066C7496A33F" modified="2015-09-16" version="1">MSISDIRKEILGNDIAKRIVIKEDDPRALSVAIDLWDDRTFIVVDINHLDYDFNTAHKIKKVFPVYVLRHGKNRGWALIRWPREDESLGAKVMYLHNANGWDVQTPVSSCRRAMTGKRVRVTPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PV04</accession>
    <name>A0A0G4PV04_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Galactose oxidase/kelch, beta-propeller</fullName>
        </submittedName>
    </protein>
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    <organism evidence="3 4">
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DUF4110"/>
    </dbReference>
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        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
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        <property type="entry name" value="Kelch_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063:SF1">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13422">
        <property type="entry name" value="DUF4110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="577"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="654"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL30176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="675" mass="76385" checksum="A3CEB291342CB695" modified="2015-09-16" version="1"> </sequence>
</entry>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
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                <person name="Bensimon A."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="46"/>
            <end position="134"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="CRL30044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
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</entry>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Dupont J."/>
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                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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                <person name="Debuchy R."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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            <end position="46"/>
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            <end position="124"/>
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            <begin position="93"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL30312.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="169" mass="19432" checksum="C9306FEB72DDB52F" modified="2015-09-16" version="1">MDAPEQLSDQDMPDCQPSEMPIQSDEAYPQAVSDPEPPMQQEACPKKPLAIEQFQSTLETLADLDRDDPKLAFQAARTVGLYRRLWASCVPKYREGEKPDNDKTSRETTTKLSNERNGLQHRPDEELSRLYSFEQALGQTQERLIGVLKEWNQCSRSDLAMLMDIKRRM</sequence>
</entry>
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    <accession>A0A0G4PWG5</accession>
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    <reference evidence="1 2" key="1">
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                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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            <dbReference type="EMBL" id="CRL30745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="137" mass="14756" checksum="352F9BBD97523952" modified="2015-09-16" version="1">MSSLRSEDEKNKLREHAVALMSGNDKVRIAPAETTGENDFKYEQWPNVCAVVVDKGSGRGYAQITGGGEEVHAIYTGRGETGYALANISHGIILSCVFSTTNLMRAWHTSREISIAGSSHEISEICLLKNCAVGGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PX96</accession>
    <name>A0A0G4PX96_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BTB/POZ fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S067g000008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
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                <person name="Bensimon A."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793200">
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    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PX96"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00651">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="69"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL31000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="286" mass="32669" checksum="4A265665576F6356" modified="2015-09-16" version="1">MKRNNKKALRENSLCVESIHTVPHAEIEMPEEMTGQIQKIPVGHGTDPGQVVGDITASIQSFFISSQFSDLVIKTEEQEFKLHRLIVCGQSEYFARLYKGNWAETADNTIQLNDDDPRAIEAMIHFMYGIDYDSSGNELGRVSPMIFNVRLYQVADKYFVPQLKQRAKEKFGQIARTCWQMDDFPVAIAEAYQCTQKDDRNLRELLVQISRDHIVELMKSERFCSVLEETVGFAADLVTSLSGERGSTKDHHKYYCSQCSNNWSWCKSGGMHYCPFCGCSGAFRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PY13</accession>
    <name>A0A0G4PY13_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase superfamily, zinc-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S073g000002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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    <dbReference type="STRING" id="1429867.A0A0G4PY13"/>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
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        <property type="entry name" value="ER"/>
    </dbReference>
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        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF294">
        <property type="entry name" value="RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="20"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="342" mass="36503" checksum="2C621DA377A7319C" modified="2015-09-16" version="1">MASAQPTQMKAWLYSSTTNGLEKNLNFDASARAPPAVHGNNVLVQVLSASLNPADYKVPEMGLVGLVAQKFVIGTPASPGMDFCGRVVVSGDDATEFLPGQLVYGCLSQPGQFGSLGEYLVASASLLAPVPEGVEVDHAACIGIAGQTAYQSLAGYVSAGDKVFINGGSGGCGIFAIQIAKEMGCHVTTTCSTKNVEFVRGLGADEVIDYSVEEDLVATLRDRGVVFDHIVDHIGYPAPMYRESHHFLAAGKTFVQVGASGVGTFVDRLIWPSFLGGGKRKYVVFFFKNTREDLVKMGEWVQKGAVKIQLDTAYEFEDAVKAFEKLRSVRARGKIVVHVAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PYB1</accession>
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    <organism evidence="2 3">
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL31483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="56" mass="6683" checksum="5761EB695383A39D" modified="2015-09-16" version="1">MQSLFGMNVNLLETHPGRKWYLLWAGLALLLTGGLWIISRIFPQSDNRLWRKIWDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PZ94</accession>
    <name>A0A0G4PZ94_PENC3</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S4Jg000014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
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                <person name="Lacoste S."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793313">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PZ94"/>
    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL31492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="137" mass="14590" checksum="2FED4EBB384807C8" modified="2015-09-16" version="1">MSQGAPSCISLSSDKVKACATQAWPEVQRYAQGLPKPKISALAPFFPTDACAAPINAAVSELTRAETSIYKTGGFVFFPGKSYVGRKLTLVIPLFMEGETSIAGLAIDMDHFYQVSGKCDVEVSQAAKLVALIVDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NSU5</accession>
    <name>A0A0G4NSU5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BTB/POZ fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S001g000082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
                <person name="Silar P."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="9"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL17122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="356" mass="41795" checksum="20DB8BFBD2343FBE" modified="2015-09-16" version="1">MGFLFATPSDVTLIVIEEPSENDERKKKTALFHVDRSNLIASSPYFERMFSSRWEGSGSHNPTLRGDTIKSMEVMLGVIHGVDTKPETVSVADVWYTIKACNKYQLDPKRLMGWFAQWIKWIDQETPARWENWAFNRQLLFPCYFFDHAEAFQHVSKRLVYNTPGHITEMAPTDSPSFEPMHMPPIVMQQLNAARGRLRTILQRSLFEDANVAIDYAHCNCAARNIFFYMRELHRIGVRPLDSEIHKNCVRDILDRLENFDDDTITNSHPASAQICNACSRSWKRVVEYTRRQVKSYFDGLCLDCMQNHPDENSEYWALDTPRYMYDNTCRIRHGEPTWYFSFMGRRDRNPYRTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NSX1</accession>
    <name>A0A0G4NSX1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S001g000014</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4NSX1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF155">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="33"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="204"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="307"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL17054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="390" mass="42425" checksum="33E2D7698C2496DB" modified="2015-09-16" version="1">MAVTAENLHDDKGPKILAVLWTLTGLTTVMVIARVYIRLKLLRNFGMDDYLIVASMILGIAYCGISTAGVKMGYGKHAMYLSMDNLEMAILLNTVSFLFGILSFTLPKIAVTSMLTRILNPKPLHKTILWMMVGTAAVVSIICILILFTMCDPAEALWKPRPVAAGAKCKSTTMLIDYAIFTGGRSLPLQISAPLGINPVLLAVSALVDLSLAIYPTTVLLKLQMSLRKRIALCAALGLGSIASAMAIIKCTQLHGLADKSDYTYGTADLVMWTNIEANVVVIASCIPTLQPLLEVILGKRALGSYSQGKSDQYKNSSNFPSTFHRSKQSKTHDDLGFTNIDNQESQESILPTDDHGKKSHPLGHIHRKDDVTVEYEPSTPKAGPGYTPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NTR9</accession>
    <name>A0A0G4NTR9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxoglutarate/iron-dependent oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S001g000413</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NTR9"/>
    <dbReference type="STRING" id="1429867.A0A0G4NTR9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:broad specificity oxidative DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051747">
        <property type="term" value="F:cytosine C-5 DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032852">
        <property type="entry name" value="ALKBH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573:SF1">
        <property type="entry name" value="DNA OXIDATIVE DEMETHYLASE ALKBH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="206"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="291"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>substrate</name>
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    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR632852-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL17453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="405" mass="44391" checksum="EC468563CACDC3C2" modified="2015-09-16" version="1">MAKRTLDAFFKPSSATPKRPKTGPIELNSAIPTLDQKNIPIEDTKPPSQHPSYPIPIAQLPSHIAVGLEHATPATAPREINNQPHLDLLHFQPYIPRPTANELFKFLRRELPFYRVQYTARRGDIETQINTPRWTTVFGVDETSTFIQEQDNNPNSLVLLETKTKTPIPKTKYQCTPRPIPACLDLLRRQVEAANAAANADNTTPGYNFCLVNYYGSGEDSIAFHSDDERFLGPEPNIASVSLGGERDFLMKHKPFVSGGIVNRTAGGCVSGTAHAISGLGGTSATRGSCTVSGGTSNSNTVSSPGSRPPATVPLQQIKMSLGSGDMVVMRGATQSNWLHSIPKRKGKTGEATRGRINITFRRAVVPGGTNNYYHYNVGSGGMYRWDEVAREMVLRDSKEYIDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NTZ5</accession>
    <name>A0A0G4NTZ5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin, RmlC-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S001g000404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NTZ5"/>
    <dbReference type="STRING" id="1429867.A0A0G4NTZ5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02234">
        <property type="entry name" value="cupin_BLR7677-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38599">
        <property type="entry name" value="CUPIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G13620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38599:SF1">
        <property type="entry name" value="CUPIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G13620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="35"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL17444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="131" mass="14604" checksum="88524BA5BCA7E43E" modified="2015-09-16" version="1">MEEPTYNPSRPMPSLEIAYSYKLVGIPNRTMVTLRIEFPPNGSTPPHRHGGANVGAYVLKGTVLNKMNEDPMKTIEEGGTWFEAPGCHHRISDNASKTEPATIIATMITETEAFERDGMEALIQIDEPYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NUH5</accession>
    <name>A0A0G4NUH5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S001g000666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NUH5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL17706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="54" mass="5674" checksum="30720379B717904B" modified="2015-09-16" version="1">MALGAQSSPGGLITLSESHARLYRGVELVPVGHLAALRITIEGRMAVQDTQNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NUZ2</accession>
    <name>A0A0G4NUZ2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S001g000845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NUZ2"/>
    <dbReference type="STRING" id="1429867.A0A0G4NUZ2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42070">
        <property type="entry name" value="FILAMENT ASSOCIATED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42070:SF1">
        <property type="entry name" value="FILAMENT ASSOCIATED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL17885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="251" mass="28023" checksum="43CC8ECC188A9CEC" modified="2015-09-16" version="1">MDSTKDQKKNVERLARVRENQRKSRARKQEYVNELEQRLAACKEQAHQKDIEHRLATQKVEAENRHLKALLGSLGVSSASVQQYLQAADTGANTNRKVAIPAIQRVEGENTLSQPRRDTCRSNLSMAVPRVYKKEPETTELPMAVDSTCASTAVQPTYQPPKQTPQEEDPALCGCGSDRQDPETVSDEDVLNSTLCAIAEEMINQYNTKGIDVDEIRRKIWSGFRAGANGTGCRVQNHILFQVLDDISSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NVF9</accession>
    <name>A0A0G4NVF9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S001g000924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NVF9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL17964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="54" mass="5932" checksum="D56EB02788F19CCA" modified="2015-09-16" version="1">MVGLAVAWPRSHTRAAYVDNIGTPTRAIDRGTYLVPSFPSFSIPPNLLITFQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NVQ6</accession>
    <name>A0A0G4NVQ6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNAse P, Rpr2/Rpp21 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S002g000007</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic/archaeal RNase P protein component 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NVQ6"/>
    <dbReference type="STRING" id="1429867.A0A0G4NVQ6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007175">
        <property type="entry name" value="Rpr2/Snm1/Rpp21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04032">
        <property type="entry name" value="Rpr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL18137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="222" mass="24552" checksum="CC6479627EB2B623" modified="2015-09-16" version="1">MAKAKGKKEAKNSKNSQSHIRARLDYLHEAAAYFQGKSTLTEGQNVKVHNNEHTSVAGHVDPEDNGHTVYAQQQVCSVNQKKTQEPLRNLSRVCVSHLRAVAMKTQIRLPVTLKRSFCKRCDTILIPGVTCSHETKNASRGGKKPWANVLVVQCLSCGTEKRFPQTEKRGKKLVERRKEKDSALVLDVNALEVDTPAASQGEAVELCEENVPMLDVADVPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NVR5</accession>
    <name>A0A0G4NVR5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S002g000030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NVR5"/>
    <dbReference type="STRING" id="1429867.A0A0G4NVR5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="121"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL18160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="377" mass="42011" checksum="E5311EB589E37C5C" modified="2015-09-16" version="1">MASQTVAGGNSALHKFRVPAIAQPLHNSIPPELLARYDPIYVAYYNAFNAGRLHTHEIPIEEFRKNPARYTISYGRAPGPDIFRITEQKCPVDGGEITIRIFEPTPQLDDQGQPKKRAAYVNFHGGGWVFGGLAYDHDFCKRVVHGLNGDLVAFDVDYRLAPEHKYPIPVNDCWTAFNWIRTHNATEFHLDPDRFAVGGASAGGQLSAVISHLCRDANIPLRLQVLTVPVTDLHRVFTPEGEFDREGCPYDSYREMEFAPALPAARMAYFHRQFLGVPRPAESNEDWKISPILAPNFQNLAPALVSTAELDPLRDEGEAYAAKLQAAGVFVEIDRIAGAPHLVPVLDGILEGGQRYNEKVIATMKRQLSRDESSTRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWA4</accession>
    <name>A0A0G4NWA4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoside phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S002g000242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWA4"/>
    <dbReference type="STRING" id="1429867.A0A0G4NWA4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056002">
        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7580" evidence="2">
        <location>
            <begin position="209"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="1">
        <location>
            <begin position="590"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL18372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="939" mass="104613" checksum="E4E6DE3AD986C9BA" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWE8</accession>
    <name>A0A0G4NWE8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA helicase, ATP-dependent, RecQ type, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S002g000302</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWE8"/>
    <dbReference type="STRING" id="1429867.A0A0G4NWE8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17923">
        <property type="entry name" value="DEXHc_Hrq1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18797">
        <property type="entry name" value="SF2_C_Hrq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014939">
        <property type="entry name" value="CDT1_Gemini-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055227">
        <property type="entry name" value="HRQ1_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47957">
        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47957:SF3">
        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08839">
        <property type="entry name" value="CDT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="MZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22982">
        <property type="entry name" value="WHD_HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="384"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="607"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL18432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1166" mass="130260" checksum="A843B77D73A27580" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWH3</accession>
    <name>A0A0G4NWH3_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S002g000265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWH3"/>
    <dbReference type="STRING" id="1429867.A0A0G4NWH3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF1">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL18395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="31833" checksum="9EEE6A89D9BC45CF" modified="2015-09-16" version="1">MDSTGIPQSYFTTHPLFLKPVENRIAIWPSEGWTHITDPKERRKVQNRFNQRARRRRQRTVNAHSDSLGHLAEPQTTYIPTTLDDLKSINGLRILGPNSGPSMRTIRHVEILIYAEYTARSPRTELLLGLTQLNFLRALITNMDVLHLSPAQMDDEALSPFNLPTAIQRTVSHHPWLDLLPIPKMRDHLILAGNSVDDVQLCHDLCGYRHSGTGQTGMVVWKDPWDPAGWEVTETFLKTWGWAVQGSWDVFQSTNYWRMKRGEKPLFLLPPEAERLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWJ4</accession>
    <name>A0A0G4NWJ4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glucose-methanol-choline oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S002g000357</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWJ4"/>
    <dbReference type="STRING" id="1429867.A0A0G4NWJ4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF210">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022512"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL18487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
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</entry>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DUF3984"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <begin position="25"/>
            <end position="139"/>
        </location>
    </feature>
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            <end position="248"/>
        </location>
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        </location>
    </feature>
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            <end position="437"/>
        </location>
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        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
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        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
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        <location>
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            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
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        <location>
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            <end position="247"/>
        </location>
    </feature>
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        <location>
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            <end position="327"/>
        </location>
    </feature>
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        <location>
            <begin position="411"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL18752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="453" mass="49217" checksum="A650F4B53816D0B0" modified="2015-09-16" version="1">MESTTLGSFQSRRSYPSLRHISLAPLNPRFPIDDDTDPTDYFNSRDHALPASGTRTPPASSYLSSVSVPSTPPILSHSRSNSRSRHTRSKSSTRVGPLSDTNLHSRDLGHALHHIPNTHKKQTNISYSQGRRPLPDNTPIPKYDAEWMLRAGIALASSTREEKGQSWLSKRETSTSLVLDTPFDETSINRRHNRNKSGTSSRMSRSGASTPGGGALSRAGSRRVSRRGSRVHLTMTTLPAASSTSTPAEREVYMHSGTDTGTVTRTASPDARGRSPLVPDFVDAHIRAEMESLQHRFPDEDSVYWDRAGSDEDETSSEYSCDSDEMPDDFDEADLQQLTRERGFGLGSWIDRLVEWTLFGVDEWPVGVPAATAAAVDASRIGTADTTTTVTFEEPILVDGPDDDALSLGSVGDGGLSDGEGSTGSAASIEKPGSQGGWEDAGWLFRLMKRAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZ15</accession>
    <name>A0A0G4NZ15_PENC3</name>
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        <submittedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein 41</fullName>
        </submittedName>
    </protein>
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    </gene>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:late endosome"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Vacuolar assembly protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057780">
        <property type="entry name" value="Beta-prop_Vps41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 41 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23411">
        <property type="entry name" value="Beta-prop_Vps41"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23556">
        <property type="entry name" value="TPR_Vps41"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps41 beta-propeller" evidence="5">
        <location>
            <begin position="192"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Vps41 beta-propeller" evidence="5">
        <location>
            <begin position="389"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="3">
        <location>
            <begin position="893"/>
            <end position="1068"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
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        <location>
            <begin position="155"/>
            <end position="185"/>
        </location>
    </feature>
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        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
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        <location>
            <begin position="1152"/>
            <end position="1173"/>
        </location>
    </feature>
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        <location>
            <begin position="1214"/>
            <end position="1251"/>
        </location>
    </feature>
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        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="1214"/>
            <end position="1223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23411"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL19298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1286" mass="140900" checksum="569B312C74397715" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZE4</accession>
    <name>A0A0G4NZE4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Beta-mannosidase B</fullName>
            <ecNumber evidence="5">3.2.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Mannanase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PCAMFM013_S003g000232</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyl hydrolase 2 family. Beta-mannosidase B subfamily.</text>
    </comment>
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    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZE4"/>
    <dbReference type="STRING" id="1429867.A0A0G4NZE4"/>
    <dbReference type="UniPathway" id="UPA00280"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004567">
        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000118">
        <property type="entry name" value="Beta-mannosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000050">
        <property type="entry name" value="Beta-mannosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050887">
        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041625">
        <property type="entry name" value="Beta-mannosidase_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041447">
        <property type="entry name" value="Mannosidase_ig"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17753">
        <property type="entry name" value="Ig_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17786">
        <property type="entry name" value="Mannosidase_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="18">
        <location>
            <begin position="12"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="15">
        <location>
            <begin position="193"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosidase Ig/CBM-like" evidence="17">
        <location>
            <begin position="681"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase Ig-fold" evidence="16">
        <location>
            <begin position="785"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF17786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CRL19441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1116" mass="127012" checksum="7C9A515D9E029377" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P009</accession>
    <name>A0A0G4P009_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S003g000446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P009"/>
    <dbReference type="STRING" id="1429867.A0A0G4P009"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051283">
        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF64">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL19655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="512" mass="57387" checksum="401B2411B045C0B8" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P017</accession>
    <name>A0A0G4P017_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S003g000400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P017"/>
    <dbReference type="STRING" id="1429867.A0A0G4P017"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF32">
        <property type="entry name" value="ARGININE METABOLISM REGULATION PROTEIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL19609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="706" mass="79893" checksum="4D619289AED37F3D" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0C6</accession>
    <name>A0A0G4P0C6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S003g000520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
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                <person name="Dupont J."/>
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            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
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        </reaction>
    </comment>
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        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid metabolism; lysine degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid metabolism; tryptophan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.6" evidence="11"/>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P1E6"/>
    <dbReference type="STRING" id="1429867.A0A0G4P1E6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004361">
        <property type="term" value="F:glutaryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046949">
        <property type="term" value="P:fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01151">
        <property type="entry name" value="GCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000003">
        <property type="entry name" value="glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000006">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000008">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052033">
        <property type="entry name" value="Glutaryl-CoA_DH_mitochondrial"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807:SF1">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="16">
        <location>
            <begin position="45"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="15">
        <location>
            <begin position="160"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="14">
        <location>
            <begin position="275"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CRL20140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="425" mass="46033" checksum="1F855E44A02B8474" modified="2015-09-16" version="1">MMNRSLLRAAARSIQAGPTSVAGRRYASSAVFNWEDPLAAAELFTEEELAIQDTARQYCQDKLAPRVLEAYRNEDYDRRILEEMGDLGLLGASIEGYGCAGVSTVASGLITKEVERVDSGYRSGMSVQSSLAMTGIYEFGTEEQKQRFLPGLAKGTVAGCFGLTEPNHGSDPGSMETVAREHPTQKGMYLLSGSKTWITNSPIADLALVWAKLESTGKIRGFIVERERATPGSYETPAIKNKSALRASITGMIHMDNCPVPAENMLPDVEGLKGPFTCLNSARLGIAFGAMGALEDCLARAREYSLERKQFKGNPLAKYQLIQMKLANAATDAAYGTLAAVQVARLKDAGKATPEMISMIKRQNCDRALANSRTLQEVFGGNAASDEYHIARHVANLFVVQTYEGQSDIHALILGRAITGKQAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P1Z5</accession>
    <name>A0A0G4P1Z5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S004g000271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P1Z5"/>
    <dbReference type="STRING" id="1429867.A0A0G4P1Z5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022085">
        <property type="entry name" value="OpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053204">
        <property type="entry name" value="Oxopyrrolidines_Biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797:SF6">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12311">
        <property type="entry name" value="DUF3632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL20331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="294" mass="33864" checksum="04F23B17A7CC0D83" modified="2015-09-16" version="1">MWDEMLKLTRVEESKEFKLFAALVNGDIEVDDAVQWVIATTMDRLENYGPGGTIEKADAITFIAIIELAMQIDTTQYDPLVKFLAELKLYNAVDSSTGLVLKTQDGSRVWSHLPSLTFWAREVWTHQMKYLNDPDMEPEQQIRWAKLNIFLAKVTQAADVEYTSPLQVWISDAMDVSHMALRGLRHVFEEGILSERVASTAGLLGVCYWLICAGDRLWENVLNHRRYNKYDGRPGEMYSHRGWKGFERERWDIWVQGLRDAKATCTPGQELVEDLIDRALAKMERVMKNEIPTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P250</accession>
    <name>A0A0G4P250_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aromatic prenyltransferase, DMATS type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S004g000337</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tryptophan dimethylallyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P250"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13929">
        <property type="entry name" value="PT-DMATS_CymD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033964">
        <property type="entry name" value="ABBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012148">
        <property type="entry name" value="ABBA_DMATS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017795">
        <property type="entry name" value="ABBA_NscD-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03429">
        <property type="entry name" value="arom_pren_DMATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40627">
        <property type="entry name" value="INDOLE PRENYLTRANSFERASE TDIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40627:SF3">
        <property type="entry name" value="PRENYLTRANSFERASE ASQH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11991">
        <property type="entry name" value="Trp_DMAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000509">
        <property type="entry name" value="Trp_DMAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00036">
        <property type="entry name" value="Aromatic_Prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01162">
        <property type="entry name" value="I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000509-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL20397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="419" mass="48221" checksum="B2C26F311C1517E9" modified="2015-09-16" version="1">MTVVNDKMAVRGADKPQFELLDKSLNCPVDDQRDWWQKTGPLLASLMTSAGYTNESQRQHLMFFYTAVVPYLGPYPQKFPSAMTHNELPLELSVNFQQLGGARPVIRVAVEPVTSISGTKEDPYNMSPIRDILSHLEKLNIEGYDPRLFEHFYPKHTLDKIESQKLQQKNESIRELSQVAFGFDLKPDRISVKGYTFPGLKCHLTGKDMCSVVTESIQEYLGDADRYNTIGLMKDYIETTEARANFGFVYSNDCVTPEKSRHKIYGRTKDMSWNQVKEIWAFGGRIDSPESNKGLDYLQRLWELLEIGNGPHPLDLHLVWNYETKAGMKVPATKIYFPVYGLNDQKNVRAIVQYLKEIGLDIRGDAYEQDVQDLFPGFDIQQTDRLICWVSFAYTEKTGVYLSVYYHSSLEYPWLEKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2E7</accession>
    <name>A0A0G4P2E7_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="11">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S004g000363</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9 11">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="11"/>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P2E7"/>
    <dbReference type="SMR" id="A0A0G4P2E7"/>
    <dbReference type="STRING" id="1429867.A0A0G4P2E7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050151">
        <property type="entry name" value="Class-I_Pyr_Nuc-Dis_Oxidored"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912:SF151">
        <property type="entry name" value="DIHYDROLIPOYL DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912">
        <property type="entry name" value="DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 9 11" id="KW-0274">FAD</keyword>
    <keyword evidence="2 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9 11" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="13">
        <location>
            <begin position="49"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="12">
        <location>
            <begin position="393"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="491"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="188"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="225"/>
            <end position="232"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="365"/>
            <end position="368"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="10">
        <location>
            <begin position="86"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CRL20423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="512" mass="54260" checksum="6F49524D2AFAB497" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2Q8</accession>
    <name>A0A0G4P2Q8_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">deoxyribose-phosphate aldolase</fullName>
            <ecNumber evidence="2">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S004g000535</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P2Q8"/>
    <dbReference type="STRING" id="1429867.A0A0G4P2Q8"/>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000044">
        <property type="entry name" value="Deoxyribose-phosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00114">
        <property type="entry name" value="DeoC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF1">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001357">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Schiff-base intermediate with acetaldehyde" evidence="8">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001357-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL20594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="265" mass="28290" checksum="4923C303908CB3D8" modified="2015-09-16" version="1">MSEIPSSDAEWAEKIGNMKKQLPKRSLSQPPIPTQINRTIDHTLLATPIDPTQIDTLCKEALEYDLAAVCVRLEHVARAASHVKGTNTGLACVVGFPEGTHPTAEKVREAKEAVAQGANELDMVIRYNLLKEGRYTEVFEDVRAVRNAAPPPIILKAILEASVLDKDQLIDATIVSCMAGADYIKTSTGWNGGASVEHVTQMGLAASMCGCTCLIKASGGIRNAADLLRMLKAGAQRIGTSAGVNIMKEIDEGEVLEQGCSHSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P390</accession>
    <name>A0A0G4P390_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S004g000718</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P390"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF39">
        <property type="entry name" value="TRANSPORTER LIZ1_SEO1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="65"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL20777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="494" mass="55595" checksum="1801F542EC1AC62F" modified="2015-09-16" version="1">MVFDHTDQLKPTPEVKGQELNAPSEQSEVEPLQQTRRARLKASIWDTWDKSPRERKLVQKVDWWLLSYACTAYFIKSLDQSNTSNAYVSGMKEALDLKGNDLNYLTTYWNIGYIIGQIPSQLILTKIRPSIWLPVLEILWSILVMALAGAKGPKTIFALRFFIGLFEASAYPGIITLLGNWYTPQELAKRSAIFQASSSAANMFSGYLQAALYSGMDGRAGLAAWQWLFIFDGILGIPIALYGFWAIPDSPSDSKTRWLSKEDTEYAEQRMKAVGRAPAAKLTWRTFVDVFRSWPVYLFSTVFIAHVCGLRIYSYFNVWLKSTKRYTVEQVNVIPSAGYGLQIIFTLLYAWTSDYLQMRWPVIVFACVPALVGTIILSVWPAHNTAAMMAGWLLTYVETGAGIIFTSWVSETCGFSAEHRIVVIGVMEAVAFTFNAWVPLLAYNSSQAPHFKVGYQIAAMFFAVELVLTVVIAAVEKRWPARSLVKEKQASTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3E4</accession>
    <name>A0A0G4P3E4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Defective in cullin neddylation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S004g000773</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P3E4"/>
    <dbReference type="STRING" id="1429867.A0A0G4P3E4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF31">
        <property type="entry name" value="DCN1-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DCUN1" evidence="3">
        <location>
            <begin position="54"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU410713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL20831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="269" mass="30663" checksum="DAF5F8429386B1FD" modified="2015-09-16" version="1">MPPYTTSQKHQIAEFVSCTQTKDSVAVKFLKACGWSLPPALDAFFSAASGTSASIASELTKTFDHYRDDPVESPDTIGITRAIDFLGDLKVELDEVTCLAIAELLKSPSMGEFTREGWREGWLGVGCDTIPKMQAHAKLLRERIPQDPSLFRRVYRYAFPLSRMQGQRNLQFEIAAEQWRLFFTTDHGGVAWNTATTPWLDWWIEFLEERGKKPVNKDLWEQVEVFMRKSLEDEEMGWWSPDGAWPGALDDFVAWVQAKRGKGSEMEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3G8</accession>
    <name>A0A0G4P3G8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S005g000030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL20866.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="667" mass="73405" checksum="D54BDCB7B9898FAD" modified="2015-09-16" version="1"> </sequence>
</entry>
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                <person name="Dupont J."/>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
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                <person name="Malagnac F."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
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            <end position="66"/>
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            <end position="198"/>
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            <end position="227"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="235" mass="26081" checksum="1B88C84A22733EDE" modified="2015-09-16" version="1">MSETSIPPDNTREESPREENPQEESPQAQSSARNRALSMSSENPITSSTPAMAPEHPSQQPNTPGSCALRLENLEQQTSTAKGELMISVAADICATFISIAKYSEEGTLQAQHTGVIDNVIQTIRDTDVKQRHLLDRQVRRLRKERNWIRKKYSRLAGQADGLGRAYQTNMRKLSTSLREARGEVARLQSERDMLRACLKKNVPEDVSNDNVDGQGEDVDGEYEVVEGGDGSLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5J2</accession>
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        </submittedName>
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            <taxon>Eurotiomycetidae</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
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                <person name="Lacoste S."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF28">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL21578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="312" mass="35183" checksum="7D3A585159984903" modified="2015-09-16" version="1">MSLIKRARSETTTPFYLYNPSLAVAIVAAVLYTLAFLLTTIQWIRYRAWVWSIMVISAAMEAVGYIGRCVSVQNTLERPVYVLQFSLVILAPVLMAACCYIIFGRILFLIVPQEARTLRLCWVPPRFITPIFVGCDIIALLLQLGGAVMISAVDATDKDAKNKLNTGKHVAQVGVIIQLVAFGMFAVAAVRFNFTCKRFTGSLSERYENVGEKEYIIGGVVKDKNWPTLLRIVNLTTILILVRSIYRLVEFTEGTKGYLSTHEWPLYVFDALCIYPCVSLFVYWHPARYLPYLGFRLPKGAHNSRDSEIGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5K4</accession>
    <name>A0A0G4P5K4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Lysophospholipase</fullName>
            <ecNumber evidence="3 9">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S006g000127</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the release of fatty acids from lysophospholipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the lysophospholipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="3 9"/>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P5K4"/>
    <dbReference type="STRING" id="1429867.A0A0G4P5K4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00147">
        <property type="entry name" value="cPLA2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF40">
        <property type="entry name" value="PATATIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8 9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6 8 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PLA2c" evidence="11">
        <location>
            <begin position="139"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="21"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="570"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="602"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="683"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="578"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="605"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="633"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL21587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="794" mass="87899" checksum="908831ADB1AA539B" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5W2</accession>
    <name>A0A0G4P5W2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S006g000209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P5W2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL21669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="310" mass="35589" checksum="D84C7E6F7213AAD6" modified="2015-09-16" version="1">MVADSELKSFRDIVRNHNRFLVSPLQWTSRHLDLVGSRFEDVATTTVYTQQDRNTDGRNPTLAATDLIQNDTNKKDQEPCSRPLAQSDAEALATSIFPETKRDRLIKILVGKHCAFANISKGPSFFFGGRSVHRPEYIMFHHHKESIDHINNRPPSLLGYVHYTTVNGARYRQFYPCPGPRGATNKVGWSIHRKRLAQTTPEEWTEDPYFVCHLLALAQLQERNLNSSKPITYTSRLLVTNALEREYILFYEAKITTELLSALGNWMDATIPIQWPTIQRKKIPYKPYDTFDSRLKTELGETSTLPSHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P655</accession>
    <name>A0A0G4P655_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">CTP synthase</fullName>
            <ecNumber evidence="3 12">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S006g000337</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>UTP + L-glutamine + ATP + H2O = CTP + L-glutamate + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CTP synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="3 12"/>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P655"/>
    <dbReference type="STRING" id="1429867.A0A0G4P655"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097268">
        <property type="term" value="C:cytoophidium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000207">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000005">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003792">
        <property type="entry name" value="PRK05380.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="CTP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550:SF0">
        <property type="entry name" value="CTP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP synthase N-terminal" evidence="14">
        <location>
            <begin position="2"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase" evidence="13">
        <location>
            <begin position="315"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU810713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CRL21797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="582" mass="64654" checksum="7058462D1E652A38" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6I6</accession>
    <name>A0A0G4P6I6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminotransferase class-III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S006g000477</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P6I6"/>
    <dbReference type="STRING" id="1429867.A0A0G4P6I6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02231">
        <property type="entry name" value="cupin_BLL6423-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000004">
        <property type="entry name" value="Acetylornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005685">
        <property type="entry name" value="PRK07483.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094:SF1">
        <property type="entry name" value="AMINOTRANSFERASE CLASS-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL21937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="652" mass="71211" checksum="59FE81D242F07C22" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6Y8</accession>
    <name>A0A0G4P6Y8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Catalase-like domain, haem-dependent</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S006g000544</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL22004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P6Y8"/>
    <dbReference type="STRING" id="1429867.A0A0G4P6Y8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08157">
        <property type="entry name" value="catalase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000001">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF26">
        <property type="entry name" value="CATALASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="10">
        <location>
            <begin position="8"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL22004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="493" mass="55887" checksum="18795A7EC3CE307B" modified="2015-09-16" version="1">MGDNKYYTLAEGCPFPSNKTTVMIRDRQGGGLGLLQDTQLIETLAHFSRERIPERSYGEFEATRDCSDFTCASFLNKVGKKTPVLQRVSTVGAESGSADTARDVHGWSMKLYTDEGNLDWVFNNTPVFFVRDPIKFPSMNRSHKRHPQTHLPDASMFWDFHVGNPEGIHQLMVLFSDRGTPKSPRYMNSYSGHTYKFTKADGSFKYAKIHVKTQQGIQNFTREEATKIAGENPDYMIQDMFEAIERGDYPVWNVYVQLMTPEEAEKYEVNIFDITKVWSHKDFPLQQIGRLTMNRNPQNYFADIEQAAFSPSTMVPGFAASADPVLQARLFAYPDAARYRLGVNYQQLPTNAAKVQVYCPFQRDGKMRFDHNYGGDPSYVGSSIKPTKFYQDVEGSNPAALYLHTDHEKWAGEVSAYSSEITDADFVQPAALWEIIGRDPGHQDRLISNLVSSVKDVQCPELRKAVYSLFSRVNKDLGLRLQERTEASIKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P757</accession>
    <name>A0A0G4P757_PENC3</name>
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        <recommendedName>
            <fullName evidence="3">CST complex subunit STN1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Suppressor of cdc thirteen homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S007g000075</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P757"/>
    <dbReference type="STRING" id="1429867.A0A0G4P757"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040260">
        <property type="entry name" value="RFA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018856">
        <property type="entry name" value="Stn1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989:SF33">
        <property type="entry name" value="CST COMPLEX SUBUNIT STN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989">
        <property type="entry name" value="REPLICATION PROTEIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10451">
        <property type="entry name" value="Stn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="CST complex subunit Stn1 N-terminal" evidence="11">
        <location>
            <begin position="117"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="167"/>
            <end position="196"/>
        </location>
    </feature>
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        <location>
            <begin position="299"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF10451"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL22094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="366" mass="41698" checksum="20E0326FC207981C" modified="2015-09-16" version="1">MHLSSRCEETENISLGIEQTGKNSSHDLIHIQPRDINPTFNGSSFQSTGYSSNVSFLISPKQDNPEKKDEPMATVNNENLIFYPAFCFKASPTHFTWVKMGAADVHRLRKSSDFVGQNIFFYNNHPIQFVSLVGVIVARTDIPRRTILTLDDSSGATIDIAVLKKTSPKPSTTSQTTPATSQGAPSTSQEKTPWSSFSLTAPTATNLIQETHVTSKDHDEIDISALQPGTVVRVKGTLSTFRSQMQLHLERFWLVRDTNAEMQFLDTRLRFLIEVLSVPWVLTDEEIETLRDDAERCDERALEDKRRAERIAKKKIEREERHAKAIARRYEKEEYERERELRKVREDGERVMRKFGFGGKGEMDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7X9</accession>
    <name>A0A0G4P7X9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S007g000391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793140">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P7X9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL22410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="100" mass="10969" checksum="B0BE6CD1A6CAC00A" modified="2015-09-16" version="1">MHCCPTYTSRTADRQPIPYHQSYFSPSTPDAEPVSPLVNIPPLSQTNTPPSLRVPSPPVCSTGSQGANSALVSCMMRNWHTPCLMAHRPPKVRAFIFCVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P873</accession>
    <name>A0A0G4P873_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S007g000486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P873"/>
    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
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        <location>
            <begin position="23"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="815"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL22505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="856" mass="96075" checksum="06B0E9FAE431C4AC" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P8T1</accession>
    <name>A0A0G4P8T1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA mismatch repair protein MSH5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">MutS protein homolog 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S008g000113</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P8T1"/>
    <dbReference type="STRING" id="1429867.A0A0G4P8T1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P988</accession>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
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                <person name="Debuchy R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL22876.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="360" mass="38995" checksum="EA20F05C900EC04D" modified="2015-09-16" version="1">MSRLPTPAMSGGFIIKDKPDGDAFTLPPAALSTGSRRSSRSDPSYIPASPTSPELSGRRTSHTARSGTSIKRPLEDFDLPPPPTRTRKIIQMKPKSPSKPPKTRENGKGSQSSEDAMPNPTSNSKRKQPSATSAAGRKIARKTAHSLIERRRRSKMNEEFGTLKDMIPACTGQEMHKLAILQASIDYVNYLEKCIRDMKTGGSTQTPAAPPSPTSPEFIAETGEPIQMERERSSTYSYSTSASPELYAALTEFPDTSPSFSPRTQVPSAHIPQDASSILPSPALGPIWASSEKMVEFQGVDHEASAALLMLTQDRRGTADSISENFPGSTTLAQSVEDTPAVPLEIQRRKGMSVRDLLIS</sequence>
</entry>
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        <submittedName>
            <fullName evidence="7">Fungal transcriptional regulatory protein, N-terminal</fullName>
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        <name evidence="7" type="ORF">PCAMFM013_S009g000132</name>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Dupont J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="19"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="324"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="358"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="492"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL24055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="551" mass="62128" checksum="D21B1594B1D57D6C" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCQ8</accession>
    <name>A0A0G4PCQ8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PLC-like phosphodiesterase, TIM beta/alpha-barrel domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S011g000124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PCQ8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PCQ8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08586">
        <property type="entry name" value="PI-PLCc_BcPLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF113">
        <property type="entry name" value="SI:DKEY-266F7.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidylinositol-specific phospholipase C X" evidence="1">
        <location>
            <begin position="158"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL24130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="471" mass="53477" checksum="F5D846BE57A45C84" modified="2015-09-16" version="1">MVAEHLTIRNNTSTPIVLKRIERFPAPEKDGFNAFSTMARNLTQVLTNQTRNEEVSSIEQDSRPFEEKDFDIHVEPFATKKTELRSFIHSDKERMRLTFEAEGQKYQIQAPVPTTESAGMKALNENPKHRFTGIFVVPESFLAIFSSANLNAWMRELRDDTLVSALSIPGTHNSPTCHIAPPSVRCQAVSPKEQLENGVRFFDIRVQPQYPDDAARDELILVHSAFPISLTGNKYFRDLMREVDGFLERNPSETLIVSVKREGTGNATDEQVSRILHDHYAKAGSRWWVRPKIPTLGEARGKVILMRRFNLQQKLKDEHGGNGWGIDAAAWADNTPNAKCPSGQLCIQDFYEVLESMNIEKKIKFVSEQIDRASCCRYPFGVQPDMHATKAFPFYVNFLSASNFWKTDTWPEKVAAKVNPAVVDYICRRGKEHDADCSTGILVTDWVGLNGDWDLVRCIVGMNAKLRLRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDC8</accession>
    <name>A0A0G4PDC8_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">sterol 14alpha-demethylase</fullName>
            <ecNumber evidence="12">1.14.14.154</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">PCAMFM013_S011g000306</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>32-hydroxyeburicol + reduced [NADPH--hemoprotein reductase] + O2 = 32-oxoeburicol + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75431"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:194328"/>
            <dbReference type="ChEBI" id="CHEBI:194329"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:75432"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>32-hydroxylanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 32-oxolanosterol + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75107"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:166681"/>
            <dbReference type="ChEBI" id="CHEBI:166806"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:75108"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>32-oxoeburicol + reduced [NADPH--hemoprotein reductase] + O2 = 14-demethyleburicol + formate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:75435"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:194329"/>
            <dbReference type="ChEBI" id="CHEBI:194330"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:75436"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>32-oxolanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:75111"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17813"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:166681"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:75112"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a 14alpha-formyl steroid + reduced [NADPH--hemoprotein reductase] + O2 = a Delta(14) steroid + formate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:68068"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:138031"/>
            <dbReference type="ChEBI" id="CHEBI:176902"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:68069"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 14alpha-hydroxymethyl steroid + reduced [NADPH--hemoprotein reductase] + O2 = a 14alpha-formyl steroid + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68064"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:176901"/>
            <dbReference type="ChEBI" id="CHEBI:176902"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:68065"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 14alpha-methyl steroid + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = a Delta(14) steroid + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54028"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:138029"/>
            <dbReference type="ChEBI" id="CHEBI:138031"/>
            <dbReference type="EC" id="1.14.14.154"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:54029"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 14alpha-methyl steroid + reduced [NADPH--hemoprotein reductase] + O2 = a 14alpha-hydroxymethyl steroid + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:138029"/>
            <dbReference type="ChEBI" id="CHEBI:176901"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:68061"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>eburicol + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = 14-demethyleburicol + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:75439"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:70315"/>
            <dbReference type="ChEBI" id="CHEBI:194330"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:75440"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>eburicol + reduced [NADPH--hemoprotein reductase] + O2 = 32-hydroxyeburicol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75427"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:70315"/>
            <dbReference type="ChEBI" id="CHEBI:194328"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:75428"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>lanosterol + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:25286"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16521"/>
            <dbReference type="ChEBI" id="CHEBI:17813"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.154"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:25287"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>lanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 32-hydroxylanosterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75103"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16521"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:166806"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:75104"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 25">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 26">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.154" evidence="12"/>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PDC8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PDC8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:heme binding"/>
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        <property type="term" value="F:iron ion binding"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="P:mycotoxin biosynthetic process"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="Cyt_P450_CS"/>
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        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
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        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 25 26" id="KW-0349">Heme</keyword>
    <keyword evidence="9 25 26" id="KW-0408">Iron</keyword>
    <keyword evidence="11 27" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 25 26" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 26" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 26" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 27" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 27" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="25">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038974"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047587"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047670"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048479"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048866"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049450"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00051540"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00051806"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00052067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00052625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="CRL24312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="516" mass="58310" checksum="DA9E7CC6DC98F1F3" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDV4</accession>
    <name>A0A0G4PDV4_PENC3</name>
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        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S012g000080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040410">
        <property type="entry name" value="UPF0658_Golgi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391:SF1">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL24471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="349" mass="39854" checksum="8988C0647FBA1602" modified="2015-09-16" version="1">MYRPTTTNQWWFCGQLFVQAILSLAVATYILIEWQSWVTPLITQVTVSYTVPIGLGIVIFAVLFTFFLSLDAIHHQNNALLIAICICNTCTLVFSIMRYSSIRGITNGLYLSRYRKPILVDTSRNLWPRIQPAEIILSVIVGVSSLSLWLCAYFLHKEFSWTIYKSVHGSLQTRKRYRAYEIYIVLIKLIFFFLTGFILQYNLIDVHFDEPEYSLTMALIPAAFIMIMLGIYFVKHEKTYPMIPILLCYLGLIAYLISRIVLLCGHTRRANTAGKDMMLLFAFAALVSTLSTFCCAVVCVLNFNNGLKGVDKWRKQVARESSLFHSGGYRPAGYDLPSHSQSLPRLSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PE14</accession>
    <name>A0A0G4PE14_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S012g000152</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PE14"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009141">
        <property type="term" value="P:nucleoside triphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16018">
        <property type="entry name" value="Enpp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.180:FF:000003">
        <property type="entry name" value="Type I phosphodiesterase/nucleotide pyrophosphatase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF120">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="596"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="625"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL24542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="725" mass="80914" checksum="6B9BD2817090A452" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PEC8</accession>
    <name>A0A0G4PEC8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S012g000283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PEC8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021276">
        <property type="entry name" value="DUF2855"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11017">
        <property type="entry name" value="DUF2855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL24673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="441" mass="48446" checksum="FAE9E6743219ACF0" modified="2015-09-16" version="1">MSVHVVSKLDNRQHARFNLEAAAQRELADSSVRIRTQLISLTSNNLTYARMGGFLRWWDTYPVSEDYPAPYNDPSAWGIVPAWGYATVEETTIPEIPKGTLLYGFWPTTSTPTDLKLKRGSPEGHWIETSEHRQQLMPLYNRYTVTPTTTPVSELTTTVKPLSDSAKDELDRMAWTTLFIGGVAGFVLSEYVFSSNPNQPPIHPLGNQAGLQWTLSDGELSSAVVVNLAASTKTARVFSYYLSRKPDSSAPLGLLQVTSTVSRIEEADRNLPTSVPSKVVAYGDVDSKESAEWLASRRPSKIVVVDFGGRGNAVKDTLSLIKNTAELKDCKVVIVQVGNEQKVYSTEEIIAGQAAMAELGKVQYNTSGVQDTILETVGPEAYFATRDAQWEKWLDERHLSEPGTKIVFGSGVSGADGVEGGWERLCHGQVGPEEGLVYKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PFN1</accession>
    <name>A0A0G4PFN1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S014g000012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PFN1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PFN1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL25116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="246" mass="26800" checksum="CC35B1886CDE9F70" modified="2015-09-16" version="1">MASNPPAACCAIGIKHEGEAKGQLQQIGDVEVYISHPERSTKRAILLLTNVVGHRFINAQLIADQLTANGYLVVMPDLFHGDPMPLNNCPASFDLMSWLKGPPGHLPDRVEPVVQAILKEMKSNMGCERVGAVGYCFGAKYAVRLLQPGLCDVAYVAHPSFVDAEELQAIQGPLSIAAAETDSIFPASKRHESEDILAKTGQPYQINLFSGVEHGFAVRADITNPIIRFAKESAFLQALAWFDQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PG25</accession>
    <name>A0A0G4PG25_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase II subunit RPB9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DNA-directed RNA polymerase II subunit 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S014g000169</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PG25"/>
    <dbReference type="STRING" id="1429867.A0A0G4PG25"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001193">
        <property type="term" value="P:maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10508">
        <property type="entry name" value="Zn-ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034012">
        <property type="entry name" value="Zn_ribbon_RPB9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="13">
        <location>
            <begin position="130"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CRL25273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="170" mass="18283" checksum="F5C0461E980C6E53" modified="2015-09-16" version="1">MSASPSSTTGGDTKPSDQIHFKFCRECSNLLYPKEDRVNNQLMFTCRTCHVGEPASSHCVYQNHLHSQVGDTAGVTQDVTSDPTVCLPGLCTLCGDIISCSICDPAPNEDIPEDAPPVGDSLESSGLPRANKLCPSCGETEAVFFQSQQRSAETGMKLYYVCCACGQVYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGU3</accession>
    <name>A0A0G4PGU3_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Cytochrome c oxidase subunit 6, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Cytochrome c oxidase polypeptide VI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S015g000078</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome c oxidase subunit 5A family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793148">
        <property type="protein sequence ID" value="CRL25492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PGU3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PGU3"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00923">
        <property type="entry name" value="Cyt_c_Oxidase_Va"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.40:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.40">
        <property type="entry name" value="Cytochrome c oxidase, subunit Va/VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003204">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036545">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200:SF11">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02284">
        <property type="entry name" value="COX5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48479">
        <property type="entry name" value="Cytochrome c oxidase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0349">Heme</keyword>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CRL25492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="158" mass="17925" checksum="566ED3FD82B7F742" modified="2015-09-16" version="1">MSSLSIFRVATRAVRPTGFFRAPQLTRSRMQSPVTLAAARAHNFGTTSMLRSGHEDETYEEFTARFEKEFDGVQDVFELQRNLNNCFAYDLVPSVEVLTAALKAARRVNDFPTAVRVFEGVKAKVENPDQYKQYLESLEGLRVELGVALREELYPQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGX9</accession>
    <name>A0A0G4PGX9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S015g000076</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793148">
        <property type="protein sequence ID" value="CRL25490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PGX9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PGX9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22572">
        <property type="entry name" value="GCP5_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059169">
        <property type="entry name" value="GCP5_N_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032797">
        <property type="entry name" value="Mod21_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF33">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14609">
        <property type="entry name" value="GCP5-Mod21_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-Tubulin ring complex non-core subunit mod21 N-terminal" evidence="8">
        <location>
            <begin position="68"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="9">
        <location>
            <begin position="235"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="616"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="785"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="797"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL25490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="878" mass="99388" checksum="70B094D6EA142BB9" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PHC1</accession>
    <name>A0A0G4PHC1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AMP-dependent synthetase/ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S016g000056</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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    </dbReference>
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    </dbReference>
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            <end position="418"/>
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            <end position="544"/>
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    </feature>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="Pfam" id="PF13193"/>
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        <source>
            <dbReference type="EMBL" id="CRL25775.1"/>
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    </evidence>
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</entry>
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                <person name="Renault P."/>
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            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">FM 013</strain>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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            <dbReference type="EMBL" id="CRL25801.1"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
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</entry>
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    <accession>A0A0G4PHS8</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Dupont J."/>
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            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">FM 013</strain>
        </source>
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    </dbReference>
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            <end position="124"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
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        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL25927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PIA8</accession>
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        <submittedName>
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        </lineage>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Dupont J."/>
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                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NDUFAF6 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PIA8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PIA8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000026">
        <property type="entry name" value="NADH dehydrogenase (Ubiquinone) complex I, assembly factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21181">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21181:SF13">
        <property type="entry name" value="NADH DEHYDROGENASE (UBIQUINONE) COMPLEX I, ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL26122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="391" mass="42761" checksum="978BDBDA100ECC76" modified="2015-09-16" version="1">MSFLGTARPCQASSACRFHLRSFQSQKRHFSRTQSIAAPITAEEVQGAHKYCVALLSKYDRPSYTLSTFIPRHAQSFYIALRALNVSLSMIPDTTSSPTIGLMRLQFWRDSVTKILAGTPPKEPVAILLASAISELHERTQGRARISKGWLTRIINSREQTLTNDPYPNIAALESYAENTYSTLMYLTLSALPMASVTADHVASHIGKAVGIAAVLRGLPFVAFPAPSAQAPPGIGAGSAIGGGAKQGAVMLPLDVMAQAGVKEEDVLRYGAQAEGLRDAVFTVATRASDHLITVQQMLSNLRAGEDVGHDFEHEGEEGHEYDVSPGARSGESPLDEVNRAFGVFLPAVGTRMWLDRLQKQDFDVFSPELLRSDWRLPWKAYSAYRRKSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PID7</accession>
    <name>A0A0G4PID7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Coatomer, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S016g000237</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793149">
        <property type="protein sequence ID" value="CRL25956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PID7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PID7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026740">
        <property type="entry name" value="AP3_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037096">
        <property type="entry name" value="AP3_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="7">
        <location>
            <begin position="85"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="615"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="757"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="621"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="640"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="768"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="778"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="790"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="828"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="879"/>
            <end position="890"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL25956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="890" mass="99680" checksum="A9B0FE270E3CC444" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-11-27" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJB6</accession>
    <name>A0A0G4PJB6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD-dependent pyridine nucleotide-disulphide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S018g000193</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJB6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJB6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF3">
        <property type="entry name" value="FERROPTOSIS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="9"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL26500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="416" mass="44397" checksum="3C92FED771538E23" modified="2015-09-16" version="1">MSQDSSKKNLVVLGGSYGGISTAHYLLKHVVPRLPNKASYQVVLISTSSQAICRPACPRALISDDMFPQEKLFVSVPQQFEQYPKDSFRFIQGTVTKLDHHDRYTTASLKDGNTEKIAYHALVIATGTSTASPLLGLNSDSESLRATWKTFREALPNAKHIVIAGGGPTGVETAGELGEYLNGRAGWFGSKLENPKVTITLVTASSKILPVLRPAIAKKAENFLAQVGVTVVTGSRIATVTPTGAGTESALATNATVTLEDGKTLEAGLYIPATGAVANTSFIDESLLTASGSVETNVSTLRVDKAGARVYAIGDVGSHARPAVHNILNTVPILCANIKRDLLISEGKEEGAVGADRVFKEDTRETQLVPIGKSKGVGAAMGFQLPSLFVWLIKGRDYWLWTTGDLWSGKQWAKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJI9</accession>
    <name>A0A0G4PJI9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S018g000014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL26321.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="281" mass="31985" checksum="3C00336749EF9FAE" modified="2015-09-16" version="1">MAETQGSYDLSLDGSFLKDLPPLIKRYMYHGKSQFFDILQTESAQFESSIKSSEFILFHASKETIQTIFDPRNEDETPSISKLCTSFDTKEQLLLVTMPSDPHSAAANAVNTMILQTLIPMGLMNALRGSPGATVQGQDRGKQPDYGWGPRRKVPGQPRNPSVTLEVAYSESDTKLNSDVRFWLSPDDGNANICLTLRIDRSRPQIRIESWERRNGQAHRTQVIWVTKKGKQPNVTGYPLLIPFESLFRYQPTCPKEKDLEISQEQLEEIATMIWEVQWDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="3">Str. FM013</fullName>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793152">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJR8"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL26675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="275" mass="29231" checksum="55E3DD452D5E2138" modified="2015-09-16" version="1">MTATTPLALTTTFSPPPACTTDTCREGWYLSQGPTDWSSCFPSGYEATTAFYYSPGVCPSGYSIADSTVLSIGSSSETRATCCPSSFTAQPGDDMVWYSTNRCYSDNTDTNHVWTFTQGGTITSKTMSGGLNAKAVFVRWQYTDFQTTATTTTDSKATSTGSTARNAVSSSGPLATATTPSTGQSGSSQGGSSRAWIAGPVIGVVVGCVLIALAATWYNRRRWRQKGPTGAELPVKPSTEPPHDMAELYQEPKVFEAPCKPAYSGPFELSTTQHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PK96</accession>
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    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
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        <lineage>
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            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
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            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PK96"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42044:SF2">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42044">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
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        <property type="entry name" value="P450"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
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            <end position="112"/>
        </location>
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        <location>
            <begin position="517"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="838"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL26794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="882" mass="99945" checksum="DF0C44EC4FD0DFF8" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKB7</accession>
    <name>A0A0G4PKB7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AMP-dependent synthetase/ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S019g000244</name>
    </gene>
    <organism evidence="5 6">
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="pathway">
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    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
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    </dbReference>
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        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="FACL_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Long-chain-fatty-acid--CoA ligase FadD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF6">
        <property type="entry name" value="ACYL COA SYNTHETASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
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    </dbReference>
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        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="48"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="482"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL26827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="584" mass="64136" checksum="16405E8CFCD485E7" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKS2</accession>
    <name>A0A0G4PKS2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S020g000103</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CRL26944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PKS2"/>
    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
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        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF77">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
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        <location>
            <begin position="107"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="756"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="756"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL26944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="843" mass="94031" checksum="91BB6554511FB94B" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PL54</accession>
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        <submittedName>
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            <taxon>Eurotiomycetes</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Lacoste S."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
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    <comment type="similarity">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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            <begin position="24"/>
            <end position="85"/>
        </location>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00043970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL27160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="119" mass="12659" checksum="EC5C9BE861990348" modified="2015-09-16" version="1">MRVTSILSGTARTPLIRFVGKRTVPQSIDHSPRVHPASPTGSLPDSFATYRAKAQQHGPLGRSSFNATIGGHSGASLGPVKPQTGEFFDRAELPSRFGRLPWTQAEIDAIETGGASMFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PL66</accession>
    <name>A0A0G4PL66_PENC3</name>
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        <submittedName>
            <fullName evidence="11">Sugar/inositol transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S021g000087</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
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            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
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        <property type="protein sequence ID" value="CRL27172.1"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:carbohydrate:proton symporter activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
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        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF21">
        <property type="entry name" value="QUINATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="390"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="29"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL27172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="530" mass="58120" checksum="F177FFF7F497E48C" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PM02</accession>
    <name>A0A0G4PM02_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent rRNA helicase RRP3</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP-dependent rRNA helicase rrp3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PCAMFM013_S021g000128</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent rRNA helicase required for pre-ribosomal RNA processing. Involved in the maturation of the 35S-pre-rRNA and to its cleavage to mature 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 24">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with the SSU processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="HG793154">
        <property type="protein sequence ID" value="CRL27213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PM02"/>
    <dbReference type="STRING" id="1429867.A0A0G4PM02"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17954">
        <property type="entry name" value="DEADc_DDX47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DDX47/Rrp3_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF20">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 17 22" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="21">
        <location>
            <begin position="75"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="106"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="306"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="467"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="75"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="475"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CRL27213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="497" mass="54071" checksum="BC54E1EFA20ED994" modified="2015-09-16" version="1">MPITKKRKVAHAAPAAPVEDSDAASNASSSSPQATAADSDVEDSASDSNPQPTADDPNVEDASSETEPSASSAPKTFKELGLIDSLCEACDKMGYKAPTPIQSESIPLALQGRDIIGLAETGSGKTASFVLPILQALMEKPQPFFGLVMAPTRELAYQISLACESLGATINVRSTTLVGGMDMVPQSIALGKKPHIIVATPGRLLDHLENTKGFSLRNLKFLVMDEADRLLDMDFGPILDKILKVLPRERRTFLFSATLSSKVESLQRASLSNPARVSISSSKYATVETLQQTYILRPYKHKDIYLVYLLHEFIGQSVIIFMRTVHETQRVAFLLRGLGFGAIPLHGQMSQSARLGALGKFRSKSREILVATDVAARGLDIPSVDCVLNFDLPTDSKTYIHRVGRTARAGKSGTAISFVTQYDVEIWQRIEAAMGKELDEYPAPKDEAMVFAEQVSASQRDAIQAMKHYDEKKGAKGKGKFSFKGKRSRDAMDQEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PM84</accession>
    <name>A0A0G4PM84_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Isopenicillin N synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S022g000210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793155">
        <property type="protein sequence ID" value="CRL27530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PM84"/>
    <dbReference type="STRING" id="1429867.A0A0G4PM84"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000006">
        <property type="entry name" value="2-oxoglutarate-Fe(II) type oxidoreductase hxnY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
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        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="179"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL27530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="347" mass="39147" checksum="A13F9D0C1A02842F" modified="2015-09-16" version="1">MSLPAAPPILDFSPFYGKDSDAKTKLIDDIRKCCHYNGFFQITGHRVPLDLQRRVMDCSRRFFDLPLEEKLKVDKNLTTFNRGYELLRSQMLEVGTGPELKEGLYIGEEIPEDHPYYLEKKLNSGPNQWPPTVPNKEEFQETTMEYYHATFDLAKDVLGVLAQTLGVESTFFDPLTDGAVATMRYLHYPAQPQDTDEKLNRGIGAHTDFGCITLLLQDEVDGLQVLDAPSGQWLDVKPVPGAYVVNLGNLFMRMANDKYKSNTHRVINKFGRERYSIPFFFSGNPDYICECLPNCREEGEPAKYGPITVQDMVTASYKESYGRAEAFKKDLGLKKADVIPAVAAVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMI0</accession>
    <name>A0A0G4PMI0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S023g000108</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793156">
        <property type="protein sequence ID" value="CRL27650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PMI0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PMI0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF2">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="104"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="469"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL27650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="554" mass="63948" checksum="4C65CA886F77C90B" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMR0</accession>
    <name>A0A0G4PMR0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S023g000102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793156">
        <property type="protein sequence ID" value="CRL27644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PMR0"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL27644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="46" mass="5380" checksum="730E399A8EA19636" modified="2015-09-16" version="1">MMSHRGYGEMVVEREKAGGRREEEEEKRKKEYTASQDIVIVIVILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNR6</accession>
    <name>A0A0G4PNR6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S024g000046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793157">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PNR6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL27791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="52" mass="5879" checksum="2C1227C44ACA2A90" modified="2015-09-16" version="1">MMALELSSYLWIKFLWVPFISPVEYNRGSSSPTDGSTEKKNARNERKGPSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNT0</accession>
    <name>A0A0G4PNT0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S025g000107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793158">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PNT0"/>
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    </dbReference>
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        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL28049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="217" mass="23376" checksum="E54BA61B9C7BBAB4" modified="2015-09-16" version="1">MTSILPRISAEFETLDELTMRGRVFPASQRGPAMIMSPGQRGIINLVFDPRGLGASDGHPVPAPSDTKLALWGLSLGSNVPHAATAFDKRVTATIAIVPLIDSTGIPEKRQPILELAIHDRASRLDSEDPMRLSYVNKDETQGDSHFGDDDIILNKQLDFLKRGLDLGGLSDEYYIHPVNGFKAVAIFPIEVSTGSGDAQPGHRGHSTGGANARTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPS4</accession>
    <name>A0A0G4PPS4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S027g000048</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in cell wall morphogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Lipid-anchor</topology>
            <topology evidence="1 8">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="EMBL" id="HG793160">
        <property type="protein sequence ID" value="CRL28359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PPS4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PPS4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000038">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF11">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005118129" description="1,3-beta-glucanosyltransferase" evidence="8">
        <location>
            <begin position="18"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="9">
        <location>
            <begin position="376"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL28359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="539" mass="57114" checksum="9D6A07919048F605" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PR74</accession>
    <name>A0A0G4PR74_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Epoxide hydrolase, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S031g000082</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793164">
        <property type="protein sequence ID" value="CRL28914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PR74"/>
    <dbReference type="STRING" id="1429867.A0A0G4PR74"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF39">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="3">
        <location>
            <begin position="13"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL28914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="200" mass="22470" checksum="CF339B534FE751A4" modified="2015-09-16" version="1">MTIQDLWLRSYVTKGRINSFPHFTTDVNAVNIHFVGIFPQKKDAVPILLIHGWPGSFLEFLPILQKFKDEYTPETLPYHLIVPSLPGYAFSSGTPLDRDFSTGDVAGDDIGSRIARNLGVDHESCKVNLVLMKCPDNMTDDHLNAYEIEGVEKMQYFMAFGSGYATEQGARPSTIGHVVSSSLLALLARSIPKYRRQYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRD2</accession>
    <name>A0A0G4PRD2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S030g000005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793163">
        <property type="protein sequence ID" value="CRL28718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PRD2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PRD2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL28718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="335" mass="37394" checksum="7C51F66EF54F21FF" modified="2015-09-16" version="1">MTERWQNPGGWGARHMNDTAPFTLWDDLNRKYRLPTEEEYQWASNKFGYRSLMMSGWLICIETNNPPNPVPLTVGCMPAIFIGINETFHEPSPNAPYGNPRVPDPCPHLRLPHPSPNGPYSNPRVPDPCPHLHLPRMEFPTDADNVAVLKALEPLANIRAVVYLPWWTVVELVYGDNRVYGPRSLPGTVAGRTTIYHHEEAPFYSSMKNLTAARRLDLAQQEEPPRMLLQGKHIKAGSWAEVYGVSSGLVSLMSYGKLFQKPTPGCPYIPFDQWHSYNIQACWGAVDEAISDGIGGAPIVSCENGGVTGFFHLFDGMDCLSAHLDELVAEGWEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRW2</accession>
    <name>A0A0G4PRW2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S033g000109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793166">
        <property type="protein sequence ID" value="CRL29189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PRW2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PRW2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="69"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL29189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="232" mass="26129" checksum="3B8CAF597AF473AD" modified="2015-09-16" version="1">MDLIKYAAEADGPGLAKVNVQSFQGRRLLEELFPEASLTRMQEYKIVVGMKHLANPNMHVLKIHDPVSKELATYSRWQFPASFGPSLVTLSEKAALLAKDPLPHAPRPMNEEVFNAFKKLLEDGRKRYTTENDIILDLLATLPEYQGRGFGSAILKWGTNKADASQSRIFLEGTPEGVPVYLKHGWKILEEVVMDYTLFGSVGQESFFLMMRDPVSQSGVQVSYYTPYIVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PSB7</accession>
    <name>A0A0G4PSB7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cell division/GTP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S032g000084</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793165">
        <property type="protein sequence ID" value="CRL29048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PSB7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PSB7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000196">
        <property type="entry name" value="Cell division control 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="89"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="409"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="409"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL29048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="465" mass="52698" checksum="C9901D23B39B811B" modified="2015-09-16" version="1">MSSPPASSSPVASPVASRDSVTPNNGLESPFVERSNPMGSGIAQTVSSRDPKAAAQAATDMKNVVRRKLTGYVGFANLPNQWHRKSVRKGFNFNVMVVGESGLGKSTLVNTLFNTSLYPPKERTGPNADIIPKTVSIQSTSADIEENGVRLRLSVIDTPGFGDFVNNDDSWRPIVENIEQRYDTYLEAENKVNRSNIVDNRIHACVYFIQPTGHSLKPLDIEVMRRLHTKVNLIPVIAKADTLTDEEVALFKQRILADIEQHSLQIFEGPRYELDDEETIAENQEIMSKVPFAVVGANSEVTTADGRRVRGRSYPWGIIEVDNEEHCDFVKLRQMLIRTHMEELKEHTNNFLYENYRSDKLTLMGVAQDPSVFKEVNPAVKQEEERALHEQKLAKMEAEMKMVFQQKVAEKESKLKQSEDELYARHREMKDQLDRQRGELEEKKGRLETGRPVEEKGKRKGFSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PSL9</accession>
    <name>A0A0G4PSL9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc finger, C2H2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S036g000028</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793169">
        <property type="protein sequence ID" value="CRL29444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PSL9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PSL9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL29444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="219" mass="25115" checksum="1D9FD7B7168D5C8A" modified="2015-09-16" version="1">MAYSSFNLPTDLPNVPEELDWRVVLSHPENNFIHRFHPSMTADTSMFSGNHLLYNGIAQHPSTPQHPDFVMPRAPTHLNLHEFDQHTINFPAEDTGIRNCSARDSTRHSPISTTILASPPTEDEPSQINTNTKRHPQGRVPSDCVQTYKPKKEEVHGSFNCYWKDCKYGRVFSGKGVLMRHIETQHVLPRSIDCPVCGRFFSRKDNMTEHLGRVHHKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PSV1</accession>
    <name>A0A0G4PSV1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S037g000041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793170">
        <property type="protein sequence ID" value="CRL29554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PSV1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL29554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="524" mass="58887" checksum="01BB434DEE2C99D3" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PTH8</accession>
    <name>A0A0G4PTH8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glucose-methanol-choline oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S039g000007</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793172">
        <property type="protein sequence ID" value="CRL29698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PTH8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PTH8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF119">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="9">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="518"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="570"/>
            <end position="571"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL29698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="666" mass="74116" checksum="D2851409B20085A5" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PTX5</accession>
    <name>A0A0G4PTX5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial GTPase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S040g000049</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Mitochondrial GTPase involved in assembly of the large ribosomal subunit. Plays a role in expression of the mitochondrial translational machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793173">
        <property type="protein sequence ID" value="CRL29823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PTX5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PTX5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01856">
        <property type="entry name" value="YlqF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000009">
        <property type="entry name" value="Mitochondrial GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001753">
        <property type="entry name" value="Mitochondrial GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016478">
        <property type="entry name" value="GTPase_MTG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782:SF4">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006230">
        <property type="entry name" value="MG442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="6">
        <location>
            <begin position="134"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="303"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="323"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="142"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006230-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL29823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="339" mass="37898" checksum="A63E1C9AB2FE86F0" modified="2015-09-16" version="1">MAQFVPRNAFPHYGAIPRSYFLGHHRAGLTKMKSMLSTIDYVVECRDYRAPVTSINPMFEEALGKMRRLVVYTKRDLGSIPKSSAQKITERKLQSFDPKSAVFFTSSSSRPDVSQIIKHLRTDAEAPDKLVGCRVLVVGMPNVGKSTLINNLRNSGTGKAKALKTGQQPGITRKIATQVKIIDRENGSHVYVLDTPGVFMPYVPEAENMLKLALCGCVKDNVISAITLADYLLYHINLNDPTVYKRWSEPTNDVVPLIESFARQTGLLAKGGVPMMDGAALLFIQKWRQGELGRFLVDDLEAEQQRREDPTQTPRMSMTQALRVERTTRKNKPDATSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PU16</accession>
    <name>A0A0G4PU16_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S038g000049</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793171">
        <property type="protein sequence ID" value="CRL29646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PU16"/>
    <dbReference type="STRING" id="1429867.A0A0G4PU16"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024789">
        <property type="entry name" value="APC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024790">
        <property type="entry name" value="APC4_long_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260">
        <property type="entry name" value="ANAPHASE PROMOTING COMPLEX SUBUNIT 4 APC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12896">
        <property type="entry name" value="ANAPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="7">
        <location>
            <begin position="25"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4 long" evidence="8">
        <location>
            <begin position="294"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="817"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="820"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL29646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="860" mass="95194" checksum="1B592361436E618D" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PU38</accession>
    <name>A0A0G4PU38_PENC3</name>
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        <submittedName>
            <fullName evidence="2">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PCAMFM013_S038g000091</name>
    </gene>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
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        <property type="protein sequence ID" value="CRL29688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PU38"/>
    <dbReference type="STRING" id="1429867.A0A0G4PU38"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053710">
        <property type="entry name" value="Arylamine_NAT_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786:SF0">
        <property type="entry name" value="ARYLAMINE N-ACETYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786">
        <property type="entry name" value="N-HYDROXYARYLAMINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL29688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="317" mass="35838" checksum="62C1874A57A8C60F" modified="2015-09-16" version="1">MAHTPTYTDQQLELYLNRIGYSHSAQSESNLLPHLRQDIENDALSALCHLQRRHLAAIPWGNSGLHYSQHHTISLNPHSLFEKMVERQLDGYCMENTGIFFIVLRSLGYLVYATGGRVSHAAAKGVDNGLYLAIGHMVLIVIIGGEKYMVDVGFGNNCATAPLLLQEGATATAIAPSEMRIVRESIAEFTDPSQKIWIYQTRYNPESKWLPQICFSEVEFLPQDFGVMNFSVSQSRTSWFTQVFVCMRMILDQTGTEIIGQCVMSGKEVKERLRGQTEILQVLETEEDRVKALAKYFDMHLRQSEIQGIRGMTSELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUN7</accession>
    <name>A0A0G4PUN7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S046g000049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793179">
        <property type="protein sequence ID" value="CRL30245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PUN7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="CRL30245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="226" mass="26125" checksum="B2D18B06EC879C54" modified="2015-09-16" version="1">MSHPGNNLFLFVRNLDQGTREHLEHNTNTGPAHLTPEPCSSIPTESQAPAIMPLVEDFYFPFPRTSFRAAETTLIVQKVWFLGSKYLKRAIKRQHKLNDRTTFLISSCQALRKYRYLPRGKRRALAKNRRLSNYAHRMTGELADCDLAMLSLLAWHFSSKMVPLPQGLLQFFANFDEQFDTVCRSIHPTYTKMCEPDTLANFKERLRGLLRLLERHVIIGDGVLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PV32</accession>
    <name>A0A0G4PV32_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S047g000016</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793180">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PV32"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL30288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="78" mass="8911" checksum="C588978C53C7B568" modified="2015-09-16" version="1">MPPPNTPQKTVKEHSSRPEVEFQEHSFQFTEKDGVLLPPMLKKLSSFFQPDSSILETPSTITFAISAHLLLIMRQKMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVF8</accession>
    <name>A0A0G4PVF8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger, MYND-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S045g000025</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793178">
        <property type="protein sequence ID" value="CRL30159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PVF8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027974">
        <property type="entry name" value="DUF4470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14737">
        <property type="entry name" value="DUF4470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="18"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL30159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="565" mass="65251" checksum="1F7BBB87D5F602EC" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVP2</accession>
    <name>A0A0G4PVP2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S050g000023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793183">
        <property type="protein sequence ID" value="CRL30376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="77" mass="9006" checksum="EC808BF81640FACB" modified="2015-09-16" version="1">MENNNISASGLLNLMLLIAVVFLWGFIVMYFVVVYKFSRTEYSSGSDPRVSIKWELSITRRPDPYMKTQHHCCRKDT</sequence>
</entry>
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    <accession>A0A0G4PW83</accession>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793188">
        <property type="protein sequence ID" value="CRL30602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PW83"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL30602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="68" mass="8013" checksum="4DDA2F185171C9DE" modified="2015-09-16" version="1">MQLWNGPRTYEGCKARDEMTRVTRRSGFRRLSYSKLGTLEKSIPPWNLLFTGFEFLRINTEDSQKKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PWB0</accession>
    <name>A0A0G4PWB0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S055g000042</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793188">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR38049">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38049:SF2">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195673" evidence="2">
        <location>
            <begin position="18"/>
            <end position="218"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL30627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="218" mass="24512" checksum="6BB1529CAAE32280" modified="2015-09-16" version="1">MVLGIVMMTAMVPTIMGLNEASKGTRDQENSRKNTARKQRCHLVAMCEVNKGTQTQREQVHNARVYVGRDGNLYITKQPSSTMSLFNGGFYTHPDFPPDNTSGVVTITGEQPPTLRWVFLDSNTHQMRWGGRPDSEGHICGPFDWTKDEQCITLEGWEGWLAVRLPEDHTREQAEADLEIGDGSEIWRLYFDQNDDGADLPPGSEGIEIRLKRATSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PWQ0</accession>
    <name>A0A0G4PWQ0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793188">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PWQ0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="VC0802-like"/>
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    </dbReference>
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        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR051719">
        <property type="entry name" value="CASTOR_mTORC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31131:SF6">
        <property type="entry name" value="CASTOR ACT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31131">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CASTOR ACT" evidence="2">
        <location>
            <begin position="119"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL30615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="485" mass="52889" checksum="1DF799089C8C93B3" modified="2015-09-16" version="1">MDQSMTLIDAQVQFLEECVVLVHIPLELYPYFLKSVLRLIFDEIPPLEDEKDDDAAFDDFEDASEHDSAYKAPAFMNVSITPVEVSVMCPRRLVNKYFIPVMDQLDQLDDSLRSRLIVSENDYIAMQVLGEGLEAGKRVLELTSPLALAGISIFFISTYFSDYIVVPKQSKASVISALEKRGFQFNNASAAFITNPLSPTIERRLSDLIPPGTPPPSTLGELQSRTFNNLRKHQITPSVDDSLRLVQCAAHHEYHTQESSMSILRDALTTVLLVDEPRFLSLTLAALDPAASLLLEKRLLPRFARQSVSSRGTPLYEDGSGLLLGSKEDHLIPITLDLRDLPLEASGIVCGVAGRLAAAATVPLSSHTGSINSGVSSVLGSVPGLFDSFGARLAALSIDKSSTSAPSHGLQPLPHSTHHLQPDVDVADAVEISFLSTARAGTIIVGEDELRRAIDALEEEKMQSPRLDGIVFESQTPPDSPQHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PWX4</accession>
    <name>A0A0G4PWX4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S056g000036</name>
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    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793189">
        <property type="protein sequence ID" value="CRL30663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PWX4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL30663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="109" mass="12415" checksum="A0096201FE30096A" modified="2015-09-16" version="1">MGTKIPRDWTNDPEELRVNDWNAGGDFEEVVDTNVLGKVRPIMCSGRNSDDFLYMFEAGGTFYVWDQIEDTIWRICQPNTETKIIEVIGERGLKGLGLDALAEVEEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PWX7</accession>
    <name>A0A0G4PWX7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">N-terminal acetyltransferase A, auxiliary subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S057g000027</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CYC8/SSN6 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793190">
        <property type="protein sequence ID" value="CRL30705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PWX7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PWX7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000078">
        <property type="entry name" value="Transcriptional corepressor Cyc8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000163">
        <property type="entry name" value="Transcriptional corepressor Cyc8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000282">
        <property type="entry name" value="Transcriptional corepressor Cyc8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051630">
        <property type="entry name" value="Corepressor-Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017:SF1">
        <property type="entry name" value="LD02225P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4 9" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="56"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="160"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="197"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="234"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="306"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="340"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="421"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="575"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="451"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="488"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="631"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="677"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="709"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="736"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL30705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="806" mass="88843" checksum="A6FE70014A30AC8F" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PX63</accession>
    <name>A0A0G4PX63_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">1,4-alpha-glucan branching enzyme, core region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S065g000015</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793198">
        <property type="protein sequence ID" value="CRL30965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PX63"/>
    <dbReference type="STRING" id="1429867.A0A0G4PX63"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033934">
        <property type="term" value="F:glucan 1,4-alpha-maltotriohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000025">
        <property type="term" value="P:maltose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11333">
        <property type="entry name" value="AmyAc_SI_OligoGlu_DGase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000064">
        <property type="entry name" value="Oligo-1,6-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000004">
        <property type="entry name" value="Oligo-1,6-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF232">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 13 CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="5">
        <location>
            <begin position="50"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL30965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="650" mass="74486" checksum="CA1732EC6919CB5F" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PXI1</accession>
    <name>A0A0G4PXI1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alcohol dehydrogenase superfamily, zinc-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S092g000004</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793223">
        <property type="protein sequence ID" value="CRL31229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PXI1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PXI1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000721">
        <property type="term" value="F:(R,R)-butanediol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034079">
        <property type="term" value="P:butanediol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF23">
        <property type="entry name" value="(R,R)-BUTANEDIOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
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</entry>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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            </authorList>
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        </citation>
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        </source>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CRL31270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="62" mass="7355" checksum="A760C4E3F59607C2" modified="2015-09-16" version="1">MGLRRHQPTYYSLTKKGTYCKLYPTVNNINKGRNKLKALTRRQFNPSALPILRDITSHFLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PXX0</accession>
    <name>A0A0G4PXX0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S068g000007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
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                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PXX0"/>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL31021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="147" mass="16271" checksum="C5EED3D84E5D717A" modified="2015-09-16" version="1">MAYNLSIEVFGPGDSPTHRSHWGFMINKPGNLEFGDLLQVEIIDASRLWYGFAPRYATKIVDKAAVGMCKIADLTSQQRHDAIKVIEKEPAPKNSIGRCQDWIFDALLALEIEELVPSGTSAFWKGMIGRPAREVAAACGTQWTAFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NT36</accession>
    <name>A0A0G4NT36_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S001g000089</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4NT36"/>
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    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF25">
        <property type="entry name" value="ABC-TRANSPORTER-REGULATING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="631"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="59"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="161"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="707"/>
            <end position="782"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
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            <end position="193"/>
        </location>
    </feature>
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            <begin position="457"/>
            <end position="472"/>
        </location>
    </feature>
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        <location>
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            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="746"/>
            <end position="758"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL17129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="870" mass="96632" checksum="16B9B4F583159B92" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NT38</accession>
    <name>A0A0G4NT38_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD40/YVTN repeat-like-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S001g000235</name>
    </gene>
    <organism evidence="3 4">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
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                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
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    <dbReference type="STRING" id="1429867.A0A0G4NT38"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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    </dbReference>
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        <property type="entry name" value="DUF7165"/>
    </dbReference>
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        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23749">
        <property type="entry name" value="DUF7165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
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            <end position="528"/>
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        <location>
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            <end position="20"/>
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        <location>
            <begin position="827"/>
            <end position="847"/>
        </location>
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        <location>
            <begin position="688"/>
            <end position="708"/>
        </location>
    </feature>
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        <location>
            <begin position="744"/>
            <end position="759"/>
        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL17275.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="875" mass="97310" checksum="EE53AB336D8489D8" modified="2015-09-16" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">FM 013</strain>
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        <subcellularLocation>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="543"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="634"/>
            <end position="654"/>
        </location>
    </feature>
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        <location>
            <begin position="161"/>
            <end position="658"/>
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            <end position="102"/>
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            <end position="428"/>
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    </feature>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL17363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="670" mass="74306" checksum="D4A5F1D2B3FBACCF" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NTL4</accession>
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        <submittedName>
            <fullName evidence="20">Ribonuclease III</fullName>
        </submittedName>
    </protein>
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        <name evidence="20" type="ORF">PCAMFM013_S001g000361</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
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        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
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        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the helicase family. Dicer subfamily.</text>
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        <property type="protein sequence ID" value="CRL17401.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="entry name" value="Dicer-like protein 1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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    </dbReference>
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        <property type="match status" value="2"/>
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    </dbReference>
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        <property type="entry name" value="Dicer_dimer_sf"/>
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        <property type="entry name" value="Dicer_dimerisation"/>
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        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF37">
        <property type="entry name" value="ENDORIBONUCLEASE DICER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51327">
        <property type="entry name" value="DICER_DSRBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3" id="KW-0930">Antiviral protein</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="11 15" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="19"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="352"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Dicer dsRNA-binding fold" evidence="19">
        <location>
            <begin position="548"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="16">
        <location>
            <begin position="909"/>
            <end position="1039"/>
        </location>
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</entry>
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        <location>
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            <end position="1008"/>
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            <end position="269"/>
        </location>
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            <end position="346"/>
        </location>
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        <location>
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            <end position="756"/>
        </location>
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            <begin position="1121"/>
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            <begin position="1194"/>
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        </location>
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            <begin position="233"/>
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            <begin position="330"/>
            <end position="339"/>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NY27</accession>
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        <submittedName>
            <fullName evidence="7">Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase</fullName>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
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            <name>thiamine diphosphate</name>
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    <comment type="similarity">
        <text evidence="2">Belongs to the XFP family.</text>
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    </dbReference>
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        <location>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
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    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL18988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="810" mass="91258" checksum="763AB82EF1BCD756" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYL7</accession>
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        <submittedName>
            <fullName evidence="5">Nucleotide-binding, alpha-beta plait</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="ORF">PCAMFM013_S002g001033</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
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    <dbReference type="STRING" id="1429867.A0A0G4NYL7"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21245">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="82"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="196"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL19163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="287" mass="32045" checksum="14BFF378AAE44FC6" modified="2015-09-16" version="1">MNDTESPRLEEQQTPTKSPFANVRTDGRAFNSPNWRMKVESPATPSRTNASPSASPNPNPNTSRAAFSRPGAHVPQAINDGRRLYVGNMPYTAKMEDVEALFIAAEFPIERIDIAIDPFTGRNPSYCFVDLQNKEHAERAMTELDGRDMLGRPVKIKPGVAKSQERTQNPSDPFRVDRWRQQERPSFAKVNSDSSSRVYVGGLPRLTDHGAVQSNMELFFKGFKVENVSKVFAPHPAKRFDPGEHYYLFVDVGTPEQALKAMDTLNGQEGPWGGPLRVQFARGPKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYY3</accession>
    <name>A0A0G4NYY3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Smr protein/MutS2 C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S003g000078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NYY3"/>
    <dbReference type="STRING" id="1429867.A0A0G4NYY3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053020">
        <property type="entry name" value="Smr_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47417">
        <property type="entry name" value="SMR DOMAIN-CONTAINING PROTEIN YPL199C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47417:SF1">
        <property type="entry name" value="SMR DOMAIN-CONTAINING PROTEIN YPL199C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="2">
        <location>
            <begin position="98"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL19287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="243" mass="27133" checksum="7EB0C9B3918B5B73" modified="2015-09-16" version="1">MSHEMSHMGPRAFNHDNSTDAEAEYDRLRDLARQEASKRGQCFSRSKEAYSSGDGAGAKQLSEEGKAHGRKMEEYNRQASEFIFRENNASGRVEADTIDLHGQFVEEAEEILEERIKYAKSHGQNHLHVIVGKGNHSANHIQKIKPRVEQVCRELGLQYATEDNAGRIYVNLTGGEAVMPPSSGHQGGSSGYPGHQQGHQQGHQQQQHGQQQGQQQPDELEELAKKILPKVLRKLEKACCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZ21</accession>
    <name>A0A0G4NZ21_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S003g000099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZ21"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL19308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="84" mass="8993" checksum="CEE8FD552FC1726C" modified="2015-09-16" version="1">MAFTGPIMESCIIEYAQGTWALRSEFQQLLSSGPANAQSKCSQGVRNTAGMTRGILEKTRYSDVHDHTGSVGFGATPEATLTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZ33</accession>
    <name>A0A0G4NZ33_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MICOS complex subunit MIC10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S003g000085</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Mitochondrion inner membrane</location>
            <topology evidence="2 9">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the MICOS complex subunit Mic10 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZ33"/>
    <dbReference type="STRING" id="1429867.A0A0G4NZ33"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007512">
        <property type="entry name" value="Mic10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21304">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21304:SF0">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04418">
        <property type="entry name" value="DUF543"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL19294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="91" mass="9963" checksum="34311AC3E93F86D5" modified="2015-09-16" version="1">MAESSESGPIARATKPVSEALLNEKWDRAISSVLIKSSLGLSFGVVFSVLLFKRRAWPAWVGLGFGAGRAWEEADASFRRGDSPIRDALRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZ94</accession>
    <name>A0A0G4NZ94_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Cysteine proteinase 1, mitochondrial</fullName>
            <ecNumber evidence="2 9">3.4.22.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S003g000182</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity.</text>
    </comment>
    <comment type="function">
        <text evidence="7">The normal physiological role of the enzyme is unknown, but it is not essential for the viability of yeast cells. Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity. Acts as a repressor in the GAL4 regulatory system, but this does not require either the peptidase or nucleic acid-binding activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred.</text>
            <dbReference type="EC" id="3.4.22.40"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. Binds to nucleic acids. Binds single-stranded DNA and RNA with higher affinity than double-stranded DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.40" evidence="2 9"/>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZ94"/>
    <dbReference type="STRING" id="1429867.A0A0G4NZ94"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070005">
        <property type="term" value="F:cysteine-type aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043418">
        <property type="term" value="P:homocysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00585">
        <property type="entry name" value="Peptidase_C1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004134">
        <property type="entry name" value="Peptidase_C1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363:SF2">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03051">
        <property type="entry name" value="Peptidase_C1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005700">
        <property type="entry name" value="PepC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0788">Thiol protease</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005700-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL19391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="497" mass="56002" checksum="7B656B5BDDA7D7C9" modified="2015-09-16" version="1">MGSAVSKPVPLNEKASSAEREEARADVTEQASWESSLPPYPAQERVIPLTLTRINDWNQTLLSDPKNRLAISSFADHSFEDILVNHNALQLDQHIFNLTVPVEGTPITNQRSSGRCWIFAATNIFRLPLIKAYQLKDFELSQAYLFYWDKIEKANWFFEQIIATAHEDLSSRLVQKLCQDPVSDGGQWDMVVNLVQKYGLVPHTLYPDGYHAQNSAKMNWLLTTKLRDQAFVLRELAAKSPHSLPAAKEQFLQEIHSLVTLLLGPPPSPDKKFVWQFSDANGTARDVQLTPLEFAQQAFRPRSISRGHPTVSTGRLFSLVNDPRHEFNRLLTIERLGNVVEGRPITYVNVEIDTIKNAIIAMLRAGYPVFFGCDVGKFYDRDRGVLDTDLTDLALGFNITLSMTKAQRVASGASSMTHAMVITGVHLDGDRPVRWRVENSWGEAAGKGGWFVMTDRWMDEYTFQAVVDFNFVSADVQAILEQSPKVLPRWDPMGVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P064</accession>
    <name>A0A0G4P064_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S003g000479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P064"/>
    <dbReference type="STRING" id="1429867.A0A0G4P064"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="76"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL19688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="542" mass="61852" checksum="66530B797F21E4B1" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P082</accession>
    <name>A0A0G4P082_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S003g000513</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P082"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012:SF6">
        <property type="entry name" value="BZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL19722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="425" mass="48878" checksum="475CABA615666631" modified="2015-09-16" version="1">MGRYSFFRCGLWARMGDRSPSERIASLLGIVLLATVFAALIGLFMSHLTSADPVVPRHEGTKIMSSNEKKRLRDRRSQQTLREKKLRHISQLEEQVAHCEQHHSDQGVQRLLQVIEGLRKQNEALLKRQKSLKSLVDSWETELEEPAATDDSSHDLSSLYKEMSNREAQFSLQTNFNDSIPPHGISSLLNAPISAASTPRQKRSPSLEPLSAVTTPLWNQIPPHTDDFGTRTMISCPWFLYPELIIPCPDVPNSPLDFIYGTKTNALADQIHTALQRRPVRDPERLGTGWLTYHFSRWVIAPSPETYGRLPAFLRPVQGQMTVPHPLVLDFMPWPRLRLNLIRRWHVYGKDRDGLFGFMACCVKLRWPWNETVLERNEHNELCMKKAFYETIMSESGWGLTPEFIRRYPDLVEGMDINKIVVELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0A1</accession>
    <name>A0A0G4P0A1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S003g000533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P0A1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL19742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="222" mass="25931" checksum="2D4A3DC0D2EBF001" modified="2015-09-16" version="1">MRRYSPWEENGRTLRRWIERSDQPRCPYPLSTFAVTHDPQPQEYSVTHGAVWLDSTWDTWIYPLDQPVELNNIEIENRQGPPVGWEGRTGRGVVFLDWIRRSKRSTAPHISEFTKAAYEMDFPLESLKYVFVTDISETDTVQCIRDEVCKSEGIPYLFSEQGIWDSRSREFDALLGTRMGKTVAAFISCAWGQGIKRVARIVTFHDGEYLQRLNMRFDIEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0B3</accession>
    <name>A0A0G4P0B3_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amine oxidase</fullName>
            <ecNumber evidence="6">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S003g000519</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a secondary aliphatic amine + O2 + H2O = a primary amine + an aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:26414"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:58855"/>
            <dbReference type="ChEBI" id="CHEBI:65296"/>
            <dbReference type="EC" id="1.4.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="6"/>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P0B3"/>
    <dbReference type="STRING" id="1429867.A0A0G4P0B3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097621">
        <property type="term" value="F:monoamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050703">
        <property type="entry name" value="Flavin_MAO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563:SF14">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="8">
        <location>
            <begin position="597"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="275"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="333"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="362"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="413"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="432"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="466"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="519"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="550"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="598"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="617"/>
            <end position="618"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="827"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="932"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="1015"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601613-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL19728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1042" mass="113854" checksum="9E6B0C86A96597DD" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0C2</accession>
    <name>A0A0G4P0C2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S003g000515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P0C2"/>
    <dbReference type="STRING" id="1429867.A0A0G4P0C2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL19724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="399" mass="45059" checksum="C3FF48F5F636C0A9" modified="2015-09-16" version="1">MAASNSTALVSWQLEDNSRSTFALVWSCLSTIFVCTWTVLHPSLPRRNSPAVRRIISNFAYWLLAVFFPEYVFVNASQMRYRAMLLKNGCDEAQKTRYLESVDPEAWLSKRARPLDQVQNQDSTDPHPFQTEWTLRKCFCIIAGGLALQTQDGWIYVLRRGDMKPFIEAGIVEDIDFHDREVEDHAKADSLGKIFTVLQTSWFLFNIIARWATSLPVAPIELATVAYIPCAILMYAMWWYNPKDMTTPITIYVRCDRTNLPTHLLNLTATNPHGWVHRHAQVKKQTVLSVFAQAAQWFVDAATGPADTSYEVAYDGFYKPSHGCIVAGINTFVAFLYCGIHLVGWNFPFPTGAERITWLVSSLACVVLVGIYSLASTIPIALPVGSYTTVEWVMSIPHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0J7</accession>
    <name>A0A0G4P0J7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">N2227-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S003g000623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P0J7"/>
    <dbReference type="STRING" id="1429867.A0A0G4P0J7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012901">
        <property type="entry name" value="CARME"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303:SF13">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07942">
        <property type="entry name" value="CARME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01296">
        <property type="entry name" value="N2227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL19831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="424" mass="49055" checksum="9F2EE57F8092E792" modified="2015-09-16" version="1">MLREAFFIFICVAWAGFAIHLSPWIKDISYKVQPYNTTSQYSVPLSTHNEEHTRLLQKLERSSGKWDTTHPRHRLLTALHGYTRYKDKNLAEVDRLRNLYKNVPKRQRTMLESTVHYTRKLNTMEHLLDTNNELARSIVDHGLWFYNITQSELDEFIKENESQQRSADKTSVSQGMKHFVRDWADEGREEREQSFGCILKSISHTPRTKDRPLRVLLPGAGLGRLAHEVDKLGGFEVTMNEWSMYMNLAYRYVSSLSVPNSVPFHPYIDWWSHQPTTNDLQRSVTFPNEVIHPSSVLLIEGDFTTVFAEHTGQYDILVTLFFIDTARNLVTYLETIHRLLRPGGRWVNLGPLLYGTAPFVQLSLDELVTLSESMGFDFQETDSTIGNITLPNLPVRGLEVAYGRNGRGLNKNAYQAQYWEAVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P1G2</accession>
    <name>A0A0G4P1G2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EGF-like, type 3</fullName>
        </submittedName>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4P248"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="496"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="532"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="574"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="610"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="643"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="742"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1152"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1185"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1229"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1267"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1299"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1420"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="134"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="826"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="787"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="787"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL20384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1466" mass="162808" checksum="47B5953D317341B1" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P4B6</accession>
    <name>A0A0G4P4B6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Complex 1 LYR protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S005g000345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4P4B6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090324">
        <property type="term" value="P:negative regulation of oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Complex1_LYR_ETFRF1_LYRM5"/>
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        <property type="entry name" value="ETFRF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21024:SF0">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN REGULATORY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GROWTH HORMONE-INDUCIBLE SOLUBLE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL21181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="85" mass="10361" checksum="9BD90E055D08E957" modified="2015-09-16" version="1">MVNLELRRQVINVYKELLFLGREYPLGYQYFRDRLHRAFASQTHITDDEQIRKGIARAEFVKKEVEALYYLKRYRTLKKRYGSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P639</accession>
    <name>A0A0G4P639_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC multidrug transporter MDR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S006g000308</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000057">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000913">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <end position="69"/>
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    <sequence length="1346" mass="146157" checksum="6BEA6EB4B0B0D809" modified="2015-09-16" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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                <person name="Abraham A.L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="305" mass="32606" checksum="266AA7C8B8F11F68" modified="2015-09-16" version="1">MSSSTIKSVLVIGPGGNVGRSTIKALLDEKFEVTGLTRQSSEAILPPGVKHIKSDYSEASLRDAFKGQDAVISTISSIVPGDALTLQKSLVDSAISAGVKVFFPSEFGIDTSDRSASEYIPFLVDKIQTVDYLKAQQDKISWTAVITGSLFDWGLNIPGFGGLNVPAHTATVFDGGDISYEATSLDQVGRAIARSLKNPDLTKNQYVYVNSFTVTQNKVLSALERATNEKFTLSKDTVENLWQDGATKVKEGQLLGTLSMIAGSILGKGGLANYSKTKGLWNEILGLPQEDLDGFVREYLAGGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7Y7</accession>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S007g000422</name>
    </gene>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
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        <property type="protein sequence ID" value="CRL22441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P7Y7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037459">
        <property type="entry name" value="RhgT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695:SF1">
        <property type="entry name" value="RHAMNOGALACTURONAN ACETYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195462" evidence="3">
        <location>
            <begin position="17"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL22441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="250" mass="25826" checksum="BEB810FA9A2643ED" modified="2015-09-16" version="1">MKSAILLSALIPSALGTTIFLAGDSTMATGGTGSNTAGWGEYVTPYTSLGVSNQAVAGRSARSYTREGRFDAIEAVVQSGDWVIIEFGHNDGGSLTPTDNGRSDCSGTGSETCSTTYNGVAETVLTFPAYIENAAKAFKDKGANVIISSQTPNNPWETGTFTYTPSRFVGYAESAAAAAGVSYVDHGAYVADQFQTLGLTAVDAYFPLDHTHTSPTGASVVAQAFFKAVVCGDVALKDSLSTTSFPGSCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P841</accession>
    <name>A0A0G4P841_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exocyst complex component EXO84</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Exocyst complex component exo84</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S007g000477</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Plays a role in both the assembly of the exocyst and the polarization of this complex to specific sites of the plasma membrane for exocytosis. Also involved in assembly of the spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the exocyst complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EXO84 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P841"/>
    <dbReference type="STRING" id="1429867.A0A0G4P841"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000264">
        <property type="entry name" value="Potential exocyst complex component Exo84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1220">
        <property type="entry name" value="Exo84p, C-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1210">
        <property type="entry name" value="Exo84p, N-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033961">
        <property type="entry name" value="Exo84"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032403">
        <property type="entry name" value="Exo84_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042561">
        <property type="entry name" value="Exo84_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042560">
        <property type="entry name" value="Exo84_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426:SF12">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16528">
        <property type="entry name" value="Exo84_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25345">
        <property type="entry name" value="PH_EXO84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst component Exo84 C-terminal" evidence="14">
        <location>
            <begin position="447"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="136"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CRL22496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="683" mass="75986" checksum="6D063A40529086FF" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P845</accession>
    <name>A0A0G4P845_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Pyrimidine-specific carbamoyl phosphate synthase-aspartate carbamoyl transferase</fullName>
            <ecNumber evidence="6">2.1.3.2</ecNumber>
            <ecNumber evidence="5">3.5.1.2</ecNumber>
            <ecNumber evidence="19">6.3.4.16</ecNumber>
            <ecNumber evidence="4">6.3.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">PCAMFM013_S007g000482</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="24">Multifunctional protein that encodes the first 2 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase; EC 6.3.5.5) and aspartate transcarbamylase (ATCase; EC 2.1.3.2). The CPSase-function is accomplished in 2 steps, by a glutamine-dependent amidotransferase activity (GATase) that binds and cleaves glutamine to produce ammonia, followed by an ammonium-dependent carbamoyl phosphate synthetase, which reacts with the ammonia, hydrogencarbonate and ATP to form carbamoyl phosphate. The endogenously produced carbamoyl phosphate is sequestered and channeled to the ATCase active site. ATCase then catalyzes the formation of carbamoyl-L-aspartate from L-aspartate and carbamoyl phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="18">In the 2nd section; belongs to the CarB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the 3rd section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the C-terminal section; belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">In the N-terminal section; belongs to the CarA family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="6"/>
    <dbReference type="EC" id="3.5.1.2" evidence="5"/>
    <dbReference type="EC" id="6.3.4.16" evidence="19"/>
    <dbReference type="EC" id="6.3.5.5" evidence="4"/>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4P845"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005951">
        <property type="term" value="C:carbamoyl-phosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 26" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10 26" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-grasp" evidence="27">
        <location>
            <begin position="596"/>
            <end position="788"/>
        </location>
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        <location>
            <begin position="1131"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004812"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013008"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00043968"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00043979"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00043984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00043998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00058513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00081752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="CRL22501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="2247" mass="246750" checksum="557238F9FCCD0F54" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P8G7</accession>
    <name>A0A0G4P8G7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S007g000540</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
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        </citation>
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        </source>
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        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE-RELATED"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="155"/>
        </location>
    </feature>
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        <location>
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            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="253"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
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        </location>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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        <location>
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        <location>
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            <end position="499"/>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
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                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
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                <person name="Debuchy R."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793141">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PHOSPHORIC MONOESTER HYDROLASE"/>
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    </dbReference>
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        <property type="entry name" value="UPF0655 PROTEIN YCR015C"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL22830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="335" mass="37920" checksum="725C83D8500FF599" modified="2015-09-16" version="1">MAISQTNTDHQKRKIIIFSDFDGTIFLQDTGHVLVDNLGCGAAYRNKLEEQFKTGERSFRDISDDMWGSLTIPFGDGFDIMEKNLEMDPGFQEFHQYCVREGFPFNVISAGLKPVLQRTLDLFLGEKEASSIQIVANDLKAPGGIPWKPVWRDNTESGHDKGESVNQARTKAQAECEPDEIPLIVFIGDGVSDLAAAREADVLFARRGLRLEEYCLEHGIPYTPFDSFADVKREVEAISLEDQKKTGGVGKPVRYNPRANMWRRISSKEAVCFPHFPFVLNEKEREKKRHSLMVVVLQVPTLMATATPSQDEKMALWPDYFSEPKQTQTEPTIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P9L7</accession>
    <name>A0A0G4P9L7_PENC3</name>
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        <submittedName>
            <fullName evidence="7">Transcription factor, MADS-box</fullName>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL23007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P9L7"/>
    <dbReference type="STRING" id="1429867.A0A0G4P9L7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="6">
        <location>
            <begin position="34"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL23007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="121" mass="13999" checksum="3448898833CAE1D5" modified="2015-09-16" version="1">MEPSPVVNISLPTNIANSKFKTSHARRGNQKSLRRRETLLKKIFEYCTECDADIHFVLRMKKTGQLYTLTSNAKEWPLSTEQINKESNHPEPIQMKMDELAIKYQGQSPQGEHRPMSLLKD</sequence>
</entry>
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    <accession>A0A0G4P9T2</accession>
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        <submittedName>
            <fullName evidence="7">Transcription factor, fungi</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">PCAMFM013_S009g000016</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793142">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4P9T2"/>
    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="248"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="78"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="695"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL23076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="750" mass="83308" checksum="251F695A1D7401BA" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAF0</accession>
    <name>A0A0G4PAF0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="4">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S009g000215</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="4"/>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PAF0"/>
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    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="28"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL23275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="496" mass="52757" checksum="89E70776A212D0C8" modified="2015-09-16" version="1">MSSKLTVTGIQGRQVTIPTGLFIHNEFVPSSTGQTLAVENPSTGDQLGTISAAGPEDINKAVESAKSAFKTWRTVPGPVKAQLLLKLADLLERDAQDLASLEAVDAGVLYTDSIGMNIPQAVGCLRYYAGWAGKIDGKTLDIDGGIAYTHREPLGVCGAIVPWNAPLMITIWKLAPALVTGNVLIIKSSELSPLYAQKLAELVKEAGIPPGVVNIVTGEGASAGQALSEHMDVRKIAFTGSDLSGRKILQAASRTNLKKVSLELGGKGPSIVFDDCDIENALLWTRIGITANNGQICAAGSRIYVQASIYDRFIEAYKKAAADAPTVAGNPLDASTTKGPVVSRVQHEKILDFIHQGKQSGAKLLFGGERIGDKGYFVENTAFADVGDDATIMREEIFGPVASIAKFTTEEEVIFKANDSHHGLSAAIFTNDVNRAHRVVKELESGQVTVNAWAMLSPNVPFGGVKQSGFGRDMGEDALEGWTTVKAVKYNILPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PB24</accession>
    <name>A0A0G4PB24_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S009g000409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
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                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
    <sequence length="196" mass="21416" checksum="8CDFC7941C9A90A6" modified="2015-09-16" version="1">MASKLQDHIDALHTLPLAEAIQAIADLTPGLTSVVPREYGYFVQHPDYDGIGNLNNIGSLWLKLGSKCYDDHAPLEVRLVHTSMDDPIYEVYGTSYVMLNKGLADGTVAPPAPDENPGYCACCSGEPDAIILACFHERQALYFTRGEYRALWGDAPNSGQKFGNGTGWVKRYINASKEQLEEALARNPSVGIPSML</sequence>
</entry>
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    </organism>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
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                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="entry name" value="DUF6546"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
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        <location>
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            <end position="501"/>
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        <location>
            <begin position="3"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6546" evidence="3">
        <location>
            <begin position="406"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20183"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL23743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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        </source>
    </evidence>
    <sequence length="501" mass="58222" checksum="1F38D8312243B506" modified="2015-09-16" version="1">MAASLPLELLLEIAALLRTDGVSLIPCTHVCRYWQAALEPLVYTNLAVYSDSYHKEKGRRGISLTHFQKLTSGSRSIRRNWIRRLEYDIIVPCKLLDWITSKTPDYRIDNQLRQANDFAFQTAIFDLFQTLHSWNQRCRLSLHLGLRESRHNRWPKAEPDAAHCPTASAYRSFDRYTGTRNMPIPPYRACFINKMSELYLVHVPCIDTLNVTNRSHDKNQLHQIWTGAIRTIIEHCPTLTELELDLNEWVRPDYLQYIQGRRASLGSLLGSIPSSLRVFRYKGAEDGPWKHTMPALNVIPSGIDSTTINLRNLSNHLRELKLNRTTLPFDFLCPLDWEGQPIIGSLHWPYLKTVEIEDVPPWLPSGKWTSTHTPAHRARIENGKWNDRMHDPERRWGGGPGGSVIDKEQFQRLLISVGYATQRMPSLKRMEFHMECYCRFYLYLQNDVSASMLQWQSHVQYQPDTRVAKAWKFDLNDVRVHSTPFGRCSVILPRWPPDKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PC50</accession>
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        <submittedName>
            <fullName evidence="3">Histone deacetylase superfamily</fullName>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793143">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Histone deacetylase HOS3"/>
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        <property type="entry name" value="HDAC_HD_type_1"/>
    </dbReference>
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        <property type="entry name" value="HDACs"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <end position="647"/>
        </location>
    </feature>
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        <location>
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            <end position="171"/>
        </location>
    </feature>
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            <begin position="750"/>
            <end position="938"/>
        </location>
    </feature>
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            <end position="113"/>
        </location>
    </feature>
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            <end position="144"/>
        </location>
    </feature>
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            <end position="819"/>
        </location>
    </feature>
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            <end position="911"/>
        </location>
    </feature>
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            <begin position="915"/>
            <end position="925"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL23887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="938" mass="101455" checksum="F4B65780A35E3897" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDA4</accession>
    <name>A0A0G4PDA4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Vacuolar protein sorting-associated protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PCAMFM013_S011g000304</name>
    </gene>
    <organism evidence="17 18">
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="2 12">Peripheral membrane protein</topology>
            <orientation evidence="2 12">Cytoplasmic side</orientation>
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    </comment>
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        <text evidence="3 12">Belongs to the VPS27 family.</text>
    </comment>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Vacuolar protein sorting-associated protein 27"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
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        <property type="entry name" value="HGS/VPS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049425">
        <property type="entry name" value="Vps27_GAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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            <begin position="516"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS50178"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL24310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="703" mass="76627" checksum="B1CD49D97645AE29" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDD6</accession>
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        <submittedName>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
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                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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            <begin position="6"/>
            <end position="29"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL24321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="49" mass="5360" checksum="5CDC3659647BF2D0" modified="2015-09-16" version="1">MVQRNITIAIIIIVLFLLLALAGFAIWAVNNHVSFFSKKKEADAESADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
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    <name>A0A0G4PDK9_PENC3</name>
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        <submittedName>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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                <person name="Giraud T."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <text evidence="2">Belongs to the major facilitator superfamily.</text>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="58"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL24413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="510" mass="56706" checksum="A16BBF3969D7268F" modified="2015-09-16" version="1">MADDISRENRDRIEIDAEKERIENVEHIASPQQDATPQMDPARRIVVEKKLKRKLDARCSLFVAIYIMNYLDRNNMAAARLKGLQEDLNLTNTEYSTCLSILYVGYIIMQVPSNMFINRISRPSLYIAVAMLLWGVISTLSGNTKNFGDMVAVRFLLGFVEAAFLPGALLILSKWYTRRELTTRNAILFCGNLISNAFSALVGAGVLSNMQGVMGHAAWRWLFWIEGSVTMFLAILAAFILPDLPHNARGFTEEERQVAQLRMIEDVGEADTDGEELGAFGGLLMALKDMKIYVMMLTFTAYVVGLSFNAFFPTLTGTLGFGYVPTLLMSAPPWVFSCIVSVINAWHADKTQEKVWHILGPIAMGAVGFVICMATNNVAARYVALFLQAGSYAGFIVFYSWISSSFPRPPAKRAVAIAMINAFSQLGNVAGSYVWDLEDNGYRSSYGIVLAMFGVTVGGCWYFRSMLVGLNHQLEEGELADVARGEPTESDIIDSPDESLRMRKGFRYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDP2</accession>
    <name>A0A0G4PDP2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S012g000059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
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</entry>
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        <name evidence="7" type="ORF">PCAMFM013_S013g000293</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL25050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PFJ9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PFJ9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL25050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="378" mass="42953" checksum="98E2682F39FFC631" modified="2015-09-16" version="1">MGPRRAHTKSRNGCQWCKARKVKCDETRPHCNNCFKHGIQCVFGESAPAGPARHSGSPPTLGTSSAPSPVSLGENTQTMGMAEMALLHHFSTSTCYTVSRNPILQTIWQIRIPQVSFSSPFVFRAIIALSALHLAHVKPEFHDHYVSQAELHHNTALQMVSAILPDVNQENCQSIYVFSILTCIISCAKPRIKQDFWANRDRDIEWLNLFRGTIHILASADRSLKTGPLAPMFEMGHRRKLARDARSATATPPFLLVLKQLLQDTVHDPSELQCYHDSIDDMAMSFATVSEIGSHNCETSDIFIWLLRVSDQYFGYFQQRAPEAMVIFAYFCVLMKEMEWAWWMQGLSVHTISGIYYILGEEHRCWLQWPMQQVGWVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PFK6</accession>
    <name>A0A0G4PFK6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S013g000335</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UTP23/FCF1 family. FCF1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL25092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PFK6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PFK6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09864">
        <property type="entry name" value="PIN_Fcf1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000019">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037503">
        <property type="entry name" value="Fcf1_PIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="7">
        <location>
            <begin position="65"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL25092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="193" mass="22109" checksum="C5B6174CCD853297" modified="2015-09-16" version="1">MGVQKKTRKYALAKRAISMRDNRLKQNQDKTEKGKEAKKDDLVKEAPQAPSSMFFQFNTALAPPYSVLVDTNFISHTIQHKLEVIPTMLDCLYAKCIPIVTDCVLAELEKLGPKYRLALRVAKDPRFERVKCDHKGTYADDCLVDRVIKHRVYIIATNDRDLKRRIRKIPGAPIMSVARGKYVIERLPDAPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PFS1</accession>
    <name>A0A0G4PFS1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid/polyamine transporter I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S014g000043</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PFS1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PFS1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF18">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="493"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="55"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL25147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="552" mass="61064" checksum="C439788E17167E7C" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PFT6</accession>
    <name>A0A0G4PFT6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S014g000079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PFT6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL25183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="50" mass="5257" checksum="11E375D5A4B05B88" modified="2015-09-16" version="1">MIPVVNHGRRTGNPEPGLLRHVRSIISVHGEQGAQSPGLLISPVNHLAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-11-27" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PFV5</accession>
    <name>A0A0G4PFV5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tubulin-specific chaperone A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S014g000099</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the TBCA family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PFV5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PFV5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.90:FF:000016">
        <property type="entry name" value="Tubulin-specific chaperone A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004226">
        <property type="entry name" value="TBCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036126">
        <property type="entry name" value="TBCA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21500">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21500:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02970">
        <property type="entry name" value="TBCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46988">
        <property type="entry name" value="Tubulin chaperone cofactor A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL25203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="118" mass="13260" checksum="ED8FEB4EF43E74B8" modified="2015-09-16" version="1">MAPRSQLEITTSSVTRLVKEEASYHKELQQQTERIKKLEADAAGDDENREYTLKQEHMSLEETKKVLPTLKEKIVQTVANLEALIIEEGKKGSESNVEHITAAKEAIAQAKTAQREIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PG41</accession>
    <name>A0A0G4PG41_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S014g000126</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Sterol O-acyltransferase that catalyzes the formation of stery esters.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PG41"/>
    <dbReference type="STRING" id="1429867.A0A0G4PG41"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF7">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000439">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="456"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000439-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CRL25230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="498" mass="56099" checksum="D5E29F58836B9FDE" modified="2015-09-16" version="1">MTTRTGAITRAREESQVNSTNGALPAVTEVSPPSTSTSKKRSKYRHVAAYHSEARHSSLSREADVLPNFLGFRNLMVLVLVAMNLRLIIENFMKYGVLICIKCHDYRKQDVVLGSILFASVPCHLLVAYIIELSAATAAKQTVGRQKKTEKEKEHDQKVFQSTWPYTAFLHTLNATLCLTVTSFVVYFYIHHPGIGTICQLHAIIVWLKNCSYAFTNRDLRLALLNPSADPGLPEIYSSCPYPRNITINNLAYFWLAPTLVYQPVYPRTASIRWSFVAKRLAEFVGLAVFIWLLSAQYAAPVLRNSIDKIAVMDIASILERVMKLSTISLIIWLAGFFALFQALLNALAEVMRFGDREFYTDWWNSSSLGMYWRSWNRPVYLFMKRHVYSPLVGRGWSPLAASGMVFTLSAILHEMLVGIPTHNFIGVAFFGMMFQLPLISLTAPLDNMRGPEGRVIGNCIFWVSFCLVGQPLGALLYFFAWQAKYGSVSRMVPNVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PG91</accession>
    <name>A0A0G4PG91_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S014g000225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PG91"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL25329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="440" mass="48880" checksum="ECB40E21CB2208BA" modified="2015-09-16" version="1">MPPKPSSRKGVKKGMSHTLSPHPSSSPIRKKQKGTKSVISERANSSPLPGVPKTDSSAGTQPPSEYWNQLTDLQQAFLGSVTQQTGSKLHDFGTEIKTEMPSPTPASVTNDANESEYSFDLTPVPGPISSSFPCTEDDLTLCHAPTADPTGYPIFVSRNGLWDWYYLSSNNHIESSATPVNETTNGNAKSTKSEFANGLSFSPDQFPCTEDDMTLFPCPNYAHGPTFSSQNGRWEWIFLPSNTDTESSPPKVKMEDIPEANPRVQRPGNPVSTPFSAADLERFVFPYSVVPDSDDDISSVPSLVENIAEQARTAKYVRFFMNTTHDKHFVPIEVPPLTGNNNWDPWLAAMRLLFRQHSVWPVVTAELQPLTPGHNLYLWYERMCDCAIALIYANVSEEVRRTPCFMSTAREDDADVLMSHLYAHYSEPDSTHSHEESELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGF5</accession>
    <name>A0A0G4PGF5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Protein phosphatase methylesterase 1</fullName>
            <shortName evidence="7">PME-1</shortName>
            <ecNumber evidence="7">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S014g000310</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Demethylates proteins that have been reversibly carboxymethylated. Demethylates the phosphatase PP2A catalytic subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O = [phosphatase 2A protein]-C-terminal L-leucine + methanol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48548"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="3.1.1.89"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PGF5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PGF5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051723">
        <property type="term" value="F:protein methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000186">
        <property type="entry name" value="Protein phosphatase methylesterase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016812">
        <property type="entry name" value="PPase_methylesterase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022950">
        <property type="entry name" value="PPase_methylesterase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="10">
        <location>
            <begin position="107"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR022950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR022950-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL25414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="426" mass="46782" checksum="849800546C828C94" modified="2015-09-16" version="1">MSDLQKSYAKSKLAKFPPEAPMPESMSYSEDAWEDGSSASSLSSTGTMVPSPTRQLFARTGRRQSSQTSLTWTDFFDQELFLPEDVDNLHIVHHVYLTPPTESGPLFVMHHGAGSSGLSFATCAEEIRKILPKAGILSLDARSHGRTVVTTLESKTGDNAPYTAAAAQAESSGQVELDLRLETLSRDLVHVIHQTQTRMGWEKLPDIILVGHSLGGAVITDVAKKGELGPKLLAYAVFDVVEGSAMDALQSMEKYLSTRPTRFPSLISGIEWHTRSRTIRNTTSARASVPSLLYEESEPSDPSRPWVWRTNLSATKPFWENWFVGLSRKFLDARGGKLLLLAGTDRLDKELMIGQMQGKYQLQVFPEAGHFVHEDQPAKTAQILADFYRRNDRSALVLPPKVADMQASAAMKKGTGAPGGSTGHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGG2</accession>
    <name>A0A0G4PGG2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger, C2H2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S014g000278</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PGG2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PGG2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF19">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="360"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="391"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="425"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL25382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="483" mass="52713" checksum="36D0AEE28CD9EEEE" modified="2015-09-16" version="1">MYDSDDAFNKSPPMEAIKPNYGENETPPPPFASISEKDDAGSRKPNQPKPQSSTREGDRVLMGFLAPNHPEIAATARLAPLEPLPGNLKNYRQPPDFDPRGRSNPFSRDDPPRKASLELTTSGPGLASHKDTESKPPQKRLFPAPLQPKEPDVEIKTEIQRERVPSISGLSQRSPQGLPYLKTSSEIKSEFPLPSLKLSQPASGSSFAKSPDGCNKQTLPSIHKAISELSDFGPPVNTIPSPYPFSSCPGSTTSGNDSPFDRAFPGKFSIPASPFSHFSPVSLKDSSTHPSPASHSSFWRGTPQSEMLSVQTPYEASPMTAKSPATSYPTPTEQVGVGMGDRHPLAVSTPQANGGPVGSYKCTHPGCTAAPFQTQYLLNSHANVHSQDRPHFCPVEGCPRALGGKGFKRKNEMMRHGLVHNSPGYVCPFCPDQQHKYPRPDNLQRHVRVHHVDKNKDDPILRQVLAQRPLGSARGRKRRMNNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGM2</accession>
    <name>A0A0G4PGM2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc finger, C2H2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S014g000276</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PGM2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PGM2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="390"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="261"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL25380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="423" mass="46415" checksum="C5775C5EE2308FCC" modified="2015-09-16" version="1">MPERFPPKGSFEYVDWEFSFASPEELSFHNIIYIPDIPNVANMYPSRQKSKSTYGTVPDSTGYSEPLDPQHLGGLTNIPTSAPCSSRMPALQQVGFMDTQPDPRSFLSPGHYPKGRRGSTDTDTIGSQYAWSTASNAEILSNSPHMRSFETPIGPTTSPFIQGYYPPGSLPLAMSGPGVSGYTPQQIDKWCIESEPAQDFYHSQPFANMGSMHFPPSIEVQPKPYPTFNAQLNTANEQWFPCPPHSSDPIPETFFSVPRSVSATRSVPTPTPHLYQSTTTTSITSSPPHSLSDPDSPPAAPGSASGSGSGSNSGDLSNYGIPTGDGNWRCAHPGCSSQAVFHRGCDLRKHFNRHRKHLFCRYEGCPQSAKNGFSSKKDRARHEAKHNPGVFCEWEGCGKVFSRVDNMKDHVRRIHRKGESGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGW1</accession>
    <name>A0A0G4PGW1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NADPH-dependent diflavin oxidoreductase 1</fullName>
            <ecNumber evidence="11">1.18.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">NADPH-dependent FMN and FAD-containing oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TAH18</name>
        <name evidence="14" type="ORF">PCAMFM013_S015g000162</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of DRE2, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. Positively controls H(2)O(2)-induced cell death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2 oxidized [2Fe-2S]-[protein] + NADPH = 2 reduced [2Fe-2S]-[protein] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67716"/>
            <dbReference type="Rhea" id="RHEA-COMP:17327"/>
            <dbReference type="Rhea" id="RHEA-COMP:17328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with DRE2; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Mitochondrion</location>
        </subcellularLocation>
        <text evidence="11">Relocalizes to mitochondria after H(2)O(2) exposure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.-" evidence="11"/>
    <dbReference type="EMBL" id="HG793148">
        <property type="protein sequence ID" value="CRL25576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PGW1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PGW1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160246">
        <property type="term" value="F:NADPH-iron-sulfur [2Fe-2S] protein oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000013">
        <property type="entry name" value="NADPH-dependent diflavin oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000015">
        <property type="entry name" value="NADPH-dependent diflavin oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000030">
        <property type="entry name" value="NADPH-dependent diflavin oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03178">
        <property type="entry name" value="NDOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028879">
        <property type="entry name" value="NDOR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF10">
        <property type="entry name" value="NADPH-DEPENDENT DIFLAVIN OXIDOREDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="4 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 11" id="KW-0288">FMN</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 11" id="KW-0521">NADP</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="12">
        <location>
            <begin position="14"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="13">
        <location>
            <begin position="227"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="20"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="67"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="406"/>
            <end position="409"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="445"/>
            <end position="448"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="555"/>
            <end position="556"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="561"/>
            <end position="565"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="642"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CRL25576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="642" mass="72252" checksum="B93090487DD6C973" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PH31</accession>
    <name>A0A0G4PH31_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tetratricopeptide repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S015g000214</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in endocytosis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YPP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793148">
        <property type="protein sequence ID" value="CRL25628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PH31"/>
    <dbReference type="STRING" id="1429867.A0A0G4PH31"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051722">
        <property type="entry name" value="Endocytosis_PI4K-reg_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083:SF464">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT DOMAIN 7, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN, TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="627"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="703"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1045"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="801"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL25628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1157" mass="127309" checksum="B9FA55AA78C251DE" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PH61</accession>
    <name>A0A0G4PH61_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BAR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S015g000244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793148">
        <property type="protein sequence ID" value="CRL25658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PH61"/>
    <dbReference type="STRING" id="1429867.A0A0G4PH61"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="2">
        <location>
            <begin position="15"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL25658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="436" mass="48939" checksum="77AAE1961B6E7ADA" modified="2015-09-16" version="1">MHVNKRIGRFKQWAGERMGGEAKTCLSDDFKAMETEMGVRHEGVDRIHKSMTSYVKAISKRNEGDDKEKTLPIAHLGSSMVAHGEDFDGNSEYGQCLITFGRTEERIARIQESYIAQATSSWLESLERSLTQMKELQQARKKLDSRRLAYDTSLSKMEKAKKEDFRVEEELRSQKVKYEEASDDVLRRMQDIKEAETDNVMDMGAFLDAQLEYHERSREALLQLKNEWAGYSQVQAPPRRPTRPRANTAHSYQERYEPLQEELMNATDTRPPPIRSNRSITPYAESPPRETYGNTSGVTRPVLSRVPTFEGPAQLRQEQSPVASQWVQQRTTSENLGGFGRRSSTQVGSGRLSADPYADSEEVSSYGRSSPERMFGGGRSISPATSHGSVPSRRPSATNLNTMGLKKAPPPPPPSRAKKPPPPPPVKRSLLAAPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PHQ3</accession>
    <name>A0A0G4PHQ3_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytoplasmic tRNA 2-thiolation protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">NCS2</name>
        <name evidence="3" type="synonym">CTU2</name>
        <name evidence="4" type="ORF">PCAMFM013_S016g000072</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTU2/NCS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793149">
        <property type="protein sequence ID" value="CRL25791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PHQ3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PHQ3"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03054">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019407">
        <property type="entry name" value="CTU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882:SF14">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10288">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL25791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="369" mass="41014" checksum="9560D724BE081145" modified="2015-09-16" version="1">MPAKELNKPCMECKDAEFELTVRKRQLCSLCFKRFIAHKVQSRLSVYRAFGLDGPKTQLLLPVSFGVSSSVLLHILNTDRQHRLDNGRPLGYDFKILVIEPSTVTATGIPFDQNYEALEKNFPMHTISRIPFHSIFDYVPEMEEIMREYAGSRFIDDSTRSNEERLAAFRASISTSTSRTDVDTVLLTRLIVEFAKKSGCESVIWGDSDSRLAAKALAGVAKGRGASLTWQVSDGMSPWGVRFEYPLRDLYKAELLQYESVCAELSDIVIPDQPPSDNVLTKNLSIDELMLRYVQNQGAKYPGVMANVARTANKLNPSTSDNAPTCALCAGLVGNVKGNSGVTVANQAEDNHSSQFCYGCMRSRPEELC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PHU0</accession>
    <name>A0A0G4PHU0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S1, IF1 type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S016g000135</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EIF1AD family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793149">
        <property type="protein sequence ID" value="CRL25854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PHU0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PHU0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039294">
        <property type="entry name" value="EIF1AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21641:SF0">
        <property type="entry name" value="RNA-BINDING PROTEIN EIF1AD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21641">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1-like" evidence="4">
        <location>
            <begin position="26"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL25854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="138" mass="15758" checksum="627045C6AB5A3E71" modified="2015-09-16" version="1">MGPPRRKMLATAEGTLTPPDELSDTQQIVRAIKATGNNIYLVEQTDKQQMLVELPARFRSAIWIKRSSYVVVDTKGQEERDNKIRGEIVNIVRDEKAWRKAPFWPKEFVKQPVVLAADSDDEEEESRVGRMPSSDESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PIU5</accession>
    <name>A0A0G4PIU5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylglucosaminylphosphatidylinositol deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S017g000099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIGL family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.89" evidence="2"/>
    <dbReference type="EMBL" id="HG793150">
        <property type="protein sequence ID" value="CRL26116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PIU5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PIU5"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000225">
        <property type="term" value="F:N-acetylglucosaminylphosphatidylinositol deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF11">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL26116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="307" mass="34053" checksum="6BE2A341225C79FD" modified="2015-09-16" version="1">MSTSFNWTALAVAITAVFIFWTFSSTSSSPFTRSFPRLENKRICLLIAHPDDEAMFFAPTVLSLTKPELGNHLKILCLSSGDADGLGETRKQELQKSAKQLGLRSESDVFIVDDTTRFPDGMDKDWNEDQISSLLASAFAPEMAALQKLPGKRVDRNKAPTATIDVIITFDKHGISNHPNHRSLYYGAVNFVRALMKDKAGFTSPVTLYTLTTTSVFRKYAGVLDAPVSMFLGVWSNLVAGLTGSRKKEAGAAAGPVRLLFVSSINEWLTALSAMVNCHKSQMVWFRWGWITIGRYMTVNDLQREKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PIU7</accession>
    <name>A0A0G4PIU7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="18">SNF2-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PCAMFM013_S017g000104</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793150">
        <property type="protein sequence ID" value="CRL26121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PIU7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PIU7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF22">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24975">
        <property type="entry name" value="UBA_Rad5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="522"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="914"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="1020"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="393"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="978"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1089"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
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        <location>
            <begin position="396"/>
            <end position="411"/>
        </location>
    </feature>
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        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
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        <location>
            <begin position="978"/>
            <end position="996"/>
        </location>
    </feature>
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        <location>
            <begin position="1099"/>
            <end position="1108"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL26121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1219" mass="135761" checksum="2E8DEFA9F95B8DBE" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJ29</accession>
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        </submittedName>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CO-CHAPERONE PROTEIN DAF-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932">
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    </feature>
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            <end position="223"/>
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            <begin position="137"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="223" mass="24027" checksum="460250647E6BA69D" modified="2015-09-16" version="1">MSQTLTPEVTWAQRSSDSDPERNYLYVNIKAAEVPKADATLSITEKNVSFKGTSRKGVTYNVSLDLFAEIDPENSKVNHTDRDVELVLRKKELKEEFWPRLLESKQKMHFLKTNFDKWVDEDEQDEAGEDDYANNFGGFGGEGGGDPNAGPGAGGLGNIDFSKLGGMPGMGGMGGMPDLSALAGGMGGMPGMPGGEGAEEDDEDLPELEEADGQKSTKIQEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="bZIP transcription factor hapX"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018287">
        <property type="entry name" value="Hap4_TF_heteromerisation"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF7">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10297">
        <property type="entry name" value="Hap4_Hap_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="5">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="25"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="160"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="228"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="413"/>
            <end position="439"/>
        </location>
    </feature>
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        <location>
            <begin position="81"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
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        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL26449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="509" mass="54625" checksum="BFCB0E097B5325CC" modified="2015-09-16" version="1">MASGVSMAPAPAGVPALALAPAPTLAARPSVAPSPGPGTPGSITSREWVIPPRPKPGRKPATDTPPTKRKAQNRAAQRAFRERRAARVSELEEQMKEIEDSHDIQVASLQQQIGNLSGEVDQCREEMGWWRDRCHALEKEVSIERSAKEALVKEFRSSLAGPNVSKPAPIPDSVPLPPRKTRSSRMEDVQPTSTERNKEDGQINVPLGCNNCSNAHCQCIEDAFGMPMDTHESSRSRHSPHGVGSPERDHRDPHIKPDPEEMEIDFTAQFSSVPTQSNDHDVSSPPVDPCGFCQDGTPCICAEMAAQEQQRVRNINTFETNRLAPIQSISQFTPPPSEGDVRSEVTLPPISQATNPCANGPGTCAQCQADPRSTLFCKTLAASRSASGTPSGGGCCGGGGKDGGCCMSRNAPAAAPKPRNNATMPSQPPAPKPAPPSELTLSCADTFTTLSRHPNFNRASDEISTWLPKLHTLPDPRDIAPADSRGALEVEAASVMGVLRYFDRRFAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PK86</accession>
    <name>A0A0G4PK86_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase, DXD sugar-binding region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S019g000196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CRL26779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1429867.A0A0G4PK86"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF9">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195420" evidence="2">
        <location>
            <begin position="30"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL26779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="398" mass="45857" checksum="7799A49D4DFD23FA" modified="2015-09-16" version="1">MVFLGSPNRHKYVLVAAILTLFILFKSVPTPTSRLDPRNEKSYGEHRPRYLHQSTFRANPDYEYEINLSNALRAMEIEREMRHDEDATDTLWQIMLPGVSERSDDSIQFEQKNSEWKYKLVQADWADKFIFETLESIPDIARLYKSYPHSVHRGDLLRYLILWYYGGYYADLDVYPARSIKSCPSLRHSLFKDNSVNANVSLVVGIEIDEPFASPQKMRDWHWARRYGFIQYTMYAPQRFSPLLREIIVRVLSHTKKRVDGSHFWSGRYNEMDTLEITGPGVFTDAILDALSDTLPSTHRLVQQSADADAKFSSSASSTQRVTWAPFHGIQEPVCVEGPEAKAGKLLGGLCVLPVNAWGNGQRHSGSEDFNSHHACINHRFGGTWKPWKQSWQKYLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PL35</accession>
    <name>A0A0G4PL35_PENC3</name>
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        <submittedName>
            <fullName evidence="7">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S021g000055</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793154">
        <property type="protein sequence ID" value="CRL27140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PL35"/>
    <dbReference type="STRING" id="1429867.A0A0G4PL35"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000224">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF29">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06680)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="487"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="265"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL27140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="562" mass="62136" checksum="346787357FD05F46" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PL47</accession>
    <name>A0A0G4PL47_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger, C2H2-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S020g000035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793153">
        <property type="protein sequence ID" value="CRL26876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PL47"/>
    <dbReference type="STRING" id="1429867.A0A0G4PL47"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021842">
        <property type="entry name" value="DUF3435"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535:SF2">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535">
        <property type="entry name" value="FLUG DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11917">
        <property type="entry name" value="DUF3435"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="935"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="646"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="842"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL26876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="981" mass="113744" checksum="6CBB466B681AA239" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PLA4</accession>
    <name>A0A0G4PLA4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S020g000095</name>
    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Eurotiomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793153">
        <property type="protein sequence ID" value="CRL26936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PLA4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL26936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="141" mass="14976" checksum="B6DEED45F354B6DB" modified="2015-09-16" version="1">MSMCIPLKRSSNPQSIEAITTLNTITITITSIPIPHLPPKKQSPINPHSPIPNLLAIVVSLQFRSRENRSLVGMVISGHLDRDAQGVIMMFGMDGDGGGAGSNVSCDCAHEGLVVGVGVPCLDEDVHPVADLAWIVLGFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PLB3</accession>
    <name>A0A0G4PLB3_PENC3</name>
    <protein>
        <submittedName>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
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            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL27222.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="165" mass="18523" checksum="0C88D8D44357C93C" modified="2015-09-16" version="1">MTSLLTTLGLRASLNPNSNHGPIFLTFNFILAYGLLSSRTLKQWYGLDHQVSPREDLTKYGEAAVREGKITRRQLDMLKRNESAHANAVENFPLLVAGVLFASLVGVPARRINAAALSYTVARVVYGAVYIFVDHPTWSQVRGLVWWWGNVSCFFLLWKAEELLA</sequence>
</entry>
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    <accession>A0A0G4PLQ8</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="344"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="1140"/>
            <end position="1178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL27116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1477" mass="167924" checksum="F2C16FEAAFAA8D9C" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMR6</accession>
    <name>A0A0G4PMR6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S023g000200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793156">
        <property type="protein sequence ID" value="CRL27742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PMR6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL27742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="265" mass="29073" checksum="90DE73F877568978" modified="2015-09-16" version="1">MATTRIRVKQILQSPLPPLNQGSSKTSSSALHRLRYVGSLGLWPNFQNQVEAAYNAQTFSRSITSPVSPGPHQVEPDIVSVGDEHGLQGRFQQAIGQVLGVALEAQGINLSFGDFKCSGIIYENIPDVIGLSRTIQGNVELSLIGELKVPWVLAHSISDAYHTPKGLRRLLGQPLLYMRDLGSAYGFLSTYEETIFLYQTQLANGQWHVEYSPVVWSTDIYEPSQGPSSIPSVSMRQCMFYVAGLASQHGPVSNQTPASQWVVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMU3</accession>
    <name>A0A0G4PMU3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S024g000025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793157">
        <property type="protein sequence ID" value="CRL27770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PMU3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PMU3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL27770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="320" mass="36069" checksum="7CB9C66DDCE7C6AF" modified="2015-09-16" version="1">MPYLSEPTVLLPDLQGPAKNGIPSYLLRVYTSPDVFPPAESLPDQQGSPLDPFSKLPAAVNAILNTHMRGKMGPGYQYSNMTSWTRSMLVALQDGLMKIPRDLHSPAASNVFLLVIDTGKFPSGTFIKDSELVGEIKRHISESEGKPLGDFLAIRRSNMETHSGEYLSLGELNIEGKCIQISFQELISNGLFNLHVHLGKECHPNDWMTRVSELRRPFGLLHEPPRAKTSEIFTAIRIGCYFRQDQWAIPVAMMLLALKPRKGDDSAIMQAFSKWFSDSDVLLLRGYQFDLNAADIDQLPEVKQYTRLLYDLVCHFYQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PP11</accession>
    <name>A0A0G4PP11_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Taurine catabolism dioxygenase TauD/TfdA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S025g000182</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793158">
        <property type="protein sequence ID" value="CRL28124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PP11"/>
    <dbReference type="STRING" id="1429867.A0A0G4PP11"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF10">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="25"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL28124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="347" mass="38648" checksum="60BC4A12D965A9A4" modified="2015-09-16" version="1">MPIEDFITSFPAPLTLGSSIDHWKYEDLTRTLGRVYSGIDLAEVLNAPNADELLRDLAITISHRGVIVFRDQKNLTADQQKFFTHRLGQLTGKPEESGVHIHPINHTIHKEGEKPDLEMSTIARNPENMLSKQSGVVAGKKTLKKQSVADGWHSDIAFERVTSDYTTLVNKVRPSTGGDTVFASAYEVYDRISPPWRAFLETLTGTFSPVGYSPNPDHTHLYQVARGHPNNVDQSLTAEHPIVRTNPVTGWKSIFGVGHHLQAVNGLAPDESEHIKSYLMKLITDNHDLQARVKWEVDDLAVFDNRAVYHTATYDYDEPRVCLRVVAVGEAPALDPKGVSRSDALDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPT9</accession>
    <name>A0A0G4PPT9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Longevity assurance, LAG1/LAC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S026g000041</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793159">
        <property type="protein sequence ID" value="CRL28176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PPT9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PPT9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF11">
        <property type="entry name" value="CERAMIDE SYNTHASE LAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="246"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="349"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="12">
        <location>
            <begin position="162"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="387"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL28176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="441" mass="50678" checksum="E74D301FE36260ED" modified="2015-09-16" version="1">MVRPRGSSALGVDIRGDTSAPAMSTMNEVSPIEPTSPGLKQFDGAHKQASKAPTKRRRARSLLHRFADTCLRYTWLLPLFIMLFLIALYAINPTTSNPMHSAIFLSYPQPPKTPGGPIMYGKGKKDIAFVAFYTIVLSFTREFIMQQMIRPFAVWCGIRGKGKTARFMEQAYTAVYFGVFGPFGLYVMKRSTIWYFNTTAMFEGFPHREHEGLFKAYYLLEASYWAQQAIVLMLQLEKPRKDFKELVGHHIITLALIALSYRFHFTYMGLAVYITHDISDFFLATSKTLNYLDAYITAPYFAMFVGWWIYLRHVLNLKILWAVLTEFRTVGPFELNWETQQYKCWISQYITFSLLASLQAVNLFWLFLILRILANYIFTNVTKDERSEDEEEEEELEPVNATKAIATGTDQTGKENHAPQVLINGEPVAEQRGPRTRSRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQ18</accession>
    <name>A0A0G4PQ18_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Ribonuclease P/MRP protein subunit POP5</fullName>
            <ecNumber evidence="4 10">3.1.26.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S026g000121</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP, which cleaves pre-rRNA sequences.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the eukaryotic/archaeal RNase P protein component 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="4 10"/>
    <dbReference type="EMBL" id="HG793159">
        <property type="protein sequence ID" value="CRL28256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQ18"/>
    <dbReference type="STRING" id="1429867.A0A0G4PQ18"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030681">
        <property type="term" value="C:multimeric ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3250:FF:000004">
        <property type="entry name" value="Ribonuclease P/MRP protein subunit POP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3250">
        <property type="entry name" value="Ribonuclease P, Pop5 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002759">
        <property type="entry name" value="Pop5/Rpp14/Rnp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016819">
        <property type="entry name" value="RNase_P/MRP_POP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038085">
        <property type="entry name" value="Rnp2-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15441">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15441:SF2">
        <property type="entry name" value="RIBONUCLEASE P_MRP PROTEIN SUBUNIT POP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01900">
        <property type="entry name" value="RNase_P_Rpp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023803">
        <property type="entry name" value="Ribonuclease_P_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160350">
        <property type="entry name" value="Rnp2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR023803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL28256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="192" mass="20808" checksum="3FC9362EEC0C47CB" modified="2015-09-16" version="1">MVRLKNRYLLVDILYPDPKTWPTTPTTKPHNPQLAIHSPTSDALTQGFLAKMIRESVAELYGDYGIGKLGGASAGGITIKYLSPATSTAIVRCPRASFRLVWSALTYMSGVPEPANGPKRAGTGRERGCVFRVIRVSGTMRKAEEEAIRRARREIVRVKDAEERGVLGGLVGGGSAVVDCVMDESEDEGMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQ50</accession>
    <name>A0A0G4PQ50_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA recognition motif, RNP-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S028g000115</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RENT3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793161">
        <property type="protein sequence ID" value="CRL28562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQ50"/>
    <dbReference type="STRING" id="1429867.A0A0G4PQ50"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12455">
        <property type="entry name" value="RRM_like_Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000637">
        <property type="entry name" value="Nonsense-mediated mRNA decay protein Upf3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039722">
        <property type="entry name" value="Upf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005120">
        <property type="entry name" value="UPF3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112:SF0">
        <property type="entry name" value="FI21285P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112">
        <property type="entry name" value="UPF3 REGULATOR OF NONSENSE TRANSCRIPTS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03467">
        <property type="entry name" value="Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="405"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="204"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="475"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="219"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="475"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="503"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
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        </source>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="CRL28562.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="543" mass="56979" checksum="69AF54965F74EB68" modified="2015-09-16" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
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                <person name="Debuchy R."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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            <end position="125"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL28333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="266" mass="29547" checksum="AC70509F6BB588D0" modified="2015-09-16" version="1">MSANLMSRTPSTATPTWHHFERKLEEVKPSKTDINYLVMDYLITNGYPAAAKKFAVEANIQLRTDLEAIQERVEIRTAIHSGDIQAAVEKINELNPQILDEDPSLHFALLRLQLVELIRTCMDTPGSDITPALDFATAQLAPRAPTNPQFLADLERTLALLIFPSDKLAPSLASLLDPALRKEIATRVNEAILQNQGARKEARLRNLVKTRAYAEQKAREAKKDIPDTLDIGLVGDSHDNSNSNDLATNIRDTLMSNNSDIDPMIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="170"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
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        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL28680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="290" mass="31964" checksum="C57F8929A635FFC8" modified="2015-09-16" version="1">MSDPTMNSPDNGSHKRKRDGSEDLGPDPQRLNRSSHGSNGSMDNQHNFGHGGLGNYDHGLPNTGAELNIDQQILQHVGPQNGLSDDNALTANAKAALAAHTPQHKYPPPPDSGFDASNLTQGLSFGDEMNQTPMGGGHNHNSTAAAVYAAREAQSMNQKPTVGSPEWHQIRKNNHKEVERRRREAINEGINQIARLVPNCDKNKGAILQRAIEYILQLQEEKKNIDEQFEKHSLTANHAIAEISGSNSKLKGEVARRNNIALKWLSRCRDAGLDFDDYEESKELESLEMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQW4</accession>
    <name>A0A0G4PQW4_PENC3</name>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
                <person name="Silar P."/>
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                <person name="Sallet E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793163">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL28804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="105" mass="12399" checksum="686124694AA0869C" modified="2015-09-16" version="1">MLLNRFYCTRCAISFRTFFARLQHIYDSPYHHICYICFPPQDFAKMVELDEHLGTEHNYCISCDIQFETAQNLAQHDIGEHNMCVTCRQFFGSRSSLSNHMTTHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRY4</accession>
    <name>A0A0G4PRY4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Amine oxidase</fullName>
            <ecNumber evidence="11">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S033g000117</name>
    </gene>
    <organism evidence="15 16">
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="11">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="10">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10 11">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="11"/>
    <dbReference type="EMBL" id="HG793166">
        <property type="protein sequence ID" value="CRL29197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PRY4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PRY4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000026">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF33">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="14">
        <location>
            <begin position="5"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="13">
        <location>
            <begin position="243"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="661"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="9">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="10">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CRL29197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="680" mass="76243" checksum="99373A1E6D417552" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PS01</accession>
    <name>A0A0G4PS01_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S034g000027</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793167">
        <property type="protein sequence ID" value="CRL29229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PS01"/>
    <dbReference type="STRING" id="1429867.A0A0G4PS01"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="18"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL29229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="797" mass="88370" checksum="FBA0F9B8D0CC3FDE" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PS58</accession>
    <name>A0A0G4PS58_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S032g000014</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793165">
        <property type="protein sequence ID" value="CRL28978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PS58"/>
    <dbReference type="STRING" id="1429867.A0A0G4PS58"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019510">
        <property type="entry name" value="AKAP7-like_phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF163">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10469">
        <property type="entry name" value="AKAP7_NLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
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        <location>
            <begin position="46"/>
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        </location>
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        <location>
            <begin position="81"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="47"/>
            <end position="472"/>
        </location>
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        </location>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL28978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="921" mass="101925" checksum="E0520E7FBB12D152" modified="2015-09-16" version="1"> </sequence>
</entry>
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    <accession>A0A0G4PT41</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
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                <person name="Debuchy R."/>
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                <person name="Silar P."/>
                <person name="Lacoste S."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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    </dbReference>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL29845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUB9</accession>
    <name>A0A0G4PUB9_PENC3</name>
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        <submittedName>
            <fullName evidence="5">Str. FM013</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="5 6">
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793175">
        <property type="protein sequence ID" value="CRL29993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PUB9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PUB9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056634">
        <property type="entry name" value="DUF7732"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42091">
        <property type="entry name" value="CONSERVED GLYCINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_7G02440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42091:SF1">
        <property type="entry name" value="CONSERVED GLYCINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_7G02440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24866">
        <property type="entry name" value="DUF7732"/>
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            <end position="18"/>
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        </location>
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        </location>
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        </location>
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        </source>
    </evidence>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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                <person name="Dupont J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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            <end position="211"/>
        </location>
    </feature>
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    </evidence>
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            <dbReference type="EMBL" id="CRL30335.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="211" mass="23229" checksum="1E3E8907FFEB230E" modified="2015-09-16" version="1">MHSILAISLVLSLALFSTAALNPCSFATNDMSLTEAQLIQIAPQSKSCDDAPAKGECATAKTAADSISQSFNTYNVTNKAEQVAILSLMAFESNDFKYNKNHFPGILGQGTRNMQSPAFNKKYAKSIPELKSRFYFVENIPADLLDLLRENKTYDFGSGAWFLTTQCSKEVRSALQDGSEKGWKNYITIRGVSGVICCIWLLVESVIWVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVI0</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Dupont J."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </reaction>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03763">
        <property type="entry name" value="proteasome_beta_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000005">
        <property type="entry name" value="Proteasome subunit beta type-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024689">
        <property type="entry name" value="Proteasome_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF4">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12465">
        <property type="entry name" value="Pr_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
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        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8 13" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0888">Threonine protease</keyword>
    <feature type="domain" description="Proteasome beta subunit C-terminal" evidence="12">
        <location>
            <begin position="222"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL30184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="277" mass="30032" checksum="B9EF3D0A57DE389A" modified="2015-09-16" version="1">MPGFDFTNYNRNAALHARGVPLPKATSTGTTIVGCVYDKGVVIAADTRATSGPIVADKNCEKLHYIAPKIWCAGAGTAADTEFTTALISSNVELHSLSTGRDPRVITCMTMLKQHLFRYQGHIGAYLVVAGVDPTGTGLYTVHAHGSTDKLPYVTMGSGSLAAMSVFESTWQPNLDRQGAIDICAEAIKAGIFNDLGSGSNVDVCVIEKDQPTQLLRNYMKPNERPQKERNYRFPRGTTAYLDQRVISKEDMKKYVTIETLSGDDNLATGDSMEVDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVR0</accession>
    <name>A0A0G4PVR0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793179">
        <property type="protein sequence ID" value="CRL30242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PVR0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL30242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="286" mass="31980" checksum="AE9F6898053A0BAF" modified="2015-09-16" version="1">MATGFPAWTHNLSTPLPLDRVPRHIRLVGVSLNIPSGQKGPASPQAEAHVGFHSHGKAIISQNIDEYALINHTIGFHGQEAFSNMEKSYKRVAIPSQAVHQSLKTQKHNGPNSCVPLQFSSLPANDNTARGLLSTKSPLPSTHCKRIFPVESDFSLIDKSVARNNPALENILSNLKRCDAALLESFYRSAFQGLDQDTCEAILHLWIRALSPKALVGIQNTYSRELTYPDTREVLCHILRGRPGEGIPFKWLLATLRLVSIEGKKRVEVETRLLLREIEVWRELYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVU3</accession>
    <name>A0A0G4PVU3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S053g000021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PVU3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PVU3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL30513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="67" mass="7872" checksum="6377173A89E50AB8" modified="2015-09-16" version="1">MEALINDPQSLELDVLLIQEPSITTYRTHINHSAWRLYRPTIQTEAVRFRSLLMSIEEFLPHHIANT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PW08</accession>
    <name>A0A0G4PW08_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Scytalone dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S055g000024</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the scytalone dehydratase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793188">
        <property type="protein sequence ID" value="CRL30609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PW08"/>
    <dbReference type="STRING" id="1429867.A0A0G4PW08"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030411">
        <property type="term" value="F:scytalone dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006582">
        <property type="term" value="P:melanin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00531">
        <property type="entry name" value="NTF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004235">
        <property type="entry name" value="Scytalone_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049884">
        <property type="entry name" value="Scytalone_dh"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02982">
        <property type="entry name" value="Scytalone_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF024851">
        <property type="entry name" value="SCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scytalone dehydratase-like" evidence="6">
        <location>
            <begin position="16"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR024851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR024851-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR024851-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL30609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="171" mass="19890" checksum="5008E7BC5896392D" modified="2015-09-16" version="1">MSPAVKNNTTEPNLDISFQDYLILSKLVFDWADSYDSKDWDRLRSIIAPTLKVDYTEVGLTKWDSMAADEYMAMITHTGFLGDKTVKTQHLLGQTWWEKVSDTEVIGHHQLRAAHQVYETEELKTVKLRGHGHATNEHYYRKVNGVWKFAGLKPTVRWNELRYDEVFKGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PW61</accession>
    <name>A0A0G4PW61_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S058g000029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793191">
        <property type="protein sequence ID" value="CRL30752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PW61"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="379" mass="43030" checksum="72DCF2B51B64AC9D" modified="2015-09-16" version="1">MAAKGSSVLKRSTSDRMKISSLLNEQTLPCPQNVLASPHKLRQGHGSVRFLAVNNSTSSVHEDGKFTPPIDVEEPSSASFQGRERCVASQDESAATSEDTWPASGRRRDATAITGDKNPGARSKRRRGANEALEIERHLVDIPKLETTQSVVVTPPVHPSQKRGYTKEETHFIWYYHVVLLEKWEDIHKSFNDNFTSRSDPSCLRDKLRQLVMKGDLPARPKKDHEQTHNGEAGQAISHAAIEDVLQRCASLGYLWMKEASRIAGSQTTQSVMVRPTIRPRKYTEEEVHFIWYYRVALSKNWRNIHKNFNHRFNPRRSSSCLHEKLRQLVMKGDLPDRPKKDHEQTHDGEAGQAISHANIEEVLQRCASLGYPWMEEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PY40</accession>
    <name>A0A0G4PY40_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S169g000002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793299">
        <property type="protein sequence ID" value="CRL31382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PY40"/>
    <dbReference type="STRING" id="1429867.A0A0G4PY40"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL31382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="179" mass="20414" checksum="599F7D14E0F4D34D" modified="2015-09-16" version="1">MVETKIRNGINHINKLNFLEVYPLTRIEAFKSETIKNSFLAAGLVLFRPDRVILKLNIRLRTLTPLASRGSDLSRNFTLKTLFTQKDLYRQALSIKALLPQEIKELRAANKKQKQKRTRSRRQIPAEEGLLVQEASALIMQQQEAIEAPPPSPGMPRESTIQPRTRPPPGVWNIQIARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PZ08</accession>
    <name>A0A0G4PZ08_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Actin cortical patch SUR7/pH-response regulator PalI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S155g000002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793285">
        <property type="protein sequence ID" value="CRL31378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PZ08"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF2">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL31378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="288" mass="31477" checksum="7AD7A6D7CE560E77" modified="2015-09-16" version="1">MKFSARSRLDQLVSTTALSFSVAVLVCLSFVFVGCSSPSSPRGLHFLKVDLEEFPKLRDLRIRNSFNINDAPITRGGRNAVEGVLSSIDTSPKDAINAATSAASDTIQAQIHDLKSHLPRYYIVGLWSYCKAQNGPEMVCSDPSTSFSFDLSAVLDSAPKRVSDILPDIDQSLISGYRRFSQSVIWMYICGFVTTTLTLVLAGRKLFLSKGSSLLAIFCALSSMLITTATFVVTVMYGVFTSKIRSTLQSYGVEAILGAKMFTTAWLAVFFSIGCSTIWLVHLFCCCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NT82</accession>
    <name>A0A0G4NT82_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mov34/MPN/PAD-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S001g000231</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NT82"/>
    <dbReference type="STRING" id="1429867.A0A0G4NT82"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000001">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056263">
        <property type="entry name" value="RPN11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23594">
        <property type="entry name" value="RPN11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="9">
        <location>
            <begin position="35"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL17271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="334" mass="37407" checksum="4554E698C755E2BB" modified="2015-09-16" version="1">MDRLNRMLQAAQGMGMGGAAPGGDTPNLIDNSETVHISSLALLKMLRHGRAGVPMEVMGLMLGEFVDEYTVRVVDVFAMPQSGTGVSVEAVDPVFQTRMMEMLRQTGRPETVVGWYHSHPGFGCWLSSVDINTQQSFEQLTPRAVAVVVDPIQSVKGKVVIDAFRLIQPQTVVMGQEPRQTTSNLGHLNKPSIQALIHGLNRHYYSIAIDYRKTGLEENMLMNLHKHVWTEALEMSDFHEEGQHNVDRMKQLVLLAEGYEKRIKEETELSKDQLKTRYVGKVDPKKHIEDVSQQLIEDNIVAVSRQMIDKEASVARQSSKEDTNGAVMEVDEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NT92</accession>
    <name>A0A0G4NT92_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Diphthamide biosynthesis protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S001g000262</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DPH4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NT92"/>
    <dbReference type="STRING" id="1429867.A0A0G4NT92"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.660.10:FF:000006">
        <property type="entry name" value="Diphthamide biosynthesis protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044248">
        <property type="entry name" value="DPH3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454:SF46">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454">
        <property type="entry name" value="DPH3 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="J" evidence="13">
        <location>
            <begin position="9"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="DPH-type MB" evidence="14">
        <location>
            <begin position="129"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CRL17302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="201" mass="22136" checksum="BF7F14767224BD96" modified="2015-09-16" version="1">MTRTTHAVDLYEILSLPFTGSSSTVLSKQQIKIAYHKALLKHHPDKAGAVARETGLGGSTNSTSTSTPNPLFAKPDGNSSRQLYTIDQITTAYKTLSDPALRAEYNRSLRLDRLKVAEREKTGDVFHTGLEIVDLEDLACEEAEGGDGDCWYRGCRCGDERGFLVNEEDLEREAEHGEIIIGCRGCSLWLKILFAVEADEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NTH4</accession>
    <name>A0A0G4NTH4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aromatic-ring hydroxylase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S001g000375</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NTH4"/>
    <dbReference type="STRING" id="1429867.A0A0G4NTH4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF6">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="117"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL17415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="406" mass="44821" checksum="0DE6D54C7589D9E1" modified="2015-09-16" version="1">MHVLIVGGGLGGLSLAQNLRKQGISFEIFERDADENARFQGWAIALHSIIDRLSSSVPSDLPDLRESTNHLSPLKLPPQIAMYLPGRTDRIGFQDSPQFPIIRAERGRLRKWLATNIPVRWGCQVTRIEQDEHGVSVHLADGSIAKGDFLVGADGINSVVREHLLQQSSKDLLRVVPLATVVGELTLSGEAFKRQLSLGHSGYMCIRPDLGFIAFVGLHYTLPDGFSGRYYWNFMQTSDVSDPNHWLQTASPQEKRDRVLNAIAGMPAELREIFDQTPVEGIRPESHVWRDLELDSLPVGRVILVGDAAHAMTPFRGEGGYHTLIDTLLLGDIFRDMNTDAKFKDTAAVSEAIASYNKEMLQRGRKAVQDSRNVHGNAGRVGPDGKPLVVEMVPLSDLEIKLGIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NTK8</accession>
    <name>A0A0G4NTK8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alcohol dehydrogenase superfamily, zinc-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S001g000336</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NTK8"/>
    <dbReference type="STRING" id="1429867.A0A0G4NTK8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF1">
        <property type="entry name" value="ENOYL REDUCTASE (ER) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL17376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="120" mass="12917" checksum="D506C0E978789D6E" modified="2015-09-16" version="1">MTVVLLGAHGVFVTAPAAYKTAVSFIGDRIGGIVMCIGLPVAGSMTIGADPCQYIFKNLTIKGTLVGSRSDTAMALDFARRGALRQICEVYPLNRMPEAVEQLRKGEVAGRIVINFNWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NTU3</accession>
    <name>A0A0G4NTU3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S001g000448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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            <end position="253"/>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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            <end position="22"/>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="617" mass="69896" checksum="09A5966FF4EE1FE0" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NUN4</accession>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="82"/>
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            <end position="114"/>
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            <end position="144"/>
        </location>
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            <end position="172"/>
        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL17798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="512" mass="57331" checksum="38BE6F638964EBF9" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NV73</accession>
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        <submittedName>
            <fullName evidence="5">Aldehyde/histidinol dehydrogenase</fullName>
        </submittedName>
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        </lineage>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="ALDH_SaliADH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Gamma-aminobutyraldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD-dependent succinate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF6">
        <property type="entry name" value="CYTOPLASMIC ALDEHYDE DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="4">
        <location>
            <begin position="23"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL17968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="478" mass="50919" checksum="3611CC88A43E9EDD" modified="2015-09-16" version="1">MAQSNKAVTPLIINNESIETEIKFEVHAPATGELSGYCAGVSVDDANRAVDSAQAAFPAWSKTKPHTRRDILLKAAGIMESRKEELIQYQREETGAGRPFSEATFNMGVLFIKEFAGRISTIEGIAPNVSGEGEGAIVYKEPYGVILSIAPWNAPFILGTRAVALPLAAGNTVVLKGSELSPKCFWALGDIFRQAGLPAGCLNVIFHQPSDAPAVTNALIAHQAVRKINFTGSTMVGSIIASTAGKYIKPVLLELGGKASAIVLDDANLDKAAMNCAIGSFMHSGQICMSTERIVVQRSIADEFRQKLAETAEKLFGKDAPALVLVNTAAVAKNKKLVADAVSRGAKLLFGDADASESVNTGMRPIVVDGVTKEMDMYATESFGPTVSLFVVDTEDEAIALANDTEYGLTAALYTNNLFRGLRVAKQIDSGAVHINSLTVHDESVLPHGGWKSSGFGRFGGNSGYDEFLQTKTVTWQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NVA4</accession>
    <name>A0A0G4NVA4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ribophorin II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S001g000945</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NVA4"/>
    <dbReference type="STRING" id="1429867.A0A0G4NVA4"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056790">
        <property type="entry name" value="Ribophorin_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008814">
        <property type="entry name" value="Swp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640">
        <property type="entry name" value="RIBOPHORIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25147">
        <property type="entry name" value="Ribophorin_II_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044187883" evidence="8">
        <location>
            <begin position="24"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Ribophorin II C-terminal" evidence="9">
        <location>
            <begin position="181"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL17985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="289" mass="30624" checksum="FA10ED6AC8B714FC" modified="2015-09-16" version="1">MHLWQATVPFCLLAAAALPGAAATAWGFTDATVAVQAKGAGVNGGFKEKFTASKPLSKPISLFGADTLRVTLTAQEDSSAKRPDQAFLLLKDAQTGLDISYPFSVKDNGKSRVELTQKDLPIQFLSLSGPVDAHIVIGGFGSSVAYDSSVFKLSIDHNPEEAVPTVETERYGKKPEIHHIFKDSASSPPIVITLAFVAMVGAAIPALAGLWLFLGANINHLPTALKSAPLSHAIFLGSLIAFEGIFFLYYTSWNLFQILPAMAVVGAIAFVSGSRALGEVQGRRLAGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NVE8</accession>
    <name>A0A0G4NVE8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S001g000909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NVE8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL17949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="113" mass="12544" checksum="872349D1BCDC7F43" modified="2015-09-16" version="1">MAGKGSNQVRGINLTVWDYLVNIKPQYLNCLWDKGDWTRAHGDNKASVRGAYIMKSMKTSTQPPEYRVLLLHEKEPVLNFTMPGSPNKNGSTDPPTSQEVVDAVAIELSKIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NVT6</accession>
    <name>A0A0G4NVT6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Siderophore transporter, RhtX/FptX family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S002g000037</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NVT6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF187">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="302"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="50"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
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            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL18167.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="563" mass="61362" checksum="3F0253D421E91D81" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NVX1</accession>
    <name>A0A0G4NVX1_PENC3</name>
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            <fullName evidence="5 14">Nascent polypeptide-associated complex subunit beta</fullName>
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        <name evidence="17" type="ORF">PCAMFM013_S002g000083</name>
    </gene>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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        <text evidence="1">Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. EGD1 may act as a transcription factor that exert a negative effect on the expression of several genes that are transcribed by RNA polymerase II.</text>
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        <text evidence="13">Part of the nascent polypeptide-associated complex (NAC), consisting of EGD2 and EGD1. NAC associates with ribosomes via EGD1.</text>
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        <subcellularLocation>
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        <subcellularLocation>
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    </comment>
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        <property type="project" value="UniProtKB-KW"/>
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            <end position="106"/>
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    </evidence>
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</entry>
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        <submittedName>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
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                <person name="Debuchy R."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="103"/>
        </location>
    </feature>
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        <location>
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            <end position="248"/>
        </location>
    </feature>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="818" mass="90073" checksum="B7DBD026E139092F" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWP0</accession>
    <name>A0A0G4NWP0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RNA polymerase II subunit B1 CTD phosphatase RPAP2 homolog</fullName>
            <ecNumber evidence="12">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S002g000393</name>
    </gene>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 17">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the RPAP2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="12"/>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWP0"/>
    <dbReference type="STRING" id="1429867.A0A0G4NWP0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043175">
        <property type="term" value="F:RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039693">
        <property type="entry name" value="Rtr1/RPAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007308">
        <property type="entry name" value="Rtr1/RPAP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038534">
        <property type="entry name" value="Rtr1/RPAP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732:SF0">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04181">
        <property type="entry name" value="RPAP2_Rtr1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_RTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="7 12" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RTR1-type" evidence="14">
        <location>
            <begin position="104"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="271"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CRL18523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="319" mass="35533" checksum="F4B369AF02135E28" modified="2015-09-16" version="1">MAQQGPSHPLKTSLPETYAAIKAQQPPPSYLYPSQEEQDRFLEGRPGATQQHLEVALEHAQQIQTQKDAEDVILNRILELLELPSSPTADPATPSQEDTVKLKYALAPFRPSDYDNLILERNFEDLCGYALCPRKHRKKNGPQGGFQFKYGPKGSGPGGRGRSVDIVSEDRIEKWCSDACAERALWIRVQLSEKPVWERRAGDTRGTTILLLEEARAKRLKAPAATSSVSSVVNDLQSMGLGNRDRSRELALERGDTSLIRPDGRVNVDIRENQRGSQQVAEAPQMRPEDANGGSIEGYVPRERRDVDQDGDIDLLDQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWV4</accession>
    <name>A0A0G4NWV4_PENC3</name>
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        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">PCAMFM013_S002g000482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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    <dbReference type="STRING" id="1429867.A0A0G4NWV4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL18612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="139" mass="15876" checksum="BC49A40867E99CCD" modified="2015-09-16" version="1">MYILEGFQSLDCLPIYTLLPVDDLTPYKGTATLPDIAKATRRLINSLGFVPSHDLTIDCDNERTIGLLTSEDTAFETKLRHVDIHHHWLRQEVQEKRINVRWVATASMVADGLTKLLSKQKHEGFVRMLRMVDIGYLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NX96</accession>
    <name>A0A0G4NX96_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD40/YVTN repeat-like-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S002g000546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4NX96"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051959">
        <property type="entry name" value="PAK1-Kinase_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
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    </dbReference>
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        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675:SF1">
        <property type="entry name" value="P21-ACTIVATED PROTEIN KINASE-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675">
        <property type="entry name" value="PAK1 INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
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    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="WD40 repeat-like"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
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            <begin position="468"/>
            <end position="491"/>
        </location>
    </feature>
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            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL18676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="491" mass="53075" checksum="48A5C8E93ED50488" modified="2015-09-16" version="1">MVKRKRTDAPKEDKTVGTPPKVTKSVAAPSETPDAAFTVQVVTGSYERVLHGFTVEVPASSLKAKAEADSPDIQCMDTFLFEAHGSAIRCLALSPLPKPTDPVDAQKVMLASGSTDERINLYSISAAPPAVNEDYPSVPTFAGNKILENPRNRELGSLLHHTASITSLSFPSRTKLLAAGEDNTISVSKTRDWTVVSTIKAPNPKIQGRPSGDTAPPGAAPSGVNHFAVHPSMKLMLSVGRGEKCMRLWNLVTGRKAGVLNFTREVLQGVKESRWSTGEGRRIAWDSEGEEFAVAFEWGAVVFGIDSIPRCRVLPSPRSKLHQMKYVSLPLKGGEKEDFLAVSTEDGRVIFYSTKELKKAEDDTECSIPHATHVAQVGGKEAGFPGRIKDFEILTLEGQAKELRNDFLVVTGNSDGVVRVWKAAGKEISAAKQEKKDTTQIGKLLATNETGNRITCLAAFVMLPAEDPSTLIDSEDDSEDEVESSSDSDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXH1</accession>
    <name>A0A0G4NXH1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S002g000626</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ELP1/IKA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4NXH1"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056167">
        <property type="entry name" value="A-sol_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056164">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056165">
        <property type="entry name" value="Beta-prop_ELP1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006849">
        <property type="entry name" value="Elp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056169">
        <property type="entry name" value="HB_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056166">
        <property type="entry name" value="TPR_ELP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23925">
        <property type="entry name" value="A-sol_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04762">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23797">
        <property type="entry name" value="Beta-prop_ELP1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23936">
        <property type="entry name" value="HB_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23878">
        <property type="entry name" value="TPR_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017233">
        <property type="entry name" value="IKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="ELP1 first N-terminal beta-propeller" evidence="7">
        <location>
            <begin position="1"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 N-terminal second beta-propeller" evidence="8">
        <location>
            <begin position="407"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 alpha-solenoid" evidence="10">
        <location>
            <begin position="697"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 TPR" evidence="9">
        <location>
            <begin position="918"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 three-helical bundle" evidence="11">
        <location>
            <begin position="1094"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1171"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1273"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1171"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1282"/>
            <end position="1291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL18756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1338" mass="148664" checksum="AEB7E02B87F788B2" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXN6</accession>
    <name>A0A0G4NXN6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S002g000718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NXN6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL18848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="303" mass="34271" checksum="8DD15B6C1C6FF8CF" modified="2015-09-16" version="1">MLPNDPHPSIMSDLPDGHVLHIFSRLEKLQVEARKIFQSLSEHEHGVGNQWIVVLGLSPRNIEILDGESHDILANIPYHFQWEGSIGLIKIDPNSHLIAKSDLTSLIDEKNYLMGVPRNSRIWMGRATYIPDDTATKGKQPGNAFVPSSRRGTSMRLSKFWPTLVIEAGVPKSLPRLRLNAKDWFAISDGQVRIVLLLSITKSEITFEKWQLAPIFAPHPLTREFIDELRQQNPNIPPLIGQPASGQQAYSAQEVSVRSDQVVGDPLVLSFQALHDRTPQQEEGDIVIEREDLEEIRTWMSMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXP0</accession>
    <name>A0A0G4NXP0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">asparagine synthase (glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="2">6.3.5.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S002g000691</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-aspartate + L-glutamine + ATP + H2O = L-asparagine + L-glutamate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-asparagine biosynthesis; L-asparagine from L-aspartate (L-Gln route): step 1/1.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="2"/>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NXP0"/>
    <dbReference type="STRING" id="1429867.A0A0G4NXP0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000031">
        <property type="entry name" value="Asparagine synthase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000050">
        <property type="entry name" value="Asparagine synthetase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050795">
        <property type="entry name" value="Asn_Synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006949">
        <property type="entry name" value="PRK09431.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772">
        <property type="entry name" value="ASPARAGINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772:SF2">
        <property type="entry name" value="ASPARAGINE SYNTHETASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="6 10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="14">
        <location>
            <begin position="2"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="11">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="369"/>
            <end position="370"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="13">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CRL18821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="573" mass="64690" checksum="F151CC7C05BC949B" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXR7</accession>
    <name>A0A0G4NXR7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AMP-dependent synthetase/ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S002g000649</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NXR7"/>
    <dbReference type="STRING" id="1429867.A0A0G4NXR7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF3">
        <property type="entry name" value="SIDEROPHORE SYNTHETASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="285"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL18779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="666" mass="72656" checksum="D45B3957BD0D07C4" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NY32</accession>
    <name>A0A0G4NY32_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome b245, heavy chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S002g000863</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NY32"/>
    <dbReference type="STRING" id="1429867.A0A0G4NY32"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195099" evidence="13">
        <location>
            <begin position="20"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="487"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="516"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="696"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="14">
        <location>
            <begin position="575"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="61"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="61"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CRL18993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="878" mass="97025" checksum="E95B0A011CD687A9" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NY88</accession>
    <name>A0A0G4NY88_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein eS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RPS1</name>
        <name evidence="9" type="ORF">PCAMFM013_S002g000908</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the eukaryotic ribosomal protein eS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL19038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NY88"/>
    <dbReference type="STRING" id="1429867.A0A0G4NY88"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03122">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_eS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018281">
        <property type="entry name" value="Ribosomal_eS1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027500">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11830">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01191">
        <property type="entry name" value="RIBOSOMAL_S3AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="initiator methionine" description="Removed" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="modified residue" description="N-acetylalanine; partial" evidence="6">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL19038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="256" mass="29241" checksum="23FEDDA8254B0CF0" modified="2015-09-16" version="1">MAVGKNKRLSKGKKGIKKRTVDPFTRKDEYSVKAPSTFQTRDVGKTLVNRTSGLKNANDSLKGRIFEVSLADLQNDEDHAFRKVKLRVDEIQGKNCLTNFHGLDFTTDKLRSLVRKWQSLIEANITVKTTDDYLLRLFAIAFTKRRPNQIKKTTYARSSQIRAIRKKMTEIIQREASTCTLSQLTHKLIPEVIGREIEKSTQGIYPLQNVHIRKVKLLKSPKFDLGALLSLHGESATDDKGQKVEREFKETVLENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYG3</accession>
    <name>A0A0G4NYG3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein kinase-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S002g000975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL19105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NYG3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF48">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL19105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="269" mass="30434" checksum="A9929675A7BB451C" modified="2015-09-16" version="1">MWKPVAVPFQNSQPLPTLPTTDEIRACTNVLWQTSSSKIVALNDDIVVKYGGGVDDWEGQALVYLEGHVPEVPAPRLYAMYYDSKQLFLIMQRIPGVPLNSIWPSLTQCEKDEIIAKLQLIFDSMRKAECPWPDFFGGLDGSGVHHYLFYSQHGDDKFLGPFSGEPAFVAGLVGNYRALVGRNNHPDYKARFYEKYLPPVLQGHRPTLTHGDAQQKNIMVVENTSRPGNQVGRSFDVVLVDWENSVQEFIRVWPAEMAMMQLIDKDLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZG5</accession>
    <name>A0A0G4NZG5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S003g000248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZG5"/>
    <dbReference type="STRING" id="1429867.A0A0G4NZG5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL19457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="263" mass="29058" checksum="87D3216BDC299AA5" modified="2015-09-16" version="1">MDRAFSDQERGNIKHPLTFRSIYNAIHCICATQSLHTFSRALVIGLVYQVTHYAIRACLEIAILRHEFLKPFAYACSSVLLCKLHLIWTCATISAHPLPLLSVTENTDQRKWTHLALPSFTYGICQALMYEAQSLIQGSMISTGDEMSISRRAGAETFAVIIMLAFRLTGLLPASIALILTEASLLPSKLETIILSPTKNRGSTIADLRGGCKMPLGIAAFTSSLKGFGVPQLLWLIELHLKKCFVQIAIELLTLPIIIFSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZJ5</accession>
    <name>A0A0G4NZJ5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S003g000287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZJ5"/>
    <dbReference type="STRING" id="1429867.A0A0G4NZJ5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="628"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="707"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="794"/>
            <end position="822"/>
        </location>
    </feature>
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        </location>
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            <end position="83"/>
        </location>
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            <end position="123"/>
        </location>
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            <end position="248"/>
        </location>
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            <begin position="270"/>
            <end position="289"/>
        </location>
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            <end position="371"/>
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            <end position="661"/>
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        <location>
            <begin position="919"/>
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        </location>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL19496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="958" mass="104147" checksum="C6768ED2393E3011" modified="2015-09-16" version="1"> </sequence>
</entry>
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    <accession>A0A0G4P0K8</accession>
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            <shortName evidence="10">U3 snoRNA-associated protein 25</shortName>
        </recommendedName>
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        <name evidence="14" type="ORF">PCAMFM013_S003g000649</name>
    </gene>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
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    </comment>
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        <text evidence="4 10">Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
            <location evidence="2 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
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        <text evidence="3 10">Belongs to the UTP25 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CRL19857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="UTP25_C"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="7 10" id="KW-0698">rRNA processing</keyword>
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            <end position="507"/>
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        <location>
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        <location>
            <begin position="1"/>
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        </source>
    </evidence>
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            <dbReference type="RuleBase" id="RU365070"/>
        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="718" mass="80348" checksum="6DDDF36FC4DEF21D" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0W3</accession>
    <name>A0A0G4P0W3_PENC3</name>
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        <recommendedName>
            <fullName evidence="3">Complex 1 LYR protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="1" type="ORF">PCAMFM013_S003g000716</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL19924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="139" mass="16147" checksum="3438A539AF082D80" modified="2015-09-16" version="1">MNASIQAMKVDQRAMVHAYRHLYRQGLKAIQYSTPGRHMLLKSLRQSYRSSPSEEFNPAKINNTLRFLERATEVAGMEHKILKNLLLARYWEQGHLVRESRVPRSLGLGHVENQLRTSAFDHYNLTLDRLNESLGTCLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P125</accession>
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        <recommendedName>
            <fullName evidence="10">Short-chain dehydrogenase/reductase 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Retinal short-chain dehydrogenase/reductase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S003g000812</name>
    </gene>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
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    </comment>
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        <property type="protein sequence ID" value="CRL20020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4P125"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052650">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000131">
        <property type="entry name" value="Short-chain dehydrogenase/reductase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
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    </evidence>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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    </dbReference>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="775" mass="84441" checksum="ABA3F7555FE478F1" modified="2015-09-16" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
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        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF103473">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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            <end position="89"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038459"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL20315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="541" mass="59140" checksum="C526C2C4629A0306" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3I3</accession>
    <name>A0A0G4P3I3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SNF5/SMARCB1/INI1</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
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                <person name="Malagnac F."/>
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                <person name="Lacoste S."/>
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                <person name="Bensimon A."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF5 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1429867.A0A0G4P3I3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006939">
        <property type="entry name" value="SNF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10019">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04855">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="447"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="488"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="563"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="618"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="753"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="572"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="619"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="655"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="771"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="792"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL20823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="806" mass="88488" checksum="423A71E4245DAC20" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3P6</accession>
    <name>A0A0G4P3P6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S005g000134</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL20970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P3P6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
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    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF281">
        <property type="entry name" value="ASPYRIDONES EFFLUX PROTEIN APDF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="38"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL20970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="427" mass="45419" checksum="6E1001B7790805F5" modified="2015-09-16" version="1">MQTPTDNRDNVTIQESGLGTEEIKAEQPQVTFPEGGLRAWSVVAGAFCISFCTFGYLNAYGVYQNYYSTHQLMGKSASTIAWIGSVQTCLLLGGGIVGGPLFDKYGAKVIWPASIAFIFSVMMTSLGEDYYQFMLAQGILGGLACGIMFSPAMAAVSHYFQAKRGAALGITVTGSSLGGVIFPIALAKMFKNESLGFGWSVRIIGFIMLAMLSLSLATVRPRLPPRKGKILMPSAFKQVAYSLFLAGMFLMIWGVFTPFFYLTEYAIAQGMSANLSSYILSILNASSVFGRLLPGVLADKMGRFNTICFFGSSTGVLLLCWIAVKSNAAIIIFAALYGFFSGAIVSLMSPCIAHLSPTPSCIGTYLGMGMAVISVAGLTGTPITGALIDHYNSYTQAAIFSGVSTLAGAALVFVTKLTKGKHPLTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3U5</accession>
    <name>A0A0G4P3U5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase-like, ATP-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S005g000136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL20972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P3U5"/>
    <dbReference type="STRING" id="1429867.A0A0G4P3U5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="895"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="895"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL20972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1163" mass="132812" checksum="24F02719096B0CEB" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P442</accession>
    <name>A0A0G4P442_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Isocitrate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S005g000238</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-threo-isocitrate = glyoxylate + succinate</text>
            <dbReference type="Rhea" id="RHEA:13245"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="EC" id="4.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Can also use Mn(2+) ion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21074.1"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="BIFUNCTIONAL GLYOXYLATE CYCLE PROTEIN"/>
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    </dbReference>
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    <keyword evidence="8 10 14" id="KW-0456">Lyase</keyword>
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    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
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            <position position="206"/>
        </location>
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        <location>
            <begin position="97"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="13">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="207"/>
            <end position="208"/>
        </location>
        <ligand>
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            <position position="243"/>
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        <ligand>
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        <ligand>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL21074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="538" mass="59750" checksum="B697BFFCE97E6647" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P4Z6</accession>
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        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
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        <name evidence="1" type="ORF">PCAMFM013_S005g000550</name>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
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        <source>
            <dbReference type="EMBL" id="CRL21386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="40" mass="4272" checksum="5200F1E247CFCA82" modified="2015-09-16" version="1">MVGHPGPRTWKNQGTHADTIATQIGMPAHLKATTVIIGTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="5">DNA repair protein RAD50</fullName>
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        <name evidence="17" type="ORF">PCAMFM013_S005g000564</name>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FM 013</strain>
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    </reference>
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            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
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            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
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        <cofactor evidence="1">
            <name>Zn(2+)</name>
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        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SMC family. RAD50 subfamily.</text>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0016887">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:telomere maintenance via recombination"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="DNA repair protein RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001195">
        <property type="entry name" value="DNA repair protein rad50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004584">
        <property type="entry name" value="Rad50_eukaryotes"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00606">
        <property type="entry name" value="rad50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867">
        <property type="entry name" value="RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13558">
        <property type="entry name" value="SbcC_Walker_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Rad50/SbcC-type AAA" evidence="16">
        <location>
            <begin position="5"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="203"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="304"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="392"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="579"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="709"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="792"/>
            <end position="1048"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CRL21400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1300" mass="149420" checksum="EDDBD10A18EA5B76" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5D3</accession>
    <name>A0A0G4P5D3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S006g000058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P5D3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL21518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="381" mass="43656" checksum="ADFFDA5A74A5B173" modified="2015-09-16" version="1">MSWYDRWIFQQLQNLPHSLVQLRVGKSKIQETHSLNTLFESIEDYCARETEGVSIDEITTHLRETGVFDDANSLQGHQTLLVFAALGWCSMLYQAAFNVCSAQELAIHQDSDQPQSGLVFDMYKVSAELSDRPISVLLKAFGNLLPARSSNSGYLASETGSMASFWRPLHPEETNAYLLHVLLRVQIRWVDTLALHLDYDKSTRTLSLFRYPSFCLEMPLSRGLIFSFSSIESFPEDPRANEEEISQFLQEVLLSYRLLFAQSAPSRRLFRQIYTMSDLGNHPADSLLFQLCTQKRIGQKLAMLPADKPLYFAARDFPVLYDRIELMANDLKDARPSSILSLMRDRRDTLKYWTFWLVAIFGGISIFLSLVQVILQGFSMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5E8</accession>
    <name>A0A0G4P5E8_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Glutathione S-transferase omega-like 2</fullName>
            <ecNumber evidence="3">1.8.5.1</ecNumber>
            <ecNumber evidence="4">2.5.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glutathione-dependent dehydroascorbate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S006g000039</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Active as '1-Cys' thiol transferase against beta-hydroxyethyl disulfide (HED), as dehydroascorbate reductase and as dimethylarsinic acid reductase, while not active against the standard GST substrate 1-chloro-2,4-dinitrobenzene (CDNB). May be involved in cell wall organization and biogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate</text>
            <dbReference type="Rhea" id="RHEA:24424"/>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58539"/>
            <dbReference type="EC" id="1.8.5.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GST superfamily. Omega family.</text>
    </comment>
    <dbReference type="EC" id="1.8.5.1" evidence="3"/>
    <dbReference type="EC" id="2.5.1.18" evidence="4"/>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P5E8"/>
    <dbReference type="STRING" id="1429867.A0A0G4P5E8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045174">
        <property type="term" value="F:glutathione dehydrogenase (ascorbate) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03190">
        <property type="entry name" value="GST_C_Omega_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000162">
        <property type="entry name" value="Glutathione S-transferase Gst3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000038">
        <property type="entry name" value="Glutathione S-transferase omega-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047047">
        <property type="entry name" value="GST_Omega-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="GLUTATHIONYL-HYDROQUINONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01206">
        <property type="entry name" value="Xi.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01148">
        <property type="entry name" value="Xi_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST C-terminal" evidence="14">
        <location>
            <begin position="256"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00070045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CRL21499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="422" mass="48673" checksum="0CEC105A4184F703" modified="2015-09-16" version="1">MGFAKTIQIALSKLIDLPISKSDSAFGHARERHDPRKTDIFAFPIYTTPLKHLSRPILCTGPLRAAYQSFVFPAVPIIYSRNMATGNAMSITDWVKPGDKSGEFKRQQSVFRNWISREAGAQFPPEKGRYHLYVSYACPWAHRTLIARKLKGLEDFISFSSVHWHLGAQGWRFATPDEKLSGENTIPDPLHPEFTHIRQVYFSNDPEYTGRFTVPVLFDKKTKLIVSNESSEIIRMLYHEFDDILPEQYKKIDLFPEALQAEIDASNEWIYNDINNGVYKSGFATTQEAYEKAVTTLFSSLDKVEAHLVKQQAASKPYFFGDEITEADIRLYTTIVRFDPVYVQHFKCNLRDIRSGFPAIHRWVRRLYWEVPAFRDTTDFEHIKFHYTKSHTQINQFAITPLGPVPDILPRDEEVKAVQAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5T7</accession>
    <name>A0A0G4P5T7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S006g000197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P5T7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL21657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="56" mass="6191" checksum="6D496E2012FD3160" modified="2015-09-16" version="1">MSTEFSVRCNGPCNKVKPCKPYPVSKMYCHRCAVRKGLLVDESVSQPATNTTVSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6F6</accession>
    <name>A0A0G4P6F6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S006g000442</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Lacoste S."/>
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                <person name="Bensimon A."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
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        <text evidence="1">Required for efficient assembly and nuclear export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the 66S pre-ribosomal particle.</text>
    </comment>
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        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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    </gene>
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            <taxon>Aspergillaceae</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="7">Sucrose/H+ symporter, plant</fullName>
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        <lineage>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Conseiller E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF10">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
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    </dbReference>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="113"/>
        </location>
    </feature>
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        <location>
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            <end position="144"/>
        </location>
    </feature>
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            <end position="171"/>
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            <end position="236"/>
        </location>
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    </feature>
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    </feature>
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        <location>
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            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
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        <location>
            <begin position="58"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL21939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="535" mass="57906" checksum="D68DFFE36A469AFC" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6Y5</accession>
    <name>A0A0G4P6Y5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S007g000047</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
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                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793140">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4P6Y5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="prtT"/>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
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    </dbReference>
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        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
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    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
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            <begin position="12"/>
            <end position="41"/>
        </location>
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        </location>
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        <location>
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            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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            <dbReference type="ARBA" id="ARBA00023163"/>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL22066.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="599" mass="65959" checksum="3C184A375F557268" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P713</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
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            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        </subcellularLocation>
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        </location>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="CRL22039.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="278" mass="30945" checksum="5EFE74BE591A836F" modified="2015-09-16" version="1">MAFQPTPMDISVIITNAALAKPGDSEPRFLTERRITPTWTVMQVKAKLETMTGIPPGSQRLRVKVPGRPDQWADGDDRLIGDWGLVKGSEIEVNDSRPQTMRANFTDLSSVEKYVLPTETYEARSDSVLAWKKNQKLGRFDPNALSPEDALRHQVEKDQNEVQTRGITIAKRAIILPSSPPHIRRGTIRFVGPVPTIPITGPGRELQQDAELPADLQPIWVGIELDEPMGKNDGSVGGQRYFECLSNRGVFVKPEKVEVGEFPPLGLDDDLDDLMEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7B3</accession>
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        <submittedName>
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        </submittedName>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        </location>
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        <location>
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        </location>
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            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL22233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="321" mass="36093" checksum="7EFB65560F498423" modified="2015-09-16" version="1">MSLIGQVFNKILNKSIPVYIANSGNGYIRYPALIDQAVKEAALAKVKAPFESGKLFKDDDMRQMEQLTITNMSHSSLGDSNAHYSVQGETSAGSKVKGNHAQEDESKQTFEHRIKPELSVDRDGELKLVQLQIKHQGRCDYMKSLAYDYSGILEMLERLHSLHIQVSQGANDTLTHLVALLRADQGLERKPRNQSVLGRIVVLRRTATIIKAEEEGRQGKERNRCITLVEFLRCCHKVLSRPLRVRTSSDSTTGEIPIPKGKHWSTLLERWVDCPTQQQGILQLRTSLPPGRKNAPRLFLPRIMLDALSERFKGPMGGDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P8T2</accession>
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        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
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    </organism>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
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                <person name="Lacoste S."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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            <end position="387"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="774"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        </location>
    </feature>
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        <location>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL22712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="815" mass="91658" checksum="A51F6691B574418C" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P977</accession>
    <name>A0A0G4P977_PENC3</name>
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            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">PCAMFM013_S008g000295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4P977"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046623">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395:SF1">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="545"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="611"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="660"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6536" evidence="2">
        <location>
            <begin position="82"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL22866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="764" mass="83743" checksum="F34A0115314FDAA4" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P9H8</accession>
    <name>A0A0G4P9H8_PENC3</name>
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        <submittedName>
            <fullName evidence="5">Nucleotide-binding, alpha-beta plait</fullName>
        </submittedName>
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        <name evidence="5" type="ORF">PCAMFM013_S008g000363</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793141">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF51">
        <property type="entry name" value="SERINE-ARGININE PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RNA-binding domain, RBD"/>
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    </dbReference>
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        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="7"/>
            <end position="79"/>
        </location>
    </feature>
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        <location>
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            <end position="168"/>
        </location>
    </feature>
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        <location>
            <begin position="182"/>
            <end position="303"/>
        </location>
    </feature>
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        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL22934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="303" mass="35572" checksum="19C11088897B0A6E" modified="2015-09-16" version="1">MTEVSSTRLYLGNLPRNVTKSDIEEHFSSHGSGKITEIKLMSGFGFIEYDDQLDARDIVPAFHGSDFKGERLTVQFARGPRRKEAFPGPPDRNALPRPRRTMFRMQISGLPETSWQDLKDFARQSGLDVVYSETGREQGRGFVEFETANDLKTAVEKLDQREFKGSVVSCVADIQNFEERPVRDPYRSRSPPRRPYPATMEEYDRRIPPPRGYSPREHYRERSPIPIRRDPYYERDAYARRTPPRPRMEDYPPPRRPYEDPYEARPPPPPRHYDDPYLAARGYGRPRSPPRGEYVPYDRPRYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P9I2</accession>
    <name>A0A0G4P9I2_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S008g000407</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P9I2"/>
    <dbReference type="STRING" id="1429867.A0A0G4P9I2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13993">
        <property type="entry name" value="STKc_Pat1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000549">
        <property type="entry name" value="Protein serine/threonine kinase (Ran1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF32">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="32"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000304"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL22978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="413" mass="46093" checksum="B3427B5AAF4A5A3B" modified="2015-09-16" version="1">MYPAMLPTPPPSPAPRRYAPEDRLGLVLANRLELTRVLGVGAYGVVYTAVDIHTNEVYAVKVLCKDGLDARQLKFQQREIRLHHMASQHPNVVPLVRIMDSLDCTYVVMEYCPEGDLFSNITDKGNFVGNDFLAKSVFLQILDAVQFCHSLGIYHRDLKPENVLVTENGMTVKLADFGLATTDYYTTDFGCGSTFYMSPECQQSNARPLSCYMSAANDVWSLGVILVNLTCGRNPWKRASVEDSTFQAYLKDPFFLKTILPLSSEMVSILSRVFELDPMKRISIPELRQLILECPRFTENPMVQTPWVPEQIDYIPQPQMPMFMGPMEPLYAQTSGSSLDSAQYSAFSQSAASDGSAITEDYSDFDTMSPAVSEQVPDCKAVFPSVCAEPFFPADPFAYGLMHPNLQGMEIPV</sequence>
</entry>
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    <accession>A0A0G4P9R0</accession>
    <name>A0A0G4P9R0_PENC3</name>
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        <submittedName>
            <fullName evidence="8">Str. FM013</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">PCAMFM013_S008g000476</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="prtT"/>
    </dbReference>
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        <property type="entry name" value="XnlR_reg_dom"/>
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    </dbReference>
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            <end position="61"/>
        </location>
    </feature>
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        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL23047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="525" mass="59978" checksum="2927529B16AF2E87" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PA67</accession>
    <name>A0A0G4PA67_PENC3</name>
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        </submittedName>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
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                <person name="Lacoste S."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL23202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="67" mass="7397" checksum="C5E8016FA4FF6380" modified="2015-09-16" version="1">MESHAPLRQDMGDKSRDAGVPRSLLGGRKDYRQAMGNQYPVPTKCGHGQTEVPKRNQTEPKAMADDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAR1</accession>
    <name>A0A0G4PAR1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase superfamily, zinc-containing</fullName>
        </submittedName>
    </protein>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
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    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="21"/>
            <end position="378"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL23359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="381" mass="40359" checksum="4F854B315A1E3502" modified="2015-09-16" version="1">MAPVNQAAWIPAKKVLPFKVGDAPYTRPSAGQVVIKNTAVAINPFDWVLQYIGPALAGYIKYPFIFGTDVAGEVIEVGPDVERFRIGDRVCGSAAAIAKEVNRPAEGAFQLYTVMRQNMLTPVPPNITDEQACVLGLGLGTAAYGLFHPDYLGLDMPQIPAPTKVVGKSGLPRTVIITGGASSVGSNAVQLAVAAGYQVLSTSSPKNFDYVKGLGATHVFDYKSKTLVKDLLGALKGHELVGAYTIGDGAVQTCTAVMKRRDPKLTRKFIAVAGAIIPAEKLTTFVGKGTFLMGMMGGMIKSTGTRIRTGVEAKFILVDGLADPDSVVSRIYTSFLPQALEQGQFVPAPPPYVVGKGLDKIQEALHLQRKGVSGKKLVVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PB99</accession>
    <name>A0A0G4PB99_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S009g000484</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PB99"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF287">
        <property type="entry name" value="MFS MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="243"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="247"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL23544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="441" mass="48216" checksum="ADE3C02352AEFA2D" modified="2015-09-16" version="1">MEPKEYPPSFTSRSTSFIPFDQQSDSRIILDDEKLPPVDRGVQAWLFLMASAMLESLVWGYAFAFGIFQDYYSTHEPFQGSGNIAIIGTCAMGIAYLIAPLVIILMILVPKIARWVSTIGVVIMCLSLALSSFSTNVMHLILSQGLGFGIGGCFAYTPTILFMSEWFDKRKGLAFGIVWGGSGVSGIVFPLAIQWLLNQYGIEATLQISSVTLFILAVPFLYFHRPRLHTTEIAYHRLNFRFLYNKVFIIYQLGNTLEAIGFFLPTIYLPSYARSLGASDYMASLTVVLVNLFTVFGCVIMGFLSDRYHITTCILMSTVGTVIAVFFIWGFAATIPPLYVFCIAYGLLAGGFSSTWAGVSHEVQKANPSADATVIFPFMETGRGIGNVASGPLSEALLKADNWRGHALGAYGSGYGTLVVCTGATALIGGFSVVARQLKWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBU8</accession>
    <name>A0A0G4PBU8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Taxilin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S010g000239</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the taxilin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PBU8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PBU8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026183">
        <property type="entry name" value="Taxilin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16127:SF13">
        <property type="entry name" value="GH01188P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16127">
        <property type="entry name" value="TAXILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09728">
        <property type="entry name" value="Taxilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="358"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="281"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="363"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL23801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="434" mass="49948" checksum="5715BB7FD6B3258E" modified="2015-09-16" version="1">MSSTSMAKKNKAKKAADPNETSKLLAAKISQLEQDAAGEKDQEAEIEREVKKATRDLNQLLSNIESPMTKLETVHKKYTELLADMKKLDRDYSKSKKRADQLQKDQDKGKSDLNKTVTMKDKLEKLCRELTKENKKVKDENKKLEDTEKKARLIVNERLDSLLYDIQDVMAAKGNPRSEKVDVDLDDALRAKLKTISEQFDTRDLHYRGLLRGKDSEIQSLASKFEEQRRAGEVEANRSRALTSQVSTFSHTEAELRSQLNIYVEKFKQVEDTLNNSNDLFLTFRKEMEEMSKKTKRLEKENHTLNRKHEQTNRNILEMAEERTRNHEELERWRRKCHHLEALCRRMQAQGRGEGLALAEGDDHLEGDDEGTESEYDDDYEDDEEDISDEEDLEPPPTRVEQPSEKPVFGPTPPPNLLEARANGNSAGVNGLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBV2</accession>
    <name>A0A0G4PBV2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S010g000203</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cytochrome c oxidase subunit which plays a role in assembly of respiratory supercomplexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Associates with the respiratory chain complex III/complex IV supercomplex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RCF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PBV2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PBV2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050355">
        <property type="entry name" value="RCF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297:SF3">
        <property type="entry name" value="HIG1 DOMAIN FAMILY MEMBER 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297">
        <property type="entry name" value="HYPOXIA-INDUCBILE GENE 1 HIG1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="11">
        <location>
            <begin position="7"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="133"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL23765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="179" mass="20656" checksum="3D850F0432F77621" modified="2015-09-16" version="1">MNREPVPSSFDEGNPQFTEETGVQKFTRRLREEPLVPLGCAATCYALYRAYRSMKSGDSVEMNRMFRARIYAQAFTLVALVAGGMYFKTERQQRREFDQAVELRKKQEKRDAWLRELEIRDKEDREWRERHASIEAAAKEVGNKPAPPKEPEAARSSIEPADEKSIGIMDAVRALISRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PC35</accession>
    <name>A0A0G4PC35_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Toll-like receptor 7, leucine rich repeat-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S010g000311</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A0G4PC35"/>
    <dbReference type="STRING" id="1429867.A0A0G4PC35"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="172"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL23873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1037" mass="113349" checksum="419DC5A3CEA1DC7A" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PC42</accession>
    <name>A0A0G4PC42_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial</fullName>
            <ecNumber evidence="10">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Succinyl-CoA synthetase beta chain</fullName>
            <shortName evidence="10">SCS-beta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S010g000321</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 12">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="10"/>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PC42"/>
    <dbReference type="STRING" id="1429867.A0A0G4PC42"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000001">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_ligase-like_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001913">
        <property type="entry name" value="PRK00696.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF1">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="13">
        <location>
            <begin position="41"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="85"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="360"/>
            <end position="362"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CRL23883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="443" mass="47598" checksum="093FF16694ADCDCB" modified="2015-09-16" version="1">MFKLARGRPVAAAFKAATQPSIQSRLAVQKRNLSIHEYLSARLLKSYGVGVPKGEVANNAEEAEAIAKSIGGGDLVIKAQVLAGGRGKGQFDNGLKGGVRVIYSPTEAKMFAGQMIGHKLVTKQTGAGGRICNSVYICERKFARREFYLAVLLDRTTRGPVIVSSSQGGMDIEAVAKESPDAIMTTPIDIHVGVTDEIARTIATDLGFSEQCIEEAKSTIQNLYKCFMERDATQLEINPLSETSDHQVLAMDAKLGFDDNAEFRQKEAFSWRDVSQEDADEVKAAEHGLNFIKLDGDIGCLVNGAGLAMATMDIIKLNGGSPANFLDVGGGATPAAIKSAFELITSDPKVSAVFVNIFGGIVRCDAIAQGLINVVQEMNLRTPIIARLQGTNMEQAHKLINESGLKIFSIEDLQNAAEKSVQFSKVVKMAREIDVGVEFTLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PE60</accession>
    <name>A0A0G4PE60_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S012g000176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PE60"/>
    <dbReference type="STRING" id="1429867.A0A0G4PE60"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="41"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL24566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="317" mass="35974" checksum="5DAD9EA9AF9034BD" modified="2015-09-16" version="1">MQPIFKIDWDKGDKDGLVSVGSHNLYLSVSGPDRKPGKPIVVLMQGLGSTIDEWVIVRKLVVPFARWLNYDRSGMGRSEGPNQTPPSISAASVAAELDTLLRNAGIEPPFIIVAHSWGGYTSREFLELRPNDVVGMVFVDCNTERFFDSGAWGWDIFSPVLGDQDFFETTGLTTSHALSEEEWKAVKDEQADPRHQATEAAELQAVPDDRRALAHKNQLEKLLLKDYPVSVIIADTPKDFQKMYDFGVAAGNGTEQERALFRKCLDRWREMNEDWQRDLLRLSRLSRSVRLQCSHNVQLLQPQSIVQEIQWTMDRCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PEQ6</accession>
    <name>A0A0G4PEQ6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="2">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S012g000359</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="2"/>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PEQ6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PEQ6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="4">
        <location>
            <begin position="22"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="4">
        <location>
            <begin position="104"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL24749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="247" mass="26721" checksum="D4B21E2910D86C56" modified="2015-09-16" version="1">MTSIESMKTQTIKTRLFINGKFVESSDNRMFDLISPTRNEKCVKVYEASEDDTNAAVAAFPAWSALSSSQRESYFKKLASLILQSHEELAQLEAMSMGSGNNKSQYPGYVNMTVRQPFGVVAPIIPWNVPILFLAGKPAPALMAGNIVVIKSSEKAPLTSAKIATIVEKASFPPGVIGIISRHGSERIGRLIQSAAAASNMKNVILELDGKSPAIIFADADIAKAVEETKDSIQWNIGQVCMANSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PEU6</accession>
    <name>A0A0G4PEU6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S013g000082</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL24839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PEU6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL24839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="82" mass="9541" checksum="9005DCDB131D14FA" modified="2015-09-16" version="1">MDQKRNVPSGLYEGSSLKTSLGAAFPHRPWNLLYNAFHTQNDLAPRYPDDISLLMKTIYGLKQSPRERYTFKTFKQWSMASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PFG0</accession>
    <name>A0A0G4PFG0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NCT transcriptional regulatory complex subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Negative cofactor 2 B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S013g000248</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Part of the NCT transcriptional regulatory complex that acts as a key regulator of ergosterol biosynthesis and the azole exporter cdr1B. The NCT complex binds the promoters of genes linked to azole susceptibility, and especially represses the expression of cdr1B transporter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Forms the NCT transcriptional regulatory complex with nctA and mot1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL25005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PFG0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PFG0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22905">
        <property type="entry name" value="HFD_Dr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000019">
        <property type="entry name" value="Negative cofactor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042225">
        <property type="entry name" value="Ncb2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138:SF1">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="9">
        <location>
            <begin position="13"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00053814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00065193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00079659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL25005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="142" mass="16121" checksum="530D44200BDDEE3D" modified="2015-09-16" version="1">MSDREFNSNDDLSLPKATVQKIITEILPPSSGQTFSKDARDLLMECCVEFITLISSEANDISEKEAKKTIACEHVEKALRDLGFSDYIADVLAVAEEHKQQLKSREKKQSKMEQSGLTEEELLRQQQELFRSATDKYHAVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PFQ7</accession>
    <name>A0A0G4PFQ7_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar calcium ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S014g000029</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PFQ7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PFQ7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000026">
        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000027">
        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF14">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 10" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="12">
        <location>
            <begin position="103"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="12">
        <location>
            <begin position="309"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL25133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="463" mass="51233" checksum="DE07F9F41457B00A" modified="2015-09-16" version="1">MGSIRSTHSQNAELRLRGSDQSKTVQEKRSQNSILPTNSTTSKRAWALFRVDTAGESGRSGIHPWHLLKVCFRSVCTLSMVVNILWPFVPAAIAIYFARPDLHVWIFSLNYIAMVPSANVLGFAGGELAKKLPKMIGIVVETTLGAVVEIVLFMVLLYNHGRTEHSDLIPVIQAAILGSIMANLLLCLGMCFFVGGIKRHEQTFHEAISEVGTGLLLVAGFGLLIPSAFYSALRGSVNDHFTLAQLNEYALTISRATSVILLVAFLTYLFFNLHSHNSIFDEILEKDEHHDEDRHEEAARAKLTMIECFVVIAISLACVCMSAVFLVQEIEYIVERGVSDNFLGLILVPLVEKAAEHLTAIDEAWDNQINFALFHCLAPSIQTALLNAPLTVIVGWGMDKDMSLNFEIFMVVLLVLSILVVGNFLRDGKSNYLEGALCVLVYFIIAVCTWYYPPVHMASTNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PFS7</accession>
    <name>A0A0G4PFS7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S014g000069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PFS7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL25173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="65" mass="7324" checksum="EF7E4B1A44A44F8B" modified="2015-09-16" version="1">MNVQSISWLHGKMQCEVKSKVARPQPSSITPDPGFVVRCYSREGSGWRLAHSKSLKSHEKSRVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGE6</accession>
    <name>A0A0G4PGE6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S014g000263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PGE6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL25367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="50" mass="5697" checksum="3A12566045A8C503" modified="2015-09-16" version="1">MHRSPSKLKIRLETITQPKKEYPEQERDINNLGTTLATPPPPEPTTQKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGE9</accession>
    <name>A0A0G4PGE9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S014g000292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PGE9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195663" evidence="1">
        <location>
            <begin position="18"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL25396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="56" mass="5783" checksum="E90834253D20D573" modified="2015-09-16" version="1">MRFSILALATVIGLAFASPIQADAGSALSSRSNNCFTLCKIDGGSDQGCLEKCKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGP9</accession>
    <name>A0A0G4PGP9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metal-dependent phosphohydrolase, HD domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S014g000306</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PGP9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PGP9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33594:SF1">
        <property type="entry name" value="HD_PDEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33594">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03035)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195527" evidence="2">
        <location>
            <begin position="18"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="HD/PDEase" evidence="3">
        <location>
            <begin position="239"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL25410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="447" mass="47154" checksum="C0FD2903B7A0EE71" modified="2015-09-16" version="1">MKFSILALSALLAFVAAADTTTASPSTITTTPEIQCAKSCEATDICCTAKCYHVPCPSDNQVNDTNNCVSACPQGTGSPADIQKYAECEQSCYNSHFWGGNGSGTTATHSSTTSTGTGSTATQTSSDSSSTDSKSSGNNDSNDNNDNDESSSSGTATSSSGFSQQTANAAANVKLGASAAGLFGLVVAAFTLSYHRAEKSPNLPTTGLKAPTMDDTSEEFQALYSEMSAFVTDCMSGHDPSHNPAHVHRVGALANKILEAERALHPTTQYNGAVVKLAALLHDIGDRKYLSKMSAAPGSEELDPTTMVQHALLARGATPELASRVQTIVSHVSYTTECKDPALIQRMVDEDGFVELGVVQDADRLDAIGAVGIGRCFTFLGAVGKKYCVDGKWEMDNSIEHFGDKLVKLEGMMKTATGREMARVRTERLNIFAGWWQEEMSLASGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGT9</accession>
    <name>A0A0G4PGT9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyclin-like F-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S015g000026</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793148">
        <property type="protein sequence ID" value="CRL25440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PGT9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL25440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="144" mass="16246" checksum="23355449C6654798" modified="2015-09-16" version="1">MLSTLPPELLRIICKFLDKDNLLKLCLLCRCTSSISSEGLYRCLTSERMPPLHRAIRCARLDVAARLLDKYQADINSDYASKTPLLLAIELRYPEAIEFILRYESVDINCCDFGGNGILSLAVTNGSLAIVERLLRFDSVNINY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGW8</accession>
    <name>A0A0G4PGW8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phytanoyl-CoA dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S015g000061</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793148">
        <property type="protein sequence ID" value="CRL25475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PGW8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PGW8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF19">
        <property type="entry name" value="MULTIFUNCTIONAL DIOXYGENASE AUSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL25475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="324" mass="36168" checksum="A0A688B2AD6A2C4A" modified="2015-09-16" version="1">MWRIPTDVPQTAIPNGLQLAEVPAGSPLDEVFKHWKESGAVILKGMLTPEEADRVTSELEERLDSVQRGTLIPHEDLAAFHGPKTKRAGDLINHSATFRERVVENNFIHDICRRCFSEGGHNGDYWLSTASTLHAAGPQPGQVLHRDLTSYPPYAMLGPDGTEAKISFLFAFSDFKDENGATRIIPGSNKWPFHQRGNMSQTIPAEMKKGDVLLIGGKVIHGMGENKTQEERKCIQLTVVPSFLTPSEAQPLIVTLDTAKTMSKRAQRFLGFRSQYPRGSPGLWTKDYIDLALHVGLDNLRGAMEDLQDVMNQPKQWDTIDYDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PH82</accession>
    <name>A0A0G4PH82_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S015g000264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL25678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="204" mass="23376" checksum="0ECB3C4F0C3EACFD" modified="2015-09-16" version="1">MDEVLLDFFSDFVLTTRTRCGQAAVLAPDCDLFDLIQRIYSLHCDRDGELNLSPLSISDAVHIWQDLDDWDPAGTELINEDDNLYESYKFALFIWTYIIVHPAEVGGEKVQDALHYAMSNISEVEAPDLVPLVIIPLFFSGLAAIQHVDRDLVNEHYERVESYTEHGSVTRSRHIVQSSWEKHDNGMEQSWDWRRWSNASSTGS</sequence>
</entry>
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    <accession>A0A0G4PI06</accession>
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        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S016g000245</name>
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    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CRL25964.1"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PI06"/>
    <dbReference type="STRING" id="1429867.A0A0G4PI06"/>
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        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL25964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="136" mass="15663" checksum="3F50C31061D886B9" modified="2015-09-16" version="1">MESTLKPKHYVRRPRRGGKKLLISLGKTKWSKGETLQLQVYKGRRETFETSDPETLRSLHALGLIHNSRRKYAEAEAVFREGWKGRGETLGANHEDTLESLSRLRDIIRDGSPFTKTAPKPKPKPRLRESLSPFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PIN4</accession>
    <name>A0A0G4PIN4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">NADPH:adrenodoxin oxidoreductase, mitochondrial</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PCAMFM013_S017g000268</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>2 reduced [adrenodoxin] + NADP(+) + H(+) = 2 oxidized [adrenodoxin] + NADPH</text>
            <dbReference type="Rhea" id="RHEA:42312"/>
            <dbReference type="Rhea" id="RHEA-COMP:9998"/>
            <dbReference type="Rhea" id="RHEA-COMP:9999"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.18.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the ferredoxin--NADP reductase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.6" evidence="4 15"/>
    <dbReference type="EMBL" id="HG793150">
        <property type="protein sequence ID" value="CRL26285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PIN4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PIN4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000036">
        <property type="entry name" value="NADPH:adrenodoxin oxidoreductase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055275">
        <property type="entry name" value="Ferredox_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021163">
        <property type="entry name" value="Ferredox_Rdtase_adrenod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000362">
        <property type="entry name" value="FNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 15 16" id="KW-0274">FAD</keyword>
    <keyword evidence="7 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 15 17" id="KW-0521">NADP</keyword>
    <keyword evidence="12 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="19">
        <location>
            <begin position="48"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="194"/>
            <end position="197"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="238"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="440"/>
            <end position="442"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR000362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CRL26285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="533" mass="58716" checksum="B02C5FEDDA6B9CD8" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PIX6</accession>
    <name>A0A0G4PIX6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S017g000144</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL43 family.</text>
    </comment>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Thioredoxin-like_sf"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="L51_S25_CI-B8"/>
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    </dbReference>
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        <location>
            <begin position="37"/>
            <end position="110"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL26161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="142" mass="16000" checksum="B6D6C4711789D2F9" modified="2015-09-16" version="1">MRGRTMPLRGIRTSTAARNGAGAFILQCKRLDFHYCNWAGSSKGMVAFLEKTLPAFARENPQIEIRVSPRPQKHPLIKGLYINGREKPVCVRNLEPHEILKKANLLKEASGEKLKRVKKPVTSLNESVRGIWSPYHGDLRGV</sequence>
</entry>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0009267">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0862">Zinc</keyword>
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        <location>
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            <end position="93"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="110"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL26715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="266" mass="30395" checksum="B5A3DDC9B521601B" modified="2015-09-16" version="1">MVRSMRIRNFMRSRTAKINPWKLIKTFSKMTSLSMASRNEFQIPRPRKKARRSCLYCQKAHKTCGNERPCGQCVKRNMPSQCVDGIRKPPKYLNESTKKSRKTGLYHGVTSPQQTQCQHEDIPNTTSYGNEIIEQEANDKGHIKYHRSDSFEEVFDEVIDSNFFYTERSSFKFGNEPSEGTILKGNDNFVTFFSDAEFATWSERSSSVSEDSELGTSYQAPEDGLGASLVELQRHARDEPYSGFAISSGWSSTFFPHEVEEEPNGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJW6</accession>
    <name>A0A0G4PJW6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ankyrin repeat-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S019g000134</name>
    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24133:SF40">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140860">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="128"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="165"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="382"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL26717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="696" mass="76954" checksum="210B9EF193440A80" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJX6</accession>
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    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S019g000076</name>
    </gene>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793152">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJX6"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL26659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="50" mass="5927" checksum="38354B32D4E274B0" modified="2015-09-16" version="1">MQSSFNGSYRDSQDLHWTSANIQRRWDTDPYSITDGKRKEQVQSKKTSFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PK13</accession>
    <name>A0A0G4PK13_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arylsulfatase</fullName>
            <shortName evidence="5">AS</shortName>
            <ecNumber evidence="5">3.1.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aryl-sulfate sulphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S019g000182</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an aryl sulfate + H2O = a phenol + sulfate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17261"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:33853"/>
            <dbReference type="ChEBI" id="CHEBI:140317"/>
            <dbReference type="EC" id="3.1.6.1"/>
        </reaction>
    </comment>
    <comment type="PTM">
        <text evidence="6">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="5"/>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PK13"/>
    <dbReference type="STRING" id="1429867.A0A0G4PK13"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005539">
        <property type="term" value="F:glycosaminoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008449">
        <property type="term" value="F:N-acetylglucosamine-6-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018958">
        <property type="term" value="P:phenol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16147">
        <property type="entry name" value="G6S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012083">
        <property type="entry name" value="Arylsulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108:SF8">
        <property type="entry name" value="SD21168P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000972">
        <property type="entry name" value="Arylsulf_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013062594" description="Arylsulfatase" evidence="7">
        <location>
            <begin position="16"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="18"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="6">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000972-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL26765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="572" mass="64406" checksum="44FD5DF59C6D3F48" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKX4</accession>
    <name>A0A0G4PKX4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S020g000229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793153">
        <property type="protein sequence ID" value="CRL27070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKX4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PKX4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL27070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="376" mass="43288" checksum="910384C98F854B63" modified="2015-09-16" version="1">MDKSIEIDPVYYDHGRDDYVDSDFASETTSLSSSVYRGVFENGRRYQTVREGASWFPSDEQQFESLEAGHLLCILLDADTDNPLYQAPLKDPKVYTYTQRQKNHGKPPLTKCKQILDIGTGRGNWAIDVADIFPNATVRGVDLFPPPGDWLPPNCIMEVDDVLQEWTWRQPFDLIHMRQLIGAFTPVEWDGLFAQCYKNLTPGGWIEQIEGDPRIHCSDSSMAPDSSMVQFTEAVFRAGQEWNHPLDTLDTMRAAMEKAGFVDIHEKSYRWPVGPWARDPTLKEVGRLHYHQWTAGMEGWGMYLLTKFGVPVPWTKEEVLVLLAKVRKELQDPHIHMWQYARRVWGRKPTEEEEEEKEKEGGKVKSEEVDAKYSAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PM76</accession>
    <name>A0A0G4PM76_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S022g000200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793155">
        <property type="protein sequence ID" value="CRL27520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PM76"/>
    <dbReference type="STRING" id="1429867.A0A0G4PM76"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039327">
        <property type="entry name" value="CON7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167:SF3">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL27520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="304" mass="34620" checksum="6FFA7F04D5601E10" modified="2015-09-16" version="1">MCNSNSDYEKTTRVADLGTKLSVKLFSFYRQVKNANESIQLLSNEVALVSAILRELGDNLKDENASKICSDEAFRTLTRVLDQCRDVLGQIERVTDNFNQPGKNRFQQVTEKFRLVLVDPALEPLKFNLESLKSTMLLLLNVIMYAVQIRRYVRLFLMFTIRKNDCHKPHQADLVTVHSQNSSMETDSIGSAYTATRVFDNQNGDTNPHQQYSREQPVEPVTSTNSAEAQTKPNGVTDGNEHTELKQYNILIHSMLRDIEAHRSKLEGNRLLRIKNGVLNIHSGEIVRFQLEHGPSVHIDCSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PN35</accession>
    <name>A0A0G4PN35_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S024g000044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793157">
        <property type="protein sequence ID" value="CRL27789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PN35"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL27789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="69" mass="8199" checksum="0E43AC8377866676" modified="2015-09-16" version="1">MALLRDLYFNDRKLIHPHLIQLYHTPLSSDKRKRTDEDSDDETDHHNKKNPKLAIDTDNNRTVQHVINP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNR7</accession>
    <name>A0A0G4PNR7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase superfamily, zinc-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S025g000092</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793158">
        <property type="protein sequence ID" value="CRL28034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PNR7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PNR7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="13"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL28034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="386" mass="41021" checksum="32A442356F011499" modified="2015-09-16" version="1">MATHLAAVSIAKGEPFEVQTRPTPKPGPDELLIEVKSVALNPADGHMRDKGLFIPTYPTVIGFDLSGLVLEVGDNVPVGATDEGPGPFFRPGITRVAAYAASFWKSYDPNYGVFQERCLVPWQHAMPIPNEGISWNQAATLPVAVQVPLSAWDAMGIPRVGKATASPSASVAPTGAGTQENKQQKTEALLIWGASSSVGTMGVQSARLLREDRDSSFAAVYATAGAANQKYVGSLGADRVFDYNKPQVVDAIISAGREDGLVIRHCFLATGQLAPCQAVLQAFFGDDQGGENQRAKIGSAPIIPPDAEEVNGVETIFLMPSMDEGERLAHFRYWMGTWLRENLANGTIKPSPEPRVLGKGLGAINAGLDVLLKGVSCTKLVVEVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PP50</accession>
    <name>A0A0G4PP50_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S024g000146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793157">
        <property type="protein sequence ID" value="CRL27891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PP50"/>
    <dbReference type="STRING" id="1429867.A0A0G4PP50"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="1">
        <location>
            <begin position="48"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL27891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="271" mass="30978" checksum="A07075769585822E" modified="2015-09-16" version="1">MTQEDGYVLGRAIEDSVRLDAQHLLWKLHTGFELHPDIPVVENMKIAELGTGTAIWIFDLATQLPTVQLHGVDISDSQYPSKELWSPNVMLGLLDSLVDPPSSLYGQYDVVHLRMWASNLRGDDISLLSRHVKHLLKPGGYLQWEEADLVHQHIKGTEAEEFERSINDIFKKVNLDYSWVSNLPSHLQQNFHILRSEIGRFKPELVQLCTNTYLMALGEILQGIKRSLAHDMLFSIAEQEVALYRLSHTKSCIYNWSPVVILAQKRCKINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PP52</accession>
    <name>A0A0G4PP52_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S026g000092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793159">
        <property type="protein sequence ID" value="CRL28227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PP52"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL28227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="143" mass="15543" checksum="F2687B4BEF880D26" modified="2015-09-16" version="1">MPQLSSVTRSPPPSPPTSTLPARSPTKSTSEGPLVPPFIVPPGWTARPGSPSFEYEWDGVNSAGQKIARGYGLAPGRPILEDDDASTMIFQSGDKLYIWDVLYHDVYEIGSQDINEVARVLSQEGGYKKLQKCLLDPVEDIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQL4</accession>
    <name>A0A0G4PQL4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription factor, fungi</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S029g000100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793162">
        <property type="protein sequence ID" value="CRL28684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQL4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PQL4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052761">
        <property type="entry name" value="Fungal_Detox/Toxin_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425:SF2">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="197"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="536"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="558"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL28684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="623" mass="68897" checksum="356AC42761C9659B" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRF9</accession>
    <name>A0A0G4PRF9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S032g000045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793165">
        <property type="protein sequence ID" value="CRL29009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PRF9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PRF9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF6">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G00280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="7"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL29009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="308" mass="33874" checksum="17EBE1781AF6EDF4" modified="2015-09-16" version="1">MSDIKNILALGAGELGTQVLLSLAKHPNLNNITITALLRPSSISSKDQDKARHISMLYDHNILTVPGDLTNDSQESLSRIFRDYDTIIGCTGFAAGRGTQRKLAHAVLAAKVPRYIPWQFGVDYDIIGRGSAQDLFDEQLEVRDLLRSQTSTKWLIISTGMFISFLFESSFGVVNLKDNVVCALGSWDTKVTVTAPEDIGKITAEIVLGVKQKEAFSNKAIYVAGDTVSYADLALLLEKTTGNPVQRTLRTVQAAQADLANESDNAIYKYQIVFGEGRGVSWDLSTTWNYENGILGLSVKEYIERYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRG2</accession>
    <name>A0A0G4PRG2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hydantoinase/oxoprolinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S032g000050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793165">
        <property type="protein sequence ID" value="CRL29014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4PRG2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049517">
        <property type="entry name" value="ACX-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF9">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19278">
        <property type="entry name" value="Hydant_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="4">
        <location>
            <begin position="7"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="2">
        <location>
            <begin position="239"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Acetophenone carboxylase-like C-terminal" evidence="5">
        <location>
            <begin position="544"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="3">
        <location>
            <begin position="734"/>
            <end position="1270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL29014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1312" mass="141479" checksum="527D4143B48CCADA" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRH7</accession>
    <name>A0A0G4PRH7_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate aminotransferase</fullName>
            <ecNumber evidence="7">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S032g000046</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="7"/>
    <dbReference type="EMBL" id="HG793165">
        <property type="protein sequence ID" value="CRL29010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PRH7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PRH7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000066">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF20">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="8">
        <location>
            <begin position="31"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL29010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="417" mass="46723" checksum="5FB02ED2A38A46C3" modified="2015-09-16" version="1">MTHSSLSDLPVLPLAESFALTEAYNLDTFTEKVNLGQGVYRDEECQPWILPSVRSAEEFLHGQHLNHEYLPIQGAAQFTKEARNLLFTPQLAQNENITCVQTVAGTGANHLAALFCARYLRPKNVFISDPTWDNHHLIWETAGPDIKRKLYPYYDPLTRSLDFDGMIAELENSAEENDVVILHACAHNPTGIDPTHTQWEKIAEIVAKKRLFVVFDSAYQGFASGDLDADAWAIRYFYSTLFGDASLPTSATPAGMIVCQSFSKNFGLYGERIGALHLVTPPSVSPQGAYTHLVRLIRAEISCPSLFGERCVHTILTDLELRSKWEEDVKTMASRIQGVRMSLKLELENIGAQGNWDHIGRQIGMFSYTGLSKSQVHRLKEVHHVYMLGNGRMSLSGLNRKNVAYVARAIKEVVDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PS46</accession>
    <name>A0A0G4PS46_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pyridoxal phosphate-dependent enzyme, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S031g000084</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793164">
        <property type="protein sequence ID" value="CRL28916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PS46"/>
    <dbReference type="STRING" id="1429867.A0A0G4PS46"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000006">
        <property type="entry name" value="Cysteine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="7">
        <location>
            <begin position="44"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL28916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="345" mass="37193" checksum="E786B6A6A3845A3C" modified="2015-09-16" version="1">MRGYGPFYILGPQQQFAILSLRRELKPHTHAMPARPPVSTSLMLIGNTPVVRLRHVVPENCAQIFLKIESVNPTGSYKDRMAKSMIEEAERRGDLKPGMTVVEATGGSTGSSLAFLCAVKGYKFHVVSSNTFAIEKLRTMSAFGALLDLTHSPTGTITPTLIPSMIQRAEQVAKADNYYFTNQFINKDSLIGYETIGHELVEQFPQGIDAFCGAVGTAGMVMGVARVLKSKWTGTHIAVVEPGSSPTITENRPGPHSVEGIGIGYVPPHLDRHLYDEALAISEEEGRSMCRRLAKEEGLLAGTSTGLNVVAAIKLAKQLGPGKRVVTVAADTGLKYLNGGLFADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PSI9</accession>
    <name>A0A0G4PSI9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sec1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S035g000104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793168">
        <property type="protein sequence ID" value="CRL29409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PSI9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PSI9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.830.10:FF:000005">
        <property type="entry name" value="Sec1 family superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="614"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="630"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="661"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="679"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="699"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL29409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="708" mass="80479" checksum="C3CF29A7C461EAB4" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PSW0</accession>
    <name>A0A0G4PSW0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thymidylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S036g000044</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="HG793169">
        <property type="protein sequence ID" value="CRL29460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PSW0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PSW0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:dTMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006227">
        <property type="term" value="P:dUDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01672">
        <property type="entry name" value="TMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000679">
        <property type="entry name" value="Thymidylate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344:SF1">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
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    <feature type="domain" description="Thymidylate kinase-like" evidence="10">
        <location>
            <begin position="17"/>
            <end position="198"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL29460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="223" mass="24743" checksum="BD28DC6AAEE73D92" modified="2015-09-16" version="1">MADTSATPTRRGALIVVEGLDRAGKSSQCEMLRDSLSQQGHMVKYIRFPDRTTPIGQLIDSYLRGTSHQDDHSIHLLFSANRWEIAKSIEEDITNGTTVIVDRYSYSGVVYSAAKANPTLSLEWAWQPEIGLPRPDICLFLSISPEEAAKRGGFGAERYENEAMQTRVRELFRTIFEKQQDVSIIDAGKSIDEVSQEIQAAVAGCIARLDVTGALRKLEPLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PT53</accession>
    <name>A0A0G4PT53_PENC3</name>
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        <submittedName>
            <fullName evidence="9">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
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        <name evidence="9" type="ORF">PCAMFM013_S038g000067</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793171">
        <property type="protein sequence ID" value="CRL29664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PT53"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
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        <location>
            <begin position="28"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="534"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL29664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="595" mass="65527" checksum="A3BEEA02363170C9" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PTB2</accession>
    <name>A0A0G4PTB2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein S2, conserved site</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S035g000053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793168">
        <property type="protein sequence ID" value="CRL29358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="580"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL29358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="680" mass="74717" checksum="2A48D8C8EC97E386" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PTK8</accession>
    <name>A0A0G4PTK8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aminotransferase, class-II, pyridoxal-phosphate binding site</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">PCAMFM013_S036g000050</name>
    </gene>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PTK8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000364">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF54">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="86"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL29466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="538" mass="59833" checksum="7F4BF060BAE8895B" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PTY1</accession>
    <name>A0A0G4PTY1_PENC3</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Eurotiomycetes</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL29950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="226" mass="25819" checksum="B53C3C72D4A9C879" modified="2015-09-16" version="1">MTSKLLNPLAVFSRQSQSQKYIKSIKNLGDAWRTLSEESCTESDRTTVIETTFDFILKITTESDDLIVEMTTIEIPSPKLEPSNPPRHYRIFPEYGTDFLWRAEEDISDDQQGYTESEEELVSFPSSVLEVYNAWVDEWSANWEKRIKDTQDYHAPVFSDRIEQVAWNVAGYMLAWRIVLGPGVGSIEYTPGSTDYLLERGKESAVTERFLRDQIGLLAMGAEGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PU49</accession>
    <name>A0A0G4PU49_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine/threonine-protein kinase DCLK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S041g000060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
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                <person name="Bensimon A."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793174">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1429867.A0A0G4PU49"/>
    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="166"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL29918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="405" mass="46865" checksum="96E2A98922C6566E" modified="2015-09-16" version="1">MPATAAPPLVTTPGLELMSYCEDRDFRAEGKPEPNSRSQTLVYYSQDKKWWIRVTFKRAISCFTYDAEPEQIKSKRERRNEFQDFVRLIDFRPLALLDNTLTEVIFLNGDPETTEPIKLYREPEDTNRFTKLVKNLRFYIRKDPLRVVYPLCLQFPSFRAINVVELKEEDEIADGVFRVLYKRDKKPYILKVVNRPFYQPRDSDVIQKELENLEQFKGVVGIVQPASIAVFANPYATSQNCAKQMVISGILLEYYSGGSLQRVFNEKRIREFDWERWAVQIGNALDIFHRAKKTHMDIKPSNVVLDDDGNAVIIDISGIGGVTHEWRAPEIRDEISPFDLPFQTRRLNDIWAYGKLLTEIALNAGNSPFAGTLRLVADHLTEENVRNRWTLSEGIESLVENLSVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PU95</accession>
    <name>A0A0G4PU95_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="7">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S042g000027</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="7"/>
    <dbReference type="EMBL" id="HG793175">
        <property type="protein sequence ID" value="CRL29968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PU95"/>
    <dbReference type="STRING" id="1429867.A0A0G4PU95"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044322">
        <property type="term" value="C:endoplasmic reticulum quality control compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904380">
        <property type="term" value="P:endoplasmic reticulum mannose trimming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044674">
        <property type="entry name" value="EDEM1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679:SF5">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195742" description="alpha-1,2-Mannosidase" evidence="9">
        <location>
            <begin position="24"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="582"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="741"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="763"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="467"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="488"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="574"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL29968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1037" mass="114489" checksum="7F45625DED764ADC" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVJ9</accession>
    <name>A0A0G4PVJ9_PENC3</name>
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        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
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    </gene>
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793178">
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="52" mass="5808" checksum="05B20E6C475AA35A" modified="2015-09-16" version="1">MDSELFRSEVSSGIYLILHSKSQYKYGKTQTDANPDMVEREGGGKEEPDNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PX34</accession>
    <name>A0A0G4PX34_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MYB-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S059g000007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="194"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL30766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="251" mass="28066" checksum="7821A632BF693E5B" modified="2015-09-16" version="1">MFIWVRSIDLPVLDRNKAIDPAILDDHAFPGGEQTQTTENTTNIAICPDRCLLECSHSPNQDPPVQSRRQNAKGTAVPGRQSKINKRSSAEKRYSKHGAARSNKGPHRRSSVSFPTVRAQFSALPVEDRLEFLSWLFEGALSHCISTPLSTDATVPRCIANQDSDITYDCDQPSRNTELVDAQHTPCMRKGLLWSEEEVSLLVKLGEGQNLAWSEVTRQFAQKFAGRSKGSIQVYWSTTLKKQRRSLEVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PY50</accession>
    <name>A0A0G4PY50_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S073g000005</name>
    </gene>
    <organism evidence="3 4">
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793205">
        <property type="protein sequence ID" value="CRL31074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PY50"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="GatC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049545">
        <property type="entry name" value="Gta3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004:SF0">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20978">
        <property type="entry name" value="Gta3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl-tRNA amidotransferase complex subunit Gta3" evidence="2">
        <location>
            <begin position="59"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL31074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="191" mass="20934" checksum="F5573C0C36C1AE03" modified="2015-09-16" version="1">MTSLRTAARLSKSLRPGPSRLNTTFSRFYSSEKSDSADIELILGAPNWSVRSLLPNPASKPPPSITPKQLHHLLRISALPQPANQEEEQSMLDTLESQIHFVKEIQLVDTTGVAPLARIRDESPAAIEEETIGIEKLKEALAKEKVSGRRGKIQRVPGEKNDRPDGTAWDGNALGSATKTKGKYFVVEIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PY83</accession>
    <name>A0A0G4PY83_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S076g000007</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793208">
        <property type="protein sequence ID" value="CRL31114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PY83"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF91">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="159"/>
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</entry>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <end position="31"/>
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        <ligandPart>
            <name>Fe</name>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL18124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="490" mass="56456" checksum="356481AB7BF763A3" modified="2015-09-16" version="1">MGIIFDVQYALATGLFTATLYLVYTVIYNVYFHPLSRFPGPLAHKISRLAYVYRSIRGTLPFDMLEMHKRYGDIVRIAPDELAFSHPDAWQDIMGHQKGKPEFSKANWFYRPMEDQACHVVNESREQHGRLRRQMAHGFSEKAMRDQEPMIRGYVDIFLDRLHEFCESGTPVVLSDWYNYATFDIIGDLAFGEPFGCLQGSNLDGWIKGIFDAGRLGIVLQALSFYPSVKRTLLSMVPASMTEAHEKHKKFTEQKMMRRMEKEEGRPDLIEGLLRKREELNLSIDELIANAEILIIGGSETTASLLSGVTYLLLMNPTAHQKLKEEVRTVFQSQEDIDLISVNKLPYMLACLDEAMRMYPPIANGLPRVCPEGGAKVLGEYVPANTFVSVHQWALYRRQEYFKDPNTYHPERFLGDPSFADDRREVLQPFHTGPRNCLGRNLAYSEMRLILALIIFNFDMEIADEARDWIKQRNLLMWEKGPLKVHLTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NVZ9</accession>
    <name>A0A0G4NVZ9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Thioredoxin-like fold</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S002g000105</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative mitochondrial redox protein which could be involved in the reduction of small toxic molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMP46 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NVZ9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012882">
        <property type="entry name" value="Fmp46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28071">
        <property type="entry name" value="REDOX PROTEIN FMP46, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28071:SF1">
        <property type="entry name" value="REDOX PROTEIN FMP46, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07955">
        <property type="entry name" value="DUF1687"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="34"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL18235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="16810" checksum="4FB602F8425CCAA9" modified="2015-09-16" version="1">MFRFSKTLDPITLFHSPSIQASTRTLNILKQASATASETATEDQASDHSTHSKQQRGEFELEVTTSPPTTDQLRSILDYVSSVSGVGSPGDKVTYGVAELVKGARDAEDALKKFKEDNENFVRPITVDWVNGRAVIGDNQSEILRMVRQLPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NW32</accession>
    <name>A0A0G4NW32_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S002g000049</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NW32"/>
    <dbReference type="STRING" id="1429867.A0A0G4NW32"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="149"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="200"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="408"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL18179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="430" mass="46396" checksum="BA53FD00157AD23D" modified="2015-09-16" version="1">MSGNPNDHDPNRQGDLNRQDPRDPRDTRDPRDPRATQWNNPDDQASYPYPPTSYPPPPDQDRAYQYPPPAQYAPSQYPPPPQYAPSQYPPAQYPDPRYPHPQAMNAIHGAQDPYRLPPPPGPYRADAYGPQAGQGPYQAAAPRQRTAIACRYCRRRKIRCSGFETSADGRCSNCVRFNQDCMFTPVSSQTQAFVPAHTAYPHLRPGQNGPGPGGRGGPPVLYGAHGQPLPPQQQPQGPETTLPPPQGMYYQNGRPPMDGAPLPLASTMPDPRHRRGSNSGFEYPDPTNLAPVTPAGSAPGYQTHTTPSPYAYPPPPAHDRRTSPPSAYNYDARPSSSPHGSPFPPMQAHQAPMTPHQGSVPPVSAQQGSAPLKSSGTPQPGGVTPPPTSTPGGSQRGGLNVRDMLNPGDSQGRSSTDSDMLNALNRRGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWW5</accession>
    <name>A0A0G4NWW5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S002g000492</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWW5"/>
    <dbReference type="STRING" id="1429867.A0A0G4NWW5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Dupont J."/>
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                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Bensimon A."/>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <source>
            <strain evidence="3">FM 013</strain>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="CRL19827.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="62" mass="7068" checksum="D045A60104967573" modified="2015-09-16" version="1">MVVEPYLCCRSLLDKIKLADVLFLFTFVVEGFLGYLLTPLLEAFSYFSLLTVMAPRTTRSQS</sequence>
</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Dupont J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway.</text>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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                <person name="Abraham A.L."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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    </dbReference>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="201" mass="22193" checksum="768C6B613387283A" modified="2015-09-16" version="1">MATGPATQSLKCVVTGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYTASVMVDGRPISLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSIVSPPSFDNVKAKWFPEIEHHAPNVPIILVGTKLDLRDDRATTEALRARKMETVSYEQALAVAKEIRAHKYLECSALTQRNLKSVFDEAIRAVLNPRPATKSGRKAVKCNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P1P5</accession>
    <name>A0A0G4P1P5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vacuolar ATPase assembly integral membrane protein VMA21-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S004g000149</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Renault P."/>
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                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle</location>
            <location evidence="6">COPII-coated vesicle membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the VMA21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03058">
        <property type="entry name" value="VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019013">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792">
        <property type="entry name" value="VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21"/>
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    </dbReference>
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        <location>
            <begin position="34"/>
            <end position="55"/>
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        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL20209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="107" mass="11287" checksum="9A5F08D61D34B23A" modified="2015-09-16" version="1">MSARRPHNQSYADVTAKPAPQGTSDVAPAVPADVIYKLLGFTAAMIAGPIGMYFLTVNTIFSGSSTLAGITAAVTANVVLFAYIYVAWTEDQEDRQAASKSDSKKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P1Q1</accession>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
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                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="21"/>
            <end position="71"/>
        </location>
    </feature>
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        <source>
            <dbReference type="Pfam" id="PF13508"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL20251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
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</entry>
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    <accession>A0A0G4P1V4</accession>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL20300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="58" mass="6406" checksum="1AB0EAEEA564795D" modified="2015-09-16" version="1">MAVIAPYADVHKDPQGPGDARPTALQVVKDAGLVGKMKDQGKSWKPFTQYRLCLTLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P300</accession>
    <name>A0A0G4P300_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S004g000569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL20628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="57" mass="6506" checksum="CE509EC84E4F557D" modified="2015-09-16" version="1">MYTDTGGRLHRISRGALVRWCYGLIHLSYRGRAGDEHVGNILFWSGMMHVLDPLLCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P347</accession>
    <name>A0A0G4P347_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AMP-dependent synthetase/ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S004g000609</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
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    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="104"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="587"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="5">
        <location>
            <begin position="702"/>
            <end position="943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL20668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1085" mass="119899" checksum="4FB564121EB0A858" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3R2</accession>
    <name>A0A0G4P3R2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Terpenoid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S005g000149</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the C-terminal section; belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the terpene synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL20985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P3R2"/>
    <dbReference type="STRING" id="1429867.A0A0G4P3R2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF72">
        <property type="entry name" value="THIJ_PFPI FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G01210)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="370"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL20985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="764" mass="86078" checksum="F3FC0C5AE96826A6" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P460</accession>
    <name>A0A0G4P460_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger, C2H2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S005g000226</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4P460"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF30">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="78"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="108"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL21062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="345" mass="37750" checksum="B3B9B3BB0FD2F5E7" modified="2015-09-16" version="1">MTRGSTGRISPNHIVSVLNSPSVSSSSSPEPQQIASKSNMAGRKNSIRTASPADATMPVTYTPTTHRISKAKKGKRVHACQYPACGKVFTRAEHRRRHELNHNPEASYRCATQGCKKAFHRADLLARHMERHELESQPEQSSWASNNQQPIAPESAVPRCMSMDHGMPLTATSHSHSMSIGSLVAPGIHPDLANNDCSLMWSGVDLPLQPRPAFHSQLPESVDDSPFYSSPPETCPSPLSDATFSLPPHSSSSISSASVSVIDQYPKNILKGDVTSSPLQMHTPLRWETDAGMPPSHLVPMSMGENMIQPPVQCHYPSPPWSSAECLPYEDQVHSMHQFPVTWGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P4Q7</accession>
    <name>A0A0G4P4Q7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S005g000426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P4Q7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL21262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="59" mass="7072" checksum="13533759677C8EA0" modified="2015-09-16" version="1">MCTNPVQRFTFLALDNHILAKCSKFWLSYQRGRLSKYRFLYLIMPASMPLEICCFFFPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P592</accession>
    <name>A0A0G4P592_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Chitin synthase</fullName>
            <ecNumber evidence="2 9">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S005g000608</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chitin synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 9"/>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P592"/>
    <dbReference type="STRING" id="1429867.A0A0G4P592"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
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        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF39">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="571"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="620"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="650"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="700"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="732"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="846"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="867"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="11">
        <location>
            <begin position="134"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL21444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="902" mass="101748" checksum="DA3B304065CAB7D0" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6R2</accession>
    <name>A0A0G4P6R2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NADH:flavin oxidoreductase/NADH oxidase, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S006g000557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
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            <taxon>Ascomycota</taxon>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL22017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="63" mass="6840" checksum="5E0B0C59F8653097" modified="2015-09-16" version="1">MNGPTIISSAAKVFPNVPRVWSQEQVQAWQKIVHAVHAKGVLHLASALGYRALCRGGNISFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P763</accession>
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    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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                <person name="Ceppi M."/>
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                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586:SF0">
        <property type="entry name" value="TRAILER HITCH, ISOFORM H"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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            <end position="82"/>
        </location>
    </feature>
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        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL22142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="113" mass="12454" checksum="CA834AD46434A5F7" modified="2015-09-16" version="1">MEMNHLIGQRFNLISKSDIRYVGTLHEINPEASTIALENVMSFGSEGRRGNPAEEVPPSTSVYEYIVFRGSDVKDISIAGEEQKDPAPQEAPRVPDDPAILGVSHHTPILWAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P8Q0</accession>
    <name>A0A0G4P8Q0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S008g000127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P8Q0"/>
    <dbReference type="STRING" id="1429867.A0A0G4P8Q0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL22698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="239" mass="25758" checksum="F0C6C51652820B52" modified="2015-09-16" version="1">MKILMVHGSRQSGELFRAKLQALEKLIHRALGPLHPGVDLVYPTAPFALEPSSGTTSDLRSRHGAWSWFESESIDGLYPGLEGGLESIASILKDSGPFDGIVGFSQGAAVAAMVASLLEGNRKDAFARLEAEGGIPYPACFANLEHPPLRFVVSISGYVASHLDYRAFYDPVIRTPVMHFLGSMDTVVDESASMRLVDSCQEVGDEKKQVVVRHSGGHVVPSGKRELAAVAHFIKCNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P9G3</accession>
    <name>A0A0G4P9G3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S008g000376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P9G3"/>
    <dbReference type="STRING" id="1429867.A0A0G4P9G3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195157" evidence="2">
        <location>
            <begin position="21"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL22947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="192" mass="18735" checksum="9BB96F1E52AFC383" modified="2015-09-16" version="1">MKFTAAIGVAALFMAPSAAAWKLPHANKADAAAPTGSPSSSFPGGFPSGTPTGFPSGTPSVTPSGTPSGTPTGFPTGWPTPTGFSFGRRAPGHGPGIKGPGHGGHGHGDHGHGSESTGFPTISPTSSPIGSSTAVPSGFPESTGVPPGFPGGFSGSQASSGSFTVLPVATATAATVGEQGDFTRRHARHMLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P9N7</accession>
    <name>A0A0G4P9N7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Flavin-containing monooxygenase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S008g000456</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL23027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P9N7"/>
    <dbReference type="STRING" id="1429867.A0A0G4P9N7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF4">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="539"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL23027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="569" mass="64211" checksum="3CDCCF9091BE2DDD" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PB42</accession>
    <name>A0A0G4PB42_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S009g000455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PB42"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL23515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="143" mass="15785" checksum="1E03E325E9DF84F1" modified="2015-09-16" version="1">MSITPITPTKPLTAQLLRAISQFFREMDNPQFMIEHGDVATYIVSSAPCDDSPITTDLLSGILSRHIGYAPPTLIKNLMGSNAGNTDLECMVVLYSLLMTDILPPSSLRTSIKRILYSHNGEDLMRHLVDNLEIGVESQLGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBK9</accession>
    <name>A0A0G4PBK9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Homeodomain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S010g000146</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PBK9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PBK9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 5 9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="211"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="213"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="271"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL23708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="594" mass="66893" checksum="1116350F076DCE20" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBQ8</accession>
    <name>A0A0G4PBQ8_PENC3</name>
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        <recommendedName>
            <fullName evidence="12">Threonine dehydratase</fullName>
            <ecNumber evidence="12">4.3.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Threonine deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S010g000204</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from L-threonine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="12"/>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PBQ8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PBQ8"/>
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        <property type="reaction ID" value="UER00054"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04907">
        <property type="entry name" value="ACT_ThrD-I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1020.10:FF:000001">
        <property type="entry name" value="L-threonine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000008">
        <property type="entry name" value="L-threonine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1020.10">
        <property type="entry name" value="Biosynthetic Threonine Deaminase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001721">
        <property type="entry name" value="TD_ACT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038110">
        <property type="entry name" value="TD_ACT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005787">
        <property type="entry name" value="Thr_deHydtase_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01124">
        <property type="entry name" value="ilvA_2Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006674">
        <property type="entry name" value="PRK09224.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF11">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00585">
        <property type="entry name" value="Thr_dehydrat_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACT_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7 12" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ACT-like" evidence="14">
        <location>
            <begin position="388"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="ACT-like" evidence="14">
        <location>
            <begin position="484"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CRL23766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="566" mass="61811" checksum="21978ED77E765759" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBT5</accession>
    <name>A0A0G4PBT5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Synaptojanin, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S010g000211</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="CRL23773.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="703" mass="79471" checksum="1E2B607C9E3BE7B2" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
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                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="31"/>
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    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <sequence length="419" mass="46047" checksum="3DA53AE2CF980F0F" modified="2015-09-16" version="1">MVELKPIFKKAYWSLAAGGLLYVLCLLSLTFPEVQRFVLYANKINPSLWQDVNQVEQFGFLRTQVQPFHLVTPDNETIYGWHLMPLHLCLEHEKELMENPSTGPAKDYTKTVAHKLLANDPNARVVVSFHGNAAHLGSAQRPATYNSMLSLSTPSNPVHVFAIDYRGFGVSTGTPTEEGLITDGVSLINFLTAGPLKVPTSRIVIVGQSLGTAVTTAVAERFAFGSSNLAAAQPAIKNAEPFAGVVLLASFSSLANLIESYSFKGLTPPMLSPIMGYPRSQNWLLSHIVDHWDTAGRLARLTGVNTTSVKAVDMEYTNKSLDLTIVHAFDDAEIPWYEGRRVWEAATGRHIKGAPGSMTYHKAEDGNPSEVKIWKNEISNQDGTRIVKTVRWERIRYGGHNRVASGSVAGLAVMRAFEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCH4</accession>
    <name>A0A0G4PCH4_PENC3</name>
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        <recommendedName>
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        </recommendedName>
    </protein>
    <gene>
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    </gene>
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    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Vacuole membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="protein sequence ID" value="CRL24007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1429867.A0A0G4PCH4"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Atg22-like"/>
    </dbReference>
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        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF2">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0029">Amino-acid transport</keyword>
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    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0926">Vacuole</keyword>
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        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
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        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
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            <end position="313"/>
        </location>
    </feature>
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        <location>
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            <end position="410"/>
        </location>
    </feature>
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        <location>
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            <end position="440"/>
        </location>
    </feature>
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            <end position="59"/>
        </location>
    </feature>
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            <end position="53"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL24007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="552" mass="60895" checksum="A92E072BDBAE5747" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCQ3</accession>
    <name>A0A0G4PCQ3_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Microbial-type PARG catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S011g000119</name>
    </gene>
    <organism evidence="3 4">
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PCQ3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PCQ3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012664">
        <property type="entry name" value="CHP02452"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019261">
        <property type="entry name" value="PARG_cat_microbial"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02452">
        <property type="entry name" value="TIGR02452 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596">
        <property type="entry name" value="DUF2263 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596:SF1">
        <property type="entry name" value="MICROBIAL-TYPE PARG CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10021">
        <property type="entry name" value="PARG_cat_microb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Microbial-type PARG catalytic" evidence="2">
        <location>
            <begin position="183"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL24125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="409" mass="45237" checksum="E85D0D659ABCBD34" modified="2015-09-16" version="1">MPKKEEPAQSDTSRSTQSTESTGSKFANQSPASSKSSQSSSGLTGLIDTIAQKFSSASTDSSISKVSSDVIMGGLDSREESPDPLTSPETKSGFSLSPKGQPDVLKKKHPAQRPAQAKKRRPSIRGKKSKVKGVNKPQSIAMNKVITTTKQATKTILSRTELEGTRFGYIANRWTAPVLDPNSVEFPNVDTVIRVAVGDTYDRALEMQNADSATDHMPVCVLNFANAYRPGGGWLNGARAQEEQLCYRSTLIDTLHTRFYPMDDLECLYSPNVIVFRNSVDNGYLFMSDDEKLHLNPTVSVISMAARSQPKLTDDKSTYVEVGHRYLMIAKMKLILRAAANNNHRRLVLGALGCGAFHHPTQEVADCWYEVLMKKEFKGWFEQIHFAVRDAPKENNVEIFKKTLDGLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCS6</accession>
    <name>A0A0G4PCS6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S011g000048</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PCS6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="342"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="49"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL24054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="441" mass="47384" checksum="148ACAC5DE379AA0" modified="2015-09-16" version="1">MSSETDKHLALRDPPVSLPAAESDESESEKQTADQPAVPPPPPNGGLTAWLQVAGAFFLFFNSWGVVNTFGVFQSYYEETLLPGYSASSISWIGTVQGFLLFIVGVVVGPVFDKGYLKTLIAIGSFLVVFGLMMTSLSTEYYQIFLAHGVAVGAGCAFLFLPSVAIVATYFTSRRAVATGITASGGSIGSVIFPSVFHKLIGPLGFGWTTRVIAFIALGGLLFSLAVMKMRLPPPKQARRLIDPSAFKESPFIVLSLALFFAFIGLYFPFFYLPTFFTSYLHSNENIAFYSIAILNAASVFGRITPGLLADRFGSLNTIIPISLIATILAFAWIGIRNEAGTIVFAIIYGYASGAIVSLPPTIVAKITADMSIVGTRMGMCFTFAGLGLLIGNPIAGALLDLENAVFWKAQLFSAMTVVTGAALFIVLRFIKWKHGEGWKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PD11</accession>
    <name>A0A0G4PD11_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA mismatch repair protein PMS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S011g000204</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PD11"/>
    <dbReference type="STRING" id="1429867.A0A0G4PD11"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000710">
        <property type="term" value="P:meiotic mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03484">
        <property type="entry name" value="MutL_Trans_hPMS_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000074">
        <property type="entry name" value="DNA mismatch repair protein (Pms1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.100:FF:000001">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000014">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF52">
        <property type="entry name" value="MISMATCH REPAIR ENDONUCLEASE PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="6">
        <location>
            <begin position="219"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="5">
        <location>
            <begin position="779"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="387"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="411"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="446"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="522"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="537"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="555"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="598"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00070941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL24210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1001" mass="110887" checksum="7BE694691B807076" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PD60</accession>
    <name>A0A0G4PD60_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">beta-glucosidase</fullName>
            <ecNumber evidence="11">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S011g000260</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="11"/>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PD60"/>
    <dbReference type="STRING" id="1429867.A0A0G4PD60"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF2">
        <property type="entry name" value="BETA-GLUCOSIDASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 11 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195437" description="beta-glucosidase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="14">
        <location>
            <begin position="780"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="674"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CRL24266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="870" mass="93780" checksum="E38712751ABEBBD0" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PD91</accession>
    <name>A0A0G4PD91_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S011g000246</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PD91"/>
    <dbReference type="STRING" id="1429867.A0A0G4PD91"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="62"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL24252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="389" mass="44896" checksum="B862E7B917F94DF4" modified="2015-09-16" version="1">MATIMKWATKAFRRPPSPLLCFPTSGFETVRPSEVLEEERFEQFKQGQYYPANIGDVLISKYQIIGKLGFGTTSTVWLARDLEGHQYVTLKIYTRDAGNQEEFQIYKQLNLGRSWHPGHAHVRKALDIFTIPSSGGGHPCLVQNPMWESFRDLLCRNPNHRFTEDLLKSGLMQIFLALDYLHTECKLVHTDIKSDNILQEIEDKSILESFTQAELKNPSPRKIVNGLPVYASTFRLAEGDERRNHDAQPSVYRSPEVMLKTDWSYPVDIWNVGVMVWDLFEGRHLFYGNDPDGKGYSTRAHLAEVMGILGPPPLDMLQRGKRSHEFFTSDGRWKQDIEIPTGVSLELSEKFLEGRNKEMFIAFMRGMLQWRPEDRKTAKDLLQDPWLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-11-27" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDB2</accession>
    <name>A0A0G4PDB2_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MICOS complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S011g000233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PDB2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PDB2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044284">
        <property type="term" value="C:mitochondrial crista junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019166">
        <property type="entry name" value="MIC26/MIC27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033181">
        <property type="entry name" value="Mic26_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28268">
        <property type="entry name" value="MICOS SUBUNIT MIC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28268:SF1">
        <property type="entry name" value="MICOS SUBUNIT MIC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09769">
        <property type="entry name" value="ApoO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL24239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="252" mass="27264" checksum="4DB9CB0DB7BC501F" modified="2015-09-16" version="1">MSFRPMLQQRAVAPIAATLLAGGIALFPKKTAFAEEPRDNRKPIYDDFPADIPEPSKPSQLAAPAAPKLISAPAAQLAPSSPTPTDILTAQVRQARLFLYSHSLAAEQGFNNFLSRALNIENCFTNTVASLAPSAESGERLLPGGVYVVVTAMAGSIVSRNRGIFLRTASPLAFGTAAAYTLLPVTMRNVGDLVWEYEKKVPALAEKHSAVRERAEHIWFTGIAHSGMARQMMEEKIGDTRKKLEQLVSKGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PEC9</accession>
    <name>A0A0G4PEC9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S012g000231</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PEC9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PEC9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL24621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="450" mass="50802" checksum="6452D1CDF03F5839" modified="2015-09-16" version="1">MPRPLERNLASKSITNSRLLSQTCRSRRVKCDGKRPKCSPCQRIARNCHWVQEEDTIAAPGVPVSQPSPLSSSVHHETEYPSTEHPEYALQDQQVAKLFRHYIGTLAAWYDLNDSKRHFKDVVPVRARYNPLLLSAILAFAAANQHRTLAEDGYLEIAEFYHYDSVRRLISLTKNIDRIPLGETLAAICLLRSYEIITQNVSSQSHLQGCYSLLASRHIHLTADLLSAGYWNYLREDITVALIEQRGLMITLSDQNAPPEPTEDADFANHVTFLLGKIINRCLSVDSQALTPSEWEATKADLDKWKSSLPSSFDTIQTPGLRKQSSFPSIWALRSWHVSTLHYYHTAMGILWLAQPAAQPLKALQRINDMECLRRKLEYHATEICALALSSDSAPVWVNAFGPIAFCSPWLHDTQKRVEMAQELEKWGKVTGWPVSIIAEALSPPSNTTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PEF9</accession>
    <name>A0A0G4PEF9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S012g000269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PEF9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL24659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="144" mass="15837" checksum="17AB777442FEC4FB" modified="2015-09-16" version="1">MSPLPVIACGSSNPQIFNAVKPLYLPEYEIIHNVISSTSGAVEIPALLQGRTPPIAKEPNRGTMNYSKPPVAVFTGALYGDKEIDEMRQVCQGISSIPWLKMDMSVPKPPLGPGYAEHVVQRIKECMKKIEAEGKLEQDGVWLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PEX1</accession>
    <name>A0A0G4PEX1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S013g000127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL24884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="57" mass="6077" checksum="E577CB16BF7C52B3" modified="2015-09-16" version="1">MTSLSAGQGKEIPGAADLGPGPLARGHPEPFGAVGEKELHVPSETIGRFRHMLFTWH</sequence>
</entry>
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            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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            <end position="53"/>
        </location>
    </feature>
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            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL25062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="121" mass="13266" checksum="52E13C9C0726E9E0" modified="2015-09-16" version="1">MVLDWSALAPGPAGTAMLGESGIEGAARRGRERTRREQAEQREVEKKPQHGDDTGSEVTLLPENQSKELESKPEGSKKAGDLTPRSLMGFDADTLTEQSDGRRQRGGIKKKMSRFKKQLTG</sequence>
</entry>
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        </submittedName>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
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                <person name="Lacoste S."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CRL25110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="51" mass="5830" checksum="36BE2CE903E63847" modified="2015-09-16" version="1">MGTSWGQVNVGNLSWSAARIPPKRTSNDRSKSAPKYHDEFRFALRLVRNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PFS6</accession>
    <name>A0A0G4PFS6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S014g000048</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
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        <location>
            <begin position="18"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL25152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="349" mass="38130" checksum="F5634788716CFABB" modified="2015-09-16" version="1">MHTILLTITTLASFALAEYRPEERVVLADCGIHPPNGDSTSRQIMYYHDAPWASQGTRGKWVTPDMMTDVPWDGSYPWRTKGLKRKMPNGDEFSIVIDPSIPDSNDKFAGLAGHTFEPHGFGCRGHHERGIYILDDGTECASAYICDHKTETRPGPAPAPAPPAGTTTSSLTLSSDAIYVDDSNLYKDKLRLMNPSDAFHSVYDAIEGNGCRKSDFAISDSCTISYNCMFAGEKNDAKSRSDAVAKFLHGTAGPQVSKSWYEKTTYSQQWGVPTYWIGYKYPRSGQIVITHDNSIQSQLSFEVKCKGSWFCDVGCTEVTTGMLALGYAQGMAPVGVFGTLTAGACGLFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PG02</accession>
    <name>A0A0G4PG02_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S014g000128</name>
    </gene>
    <organism evidence="7 8">
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        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM170 family.</text>
    </comment>
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    <dbReference type="STRING" id="1429867.A0A0G4PG02"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL25232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="136" mass="15438" checksum="052E9A7EE4AAE2AA" modified="2015-09-16" version="1">MANNRVPINYEVPSFPSLYDPLPVNHQQAYYLYYTKDIWRFTLFWTLIFYGATHLTVAGCAVLTHFRNWNVIWIVPLVYIFIAALESLLAGSIIGVVLGAVYEAGNFRMSTWLPMIWGGVNVMVLIVTSFPMQGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PH20</accession>
    <name>A0A0G4PH20_PENC3</name>
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        <submittedName>
            <fullName evidence="5">Carbohydrate-binding WSC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S015g000260</name>
    </gene>
    <organism evidence="5 6">
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793148">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PH20"/>
    <dbReference type="STRING" id="1429867.A0A0G4PH20"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861:SF9">
        <property type="entry name" value="CELL WALL INTEGRITY AND STRESS RESPONSE COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861">
        <property type="entry name" value="GLYCOPROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195333" evidence="3">
        <location>
            <begin position="21"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="21"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL25674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="328" mass="33182" checksum="C12BBEAF59205E3E" modified="2015-09-16" version="1">MKVAEVVSVFVLLARPFASAATSLTYCASVNTGSSFSAVSDTYQSNGACLKTCANYALGILQGKKCWCSNVAPSKSSQASDTSDCDGACPGYPSDSCGSASKGVFAYLEITGNDVTSTAGGSTTSTTTSSSSTSTSSSSSTSTSESTSVQPETVTSTSSDTTTSTSSTVSVQTNAGGQVKTITVAGSSATAGADSGSASTTPTSSKLSGGSIAGIVIGVLGGLALIGALIFLIFFYRKRARSISPIPSQEMADDRTSRGSSFMGGLFPRNNGEGAAGGSIPARSGTTFTDRRMKTNTILYPNGARESSVSLQDNEDYSRPVLRLTNPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PHA1</accession>
    <name>A0A0G4PHA1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Low temperature viability protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S015g000218</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTV1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793148">
        <property type="protein sequence ID" value="CRL25632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PHA1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PHA1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007307">
        <property type="entry name" value="Ltv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21531">
        <property type="entry name" value="LOW-TEMPERATURE VIABILITY PROTEIN LTV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21531:SF0">
        <property type="entry name" value="PROTEIN LTV1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04180">
        <property type="entry name" value="LTV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="217"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="449"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL25632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="494" mass="54010" checksum="ED1D278870F43BA2" modified="2015-09-16" version="1">MPPKQWIDKKNASKFQLFHRSQNDPLIHDTSADDRFLYQVGGPAPAPASTTSKKLPNLDDLRTEYGDSARENEGEAANYGVYYDDSSYDYMQHLRELGSGTGDAYFVEAKNEKAKGRAGRGMKLEDALRQVSLVDKDTYGQGTSTGPSLYGSQYGDMRSTASSFVRKPTYQDQQNVPDAIAGFKPDMDPRLREALEALEDEAFVEEGDADGIFGELTANAEELDEGDWEDSLFDHDVEDDGWESDATEKAPVQPDSTEAHRSMDTEGPAKPPMEPGEMPEHDEPAPDMEPTDQSWMNEFAKFKKDAKAGNAPVPAAPTIAASQTMASTVFTAGGTPIRRKKRKGALTNPSAYSMTSSALARTAGHRLLDDRFDKVEQLYSLDEEDEYDDSMSMISGMTGATGMTDMSTASSQAPSLIDGNGEAVHSRSTFNNVMDDFLSSWDPNTSGQAKRHGAKHKRGRNGNEAIGIRMLDEVRSGLGPARVRPEKAKVPARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PHZ3</accession>
    <name>A0A0G4PHZ3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S017g000023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793150">
        <property type="protein sequence ID" value="CRL26040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PHZ3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PHZ3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL26040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="127" mass="14557" checksum="CF5507709C99BE3B" modified="2015-09-16" version="1">MSSDRLNRPKPVTYPDPDRTGGPMDLIHVATIKRGQNKVPCRFVMNTNPTAYALVYRTKEKKDLSYCRLQDLQGFSERVCDETHDFPSLAFTATRPYDASYLDILLVIERNTTRPMVKRTPESAPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PIJ9</accession>
    <name>A0A0G4PIJ9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase superfamily, zinc-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S017g000210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793150">
        <property type="protein sequence ID" value="CRL26227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PIJ9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PIJ9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05188">
        <property type="entry name" value="MDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF4">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="1">
        <location>
            <begin position="77"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL26227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="400" mass="43830" checksum="8E05D8408C35B9B4" modified="2015-09-16" version="1">MVHLTMSHQHPSISDTRVHPTHHALILRPAPFTKPQVEEIPIPSLLPGSVLLRSLATPLHSYSKLCLEFYNPARSPHQKPFIPGSSAIARVSRVGDDATILEVGQLVLFDSVMKGRDSPETVRFANPVCRGFDLHNSELLASSGFADGSYAEVMRAPLENCYPLDEAKLMGDPRQWGFAYTPEQLCAFATFLRPFGGLSSIDVKPGETVLISPATSPNGAAACMVALAMGANVVAWSHDGAKLVHLNHILSQTHNGSCGRISTITWTGNCTNDTRNIIKRFGPMDAFLDISPSGTGESFHLKSGIMSLRPEGRVSLMGAYETLEIPNLFVTRCNITLKGNWMYERNDILALIKMVEKGNLRLKEADRYYVVGEFGLHQWREALTAANQLTGIGESVVFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PIL9</accession>
    <name>A0A0G4PIL9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S017g000253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793150">
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    <dbReference type="STRING" id="1429867.A0A0G4PIL9"/>
    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL26270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="345" mass="38586" checksum="EAA1BCA386222B25" modified="2015-09-16" version="1">MEAVGSSDGQTATMKFSKETLDLESNTRFEYDPWLLDDHPLRSHPTECIPGLSLYLDEYYESIGKRRAILFRAACLILGCLAAFQCLRLLPTNIKRILPPHASIQHTHIHPQNSACTFPTLDTRPGALKSSLNEGCDGLRTAVWMHHGELQIGNAVTETEPEDFLQRLGLDPLLAKLDAENDATARPSLNPETPGGFHADLAQTFLLMLDAKTPLHELYPHLVEQLDTLRQRGYLSHWDGQNVVQRPVTVVVTGEAFPESDCVNHSYSDVFWSALPEGRFPTSELTKDNLRHLSPEVDKVIHFGILSALNLQPRVSAGYQFQGAFLYDLFPFPSGESPNYPLERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PIY6</accession>
    <name>A0A0G4PIY6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S018g000035</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATG33 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PIY6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PIY6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051668">
        <property type="entry name" value="ATG33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37278">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 33-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37278:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 33-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL26342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="210" mass="23614" checksum="B24BCA3B6EE0C6E5" modified="2015-09-16" version="1">MACPISVSKFVGTVSLGLLTGLSYSTSSITIPALQLLPTATTAARSLNEVKRLTRRYALRLSFLANSCFCFAWCLSSPRRRHPYMVWLWAFSTISAHGVDFWFNRHLGFKNWVSAVIRDVSHFSLIRDSNTNKDEDLVVVEAQDDVNGETVQREMDRERRLHRARTWLSGIALSIGIVGLWGDKRNGVTSKLESGISEPHLLDGQIHQPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJ28</accession>
    <name>A0A0G4PJ28_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HPP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S018g000027</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJ28"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJ28"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007065">
        <property type="entry name" value="HPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058581">
        <property type="entry name" value="TM_HPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04982">
        <property type="entry name" value="TM_HPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="HPP transmembrane region" evidence="2">
        <location>
            <begin position="28"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL26334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="228" mass="25002" checksum="C90558002FCD5EA7" modified="2015-09-16" version="1">MATSRLARLPRWISHWLGYRPEAVKPLSQYEVALWSFITSFCGLSVVQAIFNYSDYFTERNVPGIIASYGASAVLVFGAIESPLAQPRALVFGHFFSALIGVCVTKLFSLMPDQARFESLRWLAASLSTAIAIVVMQLTGTTHPPAGATALLPATSQEIWRLSWYYLPVVLLSSVMLLVCALLFNNLHRRYPAFWIAPAPPKPAVSPAPVPAPVDVSLEEEKAVKSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJA1</accession>
    <name>A0A0G4PJA1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S017g000246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793150">
        <property type="protein sequence ID" value="CRL26263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJA1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL26263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="59" mass="6891" checksum="18E0A0E5F3A9BD46" modified="2015-09-16" version="1">MSQAGISCSHRQLSDPWTRGPVDPPWTINPNRQKKKKEEEDVIPSSTSPRWPSDRELWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PLD2</accession>
    <name>A0A0G4PLD2_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S021g000094</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S021g000071</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793154">
        <property type="protein sequence ID" value="CRL27156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PLU4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PLU4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="199"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="571"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="5">
        <location>
            <begin position="691"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL27156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1055" mass="117991" checksum="64FFD48963BE769F" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PM68</accession>
    <name>A0A0G4PM68_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S022g000109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793155">
        <property type="protein sequence ID" value="CRL27429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PM68"/>
    <dbReference type="STRING" id="1429867.A0A0G4PM68"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046366">
        <property type="entry name" value="MPAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36124">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36124:SF1">
        <property type="entry name" value="ER-BOUND OXYGENASE MPAB_MPAB'_RUBBER OXYGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL27429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="427" mass="49352" checksum="B92C0451C29B7909" modified="2015-09-16" version="1">MALPPISSIKDAPLFSPFLQASPYQQILCVLLGLATYLALVSSLRFQRRQTLHNKYGYYGTRQSMRSMTDQDAWAIQKAIMQTEFPFIVLKSLQFALFRTYGIPTISTLLLKTSQLSDSATSFKRYADTGTLIGEFMAFDPRSERAQTAIARTNFLHKGYRVSGKILEADMLYTLSLFALEPIRFVKQFEWREMTEMERCAIGTYWKSLGDALGISHDALPSGKTGFQDGIHWLEEIGAWSEQYEVQHMQPHPRNKEIAEKTIDVLVYNVPGFLKPLGGYFVSYLMGDRLRTAMMMEEPPVFFSGILTLTFKLRQLYLRYLSLPRPNFMRLDVFTDKPNKHGRNWVLIYEGAPFYVQPTVWNRWGPMAWFKWVLGRPLPGDDGDKYYPQGYHTHDLGPKYFEGKGYKELEGFKETLRQQRMGQCPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PM92</accession>
    <name>A0A0G4PM92_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S021g000213</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793154">
        <property type="protein sequence ID" value="CRL27298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PM92"/>
    <dbReference type="STRING" id="1429867.A0A0G4PM92"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF11">
        <property type="entry name" value="ISOFLAVONE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G12510)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL27298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="318" mass="34531" checksum="85F9F71F68122DAA" modified="2015-09-16" version="1">MSLAKNILLFGATGNIGSFILDAILPERSQFGRIAIFTSPHTAETKVSQLNKLKEQGVEVIVGNVEDENAVKAAYEGIDTVISALGRNTLAQQIPLIRLAAASPTVKWFLPSEYGTDIKYGLASANEKPHQLKLKVRAYLENEISRDDLAYSYVVTGPFAEMYLHLVPGLEEAGGWDVKGRRAILLGEKGKGEVSLTTMKDVGTLVLNTLLHATAETRNAALCVNSFTTSPDQIQAEFERQLGGQPWDVSRTSLEKLREAEAAAWEAGNPAATVLTLRRIWGEGGTLYAKRANGLIGEPKVMGLEDVVANEIQRVSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNL6</accession>
    <name>A0A0G4PNL6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Deoxyhypusine synthase</fullName>
            <ecNumber evidence="6">2.5.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S025g000017</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine</text>
            <dbReference type="Rhea" id="RHEA:33299"/>
            <dbReference type="Rhea" id="RHEA-COMP:10143"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57484"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="EC" id="2.5.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.46" evidence="6"/>
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</entry>
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    <accession>A0A0G4PNU3</accession>
    <name>A0A0G4PNU3_PENC3</name>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </location>
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</entry>
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        </submittedName>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Dupont J."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL28542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="101" mass="12274" checksum="EDEA01148448E325" modified="2015-09-16" version="1">MRSRYHPYPEERWYQTPLSLLSRDEWVASRVWRYYIQILHYLHITIFARPSTKPYDHFPSDTFLRPNGAGEGIAAPFWALFSYIFIFAWNFEFPIPTERLL</sequence>
</entry>
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    <accession>A0A0G4PQ78</accession>
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        </submittedName>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ceppi M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <location>
            <begin position="48"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL28544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="520" mass="58801" checksum="7B3ACA469D891CD5" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQY9</accession>
    <name>A0A0G4PQY9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
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            <begin position="175"/>
            <end position="204"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        </source>
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    <sequence length="303" mass="33767" checksum="51F3CB98BE9CD9A6" modified="2015-09-16" version="1">MSNVDEDIGHTVVHFLYTGGYETVSSPLGEGTSDLAREYKRSVLVYHASRTWGLTNLEVLAQQKMQHLDEELPILEILRVVRGVFSSLPPGEAWLPGYIQGNLQHLLKPNDPGLGLREFYDIIGQDHEFDNAVMKMVLEILSLRICSMKDQHVKTPNGIISNKSHLSGLVHEEPEPVPEEPEPVPEEPEPVPEEPEPVPEETEPVPEGLSIDSDGRLWTIPRVPAEVDDWPRASSLRGATPNAEILQESIDQGHITRISCSDLTLYENWESLSSKRRAKRASKLRSRGLPVPSETGFISIVAV</sequence>
</entry>
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    </organism>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="31"/>
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        <location>
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            <end position="209"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL28621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="548" mass="60880" checksum="156D20F18C367483" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRN2</accession>
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    <protein>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S030g000063</name>
    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
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            <taxon>Fungi</taxon>
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            <taxon>Eurotiomycetes</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793163">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL28776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="80" mass="9040" checksum="3469D0E1C6A70784" modified="2015-09-16" version="1">MLNPDVASLPAMTSGYWDRAQIALRPVWVNEERTEMQVAFHWLPLKEDMPGAEKHHRGDTVPIMENPYADVAAMSLYGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRP8</accession>
    <name>A0A0G4PRP8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S033g000012</name>
    </gene>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793166">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF23">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="84"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="182"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="245"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="352"/>
        </location>
    </feature>
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        <location>
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            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="30"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL29092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="527" mass="56247" checksum="33B559BBD4C8BAFE" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRU1</accession>
    <name>A0A0G4PRU1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S033g000070</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793166">
        <property type="protein sequence ID" value="CRL29150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PRU1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF12">
        <property type="entry name" value="TRANSCRIPTION FACTOR ASQA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="675"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="687"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL29150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="799" mass="89571" checksum="407468DB66CBDC1A" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRX2</accession>
    <name>A0A0G4PRX2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ureidoglycolate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S031g000046</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(S)-ureidoglycolate = urea + glyoxylate</text>
            <dbReference type="Rhea" id="RHEA:11304"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57296"/>
            <dbReference type="EC" id="4.3.2.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <dbReference type="EMBL" id="HG793164">
        <property type="protein sequence ID" value="CRL28878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PRX2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PRX2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004848">
        <property type="term" value="F:ureidoglycolate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050385">
        <property type="term" value="F:ureidoglycolate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20298">
        <property type="entry name" value="cupin_UAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.480:FF:000002">
        <property type="entry name" value="Probable ureidoglycolate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.480">
        <property type="entry name" value="Ureidoglycolate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047233">
        <property type="entry name" value="UAH_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007247">
        <property type="entry name" value="Ureidogly_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024060">
        <property type="entry name" value="Ureidoglycolate_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21221">
        <property type="entry name" value="UREIDOGLYCOLATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21221:SF1">
        <property type="entry name" value="UREIDOGLYCOLATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04115">
        <property type="entry name" value="Ureidogly_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL28878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="262" mass="28302" checksum="6927080F003EA931" modified="2015-09-16" version="1">MAPILSTTPTVTLTPEPLTPANFAQFGTAVVSPLPRELNIAPQPSSLLPHNPTPVLANQNSALKYSPISPLLDRYTNACPSGQASEARMTMFCCFPRALRAVSTGPQLPDREVFDVRILERHPFTNQTFIPVDLSAHSKVGDDEEEPLFLVVVAPTLKGQTATAKNEAGETITIRDPPDLNNIKAFVARGGQAVTYGVGTWHAPMVVLGRRRVDFVVVQFVNGIGDEDCQEAAFGEGVVVDLGRKGQLGRVENGPRLWSPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PS36</accession>
    <name>A0A0G4PS36_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1993 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S031g000116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793164">
        <property type="protein sequence ID" value="CRL28948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PS36"/>
    <dbReference type="STRING" id="1429867.A0A0G4PS36"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="entry name" value="dinb family like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018531">
        <property type="entry name" value="DUF1993"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36922">
        <property type="entry name" value="BLL2446 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36922:SF1">
        <property type="entry name" value="DUF1993 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09351">
        <property type="entry name" value="DUF1993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="DinB/YfiT-like putative metalloenzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL28948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="19304" checksum="7116187C0D55935A" modified="2015-09-16" version="1">MASPFYNYTIATLTRGLNTLSTLLKKGEEYAKENNIPLDELLNARLVEDMKPLSFQIVTATNAVSKALARAAFVEPPPQQEPDTTYEDLYRRLDRTLAELEEVDPAKIAMKEGQAFKAPIGMKVFNLTLEDYSVRFLIPNFYFHVVTAYEILRVKGVQIGKLDYLSEFMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PS51</accession>
    <name>A0A0G4PS51_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Condensation domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S031g000094</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793164">
        <property type="protein sequence ID" value="CRL28926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PS51"/>
    <dbReference type="STRING" id="1429867.A0A0G4PS51"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF3">
        <property type="entry name" value="SIDEROPHORE SYNTHETASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="3">
        <location>
            <begin position="5"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL28926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="128" mass="14412" checksum="E21BC9FDAFFBE1F1" modified="2015-09-16" version="1">MPMGKPLARFALVEEAEMSYVVLMFHHALYDGSSIPLLMQQVKAAYQGRTVRVEPFTGFIRYCLSLDTDAAQRFWASEFSNLKAVPFPDPRNTTTSSKIEERITVKKEITIPPLAHANITLVNIIQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PS82</accession>
    <name>A0A0G4PS82_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-directed DNA polymerase (Reverse transcriptase), related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S031g000129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793164">
        <property type="protein sequence ID" value="CRL28961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PS82"/>
    <dbReference type="STRING" id="1429867.A0A0G4PS82"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL28961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="440" mass="48830" checksum="0F5CEB4720C39088" modified="2015-09-16" version="1">MKARGIPEDLLRWVEAFCSERTANIQINGQLSEVQSLPQAGLPQGSPLSPILFLFFNADLVQRQIDSQGGAVAFVDDFTAWVTGSTAQSNREGIEAIINEALDWERRSGATFEAEKTAIIHFAPKTRKSDHDPFTIKGQTVVPQDHVKILGLLMDTRLKYKKHIARAASKGLEAAMELRRLRGLTPAAARQLFTSTVAPVVDYASNVWMHACKDKAMGPINRVQRVGAQAIVGIFLTVATSVAEAEAYIATAQHRFWRRAAKMWTDIHTLPETNPLRRNTDRIRKFRRYHRSPLYQVADALKHIDMETLETINPFTLAPWEARVQAGVEATPQSPIVLGGLMQIATSSSARNELVGFGVAIERQPPRYRKLRLKTLSVTLGARAEQNPFSAELAAMAHALNIVVGVKDYRITLLTSNKAAALTLRNPRQQSDQCPVDLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PSS4</accession>
    <name>A0A0G4PSS4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S035g000105</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="HG793168">
        <property type="protein sequence ID" value="CRL29410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PSS4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PSS4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045025">
        <property type="term" value="C:mitochondrial degradosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000965">
        <property type="term" value="P:mitochondrial RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17913">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18805">
        <property type="entry name" value="SF2_C_suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000269">
        <property type="entry name" value="ATP-dependent RNA helicase SUPV3L1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.40:FF:000002">
        <property type="entry name" value="ATP-dependent RNA helicase SUV3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000957">
        <property type="entry name" value="ATP-dependent RNA helicase SUV3L, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055206">
        <property type="entry name" value="DEXQc_SUV3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022192">
        <property type="entry name" value="SUV3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044774">
        <property type="entry name" value="Suv3_DEXQc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22527">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12513">
        <property type="entry name" value="SUV3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="343"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="32"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="716"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="745"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="762"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL29410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="776" mass="86300" checksum="D93E41205228E719" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PTD3</accession>
    <name>A0A0G4PTD3_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cofilin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Actin-depolymerizing factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S038g000070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
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        <property type="protein sequence ID" value="CRL29667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PTD3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PTD3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11286">
        <property type="entry name" value="ADF_cofilin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="6">
        <location>
            <begin position="17"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL29667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="163" mass="18664" checksum="C98BE1F9FAC17BF6" modified="2015-09-16" version="1">MKNASSVNLSILLQLETCRVSIADDCITAFRELRSQKSSKKPRFIIYKITDDYNDVIVEESSSVQDYEVFRQKLVSAVDTEGNPAPRYAVYDVEYDLGLEGKRSKIVFITWVPRETSTKVRMIYASTKEQLRRFLDTKASIHADDPDELEWKTVLKEASDGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PTM0</accession>
    <name>A0A0G4PTM0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S036g000077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793169">
        <property type="protein sequence ID" value="CRL29493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PTM0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL29493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="135" mass="14299" checksum="ABD3C84DAC83FCBA" modified="2015-09-16" version="1">MSWPSSGQDYSSGDDTIIGFTRGPPAIMQHGITFSVSVMVKFGESSGLSLVPTQAFAVNVSLVDEYGTRTSGVLQGNLTSNIQFHPTQGAHGFAVFGGLSICQTGLWRLRVLLGAFSCAEMAIEARVDSIVFHVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PTR7</accession>
    <name>A0A0G4PTR7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S041g000007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793174">
        <property type="protein sequence ID" value="CRL29865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PTR7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL29865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="287" mass="32435" checksum="FB4648912F07B2F1" modified="2015-09-16" version="1">MAGIVNGPLSLFRKSDSSKPLHARWGDASISVPTDGSWNQYDNPHRPAKERSAYGPGYVPDCSPQDRRNPRPVKEEDQDDDARSVCSEASTVSRRSSLSLGSLRPGRLSVRLASRPKQLRGESQTERDARRSEQKRNEFAYRPIQHDYTSEVVENNTHPNNRFKYIPTNGRYLQSSGAEIPRSQSVNSPRSPHSRRGSLSESSDRRDSGRDRDHYIPTVRGSTYQEDDRRSLHSTSFRDSSDGSRWNYGLPPRRRTSPFVAADSKRASSVSRPMTVAMVPDPDDLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PTW8</accession>
    <name>A0A0G4PTW8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S040g000027</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793173">
        <property type="protein sequence ID" value="CRL29801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PTW8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PTW8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF14">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="49"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL29801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="359" mass="40467" checksum="CE6D1DF20D436984" modified="2015-09-16" version="1">MWDRSKMTSAIPDSNSSSSPRGHSQSERDSPNRKKRKGPRLAHRKSRTGCQRCRARRVKCDESRPVCRDCHRHGIPCVYDRAAEEGATPPSTGIQSRPLEPSPSDPGNDAHMELRLMHHFTLFTSATMPGAHLKRIKDCWSIDVPRLAFSYKPLLHAIFAISALHMSKANLDEVGLPDIHCNFLEQAMREHRLCIGGITTQTADAVCFTSILLQIDVFATLQNRHVVSYEQVSEWMRLVRGSVAVFDAALEIARHNTHPPNIWCIIDTFPMPLRTNSDVGSFSFLLSTVPDDEDDETALEAYRGAVAHINATWLAMEAKEHPQISCRRLMVFPLFATAEFIDLLEKRRPRALTLHTNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUF4</accession>
    <name>A0A0G4PUF4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S040g000025</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793173">
        <property type="protein sequence ID" value="CRL29799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PUF4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PUF4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF17">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195750" evidence="9">
        <location>
            <begin position="20"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL29799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="488" mass="54836" checksum="EB95503CA7020112" modified="2015-09-16" version="1">MHTALCLAVFTVLFHYTITERPWHILGLVKIYSSTKHLLNETALSNVSALFECYGDTYASRILTQRVYFTRDPQNIRHVLINRFSDFDASDVRAHLFAPITPHGIFAVDGAEWKGARSMYADIFSATRKIFDLQLQEDGFQGLIKQIPRGQAMDLAPLFLKLVLDVNSAFAMGTGLDTLKQDQSQEKKEVAEALMCAKKIMARDGFLGPLHYLLSRKDFYAACETVKAYVEKVVRKEMAAREYQKQSNAATVDDEGQKGTQSLLSRILDNTNDVHAVRDAVVTILIAGTDSVASMLSTTFYLLARHEHVYAKLRQEILDTIGTEPPTYDNIRKATYLRHVFNEAMRVYPPVPFNARTANRDTYLPAGGGPDGQSGVLIRKGQRVIFASWGSHRSTRSFGADALEFRPERWEGLKSESLGYIPFSAGPRVCLGPVARVVEQYALLEASYATIRIIQTFDRLENRDVRPWTEKIGLNLSNKNGVLVELVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUW5</accession>
    <name>A0A0G4PUW5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S048g000027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793181">
        <property type="protein sequence ID" value="CRL30315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PUW5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PUW5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="345" mass="39749" checksum="702ABE721F7B64F3" modified="2015-09-16" version="1">MYPSEITSQSIPLNNNTLQRTEFSVERIIDGELDKTICFEVYQGHLYVVLIIDDRESSFYHWSCYAPNCGSKKGNGRLWRRDHREGPIHEMWADLSIQVDEKKGRPVILECRREWLDGGSENHRTYYTTPLPTPDEALAMQSAEGLTHQGGLVDSDDEHRQSSEKRLARDCHAEHETSDPLDQRRDFIPAYTRHSSYHLAAATYIDLVNDPKSQADGVHFQHCLRLRTKSRNRDRSDERGWDDIAVRCQTQGNKSTSLVRAVCDERSLIYSTSAEGLPPHHHMLVLISFDPMIRLPYLISLRNQKASTNSTRKVLDAPRPDFQFSRPLVHNADAFHLVIRQGYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVY4</accession>
    <name>A0A0G4PVY4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S056g000044</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793189">
        <property type="protein sequence ID" value="CRL30671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PVY4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PVY4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL30671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="157" mass="17936" checksum="FDC3FA40CF09B404" modified="2015-09-16" version="1">MRISSLPINLLVCICSYLVNRGIKSLRLTCEHLARNGLVCLNRVFLTASPYNIRVLRAIADHEGFRRDVTEIIWDDARLVDAPKLYRDLVWEFDDAEIDPDGGCPNWFVAVCKENLESVDERKIAGIDRPDHVAGGKQDIAQPLEVCWQLYQNLLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PW16</accession>
    <name>A0A0G4PW16_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S053g000039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793186">
        <property type="protein sequence ID" value="CRL30531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PW16"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="170" mass="18514" checksum="34080CCB8C17983D" modified="2015-09-16" version="1">MGGIRKVSHTHRGLNFRSRLQRALSLSSSESEKTSTPSASETGDTTEEEGLQDGNDCPDDQENCDPADENEEASREQRKKRNHEKGLEIPEQTQLQGEGNAVGLECVAESIESLSYVQSTCNETVRNDLADIFARLAIVETEIKKMAKHGGNKATGGQKPGRSLRRGNSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PWC0</accession>
    <name>A0A0G4PWC0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S052g000021</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793185">
        <property type="protein sequence ID" value="CRL30464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PWC0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000386">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF39">
        <property type="entry name" value="TRANSPORTER LIZ1_SEO1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="437"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="79"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL30464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="512" mass="57788" checksum="2358AEF18B7ED780" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PWG8</accession>
    <name>A0A0G4PWG8_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S052g000034</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="HG793185">
        <property type="protein sequence ID" value="CRL30477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PWG8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18044">
        <property type="entry name" value="DEXXQc_SMUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.270:FF:000006">
        <property type="entry name" value="Similar to DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048761">
        <property type="entry name" value="SMUBP-2_HCS1_1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21138">
        <property type="entry name" value="SMUBP-2_HCS1_1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="231"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="249"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="453"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CRL30477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="715" mass="78552" checksum="B47A92E7D754799B" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PWM1</accession>
    <name>A0A0G4PWM1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S060g000015</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">FM 013</strain>
        </source>
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        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
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        </reaction>
    </comment>
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        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR051346">
        <property type="entry name" value="OTU_Deubiquitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367:SF34">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367">
        <property type="entry name" value="UBIQUITIN THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12340">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
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        <location>
            <begin position="18"/>
            <end position="304"/>
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            <end position="218"/>
        </location>
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            <end position="2902"/>
        </location>
    </feature>
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        <source>
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        <source>
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        </source>
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    </evidence>
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        </source>
    </evidence>
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</entry>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
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    </evidence>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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                <person name="Silar P."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF5">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PXB4</accession>
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        <submittedName>
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        </submittedName>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Dupont J."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793193">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PXB4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF2">
        <property type="entry name" value="LYTIC POLYSACCHARIDE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195693" evidence="2">
        <location>
            <begin position="20"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL30809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="284" mass="30890" checksum="A8B6B764D268FCF5" modified="2015-09-16" version="1">MLLKYILLLETIVLRAVSGHLIMISPEPYSNETLNNSPLAENGSDFPCKLGTDAFLASSTETIYQIGIENTMKFEGSATHGGGSCQLSLTEDREPTKDSEWKVSKSYEGGCPANAERNFAGGATADNDLQLDFAIPENIQPGKYTLAWTWFNRIGNREMYMNCAPITVASGSSQQSYKSIQKQTPNFPPMFIANINGCITKENVDIRFPQPGSIVEHNGQLNNLLREGGQPCTGTPTFSALAAIRSTIPDFAEGVLGETVSSSTSSAFARTSSRGALRRNYDHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PXB7</accession>
    <name>A0A0G4PXB7_PENC3</name>
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        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">PCAMFM013_S065g000008</name>
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        <lineage>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793198">
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    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PXB7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021842">
        <property type="entry name" value="DUF3435"/>
    </dbReference>
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        <property type="entry name" value="DUF3435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL30958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="37" mass="4088" checksum="AED0A7D156D7EF5A" modified="2015-09-16" version="1">MKCGGEITGFAEVAKLYYLRYSAVKAFNDSPDVSNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PY28</accession>
    <name>A0A0G4PY28_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S074g000001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PY28"/>
    <dbReference type="STRING" id="1429867.A0A0G4PY28"/>
    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF34">
        <property type="entry name" value="OS04G0183300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL31086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="285" mass="31822" checksum="FC29DE96ED231C15" modified="2015-09-16" version="1">MAGRSEYDEMTWNIPRDQALDYVKFCKGTDLSGISIGIPRNTFEVDNDYPVSAAFEIALQSLSSAGATIVDNTDFPAAEEFTKLNEQVKGIVRSSEFRRDFSRYIQTLETNPNNIGSTEDLIEFTKTHPEEEYPERDIGKFLWTQAEGIDVDSDKYTEMVQQERYFGGLGGILGAMEKYNVDLFAVPSYWGIANDLAAKMGFPVISIPLGYFPEGTPIEYDQGLVVQAPGMPFALTLLTKAFSDGVLLEVAYAFEQLNSVRNREPAPIKLPVTELRDVQHQVGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PYZ2</accession>
    <name>A0A0G4PYZ2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S3Jg000002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793312">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PYZ2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL31392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="154" mass="17435" checksum="2248B6D1AB26D1AD" modified="2015-09-16" version="1">MSCNPAHLQWILGQVLGDPLHRERCIWAGDDGNHCQNTVPLDSRINGVVCFQLLRGSLLVYPLAQEISSAAKQLLCLECRRHRSRSRVWATRFLRQLDQATDVTVHSEPHDSALLVHQWPTSMSHNVATAVCPNESFSKPEEAAWRRNQLATYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NSM2</accession>
    <name>A0A0G4NSM2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S001g000028</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NSM2"/>
    <dbReference type="STRING" id="1429867.A0A0G4NSM2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL17068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="472" mass="53539" checksum="CC42D1CAD2D6C623" modified="2015-09-16" version="1">MVGVPRSNGCSLCVKRRVKCDQRLPGCAKCDKYGQPCPGYDRGFKFITGKPYRDRRQPNPKNDKKDGARSKSATSNSMVDLAPTCQTMAQREKPFSVISVNLNIVQHLCVLIDDFSQPYTPSPTHVVVRWFGFLPSIYGQNRVLDATIRSFTAHNFGRTTKNTQMVSYARSAYGEALRGLRKSLETPAESLSSHIFCAVVLLCMYELFTDTENPESWMKHAKGLSQLVQIRGPERYNTELDITLLKAARGLIVMHSMFSGEECFLASDKWHDKMRQQYTSDLPPEVHSSIELFFAYFTYAPSLVHKLYGLRNVDVTGAEALQTISEVQSKALEMQINLAIWYEQFSQIVPPPTETISSTGDELYPIILIYTDVSYATIYCGYYSYMVIIHEILKTCGYPGEHEAMVAYFRDQICKSVEYNSVGVMGPYRMGFPLRVAFEIADPVTRSWILNRLEQFSNIYAAAQPENYHTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NTE0</accession>
    <name>A0A0G4NTE0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rap1-interacting factor 1 N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S001g000317</name>
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    <organism evidence="9 10">
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</entry>
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</entry>
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    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL17559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="368" mass="41128" checksum="4337EC367902076C" modified="2015-09-16" version="1">MAANTDERDQTRDEIAQQLSPTPFACSSLTRLSGGTANFVYRGTLSSTGQSVVIKHTKDHSASNPDFKIDVTRCHFEEAILQALDGLATYTNGKITVKTPRLLDFNRETNTQVFEDLPNSIDLKNFLLSKVSHDLSESSGRALGGGLGSWLRSFHHWTAEEQQIESTKILGENKVMKDLKFWVNYTLLLDTIENFPDILEGNRDIFEKVRGLAAAELEQQSHDNGHGVIHGDFWTGNVLLPNVPLTDQSPTTMFIVDWEMSQIGSRALDLGQMIAELYETKLFKNVDGGVWIIQGFLEGYGALEDEMAFRTAIHVGVHLICWGSRVPGWGTQKQIEEVVELGRDLIVHGWRKDKAWFAEGTLSCLFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NVK4</accession>
    <name>A0A0G4NVK4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tafazzin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S001g001042</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a cardiolipin + a 1-acyl-sn-glycero-3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:33731"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="ChEBI" id="CHEBI:62237"/>
            <dbReference type="ChEBI" id="CHEBI:64743"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:33732"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:33733"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the taffazin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL18082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NVK4"/>
    <dbReference type="STRING" id="1429867.A0A0G4NVK4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000872">
        <property type="entry name" value="Tafazzin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497:SF0">
        <property type="entry name" value="TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497">
        <property type="entry name" value="TAZ PROTEIN TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="13">
        <location>
            <begin position="64"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CRL18082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="374" mass="42688" checksum="12463F6C16B6E197" modified="2015-09-16" version="1">MDSSATAESPSLPWRALSNTTMWGVAGLCRGFLSVFCHAECHGKEAFTELLDSRHDVSQRTRGLITVSNHISVMDDPLLWGILPPRFWNKRWSFGSYDICYQTRPLSLFFTMGQVLPTHRSAHSTFGGLAQPAMTEAIRLLSKGPFPVDHHRAAPERQHWSWHNVCVDPFSDLSVAYTTDGKDSHLAPTAYSCNSNSWVHIFPEGKIHQSPRKTMRYFKWGIARLILEPKECPDVVPMWIEGFDNVMHESREFPRFLPRPGKDVSVTFGSKVDSDAVFGEMRSRWQKLKAKVEKTYPDSRDLPLGVLSDELLNDKEAVELRKEVTLKIRNLVLDVRRSRGLPDEDPKEGLVDTWLEEGAKREGHMKDDSWVRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NW36</accession>
    <name>A0A0G4NW36_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S002g000054</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NW36"/>
    <dbReference type="STRING" id="1429867.A0A0G4NW36"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02657">
        <property type="entry name" value="Peptidase_C19A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16104">
        <property type="entry name" value="Ubl_USP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF1">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="4"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="111"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="396"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL18184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="577" mass="64671" checksum="5EB6C34A41084596" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWF5</accession>
    <name>A0A0G4NWF5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alcohol dehydrogenase superfamily, zinc-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S002g000278</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWF5"/>
    <dbReference type="STRING" id="1429867.A0A0G4NWF5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF2">
        <property type="entry name" value="DEHYDROGENASE FAMILY OXIDOREDUCTASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="19"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL18408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="356" mass="38055" checksum="285FB8631330AC2C" modified="2015-09-16" version="1">MSIPPIPRIQIAAVIASTSNPVSAKVGIKSNRPVPTPGKGEILVKLEFSGVCHSDLHSIRGDTPMLTDVAGHEGVGRVVKVGPEVDEKQWIGTRVGIRWLYSSCRQCEICEINHTVCPYQKNAGANVPGTFQQYIVSPALHVTKIPEQLSPDSAAPLLCAGIAMYSSIMKTKTRPGDYLAILGAGGGLGHMGIQIAAKKGLKVIAIDSGDKKKQLCLSLGATEFLDYREVDIVQAVKAKTTFGVHAVICTANGERAYEQSMQMLRPFGTLVCVGIPNKPFKLPATPFDMIVKGLTIVGNSAGTADEMDEMMAMAVAGDVKAHIDVFGLDDINDVLDRLERSEIDGRVVLRIPQSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWG9</accession>
    <name>A0A0G4NWG9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF1907 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S002g000337</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWG9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17298">
        <property type="entry name" value="DUF1907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015021">
        <property type="entry name" value="C11orf54_DUF1907"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13204:SF1">
        <property type="entry name" value="ESTER HYDROLASE C11ORF54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13204">
        <property type="entry name" value="PTD012 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08925">
        <property type="entry name" value="DUF1907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01168">
        <property type="entry name" value="DUF1907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117856">
        <property type="entry name" value="AF0104/ALDC/Ptd012-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DUF1907" evidence="7">
        <location>
            <begin position="19"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL18467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="326" mass="35807" checksum="7684ADA45E98FD0A" modified="2015-09-16" version="1">MAVTKHLRDPPPLEELAAVIEKALLSNFKTASATVAECPDLKQPPFHLAASGLSGSPRIADIGGQQHLFPRPILNAKYSLLSLAQDMEMSPMAGFLLGAGAAPFQDIGQNAELAPNLSWRSSEKAPSFDEPSLLTFDNGTRVIKVQGDRDQTPVCDRTSSTNCALMVNLFGSDGDTGPVLKINAKARKGEENFTDCIRYGLQKVYGDSKPISLGGVFLLKSGKARFHIMPDFPPEDQLPYRDRKQLETEWLSYHIFQAPIVCLTVMHSSDPEGLGLRMEHTHCFGVNGNPKGGHYHYDIQDGDEEVEYEAYFNVASVVYRVDRPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWQ9</accession>
    <name>A0A0G4NWQ9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S002g000355</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWQ9"/>
    <dbReference type="STRING" id="1429867.A0A0G4NWQ9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF14">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL18485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="551" mass="61599" checksum="323637C0D0E3B9FE" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXF0</accession>
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        <submittedName>
            <fullName evidence="8">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
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        <name evidence="8" type="ORF">PCAMFM013_S002g000484</name>
    </gene>
    <organism evidence="8 9">
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052761">
        <property type="entry name" value="Fungal_Detox/Toxin_TFs"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
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    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </feature>
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            <end position="124"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL18614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="674" mass="76598" checksum="EC917F75BE41B6F0" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NY24</accession>
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        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">PCAMFM013_S002g000862</name>
    </gene>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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            <taxon>Pezizomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
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                <person name="Silar P."/>
                <person name="Lacoste S."/>
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                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
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    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
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        <location>
            <begin position="151"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL18992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="334" mass="34833" checksum="13D73E52A1CBD014" modified="2015-09-16" version="1">MDDFKVVSDLRKSTMSYGGLELVSDLKRWPKSYDGLEVRVEQEKEVPITRGGLYYVSSPERPGSSIPDDDLAKADGPKAAKRVCGVRPTVFWLLLVIAVLIVVIAAVGGGIGGSYLANRGKSDSDPATSGSNTTPAMFVVTRTYDGDSFTTTLEPTTDSAMPITSSISDTSPHSTISGSSDDSTISITTATSSHSETSAVTSASKTSSAAVTSGTSGIASNPCPAQNLTTVTGSDGSIFTLLCAVDWPSGIKTAYGNGKVGDLTRFTEYTLKSCISQCVEWNTENDEKCKGVIYSANLTASYDGGQEGNCFLKNSVGKYYPNSGTSMAAGILGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYD5</accession>
    <name>A0A0G4NYD5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
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        <name evidence="10" type="ORF">PCAMFM013_S002g000941</name>
    </gene>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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                <person name="Giraud T."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CRL19071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NYD5"/>
    <dbReference type="STRING" id="1429867.A0A0G4NYD5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AUSG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL19071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="282" mass="31697" checksum="EF6810B1E37B5EB2" modified="2015-09-16" version="1">MIDHRLSLNDFGPGGLALLTLSAFLLFWVLGPRRSEKAPFVDGRKSGEFFHIGSQRRFANHGADIVKAAQSRVAQAFYIITSSGRKLVLSGEYADELRSHPHLSHGQSLENNMSTNLPGFEPLSNGRRHGPITNDIVMKLTRALARVTKPVSEESALTLLESWTDQRDWHDVSLHETIYRMIAQVSARVFVGKELCRNPAWGIATANYTGLAFVALNEVQKWPRSLQRIVHWVLPSARAMRAGVREVRALLTPIVERRRVERARQAQQGTPTDVEEEFSLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYR4</accession>
    <name>A0A0G4NYR4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid/polyamine transporter I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S003g000018</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NYR4"/>
    <dbReference type="STRING" id="1429867.A0A0G4NYR4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004762">
        <property type="entry name" value="Amino_acid_permease_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00913">
        <property type="entry name" value="2A0310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF4">
        <property type="entry name" value="ARGININE PERMEASE CAN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="470"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="31"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL19227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="510" mass="55778" checksum="3D1F2EC99E37C1E1" modified="2015-09-16" version="1">MADDIEGNQEKHSNGESPQLPELQRRLKSRHLQMIAMGGAIGTGLFIGSGSAIATAGPVGALIAFTFIGSIVYSVMIALGEVATYLPIPGAFATYATRLVDPSLGFAMGWIYWFSWASTFALELTATGLIIQYWDDTIPMAIFIAVFWVVIIILNMFPVSCYGEVEFWLSSIKIITVVGFMIFAICVNAGVGREGYLGFRYWVHPGPFRPYLIEDSGQDALAKFVGFWAILIKAGFSYQGTELVGIAAGETENPRKNIPSAIRKTFFRIVFFFVFTIFFVGIVVPSNDERLTDNDSGANADASPFVIAAKRAGVNVLPSIINAVLLTVVLSAANSNVYSGSRILVGLAHEGFAPRFFLKTTKHGVPYGSVGFTALFGLLGFLNVSNAGATVFNWLMQIAGLAGFITWASLNICHLAFMRALAAQGVSRDTLPYTAPWQPFFSWYGLFFNMLIIITQGFTAFIPKFSVTDFFINYLSLILFAVLYIGHKVAFRPTFVKPIEADIDTGRCEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYT5</accession>
    <name>A0A0G4NYT5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S003g000033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NYT5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL19242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="91" mass="10535" checksum="6DD32705421E1FA8" modified="2015-09-16" version="1">MRRFRLSFVRTILYGMRKYIIRPHKRPTILYTVARVVVIYLATDMHSNPTYPAAPFELLDVIQVNIAIISPTAFPIISRVRKAVRVSSIPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYU1</accession>
    <name>A0A0G4NYU1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fructose-2,6-bisphosphate 2-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S002g001034</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.46" evidence="2"/>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL19164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NYU1"/>
    <dbReference type="STRING" id="1429867.A0A0G4NYU1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000005">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000644">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF44">
        <property type="entry name" value="6-PHOSPHOFRUCTO 2-KINASE_FRUCTOSE 2,6-BISPHOSPHATASE LONG FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="9">
        <location>
            <begin position="6"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="421"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="6">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="229"/>
            <end position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL19164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="451" mass="51492" checksum="71C09FA6269E79D7" modified="2015-09-16" version="1">MSAVNFATQSDDSKICVVMVGLPARGKSLIAGKAMRYLGWVGVPARVFNVGSYRRFSTPQPQAAFFDPHNAEGERMRRAAAEAAMSDMLQWFNAGKGVVAILDATNSTKDRRKWIYEKCTEAGIEALFVESICDDEDLIMTNIKEVKTTSPDYKGQDPEVAALDFRNRIRNYEKVYETIDDDEKKYTYVKLINVGSTVIINQIKDYLSSRLVYYIQNIHIKPRSIWLSRHGESEFNLTGRIGGDANISERGEAYARALPELMRKSGIPDNTKIVIWTSTLRRTIQSARHLKAATGYETLEWKALDELDSGVCDGLTYEQIAEKYPEDFAARDEDKYNYRYRGGESYRDVVIRLEPIIMELERSENVIIVTHQAVLRCIYAYFMNIPQEQSPWMEVPLHTLIKLTPRAYGTEEQRFKADIPAVSTWRGKGTSARHQDFPTEGEKKEDTETKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZF8</accession>
    <name>A0A0G4NZF8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S003g000247</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZF8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046925">
        <property type="entry name" value="WD-like_fungi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20493">
        <property type="entry name" value="WD-like_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195270" evidence="1">
        <location>
            <begin position="22"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="WD-like" evidence="2">
        <location>
            <begin position="68"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL19456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="270" mass="29090" checksum="F20A0FFA4495F673" modified="2015-09-16" version="1">MFKGRSICALAITALATTAQCQQLSYEDSVTALAYGNVATDTSAEGTVWLNVTGFAVDKLPHIQEDLGIHTLDNLETLNAIAGLAQDAATKGQWGDIVYLYSAFAMNGHGEYLNVSTVEMQESLLDAITDRDSGEIDHQLAELYASTSSSKFLVDAFHGLKSKTSTPSKRWLREVCSNAHLAVKNSCRSLLENVRGNATWKTGSPRSICKYGCCISWSANATFQVENLTNAANYCINACGTSNVSCEVYGVKLQGTLVDQCLSNRATGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZI7</accession>
    <name>A0A0G4NZI7_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome complex subunit SEM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S003g000264</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DSS1/SEM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZI7"/>
    <dbReference type="STRING" id="1429867.A0A0G4NZI7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13768">
        <property type="entry name" value="DSS1_Sem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007834">
        <property type="entry name" value="DSS1_SEM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771">
        <property type="entry name" value="26 PROTEASOME COMPLEX SUBUNIT DSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771:SF0">
        <property type="entry name" value="26S PROTEASOME COMPLEX SUBUNIT SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05160">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01385">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL19473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="87" mass="9812" checksum="4E426A0C7F42358B" modified="2015-09-16" version="1">MSNPTTQKADATEQAPPQAKPQVLEEDDEFEDFPVEDWPQEEAEQTNGSTANDGSEHLWEESWDDDDAAEDFSKQLQEELKKVEASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZN0</accession>
    <name>A0A0G4NZN0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA/RNA non-specific endonuclease, active site</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S003g000304</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZN0"/>
    <dbReference type="STRING" id="1429867.A0A0G4NZN0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="96"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="129"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="163"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="302"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL19513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="373" mass="41610" checksum="9108649225C0CFDB" modified="2015-09-16" version="1">MVGSSPYITLEIPARLERRDSCHRTCLWHAVSECNESRVKLLLESGQDALAEDCDRVTPLNCAIMRNNASIIRLLLEHLKAIYSKTTFLDDTAISGANLPLCLAAEYNRTQIIDLLLEFGADVNAANRHGNTPLHQAADRGHLAAVGLLLKQQNTNLQARDSSGSTALHISIQQNHISIVMLLLVNPNVDINCKDMHGNTPLWWSTRLERDDISLRLLAEDSVDLNAVGWKSGLFTTPLFHAVARQNCSLVKIFVEKSDLDPNIPGYCGWTPLSHAVRDGNIAIVRLLLWRDDVRCNAAGPDEDSLLLLAAKCGRTKVIDLLLQQGSRIDINYRNNKNDAKLPSEQQLLIPMQWTNLVRLRYSTLAQRSIFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZN5</accession>
    <name>A0A0G4NZN5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S003g000309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL19518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="109" mass="12343" checksum="018751E3BAA760D1" modified="2015-09-16" version="1">MYIYAKPITCTLDDETLRQELGIQGRVAFYDRANPAATLLENGLEQMDPQDVRPPQRLPDTRHRKGRGKGKGASQGQKRAGTTRRRNRRADQFCVHIVANEHHAAQHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
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    </gene>
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Znf_RING"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF3">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="15"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL19632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="103" mass="11966" checksum="89B5F152238A17E3" modified="2015-09-16" version="1">MPCYVGSQYAKDDECSLCFEDMTPDSIFRQLPCRHIFHQPCIDKWLCKRDASCPLCRQTFYHLRPSVFAWKSAAIQSHNGDNVASQSRGTFVHRCKRLLHLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P089</accession>
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        <submittedName>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
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                <person name="Lacoste S."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
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    <dbReference type="STRING" id="1429867.A0A0G4P089"/>
    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL19684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="168" mass="18927" checksum="82A50DD287ACAF15" modified="2015-09-16" version="1">MTPNEHQIHEDLWAFVRTGELKKPYSAYRPAFQLMCGTSFASGIKPGNLPTWLLVTADFSKTISVPKKQPAQEFVESFQRPVRWLLTSSTPSSFGGARTVKQMIIISPYEARCLLLAIRKSTTVTLHQYAPRQSYTFDSLNKLCLPEGTAAIKIPDTLSWEVLAPMYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0K4</accession>
    <name>A0A0G4P0K4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein S12/S23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S003g000633</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS12 family.</text>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Nucleic acid-binding proteins"/>
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    </dbReference>
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        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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        </location>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL19841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="145" mass="15786" checksum="3BB6B7DC45B0318E" modified="2015-09-16" version="1">MGKGQPRGLNAARKLQAHRKDQRWADDHFKKRLLGTAYKSSPFGGASHAKGIVLEKVGVEAKQPNSAIRKCVKVQLIKNGKKVAAFVPNDGCLNFIDENDEVLLAGFGRKGKAKGDIPGVRFKVVKVSGVGLAALWKEKKEKPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0L2</accession>
    <name>A0A0G4P0L2_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit F</fullName>
            <shortName evidence="4">eIF3f</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S003g000648</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit F family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P0L2"/>
    <dbReference type="STRING" id="1429867.A0A0G4P0L2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08064">
        <property type="entry name" value="MPN_eIF3f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000019">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03005">
        <property type="entry name" value="eIF3f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027531">
        <property type="entry name" value="eIF3f"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF6">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="29"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="304"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL19856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="343" mass="37069" checksum="623B3D0D3ACC4C6C" modified="2015-09-16" version="1">MAEDSFLHLARPLGPVSVGTAPTTAPLNVVIQPQAIFSVLDHSLRRNADQERVIGTLLGTRSEDGSEVEVRSAFAVGHSEAEDQVEVDMEYHKQMLALHLKANPREVLVGWYATASELNTFSALIQNFYSGQGDGTWPHPAVHLTVSTEAGKDLETRAYISAPVGVTAERAADSAAFIPVPYELRYGEADKSGLESIANAKDAEDRSTSVTSDIESLERAIEEVLSMVDRVSRYVESVIDEETPASTAMGQFLLNALALAPKVEAADIERDFNNHIQDVLVVSYLANTVRTQMELSTRLATAQLTLGGGGEGPATGEQRNQRGGKGNQQGGRPRQDRNEEARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0U1</accession>
    <name>A0A0G4P0U1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cell division/GTP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S003g000723</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P0U1"/>
    <dbReference type="STRING" id="1429867.A0A0G4P0U1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032161">
        <property type="term" value="C:cleavage apparatus septin structure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005940">
        <property type="term" value="C:septin ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043934">
        <property type="term" value="P:sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000260">
        <property type="entry name" value="Cell division control 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="7">
        <location>
            <begin position="35"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="312"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL19931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="344" mass="38983" checksum="84A01CB39D22573E" modified="2015-09-16" version="1">MATTAASAQQPTVFPHSHVGFDSITSQIERKLLKRGFQFNVMCVGQTGLGKSTLINTIFASHLIDSKGRLTPSEPVRSTTEIKTESHIIEENGVRLRLNIVDTPGYGDQVNNDRCWDPIVKYIKDQHSAYLRKELTAQRERYIQDTRVHCCLFFIQPSGHALKPIDIVVLKKLSDVVNVVPVIAKSDSLTLEERQAFKERIKEEFSFHNLKMYPYDNDELDDEERAINAQIKDIIPFSVVGSEKTIVVNGKQVRGRQNRWGVINVEDENHCEFVYLRNFLTRTHLQDLVETTSQIHYETFRAKQLLALKESSAAGGHTGGSRPISPSADRELSRNSQRAAMNGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P165</accession>
    <name>A0A0G4P165_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily, general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S003g000816</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL20024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P165"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
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            <end position="275"/>
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            <end position="302"/>
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        <location>
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            <end position="432"/>
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    </feature>
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    </feature>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="558"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="564"/>
            <end position="583"/>
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    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL20024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="614" mass="67362" checksum="169DB25AA68AB2F7" modified="2015-09-16" version="1"> </sequence>
</entry>
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
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            <taxon>Eurotiomycetes</taxon>
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    </organism>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
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                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
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    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4P1X0"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0005762">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013870">
        <property type="entry name" value="Ribosomal_mL54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L54, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08561">
        <property type="entry name" value="Ribosomal_L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="43"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
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            <end position="83"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
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            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033752"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00035179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL20294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="243" mass="26272" checksum="C3178EDBB57EF78B" modified="2015-09-16" version="1">MICKSCRTTMLSRFNQQPVIRTASACARQLPLVRSQFRLYSSDNNSPVAATPSPPSPRQPTVGDLTTPSAVSSATPGVSQPLSTPEGVHTDANPGAATKPTAVRPPSSCPAGTKLNGLNYFKNKPDVFAKEDSEYPDWLWNLLGDATKDAKTKQGGVDPSTLNKKQRKRYEKKLAARTGPLAAKIPAHHHAHDITPAPYNRDAPSADAMADATEGFEQRSEIIKSARDARRKAIKESNFLRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P233</accession>
    <name>A0A0G4P233_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Chitin synthase</fullName>
            <ecNumber evidence="2 11">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S004g000326</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cell membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the chitin synthase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 11"/>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P233"/>
    <dbReference type="STRING" id="1429867.A0A0G4P233"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF9">
        <property type="entry name" value="CHITIN SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="561"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="601"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="636"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="670"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="714"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="843"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="883"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="13">
        <location>
            <begin position="174"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CRL20386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="915" mass="103678" checksum="013266F830BC501F" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P273</accession>
    <name>A0A0G4P273_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sugar/inositol transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S004g000360</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P273"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF78">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="23"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL20420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="567" mass="62012" checksum="5DCC8292CA7EC35E" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P279</accession>
    <name>A0A0G4P279_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S004g000354</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P279"/>
    <dbReference type="STRING" id="1429867.A0A0G4P279"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL20414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="73" mass="7949" checksum="D8CC1D8A277BAA4B" modified="2015-09-16" version="1">MATALRSRVFFDIKIGDGEPHRVAFELFNDVVPKTADNFRALCTGEKGIGTQGKELTYKGMSAIPRSHGADAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2I4</accession>
    <name>A0A0G4P2I4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alcohol dehydrogenase superfamily, zinc-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S004g000471</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P2I4"/>
    <dbReference type="STRING" id="1429867.A0A0G4P2I4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF42">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, ZINC-CONTAINING (AFU_ORTHOLOGUE AFUA_7G04530)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="24"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL20530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="347" mass="37546" checksum="AD18FD398AA50C25" modified="2015-09-16" version="1">MSSAPTEHTAIHLQQRPETDIIPGETFAAQKHTTPTAADLQDGDVILETLYLSLDPAMRGWLDDVPSYLPPVAIGEIMRGHALGRVTASRSQKFPVGSYAIGIVGWTEQAIVNENSLDAVPAPDPANGGRLTDHMSVLGMTGVTAYWGMVEVGRVKPGDFVVVSGAAGATGSIAGQVAKILGATVYGIAGSDEKCRWLVDELKFDGALNYKSADFAEKFKSLAQGKIDVFYDNVGGEVLDLALLCANKNARFVMCGGVSQYNAQEVQGPKNYMMIWRSRIRMEGFIVFDHMDRVPEVKRKLGEWLAEGRLQRRETIVRGGIAQAETALVQLYHGVNTGKLLVEVKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P384</accession>
    <name>A0A0G4P384_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S004g000654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P384"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL20713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="106" mass="12261" checksum="B4581A7C8F99534D" modified="2015-09-16" version="1">MLCNNQLISSISDGHLEMLTRLRTRAESRESAREEIFEEACILMQDAQGILRLAHTYDQSPTASTLHAMEQRMQLLLHEMADLRYEGVHDSRILSAIWDQTGEYMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3Q1</accession>
    <name>A0A0G4P3Q1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S005g000139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL20975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P3Q1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL20975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="97" mass="10966" checksum="4C2B03FC9C649C16" modified="2015-09-16" version="1">MLVSDSQRSVFLKVNNDSEWSEHLVPARLGNYQEVLGFLVHMFRTAATMSPVQSEKISVQTHSKESSGDPYMGFDVDAEEESSDEEEVRCFCSVLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3Y5</accession>
    <name>A0A0G4P3Y5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">beta-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S005g000137</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL20973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P3Y5"/>
    <dbReference type="STRING" id="1429867.A0A0G4P3Y5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF10">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL20973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="312" mass="34382" checksum="4CFC7DC7B2DFD1F3" modified="2015-09-16" version="1">MATTRVRTKRILQAPLPPLNVGSSKTTSSAFHGLEYVGTLSQWPNFKSQVEAFYNAQAFARSATAAVSPGLHNVDPEIVCVGDEHGLQGRFQQAIGQVLGGALEAQGVNLHFADFKCSGLQYQNVPDVVGLSTIVQGTAVQGTTVQGRKVLRLVGELKVPWVPQHSLRDAYDKPQRLRHILGQPLLYMGELGSAFGFLSTYNQTIFLRQIQLPSGNWHVEYSPVIYSSDAYVPSHTQGNSTVSSVSMRQLYLLSFQIAVQYSDPWAFMTSYNMINGVNAAEDPSLLTRVLRDEWRSDAVTVCDWYGPTLSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P4B0</accession>
    <name>A0A0G4P4B0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S005g000340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P4B0"/>
    <dbReference type="STRING" id="1429867.A0A0G4P4B0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="102"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL21176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="351" mass="39105" checksum="E0F2B756E85702D5" modified="2015-09-16" version="1">MSSENQEYSQEYSVDQEIIHFFQKTSTDRSLCDDRAHKLVGGTVTPVAVQGVCSYSVYAGPNHEHVVQFRLRSLGLKTEIANIASNVYGSLVPSVSYHGQIGGDDVSGKEPLSVYVMSRVKGISYLDFILAHNLPENSPEYFTWRENLISDIARLFALTWKSPQNLDRAFRGNLYQRYDEDLRRLLVALPDRFHPIIQQSIDALPAIFSLPMVLLHKDFGMCNVMVDADNNHLVGIIDWAEADIGPFGTNLHSLQQFMSKYRLGVGWIRYGNYDTLNSSFWNILSAGAGGGEATIRTIKSAMIVGLLLSHGFTSRLANMPKPEPIRDDESGAYEMLGLDGLLIVPATKLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P4D7</accession>
    <name>A0A0G4P4D7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">High mobility group, superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S005g000317</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P4D7"/>
    <dbReference type="STRING" id="1429867.A0A0G4P4D7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033193">
        <property type="term" value="C:Lsd1/2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </evidence>
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    </evidence>
    <sequence length="1096" mass="121256" checksum="3138ADC901FC6E82" modified="2015-09-16" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="109" mass="12060" checksum="BD2C1E3797D3A585" modified="2015-09-16" version="1">MAALAIPNLVRPIPELLPHIRADLQIFGVPLGGPKARTCGSEFDLLWSGELFRNLFQPLCIPGDDVTTSLQGNSEIGGRAKLQNSTNSSLLFMGMGRRSYRKRQRNMHP</sequence>
</entry>
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    <accession>A0A0G4P5N1</accession>
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        </lineage>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
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                <person name="Bensimon A."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
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        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
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    </dbReference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL21620.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="360" mass="39885" checksum="06E464C97C3C4A26" modified="2015-09-16" version="1">MSRKHHDISSDRLLITGVTGYIGFKTLTIALTRGYRVRAVVRTERNIKELKEKSTIIVQSLDQEQLEFVVIPQFLETDAIFNSLEEITVIIHLASPLAIETDDYDVGIVKPAISMVTTVLEAATRVASIRRVILTSSCVTLIPFEWNLNPDSQRLYTAEDVNTSVTGPFSTAMEAYWASKALARVATKEFVNHARPKFDFVNLLPSVVIGPDDRLDADPTATADSLLQGTRAAVLAPALTSSLNSSFPYVGTPVHVADVARAHVDAVDDGLVPGNSEYILSSDTPNGVVWDRDVQDVCRKFFSREVANKRLPLGGSLTAIKWRLSAQQTEETFGWRFTGFEETARQLLSQYLQLKDRSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6Y7</accession>
    <name>A0A0G4P6Y7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S007g000052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P6Y7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL22071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="127" mass="14331" checksum="D028D03A17D5CFF5" modified="2015-09-16" version="1">MLYAPTVFKGNGQAILEPYQSGPGLRWITVKLSNGDRHLCDADLMHMVIERLQDEEVVVNSESNQQTKKPFEMSFPVVDSSPRYQQCIDIVVEIAKSYRDGIVAGHIFVDHDYVFDLATSNTASLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7D9</accession>
    <name>A0A0G4P7D9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine/threonine-protein kinase DCLK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S007g000196</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P7D9"/>
    <dbReference type="STRING" id="1429867.A0A0G4P7D9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="112"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL22215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="318" mass="35593" checksum="672C08B7524AD7F2" modified="2015-09-16" version="1">MSDNRGTLFPRSTDIASGTIPQNNNDDNREIESHTDINDNRITVFPRSTEIGDSESDTRNISEPQNREVQRLPKRHLPAQWLQLPVKGTAKADEPGPKRQAPLFCKDHTPWIKYQRFKQGAKPGKTCLAYATDSPGTVVAIKEYKTSGIDKTCHLKMISHPNIVNLLDAFEQSRILYLAYELMDISLEQLQSGIQLKESDLAFICKELLHGLWYIHRDLGVCHTALTYDNVFISSQGSVKIAACLLERHQGSEQFDIKSIGIMICKVLEPGLSAHDLQACYASISHGSDSLRAFISTTATATIQALLQLLKDAWLYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7T4</accession>
    <name>A0A0G4P7T4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Eukaryotic translation initiation factor 2 subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S007g000333</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF2B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P7T4"/>
    <dbReference type="STRING" id="1429867.A0A0G4P7T4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04452">
        <property type="entry name" value="S1_IF2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1130:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000015">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.190:FF:000002">
        <property type="entry name" value="Translation initiation factor 2, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.190">
        <property type="entry name" value="Translation initiation factor 2, subunit 1, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044126">
        <property type="entry name" value="S1_IF2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024054">
        <property type="entry name" value="TIF2_asu_middle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
        <property type="entry name" value="eIF-2-alpha, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116742">
        <property type="entry name" value="eIF2alpha middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="17"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="289"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL22352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="301" mass="34185" checksum="82EB0564764CEA6D" modified="2015-09-16" version="1">MSLTNCRFYEDKYPEVDSFVMVNVKQIAEMGAYVKLLEYDNIDGMILLSELSRRRIRSIQKLIRIGRNEVVIVLRYIDLSKRRVSPEDVIKCEERYNKSKAVHSIMRHVAEATQTPLETLYENIGWPLNQKYGHAHDAFKISITNPNVWDEITFPSDAVKSELQQYISSKLTPHPTKVRADIEVTCFGYDGIDAVKDALRTAEADNTPENQIKVRLVAPPLYVLASQCLDKTLGVKLLEEAIVKIEERIKANGGSCTVKMAPKAVTEHDDAILQELMEKRERENTQVSGDEDSESDEGVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7T6</accession>
    <name>A0A0G4P7T6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Serine/threonine-protein kinase SSN3</fullName>
            <ecNumber evidence="6">2.7.11.22</ecNumber>
            <ecNumber evidence="5">2.7.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Cyclin-dependent kinase 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Serine/threonine-protein kinase ssn3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">PCAMFM013_S007g000379</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the SRB8-11 complex, a regulatory module of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="6"/>
    <dbReference type="EC" id="2.7.11.23" evidence="5"/>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P7T6"/>
    <dbReference type="STRING" id="1429867.A0A0G4P7T6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07842">
        <property type="entry name" value="STKc_CDK8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000408">
        <property type="entry name" value="Serine/threonine-protein kinase SSN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000426">
        <property type="entry name" value="Serine/threonine-protein kinase ssn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF495">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0010">Activator</keyword>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 27" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="15" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="26">
        <location>
            <begin position="51"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="399"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00039418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00040708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00041823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="CRL22398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="437" mass="48974" checksum="1E83DECA6F51FE0D" modified="2015-09-16" version="1">MSLTNPPSSSGSLSRTRVGNLKRSLQATVDDAIESRRPGGYTSKVRVRDRYNIVGFISSGTYGRVYKAVGKNGKKGEFAIKKFKPDKEGETIQYTGLSQSAIREMALCTELSHANVVQLEEIILEDKCIFMVFEYTEHDLLQIIHHHTQPQRHAIPAAMVRSIMFQLLNGLLYLHTNWVLHRDLKPANILVTSSGAIRIGDLGLARLFYKPLNSLFSGDKVVVTIWYRAPELLMGSRHYTPAVDMWAIGCIFAELLSLRPIFKGEEAKMDSKKTVPFQRNQMMKIVEILGLPRKESWPGLASMPEYSQLQSLVLHRQPSHFHRGSNLEGWYQSCLKNGGYNSTSGAGTPGADGFDLLSRMLEYDPSKRITAEQALEHPYFTNGGPISGNCFEGIEGKYPHRRVTQDDNDIRTGSLPGTKRSGLPDDSLMRASKRLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7W1</accession>
    <name>A0A0G4P7W1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger, NHR/GATA-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S007g000363</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P7W1"/>
    <dbReference type="STRING" id="1429867.A0A0G4P7W1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000043">
        <property type="entry name" value="Sexual development transcription factor NsdD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172:SF24">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING PROTEIN 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172">
        <property type="entry name" value="OS01G0976800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="408"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="447"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="156"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL22382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="471" mass="50305" checksum="18DD6F171B78DF32" modified="2015-09-16" version="1">MGSLEAAPRHRDPLPAIGFLGKDGSGYTSRHPSSATASPTLMSPNVMYAGQPLPYSYASNAPPGYISSPEARRTLEDEKEKQNPRQSLPSIHEALGNDNPLPYPASTSAPPQQSTHSAPPSHLIGRPSAEGPAGPPNPFSNGPPTGPLMREPGFSHQGQLQDASRSSLASISTQDSRNPSLHSISTGKSPTQSAKTGITSVGSQNSSGYEYSAPTSAGSVASPNGYGHFPPNYSFPPQSGGHSYPPAPYDNRAYMGAPRVEEVKGGFVGRPGPPPHSDSGKRHLDVYDVETSLNEIAELSTRTLDFSRHYAARAHQTQRSGPLLGSLPSLNEVEDMLHMQRRNQDALIRIRTAVVNQEQALAEQMAQRKAFKTEDDHMAMYQEEFKGTGGFAGADPKKRRGKAAPPGRCHSCNRAETPEWRRGPDGARTLCNACGLHYAKLTRKMGAHKAASLGSNLKPKSVLDSASPTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7W5</accession>
    <name>A0A0G4P7W5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S007g000402</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P7W5"/>
    <dbReference type="STRING" id="1429867.A0A0G4P7W5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36151">
        <property type="entry name" value="BLR2777 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36151:SF3">
        <property type="entry name" value="ER-BOUND OXYGENASE MPAB_MPAB'_RUBBER OXYGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic" evidence="2">
        <location>
            <begin position="48"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL22421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="309" mass="34454" checksum="11B5CC12CF9E2679" modified="2015-09-16" version="1">MSSPPSPVSPVDEKPHDLPNGSDATASNITNVPGRLHALEQLEVLPKMLQEGILFAGSGATLLLQAAMPAIREAGANHGGHKELATELIDALQANISYVSCLVFGTRSERKVLIDLLQDGNPPLLGSGRSNRFAEHPPLQLWMAATLYATATDFYQRVYGRVDYASAQRAYSEYALLVNCLGLPVGTWPESRQAFWSYWDDQVHQLTVSSDAAQFAKDLRESNDMPRWVQSLKPFLRVTTIEMLPPSLRDAYGLRSTMTTRALYRTWMGFSVALYPAMPDEWRAYPLKFYQDRLKEKMDGKETIDGKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P8D7</accession>
    <name>A0A0G4P8D7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S007g000551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P8D7"/>
    <dbReference type="STRING" id="1429867.A0A0G4P8D7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL22570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="98" mass="11244" checksum="459D1A39C43C57B1" modified="2015-09-16" version="1">MTHEFECPYAVGNVIKIHLKTPDGLEATADANIIKVFEPFTLSSVMLIRMACSSLRLEGDMILKLFDRRFATQLREDEKIRPWTPDAETGYPQRRSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P8I8</accession>
    <name>A0A0G4P8I8_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S008g000049</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P8I8"/>
    <dbReference type="STRING" id="1429867.A0A0G4P8I8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000924">
        <property type="entry name" value="Cell division protein kinase (Ctk1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF576">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CSK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="103"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL22620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="394" mass="43970" checksum="5CEDBDB27383B01E" modified="2015-09-16" version="1">MSWKDNFGFTDRLRAIQSLTTAYQQASSSPASAFAEAMAQAKQLETEAYDKATSKDEYESICQKAIDEAELAGSKKLATSSPQHVEDDYEESETSTGEVIGQYRSCSHHYGGLHSSIYRSKWEDGTVRAVKVTIPHMMTAPHDAHREARLLREASHPHIIPLIETFNLDGGRFVLVFPFMRYDFEQLLRRDMVSAAQTRSILRDLFCALAHLHSMGILHRDIKPSNILMDSPNGPAYLADFGISWKEGDVGSEPPTQKITDVGTTSYRPPEILFGFKEYGTSLDMWAAGCVVAEAIAVGHHQLFDSGPVGSDLSLIFSIFKLLGTPDEQRWPEVQVLPDWGKVEFHSFPTQPWEDILPGASSNGRDLVSHLLRYESSERLSATEALAHPYFART</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P9H7</accession>
    <name>A0A0G4P9H7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S008g000391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TEL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PD17"/>
    <dbReference type="STRING" id="1429867.A0A0G4PD17"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.720">
        <property type="entry name" value="Telomere length regulation protein 2, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038528">
        <property type="entry name" value="TEL2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051970">
        <property type="entry name" value="TEL2_Regulation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019337">
        <property type="entry name" value="Telomere_length_regulation_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830:SF10">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10193">
        <property type="entry name" value="Telomere_reg-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomere length regulation protein conserved" evidence="3">
        <location>
            <begin position="607"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="535"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="562"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL24144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1007" mass="110518" checksum="71A1D974E5383A96" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PEE4</accession>
    <name>A0A0G4PEE4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase PFA4</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Protein S-acyltransferase</fullName>
            <shortName evidence="11">PAT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Protein fatty acyltransferase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PFA4</name>
        <name evidence="15" type="ORF">PCAMFM013_S012g000246</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11 12">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11 12">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DHHC palmitoyltransferase family. PFA4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PEE4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PEE4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03199">
        <property type="entry name" value="DHHC_PAT_PFA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033682">
        <property type="entry name" value="PFA4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0564">Palmitate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="14">
        <location>
            <begin position="89"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="294"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="342"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="372"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="389"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="404"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="active site" description="S-palmitoyl cysteine intermediate" evidence="11">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CRL24636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="431" mass="50168" checksum="258363C697D30B00" modified="2015-09-16" version="1">MLGEDFSITKFAIPGVSVLIAFLAYTSQYFFLHFEPVPLTRDETWKINIFALCIWICYYRTCFVDPGRLPKSQERPKPKEQEGDALASRQRWCRRCEAYKPPRAHHCKTCKRCIPKMDHHCPWTSNCVSHFTLPHFMRFLFYATVGMSYLETLLWQRASFVWKNSHLPSYLGPTLGQLIHLFILLVVNSLTTFGLFVLLLRSLWSIGSNTTTIETWEIERHATLVRRARVLGGYLEGPGGIRVRIKKQEYPYDIGIWANIKQSMGGSANFISWFWPLAATPDRRTGWEFKTNEFEDPGVSWPPPDPDRIPIPASARPPSNMSMPTYATIQDEIDAFNRRKQEDMKRFQQSPGLQRRKPFYDRYKKRDNAQSDSDESETDSEGYSDEGEEAWRNAEGERLRDFGVDEETEFYDEEDIPLGVLIERRKQQSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PEJ3</accession>
    <name>A0A0G4PEJ3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S012g000363</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PEJ3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PEJ3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL24753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="388" mass="44794" checksum="9391D6D49D20946C" modified="2015-09-16" version="1">MIPISIVPASGALPFLGLLLSILTWVIVKWPIRRKSSTSQIQQPEKEPFIKPLPSPHPNDPTSNDPKLYRPFRHGPNFITMGIRKLHWDNWIEMDSYFLRYHDMKAAELKKDFKEHIKYVDNAVTKDACFELNEELVRHLTHRYPKTFRLEGGKVHNSLTGEAFPFPAATPDEALATSALLVQDDLVLMMKNDDGEYHLDAAAVCLPGFWRLREKFRMSLDTLHFEAGVPHYAAKLQKAMNKFMLKLTPDKPVERNNFFIQLDDGLHWSHRMGDQQGTEVASWATANGKGLTIDEIHFRSERQTLRRLPRSGAILFTIRTYFEPVTKLAQEPYIPGRLAEAIGNWDETVSYYKGKSSWDKILMPYLEEQDRLQKERGVVGENEVEFPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PER4</accession>
    <name>A0A0G4PER4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S013g000007</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10 11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Cytoplasmic vesicle</location>
            <location evidence="10 11">COPI-coated vesicle membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Golgi apparatus membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL24765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PER4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PER4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051645">
        <property type="term" value="P:Golgi localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09254">
        <property type="entry name" value="AP_delta-COPI_MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14830">
        <property type="entry name" value="Delta_COP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000003">
        <property type="entry name" value="Coatomer subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027059">
        <property type="entry name" value="Coatomer_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121:SF0">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="13">
        <location>
            <begin position="276"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="154"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CRL24765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="515" mass="57452" checksum="E35E9FA9CE92080C" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PFT1</accession>
    <name>A0A0G4PFT1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S014g000053</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PFT1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PFT1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL25157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="385" mass="44501" checksum="F5A6DDC95C61C683" modified="2015-09-16" version="1">MEILHFAPSEMTGESTVFTLSTSSDLKILVTEWFEGYVSESSDKSSDSEVSEDHPARFNSPRAPITEKAIFYVKRSVLAENNVWLAKEQDDTINLRTDEPYGIKGLCVWLAAFHGQSTPFSTMSIDDIWGAIKVGNINDFDRRKLQPWFEGWVARIRDEQPVKWNDVLFNRQLLFPCHFFDDAEGFKHLTRCLVYNTHWSSPIKESKPIEFNRRGLNPEFVTHQLNAVRDRLRTTLQGQISAEVDRCLKQSPCDCNETAICAYLKEVNRIGIAPWGDTFSQSSIKEITDKLELFDQAHIRKPNVKPCDCECSPPCGCSIAWDEAVKKFRKDTLEYFDGLCLDCMKHSPRKNSKYWNRPSHQDGYDKDCRIEHGKVSWYFSFMGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PG78</accession>
    <name>A0A0G4PG78_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S014g000171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PG78"/>
    <dbReference type="STRING" id="1429867.A0A0G4PG78"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL25275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="242" mass="28487" checksum="5B06B3CB5955E681" modified="2015-09-16" version="1">MSSVTLKLRQKRSMARLLNQGRSILDYNFDPNAFIIPQWILVPPEVRNAMLTLQYKAMIAVYGMKSLMIARDHRYFELCPKNMGPIVYQLHQSSMRRLLEWKEDWNFADPTLAASAKIPRSTLQFCVDSIAYGKFTCDYTNKIDGFMSGPFQSWRQFRMEIGHLASRLMSHRPHDYNEWRAWWEGKFADDMWKWEVCLEGMILPTWEEIIDDVYLMINDRVEDAQELAKSFYISTPGRASTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGD7</accession>
    <name>A0A0G4PGD7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S014g000277</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PGD7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL25381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="343" mass="37074" checksum="5CA4C4CC1D272834" modified="2015-09-16" version="1">MKLSLFRKTKPGVPEHSLYPTEGAIGMKVLSDPSNADLDIIFVHGLTGNREKTWTHENGTVWPRDLLSKDLSTARIMTFGYDVDIFSFTSITFSDRLYDHSQSLAFAIVSQRIDCSSRPIIFIAHSLGGLVCQQALILSNSIDGLWAISSSAIGIIFMGTPQYGSSLASYREKLAKGLNIVHTANRDMVGALHLGSNNVQLAGNEFQSMLRRGDLSLKVFCFYEAKNMNDVVGKIVEEHSAILQGYDSCRISADHYNMTKFSGHADSGYGLVRSIVTGWLHESRGGDDAANKAAMAASVSGNPGWLGSWTPGNFYFNGAANSQSCAQGHYTQAVTGLALGASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGH5</accession>
    <name>A0A0G4PGH5_PENC3</name>
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        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">PCAMFM013_S015g000012</name>
    </gene>
    <organism evidence="1 2">
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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                <person name="Brygoo Y."/>
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            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL25426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="67" mass="7790" checksum="9E87E0E656C080B9" modified="2015-09-16" version="1">MLISLGNDCDLDLDEIWRDSSSLSTPALTLTVNYDDRLYFLNVAERAKYEVQQPLLVECFFYPDHES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PH19</accession>
    <name>A0A0G4PH19_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S015g000204</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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            <dbReference type="PubMed" id="24407037"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CRL25618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="48" mass="5447" checksum="82CDEA5387A6F3FC" modified="2015-09-16" version="1">MPAFVALLTCILKTTTPPSGQFSKSLRLFAEINRFHEPITSSLLILWR</sequence>
</entry>
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    <accession>A0A0G4PHD4</accession>
    <name>A0A0G4PHD4_PENC3</name>
    <protein>
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            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">PCAMFM013_S016g000020</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
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            <taxon>Eurotiomycetes</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793149">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PHD4"/>
    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL25739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="68" mass="7389" checksum="C5CF29B27FA87298" modified="2015-09-16" version="1">MFEEERDDSHTGSRKVTGLHLSWTSKGQPGVALSIHEGQFLIEPGIGSLLEKPVSIYSNVHDAIGTPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PI76</accession>
    <name>A0A0G4PI76_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zinc finger, C2H2-type/integrase, DNA-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S017g000017</name>
    </gene>
    <organism evidence="12 13">
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793150">
        <property type="protein sequence ID" value="CRL26034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PI76"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001666">
        <property type="entry name" value="MDS1 and EVI1 complex locus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF70">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="264"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="343"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="565"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="154"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="343"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="382"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="405"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="441"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="475"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="508"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL26034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="584" mass="62742" checksum="A445BBBB0BEE5692" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJ97</accession>
    <name>A0A0G4PJ97_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CoA-transferase family III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S018g000173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJ97"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJ97"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050509">
        <property type="entry name" value="CoA-transferase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228:SF5">
        <property type="entry name" value="ALPHA-METHYLACYL-COA RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228">
        <property type="entry name" value="SUCCINYL-COA--D-CITRAMALATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL26480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="377" mass="40951" checksum="94D39F0155E27CAD" modified="2015-09-16" version="1">MSPLKGIKVIELAGLAPGPFAGLLLADYGASVLRIDRPNSISGDQLTRNKTSITLDLRSEASLNILLRLLTTADILIDPFRPGVLERLGLSPTEVLLKHNPRLIVARMTGFRRDGKYKDMAGHDINYLAVSGVLSMLGRAAEKPHAPGNILGDFAGGGAVCFQGILLALISRSHTGRGQVVEANMVDGSAYLATFPRLGRNTPSWAEPRGENLLDGGCPYYDTYETKDVGQYFAVGALEPQFYAALVQGLGFEIGELPKREDRKHWPALRGIFTRRFKEKTRAEWEAVFDGTDACATPVLEQRELEESGYEQRPVVHLVSTPAAPILADKGGWTGGGMLPGDGGVDTLREWVGWEHGKDFEVREDGAFVVVNGKAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJU1</accession>
    <name>A0A0G4PJU1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Clathrin adaptor, mu subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S018g000111</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJU1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJU1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030665">
        <property type="term" value="C:clathrin-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09250">
        <property type="entry name" value="AP-1_Mu1_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14835">
        <property type="entry name" value="AP1_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000006">
        <property type="entry name" value="AP-1 complex subunit mu-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="8">
        <location>
            <begin position="167"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL26418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="447" mass="50686" checksum="5FFBB266DF0E1131" modified="2015-09-16" version="1">MASALFFLDLKGKTLLARNYRGDIPMSAVEKFPILLSDAEEESSAVPPCFSHEGINYLYIRHSNLYILALTKRNTNATEILLFLHKLVEVFTEYFKVLEEESIRDNFVVIYELLDEMMDFGYPQTTESKILQEYITQESHKLDVQARPPIAVTNAVSWRSEGIRYRKNEVFLDVVESLNLLVSANGNVLRSEILGAVKMKCYLSGMPELRLGLNDKAMFETTGRATRGKSVEMEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTQVKPLIWVECVVESHSGSRIEYMLKAKAQFKRRSTANNVEILVPVPEDADSPRFRTNIGTVHYAPEKSAIIWKIKQFGGGKEFLMRAELGLPSVKGDDERRGGMTGGFGGSMGGAGGVGKAKRPINVKFEIPYFTTSGIQVRYLKITEPKLQYPSLPWVRYITQSGDIAMRMPEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PK85</accession>
    <name>A0A0G4PK85_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S019g000007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PK85"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL26591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="124" mass="13993" checksum="66A31E69502049F3" modified="2015-09-16" version="1">MSNGDQYSDMSAEEQLTPPIRRENERRNVFEDIVAEENVFQFVGSTNGHTTTARSVTSKAYATQCLGDASETTIQQISKDRSGITAKKQHPHHQQQTNSFEGRGRTLGDKFQVCYLEIIYLHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKD0</accession>
    <name>A0A0G4PKD0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S020g000006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793153">
        <property type="protein sequence ID" value="CRL26847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKD0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PKD0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL26847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="333" mass="36296" checksum="A8A55BA21E28F322" modified="2015-09-16" version="1">MPLLSSLEGISSTVFSNTFIELPYPEGDLSGQTIIVTGSNQGLGLEASRHLLRLGVERLIMAVRDLKKGESARQELLQSTSREESSIEVWLLDMDSYFSVKSFASRAAALPRLDALLANAGLATNTFSISEEDEKTITVNVVSTFLLILLLVPKLQESASKFNITPRVTIPNSALHYIASLEHLDPQKEGGIFKSLNNKEASNMAGRYPLSKLLVVFGVRALADQLTRSKAPLVIINTPNPSFCKSQLARETDNVGLRVSEKLLARSTEEGSRALVHGIMADEKSNGQYLTNCHVHSPSCIVTDKKGVLIQDAFFKELVAKLERIAPGVTSCL</sequence>
</entry>
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    <accession>A0A0G4PM64</accession>
    <name>A0A0G4PM64_PENC3</name>
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        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7703" evidence="2">
        <location>
            <begin position="26"/>
            <end position="258"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL27271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="367" mass="42092" checksum="BED7E54641AF1A91" modified="2015-09-16" version="1">MGDFTAAGDGISGHYQGTSLGMQITIATLAGVTWYNAFELMILLFVTFAEYRGLYFWSLFISSSAGLLPYSLGFLLKFFQITDDLPWLPVTLLTIGWWSMVTGQSVVLYSRLHLVLSNQRVLRRVLMMIVINAIILHLPTTVLTYGTNMADDASLGLWTKGYNIMEKIQMTGFCLQEFIISGLYIWETVRMLRLDPDRIKRKIQYQLLIINFIIIILDVGLLVAEYLDFYIMETMLKGVVYSIKLKLEFAVLGKLIHLVHNHVWKPESFSAPRDLPDFVDATRVTSDMTHASPSVVHRRPSRMDVDDISIAMFEHLPSDRIRTNSDLSHSWSNEARAYHVDHLPVDFTNPFRHYPRHQSREIPEKPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00106">
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL27625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="578" mass="64133" checksum="B4A1B2DE41848523" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMG7</accession>
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        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
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                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <location>
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            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
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            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL27637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="390" mass="43430" checksum="0451DE19E610CDED" modified="2015-09-16" version="1">MANYSWQPQAPSTGSQWLQDNASYSQSTMQDLTHAFPRPRHTRVMKPRSAGNSPSSATRRRSTVNQNVMHGLPTQYQSTLEEALLTSAARNSRPMSWHPSSARTRGLSNPYISDFPSNGYAGMEAMPDQYLSSDIYCDDNSISYPMTADPSFSPNYFPVYSTMQEDLPLPQHTPALMTQLDPMGWEAAAMSTDMSMMSHPASDNWNLDMLSMGTNIPPPETTCPSYVSVPSPGELSGPSTPDFLPIQQFENPFQITAEPKKTGKGEEELVGMGLYSQPNGTLARAPQSKSGEGLKLEETFTPSDEDKDDETDEVEIIGQREVPQQPTYHESAPTIRQSNFTSKQQPRQALNLLQRSFFFDHDDTEQQQMTAAQPFAGFNQPCMNYGYGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PML8</accession>
    <name>A0A0G4PML8_PENC3</name>
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        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S023g000150</name>
    </gene>
    <organism evidence="3 4">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793156">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PML8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025979">
        <property type="entry name" value="ChrR-like_cupin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12973">
        <property type="entry name" value="Cupin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ChrR-like cupin" evidence="2">
        <location>
            <begin position="77"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL27692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="177" mass="19697" checksum="D7C0D48223FCB3F5" modified="2015-09-16" version="1">MWTGSLKYNLKGTVPPSPALQKQPPHLPNIPHLATSLSPPSQKKETKKNPTKMPIHQKEFSTPPPHPPVGTPRDSPSALPWYSIAPGVWEFLLNGDEEHKAVLQWWEPNTVSAQTEPITHTYIEEVCTLRGGLEDLSFGESWGIGAYAYREPGMEHGPYQATKEGCLQFVKVVPVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMV9</accession>
    <name>A0A0G4PMV9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclin-like F-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S022g000161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793155">
        <property type="protein sequence ID" value="CRL27481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PMV9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PMV9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="60"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL27481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="342" mass="38853" checksum="41A3CDC5CA9C34F2" modified="2015-09-16" version="1">MQLGKTAASTCMSEMEIIRATSYHRRDFDLAVTRTNPDDHNRVRSSLLRTARATSSTSTLGNLQSLPLEIIYKICYLLDIRSLFNFRHVSRRAQQIVRGTRGYELVITHALEALCVTVRTNIAPWFTLTDLFTVLCTRDCHLCGSFGGFLFLPLFTRCCFSCIREDSLPSILLYSIVKKRVKMSSVPTVKSLPGAYSMEEIVRKRRVQIAATEFVSRLSLYKEDEITQATPRGRALLCYMVTTSLPYLDTESGGIQNGICCGGCQIALERDLASSRVKSNACVLRDKVYSYDEFTQHFRECPDAQNLWKLRNQGVDITNLSEFVRRGGHFKERDIIMSFNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PN64</accession>
    <name>A0A0G4PN64_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein mL38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S023g000074</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the phosphatidylethanolamine-binding protein family. Mitochondrion-specific ribosomal protein mL38 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793156">
        <property type="protein sequence ID" value="CRL27616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PN64"/>
    <dbReference type="STRING" id="1429867.A0A0G4PN64"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1180:FF:000001">
        <property type="entry name" value="Mitochondrial large ribosomal subunit YmL35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.280.10:FF:000004">
        <property type="entry name" value="Mitochondrial large ribosomal subunit YmL35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF82">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL27616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="418" mass="47984" checksum="DA92A59989FDDC43" modified="2015-09-16" version="1">MAHCERASKPLIQCLRNTYYRGVAGVQLQTRAFQSTANVREPEAETPSQPFHKAPDPSLVTSPRLERRLLRQGTAPIGSRRRRAALQDSENLPFEQLPYQCFQEARKILLADREEKLKEIETMRQRLARQEALSVEEAGGEKAKKSRVTAMQLHLERLKVLADINDPLVKRKFEDNEGDMSKPIYRFLADRKWREYRRKIQVQRITQMNVVPDVLPHCDPVVETKLYFGKRQVQAGEFVEAKLSTSAPKLDVQMFEGGEKLVTIAVVDPDVPNVENDNFDYKTHFLAVNVPISATSTKVDLAQLLEDSQVVLPWLPPVAQKGSPYHRLSLFIMEQKDSQPLDFAAVKAKESSRDNTLLRTLQSRYHLKAIGAHLFRTQWDDTTLEVMKEIGFDGASVELRRKRVEPLPYKRRNPSSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PN83</accession>
    <name>A0A0G4PN83_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Inositol-pentakisphosphate 2-kinase</fullName>
            <ecNumber evidence="4 10">2.7.1.158</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S024g000105</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Has kinase activity and phosphorylates inositol-1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) to produce 1,2,3,4,5,6-hexakisphosphate (InsP6), also known as phytate.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20313"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.158"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="10">The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IPK1 type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.158" evidence="4 10"/>
    <dbReference type="EMBL" id="HG793157">
        <property type="protein sequence ID" value="CRL27850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PN83"/>
    <dbReference type="STRING" id="1429867.A0A0G4PN83"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035299">
        <property type="term" value="F:inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.110">
        <property type="entry name" value="Inositol-pentakisphosphate 2-kinase, N-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009286">
        <property type="entry name" value="Ins_P5_2-kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043001">
        <property type="entry name" value="IP5_2-K_N_lobe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456:SF2">
        <property type="entry name" value="INOSITOL-PENTAKISPHOSPHATE 2-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06090">
        <property type="entry name" value="Ins_P5_2-kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL27850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="348" mass="39186" checksum="863F6AC6CA05123D" modified="2015-09-16" version="1">MTKPNLLELPSGVQLVYLAEGGANVIYRFVRIPVTKKDPKRPLSPPAHDPDHCHLPTQLKGKLLRLRKETAADISYTEIVRNFDTIIRPLFNPEELVDQTLIRLPEGLLTSCNEQLRTAELNGARPKKRHGSYLCLHEPFGLLITDMTTAGDPGATLAELKPKWLNQSPSAPTTAHRCRTCALREMKNRESQLQGLKEQRSFCPLDLMSEQYENVLRATGLIKGCKDRSRLARILYRNPILQRLQSLQKTQRDVGLQGPSAQSREMSLAMTLRDCTMFIKIPHDEKSPVEIRLGDLDLKTGAGGKAGYWRDLETRLIDQGWYRGSNISQSSGDCALHSPRRPSQSYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNH9</accession>
    <name>A0A0G4PNH9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AMP-dependent synthetase/ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S023g000189</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793156">
        <property type="protein sequence ID" value="CRL27731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PNH9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PNH9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="453"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL27731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="556" mass="61645" checksum="3C1E20FA8755DCF5" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNI0</accession>
    <name>A0A0G4PNI0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S024g000174</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793157">
        <property type="protein sequence ID" value="CRL27919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PNI0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PNI0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15853">
        <property type="entry name" value="SNARE_Bet1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000057">
        <property type="entry name" value="SNARE complex subunit (Bet1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039899">
        <property type="entry name" value="BET1_SNARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL27919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="168" mass="18487" checksum="D7E6BAE301070DD1" modified="2015-09-16" version="1">MASRFPRQRDPRASSSLFDQYGGDSRQASRSPAQQPGGYGYGGYSSPAPNGYASSGAAGAGYQSASPDKKGHYSDAVLSSLESQNDAEVEGISAKVKMLKDITIAIGDEIRDTTHITDLNDSFDNTRVRLRGNMNRMLRMAESTGIGWRVWLGFFFAVFLLFFYVWIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNI8</accession>
    <name>A0A0G4PNI8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Formylmethanofuran dehydrogenase, subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S025g000008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793158">
        <property type="protein sequence ID" value="CRL27950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PNI8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PNI8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642:SF19">
        <property type="entry name" value="AMIDOHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G01480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase 3" evidence="1">
        <location>
            <begin position="51"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL27950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="540" mass="58798" checksum="9BC8DF6B5DAEEF65" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNS1</accession>
    <name>A0A0G4PNS1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S025g000097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793158">
        <property type="protein sequence ID" value="CRL28039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PNS1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL28039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="243" mass="28008" checksum="EA76D69E1BC58594" modified="2015-09-16" version="1">MEPRPTIKFKLNGVSTSEADIDNLELQACYRALDNLRSLLFQAPMLDLLKDQIEEGNDYFESLIRASRGEFRECRTYMKATGVSATEMRTICHRWQLSKPIDEMARMFIFPTHPENYVVMHSPGAPDENGPDCGVEVIGGHMAKIQFVDLMDSVIPKWMTDQREEEYEMVEYLVAKLESGSKFFYVMNEFMDTESGCKIKLRAFFPSASPWSLVNEHAEHLAVEFRNLLQMVYGAIEELEDSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNV3</accession>
    <name>A0A0G4PNV3_PENC3</name>
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        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S024g000078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793157">
        <property type="protein sequence ID" value="CRL27823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PNV3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL27823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="158" mass="17557" checksum="2843658530AA75BD" modified="2015-09-16" version="1">MPPAMEDAVVLSNESLGSRALEQSASQGPTLPRADRARRPPEYYSDIEYDRAGRPKAPAPPTPEPNMEVAGESESEAGWVTEEGEEEDEMDLSVSLRESTEKQKNADSEGFDKRTGIQERMKSRSCQYIGHLLSNNIEYINNLERSDLQNGVRISGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNW7</accession>
    <name>A0A0G4PNW7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S025g000123</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CRL28065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PNW7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000001">
        <property type="entry name" value="Fungal specific transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374:SF1">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE PAD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="50"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="172"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="685"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="733"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="747"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL28065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="812" mass="88440" checksum="358FAC23CEC85688" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNY9</accession>
    <name>A0A0G4PNY9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cation/H+ exchanger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S024g000153</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal Na(+)/H(+) exchanger family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793157">
        <property type="protein sequence ID" value="CRL27898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PNY9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000015">
        <property type="entry name" value="Na(+)/H(+) antiporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF1">
        <property type="entry name" value="SODIUM ION_PROTON EXCHANGER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="257"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="13">
        <location>
            <begin position="25"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="467"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="467"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CRL27898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="538" mass="59682" checksum="8D4AEF59E8D34C73" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNZ8</accession>
    <name>A0A0G4PNZ8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S024g000168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793157">
        <property type="protein sequence ID" value="CRL27913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PNZ8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PNZ8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24306">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24306:SF7">
        <property type="entry name" value="AHBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL27913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="572" mass="64157" checksum="1374A2F05F501ABD" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQH5</accession>
    <name>A0A0G4PQH5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase-like hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S029g000071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793162">
        <property type="protein sequence ID" value="CRL28655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQH5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PQH5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07505">
        <property type="entry name" value="HAD_BPGM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044999">
        <property type="entry name" value="CbbY-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42896:SF2">
        <property type="entry name" value="CBBY-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42896">
        <property type="entry name" value="XYLULOSE-1,5-BISPHOSPHATE (XUBP) PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL28655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="253" mass="27977" checksum="71C37CD277B4E172" modified="2015-09-16" version="1">MTKITEIFFDCDNTLVLSEELAFEACADLANEILEANNFPDRYTGDQLIKDFVGQNFRGMMVSLQKKYDFEIDAEKLEEYVTKEEDKVIAKLNAKARPCIGASEELEKVYAAKKYGLAVVSSSALRRVLASIRKVGQDKYFDEDKVFSAASSLPKPTSKPDPAIYLYALEKVGKTASETVAIEDSKSGALSAVRAGIPVIAYVGSYNGEETQKEMAAALTDLGAKTVMYHWSEFEDRLKDIENDVSVDVQSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQM3</accession>
    <name>A0A0G4PQM3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter, conserved site</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S027g000115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793160">
        <property type="protein sequence ID" value="CRL28426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQM3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PQM3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000007">
        <property type="entry name" value="Cytoplasmic protein required for cell viability"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039796">
        <property type="entry name" value="MIP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIP18 family-like" evidence="3">
        <location>
            <begin position="66"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL28426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="194" mass="20998" checksum="DB237EF882DA3EE9" modified="2015-09-16" version="1">MAEMQNSNPTILNAADLPTRLRPTATRKSEYAGIFTSALPLAPVDFESVPSSDSEDDNLLEEPIDEQEIYDLISSISDPEHPISLGELAVVSLPDIAIKPTLPDVPDSPLQTVTVLITPTITHCSLATVIGLGVRVRLEQSLPSRFRMDVRIKEGTHSTGDEVNKQLADKERVAAALENGALMGVIAKMMETCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQM9</accession>
    <name>A0A0G4PQM9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S028g000006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793161">
        <property type="protein sequence ID" value="CRL28453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQM9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032157">
        <property type="entry name" value="PAC4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16093">
        <property type="entry name" value="PAC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL28453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="157" mass="16943" checksum="F01E8A300479E4D0" modified="2015-09-16" version="1">MATEAPPAVPLAELATPSVKPQEISFTLPKALHTTAHVHLNFLGHCAMVFLATSSPGDSGGSIKPMGSFVYAMPDRTSPKSTISTTLYTSPSSIEYTARIAKILARRFSIPVYVGCSIDPHGMGLEVAEEMEGLTKIVNVIMEKWEEHKQEKAANTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PR13</accession>
    <name>A0A0G4PR13_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Berberine/berberine-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S029g000029</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793162">
        <property type="protein sequence ID" value="CRL28613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PR13"/>
    <dbReference type="STRING" id="1429867.A0A0G4PR13"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195771" evidence="3">
        <location>
            <begin position="21"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="111"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL28613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="561" mass="61247" checksum="4DEE968233886062" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PSF9</accession>
    <name>A0A0G4PSF9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Riboflavin kinase</fullName>
            <ecNumber evidence="6">2.7.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Flavin mononucleotide kinase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PCAMFM013_S033g000028</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>riboflavin + ATP = FMN + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.26"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the flavokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="6"/>
    <dbReference type="EMBL" id="HG793166">
        <property type="protein sequence ID" value="CRL29108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PSF9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PSF9"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.30:FF:000008">
        <property type="entry name" value="Riboflavin kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749:SF6">
        <property type="entry name" value="RIBOFLAVIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="RIBOFLAVIN KINASE/FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0288">FMN</keyword>
    <keyword evidence="13 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Riboflavin kinase" evidence="19">
        <location>
            <begin position="15"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CRL29108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="206" mass="22667" checksum="DAFF491F95C013E3" modified="2015-09-16" version="1">MSKPRDPVAGPDSPEPPFPIRLSGPVIKGFGRGSKDLGIPTANIPADDLSEKHPELTTGVYYGVVALDPKTYHHETSEGSTSTAVVLPAVLSIGYNPFYKNTVRSVEIHIMPALTEPSPTAAGQEGHTKFNRLPDFYKTRLNLLILGYIRPEFDYVSLEALVEDIRVDCEVARESLLREAYKCYLVDSGKTSGKVSEDRAWLVSFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PSQ8</accession>
    <name>A0A0G4PSQ8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S033g000116</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
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                <person name="Branca A."/>
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                <person name="Debuchy R."/>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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</entry>
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    <accession>A0A0G4PUX2</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            </authorList>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="11"/>
    <dbReference type="EMBL" id="HG793174">
        <property type="protein sequence ID" value="CRL29934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PUX2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PUX2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17754">
        <property type="entry name" value="MCM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008046">
        <property type="entry name" value="Mcm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056575">
        <property type="entry name" value="WH_MCM3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF46">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23191">
        <property type="entry name" value="WHD_MCM3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01659">
        <property type="entry name" value="MCMPROTEIN3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="300"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="675"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="686"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="709"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="754"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CRL29934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="879" mass="96781" checksum="83AC700457F2EE92" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PV00</accession>
    <name>A0A0G4PV00_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Dopey, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S045g000037</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DOP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793178">
        <property type="protein sequence ID" value="CRL30171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4PV00"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040314">
        <property type="entry name" value="DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056457">
        <property type="entry name" value="DOP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007249">
        <property type="entry name" value="DOP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056458">
        <property type="entry name" value="TPR_DOP1_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042">
        <property type="entry name" value="DOPEY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042:SF24">
        <property type="entry name" value="PROTEIN DOPEY-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24598">
        <property type="entry name" value="DOP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04118">
        <property type="entry name" value="Dopey_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24597">
        <property type="entry name" value="TPR_DOP1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DOP1 N-terminal" evidence="8">
        <location>
            <begin position="36"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like middle TPR" evidence="9">
        <location>
            <begin position="395"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like C-terminal" evidence="10">
        <location>
            <begin position="1360"/>
            <end position="1825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1063"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL30171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1850" mass="205547" checksum="714B20940031B71F" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PV08</accession>
    <name>A0A0G4PV08_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S042g000038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793175">
        <property type="protein sequence ID" value="CRL29979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PV08"/>
    <dbReference type="STRING" id="1429867.A0A0G4PV08"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008699">
        <property type="entry name" value="NDUFB8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE ASHI SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05821">
        <property type="entry name" value="NDUF_B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL29979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="153" mass="16801" checksum="3A0355246527B039" modified="2015-09-16" version="1">MLSQRILARRLPQVAARAIAPRASFSQIPALRAAEIDDPLQNNNYPNPPAVKRAHRDPHGGWWDAQEKRNFGEPVHEDNEILGVFSPEEYTHVTAGKGFFHLGCFVAAFLGLVGVVSLNYPDKPSVPKAYVDGLEKELGGPNALPAHKSGDKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVD8</accession>
    <name>A0A0G4PVD8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl transferase, family 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S048g000028</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793181">
        <property type="protein sequence ID" value="CRL30316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PVD8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PVD8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF2">
        <property type="entry name" value="MANNOSYLTRANSFERASE KTR5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL30316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="35" mass="4568" checksum="1E005B872EC4C9E9" modified="2015-09-16" version="1">MCRFYSGQFYKHPLLLKYEWYWRLEPEIKYFCDIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVV0</accession>
    <name>A0A0G4PVV0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S053g000031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793186">
        <property type="protein sequence ID" value="CRL30523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PVV0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL30523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="138" mass="15237" checksum="36DA1492ED041E30" modified="2015-09-16" version="1">MVRLGSDLHQLHITTIASCAAQYHLSTKLALRRVIHRVLRLDLTASTPPRHERRSVLRHAPLALGIYPVYPARLIRSDSCGVRRTGYNIMSNGMNGDCIDRDNCNALIFPSLASNAKRAILSAQAICPFVNTGGMDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVZ9</accession>
    <name>A0A0G4PVZ9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">hydroxymethylbilane synthase</fullName>
            <ecNumber evidence="3">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S055g000004</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Porphyrin-containing compound metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMBS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="3"/>
    <dbReference type="EMBL" id="HG793188">
        <property type="protein sequence ID" value="CRL30589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PVZ9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PVZ9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000005">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="entry name" value="Porphobilinogen deaminase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557:SF0">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobilinogen deaminase N-terminal" evidence="10">
        <location>
            <begin position="25"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobilinogen deaminase C-terminal" evidence="11">
        <location>
            <begin position="262"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL30589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="356" mass="38475" checksum="CF63C9FB688ABF81" modified="2015-09-16" version="1">MSLNPNGSQPQHETEEISSRDSSGLVVGCRKSELALTQARTIISELKQKLGPSPTFEIATSSVVGDADKQTPFILLSKQTGGSDVGKSLWTNGLEKDLAAGKVQFLIHCLKDMPTTLPPNFLLGAIPEREDCSDAVVMRSDSVFKSIDQLPPGSVVGSSSSRRRALVRRNWPHLEIQECRGNLDTRLAKLDAPDSPFSCILLATAGLLRLGLGHRITQRLEPTVFPYAVGQGALGIELSTDRQDILQIVQHVDHKPSRWRGLAERAMLRSLQGGCSSSIGVLSSFEPLKENDLAESAIDSGTLRLRATVIHIEGTSEISSEDVSTVQSDDDAEQLGNSVANMLLSKGVRDLLPQHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PW40</accession>
    <name>A0A0G4PW40_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S048g000044</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793181">
        <property type="protein sequence ID" value="CRL30332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PW40"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL30332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="217" mass="24743" checksum="713872D6F63A8C7F" modified="2015-09-16" version="1">MGQYWLVVSPSRREYTTQDFGGKLSELLFSSWPNILCDLIENEWAGTRLICIGDYLNPTDLPASIQQDNLHIYAESDVTSKSLSYGVVQEDFEQWSYEEEETATLSATQESVNRKNRVLRNLTTSQYVLEAKLQCGITLGHIVLMRISWSSESSTGIPGGEYLTKGDWAGHEFDIVDAGMLEVMDGEWEDVTEDTRDEVQDLWSGQFEKGWEFETRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PWT0</accession>
    <name>A0A0G4PWT0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S055g000023</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793188">
        <property type="protein sequence ID" value="CRL30608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PWT0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PWT0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="16"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL30608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="268" mass="27708" checksum="C1D863697E4AE2F4" modified="2015-09-16" version="1">MVVEHPNAVQPELAGKVALVTGGGRGIGAGIALELAKKGASVAINYASSSKTADGVVQEIQAQGVHGAAFQADLTNVDSIANLFRQVVAHFGQLDIVVSNAGTEKFVPLSETTLEDFNAVFDLNTRAQFFVAKNAYDHIQPGGRVVLMSSIAAGLGVPGHSLYAGSKSAVEGFTRCFAADFGKKRATVNAIAPAGVKSDMWLSNAWRYAPGCDQNSSIEEIEQALANGSPLGRCGVPADIGRIVAFLASPGGEWINGQILPCNGGANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PX20</accession>
    <name>A0A0G4PX20_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S057g000035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793190">
        <property type="protein sequence ID" value="CRL30713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PX20"/>
    <dbReference type="STRING" id="1429867.A0A0G4PX20"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="84" mass="9132" checksum="DEEB2590B9D7DBAF" modified="2015-09-16" version="1">MVELTVSQVAGIIAALVFVVQLLLPVILGALLTGILKPENNLTTWSVVSRFLHSSYWPNILGSDSVASRSVHRPVLAVIWSRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PX24</accession>
    <name>A0A0G4PX24_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent DNA helicase II subunit 1</fullName>
            <ecNumber evidence="5">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">ATP-dependent DNA helicase II subunit Ku70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">PCAMFM013_S069g000013</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20 26">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterodimer of Ku70 and Ku80.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ku70 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="5"/>
    <dbReference type="EMBL" id="HG793202">
        <property type="protein sequence ID" value="CRL31047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PX24"/>
    <dbReference type="STRING" id="1429867.A0A0G4PX24"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <keyword evidence="11 24" id="KW-0347">Helicase</keyword>
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        <location>
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            <position position="24"/>
        </location>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL31047.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="653" mass="72959" checksum="45E90E9435092801" modified="2015-09-16" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CRL31203.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="68" mass="7754" checksum="7A158C37F248B1CE" modified="2015-09-16" version="1">MAITSYFIDSDWVYRKVLLRFKPLYSIHTGSYLSSVLIETLVEHNIEDKVFGLTTDNVSNNKTLATAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PZ97</accession>
    <name>A0A0G4PZ97_PENC3</name>
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        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">PCAMFM013_S4Jg000019</name>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
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                <person name="Malagnac F."/>
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                <person name="Lacoste S."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="CRL31497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="204" mass="23233" checksum="45571B9B7C30F80F" modified="2015-09-16" version="1">MPPATAETLLADLSPQLDMFIRFLKADLTSTILEGNLVRGKTRRATELLAPGKNTKCWIQRLQEVHQWTNLALWEQDWLQRTGQNEPTPCSGSHRFGTMAPFIQEEGLPDNHNTKKALQHGRRLMRFEREFGHGITLLLLPVLSAFRSLSQAEEARTMEMLRDGNSAYVAHLAQSLARLRLNYQCIHGIYPGKLIRSSCLYFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NSQ0</accession>
    <name>A0A0G4NSQ0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">DNA topoisomerase</fullName>
            <ecNumber evidence="3 7">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S001g000085</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3 7"/>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NSQ0"/>
    <dbReference type="STRING" id="1429867.A0A0G4NSQ0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="4"/>
            <end position="151"/>
        </location>
    </feature>
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            <begin position="169"/>
            <end position="604"/>
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    </feature>
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    </evidence>
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    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="628" mass="71383" checksum="3610E0373922A476" modified="2015-09-16" version="1"> </sequence>
</entry>
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        <submittedName>
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            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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                <person name="Giraud T."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL17044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="82" mass="9511" checksum="209AC6157D6567C6" modified="2015-09-16" version="1">MTFSSKRNAYRHAKEVHDGVKWPCSLAEEKRCTLEFCDQDYNEGVDGRRTANRSSSMQKRLSIPINSRPRSITVHQVSHYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NTY6</accession>
    <name>A0A0G4NTY6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S001g000521</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NTY6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL17561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="58" mass="5948" checksum="4191CE8BC998DAB2" modified="2015-09-16" version="1">MAASGVYSRQHPLTPLLGARGSVGVFPACEFLPIGLGLNSSCPAPQRSLFSSAVQCLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NU04</accession>
    <name>A0A0G4NU04_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cystinosin/ERS1p repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S001g000523</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the laat-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NU04"/>
    <dbReference type="STRING" id="1429867.A0A0G4NU04"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034488">
        <property type="term" value="P:basic amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000009">
        <property type="entry name" value="PQ loop repeat family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF34">
        <property type="entry name" value="LYSOSOMAL AMINO ACID TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="134"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="406"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL17563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="439" mass="48326" checksum="9CDA882300FF660E" modified="2015-09-16" version="1">MSLPLLQNLLFGTLPDHCEPTSPFLTAVSSHLHICIPTPLAAISSILGTLSIVSWLFAQLPQIYKNYQVQSTSGLSIFFLVIWCLGDASNLVGALYTRQAGWQVVIASYYVLVDITLVFQFFWYTHYKARQNDSYNSPSHSHDSAPRDIIQGVPPPGDSDHQTPAPINVDNKHSEDKDVGFHAGSVLNSTRGQAASYSNEKLSSSRRSVRMGSSAQSPPFALPRTMLMASLLCAVLANAAPTDKPHPPISEAPREAIFEIIGRVFSWMSTILYLGSRPPQLYKNYQRKSTEGLSPLLFMAAFCGNLFYSSSLLTNPNAWSDFSPYGGGGWADSHGNDRLEWIGRATPFFLGAFGVLGLDGFMGVQFLMYGDGPEHEDDESFVSGDGDDPKRGRGRWRHVHGWMRGWIPSSSPRRESRESSVPQEAQALLGTERGQYGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NUM4</accession>
    <name>A0A0G4NUM4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S001g000735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NUM4"/>
    <dbReference type="STRING" id="1429867.A0A0G4NUM4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005194799" evidence="1">
        <location>
            <begin position="23"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL17775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="324" mass="33997" checksum="DAD27F82A9438B52" modified="2015-09-16" version="1">MIQLKPSTLALVLSLFVSSTLAEDGELSSSLVGCNEVSCPKEGSNDRCTVGDNTFLGIGLSRIPDVPSSLEGFSLIKGVNVSAALAGKDNDKATRPFKSFYYLGTPSDVETKDLSGCVVVFHDAPSKKFDGPELEGNHNGTDVRAASGTCSDVVDKTCIEKLTEKATKLAEEAGGNVCTTLERELKKVSFDECDGFAGTGSSLGNFTVQSLDGLNAVKNSSGCWPIQPKSDRLVEIANFTALKNYSAQALLDEAYKITPVLTLFARKGNSSLVNQTASQLTCLKVVTEDDPSDDENGSENTAVAVRASGFAAGIAVLAGIFALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NVB6</accession>
    <name>A0A0G4NVB6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S001g000996</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL18036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NVB6"/>
    <dbReference type="STRING" id="1429867.A0A0G4NVB6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL18036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="291" mass="32130" checksum="7A9FC30A308589DC" modified="2015-09-16" version="1">MSNPDDCTLQTCPLSDAYIQYQPNVAGNIVYLALFAILLIGQIGTGIVFRSWTFMVPMVVGLILEIIGYLGRILLHDNPFSFNAFLMYLTCLTIAPAFFTAGIYLCLGRIITVYGEEYSRLKPRTYTYLFVTCDLISLILQAAGGAITSIADEQTLRNTGVNIMIAGLVFQVASLLVFSILAIEYGVRVLRGRRLHSPTQERPASWMRRSFLLGLTSAVLTILIRSSFRVAELQGGFDSKLANDEIALMILEGAMVSIACICLTGLHPALLVGKNWRTPQAISRDIEMEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NVM5</accession>
    <name>A0A0G4NVM5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S002g000041</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NVM5"/>
    <dbReference type="STRING" id="1429867.A0A0G4NVM5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005940">
        <property type="term" value="C:septin ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14081">
        <property type="entry name" value="STKc_BRSK1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000394">
        <property type="entry name" value="Serine/threonine-protein kinase HSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.220">
        <property type="entry name" value="Fungal kinase associated-1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031850">
        <property type="entry name" value="Fungal_KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043024">
        <property type="entry name" value="KA1_sf_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16797">
        <property type="entry name" value="Fungal_KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="104"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="472"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="552"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="637"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="746"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="836"/>
            <end position="897"/>
        </location>
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        </location>
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            <end position="567"/>
        </location>
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            <begin position="576"/>
            <end position="587"/>
        </location>
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        <location>
            <begin position="605"/>
            <end position="617"/>
        </location>
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        <location>
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            <end position="669"/>
        </location>
    </feature>
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        <location>
            <begin position="938"/>
            <end position="950"/>
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        <location>
            <begin position="1070"/>
            <end position="1084"/>
        </location>
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        <location>
            <position position="133"/>
        </location>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        </source>
    </evidence>
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        <source>
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        <source>
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        </source>
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        </source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1257" mass="140590" checksum="619130D4331CA24D" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NVV1</accession>
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            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
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        <name evidence="16" type="ORF">PCAMFM013_S002g000106</name>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
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    </organism>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM 013</strain>
        </source>
    </reference>
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        <reaction evidence="13">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
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            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
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        </reaction>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
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        <location>
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            <end position="234"/>
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    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="410"/>
        </location>
    </feature>
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        <source>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL18236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="696" mass="77316" checksum="D04F9AE60469311F" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWM9</accession>
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    </protein>
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    </gene>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
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    <dbReference type="Proteomes" id="UP000053732">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004668">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009446">
        <property type="term" value="P:putrescine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007466">
        <property type="entry name" value="Peptidyl-Arg-deiminase_porph"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31377">
        <property type="entry name" value="AGMATINE DEIMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31377:SF0">
        <property type="entry name" value="AGMATINE DEIMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04371">
        <property type="entry name" value="PAD_porph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL18455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="413" mass="45483" checksum="E197BC97004064A3" modified="2015-09-16" version="1">MPPTNKTWHIQHRALAQQADKTKQYTCPAETSPHLATLLSFPSQRSTLPELHAATSNEIISLATTIAAFEPVRLHARPEDIQQAQSLLNDQTTTLPPRHLANITLIPAPTNHCWIRDTGPVYIRSADAADKTRYAIDFRFCEWGHKTTERIYGASVSSTAAKALETSPQYAEWPVMDDEAMRENTAFASVVLDLENANADAVADVVVRVQTDIRLEGGGIEIDGEGTFMATESSIIGDARNAGLSKGEIEAELGRLLGVSTFIWFPGRVGLDVTDVHVDAEARFVRPGVVVVCRPHEKAEKVHWEIYEEIREVLERSTDVRGRRFEVHDVVEPDPTCIKGDLAGEEEAPAASYVNFYFVNGGLVMPAFGDAEADAKAFELMKSLVPEREVHQVKVNALPRTGGVLHCVTQQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWP3</accession>
    <name>A0A0G4NWP3_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mannitol-1-phosphate 5-dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S002g000341</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>D-mannitol 1-phosphate + NAD(+) = beta-D-fructose 6-phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19661"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:61381"/>
            <dbReference type="EC" id="1.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the mannitol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWP3"/>
    <dbReference type="STRING" id="1429867.A0A0G4NWP3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008926">
        <property type="term" value="F:mannitol-1-phosphate 5-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019592">
        <property type="term" value="P:mannitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000316">
        <property type="entry name" value="Mannitol-1-phosphate 5-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00196">
        <property type="entry name" value="Mannitol_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023028">
        <property type="entry name" value="Mannitol_1_phos_5_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000669">
        <property type="entry name" value="Mannitol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013118">
        <property type="entry name" value="Mannitol_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013131">
        <property type="entry name" value="Mannitol_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002647">
        <property type="entry name" value="PRK02318.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002652">
        <property type="entry name" value="PRK02318.2-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30524:SF0">
        <property type="entry name" value="ALTRONATE OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30524">
        <property type="entry name" value="MANNITOL-1-PHOSPHATE 5-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01232">
        <property type="entry name" value="Mannitol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08125">
        <property type="entry name" value="Mannitol_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00084">
        <property type="entry name" value="MTLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannitol dehydrogenase N-terminal" evidence="8">
        <location>
            <begin position="4"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Mannitol dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="205"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL18471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="395" mass="43333" checksum="5983B06EF34AFE87" modified="2015-09-16" version="1">MEKKAIHFGGGNIGRGFVAEFLHTAGFEVVFVDVMDSIINALQDTKSYQVTEVSDEGESTKTITNYRAINSKTHESDVIQEIATASVVTCAVGPNILKFIAPVIAKGIDARTDATPLAVIACENAIGATDTLHQFIKDNTAQDRIGSMPDRARFANSAIDRIVPGQAPDSGLNVRIEKFYEWAVESTPFGEFGHPEIPAIHWVGNLEPYIERKLFTVNTGHATVAYHGYHAGKKTIAEALQDSRIRNIVRDVLQETASLIIDKHEISAAEQQEYVETIITRISNPYLEDTVERVGRAPIRKVSRKERFIGPAAQLAERGGKFESLMGSLEMALRFQNVEGDEESVELAKILKENAPADAAIRLTGLDRDHPLFPHVVKVVDGVQSDAKEAGQPHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NX18</accession>
    <name>A0A0G4NX18_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S002g000354</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NX18"/>
    <dbReference type="STRING" id="1429867.A0A0G4NX18"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF28">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="2"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL18484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="129" mass="13722" checksum="B3EA5E62104654E0" modified="2015-09-16" version="1">MSKLAVVVGATGTQGGSVVQAFLESGRYQVRGLTRNTNGIKARELGAQGVEVVRADLNDVESLISAFKDASVIYGVTDFFAPFITNGTQADKAQEAEEAQGRNIVQAAACTPTLEHFIWSTMPDTNLNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXD5</accession>
    <name>A0A0G4NXD5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S002g000575</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NXD5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL19040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="246" mass="27392" checksum="7BE5734663E6EE66" modified="2015-09-16" version="1">MASKPESGPSPAQGVGPLYRPDGEKPTATVSKEVSYENVHVLPQTPQLIALLTMIRDKRTSRADFIFYSNRIIRLLVEEGLNHLPVVEQSITTPVGRSYLGVKFEGKICGVSIMRAGEAMEQGLRDCCRSVRIGKILIQRDEETCMPKLFYDKLPTDIADRWVLLLDPMFATGGSATLAVETLIERGVPEHRILFLNLIASPSGVAEFAERFPKLRVVTSFIDQGLDEKKYIIPGLGDFGDRYYSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYA3</accession>
    <name>A0A0G4NYA3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S002g000829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NYA3"/>
    <dbReference type="STRING" id="1429867.A0A0G4NYA3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053228">
        <property type="entry name" value="Stereospecific_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37574">
        <property type="entry name" value="LIPASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37574:SF1">
        <property type="entry name" value="LIPASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195102" evidence="1">
        <location>
            <begin position="19"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL18959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="457" mass="49467" checksum="A50A18DE0012E29F" modified="2015-09-16" version="1">MRCHQVFRLIFFISVSLGNPVPSYTSKDAQDVPDIFNKLFNTSTSRTPFSKDIYQGLYQLESKISDIATGKINPVSTIEEGLSVLASIPHTNNRTILQNAIDIVSLGLVPTNIIDILNGITNHEINSIANNNTKDPSPRIHPTRSVWDAPYDIPEETLRSAIHIPPTFSYGKNNKIPILLVPGTADPAGSTYYFNYAKLFTENPHTDPVWVNIPGNSLGDIQSNAEYVAYAINYISGLSQRPIGVLSWSQGSLDVQWALKYWPSTRAAVSDFMAVSGDFHGTLVATLCALAKLFCPPAVQQQGYDTRFIRALRGEDGDSAFVPTTSVYSGNDVIVQPQSGGWASAALGDVRGVGVLNVQVQVACAGRAAGGSYSHSAMLVNPLAYALFVDALVHDGPGRLERIDLEAICGESIAPGLDMNDFLGMEAVSNVVGVLDVLLYGYHNGSEELPLRGYVHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYA4</accession>
    <name>A0A0G4NYA4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S002g000911</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WAPL family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL19041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NYA4"/>
    <dbReference type="STRING" id="1429867.A0A0G4NYA4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039874">
        <property type="entry name" value="WAPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022771">
        <property type="entry name" value="WAPL_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22100">
        <property type="entry name" value="WINGS APART-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22100:SF13">
        <property type="entry name" value="WINGS APART-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07814">
        <property type="entry name" value="WAPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Wings apart-like protein C-terminal" evidence="3">
        <location>
            <begin position="397"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="276"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL19041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="857" mass="93837" checksum="55C757FE8E037293" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYB3</accession>
    <name>A0A0G4NYB3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Amino acid transporter, transmembrane</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S002g000933</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL19063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NYB3"/>
    <dbReference type="STRING" id="1429867.A0A0G4NYB3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF692">
        <property type="entry name" value="TRANSMEMBRANE AMINO ACID TRANSPORTER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="405"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="477"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="539"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="565"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="596"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="226"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="105"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
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</entry>
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</entry>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL20015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="87" mass="9759" checksum="75321DFFE5C31B23" modified="2015-09-16" version="1">MNMGNAHAQDPHGPLMQITMGSNDGAKPFRAPKTDSLVPFRETHFPRFKDEFILVFIFLGFKMASLLTLRTFYHLICTLSVSGISSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P184</accession>
    <name>A0A0G4P184_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent RNA helicase DHH1</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">ATP-dependent RNA helicase dhh1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PCAMFM013_S004g000015</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P184"/>
    <dbReference type="STRING" id="1429867.A0A0G4P184"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17940">
        <property type="entry name" value="DEADc_DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000114">
        <property type="entry name" value="ATP-dependent RNA helicase DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000364">
        <property type="entry name" value="ATP-dependent RNA helicase DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 17 22" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="21">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="77"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="257"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="424"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="457"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="513"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00040210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CRL20075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="533" mass="59782" checksum="2BE56AA1ADD0DCE3" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P1G9</accession>
    <name>A0A0G4P1G9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Transcription elongation factor Spt6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S004g000063</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Histone H3-H4 chaperone that plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression. Essential for viability.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the SPT6 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4P1G9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09928">
        <property type="entry name" value="SH2_Cterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09918">
        <property type="entry name" value="SH2_Nterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2740:FF:000002">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.650:FF:000004">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.850:FF:000001">
        <property type="entry name" value="Transcription elongation factor spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3500.10:FF:000005">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.140:FF:000007">
        <property type="entry name" value="Transcription elongation factor SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000056">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000065">
        <property type="entry name" value="Transcription elongation factor SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P598"/>
    <dbReference type="STRING" id="1429867.A0A0G4P598"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034088">
        <property type="term" value="P:maintenance of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019128">
        <property type="entry name" value="Dcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13395:SF6">
        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN DCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13395">
        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN DCC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09724">
        <property type="entry name" value="Dcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL21485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="396" mass="43813" checksum="A39A6E1A5F922B1E" modified="2015-09-16" version="1">MSTQESRGILFTHTRPQEGFRLLELTPELEDLLTSKDAPVLELKSPSTALAQAVIDPTAHDYVNLCTPTQTYRIRQVQSSNSLHILRPSRGEISQEDIKVVEEEPGESGALNLPDEAVTTISKCSSTLELHIPPGGFSAIPFLEKSLRLYDRRSDDDGDIAMGGSADPTAPLGSNEMRTARKNVCQDIPVSTAQCEQGWMELCAFVDGAEEVACWRPSPRSRLAVWKRLVEGAVLQGIDLEKQFLVGDLWKSVLDDDEEMEPPFPRALLEAVVRRICIADERPPLSDDIKWASFDKVECTQWVGETYLAATAPTTSSAIGRSELLRAWKDCLPETWRGEVALSKLPNGCYNSPDPTTICFVEPSQRQPANKTASAPTTAAKAKNTRNWHELLKGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5S4</accession>
    <name>A0A0G4P5S4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Flavin-containing monooxygenase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S006g000213</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P5S4"/>
    <dbReference type="STRING" id="1429867.A0A0G4P5S4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF2">
        <property type="entry name" value="FAD-BINDING MONOOXYGENASE AUSB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL21673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="645" mass="72431" checksum="D60720C1803B7B43" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5V4</accession>
    <name>A0A0G4P5V4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5'-deoxynucleotidase</fullName>
            <ecNumber evidence="8">3.1.3.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S006g000199</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HDDC2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="8"/>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P5V4"/>
    <dbReference type="STRING" id="1429867.A0A0G4P5V4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009159">
        <property type="term" value="P:deoxyribonucleoside monophosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3210.10:FF:000011">
        <property type="entry name" value="HD domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845:SF13">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0170">Cobalt</keyword>
    <keyword evidence="10 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="13">
        <location>
            <begin position="53"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CRL21659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="212" mass="23865" checksum="7E4A400505643A3B" modified="2015-09-16" version="1">MASDNSTWTPETVLSTLPYRPEENSTSPIPFFHLIQRLKTTKRAGWCRFGIENGESISDHMYRMSIMTMMAPPSVAKEVNIPRCIKMALIHDMAEALVGDITPADPVTKPEKARREASVMDYITTTLLGKVPGGVLSGKEIKEIFEDYEANTSKEAEFVHDIDKIELLLQMVEYERSSGIDLTEFTHVKGKIQSGPMKEWADKVMEGRPKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5X5</accession>
    <name>A0A0G4P5X5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S006g000270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
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                <person name="Dupont J."/>
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    </evidence>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Renault P."/>
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    </evidence>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195456" evidence="1">
        <location>
            <begin position="24"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL22303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="88" mass="9897" checksum="ACE5B47F03E71E6F" modified="2015-09-16" version="1">MFSITTIILGLFYLLLFTDVGTCKPITEDQDITVLFQNDGNWTTHADKSSAILVLNPSNRKDAVDTCASYGEELLDCKYLSAFYHQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7Y8</accession>
    <name>A0A0G4P7Y8_PENC3</name>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL22845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="118" mass="13692" checksum="762279292219BA9A" modified="2015-09-16" version="1">MAQPQPRRFAQIVHLKPSAVAAYKECHANVWPEILQKIKECNIVDYSIYFDNDRTLFATFKYVGTDIEADMENMRSLPKMREWWAMTDEMQESPIPGAVGSAEGPGWWKPLEEVFHTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P9M6</accession>
    <name>A0A0G4P9M6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose-methanol-choline oxidoreductase, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S008g000447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL23018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P9M6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL23018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="56" mass="6295" checksum="87A4D82378FFAD22" modified="2015-09-16" version="1">MTENPKTRIGGVILSDARRFDARKEVLLAASTLRTPHILRLSGIGPRNYLSMLFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAG7</accession>
    <name>A0A0G4PAG7_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Indoleamine 2,3-dioxygenase</fullName>
            <ecNumber evidence="5">1.13.11.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S009g000235</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Produces N-formyl-kynurenine through the oxidation of tryptophan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-tryptophan + O2 = N-formyl-L-kynurenine</text>
            <dbReference type="Rhea" id="RHEA:24536"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.52" evidence="5"/>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PAG7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PAG7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.480:FF:000005">
        <property type="entry name" value="Indoleamine 2,3-dioxygenase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF3">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL23295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="496" mass="56351" checksum="6507FE7489D2589C" modified="2015-09-16" version="1">MTRTQVPYPSPTTLKRFPHIHDDPSSISHSLDPFTITTKTGFLPYETAPVELPEAFSALLSLVNRLPVVRLDGKPGLLATYELGPAVKAELTDLTDEVEKLVLADGSHDRFTIAAIFRDYTFLASSYLLEPCWEHWNNDPEGGYGLGRDVLPQSVARPMYRCAEILNLPPFMSYAASYALFNYTVADPAKGLSEYSNLRLIRSFEKGLDPKSSEAGFILTHVDMVKETGPLIGGVLKIVDSLEQHGPRQEINDGFREILKSMEKIEASMEDMWGNSKPSEYLSFRVFIFGITNQSMFPNGVVYEGCEDNKPLYFRGESGANDSIIPLLDHLCEIPMPETPLTEILHEFRAYRPLPHREFLTYIREKSEEIGVQKYAIQDSETAVLFLRTLNHIRSFRWRHWLFAREYIIRRTPHPTATGGSPIVTWLPNQLSAVMELMVKIYDDNLAPKDGVAVVNGNEDLIASHRKQVEPMMELVRDQKEKLAREVERWCQERGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAX1</accession>
    <name>A0A0G4PAX1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S009g000385</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PAX1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PAX1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06225">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1530:FF:000001">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1530:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1530">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.500">
        <property type="entry name" value="HAMP domain in histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18947">
        <property type="entry name" value="HAMP_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL23445.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
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</entry>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
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</entry>
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        <alternativeName>
            <fullName evidence="7">Sulfur metabolite repression control protein B</fullName>
        </alternativeName>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Lacoste S."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
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        <property type="match status" value="2"/>
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        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
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    <keyword evidence="5 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="11">
        <location>
            <begin position="110"/>
            <end position="156"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
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            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="755"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="759"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002730"/>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00032113"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL23633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="822" mass="91559" checksum="A4A69F2756486196" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBQ5</accession>
    <name>A0A0G4PBQ5_PENC3</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PCX8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040023">
        <property type="entry name" value="WBP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173:SF10">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="U1-type" evidence="5">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="26"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="137"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="215"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL24104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="289" mass="32641" checksum="BB01B3183322F26C" modified="2015-09-16" version="1">MSEFWKSAPRYWCKQCKIFIRDTPFEKTQHEASPKHQGSLKRFLRQIHNDNEQKQRDSQRAKSEVERLRQAVSGEPSTDKDSAKGKAPPAPKFTERPASLEERKKQMAQLVAMGVAVPQEFRADMALAGDWETTSETRIDAKQGLEGPTKSVGIRKRKLEGEEEGDEHAPEPIVNKGWGSRMRQYPGAQEEEGLDDLFASTKDIKRTKTFVPKVELDDQETVAQQPIPTAKTEDVPPKPEIQETNESIVVKTEEPAQSAVEPVIEEKPQSEDAAPGVVFKKRKPKAMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PD57</accession>
    <name>A0A0G4PD57_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aromatic-ring hydroxylase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S011g000255</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PD57"/>
    <dbReference type="STRING" id="1429867.A0A0G4PD57"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000115">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF307">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="11"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL24261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="430" mass="47672" checksum="E737BDD72E8D72E9" modified="2015-09-16" version="1">MEIPRANVPLEVIVVGAGIGGMAAALTLGLRGHHVIVLESAPKLMEVGAGIQVSPNMLRLFDRWGVSDLIHAQDVALEHIHVRRWDDGRLLGTMPVNKTFGQQVVIHRADLHNAIIDRALALPNVELRENSHVTDVQFSPASVSLANGEIMRGDVVIGADGIKSTIRDHLLEDSTIKAVATGDAAYRIMLPRHIMDEDPELKKLIDEPQATRWLGPERHIIAYPVRKHELYNVVLLHPDGHGVEESWTTKGSKQAMVDNYDGWDSMVRKIIDLVDENEVLEWKLCLHRPLKTWIRGSVALIGDACHPMLPYVAQGAAQAVEDAAALGVVLSAISSREEIPHALNVYERSRKTRAETVQQSGSENRITLHLPDGPEQIARDAQFEASVSGNNPDKWSDRRTQEFLWGWDAEKAALNTWNEDQGQIRADANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PE37</accession>
    <name>A0A0G4PE37_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S012g000187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PE37"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL24577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="117" mass="13156" checksum="8D388D61323E70B5" modified="2015-09-16" version="1">MAVNVGLAIGLSMGLGIPLTVALIILAVTYGRRRHPRLPKPDACETQATENWLNLYHATRPRIKHPPKLFLSIVADRNLAESFLEKIRSILESLRLLRKPVVQEVYMMEDGAKVSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-11-27" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PE99</accession>
    <name>A0A0G4PE99_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospholipid methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S012g000248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PE99"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF15">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL24638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="38139" checksum="DBBFE505BAA41A7C" modified="2015-09-16" version="1">MTFFIPPSALEHQASSSLHSPPLKNKITPADVGILKSTLLPSFGLYSSLSLATYIAAEATNRVELKDWLWPSAQVLNAWWTAVGQPMCTHDISFRTACEALPWTKRVLLSCVTIWGTRLFARIACRSLSRGTDDARYDAIKKEPGFWRSAFLKIFLPEAVVLSVISLPFTVPFTTGDATVPMGDDVMNVVRALGVALFGAGFAMEVMADTQLGLHRQERTDLCRHGVWGLVRHPNYLGDTLVHFSFALLNMGGPFNPVVILGPVANYLFLRFVGGDKETESSQEERYKSQDPHKYEQLRQWKREKNSFWPELGDLVNPWALAVAGCGFIGVVIEEGLRGAYDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGD8</accession>
    <name>A0A0G4PGD8_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA primase large subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S014g000253</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic-type primase large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PGD8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PGD8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07322">
        <property type="entry name" value="PriL_PriS_Eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.80:FF:000003">
        <property type="entry name" value="DNA primase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058560">
        <property type="entry name" value="DNA_primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016558">
        <property type="entry name" value="DNA_primase_lsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007238">
        <property type="entry name" value="DNA_primase_lsu_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537:SF3">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04104">
        <property type="entry name" value="DNA_primase_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26466">
        <property type="entry name" value="DNA_primase_lrg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009449">
        <property type="entry name" value="DNA_primase_large_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA primase large subunit C-terminal" evidence="11">
        <location>
            <begin position="348"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="499"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR009449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR009449-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL25357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="551" mass="63359" checksum="3FAD5E78EB8F07B7" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGH7</accession>
    <name>A0A0G4PGH7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S015g000017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793148">
        <property type="protein sequence ID" value="CRL25431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PGH7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL25431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="56" mass="6022" checksum="6FB3C163D1CE40AA" modified="2015-09-16" version="1">MGAAVLLGPLLLDPGLIILLSEMAESPHKIPLPDLRTNMSHSTTPVKASYSPRNRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGN0</accession>
    <name>A0A0G4PGN0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S015g000095</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793148">
        <property type="protein sequence ID" value="CRL25509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PGN0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PGN0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF77">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="117"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL25509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="725" mass="81201" checksum="8512A7848C6ECE2A" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PHD1</accession>
    <name>A0A0G4PHD1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable transporter MCH1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S016g000033</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793149">
        <property type="protein sequence ID" value="CRL25752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PHD1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17354">
        <property type="entry name" value="MFS_Mch1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF45">
        <property type="entry name" value="TRANSPORTER MCH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="173"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="500"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="529"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="574"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
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            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL25752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="606" mass="66772" checksum="CCD1B8999BC7DCC2" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PHX3</accession>
    <name>A0A0G4PHX3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S016g000291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793149">
        <property type="protein sequence ID" value="CRL26010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PHX3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL26010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="260" mass="29284" checksum="58D35547E6CFECE1" modified="2015-09-16" version="1">MQKQNREVQTPTDIPGKSELTAPETYSTAPSSHRGLTSEQSATASNTTFSSRVKVNKAKETKNAEEEAEEEEILSSEGTWMALKAPKYPPKLPYVAIEEALNKLMLALDPPDTLVAQYFMLQGRLWLAKLWMPTLAQHLIGQRVTITDANGKDKQVQLKPYYSAPLSRFVINETNGILNETMDEQRFACSVGPKLRLVFEMPARVVKFKLLFGPSFQNSSMRLWPEDLEKPCHFSGATHSTNACPVVHRLDQTKWDIQCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJ54</accession>
    <name>A0A0G4PJ54_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Glucose-methanol-choline oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S018g000128</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJ54"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJ54"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF138">
        <property type="entry name" value="DEHYDROGENASE PKFF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195390" evidence="10">
        <location>
            <begin position="20"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="11">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="12">
        <location>
            <begin position="306"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="543"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="587"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="542"/>
            <end position="543"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="588"/>
            <end position="589"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL26435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="607" mass="66211" checksum="B01728336DAC90B5" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJ77</accession>
    <name>A0A0G4PJ77_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta hydrolase fold-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S017g000226</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793150">
        <property type="protein sequence ID" value="CRL26243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJ77"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJ77"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
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    </dbReference>
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        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="45"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL26243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="316" mass="35669" checksum="86C95E3E9F8434A5" modified="2015-09-16" version="1">MDKPAEKISFDDPRVQRRTATINGKTYGYLYAEPVHKYSRTIFLRGLRVVCPDCMGYGQSDSPTGSIVPFALKSQCEDFYLLAKQLGCEDIILGGHDWGSALASRFALYFPDFITHLILFVVPYFPPSPKYIAVNDLVKLQPSFGYMLQFGSEDGVIESHTQSKEGIRLFLNSLYGGLTQDGKKAITAASGIDFECLPRLSASKLLDEEEMNYYVNEFSRNGLRGPCNTYRVLHQNFLDDLPLLTGDPKKAAINCPTLFIRAMDDFAITSNMVDNMKAYVPHLTVEEVRSSHWIMVQRSQKVNDILEAWLQKQGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJH9</accession>
    <name>A0A0G4PJH9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S018g000274</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJH9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJH9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF37">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="530"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL26580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="622" mass="70412" checksum="4276A7E877E8EFD7" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJR3</accession>
    <name>A0A0G4PJR3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S019g000087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJR3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL26670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="180" mass="20998" checksum="92504D5EF9135268" modified="2015-09-16" version="1">MSSYRSINAIAQEIDRIRKSDPESTLYGVWNAILNFQFPVSDGYITRPQDEHTAQSGEKGYSDLHTFHYRENSSTADKFLIVQCKRAGYETRPSVWAEGVDQLCRYLSSTHGRRRRSARSPVYGIVAVGKHMRVYKYDDVSESVIDWSPNPRRLKKGKEWKLKEDYDEIQLILDHIRDNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PK34</accession>
    <name>A0A0G4PK34_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S019g000136</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PK34"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046623">
        <property type="entry name" value="DUF6536"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395:SF1">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20163">
        <property type="entry name" value="DUF6536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="526"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="599"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="662"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="705"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6536" evidence="3">
        <location>
            <begin position="107"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL26719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="805" mass="88232" checksum="092D54B8C842B91A" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKF2</accession>
    <name>A0A0G4PKF2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATPase, V0 complex, subunit E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S019g000085</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the V-ATPase e1/e2 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKF2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PKF2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008389">
        <property type="entry name" value="ATPase_V0-cplx_e1/e2_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05493">
        <property type="entry name" value="ATP_synt_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL26668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="75" mass="8518" checksum="4C893329D28567FD" modified="2015-09-16" version="1">MANGWSLVIGLIIIIAFSTAAWFLSPKGDNQTLFRSTLILTFVSCYLMWAIVFLAQWHPLIAPKRSDIRPDRVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKM0</accession>
    <name>A0A0G4PKM0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Molybdopterin cofactor biosynthesis C (MoaC) domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PCAMFM013_S019g000163</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:49580"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.6.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>GTP + AH2 + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + L-methionine + A + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49576"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.1.99.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the MoaC family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the radical SAM superfamily. MoaA family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKM0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PKM0"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01420">
        <property type="entry name" value="MoaC_PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21117">
        <property type="entry name" value="Twitch_MoaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.640">
        <property type="entry name" value="Molybdopterin cofactor biosynthesis C (MoaC) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01225_B">
        <property type="entry name" value="MoaA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013483">
        <property type="entry name" value="MoaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040064">
        <property type="entry name" value="MoaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010505">
        <property type="entry name" value="MoaA_twitch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023045">
        <property type="entry name" value="MoaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047594">
        <property type="entry name" value="MoaC_bact/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036522">
        <property type="entry name" value="MoaC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050105">
        <property type="entry name" value="MoCo_biosynth_MoaA/MoaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002820">
        <property type="entry name" value="Mopterin_CF_biosynth-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02666">
        <property type="entry name" value="moaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00581">
        <property type="entry name" value="moaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006870">
        <property type="entry name" value="PRK09364.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22960:SF0">
        <property type="entry name" value="MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22960">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SYNTHESIS PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01967">
        <property type="entry name" value="MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06463">
        <property type="entry name" value="Mob_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01383">
        <property type="entry name" value="cyclic_pyranopterin_phosphate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01386">
        <property type="entry name" value="main_SPASM_domain-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01067">
        <property type="entry name" value="SPASM/twitch_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55040">
        <property type="entry name" value="Molybdenum cofactor biosynthesis protein C, MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="16" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Radical SAM core" evidence="19">
        <location>
            <begin position="70"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="458"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CRL26746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="653" mass="72549" checksum="760ABF0AAD0BFC25" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKR2</accession>
    <name>A0A0G4PKR2_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Polyadenylate-binding protein</fullName>
            <shortName evidence="14">PABP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PCAMFM013_S020g000093</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation. In the nucleus, involved in both mRNA cleavage and polyadenylation. Is also required for efficient mRNA export to the cytoplasm. Acts in concert with a poly(A)-specific nuclease (PAN) to affect poly(A) tail shortening, which may occur concomitantly with either nucleocytoplasmic mRNA transport or translational initiation. In the cytoplasm, stimulates translation initiation and regulates mRNA decay through translation termination-coupled poly(A) shortening, probably mediated by PAN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the polyadenylate-binding protein type-1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CRL26934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12378">
        <property type="entry name" value="RRM1_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12379">
        <property type="entry name" value="RRM2_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12380">
        <property type="entry name" value="RRM3_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12381">
        <property type="entry name" value="RRM4_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1900.10:FF:000004">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000003">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000355">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000384">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.10">
        <property type="entry name" value="c-terminal domain of poly(a) binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036053">
        <property type="entry name" value="PABP-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006515">
        <property type="entry name" value="PABP_1234"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002004">
        <property type="entry name" value="PABP_HYD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034364">
        <property type="entry name" value="PABP_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045305">
        <property type="entry name" value="RRM2_I_PABPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01628">
        <property type="entry name" value="PABP-1234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00658">
        <property type="entry name" value="MLLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00517">
        <property type="entry name" value="PolyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63570">
        <property type="entry name" value="PABC (PABP) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51309">
        <property type="entry name" value="PABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 13 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="43"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="131"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="224"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="327"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="PABC" evidence="17">
        <location>
            <begin position="634"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="358"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="604"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="710"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="375"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="604"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="623"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CRL26934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="736" mass="80051" checksum="DE2A4BD4CD8F7559" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PL62</accession>
    <name>A0A0G4PL62_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S020g000050</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CRL26891.1"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
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        <property type="entry name" value="Fun_TF"/>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
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        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
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        <property type="entry name" value="Fungal_trans_2"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="39"/>
            <end position="69"/>
        </location>
    </feature>
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        <location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="453"/>
            <end position="480"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL26891.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="605" mass="68324" checksum="CC43192221F9438F" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
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        <name evidence="23" type="ORF">PCAMFM013_S020g000227</name>
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    <organism evidence="23 24">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
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    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
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            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
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        <reaction evidence="25">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
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            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
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            <dbReference type="ChEBI" id="CHEBI:140395"/>
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        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the RNA polymerase beta chain family.</text>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
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        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
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        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
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        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb2_3"/>
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        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
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        <property type="entry name" value="PRK09606.1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb2_2"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
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    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14 23" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="19">
        <location>
            <begin position="37"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="286"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="20">
        <location>
            <begin position="501"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="600"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="22">
        <location>
            <begin position="704"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="16">
        <location>
            <begin position="782"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="1156"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CRL27068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1256" mass="141611" checksum="3FC26B0B672A5989" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PLR4</accession>
    <name>A0A0G4PLR4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DUF1640-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S021g000033</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CCDC90 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793154">
        <property type="protein sequence ID" value="CRL27118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PLR4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PLR4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000018">
        <property type="entry name" value="Mitochondrial protein FMP32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024461">
        <property type="entry name" value="CCDC90-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360:SF1">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07798">
        <property type="entry name" value="CCDC90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="19"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL27118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="34620" checksum="62195FF6040EDB15" modified="2015-09-16" version="1">MAPQKHVADVPRNILPRLTWNSSSSRPSVTVTHHPALATSQRRPLPQAWSPVKRRFSSLTPPSQSSQLISTSSRDAISGYLVSRGTSITTPATSNTTPRGNPIRHNGVYVATYHPARRAFHATPVRPRDHHFDTLKFVKRLQAEGFSEEQSVAMMRVLNDIIQESIQNLTRTMVLREDSERSTYTQKVDFAKLRSELLNADSTEAQLTRSSHEKIAADLAKLNSRLRDEIGRTQASVRLDLNLEKGRIREEANSQEMRIKETETRIEQEVAGLRERVEAVKFSTLQWLMGVCTGTAALILGAWRLFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PLV4</accession>
    <name>A0A0G4PLV4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ras small GTPase, Ras type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S021g000081</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793154">
        <property type="protein sequence ID" value="CRL27166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PLV4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PLV4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01870">
        <property type="entry name" value="RhoA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000329">
        <property type="entry name" value="GTP-binding protein rhoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL27166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="198" mass="22029" checksum="5DFB1F8210FBE262" modified="2015-09-16" version="1">MAEIRRKLVIVGDGACGKTCLLIVFSKGTFPEVYVPTVFENYVADVEVDNKHVELALWDTAGQEDYDRLRPLSYPDSHVILICFAVDSPDSLDNVQEKWISEVLHFCQGLPIILVGCKKDLRDDRKTIDELAKTSQRPVSQDQGEEVRKKIGAYKYLECSARTNEGVREVFEAATRAALLKAVTGKGGRKPGKGCLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PLY6</accession>
    <name>A0A0G4PLY6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Disease resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S022g000019</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793155">
        <property type="protein sequence ID" value="CRL27339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PLY6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PLY6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056681">
        <property type="entry name" value="DUF7779"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25000">
        <property type="entry name" value="DUF7779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="3">
        <location>
            <begin position="14"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="2">
        <location>
            <begin position="351"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7779" evidence="4">
        <location>
            <begin position="611"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="754"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="796"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="880"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL27339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="987" mass="109875" checksum="F5F7859516D67ADF" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PM07</accession>
    <name>A0A0G4PM07_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Trimethyllysine dioxygenase</fullName>
            <ecNumber evidence="5">1.14.11.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Epsilon-trimethyllysine 2-oxoglutarate dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">TML hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">TML-alpha-ketoglutarate dioxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PCAMFM013_S021g000133</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(6),N(6),N(6)-trimethyl-L-lysine + 2-oxoglutarate + O2 = (3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:14181"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:58100"/>
            <dbReference type="ChEBI" id="CHEBI:141499"/>
            <dbReference type="EC" id="1.14.11.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; carnitine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.8" evidence="5"/>
    <dbReference type="EMBL" id="HG793154">
        <property type="protein sequence ID" value="CRL27218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PM07"/>
    <dbReference type="STRING" id="1429867.A0A0G4PM07"/>
    <dbReference type="UniPathway" id="UPA00118"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050353">
        <property type="term" value="F:trimethyllysine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00250">
        <property type="entry name" value="CAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2020.30:FF:000002">
        <property type="entry name" value="Putative gamma-butyrobetaine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000001">
        <property type="entry name" value="Trimethyllysine dioxygenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012776">
        <property type="entry name" value="Trimethyllysine_dOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02410">
        <property type="entry name" value="carnitine_TMLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF51">
        <property type="entry name" value="TRIMETHYLLYSINE DIOXYGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0124">Carnitine biosynthesis</keyword>
    <keyword evidence="8 20" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-butyrobetaine hydroxylase-like N-terminal" evidence="19">
        <location>
            <begin position="78"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="TauD/TfdA-like" evidence="18">
        <location>
            <begin position="173"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00071191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CRL27218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="459" mass="53278" checksum="A8A63B9A265F9436" modified="2015-09-16" version="1">MNFSWRAALRSSELWSRGPKGLRPRYSPAGGLTGHRHATPGFSRLLNTQMGWSGPQIAWSRPDIVTFPGKDRKDREITFNFGRFFLRENCQCPKCIHPDTMQRTSDTFSIPQNVKIESIEHSDNIVKIKWSDKHTGLYSYAWLHAHSQKMSRIEGTKPVTYPKSAMQPPRQFTPVTDPDQTPRVKYDDVMSDDESLHVWLTHIWDQGFCFVDDVPVNPEATQFLIERIAFIRNTHYGGFWDFTADLTFKDTAYTNEFLGAHTDNTYFTDPARLQLFHLLSHTEGSGGENLLVDGFAAAAQLRLESPEDYAQLVNHRHPWHASGNEDTCIQPSAMAPVFSMHTDLNKMYQIRWNNYDRAPKTNWSALEQTVWYRAARHYNEILQSKEMWTKLKPGSALMFDNWRMLHGRSEFTGKRRMCGGYVNNDDYISRLRLLKFGRKEVLDNLGNVRNKPQNPYWFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMC8</accession>
    <name>A0A0G4PMC8_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1275 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S023g000040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793156">
        <property type="protein sequence ID" value="CRL27582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PMC8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488:SF8">
        <property type="entry name" value="DUF1275 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G13060)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL27582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="28750" checksum="3F0B87F054EFA101" modified="2015-09-16" version="1">MEKSEAPATPDLEAPDLPAKQSSVAQRWKQNLSPTHADLVCLLLTFLTGLCDSSAYNAWSCFLGMQTGNTIFLGLGASNQPNNKPWGWLKSLVSIASFFFGSMIFSIVMRSVGSLRRGTLFVSFFVQTILIIIAVALIEADLIPHTSSDATLTGGPLFLELIPIGLLAFQSAGGMTCSRALGYNEIPTVVLTSVYFDIASDPKITDKPNTNVKRNRRIGGVVFLLVGAIVGGWLSRSSGGMQSALWMAAGLKFIAAIGWLFWKAAPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNK6</accession>
    <name>A0A0G4PNK6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phytanoyl-CoA dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S024g000013</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793157">
        <property type="protein sequence ID" value="CRL27758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PNK6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PNK6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF48">
        <property type="entry name" value="ECTOINE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL27758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="269" mass="30184" checksum="BE6702891123F3BB" modified="2015-09-16" version="1">MNNFHYSLSAEQLQSFQECGYLLVRGFFTSEESELLREWAQEVHDLPCTPDVPWMPYQEVNLEGKRVLCRTENFANSHAGFDSFLRGQRATSLLQQLAGEEMLLFKEKINYKLAGSGGFDPHIDANAYTHVKNIKHLTILAAVDGMNAANGGLEVVNGSHRMDIPLGSDRCIASDWVESNVWTPAELESGDILIFGSYLAHRSGANVSSKDRRAIYATYNCAAEGNLHDQYYSDRQKLWPATHMRENGQSYEEGRARYAFGSPMLTVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPJ3</accession>
    <name>A0A0G4PPJ3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid/polyamine transporter I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S026g000174</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793159">
        <property type="protein sequence ID" value="CRL28309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PPJ3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PPJ3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000001">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF3">
        <property type="entry name" value="AMINO-ACID PERMEASE PB1C11.02-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="43"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL28309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="536" mass="58390" checksum="F079E191932FFCB1" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-11-27" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPN8</accession>
    <name>A0A0G4PPN8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily, general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S025g000184</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793158">
        <property type="protein sequence ID" value="CRL28126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PPN8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF31">
        <property type="entry name" value="HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="24"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL28126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="787" mass="88678" checksum="0523ADF1D29DB6BC" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQ25</accession>
    <name>A0A0G4PQ25_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heat shock protein Hsp70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S028g000008</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793161">
        <property type="protein sequence ID" value="CRL28455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQ25"/>
    <dbReference type="STRING" id="1429867.A0A0G4PQ25"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF79">
        <property type="entry name" value="HSP70 FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G15200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL28455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="703" mass="78175" checksum="52B99AF7B2E9EAA5" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQ27</accession>
    <name>A0A0G4PQ27_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fip1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S026g000131</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793159">
        <property type="protein sequence ID" value="CRL28266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQ27"/>
    <dbReference type="STRING" id="1429867.A0A0G4PQ27"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007854">
        <property type="entry name" value="Fip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051187">
        <property type="entry name" value="Pre-mRNA_3'-end_processing_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13484">
        <property type="entry name" value="FIP1-LIKE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13484:SF0">
        <property type="entry name" value="PRE-MRNA 3'-END-PROCESSING FACTOR FIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05182">
        <property type="entry name" value="Fip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA polyadenylation factor Fip1" evidence="6">
        <location>
            <begin position="162"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="286"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="288"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL28266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="335" mass="35817" checksum="3AB30800EC874FD0" modified="2015-09-16" version="1">MDEEEDDFYDPVDAVPTTQSLNHTQNAAPGQPQENNYMEDDDEVEEEEEDDDDFNIITEAPEGAPAPEASHPRHASLRQEPQRPSSADSSVLTSSATPSATPRHETATPIPGHPAAAGAAAARPSSEKPGSAYPAIHSSTIDVNANPIHPMTGKPIMSTDMDADFPSDDKPWRRPGSDLSDYFNYGFDEFTWAGYCLKQQGVRQEVGSQKRQMDDMQAFMGMGMPPMPSAPGPAAPASAAPPMAGMPGMPDMNPDMMQGMLASMMSQGLDPSNMDPMAFMQHAQSMMPGGGQQSQPGFGGQPQGQGFNQGGQGQMGYGGYDQRGGYGGRGRGRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQ89</accession>
    <name>A0A0G4PQ89_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Neutral protease 2</fullName>
            <ecNumber evidence="14">3.4.24.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Deuterolysin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S028g000117</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Secreted metalloproteinase that allows assimilation of proteinaceous substrates. Shows high activities on basic nuclear substrates such as histone and protamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>Preferential cleavage of bonds with hydrophobic residues in P1'. Also 3-Asn-|-Gln-4 and 8-Gly-|-Ser-9 bonds in insulin B chain.</text>
            <dbReference type="EC" id="3.4.24.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the peptidase M35 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.39" evidence="14"/>
    <dbReference type="EMBL" id="HG793161">
        <property type="protein sequence ID" value="CRL28564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQ89"/>
    <dbReference type="STRING" id="1429867.A0A0G4PQ89"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11008">
        <property type="entry name" value="M35_deuterolysin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050414">
        <property type="entry name" value="Fungal_M35_metalloproteases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001384">
        <property type="entry name" value="Peptidase_M35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016:SF3">
        <property type="entry name" value="NEUTRAL PROTEASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02102">
        <property type="entry name" value="Peptidase_M35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00768">
        <property type="entry name" value="DEUTEROLYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
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        <ligand>
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                <person name="Dupont J."/>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR038994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL28413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="427" mass="45821" checksum="053F335BE56E76EE" modified="2015-09-16" version="1">MPGKTSTPRITKFTNCRLVCGLNLIEQDLWIDSLTGKILKDQEAFYGLHLSPDNIIDLGGRIIAPGMIDVQLNGAHGFDFSVPCETKEKYDEGLRVVNRGLARTGVTSYLPTLVSSTPEVYWKVLPSLGPTAGTHTPQDGAESLGAHAEGPFISPGRNGIHKPEVLRAAETFDDLVYCYGADNLGSASPIKMITAAPEVGNMMAHIPEIARRNIIYAIGHSDSTYEQGVAATHKGARMITHLFNAMRPFYHRNPGIFGLLGQSERRRPFYGVIADGIHLHPTSIKIAYNAHPDGLILVTDAMRLCGLPDGVYEWTNGERIVKTGARLTLEGSDKIAGSSATLIECVNNFRRWSGASTAAAINAVTATPARLLGLEGVKGSLQSGADADLIVLGESEDPFTGPTLTVDQVWKLGAKIHDTDKAATVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQK5</accession>
    <name>A0A0G4PQK5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger, Zim17-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S027g000095</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793160">
        <property type="protein sequence ID" value="CRL28406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQK5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PQK5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024158">
        <property type="entry name" value="Mt_import_TIM15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007853">
        <property type="entry name" value="Znf_DNL-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922:SF13">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05180">
        <property type="entry name" value="zf-DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51501">
        <property type="entry name" value="ZF_DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNL-type" evidence="6">
        <location>
            <begin position="94"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="63"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL28406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="201" mass="22888" checksum="178010EB82BDCFCA" modified="2015-09-16" version="1">MRSFTSGLRPLNALVSQAQSYTAVARTQSSRFLSTQSLSLHSARPSSLLPRSQRIFAQTQLRYNSRAPRPLTESPKSQAEQEAEWEAQNRERRKDEEAYRITFTCKPCGHRSAHRMSKQGYHRGTVLIQCPSCDSRHVMSDHLGVFFEEKTTLEDILKEKGQTLTHGHTEGNLEFWEDGSVKSYDLEGKEILGARKDDKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-11-27" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQT3</accession>
    <name>A0A0G4PQT3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S030g000099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793163">
        <property type="protein sequence ID" value="CRL28812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQT3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PQT3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF5">
        <property type="entry name" value="POTASSIUM ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL28812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="144" mass="16468" checksum="1FD80405CA49C985" modified="2015-09-16" version="1">MGDQSVLIYWRALVFMGKLADPWIITLSVLSLVIIYPYGNLKAVDAYFFGASASAESGLNTVDVKFLETYQQIYIYLILILGNLGFINMICYIDQASFLIWQRDSFCFRLFVLVDSKGLFNSDCFRLLYIKDLALGFSSTPHLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRM0</accession>
    <name>A0A0G4PRM0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial substrate carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S032g000093</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793165">
        <property type="protein sequence ID" value="CRL29057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PRM0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PRM0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000095">
        <property type="entry name" value="Mitochondrial carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="62"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="157"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="265"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="13"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="293"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="293"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
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</entry>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="281"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL29608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="318" mass="35752" checksum="D7F34BE1518354A2" modified="2015-09-16" version="1">MGLTATAKVVTRSEYYGKVFIESWFDGLPEDWRFEVSPNGWTSGEIGLRWLEKLFIPTTSSRTKGGYRLLILDGHGSHLSPNFDQICEENKIILICMPPHSSHLLQPLDIGCFAVLKRSYGRMVEMKMRNGINYIDKFDFLEAYPLARTEAFKSETIKNSFRAAGLVPFSPERVISKLDIRLRTPTPPPSSRGSEWDPKTPSNYVQLQKQASSIKALLPCQITMQSAALLEKEVSELRAANEKQKQKRTRSRRQMLAEESLSVQEASALIMQPVEVVEAPLPGPGIPGESALQPRTKPPRGCGICRKPGHRRETCPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PTY6</accession>
    <name>A0A0G4PTY6_PENC3</name>
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        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">PCAMFM013_S038g000019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793171">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL29616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="162" mass="18653" checksum="D8D457FBA9251EF5" modified="2015-09-16" version="1">MHESTKDSSLSAKNSVPIRLHTVRIWFHPNGLTLMEDIKRRGLDDVVFDAIALQELGDQHEAFLVDLAVLEVGISRVLGKYGITKFVPLSGDDPIILQQPVEDLDSKKALCYQHLHSKYLQEYAKRCKLGKVLGFEIHNVLKDWYKERLEDICNRFRKLGYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PU42</accession>
    <name>A0A0G4PU42_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S039g000003</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793172">
        <property type="protein sequence ID" value="CRL29694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PU42"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="4">
        <location>
            <begin position="114"/>
            <end position="172"/>
        </location>
    </feature>
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        <location>
            <begin position="231"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL29694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="390" mass="43604" checksum="4090E50E1694E02B" modified="2015-09-16" version="1">MAERRSAYRPCPTSRRQEHNPISSYEFPETGRPRWRPSDRAKLNLSTLEQKLHFVQLSNCSRIKDGWATSRYICSHSNQLKLATFRKTISNAWQEAKHRRRLRSGGSPLSQPAHTRTYEAVIKELSTELDEHLAPDEASRHRQQHDPNKLDEGEGVSLFKICVRQVANAMMLSNSDLVICCRCFGLAMAVSFGIQPWIEGEVICAVIVLNIIVGFFQVYASEKTMELLHSLSSPTGTVSRGGQTFSVPSSEIVPGDMVELRTGDTVPADIRYLNLVDTQTYAFVGPYFMMILRQSRAFQGGSPLKRPSTSWGRKASTVEISHQLEAHGGSSQDFQKCGEVPDEPLRKDYFPGEPRSSLLSEALASVIGVGHLDGVDGDSNARRGKKIRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVS1</accession>
    <name>A0A0G4PVS1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polynucleotidyl transferase, ribonuclease H fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S047g000002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793180">
        <property type="protein sequence ID" value="CRL30274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PVS1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PVS1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43040">
        <property type="entry name" value="RIBONUCLEASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43040:SF1">
        <property type="entry name" value="RIBONUCLEASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="1">
        <location>
            <begin position="60"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="300" mass="33255" checksum="C8F23B5E8FB7F727" modified="2015-09-16" version="1">MSTITAASLESARVLTPIPTTEQSQSPHAAVSVNLDQDALTSLTAAFQSSALEDKASVTFIDTCAGVAEMIGDLTHLPAKPPSLYIDLEGVNLSRHGTISILQIFVLPQRSTFLIDIYGLKDKAFSYPAPSGTTLRAILESPSIPKVFFDVRNDSDALFSHYQIELSGVQDLQLMELATRKFSKRCVNGLGKCIENDAGMTADERANWKAFKDKGRKLFAPECGGSYEVFNTRPLPDEIRQYCAQDVQFLPKLWQKYDGRMTRQWATKVEMEVKNRVRLSKSKTFNGKGRHMALAPANWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVT8</accession>
    <name>A0A0G4PVT8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S051g000029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793184">
        <property type="protein sequence ID" value="CRL30426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PVT8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PVT8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="535" mass="59378" checksum="319478A91B47017B" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PWE0</accession>
    <name>A0A0G4PWE0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-xylose reductase [NAD(P)H]</fullName>
            <ecNumber evidence="2">1.1.1.307</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S051g000045</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>xylitol + NAD(+) = D-xylose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>xylitol + NADP(+) = D-xylose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27445"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.307" evidence="2"/>
    <dbReference type="EMBL" id="HG793184">
        <property type="protein sequence ID" value="CRL30442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PWE0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PWE0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="9">
        <location>
            <begin position="58"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="9">
        <location>
            <begin position="141"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL30442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="320" mass="35972" checksum="CE546E47F5540AFA" modified="2015-09-16" version="1">MANSRSMILRWSIFSFGALVAFVVMVNLFQQYQPFLATSGKNYEAEYKTTPLLYIPPLGLGTWQIPKSKASAVVKFAIEKGYRHIDAALIYGNEKEVGEGIVQSGIPRSFLWVTGKIWNDAHEPSSVLAFKPDTGHKDVNDNVNLLETWWAMEELVKEGLVRQIGVSNFNQAQVEQILRHARVRPSVHELETHPYLQQIAFVNWNLARGLRVIAYSPLGNMNPINNSSDTPLLQEPSLISLARKNGITVAQLAPSWGMHRGIVVIPKSEHEDRVLENLQAQHVRLADDDFQAINAYDRKTRFNNPSGIWGVQLYTGLDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PWF6</accession>
    <name>A0A0G4PWF6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Polyprenyl synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S057g000004</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HG793190">
        <property type="protein sequence ID" value="CRL30682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PWF6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PWF6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045337">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00867">
        <property type="entry name" value="Trans_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL30682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="222" mass="25812" checksum="8B63BD3899D650D5" modified="2015-09-16" version="1">MLEAGIYLIPKQCFRSHPAYIDIFELFHERTWQTDLGHLCDRITAPEDIFNFDNFPIKYMFLVTYKTAHCSFYLPVALAPMYLQLATEETLKQAHDILIPLGQYFQIQVDYFDNLGNPSVIGKIGNDIQDNKCSWLVNQVIQRCTLEQRQLLDASYGRKGAAEAKVKALFNELFFQLEKVYKKYEERVVGELHEKIAAAHESKGLEKKVFEAFLGKIYKRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PWG1</accession>
    <name>A0A0G4PWG1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc finger, CCHC-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S053g000022</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793186">
        <property type="protein sequence ID" value="CRL30514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PWG1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PWG1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="292"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="63"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL30514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="357" mass="40060" checksum="65A93668869DAAEF" modified="2015-09-16" version="1">MVSRKYQFTGEDLATRVNVENRKRTRSGDAFSPSDPAGRITTKEVWKLIGTLKDVIHHQTATIAATQQELQEIKHNQHILQEQKEKLHDEVKALRTQIETKPPATATKTWAAVAAESGNSSSLVNPQRPERDQDCVRISTQRAFSDTATQDTQVAGIGTTKTGYIIRFKSTESAEVARSNTEWLHKLGNNTRLVKPRFEVVVHRTPTEEFDIETGVAQAAEKIIAENDLADHSFHIEGLAWIKAKDKTLGKSASLGIWFGSPEGVEYMLRKGFLVSGQLITSVERREIKKKRCFRCQRFGHLAWSCKETPRCGHCAGQHERERCLPGVRARCLDCSGEHPTGDRECPTPSTSNLTRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PWS9</accession>
    <name>A0A0G4PWS9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S056g000023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793189">
        <property type="protein sequence ID" value="CRL30650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PWS9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="68" mass="7630" checksum="B303D00F04AB9546" modified="2015-09-16" version="1">MVHFQEAERGLAIFQSGVEDRALELSQKRHTSSPGAHQGFSPSQMFARSGWKKDTGKERGRSEGENRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PXE1</accession>
    <name>A0A0G4PXE1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S067g000006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793200">
        <property type="protein sequence ID" value="CRL30998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PXE1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL30998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="121" mass="13877" checksum="89CCB7533628000D" modified="2015-09-16" version="1">MTNSPFGDDAYQPRTVDLWDENSQYAPTPGNFGRIPATLYSPSRPSDCATEQLHSDQPSGLLYKIFEGSLRHTFPVSYFPSYYMAFNFFYEYDPRKHRQVRLDPCPISIVFSMSVRCALGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PXT1</accession>
    <name>A0A0G4PXT1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S064g000013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793197">
        <property type="protein sequence ID" value="CRL30939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PXT1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PXT1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="118"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="205" mass="23047" checksum="A4C869CADD5E2CA2" modified="2015-09-16" version="1">MSKSSNEKRFKLRKQCREALAAHIYDRLRLVVAPERVRLQPRPKDRYAWSVARTNTSLLKSSLSSGSTSLYQLICRELGRSLEAVNPQSYNTGGLPKEGMKVQDLGEGVVDGSFTVEISELKATNSRIKEELGRTRSRLDNSLRESHTLRAEANELRHDLQILESQNKNMHDELVQKRVGIAGAMQTLSSLQTEGIEITLDTHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PYA5</accession>
    <name>A0A0G4PYA5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S127g000003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793258">
        <property type="protein sequence ID" value="CRL31348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PYA5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL31348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="54" mass="6349" checksum="AC3E7330B1C62B80" modified="2015-09-16" version="1">MLYQFATNFDLRYKELGIIKEYLSQGEAALLDQTRRSLLQLEVLEPISNNEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PYF8</accession>
    <name>A0A0G4PYF8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S086g000002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793217">
        <property type="protein sequence ID" value="CRL31201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PYF8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PYF8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF438">
        <property type="entry name" value="REVERSE TRANSCRIPTASE TY1_COPIA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL31201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="170" mass="18855" checksum="99F05651CB1DBF3E" modified="2015-09-16" version="1">MHDLEPALQFASDASFGDHTDRKSSEGYLCRLFGGAVDWKAGKQKTVTTSTTEAELLALSEAAKSALWWKRLLAAVNLVYQNSEAMEIQCDNAQTVGLLTKETPQLSTKLRHVDIHNHWLRQAVQAGEIAIRWVSTKDMAADGLTKLLPTQNHSNFMRALGLTSIQHLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PYG4</accession>
    <name>A0A0G4PYG4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S147g000001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793277">
        <property type="protein sequence ID" value="CRL31372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PYG4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL31372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="54" mass="5844" checksum="AC2385B50390F2B4" modified="2015-09-16" version="1">MSSTRGDTTAILGKVRRCSKNGSLDDFLPMYGLTEDIPVTEVIDASPGKLCYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PZD5</accession>
    <name>A0A0G4PZD5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S4Jg000064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793313">
        <property type="protein sequence ID" value="CRL31542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PZD5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL31542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="158" mass="17881" checksum="450E88CAA6BD6666" modified="2015-09-16" version="1">MARIPNRSATYEEVRIYIAQTLISKYNAGHDFAEDTARSWRLGRGSELYDAKLEYFQEVFGMDTGLCLFQSVCEDRDNAWKQSVIGVICFWMTIVSAALLFWFHILPLLRGQTGSPSQLLLFGLTRAIYAYLSPRRDDYMLVSGLFSACIALVAATRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-11-27" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NSY5</accession>
    <name>A0A0G4NSY5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M49, dipeptidyl-peptidase III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S001g000044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NSY5"/>
    <dbReference type="STRING" id="1429867.A0A0G4NSY5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039461">
        <property type="entry name" value="Peptidase_M49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422:SF11">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE III-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03571">
        <property type="entry name" value="Peptidase_M49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL17084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="701" mass="78935" checksum="189F28916EA563F3" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NT24</accession>
    <name>A0A0G4NT24_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Crh-like protein</fullName>
            <ecNumber evidence="16">3.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PCAMFM013_S001g000192</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Dual chitinase/transglycosylase that plays a role in cell wall architecture. Chitinase and transglycosylase activities are coupled. Required for the polysaccharide cross-linking at the septa and the cell wall. More specifically, transfers chitin to 1,6-beta-glucan in the cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.-.-" evidence="16"/>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NT24"/>
    <dbReference type="STRING" id="1429867.A0A0G4NT24"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000159">
        <property type="entry name" value="Glycosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017168">
        <property type="entry name" value="CHR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF22">
        <property type="entry name" value="GLYCOSIDASE CRH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037299">
        <property type="entry name" value="Glycosidase_CRH1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="21" id="KW-0430">Lectin</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 19" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005194774" description="Crh-like protein" evidence="19">
        <location>
            <begin position="20"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="20">
        <location>
            <begin position="26"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="345"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="369"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="17">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="17">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00093308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR037299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CRL17232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="431" mass="45845" checksum="2388F1E4163B15EC" modified="2015-09-16" version="1">MVRFVTPLVLASLSVSAFAAQSCSSSSQCNEKYPCCSQYGECGTGAYCLGGCDPLASFSLDSCAPMPVCESKTYTWDNLDNAVTQDKYLGNASAADWTYSGKVKTEDGNLIMTMPAKSVGTLFANNHYIWYGKISGKFKSSRGKGVVTAFILLSDVKDEIDYEWVGADLTAVQTNYYWQGVLDWHNSGNISVDGEDTFNDWHTYEIDWTPEKVDWVVDGSVQRTLKKADTYNETSKQYEFPQTPARLQMSLWPAGQASNAQGTIDWAGGEIDWNSEDIKTVGYDYATVGEVSVKCYDPPSDAKKSGSKAYLYTNSAAMESDISITNNNTVLASLGATGLDMDLGADKSSSSTASGSNSIPTGKGGSGGMTSNTTTSSDSSSSGTSTTDGETSTTGFTQGTPTGNGAAGQNERVLRGSLFGVLVALVVLVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NT91</accession>
    <name>A0A0G4NT91_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S001g000251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NT91"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005194781" evidence="1">
        <location>
            <begin position="22"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL17291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="251" mass="27890" checksum="920FA3DB0B847C77" modified="2015-09-16" version="1">MFPKIFLSVIFLLGLLGSVLAVGELKITQDTSLGSDMQAYSSKCTFKTQPEDADFLKMVEAALKEMQDIPGSRNAKDGRPAAMIGLSINNEVYFASSVRGRRQFVYEEVSWKGGDGTVNPPLPDNFREVTDALQSCADDHQTRPQHGNQASCGEIMSTLLWMVDNKNKSPRDYKPKIAAYNAKGYLPPCSSDPNAVKWGCAQWTQKMGLQVVQKIDDLPDDYTKPEKTEAVQLAKCLEVEVEEDETNQIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NTH5</accession>
    <name>A0A0G4NTH5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S001g000306</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NTH5"/>
    <dbReference type="STRING" id="1429867.A0A0G4NTH5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL17346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="207" mass="23133" checksum="A60C3772677216CB" modified="2015-09-16" version="1">MIGSVFFIFNRLVEIVFLIPIIGMLAYFVNGYLKANELTPPYILVLFIVSVIAIFWALDTLIRFSTTKRSAIFVAFVDLLFFGAFIASVYQLRFIANADCASWNGGSVWISLGPFGSYGQRTDNPLALNVNKTCAMLKASFAIGIMETAFFFWTALLALFLHHSHSPTVVKETTTVRRRSHSSRRGHGSGSHSRHRSSSRRPAPYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NTK5</accession>
    <name>A0A0G4NTK5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="14">ATP-PFK</shortName>
            <shortName evidence="14">Phosphofructokinase</shortName>
            <ecNumber evidence="14">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PCAMFM013_S001g000343</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14 15">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="14">Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 14 15">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="14"/>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NTK5"/>
    <dbReference type="STRING" id="1429867.A0A0G4NTK5"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005945">
        <property type="term" value="C:6-phosphofructokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070095">
        <property type="term" value="F:fructose-6-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000007">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000008">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03184">
        <property type="entry name" value="Phosphofructokinase_I_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009161">
        <property type="entry name" value="6-Pfructokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02478">
        <property type="entry name" value="6PF1K_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697:SF4">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000533">
        <property type="entry name" value="ATP_PFK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="10 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 14 15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 14 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="16">
        <location>
            <begin position="15"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="16">
        <location>
            <begin position="404"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal catalytic PFK domain 1" evidence="14">
        <location>
            <begin position="1"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interdomain linker" evidence="14">
        <location>
            <begin position="390"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal regulatory PFK domain 2" evidence="14">
        <location>
            <begin position="404"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="86"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="116"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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</entry>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NX06"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF18">
        <property type="entry name" value="NICOTINIC ACID TRANSPORTER TNA1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="46"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL18586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="497" mass="55723" checksum="24DAFE868B6A05F9" modified="2015-09-16" version="1">MAVMKLQTNHDDLESTHKVDLEVPLRDQNQVDDETKKIVHKVDKRLLPVLTFLYLICFLDRGNIGNANVAGMSDELNLTGTQYNIALTVFFFPYSVFEVPSNMVLKVVRPSIWISFLLICWGTVMTLQGIVQNYHHLIVTRTLLGLFESGFFPAATYLLTCWHRFEIQTRMSIFYTAASLSGAFSGLLAFALQKMDGIGGLSGWRWIFVLEGIVTVLTGLGCYWALPDSPQTASFLSCNERDIITQRLEQDTGTSSGRVGTNENFEWVYLTSALSEWKIYLAVVIFWSNTICVYGFTYSAPTIIHELGYTASEAQLLTVPIYFLCVCSTILFSRLSDKSQSRWLWIVVPYFIALVGLIGLLSIPHPRLPGLTYAFLFCIPAGVYPPLIGAVSWIGNNLAPSWKRVIGMALFMSIGNLGGAVGSNIFLTSQKPHYWLGYGMCMFIVVAAIISTLILRYAYASANAERDELDPSEIEGRYSDEELLKLGDRSPYFRYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NX55</accession>
    <name>A0A0G4NX55_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Serine/threonine-protein kinase TOR</fullName>
            <ecNumber evidence="16">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PCAMFM013_S002g000389</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Vacuole membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="16"/>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4NX55"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905356">
        <property type="term" value="P:regulation of snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05169">
        <property type="entry name" value="PIKKc_TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000020">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.150:FF:000001">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000371">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000582">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000006">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.150">
        <property type="entry name" value="FKBP12-rapamycin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009076">
        <property type="entry name" value="FRB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036738">
        <property type="entry name" value="FRB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024585">
        <property type="entry name" value="mTOR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026683">
        <property type="entry name" value="TOR_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF9">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08771">
        <property type="entry name" value="FRB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11865">
        <property type="entry name" value="mTOR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01346">
        <property type="entry name" value="DUF3385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01345">
        <property type="entry name" value="Rapamycin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47212">
        <property type="entry name" value="FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 16" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="FAT" evidence="18">
        <location>
            <begin position="1241"/>
            <end position="1816"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="17">
        <location>
            <begin position="1990"/>
            <end position="2310"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="19">
        <location>
            <begin position="2353"/>
            <end position="2385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU364109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CRL18519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="2385" mass="269973" checksum="DC96DE4BBEF56D6D" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NX75</accession>
    <name>A0A0G4NX75_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldehyde/histidinol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S002g000515</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NX75"/>
    <dbReference type="STRING" id="1429867.A0A0G4NX75"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006598">
        <property type="term" value="P:polyamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000001">
        <property type="entry name" value="Aldehyde dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720">
        <property type="entry name" value="2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720:SF3">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE ALDH (AFU_ORTHOLOGUE AFUA_8G02310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="30"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL18645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="502" mass="54382" checksum="41166F8E8DFD2926" modified="2015-09-16" version="1">MDLFIDIVTPNGHSYKQPTGLFINNEIVPATGGQTITSLDPATDKPIATVQAASAEDVDRAVKAAKAALVHPSWKLLPATERGQLMARLADLMEENRELFASIEAWDNGKPYHVALDEDLTEAISTIRYYSGWADKTFGQTINTTPQKFAYTIRQPIGVVGQIIPWNYPLSMATWKLGPALACGNTVVLKPAEQTPLSALILGTLIKKAGFPPGVVNIVNGYGREAGAALASHPLIDKVAFTGSTITAREIMKMAAGTLKNITLETGGKSPLLVFPDADMDQAVKWSHGGIMSNKGEICTATSRIFVHRDIIEAFTASYKTAVEAVKIGDQWDESVFHGPQVTRAQYDRILSYFEIAKSEGATILTGGAAHTPTDEKNKNGYFIQPTVIVNATDSMRIAREEVFGPVVVIFPFDDEEEAIRRANDTTYGLGASVFTRDLERAHRVAAEIESGMVWINSSQDCDPRIPFGGVKQSGIGRELGEAGLEAYSQTKAVHVNMGTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXY3</accession>
    <name>A0A0G4NXY3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S002g000818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NXY3"/>
    <dbReference type="STRING" id="1429867.A0A0G4NXY3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF156">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL18948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="495" mass="55154" checksum="2641BF5C3729498C" modified="2015-09-16" version="1">MSLLIWGLLIAFGAVIWIIHTYYFSPLSHIPNASILAPISRLLWEFPTEYRGRLTLELPKLHKRLGPLVRIGPNEVSFYSLDIYKRVHAAGSKFVKDPRVYSQFVQDGHPALFSITDPKEHAQRRRHMGVLFNRSKVPILAQMMVEEISRFNTLLDSRSQGSLDLIPTCRALEADIVSRFAFGSSIGAIESLMGGEELQVIKENDLKSSKMSLHTNFPSIMRMYGMISEVTSRVTGWGGSSKSSKDFEEWASEQLKLAADSEKAPEVSFLKVMAGERISPESALSESKEMLGPGTDTTSATLAHILWALSLNQSLQDDLVSDLSSANWTTDMTELESIPRLAACVKEGIRWTGAASAMLPRIVPTGGSLLDGKQIPGGTMISSSPIWYLHDETAFHEPHCYRPNRWLERDGDDSVALLSDYYIPFSKGPSTCIGNHFAYLELYLSVSQILKNYRIQQLEKSTINVNIEATLPPRLEWVAAVPIGKLQVAVSKRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NY48</accession>
    <name>A0A0G4NY48_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">PCAMFM013_S002g000878</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377:SF0">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <end position="221"/>
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            <end position="100"/>
        </location>
    </feature>
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        <location>
            <begin position="60"/>
            <end position="72"/>
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        <location>
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            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL19008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="242" mass="26813" checksum="C84F1326982954E1" modified="2015-09-16" version="1">MSLRPTLLTKWISRPSEILKTPSLSSYLRPATRPSFARHSTIFTQGTQAARRNLTTARFSTRTRPAPSSFQFKQRRFNSGSAGDGAKGSGSGSGSGAGASEKASLSQRLKKLSREYGWAALGVYLGLSALDFPFCFAAVRLLGVERIGYYEHVVIGFVKDKLKTVWPQTQSPETEDGQGQLAQAEERNQEEASIWTQLVFAYAIHKSFIFIRVPLTAAVTPKVVKILRRWGWDIGKRKPKST</sequence>
</entry>
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        <submittedName>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="105"/>
        </location>
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            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="208"/>
        </location>
    </feature>
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            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
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            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="341"/>
            <end position="360"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL19028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="360" mass="40283" checksum="9A73EF36EE863347" modified="2015-09-16" version="1">MVTPTHPPANAFVKVARRIYNPIGFAKGYNFVLYVIFAGAIVGFCLARLQFLALNDIFCNMQSTTGSAAPGECYWYSMPRYRIGIILHLASILPAGLLVVFQFIPAIRHKYLIYHRVAGYLIILLVFISIAGALMITDHSFGGHLATQTAVGALAIASTFGIINAYYNIKRLQIDQHRAWMLRVWFWMASIITLRIIMALSAVIISMYPSGWYQIMPCVELLYIANSTHMPLETVYSTYPVCSPGNSNMTVDSQVIVKANFNGNPEQIDAALDIGFPMAIWLALVMHAVGIELYLRLTPKEAERLRNVSYKRQLAAGMKNPGSAGLVPEKLGDMDLWEPEPELRHREDSSETVRMEDETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYH2</accession>
    <name>A0A0G4NYH2_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UV excision repair protein RAD23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S002g000993</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RAD23 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CRL19123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4NYH2"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rad23"/>
    </dbReference>
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        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015360">
        <property type="entry name" value="XPC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036353">
        <property type="entry name" value="XPC-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00601">
        <property type="entry name" value="rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621:SF0">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="145"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="334"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="80"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="192"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="192"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL19123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="381" mass="40197" checksum="5C055043D1A0C294" modified="2015-09-16" version="1">MKLTFKDLKQEKFVIDVEPSETVREVKVKIAQEKGEYEAERMKVIYSGKILQDDKTVESYNIQEKDFLVCLPSKQPKAAASTASQVPSTPAARAPVSTPAPPPAPHAAAAPPPSVAPATPSPAGAAPAPSSGPAFGDPSALTMGSAAEGAVVQMEAMGFARTDIDRAMRAAFYNPDRAIEYLLTGIPDNIQEQQQQQQRQASEPAPTGAAPAAPAAPSGGDEPHLNLFEAAAQAGGEGGGRSRGAAGAGAGAAGGEALGSLEFLRSNPHFQQLRQLVQQQPHMLEPILQQVAAGNPQIASIIGQNSDQFLQLLGEELEDEEGALPPGAQAISVTEEERDAIERLCRLGFPRDSVIQAYFACDKNEELAANFLFDQPDEDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYI3</accession>
    <name>A0A0G4NYI3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Peptidase M3A/M3B, thimet/oligopeptidase F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S002g001017</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL19147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NYI3"/>
    <dbReference type="STRING" id="1429867.A0A0G4NYI3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06455">
        <property type="entry name" value="M3A_TOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.40:FF:000001">
        <property type="entry name" value="Thimet oligopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000006">
        <property type="entry name" value="Thimet oligopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.40">
        <property type="entry name" value="Endopeptidase. Chain P, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024080">
        <property type="entry name" value="Neurolysin/TOP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF84">
        <property type="entry name" value="SACCHAROLYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="10">
        <location>
            <begin position="221"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL19147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="714" mass="81136" checksum="EAA2819D95A2CD03" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZA7</accession>
    <name>A0A0G4NZA7_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Alpha-amylase</fullName>
            <ecNumber evidence="4 16">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PCAMFM013_S003g000184</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4 16"/>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZA7"/>
    <dbReference type="SMR" id="A0A0G4NZA7"/>
    <dbReference type="STRING" id="1429867.A0A0G4NZA7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11319">
        <property type="entry name" value="AmyAc_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000120">
        <property type="entry name" value="Alpha-amylase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013777">
        <property type="entry name" value="A-amylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006046">
        <property type="entry name" value="Alpha_amylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF212">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001024">
        <property type="entry name" value="Alph-amyl_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00110">
        <property type="entry name" value="ALPHAAMYLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 16" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 16 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005194901" description="Alpha-amylase" evidence="17">
        <location>
            <begin position="21"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="18">
        <location>
            <begin position="33"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="11">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CRL19393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="462" mass="50029" checksum="6DF1E8D696C2BDE2" modified="2015-09-16" version="1">MKLSHTLTAFLLPLICNVSAADVKAWKSRNIYFALTDRIARGSDDTGGDACGNLGNYCGGTFQGLESKLDYIKGMGFDAIWITPVIANAPGGYHGYWAQDLYSINENYGTADDLKSLVDAAHEKGIYVMADVVANHMGGPISDNKPEPLNQESAYHSACTIDYSSQDSVENCRIADDLPDVNTQSTEIRELFQTWVKWLVTEYGFDGLRIDTVKHVEKDFWSAFSSAAGVYTIGEVWDGDPTYLAGYANDMDGLLNYAVYYPVNNFYQQKGSSQDIVDMHDKIDSAFPDPSALGTFIDNHDNARWLSVKNDKSLLANALAYVILARGIPIVYYGTEQGYAGGNDPANREDLWRSNFSTDADLYKTISLLSAARTAAGGLADNDHVHLYIADTAYAWSRAGGDLIVLTSNSGSGSTAEHCFDSKKPGGTWKSTLGEGTVTADDAGKVCISISNGQPAVLVAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZB8</accession>
    <name>A0A0G4NZB8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S003g000194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZB8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36986">
        <property type="entry name" value="UPF0643 PROTEIN PB2B2.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36986:SF1">
        <property type="entry name" value="UPF0643 PROTEIN PB2B2.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL19403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="261" mass="29906" checksum="A30F903E0C10F813" modified="2015-09-16" version="1">MTFTIDNPVLSNPVPSNALPATKSLPDKGKDQKVPNLTRLVHHSHVTTEFDPLRFEAAASLQLKLQLEKQYPDSETDTRLIASPYNNVPHLLDISALERQDRLFALALAYLKPIRDDYATAEYTESFNWTEVYDLLRTFSQAENHAWKSQSYYVVIFRSILLPDIDSDRLYDLDAHSHQEAIASGGLLKYWFGAKNDKHRNLATCIWRNRNDARLGGRGPWHAQARAAATVMYEEIKFTTLRLDIEDGVQSWNLSDWKEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZC5</accession>
    <name>A0A0G4NZC5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S003g000150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZC5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL19359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="100" mass="10970" checksum="DCA21347E5F3CC13" modified="2015-09-16" version="1">MIPAFVPVPSGGNYKLCTQGCWPAALLCSSPTVSPPNASWWIEIRVYLTSMGCAASNQGGKRLRQWHNLPLKIAFEVKLPEANQPFNREVPPNVLSGHII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P141</accession>
    <name>A0A0G4P141_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S003g000827</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL20035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P141"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF71">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00030237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL20035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="274" mass="31163" checksum="FADE3C4DD623EA47" modified="2015-09-16" version="1">MNGPRHFVDDEGHYIKPHTILDTGDAAVVVHREDVAIKMAIVYKNDTLEKVEENRSKIRREQEVWRRIQPKFDSPVEGIVHCLALRGDTIEMRYMSGGTLSKWLKSRARPSIDLQRQWFRQLTIGLHNLHQRRIIHSDILTRNILLDGSLNVAICDLGASSIMPIDTIMEDTVDEYNCSIWTDICQLGLVFYEIVTGRETGISLYDNSGGDNSVARFPSRHILPPVGTRIWARDIIETCWREGGYGAAGAAGILAKLDKFQGWCRRYDVSSIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P154</accession>
    <name>A0A0G4P154_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S003g000805</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL20013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P154"/>
    <dbReference type="STRING" id="1429867.A0A0G4P154"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
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    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="4"/>
            <end position="33"/>
        </location>
    </feature>
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        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="70"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL20013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="402" mass="45782" checksum="F1602EFF61A8B64A" modified="2015-09-16" version="1">MPQFQCQVPGCTSTYRRKEHLRRHEAQHRGSHLRICSICDRVFSRSDSLRRHIRRDHEDPGRSLVRATQACIRCRTTKARCQGGSPCTECSLKGHLCLFDDPVHLEPAQTHPEEALREYGSGDDRINTSDRINTPIGRIAQVDHYVHLYFTDFHQHWPILHRHTFSVADEPQLLLQAVIMIGLWVSGSPAAQEGARNLHSKLKLAISAQQDNWARSPVEGEQDNEGLDSPSSRWPIATYQGILLCVIFSLLSTPIGLGLNLGLVLSVSDRQIFSALVATCLRNNIFYYPNMLTRYRNVESLTCIWVGVEEIKRLGLALYKVSRLCGRGSLGEPDETDSRVLRLSDLQFPMPDEKNLWDARSNPELARRLLIYSRRDHSDDPGVTNWVSQSGILLETDENWWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P1H4</accession>
    <name>A0A0G4P1H4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S004g000068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4P1H4"/>
    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL20128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="644" mass="70974" checksum="8B219CCA5FC97687" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P1M7</accession>
    <name>A0A0G4P1M7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily, general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S004g000160</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P1M7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF224">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="236"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL20220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="425" mass="45415" checksum="400CFCF83721439B" modified="2015-09-16" version="1">MSTDGTLTETHDPSLINSTNSPDSENGTHKEVIPEWKKSKAPDGGLAAWSVVLGSWCVLFCTFGWINSVGVFQNYYESTLLSQYSASTIAWIPSLQIFFMYAMGPVSGHLYDNYGPRYSVLFGSLLHVFGLMMCSISTKYYQILLSQGVCSAIGVSIIFQPTYGLMSTGSSVGGVIFPIMIQQLIPEVGFAWAMRAGAFVILFLLTTANLTIRSRLPPSPRPVSRAALTQPLKETKMLLVIAGFTLLTFGVYIPIDYLVVEGLSSGISTNLSQYLLAILNAGSFFGRLGAGMIADQIGTYNVFAVVCYLAGIFILAIWIPATGAAGTIVFAVLFGCCSGAYVSLAAALVVKISPLPQIGYRVGLIFLFASIGGLTTNPIDGAILSHDNGTYLGMKVFAGVLLLAGTTCVFGTRLLYTGLKLVAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2M3</accession>
    <name>A0A0G4P2M3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc finger, C2H2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S004g000517</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P2M3"/>
    <dbReference type="STRING" id="1429867.A0A0G4P2M3"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
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        <location>
            <begin position="18"/>
            <end position="52"/>
        </location>
    </feature>
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        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
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            <begin position="97"/>
            <end position="176"/>
        </location>
    </feature>
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        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
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        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL20576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="258" mass="28552" checksum="E73122BC02358B63" modified="2015-09-16" version="1">MVYTSDLEEYLRLRQIFQPSSEKRNSHAETSAMQPPPPFAGQSSLPSAGWPLYDPSMSHTSAFLGPSWTTPTQPPTSAVGHRPVPSTNWSLYDPSMGHVSRSPHPGRTMHTAIGHPTADNFYQGNMQTSPTMQYRDTEVGTEDHLSPGQTTAHTWSSTPSPSTQESSPPNQHSSGAATVESNFVHGEPQQQDESDGSFKCGWGGCTRRETFSSHASLMRHIKVQHVAHRSVKCPECGQAFGRVDNMKEHRGRRHRMFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
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    <name>A0A0G4P4G5_PENC3</name>
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        <submittedName>
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        </submittedName>
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    </gene>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4P4G5"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL21177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="188" mass="21440" checksum="C1B1B09D5231A311" modified="2015-09-16" version="1">MVDCHANAEEEILIERVQVTDLENAAYLPKGRCIKGMLAGNDNWRSPEAHFKGELNKPTDLFSFGVVCIYAMLGRVIFGPDEDFRVHESKGALPAFIRLQRQVSYFGDQAGIDGLLKHISDDEVGSQVLRMFWEDRDEDRIPYIPFSEWVDVCDAAFNDLIRGLTCLDPTRRITAHQALQHEWLTDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 4</fullName>
        </recommendedName>
        <alternativeName>
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        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED4</name>
        <name evidence="11" type="ORF">PCAMFM013_S005g000573</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 4 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CRL21409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4P526"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019258">
        <property type="entry name" value="Mediator_Med4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13208">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13208:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10018">
        <property type="entry name" value="Med4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="247"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="53"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="247"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00031257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL21409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="313" mass="33486" checksum="699196DEEBA3CA6F" modified="2015-09-16" version="1">MNALVQSALTDVESKLNALLTSLTTSPTAAGAPAAAVALLDADDALTAAIETLRQHQENHAKILRLRNEAQKLEDRVKGIVGDIEGFEKEIRTACGDNGDSDSDFDSDSDDDLGGKKSLLRGIKEIDYRLLLDFARRISKYNHEAAADAATGVVKRQEQGKTLADKDVTMTGTNGEQPTEEGAEPVASVTKNATQWLDESANVTRQVYMLPYPMEERIRMGLMGQIQLSASDDPEKEVERLLREAEGLGAAEPPAPVEPAESTKQAGEAAKAAVQAGSSAAGMPRAHVPAPAPKPKPKAMLDLDLYDPDEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5B9</accession>
    <name>A0A0G4P5B9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S006g000042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P5B9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL21502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="127" mass="14094" checksum="F4892259A54DCD44" modified="2015-09-16" version="1">MPKGHSYNSSIECFTFKFERILSIKLSLSPGTKGIGRQVPLGSTILKNLNQPLRPSSPVIGPFHKPYIVHVPAIPFPLVISNALLDGEIAFAKTVTNKYREQMKGKIDDPRNIQTPVNRPNYPMPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5L1</accession>
    <name>A0A0G4P5L1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S006g000104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P5L1"/>
    <dbReference type="STRING" id="1429867.A0A0G4P5L1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431:SF7">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="123"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL21564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="331" mass="36645" checksum="D30E5F240E5A9A7B" modified="2015-09-16" version="1">MASKALAIIAGVGPGTGASIARKFAKSYSVVVLARNPDNYNPVVQEINSSGGQAIGISTDVSDSKSVNAAFDKIQAEYPSSKARWVVCGNHQKKNEDSIFYAPVISNTLVNVIFTLIAHASREEEEILYVMQPLGIEYSEPEIGPKGWVCQLNQALYGLRDSAKLWNDDLNAKLEAIGFVPLDDDPCVYIKGTGSTAWFLIEVEQIFQDVRSQFEVKDMGEPSGFLGSGIQRNYQNRTVTISQQAYTEEILRLAEIQNCKATPIPLSSSWVWDDDNEDPETLLYGKDQTKYCALVDRLNWLALETRPDIKFADMKLQHRGASPTESEAYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P680</accession>
    <name>A0A0G4P680_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Centromere protein Cenp-I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S006g000319</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-I/CTF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P680"/>
    <dbReference type="STRING" id="1429867.A0A0G4P680"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000939">
        <property type="term" value="C:inner kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22647">
        <property type="entry name" value="CTF3_NTD_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012485">
        <property type="entry name" value="CENP-I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48208">
        <property type="entry name" value="CENTROMERE PROTEIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48208:SF2">
        <property type="entry name" value="CENTROMERE PROTEIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07778">
        <property type="entry name" value="CENP-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL21779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="723" mass="81545" checksum="468C7526C6CF167F" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6C3</accession>
    <name>A0A0G4P6C3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S006g000406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P6C3"/>
    <dbReference type="STRING" id="1429867.A0A0G4P6C3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL21866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="71" mass="8311" checksum="EEC4CEC003BF6057" modified="2015-09-16" version="1">MHHLALLNYRTPYDRLVYLKARFARSSAYEEEIHKKVYNTRDLIESFRAMNREVGVQTITSTTALKSAFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6T5</accession>
    <name>A0A0G4P6T5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mov34/MPN/PAD-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S007g000026</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67A family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P6T5"/>
    <dbReference type="STRING" id="1429867.A0A0G4P6T5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08062">
        <property type="entry name" value="MPN_RPN7_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000004">
        <property type="entry name" value="26S proteasome regulatory subunit rpn-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033858">
        <property type="entry name" value="MPN_RPN7_8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF7">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="5">
        <location>
            <begin position="16"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="304"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="337"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL22045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="352" mass="39267" checksum="3812B36AD9C8BDE8" modified="2015-09-16" version="1">MPATTADTLSLVNRSVTVAPLVLLSVADHYGRTAKGTRKRVVGVLLGENSGDNVRVSNSFAVPFEEDEKDPSVWFLDHNFVESMRDMFKKINAREKLVGWYHSGPKLRASDLEINELFKKYTPNPLLVIVDVQPKEVGVPTDAYFAVDEIKDDGTTTSRTFVHTPSIIEAEEAEEIGVEHLLRDIRDVAVGTLSTRITSQLQSLQGLHLRLRDIGQYLQKVLDKELPVNHAILGNLQDVFNLLPNLSTPPATQRTNGQEPQIENSELARAMSVKTNDQLMAIYISSLIRAITAFHDLIDNKIQNRQQQEESDTKRDQEANGTKGDKDAKKAGSPNGDQKEEQDSSDKNKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6Y3</accession>
    <name>A0A0G4P6Y3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent pyridine nucleotide-disulphide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S007g000042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P6Y3"/>
    <dbReference type="STRING" id="1429867.A0A0G4P6Y3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050982">
        <property type="entry name" value="Auxin_biosynth/cation_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539:SF68">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL22061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="635" mass="70715" checksum="A11B0DBCA950AE58" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7B5</accession>
    <name>A0A0G4P7B5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S007g000171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P7B5"/>
    <dbReference type="STRING" id="1429867.A0A0G4P7B5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL22190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="178" mass="19946" checksum="FED7D9F858FF5940" modified="2015-09-16" version="1">MNTSISPVSKPAVSLTGPTGAFMVELLIWNGSPFKDHWAYFVRSHADPDIGVKIHATGNVRSGFEFEIKRSENLQTTDDIPSTRVPLQWVDANYFDEKAMLNDGEYKVDNAPVCGFERSAYEIKAPGKSLNTISDGFKPGRKVIQRDCQTWIVESADQLRRDNILSNEVVAYLHAIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P829</accession>
    <name>A0A0G4P829_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S007g000428</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C56 family. HSP31-like subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="1"/>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P829"/>
    <dbReference type="STRING" id="1429867.A0A0G4P829"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03147">
        <property type="entry name" value="GATase1_Ydr533c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF11">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="6">
        <location>
            <begin position="29"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL22447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="238" mass="25646" checksum="474424B640BF47F8" modified="2015-09-16" version="1">MPARKALISITSASATLFDGKETTGLFIVEALHPYKALTAAGFEVDLASESGSYTADWLSQQPDFLNGEDLEIWNNLDSEFRKKLDNMPRASELDGSQYGLFFASAGHASLIDYPTASALQNIAEQVWANGGIVASVCHGPAIFTNLLDRTTGKPLIQGKKITGFTTEAENTMGIMAELRGFGSEMVEELAERLGAKYERSAGIWDDFHVVDGRLVTGQNPASSTSTAKAAIEVFDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P8J0</accession>
    <name>A0A0G4P8J0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S008g000013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P8J0"/>
    <dbReference type="STRING" id="1429867.A0A0G4P8J0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL22584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="122" mass="13749" checksum="669F658FBC483CFE" modified="2015-09-16" version="1">MQITSEFPLTVIRAGTTNSYDRFRNAKQAEKATLEVSVNAEDPAFKSMMLKELVAIQPEVDECHASEGDQRLLHQKKPKKQVDDEGLAQYIIDQQYRHADQRADARAKRKGRGIHALMNGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P917</accession>
    <name>A0A0G4P917_PENC3</name>
    <protein>
        <recommendedName>
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    </gene>
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13282">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13282:SF6">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08555">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL22800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="14651" checksum="18AFDE0BD76FC4CE" modified="2015-09-16" version="1">MAGDEYSVGGGKLKLKGSKVSGGRIEKKKKKSTKKKEGDATQPKAESTPGTEQSENGKDEGVRSEEDREKEWDAPGKTEAEKKAEEIRRKRLHERLQREGVKTHKERVEELNKYLSRLSEHHDMPKIGPG</sequence>
</entry>
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            <fullName evidence="8">Fungal transcriptional regulatory protein, N-terminal</fullName>
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
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                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="prtT"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF38">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
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        <location>
            <begin position="53"/>
            <end position="140"/>
        </location>
    </feature>
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            <end position="80"/>
        </location>
    </feature>
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        <location>
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            <end position="140"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL22871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="701" mass="78808" checksum="F255A0D3CB264F74" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P996</accession>
    <name>A0A0G4P996_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S008g000306</name>
    </gene>
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            <taxon>Pezizomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
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                <person name="Lacoste S."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
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        <location>
            <begin position="20"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL22877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="113" mass="12303" checksum="5924C5E3E8DBDFEA" modified="2015-09-16" version="1">MQLTTLFTVCVAALTSTTAAMPHLSGAYHGARLSVRIPTNATSPHNATTTGTRGKAPLSTGSSHMNRVNVNRCHELCSLQSQTCSIAVPDDDKFCWSIYLQCTEKCHPENFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P9P1</accession>
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        <submittedName>
            <fullName evidence="8">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Dupont J."/>
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                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF23">
        <property type="entry name" value="FLUCONAZOLE RESISTANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF11">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="504"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="639"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="543"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="656"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL23816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="734" mass="82169" checksum="314EE4F9305D425C" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PC89</accession>
    <name>A0A0G4PC89_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S010g000364</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PC89"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="SDR_fam"/>
    </dbReference>
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        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
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        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF18">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G12480)"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL23926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="301" mass="31855" checksum="3A2867ED58C96A00" modified="2015-09-16" version="1">MTSAVDSSAIFRVDGIVAVITGGGSGIGLTMSRALAANGARKVYILGRRLEVLEKAAEEYTSIVAVQADVTSKADLQAAVDRIKNEVGYVNLVVANSGNIGPAVRFSPSASISELRETLFTNFSPDEMNDALALNITAAFFTMTAFLELLDAGTRNALQGGFGKPPKEGTDVPSIQSQVIFTTSVSAFSRHWSSSPPYLTSKVAIMQVAKHASTQLARFGIRVNAIAPGVYPSELASALIGNRKPEEEAFEDQRFIPARRFGGDEEMAGAILYLASRAGSYSNGSILLTDGGRLSVMTGTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-11-27" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PD85</accession>
    <name>A0A0G4PD85_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF967 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S011g000284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PD85"/>
    <dbReference type="STRING" id="1429867.A0A0G4PD85"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.150:FF:000005">
        <property type="entry name" value="UPF0303 protein Ping_1243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="entry name" value="Haem-degrading domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010371">
        <property type="entry name" value="YBR137W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28255">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28255:SF1">
        <property type="entry name" value="UPF0303 PROTEIN YBR137W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="HbpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="GlcG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL24290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="22247" checksum="AD3BD72AC3CC8567" modified="2015-09-16" version="1">MALSAPSTDASPPYSSQHPKPQKLTNKQPKVLLAQETSADQLFPTFTADTAWQLGNALRDRILRLPEGQRKPALVSIALSGGAPLHVVFQSATESGTIPDNENWVRRKRNTVLRFGVSSWTMRQKTVSGLAAGASADDVEAAFVSKYAVPSATGGSVADEYAIHGGAYPIRVRGVDGIIGVVVVSGLKQEDDHQVVAETIQAFVAQQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDC7</accession>
    <name>A0A0G4PDC7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidine phosphatase superfamily, clade-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S011g000268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PDC7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF54">
        <property type="entry name" value="PHOSPHATASE SPAC5H10.03-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
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            <end position="274"/>
        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL24274.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="274" mass="30918" checksum="73C1DD5827BA0013" modified="2015-09-16" version="1">MTPIIHCVRHAQGLHNVCTANHVIQDPLLTDLGHEQCKTLRENFPRHANIDLVTASPLRRTLYTALESFAPVFESKPDLKIIALPDIQETSDVPCDTGSEPSVLKEEFKTGVDLDLVQEGWNNKLSGRYAPTNKALKERARAARRWLKARPEKEIVMVTHGGFLHYFTEDWEDSSQYQGTGWSNTEYRTFSFSEETHTDDLEGYPLDGDNASLEETIDSRQRRGKTGPMPSREEQKTLYKKGTQGWDDQGLQMSTADREAAKVTGGEEVNGVRI</sequence>
</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
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                <person name="Debuchy R."/>
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            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <source>
            <dbReference type="EMBL" id="CRL24325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="36" mass="4002" checksum="C7A2C04012B51296" modified="2015-09-16" version="1">MIHQRTNCKPKEDSEMPTDITLGIVGPETVVDFEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDE9</accession>
    <name>A0A0G4PDE9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cyclic peptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S011g000340</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
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    </dbReference>
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        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF399">
        <property type="entry name" value="ABC TRANSPORTER ATNG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="521"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="884"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="923"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="998"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1023"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1101"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="265"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="595"/>
            <end position="828"/>
        </location>
    </feature>
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        </location>
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        <location>
            <begin position="1208"/>
            <end position="1448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CRL24346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1455" mass="158427" checksum="7B744B19266996FE" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDJ3</accession>
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    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL24324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="100" mass="11254" checksum="FEB8BBD8F9FFDBCE" modified="2015-09-16" version="1">MRKAAGHRENARDNQEMLADLPEDIGILCSILSFYILIYSLADRMFIHGLKALSKENVPKELAQQLEARTFPHAIHEIYSSTPASDRGLRDLVVGITMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDS2</accession>
    <name>A0A0G4PDS2_PENC3</name>
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        <submittedName>
            <fullName evidence="11">Sugar/inositol transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S012g000089</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF45">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="369"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="17"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL24480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="520" mass="57464" checksum="26CBE75A2130402F" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDS6</accession>
    <name>A0A0G4PDS6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S012g000033</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PDS6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PDS6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF10">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ANK_REPEAT"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="276"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="3">
        <location>
            <begin position="552"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1037"/>
            <end position="1069"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL24424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1175" mass="132326" checksum="48DEB3C8E3B84B04" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PEB9</accession>
    <name>A0A0G4PEB9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DNA methylase, N-6 adenine-specific, conserved site</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S012g000221</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
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                <person name="Ceppi M."/>
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                <person name="Goarin A."/>
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                <person name="Lacoste S."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PEB9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PEB9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
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    <keyword evidence="5 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="690"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="101"/>
            <end position="133"/>
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    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="134"/>
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        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
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            <begin position="167"/>
            <end position="199"/>
        </location>
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            <begin position="201"/>
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    <feature type="repeat" description="ANK" evidence="7">
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    <feature type="repeat" description="ANK" evidence="7">
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            <begin position="269"/>
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    </feature>
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        <location>
            <begin position="732"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL24611.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="762" mass="84360" checksum="789F654F2D2B79A7" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PEH4</accession>
    <name>A0A0G4PEH4_PENC3</name>
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        <recommendedName>
            <fullName evidence="3">Myosin-1</fullName>
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        <alternativeName>
            <fullName evidence="17">Class I unconventional myosin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Type I myosin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">PCAMFM013_S012g000266</name>
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    <organism evidence="24 25">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Type-I myosin implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions as actin nucleation-promoting factor (NPF) for the Arp2/3 complex. Plays an important role in polarized growth, spore germination, hyphal morphogenesis, and septal wall formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 19">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
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        <property type="protein sequence ID" value="CRL24656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0001411">
        <property type="term" value="C:hyphal tip"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MYOSIN-3-RELATED"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51757">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 19" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="10 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 19" id="KW-0505">Motor protein</keyword>
    <keyword evidence="11 19" id="KW-0518">Myosin</keyword>
    <keyword evidence="8 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 18" id="KW-0728">SH3 domain</keyword>
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        <location>
            <begin position="50"/>
            <end position="729"/>
        </location>
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    <feature type="domain" description="TH1" evidence="23">
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            <begin position="787"/>
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        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="21">
        <location>
            <begin position="1093"/>
            <end position="1154"/>
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    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
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            <begin position="602"/>
            <end position="624"/>
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    </feature>
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        <location>
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    <feature type="region of interest" description="Disordered" evidence="20">
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            <begin position="1155"/>
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        <location>
            <begin position="1010"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="1022"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1056"/>
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    </feature>
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        <location>
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        </location>
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        <location>
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    </feature>
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        <location>
            <begin position="1177"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1218"/>
            <end position="1234"/>
        </location>
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        <location>
            <begin position="1235"/>
            <end position="1253"/>
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    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="143"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025425"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00029665"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00032645"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50002"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51456"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51757"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL24656.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1267" mass="138981" checksum="EACDA91D32D0A830" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PEP5</accession>
    <name>A0A0G4PEP5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S012g000336</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PEP5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000286">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000308">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="49"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL24726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="451" mass="48448" checksum="FD2141EB55B1D677" modified="2015-09-16" version="1">MSIGVQDSPHATIYESQPRQHENQSSSSSESSSQIDDEKWNHPRSNIAKTLATFWSFLIMGANDSAYGPLLPYLESYYNLSYTIVSLVFLSPLLGYATAAIVNERAHCAIGRRGVACVSSLCHLIAYILNCVHPPYPVLVVSFIFAGLGNGLADSAWNAWIGNLDNANQLLGLLHGSYGVGAVISPLIASLLVADAGLPWYYFYYIMIGGAAIEIFVCVACFWDSTGASFRLAKEQQPGDTSEKAGLRRVLSTMPFARVTWICSIFLLGYVGVEVALGGWVVTFMKKVRHAAPFASSMTSTGFWLGITLGRVILGFVTPLIGEKIAISIYISLEIAFCLILYLVPNFYAGAVAVSLQGFFLGPMFPAVVIVTTKLLPKHLHVSAIGFAAAFGGGGAAVLPFIVGVLAQAKGVEVLMPFIIALSGAMLLLWNFLPKVPRDSSASANHDREAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PEY6</accession>
    <name>A0A0G4PEY6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutathione-dependent formaldehyde-activating, GFA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S013g000104</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL24861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PEY6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PEY6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052355">
        <property type="entry name" value="CENP-V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620:SF1">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620">
        <property type="entry name" value="CENTROMERE PROTEIN V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="4">
        <location>
            <begin position="14"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL24861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="136" mass="15244" checksum="F4149F259380D3E3" modified="2015-09-16" version="1">MPFPPTPTGESSFHSGNCHCGAVRFTFTISPPLHEYPTNSCNCSICTKNGYLLVYPLSKDFTIEKGEDILKDYRFAERKVKHQFCGECGSSCFIHLPEEGFPPITPVNVRLLQDVDIEKLILNKVDGKSVGKEYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PFN6</accession>
    <name>A0A0G4PFN6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S014g000017</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PFN6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PFN6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000049">
        <property type="entry name" value="C6 finger domain protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF2">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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        </location>
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            <end position="138"/>
        </location>
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            <end position="425"/>
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            <end position="126"/>
        </location>
    </feature>
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            <end position="414"/>
        </location>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL25121.1"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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</entry>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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        </citation>
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        </source>
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            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="129"/>
        </location>
    </feature>
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            <end position="96"/>
        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL25729.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="129" mass="14348" checksum="DDC296099D5A5424" modified="2015-09-16" version="1">MTGAILYLRHLKIVDTPGFVPNGYRKTHYRKNVGYSDDDQCACGAQETVTHMLVDCPNLREPRRELRREVGDAFNSVSSLLGGSKQGEKGKPDTVTRARTVNAVLDFVETSQRFRSRAPPGQPNNGNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-11-27" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PHD8</accession>
    <name>A0A0G4PHD8_PENC3</name>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004923">
        <property type="entry name" value="FTR1/Fip1/EfeU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632">
        <property type="entry name" value="IRON TRANSPORTER FTH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632:SF2">
        <property type="entry name" value="PLASMA MEMBRANE IRON PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03239">
        <property type="entry name" value="FTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0410">Iron transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL25744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="379" mass="41364" checksum="2A6A794BD96497EF" modified="2015-09-16" version="1">MGSNKVFAVTVFFICFRECLETTVVVSVLLAFLKQSLYESDRPTYKRLVKQVWLGCGLGLFICLAVGAGMIGGFYGLGTDTFSSTEDIWEGVLGIIASIIITIMGAALLRVSKLQDKWRVKLAKALQTEHDPNETRKGRVKRWLEKYAMFILPFITVLREGLEAVVYVGGVGLGLPATSFPLAVVCGLLAGVAVGYVIYRGGRQTSMQIFLIISTCFLYLVAAGLFSRGVWYLENNAWNHIIGGDASETGSGAGSYDIRQSVWHVNCCNPEIGGGGGWGIFNALLGWTNSADYGSVIAYNLYWICVMVGYGLMFYREKRGAIPVIDPAMNKVARAKARARAFILRRPYEDPTAPVETTAPVNMTVPVSEKRAETGISAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PIG0</accession>
    <name>A0A0G4PIG0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Yeast eukaryotic release factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S017g000102</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793150">
        <property type="protein sequence ID" value="CRL26119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PIG0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PIG0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04165">
        <property type="entry name" value="GTPBP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03694">
        <property type="entry name" value="GTPBP_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03708">
        <property type="entry name" value="GTPBP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000014">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000091">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035531">
        <property type="entry name" value="GTPBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF9">
        <property type="entry name" value="GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="5">
        <location>
            <begin position="187"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="606"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="620"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL26119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="629" mass="68636" checksum="92BFDBC2D1DB1B49" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PIN9</accession>
    <name>A0A0G4PIN9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S017g000273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793150">
        <property type="protein sequence ID" value="CRL26290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PIN9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF26">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY OXIDOREDUCTASE (JCVI)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL26290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="256" mass="27129" checksum="5D9B80B3F82E8677" modified="2015-09-16" version="1">MTSTANTVYLVTGANRGLGLGLTKRLLERPATTVVASVRSHDTATSLRSDVEGVEFGENSVLHIIELDFSTAIPPEKIAQTFAETVSTVTHIDVLICNAGFAAPLTPALVTLAEDLRNSFEVNTIAPLLVFQAFWPLLQRSASTPKVVVISSSVGSIADQEPVPGGAYGPSKAASNWLTKALHVENKADGLVAFALHPGWVQTRAGDFAAKEWGYPDAPPVTVEDSVKGMLGVIDNATRENVSGKFMSLTGDILSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PIT7</accession>
    <name>A0A0G4PIT7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S017g000242</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793150">
        <property type="protein sequence ID" value="CRL26259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PIT7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PIT7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL26259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="386" mass="44106" checksum="220699EFBCB83DEE" modified="2015-09-16" version="1">MLDLVRSNPITTMPEIQQLLYNIATINSPSTHCNSIESYLELCPNARTDSMAEGTPFGLPDQTTTQEIIHIISLAANIQRLACMCLYTMQQNFISAVEKSLGSPAAQRAAEPIVWIEEYRVYWVLWHFQHYSSLWKTAKSRWNWSKESCKNLGDTYMTWNNISTGLREQIWTVASVLGDLGLHPLYGHSHKKGAEETNLEEEEGHEEESSIAAWEFPAETPIPIPFFSSLEPPPSLHSNQGDFPIWSPAPLPDDDSQTEKFWGRTSRSRLEMSNCAPMIHSYTVIIKSRPAFQQAWRDIRQVQPFRRVGAMVWTRWRMYSVGLYSSCPRGMEISTPDGDYVRETDFRLSTYDVISRWLALVGKPPPDVGENYDNRPSTLAKIINPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJR4</accession>
    <name>A0A0G4PJR4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BAR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S019g000084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJR4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJR4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07600">
        <property type="entry name" value="BAR_Gvp36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018859">
        <property type="entry name" value="BAR_dom-cont"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10455">
        <property type="entry name" value="BAR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="2">
        <location>
            <begin position="10"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="191"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL26667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="305" mass="33781" checksum="840914343E4A2B27" modified="2015-09-16" version="1">MDRMQAFGKNFSANFTPFAQRTQQMIKEQLGQADDKTQLPDEYIELEKRVDALKLVHQKLLQVTSQYSNEAYDYPPNIRESFNDLGRTINEKVQLLSQAASPAEAQAALTTPPSAKPQPKTFNHAIARASLAGSQTLAQSTESEDPLATALEKYALAEEQVGEARLAQDAQIQSRFLAGWNTTLNTNLMFAAKARKNVENARLMLDSIKASKKAGAHGDLDNLSEDARAEIEQAEDEFVGQTEEAVSVMKNVLDTPEPLRNLADLIAAQLEFHKKSYEILSELAPTVDALQVEQEASYRKIREGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PK31</accession>
    <name>A0A0G4PK31_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sidoreflexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S019g000202</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sideroflexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PK31"/>
    <dbReference type="STRING" id="1429867.A0A0G4PK31"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:monoatomic ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990542">
        <property type="term" value="P:mitochondrial transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004686">
        <property type="entry name" value="Mtc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00798">
        <property type="entry name" value="mtc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153">
        <property type="entry name" value="SIDEROFLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153:SF6">
        <property type="entry name" value="SIDEROFLEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03820">
        <property type="entry name" value="SFXNs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL26785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="339" mass="36535" checksum="8F2B17D53184F5FE" modified="2015-09-16" version="1">MSASLPGSRDLPPSQYDLKTYWGRVRHAADISDPRTLFVSPAGLESAKSLIASYKQNRIPGMTPELWSAKKVVDATLHPDTGTPVFLPFRMSCYVLTNLVVTAGMLTPGLQTTGTLLWQIGNQSLNVAVNNANANKSTPLSLSQIGKSYLMAVSASCSVAVGLNALVPRLKSITPNTRLILSRLVPFAAVASASALNVFLMRGEEIRQGIDIYPVLSEAERAKRELSEDAEPVQSIGKSKKAATIAVGETAISRVLNATPIMVLPPLILVRLEKTNWLRARPRMVMPINLALILGTSIFALPLALAAFPSRQAISVDSLEEEFRGRGGDLGMVEFNRGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKL4</accession>
    <name>A0A0G4PKL4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glucose-fructose oxidoreductase, bacterial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S020g000101</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793153">
        <property type="protein sequence ID" value="CRL26942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKL4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PKL4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF3">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G10240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="6"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="4">
        <location>
            <begin position="139"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL26942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="353" mass="38904" checksum="28EF82CDE56EC947" modified="2015-09-16" version="1">MSAPKLRVGIAGLGRMGQRHALNYHVFTPRAEVVAASSPDLNEHKWAAENLTGARIYKDYYEMLEKENLDAVVVAGITAVHADHTIAAIKKGLHVMCEKPLSLDIKIAQSVLDAYNTSLKTHPNQKVMCGFSRRFDASYREAYERMVSGQHGRPVVFRSQTADMLDTTGTFVNYAKTSGGIFLDCSIHDIDLMLWFLGENTNIKSLQAVGVVAVHTALDSSKDRDNAVATVEFDGGKIATLFCSRMMAAGQEDTTEIICEKGSLRVNMQGRKNHLEIHDGQGARRDLPKHYYERFREAFLTEANEFTASCLDNTTPPVSLSSSVKAVVIGSALQKSLVTGEKIVFDFGKEARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKS7</accession>
    <name>A0A0G4PKS7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S020g000108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793153">
        <property type="protein sequence ID" value="CRL26949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKS7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL26949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="131" mass="14188" checksum="0F4BAA22966F7218" modified="2015-09-16" version="1">MSPPGMFSRPDGTNIPEIKSTQSVHWVTVDFTKFGGRTKPTGGDRMMRLMAEQCRSGVATITSTPLHHTQPCCLSLPVVGDPELVRVHILWRAAEIADSHWEEITAGKLVVDTQRILGDGPGGSRNIVNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PM69</accession>
    <name>A0A0G4PM69_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S021g000193</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
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                <person name="Bensimon A."/>
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            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
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        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
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    </evidence>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    <keyword evidence="2" id="KW-0813">Transport</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL27732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="533" mass="59066" checksum="E4499C99081D643E" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMT3</accession>
    <name>A0A0G4PMT3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S022g000128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793155">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PMT3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PMT3"/>
    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL27448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="353" mass="41316" checksum="7DF19D6B4A2B8B33" modified="2015-09-16" version="1">MSLFLNLPFELRILIIEHVLYTPLSPPLTPLESDGIEYHDLTYNAWVNRGRNAYYNHQSKPSPSNCLPLLLTNHQISIETQAILGRRKVEYILDISVKDDLRILLTWLSVPCLTTHISTLYVNVRLFGHIIEKRTIRSQLGDGGRLGFHWYFYAALERFFRYGPVGEKKRKEEDETSEYPRNTEEFQDRGMLIDTLVLDFQSAELELSFPPEDVTYKQWSGRHWGRDRGDQSETSETLSSYKTRPEWLCEYLKAWISGLLYMSYHTSKFGQPLYEHIGTIRMLVDGQLYHEFDLAAWLARLRFTDPTSMMGHLSTDDRQSGFWNWKKETLLRRKAQGFPVIWPSDDEFGGSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNZ6</accession>
    <name>A0A0G4PNZ6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S025g000167</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793158">
        <property type="protein sequence ID" value="CRL28109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PNZ6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000001">
        <property type="entry name" value="50S ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL28109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="298" mass="32536" checksum="823F99E563AA11C4" modified="2015-09-16" version="1">MSSSGSVLPTAARGILSSCRNPLRNTSIAPSLSTFQQVRGLKNKPKKGKEQPTKSRKGPQEFRQINLKDMPQYSLCDAMRYIRAIEVGREPTVQKYELHIRLRTKRDGPVIRNMLRFPHAVQTESRICVICPPGSKAAKEALAAGAVLVGEQEVFDAVKAGTIEFDRCLAHPDSLPALNKAALGRILGPRGLMPSAKTGTVVEDVAARVEMLRGGTVYRERDAVIRLPVGQLGFSPEQLRDNMRVTLDQIKKDASALTDRVNKEVYEVVLSSTNGPGFSLNGEFRSDASPPTSALKGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPS1</accession>
    <name>A0A0G4PPS1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase, catalytic core</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S027g000106</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793160">
        <property type="protein sequence ID" value="CRL28417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PPS1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PPS1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000008">
        <property type="entry name" value="Beta-N-acetylglucosaminidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000013">
        <property type="entry name" value="Glycoside hydrolase family 3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050226">
        <property type="entry name" value="NagZ_Beta-hexosaminidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480">
        <property type="entry name" value="BETA-HEXOSAMINIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480:SF8">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 3 N-terminal" evidence="6">
        <location>
            <begin position="15"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL28417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="930" mass="101487" checksum="6B5711F52C70247B" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPV5</accession>
    <name>A0A0G4PPV5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S026g000056</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="706" mass="79087" checksum="60CEFEF51AC10AC2" modified="2015-09-16" version="1"> </sequence>
</entry>
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    <accession>A0A0G4PQB8</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
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                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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    <accession>A0A0G4PQQ0</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Dupont J."/>
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                <person name="Abraham A.L."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="CRL28792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="184" mass="21127" checksum="60C2B2BA062D4675" modified="2015-09-16" version="1">MLTGCPLPSSNIEFVLRSLKLKAATLERALLISLRQGFHISDKAMTIKADNASNNDTLHRYLYQRLSQRYNEYLAETIIREGTIKFTHNSQICCFPHILNLVMNTMLRSLRAGLHKKVCDLLDDVAERSWKTVNAPTSPIAKLRLLVLWIARSPQRIQKWDNRPGCTKAINYNVDTRRNSTFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQX5</accession>
    <name>A0A0G4PQX5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
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        <name evidence="12" type="ORF">PCAMFM013_S028g000069</name>
    </gene>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="HG793161">
        <property type="protein sequence ID" value="CRL28516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQX5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PQX5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="ELO_fam"/>
    </dbReference>
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        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
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        <location>
            <begin position="473"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="482"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL28516.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="542" mass="59470" checksum="45EC034CD5F747F2" modified="2015-09-16" version="1"> </sequence>
</entry>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CRL28889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="159" mass="18311" checksum="23A22B4BB49D4EF8" modified="2015-09-16" version="1">MSSHYQESHQDDVVTHTLEEIASYTQSTFTRADLEGLGISVNEFDPLDPDFLDNRKKCLFKPYGKENMKRWKIPASEAAYESVHNRLDIQHIPLHSRLASEPTEAEIMKNEESFDLFLRFMASYPPETMNRDLSQFSIESRYLKTPNPAPSYSKACTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRB2</accession>
    <name>A0A0G4PRB2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S029g000077</name>
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    <organism evidence="1 2">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
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            <dbReference type="PubMed" id="24407037"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL28661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="269" mass="30678" checksum="5E81D7F6E9718EB0" modified="2015-09-16" version="1">MKPNPTHTSISPSRLLQLPAELRLKIYEYALDVPNEYLVSKPMIVLGDHGNTFTARGQYRALSMSPHWVGEDGTARKLLAVNRQLHNEVEDYLYSTHTLFLRNSFNLDRLGDFLDTLSATARARIRSVGFEIFFFVHTQTGVPKRTLKQYEAAARLLSEKLPLWNSVLLYLDPRYYYPSANVGGRDLTARGVFDLATRFGTLCKDVSFYPLPNGDHHLLDEAQQFVWRSRSPLRQPDGRRSIKGCSAWSLDFKKNLVAPSRVRPASSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PT33</accession>
    <name>A0A0G4PT33_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ubiquitin supergroup</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S038g000042</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
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            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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    <dbReference type="STRING" id="1429867.A0A0G4PT33"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039751">
        <property type="entry name" value="HERPUD1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12943:SF27">
        <property type="entry name" value="HOMOCYSTEINE-INDUCED ENDOPLASMIC RETICULUM PROTEIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12943">
        <property type="entry name" value="HOMOCYSTEINE-RESPONSIVE ENDOPLASMIC RETICULUM-RESIDENT UNIQUITIN-LIKE DOMAIN HERPUD PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="21"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="99"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="512"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="113"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="514"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL29639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="555" mass="61085" checksum="DF11817940291809" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PTR3</accession>
    <name>A0A0G4PTR3_PENC3</name>
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        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">PCAMFM013_S040g000034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793173">
        <property type="protein sequence ID" value="CRL29808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PTR3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PTR3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058345">
        <property type="entry name" value="DUF8032"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22949:SF0">
        <property type="entry name" value="RE27538P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22949">
        <property type="entry name" value="WHITE COLLAR 2 PROTEIN WC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26087">
        <property type="entry name" value="DUF8032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8032" evidence="2">
        <location>
            <begin position="298"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="739"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL29808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="761" mass="84137" checksum="E8D49405F344893A" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PTW0</accession>
    <name>A0A0G4PTW0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peptide hydrolase</fullName>
            <ecNumber evidence="14">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PCAMFM013_S040g000017</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M28 family. M28A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="14"/>
    <dbReference type="EMBL" id="HG793173">
        <property type="protein sequence ID" value="CRL29791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PTW0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PTW0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03876">
        <property type="entry name" value="M28_SGAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02130">
        <property type="entry name" value="PA_ScAPY_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000054">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000030">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041756">
        <property type="entry name" value="M28_SGAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF57">
        <property type="entry name" value="PEPTIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7 14 18" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 15" id="KW-0732">Signal</keyword>
    <keyword evidence="11 14" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012881525" description="Peptide hydrolase" evidence="15">
        <location>
            <begin position="16"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="16">
        <location>
            <begin position="119"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="17">
        <location>
            <begin position="233"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CRL29791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="493" mass="52828" checksum="269E58AA1D4CEC67" modified="2015-09-16" version="1">MKWLLLITHLSLALAEADRRKPLVSPDDFPSTIRLKDLLKGTQQLEDFAYAYPERNRVFGSAAHNDTVDFLYRELKKTGYYNVWKQPQVHTSTTAKTTLTVDGESIEASAMTYSPSADVTAELAVVSNLGCKASDYPSDVAGGIALVKRGECTFGEKSVLAAAAKAAAVLVYNNEAGSVSGTLGGVSSDLGPYAAIAGISDVDGKALLSAAAKGAVSLDLAIDSRIENRTTFNVIAETKGGDHNNVVSLGGHTDSVEAGPGINDDGSGIISNLVVAKALTRYSVKNAVRFFFWTAEEFGLLGSEYYTSHLSADELAKIRLYLNFDMIASPNYALMIYDGDGDAFNQTGPAGSAQIEALFENYFKSKKLSYIPTEFDGRSDYDGFISRGIPAGGLFTGAEGLKTEAQAKLFGGQANVSYDVNYHAVGDDFKNLNHEAFLINSKATAFAVAKYANNLDSIPRRNATAAKRVVKKRAPRSHAHTKKSGCFHSLVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PTZ3</accession>
    <name>A0A0G4PTZ3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S038g000024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793171">
        <property type="protein sequence ID" value="CRL29621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PTZ3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PTZ3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL29621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="201" mass="22031" checksum="93E5709EC6B0C951" modified="2015-09-16" version="1">MSTPSFAELEVAAGAVIDILKTMPEFSNSRIAVIGGLGLWNYLRRYRTTEDVDFLITVQGAPKAVKDRLLAMPSSQFQQQAQLFFYKGVGGKSIQIDITPDWQSPYVPSAAVPISAARSNALPYISELDLLVFKINCCGLRPTPAKKLRDATDARTLAEDLCSRGSINLTSAQKIAVLQGLDDVAQLSRRDKSWWVAKLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUY2</accession>
    <name>A0A0G4PUY2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S046g000037</name>
    </gene>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
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            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="CRL30233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="69" mass="7977" checksum="88500EAC2BB51390" modified="2015-09-16" version="1">MTVDHFLFRCRKWTAYRIEMLQCTHTRRSNISFFLGGKSPSDGQKWTPNLEAVRASIRFAIATGRLEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUY9</accession>
    <name>A0A0G4PUY9_PENC3</name>
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        <submittedName>
            <fullName evidence="4">Xanthine/uracil/vitamin C permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S046g000042</name>
    </gene>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:purine nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:adenine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:guanine transport"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="XANTHINE/URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
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            <end position="56"/>
        </location>
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            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
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            <end position="142"/>
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            <end position="170"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL30238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="361" mass="39707" checksum="A9ABD17A7AFB00C8" modified="2015-09-16" version="1">MYDWVHNTNLWVARSPIGRWFLLENSGHKPRKRKGSFFFTEIRAGLATFFAMAYIISVNATITSDSGGTYIYPPESQADLCNSNTAYLLCVQEVNRDIVTATAAIAALGTFFMGLLANLPVALALGIGLNAYFAYTVVGYHGSGMIPYRVALTAVFVEGFMFLGLTLLGIRQWLARALPASIKLATGTGIRLYLTLIRLTYNAGIRLVTGAVDTPIELARYVSTLRDPTTGLYPNSAKMRNLTIWIGIFCSGVLTACLMLYRVKGAIIIGILLVSVISWPRPTPVTYFPHTELSDSMFDFFKKVVAFHPITHTLAAQDWSILGHRGQFGLTFITFLYVDILDTTGTLYSMARFAGALDKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVA2</accession>
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        <submittedName>
            <fullName evidence="8">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">PCAMFM013_S044g000025</name>
    </gene>
    <organism evidence="8 9">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793177">
        <property type="protein sequence ID" value="CRL30094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PVA2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PVA2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF30">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
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    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="29"/>
            <end position="58"/>
        </location>
    </feature>
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        <location>
            <begin position="84"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL30094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="694" mass="77047" checksum="859A7DBA811F6D17" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVD4</accession>
    <name>A0A0G4PVD4_PENC3</name>
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        <submittedName>
            <fullName evidence="4">Ubiquitin-conjugating enzyme/RWD-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S052g000007</name>
    </gene>
    <organism evidence="4 5">
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793185">
        <property type="protein sequence ID" value="CRL30450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PVD4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PVD4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="3">
        <location>
            <begin position="4"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL30450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="308" mass="32746" checksum="BA6F962B381B6AF1" modified="2015-09-16" version="1">MSSPSTRRLLKESTDLHKNPSPYFTAAPISDTNLHDWHFTLAGPPSPSPYAQGLYHGRITFPATYPLRPPSFRFLTPSGRFEVNREICLSISGHHEETWQPAWGVRTALLGIRSEIFGSESQGQVGGMEGSDELRREYARLSLGWSCRECGVGNLEAMRELWGVCRERGVEVEGEVAAVDGGAGVEGQRETVEAGPDALAPASSANDVPIGSEDQTRGDGAVESTPAAESVPVPSVSAPVSAAQAQPQAPLSTIQAPAAAVIPTRTSSSQLASTESPSEGVWLDRAIIGVIVALVLLILRRVANVDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PW80</accession>
    <name>A0A0G4PW80_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase, Tc1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S056g000027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793189">
        <property type="protein sequence ID" value="CRL30654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PW80"/>
    <dbReference type="STRING" id="1429867.A0A0G4PW80"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052338">
        <property type="entry name" value="Transposase_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022:SF119">
        <property type="entry name" value="TC1-LIKE TRANSPOSASE DDE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022">
        <property type="entry name" value="TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Tc1-like" evidence="1">
        <location>
            <begin position="25"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="365" mass="43089" checksum="4153BF3B6B6048AA" modified="2015-09-16" version="1">MKEGTRSGRPTKQDTPTQEIVISKVRLDRYGREKSCADLAGDLSKLGINISAETVRRILKKSGFRKTKPTRKPGLTPAMKKARLEWALERQHWTIEDWKNVIWSDETSVILLHRRGGYRIWRTPSEAYSRSCIRERWKGSSEFMFWGCFTYDKKGPCHCWIPETVAEKREADKAIEDLNEVLEPELREQWELTNGMRRMDLRQTPGRQPQWRFNNQTGKLSRTSRGGIDWWRYQKHILIPNLLPFAKECAIDRPNTIVQEDNAPAHAHWFQKRVYDFHQVQRLLWCPNSPDLNAIEPTWFWMKRHTTKKGAPKNKAQAYTAWKTAWNELPQQRIQAWIERIPWHIQQIIACGGGNEYQEGRDKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PW82</accession>
    <name>A0A0G4PW82_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription factor, fungi</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S059g000013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793192">
        <property type="protein sequence ID" value="CRL30772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PW82"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF1">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="2">
        <location>
            <begin position="153"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL30772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="573" mass="65091" checksum="D79890AD494A8E36" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PWI6</accession>
    <name>A0A0G4PWI6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily, general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S059g000011</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793192">
        <property type="protein sequence ID" value="CRL30770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PWI6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF13">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="470"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="65"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL30770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="563" mass="61816" checksum="01A50BD80449397E" modified="2015-09-16" version="1"> </sequence>
</entry>
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    <accession>A0A0G4PXH8</accession>
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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            <end position="51"/>
        </location>
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        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="51" mass="5685" checksum="46BFF285AA9C884D" modified="2015-09-16" version="1">MQRPFTLEVTAAVDTPRSGRHVAYHYSDRFTEGGIDVPNKTTQSNPAVRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PXJ3</accession>
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            <fullName evidence="2">Alkaline-phosphatase-like, core domain</fullName>
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    </protein>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43751">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43751:SF3">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="3"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL31239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="258" mass="29430" checksum="CEAEFA64BF20D362" modified="2015-09-16" version="1">MRNLRWWSVIFVDNWLGDIMTMLDEAGISNSTLVVIVGDHGQAFGEDNKDMIGTYENGHTSNYRVPIVFRHPHMPRINIDANATSISIIPTILDLLVQSHSLDARDSEMASALLPDYQGQSLIRPFIPYIKEGHDTRIETPSDVEARSSRRTQPKVGHRTRYNWNFGIVNAGGSMVSVTAAGLPYRLVLPFKEGFEYVFSDLNQDPGELHLKLWTMKDLVDDVMSKHEASAAEWLEDAEQVGKWWVNEQRRIWGYRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PXL3</accession>
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195699" evidence="1">
        <location>
            <begin position="18"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL31141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="98" mass="10192" checksum="953389EB630BAE31" modified="2015-09-16" version="1">MRLNLPLVLGMATSASALWSVTYYTASDCSGAGKEIGGFEAGCQALETGTKSVMVSTDSGNNITLSTGINCNSPYEDPIPSEVTGRCVNAAIRSFLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PXU8</accession>
    <name>A0A0G4PXU8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S065g000009</name>
    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PXU8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021842">
        <property type="entry name" value="DUF3435"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11917">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL30959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="58" mass="6723" checksum="C639C7595439EEAD" modified="2015-09-16" version="1">MLVLSPYIFLLGILFRIGVFKSLLKDGPIMDCPEKLYRLWILDGLGEQELKLKDEILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PY37</accession>
    <name>A0A0G4PY37_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EF-Hand 1, calcium-binding site</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S118g000002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793249">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PY37"/>
    <dbReference type="STRING" id="1429867.A0A0G4PY37"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL31324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="385" mass="44199" checksum="43CE02E10ECCFF31" modified="2015-09-16" version="1">MEMENDGEKIAGKRVPLKRSRMDFEDDDESTEDYSEYNRSDKDEGGWRTENDSKDSNDEQEIEEHEYTTSDDPARPIKIRLFLADEGFSESKWMKNFVAECTCDGITVANALARMEEPSEETCDVAFHIFDRYGTVQAKCKDHPVQRGTGIWGNEIDHGPFFLLEKLHVTALELRRKGLGRKVVSLLLEKAKKFLQHERPDGEDADLIYSSDEAFERAWTLHALVSPGYLTADIEPQLKGKSAEERLTTKYRNQSGAIDFWRSCGFRRIGASRCFALSFDLQHQSRALAEVCDFDPRRSNAEDLENEELEMIYEADSWTNVKELKMERLRDVLSLHHASLTLTDKELRAFFIAHANDKIGWDRVTNSEATLLHLTACEIKPLSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PY73</accession>
    <name>A0A0G4PY73_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S3Jg000039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793312">
        <property type="protein sequence ID" value="CRL31428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1429867.A0A0G4PY73"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF2">
        <property type="entry name" value="LYTIC POLYSACCHARIDE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195830" evidence="2">
        <location>
            <begin position="21"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL31428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="274" mass="29342" checksum="66BB966525B39CFA" modified="2015-09-16" version="1">MILVTWCLLLQAVAFSPTYAHLRMTSPEPYGSSRKTLDNSPLAADGSDFPCKISPGDFIVPTEEATYRTGSNNSIKLLGSATHGGGSCQVSLTSDREPTKNSEWKVIKSYEGGCPAKGPGNLDGSAESDHSLQLHFAIPDGIAPGKYTLAWTWFNRIGNREMYMNCAPITVANESPSNSSDNTPKQSLDFPPMFIANVNGCITRENVDIHFPWPGSIVEYNGDSKYRPQEGEPVCTGNPTFGPIPITDTADTGEASSTTENANSMPCSCGCQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PYG1</accession>
    <name>A0A0G4PYG1_PENC3</name>
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        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PCAMFM013_S4Jg000060</name>
    </gene>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793313">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="81"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL31538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="516" mass="58916" checksum="43921B9E89CE13F9" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PYS4</accession>
    <name>A0A0G4PYS4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S4Jg000068</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL31546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="313" mass="34213" checksum="732FBC7B48C5DB52" modified="2015-09-16" version="1">MKIVVGAYSLLSVLEGFKLPFSHSSRISTRSMRCESESPIGANGLWKTVNSQSSISIIFTTGRMPNVGSLGSIATTLMEKHIGFSSAYLLDLCAVILCVFIVQVAKSRFVHPPVQGSKLPRAARCLWYAVRGGFKLNAALPQYQLETHGRVVRWDKELLQSCGMPCQLLKSGAIGWPIFWVCMGEGAQVSISQAGQVETHGIPNDLIKSANPIAYVIFGPIVQKQLYPFLQKRRIAFHAVDRIPLGFVIMSVAMAYSAVVQAFIYRTGPCYSHPLACGASDSGQVPNRTHVLWQLPHLHHHCTSGSVLLAHGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NTS2</accession>
    <name>A0A0G4NTS2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">PCAMFM013_S001g000418</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NTS2"/>
    <dbReference type="STRING" id="1429867.A0A0G4NTS2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL17458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="270" mass="30062" checksum="93C1A707F8E37A5F" modified="2015-09-16" version="1">MDDKQSNLWIYRGRTDDMLVLSNGEKVRPVAMEAIINSHPAVGSCLVHHGEIPYCKHGYKQARLFREYIWFAKPSKPFVRTDKSTVKRRDTVVLNEKEIEQFYKSMEEDGKLAANIDIASLATISESVHHLLTVAAAGVDPLVAFSISNSLRSSLGKYNVSDERKLAVTPRFAYTHPTISALTKVLYNLVCNNMSCSAETSVDLQRKTADRFRAKYTAGLGGGHTVILTGRTGSLGSYLLESLDQGMKSLLSQPNRRRKGSRRQQVNPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NUG4</accession>
    <name>A0A0G4NUG4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S001g000697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NUG4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL17737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="430" mass="50105" checksum="38639649495AAFB0" modified="2015-09-16" version="1">MLIVQLFCLAQSTKMHDIPINTILQTWYFTLRCERLEQMLVSMKEITTPFIPQQRLKLLRIDINHLDINSGITSPSVIRYFMPRTDTPKVEKIRPDPDWDWFLSQKGNFGKGTFRANYLLRRVFMDYQDSSVPEFWPYELDGTRSEEKENNEDPTVRGSGHPDNIKHDKVGDTKDNLDDKEVSEDKEGKSMDPEKHDESCKDDDNSKERGNRTRKPSDESHEKGDESESEKSDKEADGNHEMVIAKALDLNIRNYRTDDWLVYWTQTLYDLDLPDKTHGISIARSMELDHPHKCHAWALVDVILCGHDRPSTAELIALVNWGLRGMLHQLESLANETEPENVHLLNEVFPTMIIVFDQRYCARVLYGYFDGRFQVLFTPVLNFKEFAQVSSSSLDGYMGQIDKKKYYDMMHTLLRWAWPLCHHLTTIAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NVF8</accession>
    <name>A0A0G4NVF8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S001g000995</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL18035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NVF8"/>
    <dbReference type="STRING" id="1429867.A0A0G4NVF8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF37">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="10"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL18035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="597" mass="67329" checksum="EC05526A4E6AE278" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NW63</accession>
    <name>A0A0G4NW63_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Synaptobrevin, metazoa/fungi</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S002g000089</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NW63"/>
    <dbReference type="STRING" id="1429867.A0A0G4NW63"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15874">
        <property type="entry name" value="R-SNARE_Snc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000063">
        <property type="entry name" value="Synaptobrevin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="SYNAPTOBREVIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005409">
        <property type="entry name" value="Synaptobrevin_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="30"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL18219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="119" mass="12981" checksum="D513AA2AD8B5139D" modified="2015-09-16" version="1">MAASEQPYDPYIPSGSAGAPAATGQNGNQRTAALQAQIDDTVGVMRENINKVSQRGENLDSLQDKTDNLAVSAQGFRRGANRVRKDMWWKDMKMRVCLVICVIVLLIVIIVPSVVATKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWA5</accession>
    <name>A0A0G4NWA5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S002g000205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWA5"/>
    <dbReference type="STRING" id="1429867.A0A0G4NWA5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926">
        <property type="entry name" value="F-BOX DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926:SF72">
        <property type="entry name" value="IM:7136021-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="661"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL18335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="685" mass="77367" checksum="AD55770A5F298620" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWC1</accession>
    <name>A0A0G4NWC1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S002g000257</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWC1"/>
    <dbReference type="STRING" id="1429867.A0A0G4NWC1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005194838" evidence="3">
        <location>
            <begin position="19"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL18387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="270" mass="28213" checksum="50A303FA7E3814A6" modified="2015-09-16" version="1">MVPRSLLHLSIFASLVAASKQCYFPSGAVALDDVPCFSGDADSPCCSKDSICLSNGLCYGISQPYTLSRGSCTNKNWPADGGCDDKCSDATDMRNKGCALPFSHILDEKPYYCANSVVVNSSGDLACYAGSPFTLNSGELVSGKAALANYTTSGTSSNSTSDSSTTACPTTPSDENKGGNDNTEWKKVNNAVVIGAGVGVPLGVLLLTALGWALFERRKRLSAQALVAGLQSQAAATTTYLDRPGQQSGYSPPSELSAYKPPQELETTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWD2</accession>
    <name>A0A0G4NWD2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">U box domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S002g000272</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWD2"/>
    <dbReference type="STRING" id="1429867.A0A0G4NWD2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045862">
        <property type="term" value="P:positive regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46803">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46803:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="6" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="2"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="U-box" evidence="7">
        <location>
            <begin position="214"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL18402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="290" mass="32482" checksum="EB74D45D29BDFCA5" modified="2015-09-16" version="1">MAQELKSKGNELFKSGDYSGAEDFYSQAIQKNPKDATFFTNRAITRIKLAKWADVEHDARAAIEIYGLKNPVALKSHYYLAQALLGLQRPQEAHDVASDAYKQSLAAKNAQTENLSRTVLRAKQQLWAARETSRVRETSRVRELNETLGSVEALVEADVTRALAELQGRLERGEIGEIGFGEDQKALREDAETKVRNLREAFRVASKGDIQERVVPDYLIDGITFEIMHDPVITPSGVSFDRLGITKYVEKSGVDPLTRAPISVHDLRNNYALKAACEEFLTNNGWAVDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWE1</accession>
    <name>A0A0G4NWE1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S002g000236</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWE1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL18366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="68" mass="7514" checksum="23A97A6FBB1724BA" modified="2015-09-16" version="1">MFSINATDFPHSSGFCEASSGEFAHQEALRAGQANALVCLDVLTNDKFAEEMKKEFIEAMKEAGRWEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWU4</accession>
    <name>A0A0G4NWU4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase, DXD sugar-binding region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S002g000259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWU4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF8">
        <property type="entry name" value="TRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL18389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="315" mass="35251" checksum="EC6DD9B7845B7E73" modified="2015-09-16" version="1">MLARGPSFTKFSTTTIFILTCLFFILYYHPMRLATPEGPSEYDTSRKGFQPASPRIPEKIWYKVGPKGLSDQSHEWLDDCLHKNPAHSAQIMTDLTGDQYVEQNFGHRPDIVHAYLSLSVPILKADFLRYLLLFIEGGIWADLDVSCGDVPIREWIPETIRAKAGLVVGWEFDVGWGDSFIRQFESWTIMAAPGSPHLLMVIDDIMEGIRQKTGEYGVPVSGLTLEMTGDVIDFTGPRRLTRGVLKSLELVRNETIDMASISNLLEPVLVEDVLILPGYSFAATSNTYSNENVTGPSLVQHHYAGSWKNHNGGEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXB2</accession>
    <name>A0A0G4NXB2_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14 15">Diphosphomevalonate decarboxylase</fullName>
            <ecNumber evidence="3 14 15">4.1.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PCAMFM013_S002g000628</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(R)-5-diphosphomevalonate + ATP = isopentenyl diphosphate + ADP + phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:23732"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.33"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:23733"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 15">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14 15">Belongs to the diphosphomevalonate decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.33" evidence="3 14 15"/>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NXB2"/>
    <dbReference type="STRING" id="1429867.A0A0G4NXB2"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004163">
        <property type="term" value="F:diphosphomevalonate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000018">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000005">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005935">
        <property type="entry name" value="Mev_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029765">
        <property type="entry name" value="Mev_diP_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053859">
        <property type="entry name" value="MVD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041431">
        <property type="entry name" value="Mvd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01240">
        <property type="entry name" value="mevDPdecarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977:SF3">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18376">
        <property type="entry name" value="MDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22700">
        <property type="entry name" value="MVD-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015950">
        <property type="entry name" value="Mev_P_decrbx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11 15" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8 15" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-1207">Sterol metabolism</keyword>
    <feature type="domain" description="Diphosphomevalonate decarboxylase-like N-terminal" evidence="17">
        <location>
            <begin position="16"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Mvd1 C-terminal" evidence="16">
        <location>
            <begin position="202"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR015950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF18376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CRL18758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="404" mass="43243" checksum="802AFD8D59A4117A" modified="2015-09-16" version="1">MASTSNQSVYRATTTAPVNIAVIKYWGKRDTTLNLPTNSSLSVTLSQRSLRTLTTASCSAEYPPADTLNLNGSPQDIQSSKRTLACISNLRALRKALEDADSSLPKLSAHPLRIVSENNFPTAAGLASSAAGFAALVRAVADLYELPQSPKDLSRIARQGSGSACRSLMGGYVAWRTGELADGSDSLAEEVAPASHWPEMRAIVLVVSAEKKDVPSTEGMQTTVATSALFAERAQNVVPERMAAIETAIQNRNFHDFAEITMRDSNTFHATCLDSWPPIFYMNDVSRAAVRLVHDINRAAGRTVCAYTFDAGPNAVIYYEDKDSEVVAGTVKAILGSNTEGWDGAFYERVANVTAGVALDQVDSRAVEVLKEGVSRVILTGVGEGPVKVEDHLVSETGEILSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXG7</accession>
    <name>A0A0G4NXG7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Basic-leucine zipper (BZIP) transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S002g000677</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NXG7"/>
    <dbReference type="STRING" id="1429867.A0A0G4NXG7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BZIP" evidence="5">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="204"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="234"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="304"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="112"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL18807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="341" mass="36363" checksum="89E3DCC9FD8E4188" modified="2015-09-16" version="1">MMEAKKKSNSSVEHRRAQNRLAQRRFRQRQSQQKAKADQPLQQTLDTPISATGNSSDIFKFSTGTWPTPPSPIKSPGGSIGFGVNCLHGGANGLIGIQNFINMDDLKDSPLSTLLAGPSPSISNTGSAEHTLSSSDQGSNSKHPSPLASRGESSGTHRTTPDSFDTSSLPKALTDKLTPASAGSVSALFPGTTQCDDADLGCLSALHIAAQKGHHGIMRVLLQQDINCDEIDSDGLTSLIHATIGGHEDIVTLLLIHGARIDKVDRQGRSVLHFAVTYRREGILKILLDYCVGDQRFIDAYDSGGRTPLHIAVDAGFEEGVQVLLQRGASVHCKTRKTGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NY62</accession>
    <name>A0A0G4NY62_PENC3</name>
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        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">PCAMFM013_S002g000875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL19005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4NY62"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR42088">
        <property type="entry name" value="YALI0F10131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42088:SF1">
        <property type="entry name" value="YALI0F10131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL19005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="668" mass="72771" checksum="C81F7C8E3947601E" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZM7</accession>
    <name>A0A0G4NZM7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SNF2-related</fullName>
        </submittedName>
    </protein>
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        <name evidence="11" type="ORF">PCAMFM013_S003g000255</name>
    </gene>
    <organism evidence="11 12">
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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                <person name="Giraud T."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF52">
        <property type="entry name" value="SINGLE-STRANDED DNA-DEPENDENT ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="376"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="694"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="780"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL19464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="939" mass="107185" checksum="4D55622834E7358B" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZU1</accession>
    <name>A0A0G4NZU1_PENC3</name>
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        <submittedName>
            <fullName evidence="11">Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S003g000359</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the 2nd section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the shikimate kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4NZU1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000019">
        <property type="entry name" value="Quinate pathway repressor protein QutR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002254">
        <property type="entry name" value="Quinate pathway repressor protein QutR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000386">
        <property type="entry name" value="Quinate repressor protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
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        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
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        <property type="entry name" value="DHquinase_I"/>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
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        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090">
        <property type="entry name" value="AROM/DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090:SF27">
        <property type="entry name" value="QUINATE REPRESSOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01100">
        <property type="entry name" value="SHIKIMTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="9">
        <location>
            <begin position="565"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase" evidence="8">
        <location>
            <begin position="707"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="SDH C-terminal" evidence="10">
        <location>
            <begin position="847"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="882"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="882"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="895"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL19568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="904" mass="99914" checksum="089BE597A8FC2198" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P094</accession>
    <name>A0A0G4P094_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lactase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S003g000547</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="HG793136">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P094"/>
    <dbReference type="STRING" id="1429867.A0A0G4P094"/>
    <dbReference type="UniPathway" id="UPA00280"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005990">
        <property type="term" value="P:lactose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000018">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004199">
        <property type="entry name" value="B-gal_small/dom_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050347">
        <property type="entry name" value="Bact_Beta-galactosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032312">
        <property type="entry name" value="LacZ_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46323">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46323:SF2">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02929">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16353">
        <property type="entry name" value="LacZ_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01038">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Galactose mutarotase-like"/>
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    </dbReference>
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        <property type="entry name" value="Galactose-binding domain-like"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta galactosidase small chain/" evidence="7">
        <location>
            <begin position="744"/>
            <end position="1029"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL19756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1036" mass="117253" checksum="505E4338454FA402" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0F5</accession>
    <name>A0A0G4P0F5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aromatic-ring hydroxylase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S003g000559</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P0F5"/>
    <dbReference type="STRING" id="1429867.A0A0G4P0F5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972:SF1">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972">
        <property type="entry name" value="MONOOXYGENASE ASQM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="19"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="317"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL19768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="422" mass="46974" checksum="E0D9E7CD1845C018" modified="2015-09-16" version="1">MCTSPSKRLPPNMESFPKIAIIGGGPAGLTLANILQKNSIPFSLFEHDTSPNERNQGGTLDLHPKAGQAALREAGLWDEFIQHARPEGDVLKVVKQDGTVLRDGNTSQPPVQNDKSMSNRPEIDRAKLKDILLQHLDGKNVHYDKTLASAVPGGRTDTWNLHFRDGSVEKDFDLIVGAEGAWSHTRKLLTDVEPFYSGITAIELWALDVNQHHPWMVNYVGRGSLFSFDADRAILIQRIGDGSIRTYACLRVPEGFIKDCGIDWTQPDIARKELVERYYNDSGMELKRMILESTDELIPRPLYMLPVGIKWDPRPGVTLLGDAAHLMTPFAGVGVNAAMLDALELGNTLVSLKMGKFPSLNKAIEKYERELFPRGQKFAQKTVNNMETHFSADGCNQLVWRLRIGYGFLAIASAVSRWIPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0H6</accession>
    <name>A0A0G4P0H6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S003g000575</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P0H6"/>
    <dbReference type="STRING" id="1429867.A0A0G4P0H6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF3">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="11">
        <location>
            <begin position="76"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="264"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL19784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="823" mass="92987" checksum="4BD2A2AD0C895204" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0R3</accession>
    <name>A0A0G4P0R3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S003g000655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P0R3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL19863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="60" mass="6578" checksum="9246E80A1092EB70" modified="2015-09-16" version="1">MKLPLALHEIRDNRRQQEAILGRTSLSGCSHGLFSPRHSRELAGSPFPLMGESSVASLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0V2</accession>
    <name>A0A0G4P0V2_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Delta-1-pyrroline-5-carboxylate dehydrogenase</fullName>
                <shortName evidence="10">P5C dehydrogenase</shortName>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="9">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
                <ecNumber evidence="9">1.2.1.88</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S003g000742</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-glutamate 5-semialdehyde + NAD(+) + H2O = L-glutamate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="9"/>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P0V2"/>
    <dbReference type="STRING" id="1429867.A0A0G4P0V2"/>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:L-glutamate gamma-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000006">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000005">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050485">
        <property type="entry name" value="Proline_metab_enzyme"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862:SF1">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 9" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="11">
        <location>
            <begin position="78"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL19950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="568" mass="62841" checksum="FA9626B2AA359F1A" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P177</accession>
    <name>A0A0G4P177_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S003g000831</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL20039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P177"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045016">
        <property type="term" value="P:mitochondrial magnesium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12823">
        <property type="entry name" value="Mrs2_Mfm1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039204">
        <property type="entry name" value="MRS2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890:SF0">
        <property type="entry name" value="MAGNESIUM TRANSPORTER MRS2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890">
        <property type="entry name" value="RNA SPLICING PROTEIN MRS2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22099">
        <property type="entry name" value="MRS2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005194958" description="Magnesium transporter" evidence="11">
        <location>
            <begin position="20"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL20039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="355" mass="40711" checksum="D8D23148284A96E7" modified="2015-09-16" version="1">MRRRAVTILLSFFLRGRLSKYKTTPQCQFHHLSGTLRTKQPKIPNIPSYRRRGIITLPNKSHHVIQEPDMKKEASFNQNVFNLSLALSQSRRNDAMELRCIILGPDGSIKESEVRKTRDDLAKQWGLDGRDLRNVDLVSEGIPHLLDCHVKVQDVFMADLQSRLRHAPGSGVLAKLPFELRVVDAALASVIATLEAEHILIRREVEDSLRDSTREDVVYSVLRGLQDHRKRLVAIQQRARQFRSALREILENDEDMAAMFLTDRQAGQLHEVEDHLEVEYLLEAYYKNTDAIAESASALLGDVERTTETIQSILAVRRNQILVFEAQLEILCVIGTVTIAKYGLWKLNKFRKLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P1L6</accession>
    <name>A0A0G4P1L6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S004g000157</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P1L6"/>
    <dbReference type="STRING" id="1429867.A0A0G4P1L6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052761">
        <property type="entry name" value="Fungal_Detox/Toxin_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425:SF2">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="72"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL20217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="319" mass="35828" checksum="FBD9EAE3AC511D0A" modified="2015-09-16" version="1">MGTEYRFEHTLQESASGNETMPYQRVEKKFRPRRAKWACYACHKRKVRCDALNQGTSCTNCRLDMKECVAPPRRKKRTTAPTPYTPGEARADNTPQSPHISQPPTIPDSKCNDVQSNNADASSRKRKSEPQSLISPCTSPQKVQRAGEDSLHGVDNEVGLWMEMLPPNIPEQLELRSTKDISRPHRDTIDGLNPEQFHHKCSEKLLQAVDILTEVIIMHNSLSTHNTESSVPTIHPAADIHSIENQIDDDALKKDNMEYSSVCHRVGENIWDTETTLDASSALTPESLEFVAASNYNIWLELNDFDLDGPSSLGSYDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P1M4</accession>
    <name>A0A0G4P1M4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fps/Fes/Fer/CIP4 homology</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S004g000124</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1429867.A0A0G4P1M4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07652">
        <property type="entry name" value="F-BAR_Rgd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000063">
        <property type="entry name" value="Rho GTPase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000041">
        <property type="entry name" value="Rho GTPase activator (Rgd1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF136">
        <property type="entry name" value="RHO GTPASE ACTIVATOR (RGD1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-BAR" evidence="6">
        <location>
            <begin position="40"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="5">
        <location>
            <begin position="462"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="346"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="141"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="362"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="380"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="412"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL20184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="655" mass="71450" checksum="D57E4FB30CD3FCB1" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P1T4</accession>
    <name>A0A0G4P1T4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Beta-xylanase</fullName>
            <ecNumber evidence="10">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S004g000173</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15 16">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P1T4"/>
    <dbReference type="STRING" id="1429867.A0A0G4P1T4"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000094">
        <property type="entry name" value="Endo-1,4-beta-xylanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031158">
        <property type="entry name" value="GH10_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF76">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00591">
        <property type="entry name" value="GH10_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195101" description="Beta-xylanase" evidence="11">
        <location>
            <begin position="24"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="12">
        <location>
            <begin position="50"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL20233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="315" mass="34268" checksum="6EE268CD79FFBD81" modified="2015-09-16" version="1">MFPNMIQVKTAALVMLFAGQVLSGPVESRQASVSIDAKFKAHGKKYLGTIGDQGTLSKNAKTPAIIKADFGQLSPENSMKWDATEPNQGQFSFTGSDYLVDFAQSNDKLIRGHTLVWHSQLPSWVSSISDKTTLTNVMKNHITTVMNHYKGKIYAWDVVNEIFNEDGSLRDSVFYNVLGEDFVRIAFETARAADPNAKLYINDYNLDSASYPKLSGMVSHVKKWVAAGVPIDGIALNALASAGTKEVAITELDIAGASSTDYVNVVKACLNQPKCVGITVWGVADPDSWRSSESPLLFDGNYNPKDAYNAIANAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2S6</accession>
    <name>A0A0G4P2S6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S004g000568</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P2S6"/>
    <dbReference type="STRING" id="1429867.A0A0G4P2S6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06087">
        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S4"/>
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        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Rib_uL2_dom2"/>
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    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_eS4"/>
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        <property type="entry name" value="Ribosomal_eS4_C"/>
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        <property type="entry name" value="Ribosomal_eS4_central_region"/>
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        <property type="entry name" value="Ribosomal_eS4_central_sf"/>
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        <property type="entry name" value="Ribosomal_eS4_KOW"/>
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        <property type="entry name" value="Ribosomal_eS4_N"/>
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        <property type="entry name" value="Ribosomal_eS4_N_CS"/>
    </dbReference>
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        <property type="entry name" value="S4_RNA-bd"/>
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        <property type="entry name" value="PRK04313.1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="40S_S4_C"/>
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        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002116">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S4"/>
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        <property type="entry name" value="RIBOSOMAL_S4E"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="8">
        <location>
            <begin position="41"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL20627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="260" mass="29273" checksum="E4AC4B7FE0EB125D" modified="2015-09-16" version="1">MRGPGKHQKRLSAPSHWLLDKMSGTYAPKASPGPHKLRDCLPLIVFIRNRLKYALNGREVKAIMMQRLVKVDGKVRTDTTYPAGFMDVISLEKTGEHFRLVYDTKGRFTVHRIQAEEAEFKLCKVKRVQLGKGGIPFLVTHDARTIRYPDPAIKVNDTVKVDVATGKILDFVKFDSGVVIMATGGRNMGRVGVITHRERHDGGFNIVHVRDALDNQFATRESNVFVIGQDKPWVSLPKGKGVKLSIAEERDRRRAHELAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3F4</accession>
    <name>A0A0G4P3F4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATPase, AAA+ type, core</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S004g000769</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P3F4"/>
    <dbReference type="STRING" id="1429867.A0A0G4P3F4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051228">
        <property type="term" value="P:mitotic spindle disassembly"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19519">
        <property type="entry name" value="RecA-like_CDC48_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19528">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000012">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="7">
        <location>
            <begin position="43"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48" evidence="6">
        <location>
            <begin position="143"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="255"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="529"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="729"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="797"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="740"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL20827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="820" mass="90307" checksum="8682C686A2F44A44" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P4E5</accession>
    <name>A0A0G4P4E5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S005g000344</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P4E5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050563">
        <property type="entry name" value="4-hydroxybenzoyl-CoA_TE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31793">
        <property type="entry name" value="4-HYDROXYBENZOYL-COA THIOESTERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31793:SF39">
        <property type="entry name" value="THIOESTERASE_THIOL ESTER DEHYDRASE-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL21180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="301" mass="34470" checksum="3D254312C66F9ED6" modified="2015-09-16" version="1">MLPQPAFRVQLSASISLYSNGTRRLFSATSASLNGQNIPIPDSVSTPINPRWLTMTKRRVGKCMMFGMKPAQIDEGGKILQQLAKEWRELLAGSEGFLTDKKRRSLYRHNVVWGEQSACGGLGYYGHVNNVTYVRYAETARVNWTRNIGNHIDTANKKEWINMLGNTGIGLILKSIKVDYKFPMESPDKITVYQKLIPDPSRHLSAQSAFRLEVMILSEAHQRPAARCFEDIVIYDYKKNRKTVNIPPFVMEQFETMWKQQEQDEVNWRQRIADIENRVRNLELGSWDRADAVEDNGSASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5Z7</accession>
    <name>A0A0G4P5Z7_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein MAK16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S006g000281</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the MAK16 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P5Z7"/>
    <dbReference type="STRING" id="1429867.A0A0G4P5Z7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.110:FF:000001">
        <property type="entry name" value="Protein MAK16 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006958">
        <property type="entry name" value="Mak16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405">
        <property type="entry name" value="MAINTENANCE OF KILLER 16 MAK16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405:SF4">
        <property type="entry name" value="PROTEIN MAK16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04874">
        <property type="entry name" value="Mak16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003352">
        <property type="entry name" value="MAK16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="6">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="203"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="209"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR003352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL21741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="320" mass="37197" checksum="90EBD2DEB1FB733F" modified="2015-09-16" version="1">MSDEIVWQVINQQFCSYKLKTTKDQNFCRNEYNVSGLCNRQSCPLANSRYATVRSDPETGVMYLYMKTVERAHMPSKWWERVRLSSNYAKALEQVDERLIYWPKFLTHKCKQRLTRLTQVSIRMKNIAKEDERLGEKVVPKLAPKVRRREETRERKAESAAKVERAIERELIERLRSGAYGDRPLNVEEGIWKKVLRGLERAGDGERDVDMDDGEELEEEEEEGVGEVEYVSDLDEEEDLEDMEDWLGVDSADSSDYDDDESDDDDDDSEDDEEASEDEKKPKPSAKRKHVAPQAKPRKKGPRIEIEYETEGAGKDQLMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P600</accession>
    <name>A0A0G4P600_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nascent polypeptide-associated complex subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Alpha-NAC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S006g000258</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. EGD2 may also be involved in transcription regulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Part of the nascent polypeptide-associated complex (NAC), consisting of EGD2 and EGD1. NAC associates with ribosomes via EGD1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAC-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P600"/>
    <dbReference type="STRING" id="1429867.A0A0G4P600"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005854">
        <property type="term" value="C:nascent polypeptide-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22054">
        <property type="entry name" value="NAC_NACA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14358">
        <property type="entry name" value="UBA_NAC_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000002">
        <property type="entry name" value="Nascent polypeptide-associated complex (NAC), alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000006">
        <property type="entry name" value="Putative nascent polypeptide-associated complex subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016641">
        <property type="entry name" value="EGD2/NACA0like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21713">
        <property type="entry name" value="NASCENT POLYPEPTIDE ASSOCIATED COMPLEX ALPHA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015901">
        <property type="entry name" value="NAC_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NAC-A/B" evidence="13">
        <location>
            <begin position="45"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="135"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="148"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CRL21718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="202" mass="21849" checksum="AFF4CCF1A983B227" modified="2015-09-16" version="1">MADPRVEEIHDDEVSKTVEESSSESGSEAGDEPNIPAGASVAVHSRGEKKARKAIGKLGLKLVPGITRVTLRRPKNILFVVNQPEVYRSPNSNCWIIFGEAKIEDLNSQAQASAAQQLAASEAAGDHAGHDHEEVLGKAKAPETEDKKEDEEDDGEEVDESNLESKDIELVMAQANVSRKKAVKALRENDNDIVNSIMALSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6D6</accession>
    <name>A0A0G4P6D6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S006g000423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyketide transferase af380 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P6D6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051411">
        <property type="entry name" value="Polyketide_trans_af380"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751:SF1">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL21883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="49" mass="5268" checksum="C2FA8A806C77E34F" modified="2015-09-16" version="1">MTGVKEQTSADHARALSTTGFYALTFDAGYQGESTGQPRGLEDPLYQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6S7</accession>
    <name>A0A0G4P6S7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CDR ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S006g000464</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4P6S7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="484"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="518"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="551"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="661"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1119"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1160"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1197"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1233"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1336"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="61"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="748"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="690"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="715"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL21924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1365" mass="151956" checksum="9F57EE47E62553F4" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7S5</accession>
    <name>A0A0G4P7S5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S007g000336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P7S5"/>
    <dbReference type="STRING" id="1429867.A0A0G4P7S5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF54">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="58"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL22355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="281" mass="32479" checksum="CCB30F3D11C2D945" modified="2015-09-16" version="1">MPGPEKEEPVQALDGGPQINILFSAPDFTVPCPDSGGVKIARISPEIVVKFGSHVTLAEAKNMMFAKQNTETLPVPKIFACYSYGPINRDIEDHGSLFDTYIFMSFVESQTLDKVWESYDEDTKAHVTNQLKEYLLELRQIRNGSYIGSANSGPVTDQILESYHDRLTLRKIFNNAIIDAYQSKAPKRQIKNFLSGMLCQNNHQIVFTHGDLRLQNIMVNDGSVSGILYWEFSGWYPEYWEFLKALYIWQWQNDWTDYLVQILRPYYAEYTIHCFLTETLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P832</accession>
    <name>A0A0G4P832_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclin-like F-box</fullName>
        </submittedName>
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            <end position="358"/>
        </location>
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        <location>
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            <end position="680"/>
        </location>
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        <location>
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            <end position="758"/>
        </location>
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            <end position="628"/>
        </location>
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            <end position="641"/>
        </location>
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        </location>
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            <end position="741"/>
        </location>
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            <end position="758"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL22873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="758" mass="84689" checksum="671B057C5ABBF140" modified="2015-09-16" version="1"> </sequence>
</entry>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <authorList>
                <person name="Cheeseman K."/>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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                <person name="Abraham A.L."/>
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                <person name="Lacoste S."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
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            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
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            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
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            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="540" mass="62054" checksum="9850CF3BFEF11B53" modified="2015-09-16" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Dupont J."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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            <end position="75"/>
        </location>
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        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="192" mass="22767" checksum="97B161447FE2BCD2" modified="2015-09-16" version="1">MPKPRWPRAEADNLLPWLSRHQHLSWKKKSAAYMKEYGIHRSGESLRGKQNQMEDEARQLKGGSFPSSTLHRPSLALRTPNPRVRRLLHQLRRRQHPSFKNSSRKSNQKRFGQLRIIYHSAAMKQGLIDGEMPLGCQQFRICRYQHPRIIACFWKFIHRRAAAGTLKGFRDLCLILSKCKVEYMDFTWYYTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PA63</accession>
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        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
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    </organism>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CRL23190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="329" mass="36785" checksum="0DCAE27587472E28" modified="2015-09-16" version="1">MKYRGVVYDVGLRFGDQGFSVEPFDPILVEHDMRVIANDMHANAVRIEGEEIHRLESAAQAAHSMGLTVFFNPWKMNEGVDIVFVAGCEYTIFSKGVFPGESFYERAMWLGTQFPGGHMTRDVPQVLRDKSVELNKVLRSFVKVIRAKFGGLLTYSAGTWELVDWDIFDIVGIDYYRRGEAEEEYVAGLEHYRFGKPLAVMEVGCCAYEGAAGRGDGGFMLLKSTNPDGSGVFEGGVVPTRSEREQADYLGTQLNLLAAADVHAVFVYVFSVPCMRRGEGPSDLDMMCFSLVKYFPDGDPRSNAMPPWTPKESFHRVADFFLSMVQPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAM6</accession>
    <name>A0A0G4PAM6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA-binding protein VTS1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">RNA-binding protein vts1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S009g000264</name>
    </gene>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">RNA-binding protein involved in post-transcriptional regulation through transcript degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer. Binds to RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PAM6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09556">
        <property type="entry name" value="SAM_VTS1_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000033">
        <property type="entry name" value="Protein vts1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050897">
        <property type="entry name" value="SMAUG/VTS1_RNA-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057327">
        <property type="entry name" value="Vts1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037635">
        <property type="entry name" value="VTS1_SAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515:SF5">
        <property type="entry name" value="PROTEIN SMAUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25479">
        <property type="entry name" value="Vts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
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            <end position="598"/>
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            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
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            <begin position="255"/>
            <end position="314"/>
        </location>
    </feature>
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            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
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        <location>
            <begin position="442"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="508"/>
            <end position="539"/>
        </location>
    </feature>
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            <begin position="8"/>
            <end position="31"/>
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            <end position="283"/>
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    </feature>
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            <end position="314"/>
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            <end position="413"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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            <dbReference type="EMBL" id="CRL23324.1"/>
        </source>
    </evidence>
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        <source>
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    <sequence length="608" mass="65498" checksum="6AD32E70C76C2C68" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PB02</accession>
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        <submittedName>
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        </submittedName>
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        <name evidence="6" type="ORF">PCAMFM013_S009g000415</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
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            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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        <location>
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    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="471" mass="50307" checksum="D038BE4ECB9B3ACA" modified="2015-09-16" version="1">MQKSATASVPEPVQEPWQSSSTSVAEYPTSYPTGHNSNFDEEAPRSAFSVVEPPAELSTLTTHLTGHSTDDTFPDGGLQAWCVVAGSFCLLMGTFGVMNTTGILQNYFATHQLASYSPSAVGWIPGLFTFFGLSISVQVGPMFDRYGPRGILIAGTICYVTGFILLAESHLYWHFVLTLGVLSGTGAALLSTVALASVPQWFDRKAALAIGISMSGAGLGGVIFPFVLRAGFTNLGYKWTIRLMALLVLILGVLGTVLVKARLPKGRSKSTINLRSLQDARFTWLTFGIFALELEVFAGLGLYPTYVIMQGFSTNTSVVLLAVQNVASTIGRLVAGGVADRFGRINTQTGLIALGAFAVFVIWLPFGNSLAGLYVFSVIFGLASGSFLSLAPACIGQISRASEVGGRFGLTYSIVSFATLICIPIGGEMLDKVGKRAMVAYLGSVLIVSLGLFVMARWACLSYRWRWQAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PB53</accession>
    <name>A0A0G4PB53_PENC3</name>
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        <submittedName>
            <fullName evidence="12">Beta-ketoacyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S009g000493</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:fatty acid synthase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ligase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="P:lactone biosynthetic process"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
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        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Polyketide synthase type I"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
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        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
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        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF20">
        <property type="entry name" value="HYBRID PKS-NRPS SYNTHETASE APDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="8"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="11">
        <location>
            <begin position="948"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="2391"/>
            <end position="2468"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="7">
        <location>
            <begin position="948"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="7">
        <location>
            <begin position="1095"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2535"/>
            <end position="2566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="2543"/>
            <end position="2558"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="7">
        <location>
            <position position="980"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="7">
        <location>
            <position position="1155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL23553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="3023" mass="332871" checksum="216881BDA1B1E70E" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PB86</accession>
    <name>A0A0G4PB86_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Transfer RNA methyltransferase 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TRM8</name>
        <name evidence="11" type="ORF">PCAMFM013_S010g000020</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with TRM82.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="9"/>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PB86"/>
    <dbReference type="STRING" id="1429867.A0A0G4PB86"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine(46)-N7)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03055">
        <property type="entry name" value="tRNA_methyltr_TrmB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025763">
        <property type="entry name" value="Trm8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="3-DEOXY-D-MANNO-OCTULOSONIC-ACID TRANSFERASE/TRNA GUANINE-N 7 - -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417:SF16">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 9 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 9" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="141"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="141"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="121"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="199"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="311"/>
            <end position="313"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL23582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="339" mass="38340" checksum="7819B026A218C07D" modified="2015-09-16" version="1">MATQNPPAKRVKREEYRRKVQAQQESTDGSVIKMPQKKFFRQRAHANPFSDHRLEYPISPAHMDWSSHYPAFVDPDTSKTNLSGGRKLTKEVEVVDIGCGFGGLMVGLAPLLPDTLMVGMEIRTSVLEYLSSRIHALRSQQQRLKNKAANPSSTEPQDASTQPENTESTPAPAPANDDEIGTDKLFPGNFENITAIRSNTMKFLPNFFGHHQLSKIFICFPDPHFKARKHKARIISESLNSEYAFVLRPGGLLYTITDVEEYHHWVLRHFLHGEQPEGGPAPAASSKDLFERVSEEELALDPCVRVMKFETEESKKVTRNKGNKYVAVFRRKADPEWPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBB7</accession>
    <name>A0A0G4PBB7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc finger, C2H2-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S010g000023</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PBB7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="79"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL23585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="313" mass="34767" checksum="0E902ACDB1A4EB0D" modified="2015-09-16" version="1">MATSWLQLSKSDFVNPDVLNAVNPHPRWGYAHGPIPDNNPDWKCKRDKYGQVSSSEQARTRTIRRPEAPMVTLNRYNIFVCDISTRGAPMCGMNFDAKFSLIRHIRAFHAGAANLPPSLYVTTGEKIAGNNAMKRWVLMGGWRDALYLNEPSRKNVSISLLGYYCDVLEGIARTDAQFAAEYGTEFHRPGHREWLESRDPGTYLPPDQPMPLTLPSIAPRNKSGKPSRCKRSTRTERVSDNDTDANPAFTSGSASAVSAPDREIVSKSASEVDSEPEDQEEWPVDAVTDIFAGLYLPSSKLDAAYGPISKQMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBB9</accession>
    <name>A0A0G4PBB9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Saccharopine dehydrogenase / Homospermidine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S010g000061</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PBB9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PBB9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004753">
        <property type="term" value="F:saccharopine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000072">
        <property type="entry name" value="Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF22">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="4">
        <location>
            <begin position="11"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase-like C-terminal" evidence="5">
        <location>
            <begin position="128"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL23623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="188" mass="19684" checksum="538239463A3C8E39" modified="2015-09-16" version="1">MVKQIAGSKALLLGSGFVTKPTVEVLSKADVEVTVACRTLESAQALASGFKNAKAISLDVNDDAALDAALNQADVVISLIPYTFHATVIKSAIRTKTNVVTTSYVSPAMMELDEQCREAGITVMNEIGLDPGLDHLYAVKTIHEVHAAGGKVTGFVSFCGGLPAPECSNNPLGYKVSETQPRCASCSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBH0</accession>
    <name>A0A0G4PBH0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Carbonic anhydrase</fullName>
            <ecNumber evidence="2 8">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S010g000111</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="2 8"/>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PBH0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PBH0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071244">
        <property type="term" value="P:cellular response to carbon dioxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00883">
        <property type="entry name" value="beta_CA_cladeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015892">
        <property type="entry name" value="Carbonic_anhydrase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002:SF76">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00705">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL23673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="211" mass="23202" checksum="F1C434EC23D54228" modified="2015-09-16" version="1">MSEDRYAAGLRLNKEWAAQTARKYPDLFPTLATGQTPQILWIGCSDSRCPETTFLGLEPGDVFVHRNIANVLHPGDLSSSGVIEYAVQYLRVTHVVVCGHTSCGGVAAAMGNKNLGILDPWLFPLRQLRERNLKLLQSLPSNEAGSKLAELNVREGLNIVKQKSVVLNAIRERGLQLHGLIYDVGSGVLSELDTQDSEEVIRARLTAFHTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBH7</accession>
    <name>A0A0G4PBH7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S010g000083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PBH7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL23645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="351" mass="39354" checksum="108621BBA90A336F" modified="2015-09-16" version="1">MQTDMSRKFIFLVGSPLAANLDWNTDELLNKPIPPFYENTESPEQELSLDQPPVRWRVLRSPSVDKLGDNYDSSQRYEDPAFFISHQLAVAADAPAEGHSEDSIHKFYDHSFAIHETSEVAGSDVYVADSTQESSLGEDSMLASFTGLDKSDTPRSPRILHIPGPLSNLQDLPTARYIQSIAPQTMTVNMIVGVLAVHPPRRIVTRQWKTELDLVELVVGDETRAGFGVNFWLKPDKPTAAKNNESDRLGRSLASLRPRDIVLLRTVGLSTFQDRVYGQSLRRGMTTVELLHRQPVDVTDAVGFYQGRMQEGSSQDDQPVLKARRVRNWMLRFVTDSVGMSHPRGLPPDTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBJ9</accession>
    <name>A0A0G4PBJ9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">7TM GPCR, rhodopsin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S010g000103</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PBJ9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PBJ9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000059">
        <property type="entry name" value="N-ethylmaleimide reductase, FMN-linked"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF93">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="4">
        <location>
            <begin position="13"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL23665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="408" mass="45533" checksum="7F14727CC1FE65B4" modified="2015-09-16" version="1">MTVHYLNGKDSGLFKPLTISNGNITLEHRVVHAPLTRNRGEPLNPSSTPDHPNRIWIPGDAVVEYYSQRATKGGLIISEGIPPSLESNGMPGVPGLFNSEQAAGWKRVVNAVHAKGGIIFCQLWHAGRATIPQMTGSPAVCPSASVWDSPTECYSHPPVGSTQSVPYANHPPVEMTVEHIKQTIDDYCTAAKTAMDIGFDGVEIHGGNGYLPEQFLSSNINKRVDAYGGTPEKRCQFVFELMEQVAKTIGEQNVAIRLSPFGMFNQARGEQRIETWTHLCEGLKKTLPSLSYVSFIEPRYEQIFGAEEKDKFLESWGLLDVTLDRFRQIFGSTPFFSAGGWDDQNSWGVVESGKYDALLYGRYFTSNPDLVHRLKEKIPMAPYDRTRFYGPFEDNTFHYTDYPTVDQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-11-27" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBL2</accession>
    <name>A0A0G4PBL2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid transporter, transmembrane</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S010g000145</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PBL2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PBL2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF668">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="51"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL23707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="456" mass="49620" checksum="B5FA61958995DA90" modified="2015-09-16" version="1">MEVNTAPPAYEQDKIAERKDVPQFEEEGQLKAGEVHDAFGNEEYAEIKYKTLKWWQCGLLMICESVSLGVLSLPAAVATLGLVPGVILIIGLGALATYTGYNIGLFRERYPHIQNLGDAGEILLGKFGRELFGTGQFLFCIFVMGSHILTFRVMMNTLTSHGTCSIVFSVVGMVISIALSIPRTMKGMTWISFASFLSISCAVVITMISVGVESHPGRVIHATVETNLYTAFQAVSNIVFAYCAHVAFFGLIAEMETPQDFKKSLFMLQGFEISLYLTAAVVIYFYVGSDVHSPALTSAGPLMSKVAYGIAIPTIVGAGVVNGHIGLKYIYFRLCSKSDLMHQRNKRSVGLWIGLGVACWVVAWIISEAIPVFSDLNGLISALFASWFSYGLSGIYWLHLNRGAWFSTPRKIFLTILNVGIACFGLALCVLGLYASGTAINKNSNSNSFTCANTDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBQ7</accession>
    <name>A0A0G4PBQ7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S010g000142</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PBQ7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PBQ7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF50">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="157"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL23704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="911" mass="102454" checksum="DFC42744386BEBFA" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PD06</accession>
    <name>A0A0G4PD06_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="15">AMP-dependent synthetase/ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S011g000199</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PD06"/>
    <dbReference type="STRING" id="1429867.A0A0G4PD06"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002145">
        <property type="entry name" value="ABC transporter (MsbA subfamily)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF330">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0436">Ligase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="544"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="700"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="245"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="515"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="786"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CRL24205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1003" mass="108971" checksum="D765AD5C694C00E7" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PD13</accession>
    <name>A0A0G4PD13_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mediator of RNA polymerase II transcription subunit 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S011g000210</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Mediator complex subunit 21 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PD13"/>
    <dbReference type="STRING" id="1429867.A0A0G4PD13"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.10">
        <property type="entry name" value="Mediator complex, subunit Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021384">
        <property type="entry name" value="Mediator_Med21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381:SF0">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381">
        <property type="entry name" value="RNA POLYMERASE II HOLOENZYME COMPONENT SRB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11221">
        <property type="entry name" value="Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="74"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="145"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL24216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="199" mass="21023" checksum="B208329A989EFCF9" modified="2015-09-16" version="1">MADILTQLQTCLDQLATQFYATLGYLITYHDNAPTTPPPNIPDAAPALAKITKNSSSPPVPAAIANKVGGAAAVAGNASPPHAPPQQPGAAPGTAVDGEDPNLPPAPDSPSTFASRQRELARDLIIKEQQIEYLISVLPGIGASEAEQETRIRELETELRGVEKERAAKVRELKKLRTRLEDVLGAVAVGIHGDGYPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDZ9</accession>
    <name>A0A0G4PDZ9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S012g000136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PDZ9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PDZ9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025633">
        <property type="entry name" value="DUF4291"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38567">
        <property type="entry name" value="DUF4291 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38567:SF1">
        <property type="entry name" value="DUF4291 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14124">
        <property type="entry name" value="DUF4291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL24527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="199" mass="22997" checksum="598A2D60D3E7BDC5" modified="2015-09-16" version="1">MASNTYRAIRAKQTPSTITVYQAYSPEIAEPALKAQKFVPPFSRERMTWIKPSFLWMAYRSGWATKSRQERVLAIEITREGFEWALRHSCLSHYTPGEETSQEEWRKKLRASPVRVQWDPERDISMRSLSYRSIQIGLSGEAVGRYIDQWIISVTDVTATMRLIDGYLKIGDVQAAKGCLPEETPFALPEDLQEYLKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PF45</accession>
    <name>A0A0G4PF45_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S013g000196</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit APL3 and beta-type subunit APL1), a medium chain (mu-type subunit APM4) and a small adaptin (sigma-type subunit APS2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL24953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PF45"/>
    <dbReference type="STRING" id="1429867.A0A0G4PF45"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14833">
        <property type="entry name" value="AP2_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000011">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027156">
        <property type="entry name" value="APS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0168">Coated pit</keyword>
    <keyword evidence="6" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="13">
        <location>
            <begin position="3"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CRL24953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="145" mass="17132" checksum="B6169B650CD4F809" modified="2015-09-16" version="1">MVLSFILVQNRQGKTRLAKWYSPYSDEEKVKLKGEVHRLVAPRDQKYQSNFVEFRRSTKVVYRRYAGLFFCVCVDANDNELAYLEAIHFFVEVLDQFFGNVCELDLVFNFYKVYAILDEVFLAGEIQETSKQVVLTRLEHLDKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PF85</accession>
    <name>A0A0G4PF85_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S013g000226</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL24983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PF85"/>
    <dbReference type="STRING" id="1429867.A0A0G4PF85"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000113">
        <property type="entry name" value="Cytochrome P450 monooxygenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF85">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL24983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="515" mass="58764" checksum="9D0929E5D16FB566" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PFM0</accession>
    <name>A0A0G4PFM0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamate-5-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="2">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S014g000002</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-glutamate 5-semialdehyde + phosphate + NADP(+) = L-glutamyl 5-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="2"/>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PFM0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PFM0"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000006">
        <property type="entry name" value="Gamma-glutamyl phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001221">
        <property type="entry name" value="PRK00197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063:SF8">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063">
        <property type="entry name" value="GLUTAMATE SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="12">
        <location>
            <begin position="6"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL25106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="456" mass="48559" checksum="602C61709D87CE5F" modified="2015-09-16" version="1">MPLTESAAVDAAQSASLASRRLATLNNDDRNKALTLLHDALEMNEKEILEANARDVELATIAAESGNLSHSVLKRLDLSRPGKYKDMLDGILSVRDLDDPIGKVTLRTLLDDGLTLERVSCPIGVLLIIFEARPEVIANIAALAIKSGNAAILKGGKESMESFAAIANVVSKAIAESRVPVASIQLVKTRDAVSSLLAQDSLIDLVIPRGSNELVRFVKENTKIPVLGHADGLCSAYIHADADIDTAVKVIVDSKTDYPAACNSLESLLVHQDTLESVFPAVAAALLEKGVTLRCDPDSKSALTKTLPAEKSAQVQTATESDYNTEFLDLVLAVKTIPSTDPPTTAVEAAIAHINVHSSKHTELILTQSKEAADMFMSGIDSAGVFWNASTRFADGMRFGFGTEVGISTNKIHSRGPVGLEGLTIYKYLIRGNGHGAADYGEGGKKYLHTNLPIGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PG15</accession>
    <name>A0A0G4PG15_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S014g000147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PG15"/>
    <dbReference type="STRING" id="1429867.A0A0G4PG15"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL25251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="211" mass="23610" checksum="9F34E19DD64A8A1B" modified="2015-09-16" version="1">MAEPVQSLLFCKHCEIYGHDVVHCHRPFEDLGNFATNNVIATGHPTKGLLQFILIMPDESKGKSFLGVSAKLSALPKESLLERQKAEAEAKRVREKAETPAVYEEFVKSFEDEDSVVPQSLDGGSNAFRGRGDDLPRPSKYGSLTTTSRFLPDGSGTSAAQSTNLTPIEAQALANYLEQHRQHWLWSRHVEHQWRYAGLFPIKPGRHNDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGY9</accession>
    <name>A0A0G4PGY9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S015g000098</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Lacoste S."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:intracellular polyamine homeostasis"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
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        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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            <end position="464"/>
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            <end position="492"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
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        <location>
            <begin position="24"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="507" mass="56296" checksum="7E8037FE548B4847" modified="2015-09-16" version="1">MSLNNQNSTPESPVALNTMQSPRIAEETPECERTVSPKELTKDDTKAELGSKQDIDPRGSEHVRRGFLPFLCFVPALQDPRHYTPGMKWVLTFIVAMGGLVVPLSSGVLFPCLIEIAEDMHTTVSVVNLSIAFGSLSVAIMPLWWSYLAEIYGRRLPNIGMFVAMRLLGSASSASLQAVSAGTISDMFEKQDRGKAMGAFMLGPMLGPMFAPIIGGALTMHWSWRSTQWFMVIYGWAVFLMMVLFMPETATNLEENRREHQNDATSPGKKPLHFLLKPMEAAKLLQYPPILITVYYTSIVFATYYLICVSIEDTFARPPYSWSSIIVGVAYIPGGLGLLFGAIIGGRWQDYIMVRTARKEGRYDDKGELILHPVDRLGENCLLAGILFPGALLWWGWTADKHEFWLVPLLGNFFYGFGGMILTNVTMTMLTEFTPKNSTIGVAVNNLVRNSLSCVSAVIAQPLFDAIGTGWSFTAVCLFCLLSGVPLILLRIKRDEWSRQMKATLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PI63</accession>
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            <fullName evidence="2">polynucleotide adenylyltransferase</fullName>
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        </recommendedName>
    </protein>
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    </gene>
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Nucleotidyltransferase"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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            <begin position="255"/>
            <end position="394"/>
        </location>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL26077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="710" mass="79659" checksum="A24B231192FCD60E" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PIM3</accession>
    <name>A0A0G4PIM3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S017g000016</name>
    </gene>
    <organism evidence="4 5">
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793150">
        <property type="protein sequence ID" value="CRL26033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PIM3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PIM3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42069">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-8 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42069:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="402"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="450"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL26033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="507" mass="55965" checksum="D8F4ECA2E06A8675" modified="2015-09-16" version="1">MAVSDDSRDNSPVTYEPVVPTDLTRASYHSAMGPPPQHTVRETRSGSDTSNASLKSPRTARFAEATSIHSPIDGTEAGRSPFSDPPKTQARGDVGDVGFGYVGANNEHADDQVPMSPFRPDLKVPQTAKSLNPLSPTFREEYLLEKQEKKAEVENARDLRIKLRVRIAKVFLRFVNFGCSLIVLSLLAVTLTVFNATKHLPTRNSLPAWAEGTNPWAQYLLLGMACVSLFACLIVFWAYRKGGHGRAEKTAVYYTGFSIAFFAVNLIMWIVGAAVYQHSKATGDSKDMWGWSCAQNTREQLYHNSVDYALLCRLQDWGLVCAIIEVVIEILVILIYVVVFYRVWSKRKLMKSMDTRDNARSDLYLAQLRLQSAPNTPGFAGFASYPPKSPFYAAGPVDPYSAAEKGMAQPQTTQYASPRSPTRPTPSFQLQPPPIKVQQPTPQTAQEEFAPPPPPSHYPQSPPPHGQHQSPPMNRGSAPGERTYDSVPIPGAYQSPMVPAFPAPVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJ07</accession>
    <name>A0A0G4PJ07_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATPase, AAA+ type, core</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S018g000065</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJ07"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJ07"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000549">
        <property type="entry name" value="ABC transporter ATP-binding protein arb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000618">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF15">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="77"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="388"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL26372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="609" mass="67973" checksum="17DA9EC17C803945" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJK8</accession>
    <name>A0A0G4PJK8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-adenosyl-L-methionine dependent methyltransferase, predicted</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S018g000237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJK8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJK8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010286">
        <property type="entry name" value="METTL16/RlmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393:SF0">
        <property type="entry name" value="RNA N6-ADENOSINE-METHYLTRANSFERASE METTL16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05971">
        <property type="entry name" value="Methyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL26544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="433" mass="48666" checksum="FB5AAD43959084A2" modified="2015-09-16" version="1">MESARSLYKNDIDFAALALQSRDFAKYLNQTGQLDFTDPAAIRQLTTTLLQQDFHLKVEIPEDRLCPPVPNRLNYILWLQDLLDSTAGGLHEGYDRDRDVFGLDIGTGCIGIYPLLGCATRPRWNFVATDIDSNNIRTSRHNVALNNLESRIQIIHSDPTGPLFPLEKLGRQTLDFTMCNPPFYTSPDELKQSAEQKEQEPFSTCTGADVEMVTRGGEVAFVKQMIDESLQLRDRIQWYTSMLGKLSSINVLVETLIKHGVTNFAVTEFEQGSKTKRWAVAWSWGDRRPAMNIARGIPGCPKSLLPFPADYTFTLPPGTSIDASTATINAELSSLPWFWAWDQTRSSGTGYAAENVWSRFARRKMKLAGEEGAAKLKVIPAQVALGVRLQIRLVRGQKPDEKEVRVLVRWAQGTDTVLFESFCGMVKRKLESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJL0</accession>
    <name>A0A0G4PJL0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S019g000036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJL0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="54"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL26620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="292" mass="32922" checksum="944300528C153943" modified="2015-09-16" version="1">MANKPDIEALFKSEAYASSFKRGEMVTRPFAEMLVDQSKVAAESKANPDKPLVVFDNACGTGVISSSLNDKLDDAVKKVWKLTCGDISPAMIEYTTRRIQEEGWQNAETKIVDAQKPELASAQFSHVFTAFAYMALPESVKALDETVRMLQPGGTIAFSTWIEPGWIAIAREAIKRMPGNLPFFEPEKFMAAMTDGKWDSKPWIESQLEERGFQDIDVRPTTIKLTLTCPVFVEMTMLVLPMMMKSFWNEKQQEENKDKLRPALEKYLEDTYGNGTMETDWVAILSTARNSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJS7</accession>
    <name>A0A0G4PJS7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S019g000030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJS7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL26614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="34" mass="3499" checksum="937952B44F3B975C" modified="2015-09-16" version="1">MEPDQAAFPRLASSPLGCLSLSVTTQSGNVYSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PK06</accession>
    <name>A0A0G4PK06_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable alpha/beta-glucosidase agdC</fullName>
            <ecNumber evidence="5">3.2.1.20</ecNumber>
            <ecNumber evidence="6">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PCAMFM013_S019g000177</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Glucosidase involved in the degradation of cellulosic biomass. Has both alpha- and beta-glucosidase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="5"/>
    <dbReference type="EC" id="3.2.1.21" evidence="6"/>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PK06"/>
    <dbReference type="STRING" id="1429867.A0A0G4PK06"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF67">
        <property type="entry name" value="ALPHA_BETA-GLUCOSIDASE AGDC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 17" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="10 17 23" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 19" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195745" description="Probable alpha/beta-glucosidase agdC" evidence="19">
        <location>
            <begin position="23"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="21">
        <location>
            <begin position="111"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="20">
        <location>
            <begin position="264"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="22">
        <location>
            <begin position="701"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="469"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="449"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="486"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CRL26760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="902" mass="101627" checksum="9ABC330AD8598C0E" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKD3</accession>
    <name>A0A0G4PKD3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40/YVTN repeat-like-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S020g000014</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793153">
        <property type="protein sequence ID" value="CRL26855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKD3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PKD3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000561">
        <property type="entry name" value="Putative WD repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045159">
        <property type="entry name" value="DCAF7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19919">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="350"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="393"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="506"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="547"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="82"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="449"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="550"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL26855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="613" mass="65569" checksum="A6533585E1C27348" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKY6</accession>
    <name>A0A0G4PKY6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PCAMFM013_S020g000188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HG793153">
        <property type="protein sequence ID" value="CRL27029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKY6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PKY6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11059">
        <property type="entry name" value="CYP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF164">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00067">
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    </dbReference>
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        <property type="entry name" value="EP450I"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL27029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="470" mass="53475" checksum="3089915BBE177E40" modified="2015-09-16" version="1">MLSLWVGAIFLCGCIVIFGFLSPLSTIPGPWYTRFTSFWIKYQEFTANRRESVHRLHKIYGPVVRLSPNELSFTSLDAIKEIYASGGSGYDKTEYYDLFRQFKIKTMFSTLFKDEHSKRKRIFADRYAMTNIMKEKPMAVIHERAMTFVSKCVEAGQKSVDVYSLLHCYALDCVTHFMFSPGGLKSLNVAEDYEIMHELTYHQSLQKNLLEYYLPLLAPYFPKFLHARSSPKANKYVIDMAAQTNLDGHSLMEKLKRKESNLELMQAAAECKDHMAAGIDTTGDGLCFLMWELSQPQNLCFQDKLYKELTAAPPNAPLDSYVYLDAVIKEALRCAPPIPMSLPRYVPAGGREIDGFAVPGNTIVSCQPYSVHRVNDSVFPEPDRFNPDRWLVEEGAAERNRLFFSFATGGRGCTGKNLALVEMKMLLREVYSRYRTTVASDMTASMKLEDQIISSRPKGQSCKLDFADIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PLA6</accession>
    <name>A0A0G4PLA6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S020g000092</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="HG793153">
        <property type="protein sequence ID" value="CRL26933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PLA6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PLA6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000017">
        <property type="entry name" value="E3 ubiquitin-protein ligase UPL7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000015">
        <property type="entry name" value="IQ and HECT domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF2">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="863"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="700"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="705"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="1207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL26933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1239" mass="140314" checksum="DD29B0598352D2E3" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PLT8</accession>
    <name>A0A0G4PLT8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S022g000047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793155">
        <property type="protein sequence ID" value="CRL27367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PLT8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PLT8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056599">
        <property type="entry name" value="AAA_lid_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23232">
        <property type="entry name" value="AAA_lid_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase lid" evidence="1">
        <location>
            <begin position="47"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL27367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="122" mass="13817" checksum="E0DAA27D54DE6813" modified="2015-09-16" version="1">MTYSLTYASSPPGVGKIFTVEATSEYFKLPLYSLNVIFKIAKHFNAILLLDKADAFIKHDLRRLESLALNGREIKNIATIAYALAEADASQVSYKYLELAAESNKKFSKEFGRERPVDRMYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMQ5</accession>
    <name>A0A0G4PMQ5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">hydroxyacylglutathione hydrolase</fullName>
            <ecNumber evidence="5">3.1.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glyoxalase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S023g000097</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58896"/>
            <dbReference type="ChEBI" id="CHEBI:71261"/>
            <dbReference type="EC" id="3.1.2.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.6" evidence="5"/>
    <dbReference type="EMBL" id="HG793156">
        <property type="protein sequence ID" value="CRL27639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PMQ5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PMQ5"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00676"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004416">
        <property type="term" value="F:hydroxyacylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07723">
        <property type="entry name" value="hydroxyacylglutathione_hydrolase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035680">
        <property type="entry name" value="Clx_II_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032282">
        <property type="entry name" value="HAGH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935">
        <property type="entry name" value="BETA LACTAMASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935:SF94">
        <property type="entry name" value="TENZING NORGAY, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16123">
        <property type="entry name" value="HAGH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="10">
        <location>
            <begin position="36"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL27639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="253" mass="28212" checksum="49D4E7427C5344A3" modified="2015-09-16" version="1">MNFLRTQLFGTSSRLFKSQVRAMHIQSIPMWTGKGNNYAYLVTDESTKKSVIIDPANPPEVAPELKSQIASGKIDLTAIVNTHHHWDHAGGNNDILKQFKGLQVIGVKALHTPCHTQDSVCYYMQDGDQRVVFTGDTLFIGGCGRFFEGNAKEMHKALNETLAALPDDTKVYPGHEYTKANVKFCIAVSQSEPIKKLQAFAEKNKETQGKFTIGDEKLHNVFMRVNDPEIQKVTGKTDPVDVMAALREMKNAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMV1</accession>
    <name>A0A0G4PMV1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MARVEL-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S022g000146</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793155">
        <property type="protein sequence ID" value="CRL27466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PMV1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PMV1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G08640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608:SF2">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="13"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL27466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="173" mass="19228" checksum="D9074FDEAF6F139A" modified="2015-09-16" version="1">MGFFKHPCGAISTIAHIIQCISSLIVLGITAWAVRGTKTLTVIFSLVVAVLTPIIHGITLSTSCITRRRRWHVLPLLVTDAVISYLWLTAFIFLSLNFNHVSCSVHLWNRQTVCSRKYSAEAFSFIAFFATLMALAFEILYTYLPKNDTPVREKPNGVGHLEDNLRGAGVMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PN40</accession>
    <name>A0A0G4PN40_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Protein farnesyltransferase subunit beta</fullName>
            <shortName evidence="9">FTase-beta</shortName>
            <ecNumber evidence="2 9">2.5.1.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S024g000054</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-cysteinyl-[protein] + (2E,6E)-farnesyl diphosphate = S-(2E,6E)-farnesyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11535"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:86019"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="2 9"/>
    <dbReference type="EMBL" id="HG793157">
        <property type="protein sequence ID" value="CRL27799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PN40"/>
    <dbReference type="STRING" id="1429867.A0A0G4PN40"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02893">
        <property type="entry name" value="FTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000014">
        <property type="entry name" value="Protein farnesyltransferase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026872">
        <property type="entry name" value="FTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF6">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="11">
        <location>
            <begin position="105"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL27799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="490" mass="53436" checksum="56C6379957B836CA" modified="2015-09-16" version="1">MPLIGKPRKVRFPNAQKPTKNRPTATLTTKTTRTTMTTMATMNTSDSNQPRPGIPALFTQPPPIRDPLITETVDLQSTTLEKCLPFLKGIHSAQKDFNDHGVPALQRDLHAGFLYDALEDYPEGFVAMDASRPWIVYWALAGLAMLGEETTRFRERVITTLRPMQNPTGGFGGGHGQTSHLAGSYAAVLSLAMVGGEEAFGLVDRHAMWQWIGRLKQPDGGFRVCEGGEEDVRGAYCAMTLISLLDLPLTLAPGSQAREAGLESLTSGLPEYLSRCQTFEGGISGSPGSEAHGAYAFCALACLSILGPPEEIFNRHMDIPMLVSWLSARQSAPEGGLSGRTNKLVDGCYSHWVGGCWPLLESSLEGKPDNTQPPANSLFSREGLTRYILACCQGNDGGLRDKPGKHVDSYHTCYVMAGLSATQNHHYRTDSSIASNNFTSSFSWKSSPNRDPGNVFSRGDRLEPMHPLYVIPHKAAEQMRLWSEAQPLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPT5</accession>
    <name>A0A0G4PPT5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD40/YVTN repeat-like-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S027g000069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793160">
        <property type="protein sequence ID" value="CRL28380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PPT5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PPT5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF1">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195511" evidence="2">
        <location>
            <begin position="19"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL28380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="410" mass="43258" checksum="CAEFC65ACAEDF3EE" modified="2015-09-16" version="1">MHLQTLLPILSAIGTTSATIASKPAHLWATHYNGNVYSLTLKNNNLSLAQTLNTCGDMPSWLTLDAHTRTVYCSDESGTADASTHGSLTALHVKPDGTLREGAVAKTVGGGVNSVIYESDAGKKFIAIAHYEGSAISTFALPIKQNQPALQAFHFNLTRPGKVAQQDSPHPHEVFLDPTGSFILSPDLGADLLRVYAIQDGPSGKLSECPSLNITYGSGPRHGVFWTDGTDRSAGAGSTHSRKVAAVGETMLYLANEIGGTIMVFDVSYSRSGCLSFEKTQTLVPYPGGVMPEGATPAAISRIGNEFYVSIRTDQGFKPNDSIVVLDRSPVDGSLELRDSSSAFGKVPRTFVINQAGDLVAIGNQASATVAIVRRNPETGNLGEEVASLQVGEPGKVGTAEGLSSIIWDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQ32</accession>
    <name>A0A0G4PQ32_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S028g000013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793161">
        <property type="protein sequence ID" value="CRL28460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQ32"/>
    <dbReference type="STRING" id="1429867.A0A0G4PQ32"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48312">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48312:SF1">
        <property type="entry name" value="SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL28460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="402" mass="44711" checksum="DC4740A59927BB33" modified="2015-09-16" version="1">MSNKPIFVATHPRACSTAFERVFMTQRDTIQCVHEPFGDAFYYGPERLSSRFAGDEHAQARLDSGFANSTYSTVMERLERETTQGKRVFIKDIDHYLLPPNGQPASIAPSLLRVKRGVGTNGDSHKANGVNGANGTTHTNGHTNGVNGTSNGTNGTANGVNGHEMNGHTNGATNGHTNGTSKEPYPYDTPTEPGNPTVMPRELQEQFHWAFLIRDPHYSVPSYLRCTIPPLDEVTGFHNYDPLEAGYDELRRHFDYLRETGLVGPRVATRPELNASSDAETTTGVEVCVIDADDMLDEPAKTIEAFCNSTGLPYRPEMLTWDTEAEHAVARNAFEKWRGFHNDAIESKALVQRAHKRAVKTEEQFDAEWQKKYGEKQAALIRQTVDANMADYLYLKSFAVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQ53</accession>
    <name>A0A0G4PQ53_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein DML1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein dml1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S028g000043</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the partitioning of the mitochondrial organelle and mitochondrial DNA (mtDNA) inheritance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the misato family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793161">
        <property type="protein sequence ID" value="CRL28490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQ53"/>
    <dbReference type="STRING" id="1429867.A0A0G4PQ53"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06060">
        <property type="entry name" value="misato"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049942">
        <property type="entry name" value="DML1/Misato"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029209">
        <property type="entry name" value="DML1/Misato_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019605">
        <property type="entry name" value="Misato_II_tubulin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION REGULATOR MISATO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391:SF0">
        <property type="entry name" value="PROTEIN MISATO HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10644">
        <property type="entry name" value="Misat_Tub_SegII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14881">
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            <end position="303"/>
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        <source>
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        <source>
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            <dbReference type="Pfam" id="PF14881"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="CRL28490.1"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="498" mass="56770" checksum="1613D153FAFC58FA" modified="2015-09-16" version="1">MHEIVTLQLGQRANYLATHFWNLQESYFTYNDGEQSDVDHDVHFRPGVGADGSETYTPRTVIYDLKGGFGTLRRYNALYELSEDSTAGQGLWDGREIVQKQTPIQQSEYQKSLDLGTTAPRLTSESVRYWSDYNRVYYHPRSIVQLNEYDLNSQTMPFEDWNVGEDLFKDLDKEHDLLDRDLRPLLEECDHLRALQLFSGSDDAWGGFAAQYMERLRDEFGKKSIWMWAIEDGTRTQRHHQFKKDTNKARSLCSISPLASLYSPIIDVPHNLPGYLNVDRQSEWQKTALLASAIETVTLPSRLRPYQHFEASLAGEDGTHTIFELQSSINKIKINDGQTKEASNEDGPPKAEIEFEIDFAYDGEYSKGAHIFNQVQVTRGEEPERDSESTEDTDVGYLRKLRRYNSELMLQSFHTPLSMPILDSFPHDMFPTPETGTGVNVFTALTASTRTAQKIKAISATAGRLVSVDEREALVNGLGEIREYYETGWSSGSDDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQ75</accession>
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            <fullName evidence="6">Translation initiation factor eIF2B subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
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        </alternativeName>
    </protein>
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        <name evidence="11" type="ORF">PCAMFM013_S028g000073</name>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
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            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
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        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="CRL28520.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="545" mass="59739" checksum="8DD332A6764F5119" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQC3</accession>
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        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">PCAMFM013_S027g000025</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">FM 013</strain>
        </source>
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    <dbReference type="EMBL" id="HG793160">
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="FNIP_N_dom"/>
    </dbReference>
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        <property type="entry name" value="RE13835P"/>
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        <property type="entry name" value="RE13835P"/>
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    </dbReference>
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        <property type="entry name" value="FNIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Folliculin-interacting protein N-terminal" evidence="2">
        <location>
            <begin position="85"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        <location>
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        </location>
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        <location>
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        </location>
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        <location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Pfam" id="PF14636"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL28336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1207" mass="130218" checksum="A1CD497DC2D03470" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQT7</accession>
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        <submittedName>
            <fullName evidence="4">Str. FM013</fullName>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 25 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793163">
        <property type="protein sequence ID" value="CRL28764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQT7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PQT7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06532">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050757">
        <property type="entry name" value="Collagen_mod_GT25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002654">
        <property type="entry name" value="Glyco_trans_25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730:SF53">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730">
        <property type="entry name" value="PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL28764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="384" mass="42826" checksum="C6891E6749CF3F0A" modified="2015-09-16" version="1">MIARRNVLQVAVAAALTAYILCTLLVRNFGDISWSPSLPDLSRNYMADSVFEHIQNNTLGFEHIYAISMKERTDKRDFLTLAASVSGFKVEWLDGVRPDDLHPKAMPDGLNPLLVKPTVVACWRAHMNALVNVISNGYSTALILEDDADWDVNLKSQLGEFARGLHSLKGTKFVSQEAPYGIDWDLLWIGGCASGPNANETSFYAIPMDPTVPRSHHRATWGGPTNQWKQQYPELAEDSTRFIYRAEMGCCMFGYAVTTKGARKIVSALSIDHLDKPVDDALSELCAGASGRHKIECWAPFPNLIGTYRKAGSASRDSDIESNNAAEFHEELAWNMVYSTRRNIQQLVAGGETVYSQWKDEDVPWSSKAIKHREFAYPTGYLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRL0</accession>
    <name>A0A0G4PRL0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polynucleotidyl transferase, ribonuclease H fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S030g000090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793163">
        <property type="protein sequence ID" value="CRL28803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PRL0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PRL0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF25">
        <property type="entry name" value="RNASE H TYPE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNase H type-1" evidence="3">
        <location>
            <begin position="51"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL28803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="376" mass="41450" checksum="3D16BCB0B1546203" modified="2015-09-16" version="1">MADPPAGALEATPTNTQETTNPFSLEEFQPSIIEVGSDRETAIEQAEAIRSTSDIIVYSDASGRDGQSGAAVVTFNDDMEMVESQQVQVGPMDRWSVHVAELIGIFYAISTVFKMAHRQPRPEDRQATATILCDSKSALQAIKSVRNKSGQRIVHAIHQAATEVQTAGTALRLQWVPGHCDNPGNDAADRMAKLAASPGKSHPFRPLLTRERAFIRRNITSQWEHEWRTSSKGGHLRKIDDTLPATYTRKLYGSLPRGRAYLLTQLRTGHNWLSTYRKKIGYSEDDRCDCGAQETVTHVLVDCPSLVELRRNLRREVGNAFNSVSSLLGGSKQGEKGKPDTVSRAKKAQAVLDFAEASQRFRSRAPRGQPNNGNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRR2</accession>
    <name>A0A0G4PRR2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S033g000030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793166">
        <property type="protein sequence ID" value="CRL29110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PRR2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PRR2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000063">
        <property type="entry name" value="MFS multidrug transporter, putative (AFU_orthologue AFUA_2G05840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF7">
        <property type="entry name" value="DRUG_PROTON ANTIPORTER YHK8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="495"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="526"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="560"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="129"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="739"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="743"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL29110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="770" mass="86049" checksum="0F990197D6808436" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PSH3</accession>
    <name>A0A0G4PSH3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        </location>
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            <end position="156"/>
        </location>
    </feature>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
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</entry>
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        </source>
    </evidence>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Conseiller E."/>
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            <dbReference type="PubMed" id="24407037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="175" mass="20021" checksum="88AA02226C68E763" modified="2015-09-16" version="1">MSSTWSSQRSMQLLLLLFTFLSITSLVAASTPTSFCKCTCFSNSTIIPLNPAKSETSSGIDHVLRFYERDSLSSEIEHTDEYIKRAQKYRSLSCNDCNRKFCLDYELPTCKGAKEEDVYTTCFQRDSRKDEAVVFIFIFATGGLLAWAACKPWIERYVEAARERRSYIPVAEPDR</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
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        <location>
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            <end position="529"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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    </feature>
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            <end position="419"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL29561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="695" mass="78804" checksum="9B550DA17BC02F2E" modified="2015-09-16" version="1"> </sequence>
</entry>
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    <accession>A0A0G4PTU3</accession>
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        </submittedName>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="201"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL29566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <sequence length="218" mass="23756" checksum="894136A1D9B547CB" modified="2015-09-16" version="1">MHILVLGASGAIGRLFCDIALNEGHRLTLFVRNASKIPEHIRLSERAEIIVGTLEADSDLEEAAKCGADIFISFAGPAFGAQGTPLTDAYKVLIPKLASQNITRILILCTPSFRDESDVITSMWWAGKWFMKLFSSGQYQEMVGVGEAISSLSDTDGLRWGLFRVGGLTNGKEAPVNATYLGSGVDNTWISRASVARWVLDEAIEGKWVGKMPYICNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793174">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005605">
        <property type="entry name" value="Spo7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28249">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN SPO7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28249:SF1">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN SPO7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03907">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
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        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
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            <end position="52"/>
        </location>
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        </location>
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            <end position="40"/>
        </location>
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            <end position="352"/>
        </location>
    </feature>
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            <end position="376"/>
        </location>
    </feature>
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        <location>
            <begin position="384"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL29935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="463" mass="52573" checksum="399EB4A76F0AB642" modified="2015-09-16" version="1">MASPLDQMVKGAPTPDARASTTPEPLNSSRSSQAPRSDPSPQRPSTPDPLAHLPSSPPQIYLNLLILETSLRAQYLALRERRRQNTFFLLLLAAWLAHFAYALFLRPREDGRGVGGSVYWVVEMAEKVALLGGVVTALLVWGTGQWERGIRWPRRWLAVSNRGLRVMNTKIIIIRGPFWQELLSYISFLFPFSAPFLPSPNGNYHFVEQSPSDKRAGGSRQHYQQYYNGTDTESGLVEEDLSPGGDYIRLLLLPKSFSPEFRENWDDYRTDFWEKENERRAQLRLKLREREHHLAQTEGGWLNRLGFGWRASQRRRLVAGTLHRPIEPEFKHRLGHGHHPSITKLNQEQRGPSSRRNTRSESHSRTSSRSTTPVDTSFEDRPPSRSSTSSRPRRGSTASGQDASPQQRKRKGSTLRRGLSPLTQAQIREGVRTPSFSSDDSVLPMGMIEKDKEEAIPNSVPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PTZ4</accession>
    <name>A0A0G4PTZ4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S038g000036</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793171">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PTZ4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:phosphoric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956:SF1">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195839" evidence="3">
        <location>
            <begin position="23"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="452"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="452"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL29633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="634" mass="70752" checksum="A17B70125630BFC4" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PU07</accession>
    <name>A0A0G4PU07_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S038g000039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793171">
        <property type="protein sequence ID" value="CRL29636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PU07"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL29636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="136" mass="15370" checksum="53793F29E5626915" modified="2015-09-16" version="1">MTKSTSDIFMSIKPEHVQNIASGSKNHEYRSYLLPSTIRHIWFYTTSPIKRIEYVARISSGKVPGEVPDDGGIGNAEFNTGLSESKYGYEILTLWRLKTPVSLEEALVEGFLKSAPQKYCRVSFDFLGRFLLDGQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUE0</accession>
    <name>A0A0G4PUE0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2423 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S044g000056</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793177">
        <property type="protein sequence ID" value="CRL30125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PUE0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019434">
        <property type="entry name" value="DUF2423"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28219">
        <property type="entry name" value="UPF0642 PROTEIN YBL028C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28219:SF1">
        <property type="entry name" value="UPF0642 PROTEIN YBL028C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10338">
        <property type="entry name" value="YBL028C_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2423" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL30125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="117" mass="13084" checksum="B8FC22C4EE27C1A9" modified="2015-09-16" version="1">MAKSVRASVSKRNRANLRKKVFGPLVDARTERLAAKLQELASQPRPEAPVKSKMDLAEDEAAEAAKAQTGDSEEMDIDTIKSSKKKQARVQKRNQKPRNSIVFQKRLSTAKKGPKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUW7</accession>
    <name>A0A0G4PUW7_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 5B</fullName>
            <ecNumber evidence="3">3.6.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Translation initiation factor IF-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCAMFM013_S041g000071</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="3"/>
    <dbReference type="EMBL" id="HG793174">
        <property type="protein sequence ID" value="CRL29929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PUW7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PUW7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03703">
        <property type="entry name" value="aeIF5B_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000013">
        <property type="entry name" value="eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000026">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000112">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029459">
        <property type="entry name" value="EFTU-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003078">
        <property type="entry name" value="PRK04004.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14578">
        <property type="entry name" value="GTP_EFTU_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="15">
        <location>
            <begin position="452"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="107"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="235"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="357"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CRL29929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1045" mass="115528" checksum="634682053EACD880" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PV88</accession>
    <name>A0A0G4PV88_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Haloacid dehydrogenase/epoxide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S050g000037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793183">
        <property type="protein sequence ID" value="CRL30390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1429867.A0A0G4PV88"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
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        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
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        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01493">
        <property type="entry name" value="HAD-SF-IA-v2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF9">
        <property type="entry name" value="ACID DEHALOGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="237" mass="26733" checksum="04AA4A54C25E4DDB" modified="2015-09-16" version="1">MTQLSDYRLLSFDVYGTLVDWEGGILAAFQPTLDKTGAQFSREHLLTVYHELEREQQSKTPDMPYHQLLTTVHPKFAKRLGLEIPSQEESNQFGESVGSWPAFPDTVDALKRLSKHFKLVVLSNVDRASFAKTNAGSLEGFPFDLIITAQDVGSYKPDLQNFEYMLSVVKSKFNIEPSQVLQTAQSQFHDHHPASKIGIKSAWIERPGATMGNLPDNIYDWRFDTMGDMAKAYEAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PW77</accession>
    <name>A0A0G4PW77_PENC3</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">PCAMFM013_S056g000022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PW77"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022198">
        <property type="entry name" value="DUF3723"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12520">
        <property type="entry name" value="DUF3723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL30649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="846" mass="96729" checksum="63F9B75C5188E60D" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PWU0</accession>
    <name>A0A0G4PWU0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S060g000035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793193">
        <property type="protein sequence ID" value="CRL30825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PWU0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL30825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="71" mass="7844" checksum="0A03902726222B7B" modified="2015-09-16" version="1">MSLPYLGTPIGPNDGVGKVNGRVMTKEVNQRTKRHAITRRYSGISRDALIIEMQNNTGQAVISRTFTLISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PWX8</accession>
    <name>A0A0G4PWX8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S056g000041</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793189">
        <property type="protein sequence ID" value="CRL30668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PWX8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="9"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL30668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="487" mass="54705" checksum="C21C31DACB56E793" modified="2015-09-16" version="1">MSSPAPKRACDQCHTLKEKCRRPSAITPCERCDRLNQTCKTTRDLAKLGRKPRIARKLSYNLPTSNFSSVTCNTKKLELSSPENNNHYPHFYLSFDEGLSSNPALFPELDQWERHFLNLMKDLGAPSPLDKFLIGPSFHESHHRFFVQNLLRPASTSILKDATVACAAVLLGDQCAQYTKTSVELGHRRAALAVSGLRSLQISKEQDLVTALVLGVSIVTFAMHVVDGQPFLISHYTLALIKPVYHTLLKMDPSIMDLLMCLVNTETFECLIRSEMPTIRIGEYDRCDVVDRYIGISSSLYSHLYDLCEASYLMRLAGGRMDFEMVERLDAIQDSLERWTPSPPPDFIERFTQSEVVGMFAQAKVLRLAALLIAHRLRHPYGQRDKEALQLSSAITAGIDMALQSTGRSIPCTTLPYTVAGFEIAGTEARAVVVDKIPEAVTFSRQAQLQVRRSLSSVWNARDGGDQIYWFDLGNYIHKIPSTWTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PX26</accession>
    <name>A0A0G4PX26_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S064g000004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793197">
        <property type="protein sequence ID" value="CRL30930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PX26"/>
    <dbReference type="STRING" id="1429867.A0A0G4PX26"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="581" mass="65801" checksum="492A909A583027F6" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PXC1</accession>
    <name>A0A0G4PXC1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Amino acid transporter, transmembrane</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S068g000016</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793201">
        <property type="protein sequence ID" value="CRL31030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PXC1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PXC1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005290">
        <property type="term" value="F:L-histidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015189">
        <property type="term" value="F:L-lysine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015194">
        <property type="term" value="F:L-serine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF678">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="11">
        <location>
            <begin position="33"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="422"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL31030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="502" mass="54069" checksum="BE89B197A7440163" modified="2015-09-16" version="1">MEEAALGVGLSGGHQNAMRRRAARGRPGDVVGEASWASSVINLVNTIIGAGVLAMPLAISRMGIVLGVCVILWSAATAGFGLYLQSLCAQYLDRGSASFFALSQLTYPNAAVVFDCAIAIKCFGVGVSYLIIIGDLMPGVVQGFVGSEPGYDFLVDRHFWVTAFMLIVIPISYLRRLDSLKYTSIAALVSMAYLVVLVVYKFVQGDTMEDRGPIRVGHWEGAVPTLSSLPVIVFAFTCHQNMFSILNEIGNNSHFRTTAVVFASAGSAAATYILVAITGYLSFGNSVGGNIVGMYPPGVYATIGRAAIVMLVVFSYPLQCHPCRASVDAVLKWRPRPQVTGAERSPNRHPLLGPRGNRTPEPMSDLRFSVITTTILILSYLVAMTVSSLESVLAYVGSTGSTSISFILPGLFYYKISSPDSPTHRGLMKEDDEAEDYLSEDDEGDDGEGSLARSLTESGLLPRGTRHWRKALLRPLSLALALYGFLVMIVCLVTNTFFKTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PXN7</accession>
    <name>A0A0G4PXN7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S064g000005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793197">
        <property type="protein sequence ID" value="CRL30931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PXN7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL30931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="74" mass="7946" checksum="F83E0A515C456780" modified="2015-09-16" version="1">MKFDDNTDCETIVLPGIPPGIEFVKGRITCMGEKHLSPEWSTMCLKNNKLAVIMLSNISQGPSLQVGKGVAAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PXU2</accession>
    <name>A0A0G4PXU2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S066g000015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PXU2"/>
    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL30986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="229" mass="26773" checksum="9D613469837BA81F" modified="2015-09-16" version="1">MMVRPQRGVTCVRNKRTGHDLSLDVVTLPESFSDKVPFRAQHLVLQAVQKILEQSGFRFVQHLLPQECHSFDWECAESMELHKLFPFLDQHKEKICFQGFRQILIKLHRMRGMVTSIRHAAVHRIVQDRKSFLGMLQTAVAFTRCIGDDKCTQQLGCLCISLDTFLAKLNERSNHLQERIRFQISLCQSRPKELMQRRVLLPNAIKKVTEQSEQTFNLQVQEFVRKNLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PYP8</accession>
    <name>A0A0G4PYP8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S4Jg000033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793313">
        <property type="protein sequence ID" value="CRL31511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PYP8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL31511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="179" mass="19456" checksum="AFDBCBE4AB572A2E" modified="2015-09-16" version="1">MDKAILGLTAQEIREVFTICGIEDSEEHLNLVIAHAADHVYKARLVIAGGATEPISQAKEAIIETPSTPPHETRGSYRLMKQTGKDVPTTYSDMASTEKKKKKKRKRSDKSELIDQPPGASVADGTGTAKDKAPEESISPEIQTTSEVDDPESSCVPNPRDSSLPLHLDSAFEMKVITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PZ32</accession>
    <name>A0A0G4PZ32_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger, RING-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S3Jg000043</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793312">
        <property type="protein sequence ID" value="CRL31432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PZ32"/>
    <dbReference type="STRING" id="1429867.A0A0G4PZ32"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07199">
        <property type="entry name" value="Pat17_PNPLA8_PNPLA9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF8">
        <property type="entry name" value="PNPLA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="402"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="8">
        <location>
            <begin position="467"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="6">
        <location>
            <begin position="471"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="6">
        <location>
            <begin position="503"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="6">
        <location>
            <begin position="665"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="505"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL31432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="939" mass="105156" checksum="3A0145168632A2E0" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NTS5</accession>
    <name>A0A0G4NTS5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Glucose-6-phosphate 1-epimerase</fullName>
            <ecNumber evidence="3 5">5.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S001g000319</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the interconversion between the alpha and beta anomers from at least three hexose 6-phosphate sugars (Glc6P, Gal6P, and Man6P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:16249"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58247"/>
            <dbReference type="EC" id="5.1.3.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glucose-6-phosphate 1-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.15" evidence="3 5"/>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NTS5"/>
    <dbReference type="STRING" id="1429867.A0A0G4NTS5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047938">
        <property type="term" value="F:glucose-6-phosphate 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09020">
        <property type="entry name" value="D-hex-6-P-epi_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025532">
        <property type="entry name" value="G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122">
        <property type="entry name" value="APOSPORY-ASSOCIATED PROTEIN C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122:SF13">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016020">
        <property type="entry name" value="PHexose_mutarotase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR016020-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016020-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL17359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="319" mass="34808" checksum="87E7B3D8B3AE0F03" modified="2015-09-16" version="1">MDRSNKPSAIGVGASLPQPTLSIKDNIIEASLPTGQSVTVHLYGATVTSWETGGQEQLFISEKSHLDGSKPIRGGIPLVFPVFGPPPQNHATSTLPQHGFARNSNWEFLGKSSSEAPGRDSDQTDLTVKLDFGLSHSMLTDEFRAAWPYEFGLVYSVTLTTDSLETALQVRNEGQQNFDFQVLMHTYLSIADISDIRVKGLESKTYIDKTLQATSHTESSPALAITQETDRIYQQLDPAVPIVVASAKDDQSLFSITREGLTDVVVWNPWIEKAKGMADFGPDEAYKNMICVEAGSVSGWQTLEAGEAWEGGQSIKSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NU15</accession>
    <name>A0A0G4NU15_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S001g000527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NU15"/>
    <dbReference type="STRING" id="1429867.A0A0G4NU15"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL17567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="183" mass="20657" checksum="B5AFE22F6FA54DCD" modified="2015-09-16" version="1">MKDLRAHYLLEGDDKPPIPPLYTCNSKHTSGYPCIHIIKEYEDEHKYLEPELFHQHWHLHRISAPPINPILLLQEPLQVRRRGRPRGARNFISQSTTQQAIQESTQDILSSPDPLTQDRSTRREPSAFEHVLSQEGGRGRGRRRGRGRGTSSGETASAEPTSTEEQGRGRGRGRGGKRARGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NUS6</accession>
    <name>A0A0G4NUS6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCAMFM013_S001g000719</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NUS6"/>
    <dbReference type="STRING" id="1429867.A0A0G4NUS6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000023">
        <property type="entry name" value="Putative ferric-chelate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF24">
        <property type="entry name" value="REDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005194798" description="ferric-chelate reductase (NADPH)" evidence="14">
        <location>
            <begin position="17"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="318"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CRL17759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="597" mass="66956" checksum="6BD664FDE833CEE4" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NV03</accession>
    <name>A0A0G4NV03_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S001g000847</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NV03"/>
    <dbReference type="STRING" id="1429867.A0A0G4NV03"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37919:SF2">
        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37919">
        <property type="entry name" value="PROTEIN CBG05606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL17887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="244" mass="27140" checksum="6884D412FF92AC94" modified="2015-09-16" version="1">MVSTRHHPREFPSPEAGKELAKSPPATTSANSRKWTHTPAAALTIWLIASVPLVIWDTGYVLLRPHSMPGGRLHSPIWTPYALYGKVDYIYGWPAFNAHNGFTAAQTILNILETIGYIYYLWIVYHYGSTVGRGGSQKISKGFTWLLKGDKVVAGRIGATALLVAYTASVMTLSKTVLYWLNEVFSGFENIGHNEPLTLFLCWILPNGMWLVFPSYNIYILGGEILNSLELATPRQKVGRPKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWP4</accession>
    <name>A0A0G4NWP4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily, general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S002g000345</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWP4"/>
    <dbReference type="STRING" id="1429867.A0A0G4NWP4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="483"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="507"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="94"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="637"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="653"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL18475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="664" mass="75291" checksum="776A3940FDC3923A" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWW1</accession>
    <name>A0A0G4NWW1_PENC3</name>
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        <submittedName>
            <fullName evidence="6">Ras small GTPase, Rab type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S002g000279</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18409.1"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RAB"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
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        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
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        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
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        <location>
            <begin position="126"/>
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        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL18409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="182" mass="20018" checksum="BB9C082DE629128D" modified="2015-09-16" version="1">MGGSLSRIWSLLWSKKEIRILILGLDNAGKTTLLYRLKIGEVVTTIPTIGFNVESVTYKNLNLNVWDLGGQTSIRPYWRCYYANTAAVVFVIDSTDIERLGTAADELAAMLNEEELHDAALLVFANKQDQPGAKGAGEISEALKLGELRDRNWSIVACSAIDGKGINEGMDWLVQTIQSENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXK7</accession>
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        <recommendedName>
            <fullName evidence="5">RAD52 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S002g000681</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RAD52 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4NXK7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045002">
        <property type="term" value="P:double-strand break repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.80:FF:000001">
        <property type="entry name" value="DNA repair protein RAD52 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.80">
        <property type="entry name" value="DNA repair protein Rad52/59/22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004585">
        <property type="entry name" value="DNA_recomb/repair_Rad52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041247">
        <property type="entry name" value="Rad52_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007232">
        <property type="entry name" value="Rad52_Rad59_Rad22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042525">
        <property type="entry name" value="Rad52_Rad59_Rad22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00607">
        <property type="entry name" value="rad52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132">
        <property type="entry name" value="DNA REPAIR AND RECOMBINATION PROTEIN RAD52, RAD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04098">
        <property type="entry name" value="Rad52_Rad22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="219"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="293"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="410"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="510"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="532"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00077224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL18811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="608" mass="64846" checksum="85BD4113EBCE54C1" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYA9</accession>
    <name>A0A0G4NYA9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">2-oxoglutarate reductase</fullName>
            <ecNumber evidence="4">1.1.1.399</ecNumber>
            <ecNumber evidence="5">1.1.1.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCAMFM013_S002g000916</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.399"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.399" evidence="4"/>
    <dbReference type="EC" id="1.1.1.95" evidence="5"/>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL19046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NYA9"/>
    <dbReference type="STRING" id="1429867.A0A0G4NYA9"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061759">
        <property type="term" value="F:2-oxoglutarate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12176">
        <property type="entry name" value="PGDH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000036">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000041">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050857">
        <property type="entry name" value="D-2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008759">
        <property type="entry name" value="PRK11790.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="15">
        <location>
            <begin position="393"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CRL19046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="463" mass="50632" checksum="576920B53DF027BF" modified="2015-09-16" version="1">MSIARDIRPRQDDAAFLATSPSASFNSPSSHSSVLNRTIPLNAKPLKPFATEDIKVLLLENVNQTGREILSQQGYQVEFLKSSLSEDQLIEKIRDVHVIGIRSKTKLTARVLKEAKNLIVIGCFCIGTNQVDLQYAADQGIAVFNSPFSNSRSVAELVIGEMVMLARQLGDRSNEMHAGTWNKVSNGCWEIRGKTIGIIGYGHIGAQLSVLAEAMGMSVIYYDVLNIMSLGTARQVKTLDDLLAEADFITCHVPEIPETKGMIGQKQFEKMKKGSYLINASRGTVVDIPALIDAMRSGKVAGAALDVYPNEPAGNGDYFNNDLNTFSADLRSLKNLIITPHIGGSTEEAQKAIGVEVAQALVRYANEGSTLGAVNLPEVVLRSLTMDEPDHARVIYIHKNIPGVLRKVNEIIGDHNVDKQMTDSRGDVAYLMADISNVDAATIKDLYTRLESLPSRIMTRVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZG4</accession>
    <name>A0A0G4NZG4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger, C2H2-type/integrase, DNA-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S003g000190</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZG4"/>
    <dbReference type="STRING" id="1429867.A0A0G4NZG4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000201">
        <property type="entry name" value="C2H2 finger domain protein (Gli3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000031">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056436">
        <property type="entry name" value="Znf-C2H2_ZIC1-5/GLI1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23561">
        <property type="entry name" value="zf-C2H2_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="144"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="177"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL19399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="392" mass="43658" checksum="F14DC145F48E2E71" modified="2015-09-16" version="1">MASRDSPGSPLSSVGSLETSDHESMKHESRAHSPSMSNLPPSKRRRTGVASWDRQTPLSSAQDDIHPPPSPTASISSDSSGDIPNSPSILSLLGTNQEEDYSGQSTDQVTICRWDGCSAGDLGNMDGLVQHLHNEHIGSRQKRYSCEWNDCTRKGQTHASAYALRAHMRSHTREKPFYCTLPECDRNFTRSDALTKHMRSVHETDTMRPIDSISKVHGTPGSTTGTPASKLQRIRLKLTQPREPGTESEPHTEAITIVPHPVTTDTHDSEETSMPEFGPELDFDEPELALPPRELYRLLRRQIAWAGKEATQLQAEWETIRPQRERAWREKEAIFDDLIDAEIGLFSAMVGSVPPAHLTTSLEKLQKQQQQFQDQQDQLVKSAEVPTVEGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZK8</accession>
    <name>A0A0G4NZK8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S003g000284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZK8"/>
    <dbReference type="STRING" id="1429867.A0A0G4NZK8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL19493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="202" mass="23421" checksum="35C0E27A097F740B" modified="2015-09-16" version="1">MLLSSGIFEPFSFPCMQLRQCMCAQWWREYVNKPPHKLPLEDIHRGLRDMDLWKGMVWSNKVPNDEAESLAYTSQRLVCSAIVQEYHVMIQEGLEYSYLTTEDSPRPSPNEDLQSPSRAIARVLCLCLISFCSQLRNQEWRNEYCRDLEVWTTQFDGLYETVCSRELQQNPHSDNTDYVSPISPATSPEFLESSPIPSMLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0M3</accession>
    <name>A0A0G4P0M3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S003g000621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P0M3"/>
    <dbReference type="STRING" id="1429867.A0A0G4P0M3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL19829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="107" mass="12070" checksum="D6FC97D833AC80F5" modified="2015-09-16" version="1">MKHGRPWTATMSNDSATVISSPECREGSSNETRSTNQRTGSQRASLAAEAIYVFLSQHFLHWVEAMSLMRMAPEIVGVIDTLHSLIEEHSPLILFLRDARRFVQILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P1I7</accession>
    <name>A0A0G4P1I7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-glycosylation protein EOS1, transmembrane region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S004g000126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P1I7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021100">
        <property type="entry name" value="N-glycosylation_EOS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28147">
        <property type="entry name" value="N-GLYCOSYLATION PROTEIN EOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28147:SF1">
        <property type="entry name" value="N-GLYCOSYLATION PROTEIN EOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12326">
        <property type="entry name" value="EOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL20186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="338" mass="37684" checksum="18B4516E18ED3C71" modified="2015-09-16" version="1">MNESPSYRDYSLYLPRLLAPQRNASPPPYTRHDYPPQHPPRGPDLNLARSALPPSYLNTSPEILQSQLAKEVASPSASTIPPSPTSSTSHTPLSSDGPPSALHPRVAVILGVDRRWYIPLLVCRALSTLPAGWWGLRCAFTFLAELLHIRPGMGREGWAAAIVGSVGQEWDVERRFRVTEVALAIMWCCASAYLSYFFADCMMSRWLLNYTPPAVVIRLLTTNGLIAYITSWVLYLSGASSDPRLLLPAWISITTSLTFVYHATQNHATIKRETAASLLVVSVASFLSMSSLLMQLHLTRENEPEVPVFVITRKLWDWAVAIFLRMRVSDDRIPIGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P218</accession>
    <name>A0A0G4P218_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S004g000289</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Clathrin-coated vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P218"/>
    <dbReference type="STRING" id="1429867.A0A0G4P218"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016482">
        <property type="term" value="P:cytosolic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14831">
        <property type="entry name" value="AP1_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000007">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044733">
        <property type="entry name" value="AP1_sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="10">
        <location>
            <begin position="3"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL20349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="156" mass="18336" checksum="34937F5C365D5238" modified="2015-09-16" version="1">MPVHYLILLSRQGKVRLAKWFTTLSPKEKAKIIKDVTQLVLSRRTRMCNFLEYKDSKVVYRRYASLFFIAGCASTDNELITLEVVHRYVEQMDKYYGNVCELDIIFNFQKAYFILDELLIAGEMQETSKKNVLRCISQQDSLEDMEVEEDVVTKIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2C5</accession>
    <name>A0A0G4P2C5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutamine synthetase/guanido kinase, catalytic domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S004g000338</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P2C5"/>
    <dbReference type="STRING" id="1429867.A0A0G4P2C5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785">
        <property type="entry name" value="GAMMA-GLUTAMYLPUTRESCINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785:SF2">
        <property type="entry name" value="TYPE-1 GLUTAMINE SYNTHETASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GS catalytic" evidence="4">
        <location>
            <begin position="118"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL20398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="442" mass="49468" checksum="A638B119C63DA532" modified="2015-09-16" version="1">MAKTTALTQWQQFHAKNPDVNFVWVFFTTYIGTNLVRIVPMPEFKRLLETDQGISVPKVILHVLPYDNVAEGGTLTGSFFLKPDPRCLSPYMDKNKAIVMSSWTDKEKLPMGECARSKVDTLTRLIEQKSNCSILVGFELEFCLLRQRTLDNGKVEYETVNTDHSWCSMTREDELLLGILEEAVLALHNVGIMVQQFHAELGPGQWEFVLPPDIPLRAVDALVLARQVVMKVANKHGYRATLHPRLSPEQPGTGAHVHISLNSEEVHLPTVESFFAGILEHFTSISAFTLPQEISYGRVVGGIGSGGDYVCWGWENRETILRQISSNRFEIKMMDGLANPYLALCSLLAAGLDGLLQGSFLSAGPCTIEPSKMSDQERAALGIKTMPGELTQSLKNLEANERLKQILSDSMVSTYLTVKRSELKVMQQMTPEESRAWFISKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2L7</accession>
    <name>A0A0G4P2L7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc finger, C2H2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S004g000512</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P2L7"/>
    <dbReference type="STRING" id="1429867.A0A0G4P2L7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="199"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL20571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="227" mass="25243" checksum="8647F20668383F8A" modified="2015-09-16" version="1">MAWSPYNVPPNASGTPGQDQGAGDAYHPYGSAAHQYPPSLATEPLMFPENHLPYNTPMQHPSAPVNPNYNVPFLMIRTDFDSPNHNAVHNPSIENYRPRELSPMGYLSSGPSTPCTTPSGSGSSTPAMQEMPQSSIGGHEMQTIYGAAQTLRPGHNELHGAYECNWQCNWENCKHRGPFSRKGVLMRHIETQHVAPHSIKCLVCGRMFSRRDNMTEHMGRVHSQRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3F7</accession>
    <name>A0A0G4P3F7_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosome subunit biogenesis protein NIP7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S004g000774</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with pre-ribosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NIP7 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P3F7"/>
    <dbReference type="STRING" id="1429867.A0A0G4P3F7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21146">
        <property type="entry name" value="Nip7_N_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21151">
        <property type="entry name" value="PUA_Nip7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.10:FF:000002">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.220:FF:000001">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040598">
        <property type="entry name" value="NIP7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055359">
        <property type="entry name" value="Nip7_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016686">
        <property type="entry name" value="Ribosomal_synth_fac_NIP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005155">
        <property type="entry name" value="UPF0113_PUA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17833">
        <property type="entry name" value="pre-PUA_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03657">
        <property type="entry name" value="UPF0113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017190">
        <property type="entry name" value="Rbsml_synth_fac_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88802">
        <property type="entry name" value="Pre-PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUA" evidence="8">
        <location>
            <begin position="97"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL20832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="184" mass="20240" checksum="D6B8FF5E9CEC3E2B" modified="2015-09-16" version="1">MRSLTEEETRTLFTKLASYTGRSLNSLITPAEDGTMSVFRLQGSRVYYVNKEIANLSVSFPRETLLSCGTMVGKFTKTGKFRINLTALDLLAQHARYKVWIKANGVMPLLYGGSVLKAHVARFSEDVPENAGVVIMDSNDVPLGFGVTARSSAQIAKLDPTSIAVHRQADAGEYLREEDTLFTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3M3</accession>
    <name>A0A0G4P3M3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hly-III related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S005g000061</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL20897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P3M3"/>
    <dbReference type="STRING" id="1429867.A0A0G4P3M3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF130">
        <property type="entry name" value="HAEMOLYSIN-III FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="11"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL20897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="313" mass="35326" checksum="CE8A6BDCD8A77BF1" modified="2015-09-16" version="1">MALLKRLSAVERASGTDRGDSPLLKEPGSPSGPRLLNRDEVPSWYGHNPYIRTSYRPVTPSISRCLSSLLYLHNETVNVYSHLIPATIALLGNGLLYVYFSASFPDATWADQLVFHIYLTTSVICFGISSAYHTFLCHSARYTDLWGRLDYVAIVFQILGSFISGIYIGFYCEPHLQKLYWSMIGSLGFLTGFVVVHPKLQSQKWRLLRLSTFVATGLSAFAPIIHAASIFPYKQLDQQAGLRYYYLEGLVIVIGVLFYATHFPESRRPGSFDIWGSSHQVFHISVVIGAMVHLYGILVAFHWNYEHQRCKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3R5</accession>
    <name>A0A0G4P3R5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S005g000145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL20981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P3R5"/>
    <dbReference type="STRING" id="1429867.A0A0G4P3R5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.200">
        <property type="entry name" value="LURP1-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007612">
        <property type="entry name" value="LOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038595">
        <property type="entry name" value="LOR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31087">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31087:SF161">
        <property type="entry name" value="TUBBY C 2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04525">
        <property type="entry name" value="LOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL20981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="202" mass="22128" checksum="CDD0BC0175696503" modified="2015-09-16" version="1">MGILGHHNLDPVAEPIAIFDQYVAKEPQTIVLKEKVLSVSGDSFDIKLANGEPFLKVQGAWVSFSGRKKVEDAHGKHLFDIVKELLHIRSTYAIEDTHRKKICEVKSSLTLIGSKAVASFTDSHGKAVTLKMKGGWFDHTADIVDEKSGQTVARIDRKLLSGRDLVFGQQTYAVVVAPGVDAALIAALCICFDEKNNEERGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P428</accession>
    <name>A0A0G4P428_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S005g000187</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P428"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL21023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="349" mass="38694" checksum="72792F526AF68287" modified="2015-09-16" version="1">MPVDRSKQVTLRRSCQACIKGKRRCDQGWPRCSRCLGKDISCEYANAPLTIQSTRKPSSGRNVGPNRSIVNATPTPQIHAPLQLEIAKEYEPNIIQFLVAGLRDLPVNFAETRKTLFIHPDLYPNGLPTPVREVHNICRHNMQTAQTGRVSVTLLSMLRQYSADLCRRLSHAATFEELLAYSQALVLIQCMLVLNEDGNACPYSEAISGMLAGIAGKLWQQAPIQLPQTLSPRCAWLLAESVRRTIIVCFMLRSAYSLNTRNYTVRTPFIDSLPFDLRTNLWDENSETAWQDALSDSEGSMVSLNEWSNGLAAGRVHDVSCFSGLILAACKGQAVSSIPSPPVNSYIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P4F6</accession>
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            <fullName evidence="3">Str. FM013</fullName>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P4F6"/>
    <dbReference type="STRING" id="1429867.A0A0G4P4F6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054505">
        <property type="entry name" value="Myb_DNA-bind_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22980">
        <property type="entry name" value="Myb_DNA-bind_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like DNA-binding" evidence="2">
        <location>
            <begin position="27"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL21200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="115" mass="13024" checksum="C3EAA3373AC90742" modified="2015-09-16" version="1">MAPNKPASKAGKSPAKPKEPRDSDLKKQLLFLWACHKVSDVQIDIPAVAKYFGIKNNAAQMRFKRMKKKLDEMEVSAKSDEETHASKSKDDDYKVQAMELTYEATTEDERDAMSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P4L1</accession>
    <name>A0A0G4P4L1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxidase</fullName>
            <ecNumber evidence="8">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S005g000382</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="8"/>
    <dbReference type="EMBL" id="HG793138">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P4L1"/>
    <dbReference type="STRING" id="1429867.A0A0G4P4L1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00691">
        <property type="entry name" value="ascorbate_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000009">
        <property type="entry name" value="Ascorbate peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000005">
        <property type="entry name" value="Cytochrome c peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002207">
        <property type="entry name" value="Peroxidase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF36">
        <property type="entry name" value="L-ASCORBATE PEROXIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00459">
        <property type="entry name" value="ASPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 8 11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="10">
        <location>
            <begin position="13"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL21218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="304" mass="33497" checksum="DC7D6D4F0C7D18D6" modified="2015-09-16" version="1">MSTHDYDAVRKDIADILKKPGYDDGSAGPVFVRLAWHSSGTYDAESDTGGSNGAGMRYEAEGGDPANAGLQHGRAFLEPIKEKHPWITYSDLWTLAGVVAIKEMGGPDIPWKGGRTDLIGETKLPPRGRLPDGAQGADHLRFIFYRMGFNDQEIVALTGGHNLGRCHGDRSGFEGPWVTNPTRFSNSFFKLLLQLDWKPRKMASGNTQFVYEDPDAEEDEEPLMMLPTDMALSTDPVFAPWVKRYAEDKELFFDHFSKVFAKLVELGIRRDAQGTVTNTDGTLGGYVSAPKKSNTATGPPRARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P500</accession>
    <name>A0A0G4P500_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S005g000542</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P500"/>
    <dbReference type="STRING" id="1429867.A0A0G4P500"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL21378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="78" mass="8581" checksum="1582D5B304AB3BD1" modified="2015-09-16" version="1">MHSHSPVCQERPPKISYGSVGASKSSPPPAKHSSKSASYHRKANSSSAHFYFAVAYFYILFTLSGKQAEGTIMQYILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5X1</accession>
    <name>A0A0G4P5X1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S006g000265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P5X1"/>
    <dbReference type="STRING" id="1429867.A0A0G4P5X1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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</entry>
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    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL21907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="247" mass="28620" checksum="EF603D8C988B264E" modified="2015-09-16" version="1">MAALWENNGQPGQFPLEQWFYEMPPVTRWWTVATVATSVLVQCHIVTPFQLFYSFRSVYVKSQYWRLLTTFLYFGPLNLDLLFHVFFLQRYSRLLEETSGRSPAYFAWLIFYAMTSLLIISPFLSIPFLGSALSSSLVYIWARRNPDTRLSLLGLLVFTAPYLPWVLMGFSVIVHKIVPKDEMLGVVVGHIWYFFNDVYPPLHDGHRPFDPPRWWVRLFEPAPSPSERTTGAAVNREFAAAAAPEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7G8</accession>
    <name>A0A0G4P7G8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S007g000195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P7G8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195309" evidence="2">
        <location>
            <begin position="17"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL22214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="196" mass="20002" checksum="D3EA14ABB53D5115" modified="2015-09-16" version="1">MLFFITLVYFQACVLAAGSAASHDISNPVSITITTTGTATRYTTVIALETTSSARHLHSSLANPKGTNRLTRTRTMRPQGASPSSTDLLRHSPIGSVEAAHHPTIRGSRFPTSTPVSTPATPSIPTPISPTSSSPGSTSSPGSTSSPGSTSSPGLTSLPGSTSSSTTSNGTESVQVPLRTTLIIGLGCIFAVFGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P824</accession>
    <name>A0A0G4P824_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Crotonase, core</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S007g000423</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P824"/>
    <dbReference type="STRING" id="1429867.A0A0G4P824"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051750">
        <property type="term" value="F:delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000004">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000024">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045002">
        <property type="entry name" value="Ech1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149:SF1">
        <property type="entry name" value="DELTA(3,5)-DELTA(2,4)-DIENOYL-COA ISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL22442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="281" mass="30664" checksum="A10AF4F85C8F244D" modified="2015-09-16" version="1">MADNYSFEYFTIQLPTDHQYVAHVEINRPERLNAFIEVMWENMAQIFNKLSSDPRVRAIVLSGAGEKAFTTGLDVKAASEGLLSSDAKADPARKAAVLRRHITAFQDCITAVERCEKPVIVALHGFSLGLGIDLSTATDVRLCSRNTRFGVKEVDIGLAADIGTLSRLPKVVGNYGWVKEVALTAREFGAEEALRVGFVNAVYDTREATIAAAFKLASLIASKSPVAVQGTKEILNFSRDHSVQDGLRYTSVWNSAALQTQDVSAALLSGLQKRTPTFEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P865</accession>
    <name>A0A0G4P865_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Multi antimicrobial extrusion protein MatE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S007g000509</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P865"/>
    <dbReference type="STRING" id="1429867.A0A0G4P865"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        <source>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <end position="469"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.</text>
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        </subcellularLocation>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Rnh202_N"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNase_H2-Ydr279"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ydr279_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="34"/>
            <end position="125"/>
        </location>
    </feature>
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        <location>
            <begin position="128"/>
            <end position="327"/>
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    </feature>
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            <end position="23"/>
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        </source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="429" mass="47795" checksum="568A3426C8FE2DF5" modified="2015-09-16" version="1">MRTRSAPVSKSKKAEDETKTKTLVAAEKPSKTFILPSSTSDNARLLSLPDPQSGELTRYFFCPDRGIYEFTVVAPPAHMARSILFTPRTRETPSPLEEEKKDPEEPSVQGSITKKAEFLVATPIDTMFFMVPLLAPSSKSGRSLFQPLDDIIDSQDDMPKNLRQVLYDDKFRGFLLARTEAICEVVEAGDEKMFRFNETKLVQELITKAERMADRGLPVSLEERFVRQTLATPLMSVKREDVATSQEPSNESQESASKSEERQNSPSTVDTTATPSVATPAGESTPVPQPPSAESTATDPITRLLRISTALSFMKESYLPATMASRLDEILASADSPIDFKPLKDRLKEISDLRAQALASRDMSNFSRKRALDDEEDDTRAEKKRRKEEEEKKSKAAESQAVKNLKKVNTSGMQKMSAFFAKAPPKKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PA41</accession>
    <name>A0A0G4PA41_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine-protein kinase 33</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793142">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PA41"/>
    <dbReference type="STRING" id="1429867.A0A0G4PA41"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL23183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="179" mass="21246" checksum="79E9849F98547B59" modified="2015-09-16" version="1">MRKKKVYEVIGYKSRSSLVLRPPEARFEPKKPLSFLSDIWTLACTIWSIIAQRTLFEGFLATEDDITCEHVDTLGILPPEWWKRWEARQNKFTEDGRPINRAYNYFRSWDDRVEDSVEQPRRKKGVPSFDAKERDAIFNMLRPMLSFRPEDRPTTKQILESEWMVKSALPEYGKIQNNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAQ5</accession>
    <name>A0A0G4PAQ5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cystinosin/ERS1p repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S009g000342</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PAQ5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PAQ5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015184">
        <property type="term" value="F:L-cystine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005282">
        <property type="entry name" value="LC_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131:SF5">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL23402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="272" mass="30838" checksum="DF41335E8E6E70A7" modified="2015-09-16" version="1">MMNATWTESISQTLGWAYFILWSLSFYPQVLYNHRRRSTDGFSIDFALLNVLGLSAYTVSNACFLFSPVVRAQYAQRHPQSPEPTVQWNDFVYALHGALICCWICSHFLCTRFWNFESKPQRPSTLALVVFWGCLGVVPLPILCVLVSASWEWIDVVYVVGMIKVVLTAVKYTPQAVMNYRRQSTEGFSIVAILLDLSGAILSLTQLVLDSSMQGDWSGAVGNIAKLLLGNITVLFDLIFIFQHFAVYREQFAENKPRLSERDPLLDSRNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAX9</accession>
    <name>A0A0G4PAX9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase, class 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S009g000411</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PAX9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PAX9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002918">
        <property type="entry name" value="Lipase_EstA/Esterase_EstB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32015">
        <property type="entry name" value="FASTING INDUCED LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32015:SF1">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195180" evidence="1">
        <location>
            <begin position="20"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="32"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL23471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="278" mass="29782" checksum="401186002D5D2763" modified="2015-09-16" version="1">MPSFIKLALSALAATTAVATGINDFSCKSSYNPVVLLHGLGATFYEDLNYMQYWLQAQGFCTYARTYGAYDGFPLLGGLKAINESAPEIAAYIKEIVEKTGKSKVDLVGHSEGAFQSLYVPKFEGVSHLIDKIASIAPPTHATTFAGIYNLAYQFGNESRAAVGEVLDTLGCPACNDLGPDGPAIKRLNDGTPIAQPGNSITIIASKYDELVTPPSTSFVHEEGVTNRWIQDTCPLDPVGHIGEAYDLNVWHLVRNVLTSTPDKKFLCLLGSPVSSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAY5</accession>
    <name>A0A0G4PAY5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Beta-ketoacyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PCAMFM013_S009g000422</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4PAY5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000019">
        <property type="entry name" value="Polyketide synthase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="27"/>
            <end position="454"/>
        </location>
    </feature>
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        <location>
            <begin position="989"/>
            <end position="1302"/>
        </location>
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        <location>
            <begin position="2478"/>
            <end position="2559"/>
        </location>
    </feature>
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        <location>
            <begin position="2579"/>
            <end position="2609"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="12">
        <location>
            <begin position="989"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="12">
        <location>
            <begin position="1138"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2619"/>
            <end position="2667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2891"/>
            <end position="2911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="2624"/>
            <end position="2634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="2647"/>
            <end position="2667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="2892"/>
            <end position="2911"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="12">
        <location>
            <position position="1021"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="12">
        <location>
            <position position="1209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
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    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CRL23482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="2985" mass="328657" checksum="3D19FD05E7764B9C" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PC21</accession>
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        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
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        <name evidence="1" type="ORF">PCAMFM013_S010g000294</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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        <property type="entry name" value="Peptidase_S1_PA"/>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL23856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="637" mass="70805" checksum="A60B425D236E1643" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCN4</accession>
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        <submittedName>
            <fullName evidence="2">Dimeric alpha-beta barrel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S011g000051</name>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
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    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24057.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="ABM_dom"/>
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    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40624">
        <property type="entry name" value="BIOSYNTHESIS MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12025)-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR40624:SF1">
        <property type="entry name" value="BIOSYNTHESIS MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12025)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="5"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL24057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="107" mass="11947" checksum="AAD1A788023E53CC" modified="2015-09-16" version="1">MSEVINQIAILTAKPGKLDELVAELANVTRNVQEHEPETTVYYAYSIADKNEVIVVERYTNQAALDKHRAAPYFQELIKKAPALLAKPLELKTGSQLLQDSAQVVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PD66</accession>
    <name>A0A0G4PD66_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S011g000267</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4PD66"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000003">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.130.10">
        <property type="entry name" value="Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain (AZUL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032353">
        <property type="entry name" value="AZUL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042556">
        <property type="entry name" value="AZUL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF8">
        <property type="entry name" value="HECT-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16558">
        <property type="entry name" value="AZUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="929"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="150"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="247"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="587"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="284"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="419"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="1307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL24273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1339" mass="150437" checksum="7E88BF0C069BBABE" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDI4</accession>
    <name>A0A0G4PDI4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S011g000360</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PDI4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PDI4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.690:FF:000003">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000021">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.690">
        <property type="entry name" value="Importin-alpha, importin-beta-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036975">
        <property type="entry name" value="Importin-a_IBB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="10">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="7">
        <location>
            <begin position="125"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="7">
        <location>
            <begin position="167"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="7">
        <location>
            <begin position="336"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="529"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="541"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL24366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="552" mass="60463" checksum="9B285DF5BC7C7DD0" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PE41</accession>
    <name>A0A0G4PE41_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S012g000193</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CRL24583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF6">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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            <begin position="156"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="156"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL24583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="412" mass="45300" checksum="A78483EC3905CA99" modified="2015-09-16" version="1">MVEEPQTPSSKGFGAEIFKIFGGGGSGSAPSGNAPKKTTRDGQQPKRRGPKPDSKPALTRRQELNRQAQRTHRERKEQYMRALETEVSRLREAYTTEIAEANASIQQHKELMHSIREDNEILKEILVASGIQYEAELERRRAERPPMMPFQSSPLTVAGSSTASQSAPLAHSASNHNTTPATTISSGMSPRANGMDHSEISPAIGYASHQQVYHAGAGEHSMNMDHSSCAPVDTMQPMPVTRGGVFETDPQLQVDFILTLEGPCREHTDYLCRRSVTEADDEDMPFSGHALMATCPPPSYIAKTTHEQPYPHKAPDLPHANLSTLLNLSRQLVTEGQITPIMALQCLKNHELYPTLRRDDIKIIMDTLNTKVRCYGFGAVVEDFELIDCLSSVLGTKVDLGMSGTADDSMYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PEV2</accession>
    <name>A0A0G4PEV2_PENC3</name>
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        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL24849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="PINX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149:SF33">
        <property type="entry name" value="PROTEIN TMA23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL24849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="260" mass="28779" checksum="85CFA7A8CF15E14A" modified="2015-09-16" version="1">MDAQAYLIKHGWSGPGNPLNPNKRPGAHSGLGLTRPLLVSRKANNHGVGKKTTKDPTNQWWLRGFEDALKGVGNDSFEANSARENNALTSELYRHFVRGDGLAGTLEGNDKKKDESGTSTSTSKSKRKRENEDEGDRKARKLAKAARKVEKAERKEARRVKRAAKAERKEKKIAGKLAKKALKEKKRTASEEDYPTPTSIDQESDQTGAENTETDEVAARLEKAAKKEKKESKKAKSDGVAEDSKKKSKKEKKDKKEAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PEZ9</accession>
    <name>A0A0G4PEZ9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">tRNA(His) guanylyltransferase</fullName>
            <ecNumber evidence="3 14">2.7.7.79</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">tRNA-histidine guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PCAMFM013_S013g000093</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a 5'-end ribonucleotide-tRNA(His) + GTP + ATP + H2O = a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54564"/>
            <dbReference type="Rhea" id="RHEA-COMP:14193"/>
            <dbReference type="Rhea" id="RHEA-COMP:14917"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:141847"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.7.79"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="16">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the tRNA(His) guanylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.79" evidence="3 14"/>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL24850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PEZ9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PEZ9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008193">
        <property type="term" value="F:tRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3000:FF:000001">
        <property type="entry name" value="tRNA(His) guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025845">
        <property type="entry name" value="Thg1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024956">
        <property type="entry name" value="tRNAHis_GuaTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007537">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038469">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729:SF6">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04446">
        <property type="entry name" value="Thg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14413">
        <property type="entry name" value="Thg1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028980">
        <property type="entry name" value="tRNAHis_guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 14 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 14 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 14 20" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNAHis guanylyltransferase catalytic" evidence="18">
        <location>
            <begin position="6"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Thg1 C-terminal" evidence="19">
        <location>
            <begin position="141"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="223"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="29"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="75"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR028980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR028980-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR028980-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF14413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CRL24850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="287" mass="33523" checksum="60A7DCCC68C3F515" modified="2015-09-16" version="1">MANSRFEYVKSFEQPDVLLPNTWIVVRIDGRGFHKLSDHYAFAKPNDRRALDLMNAAAVEVMKELPDLCIAYGVSDEFSFVFHPNCQLFERRNGKLVTTIVSTFTAHYIYNWSEFFPERPLLPPYLPSFDGRAVIYPNNRILRDYMSWRQVDCHINNLYNTTFWTMVLQGGMSNTDAEQELKGTVSADKNEILFKRFGINYNNELEIYKKGTVLYRQYELEEPKPTKAPADEESPVIESQQSRSQQDKIRKLRRKAQVVIDHVDIIKDEFWEKRPWILSGNPGKLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PFA1</accession>
    <name>A0A0G4PFA1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Diphthine methyl ester synthase</fullName>
            <ecNumber evidence="4">2.1.1.314</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Diphthamide biosynthesis methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S013g000188</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 4 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="EC" id="2.1.1.314"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the diphthine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.314" evidence="4"/>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL24945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PFA1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PFA1"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141133">
        <property type="term" value="F:diphthine methyl ester synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11647">
        <property type="entry name" value="DHP5_DphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.950.10:FF:000004">
        <property type="entry name" value="Diphthine synthase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000004">
        <property type="entry name" value="Putative diphthine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01084">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00522">
        <property type="entry name" value="dph5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882:SF0">
        <property type="entry name" value="DIPHTHINE METHYL ESTER SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="DIPHTHINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036432">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="12">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="112"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036432-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL24945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="285" mass="31537" checksum="2EA6143994894A02" modified="2015-09-16" version="1">MLHLIGLGLADETDITVRGLEIVKRAERVYLEAYTSILLVDKEKLEAFYGRPVIEADRELVETGSDDILAGGDKADIVFLVVGDPFGATTHTDLVLRARELGIETKVVPNASIMSGIGCTGLQLYNFGQTVSMVFFTETWKPSSYYDRVRENVQIGLHTLVLLDIKVKEQSLENMARGRRIFEPPRYMTVAQCASQMLETEEERQEGVYGPDSLAVGAARVGAANQQLVSGTLKELATVEMGAPLHSLVLLGRRTHDLERDYIREYAVNKETFDASYVKGYGASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PFZ6</accession>
    <name>A0A0G4PFZ6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ankyrin repeat-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S014g000139</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PFZ6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PFZ6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="7">
        <location>
            <begin position="178"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="6">
        <location>
            <begin position="459"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="684"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="717"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="750"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="816"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="849"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="882"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="951"/>
            <end position="984"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL25243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1090" mass="121138" checksum="779876C48DC8CFA5" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGE3</accession>
    <name>A0A0G4PGE3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S014g000299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PGE3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL25403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="76" mass="7900" checksum="D14FC1201029B4BD" modified="2015-09-16" version="1">MIDLGGRVSRRSSSDKSLSGEVVRFKIEEGTFFPARGLTGEGNFGSGPTNISPCSSSSAISQPATVDHQLAEISSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGG5</accession>
    <name>A0A0G4PGG5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">F-actin-capping protein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S014g000307</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 10">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the F-actin capping complex, composed of a heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the F-actin-capping protein beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PGG5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PGG5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.570:FF:000001">
        <property type="entry name" value="F-actin-capping protein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.210:FF:000005">
        <property type="entry name" value="F-actin-capping protein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001698">
        <property type="entry name" value="CAPZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043175">
        <property type="entry name" value="CAPZB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019771">
        <property type="entry name" value="F-actin_capping_bsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA ISOFORMS 1 AND 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01115">
        <property type="entry name" value="F_actin_cap_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00192">
        <property type="entry name" value="FACTINCAPB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00231">
        <property type="entry name" value="F_ACTIN_CAPPING_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0117">Actin capping</keyword>
    <keyword evidence="6 10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL25411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="291" mass="32739" checksum="37C48DB14EE43B36" modified="2015-09-16" version="1">MHAPHPPKINTAIHQATGIQLTFATMADAQFDSALDLLRRLNPRDTKTNLQAITSIVPELTEDLLSSVDQPLEIRRCPQSNRDYLLCDYNRDGDSYRSPWSNEFDPPLEDGTVPSERVRKLEVAANESFDVYRELYYEGGVGSVYFWDLDDGFAGVILLKKGVTPGSQSSGEWDSIHVFEATDRARMSHYKLTSTVILHLANKTEALGDMDLSGNMTRQVEVDLPVESDASHVANVGRLVEDMELKMRNLLQEVYFGKAKDVVGELRSLGPLSDANRDRETQREMIMSMQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGV9</accession>
    <name>A0A0G4PGV9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor CWC2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Pre-mRNA-splicing factor cwc2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PCAMFM013_S015g000195</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the first step of pre-mRNA splicing. Required for cell growth and cell cycle control. Plays a role in the levels of the U1, U4, U5 and U6 snRNAs and the maintenance of the U4/U6 snRNA complex. May provide the link between the 'nineteen complex' NTC spliceosome protein complex and the spliceosome through the U6 snRNA. Associates predominantly with U6 snRNAs in assembled active spliceosomes. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM CWC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793148">
        <property type="protein sequence ID" value="CRL25609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PGV9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PGV9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12360">
        <property type="entry name" value="RRM_cwf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000249">
        <property type="entry name" value="Pre-mRNA-splicing factor CWC2, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034181">
        <property type="entry name" value="Cwc2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
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        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
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        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
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        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
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        <location>
            <begin position="184"/>
            <end position="258"/>
        </location>
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            <begin position="122"/>
            <end position="148"/>
        </location>
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            <begin position="1"/>
            <end position="23"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072313"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CRL25609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="403" mass="44549" checksum="CCBC7718BFA44397" modified="2015-09-16" version="1">MADTSFAEPPAPISTTAPETLEPNAEQMTVATTGAADETLQGDQQLQSVKKTKIIRRKKRPARIQVDPSTIKAEPAQQPGLDYNIWYNKSGDNDDKYGLSQPAPSRCNIARDSGYTRADRVPGSFFCIHFARGVCVKGQDCEYLHRLPTIHDMFNPNMDCFGRDKHSDYKEDMSGVGSFTRQNRTIYVGRITVSDDIEEVCSRHFAEWGQIERTRVLTGRGVAFVTYSSESNAQFALVAMQNQSLDHEEILNVRWATVDPNPMAQKREARRLEEQAAEAVRRALPAAFVAEIEGRDPEAKKRKKIEGTFGLQGYDVPDDVWHARTRQLEDASQAAQLEAPEQPMMIESAPVSAQEQQQPQSNGIFSSSAVAALHGLNGGRVTTQAPKATAGPLVTYGSDDESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PH37</accession>
    <name>A0A0G4PH37_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S015g000148</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793148">
        <property type="protein sequence ID" value="CRL25562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PH37"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF86">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
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    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
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            <end position="111"/>
        </location>
    </feature>
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            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
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            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL25562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="734" mass="83592" checksum="BCE809A3A46A9176" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PHB3</accession>
    <name>A0A0G4PHB3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S016g000013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793149">
        <property type="protein sequence ID" value="CRL25732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PHB3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PHB3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL25732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="309" mass="33949" checksum="7904033432924836" modified="2015-09-16" version="1">MKRKNLPKERLEVEFRRDFGHYRSSSAIVTACRKKRKADSRQKDVTSAPTPGRITLLAPVLNTMPVPRPPNAIIGTDTPSLHSSHTVAVPSNGNITLKPPPLERSRSHLTQPQILGNIDRFSCDMAPPLHESDETVDQSSPAAVASESASRQMVCWTPDSAEETPTLGNPRHRIEITPKPPSRLTAINGGNVHPTDPNSIAQPETNERDALPNGQGGHARRSIGAVGGTERVPGIVPPLIGIREWFEEERAKVFAMTTFPSCAINFSHRWKVDRPGANSARWGPILGERPTVQVYLFYSLRSPEGPRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PHC9</accession>
    <name>A0A0G4PHC9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amidohydrolase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S016g000066</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793149">
        <property type="protein sequence ID" value="CRL25785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PHC9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PHC9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000055">
        <property type="entry name" value="Uracil-5-carboxylate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF28">
        <property type="entry name" value="ISO-OROTATE DECARBOXYLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="135"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL25785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="383" mass="41974" checksum="658923FA2330C4EE" modified="2015-09-16" version="1">MSRPLVVDVHTHVYPPSYMAMLRARKTVPYIHDPASGEPRLIILSSDDDPSIPIDERGRPVDTSYSDINVKLTFMQQHGIDCSVISLANPWLDFLDPAEAQQWAERINNDLEETCARNNKSSNPDNNLPLQGRSTLFAFATLPLSAPSADIIVNEIKRLKTLPHIRGVIMGTSGLGNGLDDEQLGPVWAALEETQFLLFLHPHYGLPDEAFGGAEVTKRYGHVLPLALGFPLETTIAVTRMLLSRVFDKFPRLQILLAHSGGTLPFLAGRIESCIMHERKFVENGGDVPGPQRSIWEVLKTNIFLDAVVYGTAGLKAAVAAGGGTDRLMFGTDHPFFPPLNEGEKEWLSVTTNYKAIDATFEGETEAVAAVLGGNAARILKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PHN2</accession>
    <name>A0A0G4PHN2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S016g000100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793149">
        <property type="protein sequence ID" value="CRL25819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PHN2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PHN2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056021">
        <property type="entry name" value="DUF7600"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24539">
        <property type="entry name" value="DUF7600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="219"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7600" evidence="2">
        <location>
            <begin position="375"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL25819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1015" mass="113427" checksum="B3D00AEC13AF943B" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PHQ0</accession>
    <name>A0A0G4PHQ0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial substrate carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S016g000158</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793149">
        <property type="protein sequence ID" value="CRL25877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PHQ0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PHQ0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000112">
        <property type="entry name" value="Mitochondrial carrier protein (Pet8), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000123">
        <property type="entry name" value="Solute carrier family 25 (Mitochondrial S-adenosylmethionine transporter), member 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="13"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="111"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="240"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL25877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="338" mass="36121" checksum="9A49CB4414634ABF" modified="2015-09-16" version="1">MVQQADGEPLVSSLWTRSLISGAIAGLTVDCSLYPLDTIKTRLQKARDHTAPQTRVSLRQTFRGIYAGLPSVLFGSAPSAASFFIVYDGVKRTLLAPQPANSKTNPQSRSHIILTHSLASSLGEIAACAVRVPTEVIKQRAQAGLFGGSSLLALKDILSLRHAAPTSTTASPSAPAAKRGYSQVFRELYRGAGITIAREIPFTVLQFTMWESMKEAYGKRYLRTKETASSLAETQIPASTSAMFGSVAGAIAAGLTTPLDVIKTRVMLARRGDGGVDAPVRVKEIVRGIAREGPGAFWRGITPRVTWIGIGGAVFLGSYQYASNTLEGRREVQAEKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PI57</accession>
    <name>A0A0G4PI57_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription factor, MADS-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S016g000295</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793149">
        <property type="protein sequence ID" value="CRL26014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PI57"/>
    <dbReference type="STRING" id="1429867.A0A0G4PI57"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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            <end position="29"/>
        </location>
    </feature>
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            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL26112.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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    <accession>A0A0G4PIH4</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="471"/>
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        <source>
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    </evidence>
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    </evidence>
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            <dbReference type="RuleBase" id="RU003465"/>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="EMBL" id="CRL26139.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="579" mass="61797" checksum="5335461B27B5E335" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJ01</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Exosome_cplx_N_dom"/>
    </dbReference>
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        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686:SF8">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exosome complex component N-terminal" evidence="6">
        <location>
            <begin position="7"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Exosome complex component CSL4 C-terminal" evidence="5">
        <location>
            <begin position="89"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="44"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL26168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="246" mass="26620" checksum="E87DDE2E45E21522" modified="2015-09-16" version="1">MASLPPIAIPGQRLGPLSTYSAGPGTHVQQSFIYASIAGPVVADPAQPKSQTRPTLRVSRVISSKDQAGSTSAVPVASSTMSKPRYNTLPAVDSIVLARVTRVQKRQATVSILVVLDESASQPQDQSRTASDNDNVASILTSAANPENHSSTDELRFQALIRKEDVRAVEKDRVVMDEMFRVGDIVRGSVISLGDQSFYYITTARNDLGVVMARSDAGNMMFPVSWKEMRDPVTGTSEQRKVARPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJ52</accession>
    <name>A0A0G4PJ52_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S018g000115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJ52"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJ52"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL26422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="253" mass="28218" checksum="6F42A9C67C2F821B" modified="2015-09-16" version="1">MVFVLQNRKRKREESPASLACQPSLTKSSSSPSSYEPLTSPDHTAKLPSFNLEKESYKPLLTSMSPSGSPRHESQEADETSDSDYEEGDAVLARGWPRHHHNLAKHGFRPVWTSPNEYPGDEIPADIREWLDDNGQRISHGWRDSNSDNEFGPGFYTADSLDYALEYEPDSEAWNAWVAKWKHLPLEIARQPTPAEYDTADFIKGAVSEIGQSVRGGSAVPTQSETNQLVACSYEGCKALSNSLQMIIFVVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJ56</accession>
    <name>A0A0G4PJ56_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Amine oxidase</fullName>
            <ecNumber evidence="15">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PCAMFM013_S018g000057</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a primary methyl amine + O2 + H2O = an aldehyde + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16153"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:228804"/>
            <dbReference type="EC" id="1.4.3.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="15">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="14">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="14 15">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="15"/>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJ56"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJ56"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000019">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000014">
        <property type="entry name" value="Peroxisomal primary amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049947">
        <property type="entry name" value="Cu_Am_Ox_Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015802">
        <property type="entry name" value="Cu_amine_oxidase_N3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008559">
        <property type="entry name" value="PRK11504.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF86">
        <property type="entry name" value="COPPER AMINE OXIDASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02728">
        <property type="entry name" value="Cu_amine_oxidN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01165">
        <property type="entry name" value="COPPER_AMINE_OXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13 15" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="17">
        <location>
            <begin position="21"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase N3-terminal" evidence="18">
        <location>
            <begin position="111"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="16">
        <location>
            <begin position="238"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="13">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="14">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CRL26364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="683" mass="76295" checksum="ED4305F389A5B851" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJ71</accession>
    <name>A0A0G4PJ71_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Magnesium transporter NIPA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S018g000072</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
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</entry>
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</entry>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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            </authorList>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195611" description="glucan endo-1,6-beta-glucosidase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 TIM-barrel" evidence="11">
        <location>
            <begin position="74"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 beta sandwich" evidence="12">
        <location>
            <begin position="431"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL26496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="489" mass="51697" checksum="8BE9766D81AF5FC6" modified="2015-09-16" version="1">MILPSLLPILLLSAVADASPAKRATTASAYCSNSDGDYKLSSIAAPVQGSGNPGSESTWKLSIDDTSSGHKQTIVGFGAAVTDATVTSFNTLSSSTLQELLNELMTGAGAGFALMRHTIGASDLSGDPAYTYDDNGNNADPSMSGFNLGDRGNAMAAMLAKMKSLQSSLKILGSPWSAPGWMKLNGVIDGTTNNNNLNDGYLSRGGTGSTGYASAFAQYFVKYIQAYDNLGAHIDAITIQNEPLNSQAGYPTMYVFDYESAQLIKNYVGPALAQAGLNTDIWAYDHNTDVTSYPQNVINGASQYVDSVAWHCYASNVDWTVLTQFHETNPNIKQYMTECWTPASASWNQAADFTMGPLQNWASGVTAWTLGTNDQDGPHLSSGGCGNCRGLVTISNGGYTFNPAYYMMAQFSKFMPPGAIVLSGTGSYTYSNGGGVQSVASLNPDGSRTVVVENTFSNDVYITVSTNSGQEWSGNIPSQSVTTWVLPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKC2</accession>
    <name>A0A0G4PKC2_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">V-type proton ATPase subunit F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S019g000063</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKC2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PKC2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10580:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="entry name" value="ATPase, V1 complex, subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005772">
        <property type="entry name" value="ATPase_V1-cplx_fsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01101">
        <property type="entry name" value="V_ATP_synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861:SF2">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015945">
        <property type="entry name" value="ATPase_V1_F_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="AtpF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR015945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL26646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="124" mass="13933" checksum="34ACEB85F1811991" modified="2015-09-16" version="1">MAASAATYKERQFLAVIGDEDSVTGLLLAGIGHVTEPPDSQRNFLVVDSKTETSEIERAFQNFTQERKDIAVLLINQHIAERIRHSVDAFADPFPAVLEIPSKDHPYDPEKDSVLKRVRRLFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKL8</accession>
    <name>A0A0G4PKL8_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-2-hydroxyglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="7">1.1.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S020g000109</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2</text>
            <dbReference type="Rhea" id="RHEA:21252"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:16782"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.1.99.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the L2HGDH family.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.2" evidence="7"/>
    <dbReference type="EMBL" id="HG793153">
        <property type="protein sequence ID" value="CRL26950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKL8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PKL8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047545">
        <property type="term" value="F:(S)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104:SF4">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="9">
        <location>
            <begin position="35"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL26950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="408" mass="43907" checksum="02938907731CBC99" modified="2015-09-16" version="1">MSARALLKQQFKLKNKLPIRCFSSTRSTNADFTHAVIGAGVVGLATARQLAAREGTSTILLERHDAPGTETSSRNSEVIHAGLYYPATSLKTSLCIRGRNLLYDLCAQNNIPHRNTKKWIVAQTPTQWEACLKIHAHAQGLGDAPTRLVGREEAQQREPDVKADAGIVESETSGIVDSHSLMTYLQGDFEDRGGDIAFKTRVTSVEAIDGGRGGYKITAVSDEDGSVTSITAETLVNSAGHGACDISNMLLPQERHFVPHYAKGTYFSYASSKPRTSVLVYPVTLPGTGGLGTHLTLDMGGRVRFGPDVEWVDSPDDLVPSAARLERALPEIKAYLPGVDVDAIALDYCGIRPKLGRGGAVNEGKGFQDFIIREEEGLPGFINLLGIESPGLTSCLAIGEMVNGILYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PL80</accession>
    <name>A0A0G4PL80_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Frag1/DRAM/Sfk1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S021g000039</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793154">
        <property type="protein sequence ID" value="CRL27124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PL80"/>
    <dbReference type="STRING" id="1429867.A0A0G4PL80"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050911">
        <property type="entry name" value="DRAM/TMEM150_Autophagy_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324:SF2">
        <property type="entry name" value="EG:22E5.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324">
        <property type="entry name" value="FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="6">
        <location>
            <begin position="5"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL27124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="276" mass="30578" checksum="DC22B5E3170D645E" modified="2015-09-16" version="1">MWIISFWMFPLVSACMWVAMLIAMLVTWVKDGRPHYASMDDGQTIAYISDVGAQGLKPLFVAGSAVTVVFLDLAFLSERWLRHSNQLASNKGRLDKTCAILSIFFAIAGAAGLILLSVFDTLRHPKLHDGFIGLFIAGYVVSAILVCIEYLRIGIFYRREHRVLLVSFFIKLVFVIVELALAIGFGVCIGSNQSSKQNPGAVLEWTIAFVFTGYVLSFVVDLLPSVRTRNHVPQGEKYLMNQGGFSGTREEGVSIEEPLTHDSMGPTTGFYRGQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PLG0</accession>
    <name>A0A0G4PLG0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Beta-ketoacyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S020g000150</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG793153">
        <property type="protein sequence ID" value="CRL26991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4PLG0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF13">
        <property type="entry name" value="POLYKETIDE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="9"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="11">
        <location>
            <begin position="893"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="2361"/>
            <end position="2438"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="893"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1044"/>
            <end position="1187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL26991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="2444" mass="267366" checksum="DD9A0120D88BCD00" modified="2015-09-16" version="1"> </sequence>
</entry>
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    <accession>A0A0G4PLI9</accession>
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        <submittedName>
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        </submittedName>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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            <begin position="1"/>
            <end position="18"/>
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            <end position="159"/>
        </location>
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        <location>
            <begin position="70"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL27234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="573" mass="59114" checksum="5563A00559CC05C0" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMA5</accession>
    <name>A0A0G4PMA5_PENC3</name>
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        <alternativeName>
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        </alternativeName>
    </protein>
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        <name evidence="10" type="ORF">PCAMFM013_S021g000221</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
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    <comment type="subcellular location">
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            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
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        <text evidence="3">Belongs to the EFG1 family.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="EFG1_rRNA-proc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33911">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33911:SF1">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10153">
        <property type="entry name" value="Efg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
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        <location>
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        </location>
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            <end position="333"/>
        </location>
    </feature>
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        <location>
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            <end position="13"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="CRL27306.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="333" mass="38288" checksum="1508C73464ED4F68" modified="2015-09-16" version="1">MSTDTRSHRDRAAPSKRKTREGSEDVPPARKKVHRKADKADDQVQFEDYGSKGDASKPKVTRKYKDKFAPKPEKEYPSINDLKKRIRDVKRLLNKMDLSADARILQERALAGYEQDLADENTRRERSSLIKKYHFVRFLDRKTATKELNRLTRREKEEDLDSKQKARLAAKIHTCRVNLNYTIYYPLTEKYISIYPSGKPDATDPESELQTQETKSNDAKPPMWSVVEKCMEEKTLDLLREGKLHINANGEKIQASSSSTTTVTDTHKEKSKKGEQQKETKTSTQKEKHASKDDKKSSKKEKAARNERAPKKHEASEPANAEDQDDSDGGFFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMF6</accession>
    <name>A0A0G4PMF6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CDAN1-interacting nuclease 1</fullName>
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    </protein>
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        <name evidence="10" type="ORF">PCAMFM013_S022g000002</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
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                <person name="Malagnac F."/>
                <person name="Goarin A."/>
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                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CDIN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
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        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31661:SF1">
        <property type="entry name" value="CDAN1-INTERACTING NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31661">
        <property type="entry name" value="SIMILAR TO CDNA SEQUENCE BC052040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14811">
        <property type="entry name" value="TPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNase H type-1" evidence="9">
        <location>
            <begin position="382"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL27323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="708" mass="80731" checksum="E86AA46FAFF2ED14" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMK5</accession>
    <name>A0A0G4PMK5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S022g000053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793155">
        <property type="protein sequence ID" value="CRL27373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PMK5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL27373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="209" mass="22781" checksum="2A26160CC583F964" modified="2015-09-16" version="1">MHIQSVKKLAMESHSYRLAVPTLASLKPTYTQAIGFRTSQALYDEGSRLDVIPVSKQFPLSALYLPLYCDLLLHSSSLVSALSDEPTTESKHNGAITEKGLITGAIRGSYTSTATKTSDHEWHDTAIYGSNLSARLSKQGAVLILSSVFRGSVALIGVFIIHCFILRYLHGHAMGSTSLVPSQRVVDSSEKRANVIPRTAEFSHFSNDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPE2</accession>
    <name>A0A0G4PPE2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S027g000006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793160">
        <property type="protein sequence ID" value="CRL28317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PPE2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PPE2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009784">
        <property type="entry name" value="DUF1349"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332:SF2">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07081">
        <property type="entry name" value="DUF1349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL28317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="196" mass="21596" checksum="DA9BBD39B6D1F628" modified="2015-09-16" version="1">MSQSQFKFVNSDAEVPGNGSPPPEFTINAPASTDIWAKPPSTTRFSAPILYKSVSLKSFKRIRVAFNAPWEKNYDQGGIILVLNTADGGQKWVKSGIELTHGRPHLSVVAKDNWADWSLLPVPSGGGAATLELVKEKDNSLWIYLVEGLQKSPIREVTWVFAEENVKDFWVGVYSARPSSEGGELPVNFGHLIIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPK0</accession>
    <name>A0A0G4PPK0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S025g000124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793158">
        <property type="protein sequence ID" value="CRL28066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PPK0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PPK0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03139">
        <property type="entry name" value="GATase1_PfpI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF3">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR RV1931C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="1">
        <location>
            <begin position="11"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL28066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="235" mass="25112" checksum="A69CE1CB06E63A65" modified="2015-09-16" version="1">MSSESPNKYYKVGVLLFPGADILDFAGPIEVLSHVLHNRNPDSPDRMFEIKTVACSPAIRAANSLTVHADLLLPDAVDQISDFHILVIPGGPPAVLQPLLESNAPELDLIRKYAALPADKSLGTRTLLSVCTGAFLLGAAGVLGGMTVTTHHHALDRLRDICAHSNTPGEPGTTVLHKRYLDGGLLKGGGVRLLTAGGISSGLDATCYLVSQLATHDMAAFIVRVMEYDWRELEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPM7</accession>
    <name>A0A0G4PPM7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glucose-methanol-choline oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S027g000051</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793160">
        <property type="protein sequence ID" value="CRL28362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PPM7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PPM7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF210">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL28362.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
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</entry>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </feature>
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            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL28208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="146" mass="16231" checksum="BD55DFEB549659D2" modified="2015-09-16" version="1">MDGSTGGATAIKKMASSKYRSISDLVESFKSSWNNKLVTRQSSEYTTEETEEIEKCIELICCLDGPEWHTWRSNFDALVSKTANPIDLYQFDRICGELNREEKALNGKKKATKANATTSKATNNDDSSETTLVTNANSKDILTISF</sequence>
</entry>
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        <submittedName>
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                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
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            <end position="105"/>
        </location>
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            <end position="140"/>
        </location>
    </feature>
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            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL28534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="236" mass="25841" checksum="4E0974744D09696C" modified="2015-09-16" version="1">MTSNSSLTGSGGAYSSDMEESSFLKRNRVIHLARLGLSFLIFGVAIAVVACEAPPLRHYKNTSQWASAGLALWPLNFDLRPTIAAISCGCVITILNLVYITVALLPSPHSRIKSLNIYASASAIAGFSTALVGILFIIYLPSSDYPAGFSKNETLHSWTCKWKTGTSSTSTPRHFDRDCVNTRAGFVLLCVLLGMEVLMGLVAAVGTWFQRDVSRRRAEQFQLEKLEIATKQVYRN</sequence>
</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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                <person name="Abraham A.L."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </location>
    </feature>
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            <end position="126"/>
        </location>
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            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL28559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="287" mass="32150" checksum="7E0A369529739A09" modified="2015-09-16" version="1">MTTPNSQSLDIEDAARRALRYLHGLQEFRQIQILVTGDLALSNYFPGSGVGNNVEFLVFLGAGFDDRLDELPSGVPDLLKSRLLSMYPTEFQQPLNVFQIKRIPGIPGESDTPCEPDTPGEPDTPGEPDTPGEPGEPPGIPLRFIPNGILPYLPRGTTTIAAIGQTHAIDLPYISSLDLFVFMVISHDMGVKTPKPLKEETPDEETPDEETQDEETKDEETKDEETKDEKTKDEIDVKMLQHFLRHLKSIGPVIFSPQQKESLTHGLNWLTTYSQWSEAQWIRKLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000097">
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    </dbReference>
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        <property type="entry name" value="Calponin domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000223">
        <property type="entry name" value="Related to alpha-actinin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="10"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="124"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="484"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL28647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="639" mass="73783" checksum="7B4A3CF46C2050DC" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQI6</accession>
    <name>A0A0G4PQI6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA replication complex GINS protein SLD5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S027g000097</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GINS4/SLD5 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793160">
        <property type="protein sequence ID" value="CRL28408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQI6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PQI6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11711">
        <property type="entry name" value="GINS_A_Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21692">
        <property type="entry name" value="GINS_B_Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008591">
        <property type="entry name" value="GINS_Sld5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031633">
        <property type="entry name" value="SLD5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038749">
        <property type="entry name" value="Sld5_GINS_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206">
        <property type="entry name" value="SLD5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16922">
        <property type="entry name" value="SLD5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007764">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="8">
        <location>
            <begin position="75"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication complex GINS protein SLD5 C-terminal" evidence="9">
        <location>
            <begin position="213"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR007764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL28408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="270" mass="29865" checksum="52406D2562FA0D4D" modified="2015-09-16" version="1">MDIDDILASVDRGPGASPESAALDHQLLTRFWVAERAVSEVLPWPAPLMERIMDRVRIQIETIEDLAASSDTTLPTTPNTHNPNLNLRLSILQTDLARSQYIVRSLLRARLAKITKYSMHYLVLLASRNKNPLASQTQSTASSQNPNQQPEDSVPDISELTDLAPLSEPESSFLHAHQTLLAGHYAGSFMGAFPRQLRRLDDNAGGTSMIQGPELREVVFVRCLGAEVPVVVGGEEEQYETGVTMRMGDVWVVRWEGVKAAWGRGEVELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQP4</accession>
    <name>A0A0G4PQP4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Homeodomain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S030g000069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793163">
        <property type="protein sequence ID" value="CRL28782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQP4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PQP4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="24"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL28782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="267" mass="30505" checksum="B57569828FD6D182" modified="2015-09-16" version="1">MHLPGIVPYHRLRARSHGRHSYADRAETTRTLNLIQEKALTSWVQTLDSAHISSTPEIVEDAANAILKKAGENRVVGHNWAYRFLARLPLRLNYIKQKPKEKSRVESEDYGALLLWFNHLSRVVNRHQFLPHKIYNWDETGYRIGQGKHKVITSRTSSDIPTGGQSESITGIECIAADGWLMLPWFLPKGSLLMEEWSPPGIFTPSPPPDFSSSVTNSPPDTIERVEKLNTKLINDLERIEHLQKSVNRHIQRSIDANTLLSQEMNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRE1</accession>
    <name>A0A0G4PRE1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Complex III subunit 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S032g000025</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the UQCR10/QCR9 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793165">
        <property type="protein sequence ID" value="CRL28989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PRE1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PRE1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.260:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.260">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008027">
        <property type="entry name" value="QCR9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036656">
        <property type="entry name" value="QCR9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12980:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12980">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX, SUBUNIT X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05365">
        <property type="entry name" value="UCR_UQCRX_QCR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81514">
        <property type="entry name" value="Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL28989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="75" mass="8767" checksum="740B873EFC984443" modified="2015-09-16" version="1">MAGFANAIYSHALFSVYRTFIRKNTVLLTTAFAGAFAFELAFDITSNKVWDSWNQGRQWKDIKHRYVVKEEEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRE9</accession>
    <name>A0A0G4PRE9_PENC3</name>
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        <submittedName>
            <fullName evidence="1">Kinetochore subunit NKP2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S030g000025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="INNER KINETOCHORE SUBUNIT NKP2"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF09447">
        <property type="entry name" value="Cnl2_NKP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL28738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="197" mass="21772" checksum="0AB7DEFE01D48CE7" modified="2015-09-16" version="1">MSPSEESILSNFLLSPAPLPTVMSLQKFTELFPKRLRAHPHIRTLYRELQQVREQDMDRVNESIDNEIKQGERQRAELRKAMLATGVEASSSEEQREMDMDLHLFGQPPTAAPGDYHSVASLLAEMETASANIEHEIAGIDQEAAEILAQLSTTVGDMSDLRYGKLQGPAGTAEDVADEAIKGLQNLEDVCYKSSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRJ5</accession>
    <name>A0A0G4PRJ5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">PCAMFM013_S030g000075</name>
    </gene>
    <organism evidence="3 4">
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:magnesium ion binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAD-like_SerB"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="URACIL PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="2">
        <location>
            <begin position="492"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL28788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="692" mass="76721" checksum="29238706A92E9D2E" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PSF7</accession>
    <name>A0A0G4PSF7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sugar/inositol transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S033g000023</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793166">
        <property type="protein sequence ID" value="CRL29103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PSF7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PSF7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000254">
        <property type="entry name" value="MAL31p Maltose permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF49">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="425"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="461"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="73"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL29103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="564" mass="62923" checksum="FBF6CE44177CE6BF" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PTS4</accession>
    <name>A0A0G4PTS4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aspartyl-tRNA synthetase, class IIb, bacterial-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S041g000017</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793174">
        <property type="protein sequence ID" value="CRL29875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PTS4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PTS4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04321">
        <property type="entry name" value="ScAspRS_mt_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="entry name" value="GAD-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00459">
        <property type="entry name" value="aspS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001750">
        <property type="entry name" value="PRK00476.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="7">
        <location>
            <begin position="236"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL29875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="681" mass="75645" checksum="11C59A02CB8FEF9E" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUE8</accession>
    <name>A0A0G4PUE8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S043g000018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793176">
        <property type="protein sequence ID" value="CRL30023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PUE8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195633" evidence="2">
        <location>
            <begin position="27"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL30023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="263" mass="29245" checksum="D87B1EF3FEB43798" modified="2015-09-16" version="1">MEIPTSVHAALATVLLCLCLVRLVLSQRAVQENSLHQKLDLALSLPMIALQAVLVGLSWGRPIGTEMEVIVGFTSLFPSLLGYLRMIILLRNLPKAPYVWRMCLPSIALSSGLVKVMATLLGTYVHHPLQFIVLFVLFVDYLGLASFLWWLNGDTTARSPPQVQLRCALYCTYGVTAVMLFMAILGAVMDCWLLFLQCKTITAIKRSRPWPTPQYEGPKWPPWLRTVANIGKNTRSFQQGQLFSIPASRVSSVILVTLDTLCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PV25</accession>
    <name>A0A0G4PV25_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sugar/inositol transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S042g000063</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793175">
        <property type="protein sequence ID" value="CRL30004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PV25"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015793">
        <property type="term" value="P:glycerol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF69">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="18"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="509"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="518"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL30004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="528" mass="58108" checksum="3C14C3A6BB613774" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVN6</accession>
    <name>A0A0G4PVN6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein PNG1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein png1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S054g000023</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglutaminase-like superfamily. PNGase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793187">
        <property type="protein sequence ID" value="CRL30566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PVN6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PVN6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.620.30:FF:000004">
        <property type="entry name" value="Peptidase (PNG1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000011">
        <property type="entry name" value="peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF19">
        <property type="entry name" value="PEPTIDE-N(4)-(N-ACETYL-BETA-GLUCOSAMINYL)ASPARAGINE AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="7">
        <location>
            <begin position="243"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="403"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00071430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL30566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="444" mass="50378" checksum="2434F4ED85E6C925" modified="2015-09-16" version="1">MADGRHRANQPAPNGYDASSLTHEFEQLMRTKRLNRLHEPSRSHNNTPSPSPMSSSAFPPPPTRAPPPPPSLGTPAAAPSPKPSTTPSALRGLPIMPSPPQEPASLKFYNLLKGLSVTPTKYENPGLLDEALSLIPLDRLYSEAEEESQIMQAQAASVGGKPEWGYQDCVIRALLRWFKGSFFQFVYNPPCSRCHMPTIAQGMTPPTPDETARGATRVELYRCSDASCTADERFPRYSDVWQLLQTRRGRVGEWANCFSMFCRAVGARVRWVWNSEDHVWTEVYSEHQRRWVHVDSCEGAWDQPRLYTEGWQRKLSYCVAFSIDGATDVTRRYVRNFSRHGNPRTRAPEEVVLWSIHEIRRKRRENMSKTDQRRLIKEDEREEKELRCYMASALAAEINNMLPQGLTGRPEDQKHPGARPEASTEWLAARGHGNSGPDRSREGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PW02</accession>
    <name>A0A0G4PW02_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S055g000014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793188">
        <property type="protein sequence ID" value="CRL30599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PW02"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL30599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="87" mass="9990" checksum="EB8CD789617AC3A0" modified="2015-09-16" version="1">MTSRKTRETARYPLNRGDGRLEKSQPHRTDCKVHDFPTPWIVAPSTASTQTSDGLAVIVAALVFFSFLFASKVTNYERRQVFHRVHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PW48</accession>
    <name>A0A0G4PW48_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alcohol acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S050g000036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793183">
        <property type="protein sequence ID" value="CRL30389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PW48"/>
    <dbReference type="STRING" id="1429867.A0A0G4PW48"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052058">
        <property type="entry name" value="Alcohol_O-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010828">
        <property type="entry name" value="Atf2/Sli1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037:SF1">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07247">
        <property type="entry name" value="AATase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL30389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="454" mass="50276" checksum="4B7BA39251C28FBB" modified="2015-09-16" version="1">MEEVLPEGGFAPLRLLGHAEKYSTTRSHLGIYLNVGLTACYKRPNGVPVKPALFYALSMLISKHPILSAIPFAVGTPDPYFVRLPKITLSEVVSFMEDEANFPSSDERQTLDKVLQEQHNCPFEIDPKRPLPFWRLCVLERSSCPRSFILVFVFHHSLMDTQSALSFHNELERYMAQYAGLEPSDTVYCPSNALIPPLEGLCTLPVSREFLQSQEKDSELSPDGWTAAPQFTPVKTRFSSLWLSEVDTKVLVTLSKQEQTSVTATIQVLVATCIFSALPATYHTLQGDCAVSLRRFLPEPVTATTLGCYVGSLSTTYHREPSFNWNESRRTKVAIEHAMAQKGGNMPVGYLALIQNQHHWMLQKMGQNRKSAFELSNIGATSTLRGGTNFEIESMLFSQSSSACSAAIKVSAVTGPDGRLALGFTWQEGAIEVGMIEKVQSALKGEIERLAVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PWH2</accession>
    <name>A0A0G4PWH2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S052g000039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793185">
        <property type="protein sequence ID" value="CRL30482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PWH2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL30482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="34" mass="3749" checksum="43A133AA3CCEA6F3" modified="2015-09-16" version="1">MEKASEDLIVDATGVRRFDVRLCDPGLDKPDAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PWH3</accession>
    <name>A0A0G4PWH3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S053g000042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793186">
        <property type="protein sequence ID" value="CRL30534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="90" mass="10373" checksum="E5C12D68F0912677" modified="2015-09-16" version="1">MNTRRQAHATRSIRASSPRPYSSLRANKILRVRIYHRSYGSHVTLSTGQPGKPQIAGAKQGSRDKPAISEREATRLDWMRRLRPKPHRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PXX7</accession>
    <name>A0A0G4PXX7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S088g000003</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793219">
        <property type="protein sequence ID" value="CRL31210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PXX7"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL31210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="360" mass="39452" checksum="FE0D8B60D4F683CE" modified="2015-09-16" version="1">MEHTSPKGGPSSPPPREPRLHLPSTTDPPGPQNPAKPLVWLIFGATGHMGRSLVKTALSNNDLVAAVGRTYENSPAAMKELESPNCIGLLCDVRARETVKRVIDQTISHFGRIDIIANCSGYGVIGACEDQDEFDIRNQFETNFTGTLNMIQLSLPHFRQRRAGRYLIFSSTSGALGVPGLGPYCASKYAVEGLMESMLYEVDSFNIKGTLVEPGHMRRDDIADLVSAQAPNPSEHQLSAPLPLYGHFLVKPPSDPYNTTTSPAAHARRMLMWLGDKQPASAVKAAHLVWQLGHCSYPPLRLILGTYAVESVRDRLKCIIEEIEDWKYLSFPMGDTQLPVRSERERSSFQEGAEGGSGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PXY9</accession>
    <name>A0A0G4PXY9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Aromatic-ring hydroxylase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S069g000012</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793202">
        <property type="protein sequence ID" value="CRL31046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4PXY9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF15">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03030)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="215"/>
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                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="165"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
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        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="102"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF05433"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL17337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="211" mass="22043" checksum="7F645776AF379E91" modified="2015-09-16" version="1">MSGYDQYNQGHGQQGYGQQGYGQQQGYGGQQGYGGQQGYDQQQQYGQPQQGYGQQGYGQQQGGSSDYYAGQQHQQQGYGQQQGGSSDYYAGQQHQQQGYGQHDQNRQGGYEQQQGALGDAQDGERGLAGALAGGAAGGFAGHKVNHGFLGTIGGAIIGSIAEDAVKKHRNKDDQSPPQYGAPPPGGQYGGPPSNSGSGGSMMDQLGGFFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NU62</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
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        <location>
            <begin position="21"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL17600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="121" mass="13360" checksum="563C110638897E7B" modified="2015-09-16" version="1">MKVFTPIFVLMAFATSQAIATPTAEGTDLETRADFCVDISVCHGYNYEGGCYSECNRPGQGYGIKQEYRKNAGSFKIGTKGYNCQIGSSNQGTDPVDYPGIKRFKDGWINNIEGYQCNKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NVE1</accession>
    <name>A0A0G4NVE1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Str. FM013</fullName>
        </submittedName>
    </protein>
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        <name evidence="9" type="ORF">PCAMFM013_S001g001026</name>
    </gene>
    <organism evidence="9 10">
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
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                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1429867.A0A0G4NVE1"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF155">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="236"/>
        </location>
    </feature>
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        <location>
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            <end position="277"/>
        </location>
    </feature>
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        <location>
            <begin position="34"/>
            <end position="280"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL18066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="378" mass="41923" checksum="D327D46AB6834F2E" modified="2015-09-16" version="1">MATTDAEYIHQKKGPRILGVFWAFYSVSAVMVSLRLCIRARMLKNIGLDDYIIVAAMAMVTSYTVLTTVIVVLGYGSHTSVLMEKGGMDLVERILVLNYANFALGIMSFTTPKLAIAALLNRIMNPSRFHRIWLWILTGFVFMASTICIIVLFTMCDPPQALWKIHLMSEGATCRSTTILVGYAIFTGVLSAMVDLYLAIYPTVVLLRLQMSLKKKLALCAALGLGAVACAMAIVKCLQLPGLYNTADSTYATADLVIWTSIESNIVIMASCIPTLGPMYEMIRGKRSWSSHGRYDSGKLRSYTDRPTRKSASNNREDDDILMTTNIGTTRSGSQESILNSDQPRKEAHVAGKIHRTDQVKIEYGERPQGDHEPRPSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NVU9</accession>
    <name>A0A0G4NVU9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S001g001059</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793134">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4NVU9"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF6">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
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                <person name="Lacoste S."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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            <end position="44"/>
        </location>
    </feature>
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        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL18406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="308" mass="33536" checksum="FBFE4B43A68C31C1" modified="2015-09-16" version="1">MRTQGKTTNSSAVGFDHVYFDDNEDESPAQEYTPSQRDSTNAIPEAVPRVNRAKEPYRSFNVFKDVALGTNAFSFCLQVHPSGGLAQSPSPVYHTLRIPWYRQGLYLPASFDLYSGGNVVRSRKDPSPEPQDHRAHIHYRGFEGLLSLHVTVDIFRQVGSSALQNDLVGSGRSSPELSKHCSVDIVRKGIGRTYRVGITGGGGTKTFYWKGSKTALSLLETEGKKSAGSSDGNGNLKFFSADKPDDILAVWQNRTDRQILGSLNVIAELDPDSDGVLEALMVSCLAVVVAERVSGRGWIGGLGKSRNS</sequence>
</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glycosyltransferase family 1 protein"/>
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    </dbReference>
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        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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            <begin position="110"/>
            <end position="273"/>
        </location>
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            <end position="534"/>
        </location>
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        </location>
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            <end position="10"/>
        </location>
    </feature>
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            <end position="744"/>
        </location>
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            <begin position="745"/>
            <end position="756"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
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        <source>
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        <source>
            <dbReference type="EMBL" id="CRL18776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="955" mass="106099" checksum="78D6C7636D1A82C3" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXU5</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PCAMFM013_S002g000782</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
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        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
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        <property type="entry name" value="MurA_subfamily"/>
    </dbReference>
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        <property type="entry name" value="aroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43783">
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    </dbReference>
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        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL18912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="718" mass="78166" checksum="B0C598EB12708684" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NY15</accession>
    <name>A0A0G4NY15_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S002g000857</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NY15"/>
    <dbReference type="STRING" id="1429867.A0A0G4NY15"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="58"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL18987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="227" mass="25737" checksum="3EB0BC5FD99D3C48" modified="2015-09-16" version="1">MSETTNNHQIKDDIKKAYDEIAEVYLDWTQPSHEVRLSYLDRMLRSLDPAKGNSQISILELGCGAGVPCTELLASREYIRVTANDISETQIAMAKKRLPESVNLIQGDMMELEFSPAHFNAVMALYSIFHLPRNEQTTMLRRIFDWLKPGGRLLANFPETGFASSSDQSWLGGTKGAMHWSGWGKDEMRRLLTEIGFEIEIDEVVVDCEEKNGVSQSVPFHWILAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYE1</accession>
    <name>A0A0G4NYE1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein FYV10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein fyv10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S002g000946</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FYV10 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL19076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NYE1"/>
    <dbReference type="STRING" id="1429867.A0A0G4NYE1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044063">
        <property type="entry name" value="ZF_RING_GID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN TRANSFERASE MAEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51867">
        <property type="entry name" value="ZF_RING_GID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CTLH" evidence="12">
        <location>
            <begin position="164"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="RING-Gid-type" evidence="13">
        <location>
            <begin position="329"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-Gid-type" evidence="10">
        <location>
            <begin position="329"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="73"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CRL19076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="406" mass="46213" checksum="E55BFD4A13951A99" modified="2015-09-16" version="1">MAAELTSTKLNPESHIILDQPLLRLPHELARRNFKTVQRAVEREKEYVIPALKETASASLSNTQTPDQTLAALDAMISRMQGLKRKMESLQEEEKKIHNQSRKRIQHLETLHKIPSLADVKYDQWSRVRLDRLLVDHMLRSGYSESAKQLAQDRGVEDLVDLGVFTQCQRVVDSLRRGETKEALQWCGENKAALKKSQHNLEFELRLQQYIEMVRTQDKSKKIEAIIHAKKYLIPNHQSQNSEIMRAAGLLVFTQDTRAEPYKSLFALSRWKYLAQLFIQTHHELLSLPSQPLLHIALSAGLSALKTPLCHSAFTSSSSNSQSTSTSVCPICSTELNELARKMPYAHHSKSYVESDPIVLPNGRVYGKQRLIEISRKMGSVESGTVKDPTTGEVFQESEMKKVYIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZC3</accession>
    <name>A0A0G4NZC3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S003g000199</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZC3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005194910" evidence="1">
        <location>
            <begin position="23"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="2">
        <location>
            <begin position="403"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL19408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="508" mass="56481" checksum="0EACCF02801E03E3" modified="2015-09-16" version="1">MFFSLPVLLSTATFITSGKCSSDIIPVPSSPKNSSPVPNDLQSISIEFSYFPDYAGNKSQPNEFSKNLLHNLRTLTGVAPKVRVGGTSQDHATYFPDQEENVKLFYQNPTDDQPIQINYGPTFFESYHTLGEIKFLHGLNMNQNSSIQQLQDSATEACTSIGPQLHLFELGNEFNFAPGKYRAANYSLLDYVEEWNSKSAIVKSAVQKVCPGSFPGFMAPSLVLLDFIDDTTWTAEDLYNLGYDKDDLTKELCFHNYMGVNAAPLPPAQLDLQRTLMNHTNIMQNLAPQIKRAENLAYLGLPYTLGELNSIANQGVNGETNVFGDALWLVDFSLWAAVHGIKRLQFHQGLNYRYASWQPIESKGLPPTTRPPYYGQIMVASAIGQSKDTRIVNIPLSEDTESAYAIYNGDQLSKLVVTNLRAFNQTTSDRPHRKYEFHVPAQYKSARIERLIGPGSDALDNITFGGISYDYALNGGKPVQQNMNEETRIQNGLLTILVPDSSAVLLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZK4</accession>
    <name>A0A0G4NZK4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S003g000297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZK4"/>
    <dbReference type="STRING" id="1429867.A0A0G4NZK4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="8"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL19506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="330" mass="38150" checksum="5920211D4FED7CFF" modified="2015-09-16" version="1">MADAKMIKLPPEILITIFANLLRSDLISVSLISWKHRYLSLPYLFHTLNVNSTISGLQCLESVSKSILSKYMKTLCYEASELINPCIQHFDYFETCIYTPSEFLRDQKDLFWSNQQETVTYTSIHSYFNCLSKEQQNILDTREDLNVFCSSIPRFSSLHSVHITFIGGVNNRYLWFAPRVFADWSYSFLIHLETIIEAMIVAKENDILVRCFQISGFYARLRACGGALRDKIADGLSNVETLCLDDSPNLIDFMSNIDLPALRRFELGRCWITCADIQKVLNAHSQIQCVQLSKIWFPERLRFELSALGHIQGEYHDQRAEENITIIVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0R1</accession>
    <name>A0A0G4P0R1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S003g000661</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P0R1"/>
    <dbReference type="STRING" id="1429867.A0A0G4P0R1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF163">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_8G05510)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="47"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL19869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="380" mass="42526" checksum="6ADBA99EF7961E4B" modified="2015-09-16" version="1">MAIADMNMTSIFGPPPAGMDLAESRTFEDTAVVVTICMLAVCTIIFRLVVRGYIQGARLEADDWLIGASGIPLIALLAASILGGTYGFGLHVWWITVENMVTMKKILFAYLIVYLFELLLIKVSILMFYRRIFGMNWTIWTTLVISYGWCIGSMIAALCACEPISYFWREIIDPTSGSNRYNFYYYYVGNAAANVVTDVLILLVPVPVVWSLQMRKTQKIGVCGVLLLGGFVCVASGIRIHYITYLHNNIDITWALGDVAVWSTIEPCIGIICACLPVLQPFVRSLVKKMPSLPTQHIGTSRMPSVIHRISLHKLQSSKYDLESRTSPTPFGDSEEDLDPLTSVRTRVEIETDLKDRVIGEQNLDPMAIRVKRVVHWSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0R6</accession>
    <name>A0A0G4P0R6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S003g000714</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P0R6"/>
    <dbReference type="STRING" id="1429867.A0A0G4P0R6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049174">
        <property type="entry name" value="Beta-AFase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43465">
        <property type="entry name" value="DUF1680 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G08910)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43465:SF2">
        <property type="entry name" value="DUF1680 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G08910)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL19922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="227" mass="24731" checksum="7BDABDC10B6131C4" modified="2015-09-16" version="1">MMTTKDDLTVFPVVLSRILHMSNRGLLSSVHDGHGFTFLGSSFGFPSRDIIRTPIVWRWSNDVVGQLVEGHSIAGSQGDQGTQLVAGLGYCPTAELGGCTIRDIEAGGDTPGYPDHPEIELALLHLYKVTGNEKHSKHARFFIEERGNPTGGTERRHYHDVESGARGENKNTLPVLVSAHVPIAEQETIEGPPVDLQLRLGIPGWAKLRQATPSPEQLGLRKGYLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0S0</accession>
    <name>A0A0G4P0S0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PITH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S003g000665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PITHD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P0S0"/>
    <dbReference type="STRING" id="1429867.A0A0G4P0S0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.470:FF:000003">
        <property type="entry name" value="DUF1000 domain protein (AFU_orthologue AFUA_1G09230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045099">
        <property type="entry name" value="PITH1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175">
        <property type="entry name" value="AD039 HT014 THIOREDOXIN FAMILY TRP26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175:SF1">
        <property type="entry name" value="PITH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PITH" evidence="2">
        <location>
            <begin position="19"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL19873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="220" mass="24341" checksum="EF39742EB7FF3150" modified="2015-09-16" version="1">MSGHHHDHDGHCHGEHDHTNDITPAIQSLLYSQINFDLITTLNETTPNSGASIVQKTWAERLNDKPELESDADEQLLMTIPFNGQVNVHSLLLYTAPTNSAPKTVKLFKNRDDLDFSTASELHPTQTIEVPQPVPGADVFELPLNRAHWNATTSVTLFFEDNWSDGEEDVTKVGYVGFKGQFMKLTREPVNFLYEAAANPQDHVSIPGVSGVGGRIMPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0Z6</accession>
    <name>A0A0G4P0Z6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S003g000778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P0Z6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL19986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="487" mass="54967" checksum="3E6F793BAAF05B7B" modified="2015-09-16" version="1">MSEDFESLPPAVRRKFFSNVERLRIRLAQSDHGSPTCSTSNYQTDNRVYRTPRLGSDYHSRGFRNGSRKRGLEKRSSPSKKLRQPGSLQLAYLAAQADSQCFHTLPAKIQQKLFSPEERRRLRNAYRQSLIYDAADEAYHRDSGNSRPSTGTHLSQTTASQTTVSFVQPSTVFYSDSESDEEDPNMDQTFHDSFRWLDEDGDLDLSLDEYHAHVADAATRKRTRPSFRRSLSFSNHLRKTLEITPISARGLPPVNQSQPLTPLSNRTPDSRPSSSHRFQHAAQSSTSSIDPCAQYYQDPDARLKLRVYLASPQKFDEAIEFGFPSLDQNKENIGPEPITPQQSSPKPTLVNSDFGTFFEDDDGTMVGSPGGSVVNEPIPSPVFSHRDVPRPSVESSALLQRRQSWMPGAKGVPQRLPGNREMTLKMTLTRPDLRTDSPTSPASSKEKEDPLRLAALPPADRSQSIWDSDLDDQGMVKKMWRKLRRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P174</accession>
    <name>A0A0G4P174_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alcohol dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="9">1.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S003g000826</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15937"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:15938"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:15939"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.2" evidence="9"/>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL20034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P174"/>
    <dbReference type="STRING" id="1429867.A0A0G4P174"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008106">
        <property type="term" value="F:alcohol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000158">
        <property type="entry name" value="Zinc-binding alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="21"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL20034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="360" mass="38283" checksum="C0DBBBEB36554B7F" modified="2015-09-16" version="1">MSSTDYKFEGWVGLGPEAAEGKMVWQEFEPKPWEETDIDIKVTHCGICGSDLHTLRSGWGPTNYPCCVGHEVVGTAVRVGSQAKGDIKVGDRVGVGAQSGSCQNKDGDCESCASGLEQHCNKMVGTYNGIYANGGKSYGGYSTYNRSPSHFVIKIPDAISSADAAPMLCGGITTYSPLKRNGCGPGKTVGIVGVGGLGHFAILFAKALGADRVVAISRKSDKKEDALKLGADDFIATGEDEDWATRHASSLDLIISTASSSKMPIVQYCGLLRVHGTFIQLGAPEDGALEIPAFVLIMKGLKLGGSLIGSPDEIREMLELAAAQGVKPWIQERPMKDANQAIVDMDNGDARYRYVLTNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-11-27" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P193</accession>
    <name>A0A0G4P193_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S003g000846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL20053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P193"/>
    <dbReference type="STRING" id="1429867.A0A0G4P193"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055222">
        <property type="entry name" value="PRISE-like_Rossmann-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22917">
        <property type="entry name" value="PRISE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRISE-like Rossmann-fold" evidence="1">
        <location>
            <begin position="72"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL20053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="192" mass="21977" checksum="E1CE2705A9694528" modified="2015-09-16" version="1">MQGRSRGLDQVVHMSYCGMCHDVRNEYMDDIQNEPPLKEDNPRIPSPARDEIFYYSQVDLIKGGRQGYFSMGPSLTFPDAKDKFTYTYTQSAQDLMSKSEIYLSAVKPEESNGEALNVADTAPRRSWSIKWSFIASYFGPNGIDAGQLGGEQVDLLWNEHQHDYRNVQDIWTCSSRDASIFMCLLQVRLYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P1F6</accession>
    <name>A0A0G4P1F6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Polyprenyl synthetase-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S004g000090</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
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        <property type="protein sequence ID" value="CRL20150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:alcohol biosynthetic process"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF69">
        <property type="entry name" value="ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL20150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="447" mass="48870" checksum="D5B5F9F779CC5046" modified="2015-09-16" version="1">MGARTASATGLILSSRTTVCSQCLRDDLRFTHIALQSRKYHPTRRRDASPFGAAVSAAQAIFKGMPKAPPGISVDPLRMVGKELKFLTKNIRQLLGSGHPALDKVAKYYTHSEGKHMRPMLVLLMSQATALDPRKHHTYADKPSPVDSSFSAPSILEDANPEMNPLVAPNAESKYDIAGDDNILPSQRRLAEITELIHTASLLHDDVIDNAVTRRANSSANLAFGNKMAVLAGDFLLGRASVALARLRDPEVTELMATVIANLVEGEFMQLKNTAQDESRPAYTDETLAYYLQKTYLKTASLISKSCRSAAVLGRSAPEVIEASYVYGRNLGLAFQLVDDMLDYTVTEAEMGKPVGADLELGLATAPLLFAWKSNPELGPLVGRKFRKEGDVQLARELVYRSDGVEQTRALAQEYADKAIAAISDFPDSDAKTGLIEMCEKTMNRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P254</accession>
    <name>A0A0G4P254_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Plus-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S004g000329</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4P254"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Related to Pol II transcription elongation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.200">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Plus-3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036128">
        <property type="entry name" value="Plus3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115:SF8">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03126">
        <property type="entry name" value="Plus-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00719">
        <property type="entry name" value="Plus3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159042">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51360">
        <property type="entry name" value="PLUS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Plus3" evidence="6">
        <location>
            <begin position="264"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="537"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="114"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="235"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="249"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="540"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="555"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL20389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="611" mass="67896" checksum="DF4A0AED0FED69AA" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P311</accession>
    <name>A0A0G4P311_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S004g000652</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P311"/>
    <dbReference type="STRING" id="1429867.A0A0G4P311"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL20711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="110" mass="12787" checksum="A44AD4F057F30A4E" modified="2015-09-16" version="1">MIKLLSGKRLSDFRGKKDVLKLLGGDKPTALEGNGDEPKYTVAYWKKGLKEYSTYYLQAVGNKRTYDYRPGARSTEVTSHQRTWRTTYVAAEDDEAWRRDPNLFVYDLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P527</accession>
    <name>A0A0G4P527_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S005g000567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P527"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL21403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="98" mass="11629" checksum="C2680D50BE1967EE" modified="2015-09-16" version="1">MGKLRVTSFVFFLEFRPNDNMQRFTSARSINPRPKWCHIYHIWSGNTEYTLPRSLLVCSPHWERSRSEKCEESDGDMINIMVDRSEPFRRNAGFPTCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5E0</accession>
    <name>A0A0G4P5E0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S006g000062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P5E0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL21522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="267" mass="30378" checksum="C88F1E625F64E056" modified="2015-09-16" version="1">MANIFRRLRRGIKSRRSASKDAYTKLAELEQELSRAINAVYDLQMRLAEHYFMLAHTTSSNPNLVIPPFQSYSHSLSDNPRTISPTEITPTSINDIWLCAYSGSLLVDAEERWQRGEPELAMELASQVINQNPFLCELDEMRCRLFIAAVQHYLCQYEDSMASLETVMQINTCYTILNNPESSIIAGITHFIKGMNLMKLERFPEAYTSLTRALHIPGYSEKAREVQKQAVVGFTCIEAAEFDHSPAASTHALLDWEDSEIENTDNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5E1</accession>
    <name>A0A0G4P5E1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Sulfite reductase [NADPH] subunit beta</fullName>
            <ecNumber evidence="6">1.8.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PCAMFM013_S006g000081</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the reduction of sulfite to sulfide, one of several activities required for the biosynthesis of L-cysteine from sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>hydrogen sulfide + 3 NADP(+) + 3 H2O = sulfite + 3 NADPH + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>siroheme</name>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Alpha(2)-beta(2). The alpha component is a flavoprotein, the beta component is a hemoprotein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.2" evidence="6"/>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4P5E1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009337">
        <property type="term" value="C:sulfite reductase complex (NADPH)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050311">
        <property type="term" value="F:sulfite reductase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004783">
        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000007">
        <property type="entry name" value="Pyruvate:ferredoxin (Flavodoxin) oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000003">
        <property type="entry name" value="Sulfite reductase [NADPH] hemoprotein beta-component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000004">
        <property type="entry name" value="Sulfite reductase [NADPH] hemoprotein beta-component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000085">
        <property type="entry name" value="Sulfite reductase [NADPH] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000051">
        <property type="entry name" value="Sulfite reductase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.480.20:FF:000012">
        <property type="entry name" value="Sulfite reductase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000016">
        <property type="entry name" value="Sulfite reductase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="entry name" value="Sulfite Reductase Hemoprotein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.480.10">
        <property type="entry name" value="Sulfite Reductase Hemoprotein,Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045169">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010029">
        <property type="entry name" value="PRK13504.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493:SF47">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="Nitrite and sulphite reductase 4Fe-4S domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="Nitrite/Sulfite reductase N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="20">
        <location>
            <begin position="782"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="211"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="239"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00057613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00063391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00067595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CRL21541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1527" mass="168008" checksum="5B3C18075DF6C17C" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5R4</accession>
    <name>A0A0G4P5R4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S006g000203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P5R4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL21663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="66" mass="7424" checksum="7B9A1BB204D89A59" modified="2015-09-16" version="1">MKGRCRVLLLRSPYHDINTPRGQSGCFFRCSDRVAKFFSPSTGMHQCLISTNFPVDHGFTSLLCKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5V5</accession>
    <name>A0A0G4P5V5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">APOBEC/CMP deaminase, zinc-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S006g000245</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P5V5"/>
    <dbReference type="STRING" id="1429867.A0A0G4P5V5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055086">
        <property type="term" value="P:nucleobase-containing small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072527">
        <property type="term" value="P:pyrimidine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01283">
        <property type="entry name" value="cytidine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050202">
        <property type="entry name" value="Cyt/Deoxycyt_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644:SF2">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL21705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="131" mass="13889" checksum="82053636771A4855" modified="2015-09-16" version="1">MDLTPEETNLIEIARTTINTIPKSDNHSVASAALSSNGQVFTGVNVFHFTGGPCAELVVLGVAASAGTPRLSHIVAVGEDGGDGVILNPCGRCRQVLHDLHPDIRTIVQKGGEVKSVTIEELLPYSYEPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7P1</accession>
    <name>A0A0G4P7P1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S007g000314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P7P1"/>
    <dbReference type="STRING" id="1429867.A0A0G4P7P1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL22333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="245" mass="27751" checksum="2A4F9E279240E452" modified="2015-09-16" version="1">MLTASSLDLERIQLILNLEHIVNDNELETVPPVSMPLQPAETLSQVDCETSPCKPETPRTLTLTLLLLARDVVLSRLPDAVRLFSIKIETTWGYGPVTWDGKKYTLTGRPDYGIWYGDRKNLAVNTVVVEAKPGEAQLSLAETLVCMGCVHKRRQKLKRKDCTIYGLVADDQVFWFLKISHDSKWSERVVVARHQDYEKVLGMLVYFFEKAAAMSPHSKESGQVYIQEGSEMAEIQDSWDMCSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7Z1</accession>
    <name>A0A0G4P7Z1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S007g000434</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P7Z1"/>
    <dbReference type="STRING" id="1429867.A0A0G4P7Z1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL22453.1"/>
        </source>
    </evidence>
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</entry>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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        <reaction evidence="6">
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            <dbReference type="ChEBI" id="CHEBI:61929"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-rhamnosidase C-terminal" evidence="1">
        <location>
            <begin position="117"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL22910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="197" mass="21709" checksum="8E7D6F9F5AB255F0" modified="2015-09-16" version="1">MLQGTGAPKYTPTTSYRNFTLTPSSPWATLDYGPEIEVKYSEQFTGLLEPFSDGPSLFVSSLANSFRVGTFNIIRTGKFGSKLLQGAFAFSLTARWNSSLERSGDIRAYQPAYAGFGLDYVNATVPTPRGNLSVSWTAKDSVVTVEIRSPVRTTGRLALTKEWAFEDGFVPKDCDKVQDVVYEIIGGVYHITHRVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PA84</accession>
    <name>A0A0G4PA84_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S009g000150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PA84"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL23210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="101" mass="11749" checksum="D450FF05524248BF" modified="2015-09-16" version="1">MSTTTETLALVFFCLLLGLTIMIIMILVKEWTEYQATQFWPKLRSTRTLDLESGLSLLEEIQELTWRVERMETDIGRKFQLAGYLAQYHDQPPSPQSSHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAD8</accession>
    <name>A0A0G4PAD8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S009g000217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CTAG/PCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PAD8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000011">
        <property type="entry name" value="Transcription factor Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015419">
        <property type="entry name" value="CTAG/Pcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283">
        <property type="entry name" value="EKC/KEOPS COMPLEX SUBUNIT PCC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283:SF5">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT LAGE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL23277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="121" mass="13302" checksum="24AE2D9B345D43B9" modified="2015-09-16" version="1">MTLTQPTNPEFPYSLTISLPLPTNRLASCALRALEVDAELSPFVRRTLTLGTPSVEAPSQPQEKKQKQDPDEAKTVLKITYIATTNRMLRVSVNGFMENLGVVLGVMAELDIDVLKAEMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAR6</accession>
    <name>A0A0G4PAR6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S009g000352</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PAR6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PAR6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL23412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="470" mass="51404" checksum="8E704B2E9FABCC2E" modified="2015-09-16" version="1">MYAIEMASFQDKVIAITGAASGMGLATAKLLASRGAMISLADINEKALEQAIQSLPNSERHMTTAIDVRNRKSVDGWIQSTVDRLGKLDGAVNMAGIITPAAPITEETDENWDFTFSVNTRGVFFCLRAELTAMKAGGSIVSATSVFGQMGAPGVSAYCASKAAVIGLSQTAAKENQHIRVNCISPGSVNTPLSAGEDPEDVKRGLQKTAQKRQAEPVEIATVIAFLLSEEASFVTGAVYNVDGDIYHGGKTKLDKGDKVSFDKPTPSQWVIGKQVNEHSYQSAERRFTSYLDAYRFLTANYSKNTPTLLAYKRGTQPTGGLIPGGHITWIVWEKAPGKSLGRPKSAFVYWDMPADERKLVHEAFLREFPSVNNIPTTVGYPGKANDIIISKIMKMGYFPEKPSPFSLICDKDTGRLYFVGFRDSMPFKANERSGKPDEAWLPNFDLASPPQKSYKWKKHYKGNMAGWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAS0</accession>
    <name>A0A0G4PAS0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S009g000357</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the tannase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PAS0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PAS0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF8">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
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        </location>
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            <end position="518"/>
        </location>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL23417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="518" mass="55746" checksum="4BCBC6F03B9C0A1C" modified="2015-09-16" version="1"> </sequence>
</entry>
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    <accession>A0A0G4PAU4</accession>
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    </protein>
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            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38792">
        <property type="entry name" value="BNR/ASP-BOX REPEAT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G06430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195190" evidence="1">
        <location>
            <begin position="21"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL23438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="385" mass="41971" checksum="94610F0458F47C39" modified="2015-09-16" version="1">MRFVVQALQILPAILSIASSQVVSNPQPEPFTDFLNYIIWHPAADAVQWHTLYARSLQLPDESLLITWENYPLEPPLVNHPIFRSVDGGSTWSNYSAVEDQVNGWGMRFQPFLYTLPEEFGGYAAGSILAAGVSAPFSLVGGVYIDLYISVDNAKTWKFLSHVAYGAGPETISNGDDAIWEPFLMLDDGKIVCFFSDQRDPAYSQKLVHVTTTDLLTWSAAVPDVVYSTQGDRPGMTTVAHIEPTDTYIMTYEYCGTAGCAVHYKIAPSPLEFNSVAGIPLVSNDTSPITPYGSPYVIWTANPNRDDGSGLIIVSSGNQEVVFVNEDAVDADGWKTVNMGMWSAYSRSLRIVTIEGAKKLLFANGGNMGDPDNNSIACGVAEIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCB5</accession>
    <name>A0A0G4PCB5_PENC3</name>
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        <submittedName>
            <fullName evidence="9">Fungal transcriptional regulatory protein, N-terminal</fullName>
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        <name evidence="9" type="ORF">PCAMFM013_S010g000389</name>
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
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                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="52"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="86"/>
            <end position="162"/>
        </location>
    </feature>
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        <location>
            <begin position="662"/>
            <end position="768"/>
        </location>
    </feature>
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        <location>
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            <end position="927"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
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        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
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            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
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            <end position="692"/>
        </location>
    </feature>
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        </location>
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        <location>
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        </location>
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        </location>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL23951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="949" mass="104831" checksum="02D99A09D87E356D" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCV7</accession>
    <name>A0A0G4PCV7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Splicing factor PWI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S011g000157</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May be involved in the turnover of nuclear polyadenylated (pA+) RNA.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="RRM1_RBM26_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CCCH zinc finger and RRM domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000647">
        <property type="entry name" value="CCCH zinc finger and RRM domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
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</entry>
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                <person name="Dupont J."/>
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</entry>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Dupont J."/>
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                <person name="Abraham A.L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
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        <property type="match status" value="1"/>
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    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3" id="KW-0813">Transport</keyword>
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            <end position="112"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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        </location>
    </feature>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="436"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
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        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="646"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="724"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL24465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="788" mass="88941" checksum="430AF85ABC552B12" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDS1</accession>
    <name>A0A0G4PDS1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-reducing end alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="4">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S012g000045</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="4"/>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PDS1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PDS1"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000092">
        <property type="entry name" value="Probable alpha-L-arabinofuranosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055235">
        <property type="entry name" value="ASD1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051563">
        <property type="entry name" value="Glycosyl_Hydrolase_51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31776">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31776:SF0">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22848">
        <property type="entry name" value="ASD1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195454" description="non-reducing end alpha-L-arabinofuranosidase" evidence="9">
        <location>
            <begin position="18"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-arabinofuranosidase C-terminal" evidence="10">
        <location>
            <begin position="458"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL24436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="635" mass="69186" checksum="BEAD696D7FDFC0D1" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PER2</accession>
    <name>A0A0G4PER2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S013g000002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL24760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PER2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PER2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL24760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="234" mass="26516" checksum="E86CA206E708CCB3" modified="2015-09-16" version="1">MIQVRPDHFISPLAYLEVGPNGKKFAAPSGIIQSLRCRYKSSPEIIYVVDDDVEDIFGHILQYLHSGDYSVLIPAADSSSHAACEDEIEIATQDLLPLKENYFASHEDIQVHSDNSIFLPHCGDGNHLCKHPKTLLVHARLYDFATRHGLDHLRNVSLNKLYWTLSEFPLDSEKADAIVELLRVANGIGTIYTLMIHYVSLHLKTFIRCSSFISFLEEDHHVSFHLFTLLCESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PEZ8</accession>
    <name>A0A0G4PEZ8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lipin, N-terminal conserved region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S013g000095</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lipin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL24852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PEZ8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PEZ8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000063">
        <property type="entry name" value="Nuclear elongation and deformation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026058">
        <property type="entry name" value="LIPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007651">
        <property type="entry name" value="Lipin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013209">
        <property type="entry name" value="LNS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031315">
        <property type="entry name" value="LNS2/PITP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057124">
        <property type="entry name" value="Ned1-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181">
        <property type="entry name" value="LIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181:SF12">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04571">
        <property type="entry name" value="Lipin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08235">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24565">
        <property type="entry name" value="Ned1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00775">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LNS2/PITP" evidence="4">
        <location>
            <begin position="442"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="96"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="645"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="732"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="654"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL24852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="770" mass="84588" checksum="9C78D6604C8354D7" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PF60</accession>
    <name>A0A0G4PF60_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S013g000222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793146">
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195285" evidence="1">
        <location>
            <begin position="21"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL24979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="52" mass="5802" checksum="2E9AD18A801C2AD3" modified="2015-09-16" version="1">MVTWSLYCGLIALIFWSALFDDSMTQSHVNLYQIADQGPPNRTPSANPDFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PFU0</accession>
    <name>A0A0G4PFU0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L44e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S014g000095</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PFU0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PFU0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.80:FF:000001">
        <property type="entry name" value="60S ribosomal protein L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_eL44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053708">
        <property type="entry name" value="Ribosomal_LSU_eL42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10369">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36A/L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01172">
        <property type="entry name" value="RIBOSOMAL_L44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL25199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="106" mass="12122" checksum="627591F33C1DC8B8" modified="2015-09-16" version="1">MVNIPKTRRTYCKSKECHKHQQHKVTQYKAGKASLFAQGKRRYDRKQSGYGGQTKPVFHKKAKTTKKVVLRLECTACKAKKQLALKRCKHFELGGDKKTKGAALVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PFX1</accession>
    <name>A0A0G4PFX1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S014g000093</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PFX1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PFX1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="14"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="682"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL25197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="736" mass="81282" checksum="7D3DE14512C9A84C" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PG21</accession>
    <name>A0A0G4PG21_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutaminase</fullName>
            <ecNumber evidence="2">3.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S014g000175</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaminase PdxT/SNO family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="2"/>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PG21"/>
    <dbReference type="STRING" id="1429867.A0A0G4PG21"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903600">
        <property type="term" value="C:glutaminase complex"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:lyase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:transferase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:pyridoxine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01749">
        <property type="entry name" value="GATase1_PB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PdxT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
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        <property type="entry name" value="PdxT/SNO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021196">
        <property type="entry name" value="PdxT/SNO_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03800">
        <property type="entry name" value="PLP_synth_Pdx2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01174">
        <property type="entry name" value="SNO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005639">
        <property type="entry name" value="Glut_amidoT_SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01236">
        <property type="entry name" value="PDXT_SNO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51130">
        <property type="entry name" value="PDXT_SNO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="55"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="149"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL25279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="267" mass="29205" checksum="5D55620A3475239D" modified="2015-09-16" version="1">MAITVGVLALQGAFFEHVQLLKKAAEQAPSSEWQFIEVRTPQELATCDGLVLPGGESTTMSLVAARSNLLEPLREFVKVDRKPTWGTCAGLILLAESANKTKKGGQELIGGLDVRVNRNHFGRQTESFQGPLDLPFLGQDAPPFPAVFIRAPIVEKILPHHKGIQTEEIQQEDVVVAPSREVRDSVAQAATAEQVEVLATLEGPAAQRATEGRDTNPDQEVGDIVAVRQGNVFGTSFHPELTGDARIHTWWLREVQAAVLRRDKLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGA1</accession>
    <name>A0A0G4PGA1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lipopolysaccharide-modifying protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S014g000232</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 90 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF35">
        <property type="entry name" value="PROTEIN O-GLUCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
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            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
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            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
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            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
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        <location>
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            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="4">
        <location>
            <begin position="688"/>
            <end position="987"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL25336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="995" mass="112200" checksum="2FFD0EB2072696E5" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGJ4</accession>
    <name>A0A0G4PGJ4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S015g000029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793148">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PGJ4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL25443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="94" mass="10396" checksum="E700A167380A22CE" modified="2015-09-16" version="1">MDDSEGYVLHVTTQFFRVDSGYAQGTLGWLQEGSGLAQGWLQEGSGKAQGRLRVGSGWAPGWLRLAQGRLRVGSWHPPVARIYSNDHMIINEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PHA7</accession>
    <name>A0A0G4PHA7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S015g000289</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793148">
        <property type="protein sequence ID" value="CRL25703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PHA7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195539" evidence="3">
        <location>
            <begin position="20"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL25703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="185" mass="20729" checksum="8942FD0CEB5F941C" modified="2015-09-16" version="1">MARKLALLFVLMHSLQILALPTPYENSIAFKSLASTNTYNNRYYFPETLPDQDELAAMLKETAMREAGFVPSSNGSPSNPKPKSKDQKMGTETELRKSPDTDMETAIGTDASGQSQPDWHITQNTKLRQFQSQSQSQSQSRLKESIVAAFASDNYPIYWPPFGFFVVSAAIMCFFTVLRGIRAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PHI3</accession>
    <name>A0A0G4PHI3_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sulfite efflux pump SSU1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S016g000009</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <text evidence="8">Sulphite efflux pump required for the secretion of sulphite as a reducing agent. In the presence of sulphite, cystine in keratin is directly cleaved to cysteine and S-sulphocysteine, and thereby, reduced proteins become accessible to hydrolysis by a variety of secreted endo- and exoproteases. Excretion of sulphite mediated by an efflux pump also represents a detoxification pathway for dermatophytes during infection of the epidermal stratum corneum, hair and nails, which are rich in cysteine.</text>
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        </subcellularLocation>
    </comment>
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    </comment>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686:SF1">
        <property type="entry name" value="SULFITE EFFLUX PUMP SSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="11">
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            <begin position="78"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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            <begin position="123"/>
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        </location>
    </feature>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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            <end position="211"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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            <end position="246"/>
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    <feature type="transmembrane region" description="Helical" evidence="11">
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            <end position="326"/>
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            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="25"/>
        </location>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        </source>
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        </location>
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        </location>
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        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 8">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="6"/>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJF2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJF2"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009361">
        <property type="term" value="C:succinate-CoA ligase complex (ADP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000005">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004230">
        <property type="entry name" value="PRK05678.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF2">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP_GDP-FORMING] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA-binding" evidence="9">
        <location>
            <begin position="36"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="6 7">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="49"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="128"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL26537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="329" mass="34365" checksum="2F3F50411DF290BC" modified="2015-09-16" version="1">MQAFRRNTLSALRNVGATQRRTQATSAYSETLNNLKINKDTRVLFQGFTGKQGTFHAEQAIAYGTNVVGGTNPKKAGTMHLDRPVFANVSDAVKETGATASAIFVPPPLAAAGIEEAIAAEMGLVVCITEGIPQHDMVRITDILKTQNKTRLIGPNCPGIIAPGQCKIGIMPGFIHKRGRVGIVSRSGTLTYEAVNQTTLAGLGQSLVVGIGGDPFSGTNFIDCLKVFLEDPETDGIIMIGEIGGSAEEDAAEFFKANNIHNKPAVSFIAGISAPPGRRMGHAGAIVSGGKGGADSKIAALTDAGVIVERSPASLGKTLLAEFVKRDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PK26</accession>
    <name>A0A0G4PK26_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S019g000197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PK26"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL26780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="233" mass="25695" checksum="5A45CB4E81D2828F" modified="2015-09-16" version="1">MARVSLPLQQAFIPSQTSPTMANNPSGGAGAIPRQVARQIRQQTQTRGRTTGRSGVSNSQNSIYRSGQYHSPIRPGMGSSRFATVQDDVQAPSEPDPMELDPMEIDTPVQEPAPTTAGAQSGENGVHNHIFYISISSRPMPTLDLDVLTAARVEVAHIQRAGLPVLQTLPERPGPHVYIRIDTHQPNRDNALTDANLRMGTMQDMIRDGFGWFSGLPYRHPHFEVKFLRGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PK88</accession>
    <name>A0A0G4PK88_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAR-17a/AIG1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S019g000012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PK88"/>
    <dbReference type="STRING" id="1429867.A0A0G4PK88"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242:SF1">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242">
        <property type="entry name" value="OS02G0130600 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL26596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="301" mass="34374" checksum="82B58139FA427110" modified="2015-09-16" version="1">MPRLSLTTLFGVDPTTDDKHHFETSWILPPAILAGLRGLISLYIFTSIFVFWGWFGTHNDHASIGHSFSYFTWLTYWGIGFYMLFATIHTAFYARTGHSVLLDRWPRAFRVLHSLLYVTITTYPFLVTVVFWVILFTPPWYKKTFTGWQNISQHGLNSVYALLEIILPATAPHPFIAIPFLILMLLLYLCVAYITHETEGWYPYSFLDVGEHGQKSKRVVGYCFGILAAILVCFLLSWALIHLRRRLTHGKIKRARRDPLCSHNAFVEPCGGEQSNEMKDVPVWGKVMGRFSSSGGNCLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKC8</accession>
    <name>A0A0G4PKC8_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-1,3-glucan synthase</fullName>
            <ecNumber evidence="2">2.4.1.183</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S019g000068</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[(1-&gt;3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19749"/>
            <dbReference type="Rhea" id="RHEA-COMP:11150"/>
            <dbReference type="Rhea" id="RHEA-COMP:11151"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28100"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.183"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.183" evidence="2"/>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4PKC8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047657">
        <property type="term" value="F:alpha-1,3-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070600">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11323">
        <property type="entry name" value="AmyAc_AGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03791">
        <property type="entry name" value="GT5_Glycogen_synthase_DULL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000058">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000073">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000052">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058659">
        <property type="entry name" value="Mok11-13/Ags1-like_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058656">
        <property type="entry name" value="Mok11-13/Ags1-like_GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058657">
        <property type="entry name" value="Mok11-13/Ags1-like_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058658">
        <property type="entry name" value="Mok11-13/Ags1-like_Ig_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058655">
        <property type="entry name" value="Mok11-14/Ags1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058654">
        <property type="entry name" value="Mok11-14/Ags1-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47182:SF2">
        <property type="entry name" value="CELL WALL ALPHA-1,3-GLUCAN SYNTHASE AGS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47182">
        <property type="entry name" value="CELL WALL ALPHA-1,3-GLUCAN SYNTHASE AGS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26127">
        <property type="entry name" value="12TM_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26122">
        <property type="entry name" value="CBM_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26108">
        <property type="entry name" value="GH_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26114">
        <property type="entry name" value="Ig_2_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26111">
        <property type="entry name" value="Ig_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195424" description="alpha-1,3-glucan synthase" evidence="9">
        <location>
            <begin position="22"/>
            <end position="2416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1068"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1991"/>
            <end position="2011"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2023"/>
            <end position="2042"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2049"/>
            <end position="2071"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2083"/>
            <end position="2103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2115"/>
            <end position="2136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2161"/>
            <end position="2183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2206"/>
            <end position="2223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2243"/>
            <end position="2263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2270"/>
            <end position="2290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2315"/>
            <end position="2335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2342"/>
            <end position="2365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2388"/>
            <end position="2408"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="10">
        <location>
            <begin position="65"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1663"/>
            <end position="1760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1810"/>
            <end position="1829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1924"/>
            <end position="1969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1663"/>
            <end position="1694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1813"/>
            <end position="1824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1950"/>
            <end position="1964"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL26651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="2416" mass="271700" checksum="42FDDCE7D2BD5920" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PLL4</accession>
    <name>A0A0G4PLL4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S020g000205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793153">
        <property type="protein sequence ID" value="CRL27046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PLL4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PLL4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40636">
        <property type="entry name" value="CSBD-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40636:SF1">
        <property type="entry name" value="CSBD-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL27046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="88" mass="8478" checksum="3A4C4FCE069619DE" modified="2015-09-16" version="1">MPIESNQDKGVTGAAKFVTSTLGNTLGGVTRTVGGVTGTAGRGIGDTITSATGSAGEPIGNALGSASSGLENGAKRVAQGTEDAGKWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PLP0</accession>
    <name>A0A0G4PLP0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Armadillo-type fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S021g000214</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MET18/MMS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793154">
        <property type="protein sequence ID" value="CRL27299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PLP0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PLP0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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    </dbReference>
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            <end position="111"/>
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        </source>
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        </source>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL27299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1095" mass="121706" checksum="EE272B5FB359377E" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMJ1</accession>
    <name>A0A0G4PMJ1_PENC3</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL27361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="107" mass="11888" checksum="933D020C64AFAED6" modified="2015-09-16" version="1">MISAVAVRHWPHDALSTEVRRVRGIFAIGPYRRTLVSKTYRLGVEGPERPTMTITGRHGIRNEATESRSATSGAVQMQPRRGGWSGACGIEDSMMELCRCDGGRWNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMS5</accession>
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    <protein>
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        </recommendedName>
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        <name evidence="12" type="ORF">PCAMFM013_S024g000010</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SRP72 family.</text>
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        <property type="protein sequence ID" value="CRL27755.1"/>
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        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Signal recognition particle subunit SRP72"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094:SF9">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="Signal recognition particle SRP72 subunit RNA-binding" evidence="11">
        <location>
            <begin position="549"/>
            <end position="595"/>
        </location>
    </feature>
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        <location>
            <begin position="549"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="569"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="593"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007676"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00018350"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR038922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL27755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="646" mass="70534" checksum="65661AAEE9C41F67" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PN59</accession>
    <name>A0A0G4PN59_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S024g000087</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793157">
        <property type="protein sequence ID" value="CRL27832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195488" evidence="9">
        <location>
            <begin position="27"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL27832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="529" mass="59792" checksum="91EB1182C5E26CCB" modified="2015-09-16" version="1"> </sequence>
</entry>
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    <accession>A0A0G4PN76</accession>
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        <submittedName>
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        </submittedName>
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            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793156">
        <property type="protein sequence ID" value="CRL27633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PN76"/>
    <dbReference type="STRING" id="1429867.A0A0G4PN76"/>
    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL27633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="143" mass="15991" checksum="79B8B672A6493837" modified="2015-09-16" version="1">MGLDMYDTHLKQIGVWAAIESRGGLDALLEDHLLSQGEQQLFCVTRAIIKGQTSDGGCQVLILDEATSSLDAQTDRRVQKVMREAFHDCTVFSVAHRLDTIIDFDRITVLDAGCLVEFDTPQNLLAREGLFKQMYSGTDRQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNB7</accession>
    <name>A0A0G4PNB7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S024g000104</name>
    </gene>
    <organism evidence="1 2">
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793157">
        <property type="protein sequence ID" value="CRL27849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PNB7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL27849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="86" mass="10496" checksum="07C81869FEB3EEF0" modified="2015-09-16" version="1">MVFKRRSKKWEVIEEWRKEEKWEWRGTAAAQSGRRVKESWDLEYGYPTQTESTLRIEPAGWQIWQLCCDPLKQGRGYPRMFEVHPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNH4</accession>
    <name>A0A0G4PNH4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S025g000040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793158">
        <property type="protein sequence ID" value="CRL27982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PNH4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PNH4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195490" evidence="2">
        <location>
            <begin position="21"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL27982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="211" mass="21628" checksum="8F0C17152A43FB55" modified="2015-09-16" version="1">MRIQQLLPLCGLLLASVAIASKLDHDDVPNRCWPVCGSVVGIAKSCDAQHERDSAEIQCICDWDAAKTQIPLCSACITQYQTDRRNHNITNNDHDDDDDDDDDDDDDNEALDLVHSCSLTTTTYNSAATTVTGTSTTTAGSNTATATDSSSTSGTNSQDSTTSVSSGSSDSAGASGSASSPTPTPGAAAGISAPGAASMAGIMGLMAFAWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNL2</accession>
    <name>A0A0G4PNL2_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EGF domain-specific O-linked N-acetylglucosamine transferase</fullName>
            <ecNumber evidence="1">2.4.1.255</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Extracellular O-linked N-acetylglucosamine transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S024g000018</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:12251"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:90838"/>
            <dbReference type="EC" id="2.4.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48908"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:12252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:90840"/>
            <dbReference type="EC" id="2.4.1.255"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.4.1.255" evidence="1"/>
    <dbReference type="EMBL" id="HG793157">
        <property type="protein sequence ID" value="CRL27763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PNL2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PNL2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049625">
        <property type="entry name" value="Glyco_transf_61_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007657">
        <property type="entry name" value="Glycosyltransferase_61"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961:SF148">
        <property type="entry name" value="EGF DOMAIN-SPECIFIC O-LINKED N-ACETYLGLUCOSAMINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04577">
        <property type="entry name" value="Glyco_transf_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 61 catalytic" evidence="12">
        <location>
            <begin position="379"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="101"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL27763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="550" mass="61524" checksum="E4EC50B25DC9FF97" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNN6</accession>
    <name>A0A0G4PNN6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATPase-like, ParA/MinD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S025g000120</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793158">
        <property type="protein sequence ID" value="CRL28062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PNN6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PNN6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001300">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor CFD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03039">
        <property type="entry name" value="NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028600">
        <property type="entry name" value="NUBP2/Cfd1_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF19">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="263"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="15"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL28062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="325" mass="34373" checksum="AB854CBCF096007D" modified="2015-09-16" version="1">MPLTGMKNVVLVLSGKGGVGKSSVTLQLALALSLQGKSVGILDIDLTGPSMPRLVGLEDAKITQAPGGWMPVPVHGAESAAEADASAPSTQPQRGSLRCMSLGFLLRDRGDAVIWRGPKKTAMIRQFLSDVFWGPTDYLLIDTPPGTSDEHIALAEQLLTLSTTDAAAAAQVGLPRLAGAVLVTTPQAVATSDVRKEANFCVKTNIPVLGVIENMSGYACPCCGEVSNLFSSGGGQVMAQELSLPFMGSVPIDVKFGELVEGKMEAGDSDEEDDEEDSPKSQPQDTPAEPDDRPLVERYRDTWSYPRFEGFAQTLINSIEGPTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNW1</accession>
    <name>A0A0G4PNW1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein AF-9 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S024g000113</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793157">
        <property type="protein sequence ID" value="CRL27858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PNW1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PNW1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16908">
        <property type="entry name" value="YEATS_Yaf9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573:SF1">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="YEATS" evidence="7">
        <location>
            <begin position="9"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="161"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL27858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="248" mass="28379" checksum="6A0ABD82136DD32F" modified="2015-09-16" version="1">MVSATGNKRVRGVSVFRPFVFGSIAHPFDPENKPPNCPPDHTHRWEIFVKGVNGEDISYWLKKVQFKLHETYAHNVRSIEQSPFEVSETGWGEFEIQIKLYFVAESNEKPQTLWHSLKLHPYGPDAEGMKERRETVISQNYEEIIFNEPVEPFYEILTGGAAGGQPGKSKGKNTKQIGNGRTADIPMSDAPGNPYSRMTERKELDRMAEATQTVEQMIKEEKERLIEREKYLAQLRESEGVPANTKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PP15</accession>
    <name>A0A0G4PP15_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polynucleotidyl transferase, ribonuclease H fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S025g000188</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793158">
        <property type="protein sequence ID" value="CRL28130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PP15"/>
    <dbReference type="STRING" id="1429867.A0A0G4PP15"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL28130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="164" mass="18249" checksum="9BA098853EBCE6BF" modified="2015-09-16" version="1">MRQLYQAYVTPIVDYADTFAEIKIELDRETARERAETATSTSDIIVYSDASGRKDHLGAAVVALNKNQEVIGSEQVQVGPMNRWSVHMAELIGIFYAISIVFKLAHQRPTDAYRDPTTTTILCDSKSALQSIQNARNRSGQQIVHTILSAATEVQARNIALRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPH9</accession>
    <name>A0A0G4PPH9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCAMFM013_S025g000171</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">GPI-anchored chitinase involved in the degradation of chitin, a component of the cell walls of fungi and exoskeletal elements of some animals (including worms and arthropods). Required to reshape the cell wall at the sites where cell wall remodeling and/or cell wall maturation actively take place such as sites of conidia formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyl hydrolase 18 family. Chitinase class III subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="HG793158">
        <property type="protein sequence ID" value="CRL28113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PPH9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PPH9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02877">
        <property type="entry name" value="GH18_hevamine_XipI_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045321">
        <property type="entry name" value="Cts1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF63">
        <property type="entry name" value="III CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="9 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 13 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="GH18" evidence="15">
        <location>
            <begin position="1"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="286"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="294"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="402"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CRL28113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="500" mass="53031" checksum="97EE666E7BFEF690" modified="2015-09-16" version="1">MARGIRNSSLWHTTATVSEVIPMAFNMMVNGPGGAPEIDFSVTSKDCDVFEGTQLKNCPSVAKDIATCQKKNKTILLSIGGATYSEGGFKSEQDAKDGAKLMWETFGPKQDGSKSLRPFGDVALDGFDFDFEANVQHMAPFANELRSLMEADNSKQKFYLTAAPQCPYPDQADKEILNGPVYIDAIWVQFYNNFCGVNNFNTDPSSSKYNFDEWDNWAKTVSKNKDVKVIIGVPAFTTAASTGYIPASELAKVIEYTKKFESFGGVMMWDATQAYGNDGFIKDVRKSLGPAHDSGSSSPDPVSTSAPASTSTDSTKPTKPTTTTTLTTSTTTTTTSSSSNAPDSSHSASSSSSATASPKGAEETTTTTTTTTTKEQKPTVTTSTTAATTSADQKPENTEAKPTLAATTSAQTTAVPTSTTAPTSTTAPTSTASPQNENSSTEDNSNDEPESNTLTSILGNDLLGLLGGLRKANKVTSDITHGLTNNLRRAQRNLSFPLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPT0</accession>
    <name>A0A0G4PPT0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">D-xylulose reductase</fullName>
            <ecNumber evidence="7">1.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Xylitol dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S026g000031</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Xylitol dehydrogenase which catalyzes the conversion of xylitol to D-xylulose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>xylitol + NAD(+) = D-xylulose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 or 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungal route): step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.9" evidence="7"/>
    <dbReference type="EMBL" id="HG793159">
        <property type="protein sequence ID" value="CRL28166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PPT0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PPT0"/>
    <dbReference type="UniPathway" id="UPA00146">
        <property type="reaction ID" value="UER00577"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046526">
        <property type="term" value="F:D-xylulose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019569">
        <property type="term" value="P:L-arabinose catabolic process to D-xylulose 5-phosphate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF3">
        <property type="entry name" value="D-XYLULOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0520">NAD</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0859">Xylose metabolism</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="19"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL28166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="369" mass="38877" checksum="8D3AD4D0E8FC5A04" modified="2015-09-16" version="1">MTVTKATQTTNEAFVLHPGGTFAFEERSVPTVQSDRDVIVRVMATGLCGSDVHYWQHGRIGPYVVENPIILGHESTGIVVESGSSVQGLAVGDRVALEPGIACNTCNHCRNGRYNLCRGMRFAATPPYDGTLATYYRVPAECCFKLPAHISLRDGTLIEPLSVAVHSCQLAGFMQDKAVVIFGAGPVGLLCCAVARAFGASTVVAVDVVPARLASAVKYGATHTYQMSTETPEKNAVDLLAAAGFPDGVDVALDATGAEPCQNCAIHALTQGGTFIQVGLGKPNPSIPVGQICDKEIVFKGSFRYGPGDFKLAVGLLNSGRVKLDDLVTHEYPFSQAEDAFKNVAGRGGIKSVIYGPNVDEAEAKATSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPW9</accession>
    <name>A0A0G4PPW9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S028g000025</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793161">
        <property type="protein sequence ID" value="CRL28472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PPW9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PPW9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000374">
        <property type="entry name" value="3-oxoacyl-(Acyl-carrier-protein) reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="19"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL28472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="293" mass="31386" checksum="B114128E3AE68E7D" modified="2015-09-16" version="1">MSVNMGSYQGTFPRIYEHKLALVTGSARSIGAAIVQNLASKGCNVIINYATEASDESAVTLAANLECEYSVRALPIRADITSREECARIVSTAKEHFTDSQTGSFQIDIIVHNAAVLYIGPLESVKESEFHRIYEVNVLGPLLLTGACKEYLPTDRSGRIVMLSSIAGTTGPENTSLYSGTKGAVEAMTRVWCRELAERATVNAINPGPVMTDMYMSASDAVKESLALWNPITPLVAVRETDRPEVKELGKKFGGRAAYAEEIAGLVATICNPEFGWCTGSVISANGGSSFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPZ7</accession>
    <name>A0A0G4PPZ7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S026g000101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793159">
        <property type="protein sequence ID" value="CRL28236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PPZ7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL28236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="55" mass="6601" checksum="1113E1E500774310" modified="2015-09-16" version="1">MKEKLKHRRRHDKLMNRQADSDLCGSLWLLYLDGFRHIVRDGRMGPDIEDLFGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQ13</accession>
    <name>A0A0G4PQ13_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S026g000116</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEN54 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793159">
        <property type="protein sequence ID" value="CRL28251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQ13"/>
    <dbReference type="STRING" id="1429867.A0A0G4PQ13"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024337">
        <property type="entry name" value="tRNA_splic_suSen54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024336">
        <property type="entry name" value="tRNA_splic_suSen54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027:SF1">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12928">
        <property type="entry name" value="tRNA_int_end_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA-splicing endonuclease subunit Sen54 N-terminal" evidence="4">
        <location>
            <begin position="74"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="98"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="429"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="442"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL28251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="453" mass="49921" checksum="5AF1EB8D77A2F669" modified="2015-09-16" version="1">MADADEDAIRAPENASTQPEVDLSDETQDFRFLNHLNFFADSSPGIPRRGEKDFEPNPTELQADVLSASRGAMHNALSYPRLHATKTRVIAFYAPDGYVPPAPTERATPKAGGEDGKSSDSTPKPARPLPNSARISPDACVYVTNPKGQFFKTMGQADSSSRVWLLPEEALYLIERGSLDIRWPSPSGSVAGPGEEDLSVPMSLQAAYACFMGRGGLTLERYSVYTGLRRLGYALVRAPGWYDDIEKPDAEASDASDITPPKLHGPGLAGMLGSLFNWIHDPRSTASTATGPIIGTGIHRHYMDVYRKLAIIPWYDPVTAPERHTSDTTPPFRVVFHIYKPSTPFKKSSPPTPDFRIAVVSTRDQTTMPTMTQLGALLESTPLDPPRGEKMDRMMYMRLRHGYRNVVMAVVDQGVVSYLRIADSAFGKEKLYENKGGPQGPKRNRANQTPRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQ19</accession>
    <name>A0A0G4PQ19_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S027g000134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793160">
        <property type="protein sequence ID" value="CRL28445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQ19"/>
    <dbReference type="STRING" id="1429867.A0A0G4PQ19"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL28445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="168" mass="18918" checksum="EEF0A100745919CD" modified="2015-09-16" version="1">MDKEVQDDLLRDVKDFLNEDTQKWYADRGIPYQRGYLLYGPPGTGKSSFRISDSKLMKLFSELPLYCIVLLEDVDAAGIGRRDDSDTDQEDKSTSGVTLSGLLNVLNALIRPGRADKKVYFQLADKKISTQLFHTVFKQTVDHKGSKHECGDEAIERLANNFASKVPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQ58</accession>
    <name>A0A0G4PQ58_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA damage-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S026g000166</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DDB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793159">
        <property type="protein sequence ID" value="CRL28301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQ58"/>
    <dbReference type="STRING" id="1429867.A0A0G4PQ58"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000678">
        <property type="entry name" value="Putative UV-damaged DNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000592">
        <property type="entry name" value="UV-damaged DNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000629">
        <property type="entry name" value="UV-damaged DNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="7">
        <location>
            <begin position="12"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="8">
        <location>
            <begin position="427"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="6">
        <location>
            <begin position="786"/>
            <end position="1110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL28301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1143" mass="125339" checksum="4263AFD54CCEFE75" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRJ7</accession>
    <name>A0A0G4PRJ7_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">S-formylglutathione hydrolase</fullName>
            <ecNumber evidence="2 7">3.1.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S032g000068</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Serine hydrolase involved in the detoxification of formaldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-formylglutathione + H2O = formate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14961"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="3.1.2.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the esterase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.12" evidence="2 7"/>
    <dbReference type="EMBL" id="HG793165">
        <property type="protein sequence ID" value="CRL29032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PRJ7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PRJ7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018738">
        <property type="term" value="F:S-formylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000002">
        <property type="entry name" value="S-formylglutathione hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014186">
        <property type="entry name" value="S-formylglutathione_hydrol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02821">
        <property type="entry name" value="fghA_ester_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061:SF0">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0719">Serine esterase</keyword>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR614186-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL29032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="285" mass="31179" checksum="D30D0270C76C0CCC" modified="2015-09-16" version="1">MSVTTNATIASFGGKLLKLSHAATTTKCEMKFNLFLPPQAQTQKVPVLIYLSGLTCTAENCSEKGFFQHSASKKGIAVLYPDTSPRGLNIQGEDDAYDFGSGAGFYVDATKAPYHAGYNMYSYVTDELPQTVFAAFPQLDASRVSITGHSMGGHGALTLFLRNPGKYKSVSAFAPITNPTNCPWGQKAFKGYFGDDQQDKWKEHDATELIKKWSGGPLDILIDVGTGDNFYKQGQLLPENFEAAARDAGIAGLNIRYQPDYDHSYYTMATFADDHVEHAAKYLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRM4</accession>
    <name>A0A0G4PRM4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase, P-type cation-transporter, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S030g000100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793163">
        <property type="protein sequence ID" value="CRL28813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PRM4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PRM4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL28813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="111" mass="13689" checksum="F6445E1D06EEA5C7" modified="2015-09-16" version="1">MVNMRRSFFRMQPKSKKYFTQWMYDVWRNKFLFWSIMAGWITMFPMIYIPVLNDVVFKHKPITWEWGIVAVEAVLFFIGVEAWKWTKRVFFRRRVRKSSMLSSSRDVPEHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRQ5</accession>
    <name>A0A0G4PRQ5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S033g000020</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Endoplasmic reticulum membrane</location>
            <topology evidence="2 10">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the OST1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793166">
        <property type="protein sequence ID" value="CRL29100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PRQ5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PRQ5"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007676">
        <property type="entry name" value="Ribophorin_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049">
        <property type="entry name" value="RIBOPHORIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04597">
        <property type="entry name" value="Ribophorin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005118205" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1" evidence="10">
        <location>
            <begin position="20"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="569"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="815"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL29100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="835" mass="93267" checksum="712F4DF899F16BBA" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PS10</accession>
    <name>A0A0G4PS10_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S034g000023</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793167">
        <property type="protein sequence ID" value="CRL29225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PS10"/>
    <dbReference type="STRING" id="1429867.A0A0G4PS10"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF2">
        <property type="entry name" value="SRPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="21"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL29225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="377" mass="41814" checksum="9C45E90C88681A1E" modified="2015-09-16" version="1">MDGFNTEAFTLLGVAIVIIGLRTTARWIMVGPKGFQADDYLMIVACVVYGLETGAAYMVGAWFMGLANNSMTDEQRKKLSPDSEEYRLRVGGSKVQVAGWSLYTLLLWLLKTCMAIFYSRLTAGLVNMRIRIHLAYVLIAVTYIATICSILFGCHPMEKNWQIDPNPGNYCQPAVSKIDIYVTVVLNVATDLYLISIPAPMLVKARLKWREKLELLVLFSGGLFVMMAGILRCVLILTAGANGAQQAGSWACRETFVAVVIGNIPMIYPLVRRFTRRAGLYISSRGGSESYPGYHLSEADTGGYSRRKKFRHPLSIPGDTQWNTISDEQMILPTSRQQPPTCTAGDGDWESHSQSSQNGIKVVHETIIHSTEKSPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PSC2</accession>
    <name>A0A0G4PSC2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S035g000034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1429867.A0A0G4PSC2"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF37">
        <property type="entry name" value="AMIDASE C869.01-RELATED"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195584" evidence="1">
        <location>
            <begin position="21"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="83"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL29339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="584" mass="62822" checksum="E03AF81E67A8EBF8" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PSH7</accession>
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        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793168">
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            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL29337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="68" mass="7770" checksum="58D22CCF16E48B8A" modified="2015-09-16" version="1">MRIWLRDPIDIESMRCRFGEFIGVPNELVDPCLPNPRLWYAGRDKPPKESSGKTPSISGVVQKVKEKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PSP2</accession>
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        </submittedName>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
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                <person name="Lacoste S."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL29392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="103" mass="11690" checksum="74CFB1DC1FD049A3" modified="2015-09-16" version="1">MFPTGAMPGAPIKIQTTPIAVLYQTEPSPVPQTLMFLQLQQNLLRSRRQAFPVRFLQTLLFSILRRCIGRRIKDALLARGSQPDIIRDTSHGPLSRWLGRPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PSQ2</accession>
    <name>A0A0G4PSQ2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PCAMFM013_S036g000083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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        </location>
    </feature>
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            <end position="62"/>
        </location>
    </feature>
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            <begin position="68"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL29499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="78" mass="9343" checksum="877D486007BEBCA8" modified="2015-09-16" version="1">MPSTKSYRSFVRRLYYYEFHRFGGAYRHETFIRGQPGSIQPTREMSHNPSFPSSLRNSTSQHGPRYMLIKRKRTRESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PTH1</accession>
    <name>A0A0G4PTH1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S035g000101</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PTH1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF285">
        <property type="entry name" value="RETINOL DEHYDROGENASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="395"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL29406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="422" mass="47227" checksum="9636C27C68CEBFAA" modified="2015-09-16" version="1">MPIPIIAQGLRDGVSSIPHAWTILRIAPWVLALAALKYYFEGARNGSERMMRSKVIMVTGGTSGIGAEVARELATRGAQVILLTRQPPSDLFLSEYIDDLRTSTKNPLIYAEQVDLSSLHSIRTFATKWIDNIPPRRLDGIILAGGIAEPSAPRTLTIDGIDQEWQTNYLANFHLLSILSPALRAQPAHRDVRVIFTTCSSYIGGNFSNLESVARGKQKVVTKRTKTSPTLYAQPKGVYALSKLALTIFAHSFQRHLNSYERPDSLPPCTRVIVVDPGLTRTPGMRRWLTGGSLWGLALYLITWPIWWLVFKSPTQGAQSILYAAMEQQYGRGGGGWLIKECREMDYARADVRNDEVGKKLWEFSGKMVEEAEKESAVMRALEKKEVKIEKQKVEDEKVKKEAAEKKGKKTEGSRRSRKGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-11-27" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PTK6</accession>
    <name>A0A0G4PTK6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proteasome component (PCI) domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S039g000057</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793172">
        <property type="protein sequence ID" value="CRL29748.1"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Proteasome regulatory particle subunit (RpnG)"/>
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    </dbReference>
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        <property type="entry name" value="Putative proteasome regulatory particle subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
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        <property type="entry name" value="RPN7_PSMD6_C"/>
    </dbReference>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="231"/>
            <end position="460"/>
        </location>
    </feature>
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        <location>
            <begin position="108"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50250"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL29748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="494" mass="54666" checksum="6EE49441B7354858" modified="2015-09-16" version="1">MGSDPQYIKFPNLSIAQHVFNLSNPACAPAVQQSSLKKLQEVILEHKMAPFYRHLAHPTEGILNNSGEGVTQHPQNGGNSTKPLITSNLLASRKTPLNFDFPWDEKLYQSLLEDNKKELETFQKEEDEAEEAAGETEVQAARGKRAEFWARVGDKDKAVESHEALLEKTGFLGTKIDLVMAMLRIGLFFGDLLFVNKTIERAETLVESGGDWDRRNRLKAYKGLHLLTIRSYSLAAPLLLDSLSTFTSYELCSYSSLVIYSVLAGSLSLKRVDFKAKVVDAPEIKAILGSGEDQLAALSGEISSGPGARDEEMKDATASLPTPAGAKTAVNISSFSTGSGVAVEAEAPVDFAPLANLVTSLYNGNYRSFFVALAAVEDQFLTQDRYLHEHRAWFVREMRLRAYQQLLQSYRVVGLSGMANDFGVTVDYLDRDLAKFISNNRIACTIDRVNGIIETNRPDDKNKQYADVVKHGDSLITKIQKYGQAVRLRGSERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PU00</accession>
    <name>A0A0G4PU00_PENC3</name>
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        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PCAMFM013_S042g000029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793175">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL29970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="564" mass="66018" checksum="37C480BC6B065DB5" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUA8</accession>
    <name>A0A0G4PUA8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">PCAMFM013_S039g000051</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793172">
        <property type="protein sequence ID" value="CRL29742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PUA8"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="125"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="743"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL29742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="807" mass="89266" checksum="F32206103067E5A5" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUN2</accession>
    <name>A0A0G4PUN2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="24">Polynucleotidyl transferase, ribonuclease H fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">PCAMFM013_S046g000044</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="18" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
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    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="24" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="17" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="23">
        <location>
            <begin position="578"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
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            <end position="1034"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1252"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="899"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="921"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="979"/>
            <end position="1034"/>
        </location>
    </feature>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
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            <dbReference type="ARBA" id="ARBA00022932"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
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            <dbReference type="ARBA" id="ARBA00048173"/>
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            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL30240.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1301" mass="147800" checksum="754C0B7C573616A2" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUQ3</accession>
    <name>A0A0G4PUQ3_PENC3</name>
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        <submittedName>
            <fullName evidence="8">Sugar/inositol transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S040g000068</name>
    </gene>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL29842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="335" mass="37740" checksum="FC037A0EA1DF9362" modified="2015-09-16" version="1">MAEMSLTEKERGPEVAFQCIFLVSGCAFAYWVDFGFTRLDNQVSWRIPLGFQAFLGAVSGVGMFLLPDTPRWYYVRGRLEEGDEVLSRLFDRPVLDSDVQTMRESILASLELESEETKTLDPVDLFWDRTNLRVGRRLRIAFLILSVQQMMGINVAVYYSVTIFAQIGLSSTLSQLLAAVMNTIFAIGSLFLPSTIERFGRRNILMYSAGGLTICLSIFVAMIGSPGPTLAKQWVAVAAIIVYNLIFGYGWIGVCWLYGPEKVGWKLWLWCLLSCAVAVPFVYFLCPETTGKTLEEIDLLFQKESEADQSNTDSLEAHSNEKMEVEHFHQETAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUS3</accession>
    <name>A0A0G4PUS3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutathione-dependent formaldehyde-activating, GFA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S041g000021</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793174">
        <property type="protein sequence ID" value="CRL29879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PUS3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PUS3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052355">
        <property type="entry name" value="CENP-V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620:SF1">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620">
        <property type="entry name" value="CENTROMERE PROTEIN V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="4">
        <location>
            <begin position="8"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="CENP-V/GFA" evidence="4">
        <location>
            <begin position="146"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL29879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="281" mass="30980" checksum="D516D515A3A0E57A" modified="2015-09-16" version="1">MMSSPEIYKGNCHCGQIRFNLDLQQPLRQVFSCPCSICAKKGYLWIFPEESQLQITSGYQSMATYTANGRSGDHFFCPTCGAGIMAKNHMIHAGKSSTAVNARALCGVNPFTLEVEALDCPSNGADVPTPFSGQVAEVPGGNLKLYTGGCYCGAATLAVKMKPWSEVEIKEDNCSICQRNANICIYPHRDSVSIHGKENTSEYLFQRRFNAHCFCRICGVHVYMKLHGPPKAVVDKLPSEKQKMVRELLAIVPIRLSVLDSVEWSDCHVKRSDEGTVGYVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVB0</accession>
    <name>A0A0G4PVB0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Ubiquitin-related modifier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">URM1</name>
        <name evidence="7" type="ORF">PCAMFM013_S044g000035</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 6">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of UBA4, then thiocarboxylated (-COSH) via the rhodanese domain of UBA4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the URM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793177">
        <property type="protein sequence ID" value="CRL30104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PVB0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PVB0"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01764">
        <property type="entry name" value="Ubl_Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03048">
        <property type="entry name" value="Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015221">
        <property type="entry name" value="Urm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14986">
        <property type="entry name" value="RURM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09138">
        <property type="entry name" value="Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037379">
        <property type="entry name" value="Ubiquitin-related_modifier_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="MoaD/ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="modified residue" description="1-thioglycine" evidence="5">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)" evidence="5">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL30104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="114" mass="12823" checksum="E2DEFDDCBB3DD67D" modified="2015-09-16" version="1">MADTSNAGQGEFPIPIIVEFTGGLELLFGNERKHKVVLPARLEDGSRPNISYLLKYLVDNLMKDQRIDMFIMEDNVRPGILVLINDADWELEGEETYELQQGDTIVFVSTLHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVU4</accession>
    <name>A0A0G4PVU4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S048g000006</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793181">
        <property type="protein sequence ID" value="CRL30294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PVU4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053230">
        <property type="entry name" value="Trans_reg_galc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="25"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="106"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="162"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="695"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="705"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL30294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="788" mass="88978" checksum="3D01EB22DC3AE99C" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PWJ9</accession>
    <name>A0A0G4PWJ9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S061g000011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793194">
        <property type="protein sequence ID" value="CRL30837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PWJ9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="110" mass="12571" checksum="7728435C1343ECD9" modified="2015-09-16" version="1">MSVHIWPSTLDKGLMETESSDHVPLPSPSQQEADIRHTLATEPFQPILKVLADLERDDPKFAFPAARLVGLHRRLWESYVSKHNDGEKLEQRNLALKEAGTYLRKERDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PXD7</accession>
    <name>A0A0G4PXD7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S070g000004</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793203">
        <property type="protein sequence ID" value="CRL31055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PXD7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PXD7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="103"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="161"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL31055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="253" mass="27935" checksum="32A818FD9B918EB4" modified="2015-09-16" version="1">MATLFCPPPRLERGYHQHFPSLQYPSPNFGQQQHPPPRYSPSQYANSRYTPLPNTASIHAHQGHASYRLPPPSRSYRPDLFSQVQAPRGTYQAAAPRQRTAVACRRCRRRKIPCSGFKTSAGGRCSNCFKYNQHCILIPATSQTQAFVPAHAAYPRLLTGPNGPAAPGPEGPGGYGGPSVLYGAHGQPLPPQHKPQDHETILLPPQWIYYQDGTTPNRWCPLQPISLDMLGMVKQPFPPSAKGKDNRCNVLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PXF8</accession>
    <name>A0A0G4PXF8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HAT dimerisation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S086g000005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793217">
        <property type="protein sequence ID" value="CRL31204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PXF8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PXF8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47611:SF1">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47611">
        <property type="entry name" value="HAT DIMERISATION DOMAIN, C-TERMINAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="2">
        <location>
            <begin position="12"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL31204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="203" mass="23234" checksum="C2E74FE05800203B" modified="2015-09-16" version="1">MLEALEAAITDEISQYLDSDTVSVRPLTFWKEHQARFPAIAALARDTLSFPATGAGVERLFNTARDICHYRRSRIKSETVEALMMFLCTTKFDMEEQEAILLKKFFSQDELKAAKEEREEKLSEIEVDPISDTEEQEDEPEDKPGDAIEVVIEDRPEDVPEERPLPTSEHGRPCSPSLPPTCTQTRASGRKRKSREDDLFEYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PXH1</accession>
    <name>A0A0G4PXH1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S075g000004</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793207">
        <property type="protein sequence ID" value="CRL31100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PXH1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PXH1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL31100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="288" mass="30910" checksum="FFD5CD45AF179FD9" modified="2015-09-16" version="1">MPPSIQDTTTGAAVAEFEAPAPAFLDTQPGPDHDWRITLKDKVIAITGANRGIGLAIAEVCLANEAAAIFSLDVFEPGEEFVALQNANPKRLSYVHCDVTSEESVNSAIDAVISARGAIHGFIANAGMTKHQPALDFSRAQLDQLFNLNVFGAYFCATTVARRFIELGIKGSIVFTASMTSYRPNRAAPSAPYGATKGAVRNMTHTLAMEWAKHGIRVNSISPGFIKTAMTYFVNQAPDWNLKMQYYGGMPRLADPKELGGAYVYLLSESASYTTGIDIPVAGIVGAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PY81</accession>
    <name>A0A0G4PY81_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S3Jg000049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793312">
        <property type="protein sequence ID" value="CRL31438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PY81"/>
    <dbReference type="STRING" id="1429867.A0A0G4PY81"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL31438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="103" mass="11707" checksum="2E5B5A220BB6874F" modified="2015-09-16" version="1">MGIWFDSLEAAEWMLDNGLLIDHPHIRRVEKCEIKKKRCFRCQGFGDLAWSCKETPRCGHCGGQYERERCPPGIRERCLECNGERPTGDLLCPTPATAPPSQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PYC3</accession>
    <name>A0A0G4PYC3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S4Jg000020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793313">
        <property type="protein sequence ID" value="CRL31498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PYC3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PYC3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL31498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="485" mass="55954" checksum="90B90458645C81C4" modified="2015-09-16" version="1">MTSRLLPSTSRNEGVTGSIDQTKADIATLRQQYTKLILWEEKCIWFDKKQPQSKIHIPFHRWQALLAIHKHLLQEHEHFFSMSQMPSARAAIRDVPYDYAMFNRMWRYGIYSPLELLHQNLPGSLGPMLHFIYHVSSTLNRFLEFDPALGVILYEQQGDVTRYHMAAQRQHRKHLAGISRYWYRKAADQNPNLPLCHSWATIGIFFDHWEGFTFQRDMAAHFVIAHRLLLENCSGGRLKGSTNDFLSLFPMHIQRPSSRNQHEVYIMSCNIASALGYGTPIYPQVADLFSKKQSSGSANESAPAMETEYLKLNQAFQEIRLTFQTLLVLLRYSNFPNAIPGIHISLAFLWRVSFHRSIMESLEATVPWQAVAGFLNSLFSHNTVFSRIQDEKFPIGEYETAPQLPEDFLIPGQVWSQFYYPNNFFKDTSGYSISIDEMDSEEVVRRHRCLWLGVQIAKVSWHHLGYDSFEGDGTGTDLSYSLVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NSV0</accession>
    <name>A0A0G4NSV0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PCAMFM013_S001g000093</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NSV0"/>
    <dbReference type="STRING" id="1429867.A0A0G4NSV0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2320:FF:000001">
        <property type="entry name" value="phenylalanine--tRNA ligase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2330:FF:000002">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000028">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040725">
        <property type="entry name" value="PheRS_DBD3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003210">
        <property type="entry name" value="PRK04172.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF40">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18553">
        <property type="entry name" value="PheRS_DBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 19" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="18">
        <location>
            <begin position="223"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="282"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CRL17133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="512" mass="57702" checksum="A6F56CEC11B22839" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NTH7</accession>
    <name>A0A0G4NTH7_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S001g000380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NTH7"/>
    <dbReference type="STRING" id="1429867.A0A0G4NTH7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF105">
        <property type="entry name" value="TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="24"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL17420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="408" mass="46092" checksum="10749FA0E6897B8D" modified="2015-09-16" version="1">MAAMVVRVFTAFGPPKVEKKNDAIRFGILGAAQIAPLALITPALSHPEVIVQAIAARDHARASAFAKKHNIPDVRTSYDEILDDPKIDAVLIPLPNSLHFEWAVRAIRAGKHVLLEKPSTSNATEAEILFSLPELSQPNAPVLLEAFHNRFHPAVHKFRSFITPADVVHVHTDSMIPGILLDKDNIGFNYKLAGGSMMMLGTYNFGVIRMVFDDDPVECLTCEPGIFGDGIHDQCDTDFKAKFRFPNGGIAEASTTMRGPLWWKPSEARVTHKEVVVDDKTLPETQEKLRTRIVTLHGFIHAFIWHRIDVKDTFVVRNKADRRPLKTWTESTSHKAYSYKEAGGEFANLPGEAWWMSYRYQLEEFVNRVKGRPTHYWVEGQDSWDQMKMIDMAYEKSGLGLRPTSEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NTL0</accession>
    <name>A0A0G4NTL0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S001g000341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NTL0"/>
    <dbReference type="STRING" id="1429867.A0A0G4NTL0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195130" evidence="1">
        <location>
            <begin position="20"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL17381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="95" mass="10172" checksum="49EC63D75B8317D6" modified="2015-09-16" version="1">MKLSSIFLTVFALVTTGLAAKTCTPSFDYCSDVLIKDKGFTEDDLKDVLKGSDLEKEDLKNVLFHCKNPGDVGHPKLCSSGCKDPATEGSHSCSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NU40</accession>
    <name>A0A0G4NU40_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Conserved oligomeric Golgi complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S001g000561</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NU40"/>
    <dbReference type="STRING" id="1429867.A0A0G4NU40"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019465">
        <property type="entry name" value="Cog5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048485">
        <property type="entry name" value="COG5_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049176">
        <property type="entry name" value="COG5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228:SF3">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20649">
        <property type="entry name" value="COG5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10392">
        <property type="entry name" value="COG5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 N-terminal" evidence="6">
        <location>
            <begin position="12"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL17601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="483" mass="52026" checksum="A74BF6B0BEADA29F" modified="2015-09-16" version="1">MAEGDPSYIDYEAFLDPDFSPSSFANTLVTSTNNATDTPLDLSTPLSRVLFDLQEIDTHIHALTTRSALPLLSHTQSQTAAADNILKESGTQIASVTQGYERLQKEFIQKWEAADEARVAAENSLATVRLARAVARCLTLGRQLESQVSEITGRGATGPTPSAGPDGAASPSTGKDGFRALERAAYTILNLREMLSATTQGEEGYGLDRVKFIRTLRGEFVIPAENMVKSRAQQTINIFSLSSNSASANGQSSMPSGYKQARDARARLATAATTLYLLSPPPKGEITAADYKPELLLSTLQGFMHTAIMTSVNSLARALTQLPTMDRTLIDTSARCQDIVALENILRNLRPPPHPLLASTTTTDESATESQTAASNKSNLLQPLLQALDTSSLPSYYWRSLASSLAPRVQEIVSRGGVSSRTLRSNRDRLRIEIKECVLRASQVSATSLLAEKGRPGTDTVVVGNWEREAAVMVSSVVGPLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NU97</accession>
    <name>A0A0G4NU97_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S001g000627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NU97"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL17667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="138" mass="15510" checksum="5289549DE6F86909" modified="2015-09-16" version="1">MGMVDQVSPKRSCIYRFVISSASLAEEYAAVDVIHNTPTSIGLHEGASLINGTYGSTYLPDSWKNTLRTTQFVYIPIEDWHWPMDMLKHVIELTNQYVADAYEVGGYYKVKRAVERGCVCREISYGSCGGLCPIFVWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NVP0</accession>
    <name>A0A0G4NVP0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">tRNA (uracil-O(2)-)-methyltransferase</fullName>
            <ecNumber evidence="3 11">2.1.1.211</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S002g000013</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>uridine(44) in tRNA(Ser) + S-adenosyl-L-methionine = 2'-O-methyluridine(44) in tRNA(Ser) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10339"/>
            <dbReference type="Rhea" id="RHEA-COMP:10340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74478"/>
            <dbReference type="EC" id="2.1.1.211"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TRM44 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.211" evidence="3 11"/>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NVP0"/>
    <dbReference type="STRING" id="1429867.A0A0G4NVP0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141101">
        <property type="term" value="F:tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011671">
        <property type="entry name" value="tRNA_uracil_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210:SF0">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07757">
        <property type="entry name" value="AdoMet_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 11" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL18143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="383" mass="42844" checksum="0817283C831B57FF" modified="2015-09-16" version="1">MERRLTSRNVSLDWVERDNQYGDTVSAHLIQNTYARLKLQYAEKLSQNWVEQLESPKQALEQLSLAACLIELWRSMYGAIPATEQYQSSRDTLPFPGFVDLACGNGILVYILLMEGYKGLGFDACRRKSWETFPAEIQECLEERIFIPRPFVDVLDLQEIGVEIHTGDFPENTFIISDHADELTVWTPIMAALSSPSSPLPFFVVPCCSRSLSGSSYRYPPPKEGRLIQKSANGNPAARKVDDAIEQNLQPASGDLRALRAIKIEEKTESGFLNSMIGSLAAKTMRIAEEIGFGVEKAWLRTPGAINMALIGGRQQVTREWLKNLGSTVSPTKRDRGDAVLKNIIEVVERECFKDGGIRVAAELWVERTKSLHQGQGTVHQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWR4</accession>
    <name>A0A0G4NWR4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM7</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MCM7</name>
        <name evidence="14" type="ORF">PCAMFM013_S002g000418</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWR4"/>
    <dbReference type="STRING" id="1429867.A0A0G4NWR4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17758">
        <property type="entry name" value="MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000004">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000288">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008050">
        <property type="entry name" value="MCM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF26">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24901">
        <property type="entry name" value="WHD_MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01663">
        <property type="entry name" value="MCMPROTEIN7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="402"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CRL18548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="812" mass="90530" checksum="80DAB446E7F10AD5" modified="2015-09-16" version="1"> </sequence>
</entry>
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    <accession>A0A0G4NWU1</accession>
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        </submittedName>
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        <name evidence="5" type="ORF">PCAMFM013_S002g000448</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
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        <property type="entry name" value="Ankyrin_rpt"/>
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    <dbReference type="PANTHER" id="PTHR24198">
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        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
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    <dbReference type="Pfam" id="PF00023">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="3"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
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            <end position="376"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
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            <end position="542"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
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            <end position="994"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="997"/>
            <end position="1022"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL18578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1065" mass="118196" checksum="11DA24B7490F7936" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NX84</accession>
    <name>A0A0G4NX84_PENC3</name>
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        <recommendedName>
            <fullName evidence="1">Protein YOP1</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">PCAMFM013_S002g000525</name>
    </gene>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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            <taxon>Ascomycota</taxon>
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            <taxon>Eurotiomycetes</taxon>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <authorList>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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                <person name="Lacoste S."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1429867.A0A0G4NX84"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF177">
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    </dbReference>
    <dbReference type="Pfam" id="PF03134">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
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            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL18655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="330" mass="36567" checksum="E9400D53C8E7C86C" modified="2015-09-16" version="1">MFGIFADLLSSVITILFPVFASYKALRSSDPSQLAPWLMYWVVLSVILLAESWTVFIIGWFPFYSWIRLGFMAYLVLPQTQGARILYQDYVDPFLTHHEREIEEMIGHTHERAKALGLQYFYQAIDLIRQKVLGLPPQRPTTPPQPGAASYAQSLLSRFNIPVAGAAGAAGAPANTNDWFSVLSAAVGTATSGKTREVRDEELSASGNLLQRQMQSMSGAEKAHFISSQRELLDHLRSTLAQEEQSTPRGGLEADDLAYGVPLRKNRSENSFEVVDDEDLGRRSERKTSSGWTSGWFNSEQDSSASSGAEFAARAVDEIARSRASGYDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXB7</accession>
    <name>A0A0G4NXB7_PENC3</name>
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        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL18763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="72" mass="8252" checksum="EFF79E6B749EA9CD" modified="2015-09-16" version="1">MRPAKSKAVNNPEPLSGRSQNTIRLRRQQISRDRSCYMGNPLPWSNFDRSGCNVCGQNLDNTYQQVVEELEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXF7</accession>
    <name>A0A0G4NXF7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S002g000595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
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                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4NXF7"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL18725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="384" mass="43807" checksum="4EB7C77BCD746301" modified="2015-09-16" version="1">MSALTETLPRTPKEWRSKMASSKMTKKTIHEADLASASKFGLDQFLLLRVLWKPYEDPAEIHKMLEIKNEKDRALELLHGYASWSTYCKSFERRGGLPEGTFAIARHYQLEVVKTRENADPRAFHTPIANRTRNRQARGTKVDFYSQTPTKVRGTLSSLSIDSNSNDETIDYEDDDDDDPETPLKPTSPMPQELASILYPPTKDEQIVNTALVVFLNALTIHFSLSLDWTLHRKSFTAAFKEAEFQARTDGYLGDSHGEPSVLIEVKPVTRSRKLQLIQIQESAQMVAWIKSDTQAAQKRRQMRLHISQDRHEVYVTVAKYNEGYLNYLNNTPSPRDDSDRSFLTMHQFGPWNTLDKSHIRDLGPILLAISLQADTDSKAGYFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXM9</accession>
    <name>A0A0G4NXM9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Carboxypeptidase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCAMFM013_S002g000609</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential release of a C-terminal arginine or lysine residue.</text>
            <dbReference type="EC" id="3.4.16.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="15"/>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NXM9"/>
    <dbReference type="STRING" id="1429867.A0A0G4NXM9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF190">
        <property type="entry name" value="PHEROMONE-PROCESSING CARBOXYPEPTIDASE KEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4 15 16" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 15" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006516134" description="Carboxypeptidase" evidence="15">
        <location>
            <begin position="23"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CRL18739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="531" mass="58413" checksum="8D4808894F645B7F" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NY04</accession>
    <name>A0A0G4NY04_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription factor jumonji/aspartyl beta-hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S002g000842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NY04"/>
    <dbReference type="STRING" id="1429867.A0A0G4NY04"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF105">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="172"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL18972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="328" mass="36239" checksum="2E050C6A83322B48" modified="2015-09-16" version="1">MKLKPWSIRVRTRLSRSSLYYNPQSSVRSFSASSPSQYRPLNILENATLDTFRQRCFLPEQPAILPRSTFQDLPARKQWFTRASSESAPNPVASLNVEYLQNHGADAFVPLELTESTSTDAVSGSGSDGETTETHSFRQFHAPLTLFLDWMRTAQTTPQSTRLYLAQCQLLDLPPVLREDFPTPELVARAGKGDVYDTNVWIGHPPTYTPLHRDPNPNLFVQLAGEKVVRLLAPADGQAVFGAVRRQLGKSGSREAAAFRGEEMMQGRERALLDEMVWGTPVSAGSDAGVGFEACLGAGDGLFIPKGWWHSIKGVGGGVTASVNWWFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NY84</accession>
    <name>A0A0G4NY84_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S002g000927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL19057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NY84"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL19057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="34" mass="3648" checksum="F66A658902D0B519" modified="2015-09-16" version="1">MNGTRDTRYRLFFNPSIATPIGPAIPSGGSIVQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYU6</accession>
    <name>A0A0G4NYU6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid/polyamine transporter I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S003g000051</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NYU6"/>
    <dbReference type="STRING" id="1429867.A0A0G4NYU6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF25">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL19260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="492" mass="52685" checksum="55A00054CD2E1437" modified="2015-09-16" version="1">MPHIRGLATLACTILGTWEGLLGTFTGPLTNGGSGGAIYAYIFGWVGCFANFMVLSELASMAPTAGGQYHWAAMLAPAKLQKFLSFITGWFAVLGWQSAFAACAFLTGKMIQGAAILGNNLYNALPWQGTLIVWGSLSLALVVNLLGGNLLPRIEAVILVVHILGFFGIIIPLTYMADHNTKEQVFLSFKNGGGFATQGLSWFVGMTSCAFAFAGGDAAVHMSEEVANASTVIPNALMISVGINGCLGFGMIIVMMFCTDADLGGTLGKATGYNFMGIFMEATNSVPGSLTMCAIVITIYVCSLMGLLAAASRQLWSFSRDRGVPGWRLWSQVSSTKQLPIFAIILTVTIAVLLSLINIGSNTAMEDIVSMAVSGIYLSYLTVSVLLFYRRIRGDISLFNDNEDDIVNVPGAKLVWGPFHCPGIIGTVINGYAIIYVSIVVFFSFWPSTMDPTVETMNWSILAIGGSVFLAIVYYVVRARHIYKGPIIEVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYV7</accession>
    <name>A0A0G4NYV7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phenylalanine/histidine ammonia-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S003g000034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the PAL/histidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NYV7"/>
    <dbReference type="STRING" id="1429867.A0A0G4NYV7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016841">
        <property type="term" value="F:ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.20">
        <property type="entry name" value="Phenylalanine ammonia-lyase 1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005922">
        <property type="entry name" value="Phe_NH3-lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023144">
        <property type="entry name" value="Phe_NH3-lyase_shielding_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01226">
        <property type="entry name" value="phe_am_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="HISTIDINE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL19243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="705" mass="76128" checksum="3F5D7DA8B909778A" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0E5</accession>
    <name>A0A0G4P0E5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S003g000583</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P0E5"/>
    <dbReference type="STRING" id="1429867.A0A0G4P0E5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL19792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="681" mass="76278" checksum="7951E3DE9D7A5AF6" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P100</accession>
    <name>A0A0G4P100_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">O-methyltransferase, COMT, eukaryota</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S003g000751</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P100"/>
    <dbReference type="STRING" id="1429867.A0A0G4P100"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF17">
        <property type="entry name" value="O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
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            <end position="382"/>
        </location>
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        <location>
            <position position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL19959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="406" mass="45402" checksum="79AC3EE2866DEDF0" modified="2015-09-16" version="1">MSATNEVNDSHVRLNDFCNVVEAVDQTSFSSDGERINALAAAYRLIGRLETPWDTVARLCMIEEPALFASLKIARDLQLFEEWHRVKEDAVCSDVELADLVGCDAFLLRRVLAHLAATNMLENPADGQYKPTAFTKALLQPVFGEWINYLYDSLIPCFHKAPEYLARTEYKNPTDPSNGIFQYTKSFTGGLFEYYDTHPEEGKSFNNVMGGVMANQAGMLDIYPLESLMGPTGDERETALLVDVGGNVGHDINKLLSKGSSLAPRLVLQDRDDVVRLAKCPPDVTVMAHDFFTPQPVKGARAYYLHGVIHDWADAEAGRILGHLRDAMTTGYSKLLIHDHVLSERNSHPQATAYDLTMMVKVSAFERTELMWRELLRSVGFNVIRIWNSPLATQSVIEAEPMNAEQ</sequence>
</entry>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
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    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="34"/>
            <end position="76"/>
        </location>
    </feature>
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        <location>
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            <end position="174"/>
        </location>
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            <end position="27"/>
        </location>
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        </location>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="512" mass="57964" checksum="64691806B00D2C1E" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P1X8</accession>
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        <alternativeName>
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        </alternativeName>
    </protein>
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    <organism evidence="10 11">
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
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    </comment>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="YdcJ_bac-like"/>
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    </dbReference>
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        <property type="entry name" value="2-OXOADIPATE DIOXYGENASE_DECARBOXYLASE"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00035013"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00035023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL20273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="543" mass="61313" checksum="70860269259DDDAA" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2U0</accession>
    <name>A0A0G4P2U0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LUC7 related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S004g000582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P2U0"/>
    <dbReference type="STRING" id="1429867.A0A0G4P2U0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40132">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40132:SF1">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL20641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="436" mass="50629" checksum="452DC869E85479C3" modified="2015-09-16" version="1">MDDDYVAQLLAKEAKESSIKYASQGMSAFMPSRPTSNAPKPNTRFLRNLIKVTDNHNTALKLKEEREARERMRQLKYASGASGALAPTSTDRSSKRSDDRSELRGSRDHRRGNREDRNHSHRKRTRSRSPSAERGRSRRHRRRNEEYGGTGERDKDRGEHRREHRDHESSRRDRRDRDKEHTRRRRERSYSRSPSRSPHRDGSTDRHRHRRQKRQSGHSTRSLSRSHSPESYKSRRSKREDASPHGSRRSRLETSTRHKQVSPLSTIASRQSEIDNESDPLEDLVGPLPPRQNEAPIRSRGRGAYKHNMSNIDAHFAPGYDPATDVHLDEDKIHSLGQESSRRPVAGLMTKDDDWDMAMEALRDRERWRNKGEERLRTAGIDEAVIDKWKNNTAFAGVDGEGKPEDVQWSKKGEGREWDRGKFVDDDGHIDIRAAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2Y2</accession>
    <name>A0A0G4P2Y2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NIPSNAP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S004g000549</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NipSnap family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P2Y2"/>
    <dbReference type="STRING" id="1429867.A0A0G4P2Y2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000004">
        <property type="entry name" value="NIPSNAP family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000037">
        <property type="entry name" value="NIPSNAP family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012577">
        <property type="entry name" value="NIPSNAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051557">
        <property type="entry name" value="NipSnap_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017">
        <property type="entry name" value="NIPSNAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017:SF17">
        <property type="entry name" value="PROTEIN NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07978">
        <property type="entry name" value="NIPSNAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIPSNAP" evidence="3">
        <location>
            <begin position="132"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="NIPSNAP" evidence="3">
        <location>
            <begin position="238"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL20608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="337" mass="39181" checksum="C11DECE10E0FD39F" modified="2015-09-16" version="1">MLGPRAARSARSATSFLRPFSSSAVAYRSPSIRDITAQSTEEYLRRQKEFRENLEQARLRREQQESQSVNASASSSSPSRDDQQQEAAAKRGPLSSLIYGTKEGQHFDKDMERSFSQVLARGKYVHSIVMHDVKPDKVDEYVDLVGQWYPRMAGTEENRVNLVGSWRTQVGDNDTFIHIWEYQRYEGYHDSLHSISEHPEFRDFDRKLKSLIKSKRTSLMQEFSFWPTTPPRRLGGLFELRSYTLHPGNLLEWETHWRRGLKARREVMEGVGAWFVQIGELNTVHHLWQFANLEERKICREQSWGVEGWAETVHKTVPLIQSMQSRILVPMPWSPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2Z9</accession>
    <name>A0A0G4P2Z9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S004g000642</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P2Z9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL20701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="114" mass="13347" checksum="DD03B42BB0540BCD" modified="2015-09-16" version="1">MHCSYPGFKHKGDKERVDRPRLIPTLNDEQLELLTQRRLRATTRSYLRRMSLRDAAHEMGYLEGLIDDTESSDIRVLRTLECIMANLLRRLIALRTEEEADAALERELWAHVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3B0</accession>
    <name>A0A0G4P3B0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S004g000739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P3B0"/>
    <dbReference type="STRING" id="1429867.A0A0G4P3B0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL20797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="328" mass="36736" checksum="F4DD3613F6B13610" modified="2015-09-16" version="1">MASHFLLTLFHQLFNIFIHSTGDGRILARVHGLIQKEPTQSNNLLLLVPIALLIILDILIRYIIGHVLISILIIETVEKQTNASEHGDKKPAPSSRQLLQTITVLYRKGGLRLLLNGIRSACTYWAMHSSVAKASSILFPSPVGYIIASVLLAEKHFFWTMRTILPRDQLHLVPEPRDWQRRKALVLPTLVYSAAETVMMHLPALFDTEQEVAITGLSYIVGYDILIAGLMLFAQLFLLFPSYIVLILVQASLLPPTCETLVFTPREQQRGRRVGEIFAVNGGPLRAQEAVHMVGVARLLWCLELHGKMCFCLFAVAAVVHSVIYSMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3D1</accession>
    <name>A0A0G4P3D1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyanate hydratase</fullName>
            <shortName evidence="3">Cyanase</shortName>
            <ecNumber evidence="3">4.2.1.104</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Cyanate hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Cyanate lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cyn1</name>
        <name evidence="5" type="ORF">PCAMFM013_S004g000730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>cyanate + hydrogencarbonate + 3 H(+) = NH4(+) + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:11120"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29195"/>
            <dbReference type="EC" id="4.2.1.104"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyanase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.104" evidence="3"/>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P3D1"/>
    <dbReference type="STRING" id="1429867.A0A0G4P3D1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008824">
        <property type="term" value="F:cyanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CYANATE HYDRATASE"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL20788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
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        </source>
    </evidence>
    <sequence length="160" mass="17967" checksum="2795C5845ABB133C" modified="2015-09-16" version="1">MSLATLDTTEHPNLPAVCTTLFRAKAARKLTFEKIGEHLGRNEVAAAAIFYGQAKASPEDIEKLADLLLIPQQPLEEQLSGFPDRGRSVEMPPKEPLIYRLYEIVQNYGYAYKAVLNEKFGDGIMSAISFSTKVEKETDEDGNNWAVITLRGKWLPFSRF</sequence>
</entry>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="75" mass="8250" checksum="C1862C352AEE7571" modified="2015-09-16" version="1">MLAGGRSECVLFDKWYIYTAPTLEGGEIQHGIFSGAKFARVEARNTSDEVLTVTHLVGSRDGLWLRAHSANNNTL</sequence>
</entry>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43885:SF1">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="237" mass="26014" checksum="43D00B5D2BCD89E1" modified="2015-09-16" version="1">MSAIACKHLRPRRFAPLGSAEGSTAPLLKGIVFDVDGTLCLPQNYMFSEMREALGIDRSIDILQHIRELPTADQPTAVAKVQAVERRAMADQKPQPGLVRLMDYLESRGLRRALCTRNFETPVQNLINNHLDGHVFLPIITRDTPNLLPKPDPAGILHIASEWGLANGENLIMVGDSIDDMTAGHMAGAATVLLLNEVNVHLKEHPHTDLCIKQLDDLVGILEEGFLGTRESDEHGA</sequence>
</entry>
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    <accession>A0A0G4P4I3</accession>
    <name>A0A0G4P4I3_PENC3</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
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            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
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                <person name="Lacoste S."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P4I3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL21235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="115" mass="12844" checksum="BFE9AF7F28EB4314" modified="2015-09-16" version="1">MGVVCGPGVASVTLASVQFTRALDPGVDNGMDSPRPWQRFQCDRTLNRKETRRGNVMYHHPTMSNPPFRARHDERSKITPGFTMFTMSDMLHMATSASTYTFPAQHGMVSPNVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P4I7</accession>
    <name>A0A0G4P4I7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S005g000361</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P4I7"/>
    <dbReference type="STRING" id="1429867.A0A0G4P4I7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL21197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="322" mass="35634" checksum="DCE989267C4A0D6A" modified="2015-09-16" version="1">MQFMFPKKHRNHKLVLWLMAGEFPITIVMLTLTGIASHNLYQTLLWQDGADNGFNSAPNEALYAAANYKPFKAPMVWSSFMTNYNLVLGVLSTFFLITKLPTHWMNLFYPPVAVVVHASLVILYIVSAVYQAGSDMSDPKHPQPGAPWYIAKSCSVAFKKSNVGYCMQAKALFAVTVIMIIYYVVILGFSIHSCFITPEEREAILEQREERRIEKEFEEEIIKSPSMIPMTPGSMPQGPGMVPRTPGVPPMAVGGNISPFAPRTLAFNRLDNGSTASDLPLRNNSGATQSQYPSPQSHEVSPESSKGSPMYFPPPPKKAAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P4W7</accession>
    <name>A0A0G4P4W7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Armadillo-type fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S005g000512</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Spindle pole body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P4W7"/>
    <dbReference type="STRING" id="1429867.A0A0G4P4W7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990498">
        <property type="term" value="C:mitotic spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099070">
        <property type="term" value="C:static microtubule bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061863">
        <property type="term" value="F:microtubule plus end polymerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030951">
        <property type="term" value="P:establishment or maintenance of microtubule cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990571">
        <property type="term" value="P:meiotic centromere clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:microtubule polymerization"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000022">
        <property type="term" value="P:mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Cytoskeleton-associated protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000282">
        <property type="entry name" value="Spindle pole body component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
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        <property type="entry name" value="Stu2_CTS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045110">
        <property type="entry name" value="XMAP215"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048491">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12609">
        <property type="entry name" value="MICROTUBULE ASSOCIATED PROTEIN XMAP215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21042">
        <property type="entry name" value="Stu2_CTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21041">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOG" evidence="5">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="5">
        <location>
            <begin position="280"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="232"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="517"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="748"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="525"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="547"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="626"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="832"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL21348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="902" mass="97544" checksum="D46AA926424FA5E4" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P560</accession>
    <name>A0A0G4P560_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-hydroxy acid dehydrogenase, FMN-dependent</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S005g000604</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P560"/>
    <dbReference type="STRING" id="1429867.A0A0G4P560"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF104">
        <property type="entry name" value="CYTOCHROME B2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="6">
        <location>
            <begin position="7"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="86"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="307"/>
            <end position="311"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="330"/>
            <end position="331"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL21440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="395" mass="43188" checksum="539F1B2D3CC9A688" modified="2015-09-16" version="1">MANNNIPHSSLCVSTTDFEKVAKNVLPEKSWVYASSSAATGLSMRANLDDWSLINFRPRILRSVDSMDTRRNILGHTSQFPFFVSAMGTLGSSHPGAEPLLVRGATRKGMHTMISTASTKPLEEIMDAHLDEQRQLNNQSPSNLSFQLYVPVDRTRAKSLIQRVKAAGYQSLWVTVDTSTLGKRTADRYLQAQENLDAGLAGNAREIHNENDFAPAFGGRQVPGSVDGGLTWEDLDWISSEWGGPLVLKGIQSVEDVKLAVQHGVQGVLLSNHGGRQIHSAPSSLMTLLEIRTYYPEAFDKLQVFVDGGLRDGADVLKALCLGATAVGVGRPYYYALAAYGAEGVERCTDIIAEELEITMKMLGVSSLDQLSPDMVNTSRLSNEMWRPVFGKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P573</accession>
    <name>A0A0G4P573_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AMP-dependent synthetase/ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S005g000616</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4P573"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.980:FF:000001">
        <property type="entry name" value="Non-ribosomal peptide synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1211"/>
            <end position="1286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL21452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1838" mass="203306" checksum="799878679028C24E" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5I1</accession>
    <name>A0A0G4P5I1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S006g000121</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P5I1"/>
    <dbReference type="STRING" id="1429867.A0A0G4P5I1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL21581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="500" mass="56523" checksum="36F9FA8A4110A319" modified="2015-09-16" version="1">MQTPSHESSLDLAPQSCQSCRSRKRKCDKALPRCSLCTKRNRSCEYWRPEPLSHSATASSPERGWYPSTLDEQADIQTIDFPTILFLDPALLQHSLLETSPTVGTTIPQDILQLLGDLDEIQLTATRFFKHIHQWMPFISKKRFYDLHLQPSFRSRPDVVLLLLALKLITTFPPAGSHSPRTALYNSTKHFYLVVEQSFSILVLQAGVLVALYELGHGIYPAAFLSIGACARYAHVLGISVSRTVPTRRVLTLVEVEERRRVWWAIVILDRFVSIGCPGRPFSTADPKLDDYLPADDAAWDQGTVKPDRFSTLSSPMTGHMSKFALLCQAARLLGQVLHHLSADFTSENDVWIQLDRTLQSMLAAALNIDCPDYDQITFVYSAIVALHTPWLSSDAVQEIHSHRSQRAKVILQQITERINANLIERQCFLGRDPEDMSPWGLYFAYRICGAHMRASSKAPHDLEVVRKLREGFMDIDVRWNVAGVYLKLLEAQEAINLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5P4</accession>
    <name>A0A0G4P5P4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S006g000139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <source>
            <dbReference type="EMBL" id="CRL21599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="129" mass="13974" checksum="7C65B51A7996BBB8" modified="2015-09-16" version="1">MKYNLCIWLCVIDDSLSLPLINSEAPVIHAMSSLALFSWPTPPASILTLESCRTVIPTASEHGVCEIPSQGVLILTIYLWSQDQSWAFSTVDTMMGPQCRGMRAADLSLTGAIAVIPGTRREHSKTAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P618</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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            <end position="228"/>
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        </location>
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            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="228" mass="23245" checksum="E650D4CC39F7F1DE" modified="2015-09-16" version="1">MSSYFSSLTTSSAISGLGSRLTNLRRAITLGDEGDDPDNEDCSHISNALRAYYTEKGRPFPPWLPQDPKGPAPAPSRPIATSQLPSGGYNQGSANPNSGRSGGLGDLWGDSPSSQGSIPQTASLRRGRGGTAPPLASANSAPPGPAITLSQSHSPAGSGSPSPSGARPLPSQRAGSSQSAQTRPNLDRVGSGGGSAQDRLRARLQGGRSPSPNVDPSIRKPVGMSGRR</sequence>
</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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                <person name="Abraham A.L."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Mitochondr_Som1"/>
    </dbReference>
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        <property type="entry name" value="Mitochondr_Som1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL22436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="104" mass="11689" checksum="37928721E630BEBB" modified="2015-09-16" version="1">MAPLVPIFSADSLPDHVNTVRRNFQEKRRKGEQVNLKDCPLLEMTQFSCNPPQNGVPEPGVVVCEPVVRLFRRCAGGLMVETTSWEPIRLAEEAKQKQSANTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7Z5</accession>
    <name>A0A0G4P7Z5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Tumour susceptibility gene 101</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S007g000411</name>
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    <organism evidence="11 12">
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
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    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Conseiller E."/>
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                <person name="Malagnac F."/>
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                <person name="Lacoste S."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        </subcellularLocation>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:establishment of protein localization to vacuole"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
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    </dbReference>
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        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
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        <property type="entry name" value="SB_dom"/>
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        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
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        <property type="entry name" value="TUMOR SUPPRESSOR PROTEIN 101"/>
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    </dbReference>
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        <property type="entry name" value="TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0967">Endosome</keyword>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="13"/>
            <end position="158"/>
        </location>
    </feature>
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        <location>
            <begin position="520"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="154"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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            <begin position="183"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
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        </location>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009594"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51312"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL22430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="589" mass="63619" checksum="778A3A6B6B35AD04" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P893</accession>
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    <protein>
        <submittedName>
            <fullName evidence="4">DENN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S007g000498</name>
    </gene>
    <organism evidence="4 5">
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        <lineage>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
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        </source>
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    <dbReference type="PANTHER" id="PTHR12296:SF31">
        <property type="entry name" value="DENN (AEX-3) DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11200)"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <location>
            <begin position="84"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
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        <location>
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            <end position="926"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="526"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="856"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL22517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="926" mass="104924" checksum="96B524DA14645603" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P9G7</accession>
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        </recommendedName>
    </protein>
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        <name evidence="16" type="ORF">PCAMFM013_S008g000381</name>
    </gene>
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            <taxon>Pezizomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM 013</strain>
        </source>
    </reference>
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        <text evidence="1 11">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
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        <text evidence="11">Component of the NDC80 complex.</text>
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            <location evidence="11">Centromere</location>
            <location evidence="11">Kinetochore</location>
        </subcellularLocation>
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            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the NDC80/HEC1 family.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
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            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Kinetochore protein NDC80 loop region" evidence="15">
        <location>
            <begin position="455"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
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        </location>
    </feature>
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    </feature>
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        <location>
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        <location>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF24487"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL22952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="733" mass="83402" checksum="8F62F4FDD12529E9" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P9I8</accession>
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        <submittedName>
            <fullName evidence="9">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
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        <name evidence="9" type="ORF">PCAMFM013_S008g000373</name>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="89"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="168"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="768"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL22944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="862" mass="97394" checksum="32D135A566B7E319" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P9Z0</accession>
    <name>A0A0G4P9Z0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alcohol dehydrogenase superfamily, zinc-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S009g000076</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P9Z0"/>
    <dbReference type="STRING" id="1429867.A0A0G4P9Z0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF1">
        <property type="entry name" value="ENOYL REDUCTASE (ER) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="25"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL23136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="367" mass="39023" checksum="267F5220D6316F7F" modified="2015-09-16" version="1">MSTNTETLEFDIPALCKAGVVVDEGPDFRVEVQMVPVPEPGPDDILIRLNFTGLCSSDIHMMKGDLGVPPMSTFGVRSPGHEGARIVVKAGANVKNFKLGDRAGIKPITDTCGSCAMCWDDKETYCKTAIHTGLMTPGTYQQYIVSPARYASPIPDGVPDEVAAPIMCSASTMYRSLVESNLRVGSWVVFPGGGGGVGIQGVQLAKAMGMRPIVVDTGDSKRELSIRMGAEAFIDFKDTEDPVKSVIETADGVGVHGVFVTAPAAYKNAVSYVGQRIGAVVMCIGMPPAGSTILGADPCEFVFKNLSIKGSLVGTRSDTAAALDFAKRGMLQQVSEVYPINRLPEGVEKLRKGQVAGRIVVNFNWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAI1</accession>
    <name>A0A0G4PAI1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S009g000250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PAI1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL23310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="271" mass="30877" checksum="0B1F39ABA9C99AE9" modified="2015-09-16" version="1">MPEMEARPVLPKMIGEKITTRCPNPDSALYPRRDWFVIEKLSERPSPATVEDFDDGMGPAYTVGKYLCRLAGTGNEKKLAFMRIYKQIPLAGTELDSSSVRKAQASNLHDYGHVELDALKHLTESGCTATPRLLGYQIGKQDANDLVPGGYILHLVWEKVPGDPLDIDEFWSLPYDKREFIRDKFKKAYMEVLKLGYQPILASPSKIILDKTTGDIKISGFRRAARIDPDPQWKDYNFVMFLLVLNSTARDKYHPVMAEDIKHAESNGWRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAW6</accession>
    <name>A0A0G4PAW6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sugar/inositol transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S009g000380</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PAW6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PAW6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF51">
        <property type="entry name" value="ALPHA-GLUCOSIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="159"/>
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    </feature>
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        <location>
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            <end position="252"/>
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        <location>
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        <location>
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    </feature>
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        <location>
            <begin position="66"/>
            <end position="504"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL23440.1"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="534" mass="58352" checksum="C459838BF5479894" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
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                <person name="Lacoste S."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195397" evidence="1">
        <location>
            <begin position="24"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL23591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="255" mass="25981" checksum="AC012463C899BCC8" modified="2015-09-16" version="1">MRASRWIWIAATFLTSTVHSTETAPFTPAEKATANKRAFEVLRILRRDDNNCPSGFNPCTELGNSNACCKQGTNCSRDDANNIACCASGASCTGSLTGTTTTGTGTAFMFPSGATATTTESGAASVTGSTLDAAYPFVVVPTTFSNAETCSSYYSVCQSEYTQCTGNLMGRYGVTIGAAGGGKTVQAVTAASQATSICSSLSAEACHGINLAYCSSVATQTGSADANGNDASPARMSSLHDLVFGLAVGVAGMFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Dupont J."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4"/>
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        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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            <end position="571"/>
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            <end position="605"/>
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            <end position="213"/>
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        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
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        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
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        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
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        <location>
            <begin position="993"/>
            <end position="1004"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
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            <end position="1029"/>
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        <location>
            <begin position="1099"/>
            <end position="1109"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL23734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1115" mass="121819" checksum="13E0C8FEEB96E714" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PC32</accession>
    <name>A0A0G4PC32_PENC3</name>
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        <submittedName>
            <fullName evidence="8">Ribosomal protein L5</fullName>
        </submittedName>
    </protein>
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    </gene>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CRL23824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PC32"/>
    <dbReference type="STRING" id="1429867.A0A0G4PC32"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1440.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_uL5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057266">
        <property type="entry name" value="Ribosomal_uL5_euk/arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_uL5_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003258">
        <property type="entry name" value="PRK04219.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 N-terminal" evidence="6">
        <location>
            <begin position="10"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="7">
        <location>
            <begin position="67"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL23824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="175" mass="19889" checksum="B4EF0228B1871414" modified="2015-09-16" version="1">MSAQVAKAENPCRSLRLSKLVLNISVGESGDRLTRAAKVLEQLSGQTPVYSKARYTVRTFGIRRNEKISVHVTIRGAKAEEILERGLKVKEYELRKRNFSETGNFGFGISEHIDLGIKYDPGIGIYGMDFFVCMDRPGARVAKRRRCQSKIGVNHRITTSETMKWYKTKYDGIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCS4</accession>
    <name>A0A0G4PCS4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S011g000102</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. COT1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PCS4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PCS4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000086">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000229">
        <property type="entry name" value="Serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000192">
        <property type="entry name" value="Serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF76">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_135, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="260"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="571"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="69"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="128"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="69"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CRL24108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="645" mass="73711" checksum="48EB275D195FD407" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCV4</accession>
    <name>A0A0G4PCV4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Formamidopyrimidine-DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S011g000116</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine.</text>
            <dbReference type="EC" id="3.2.2.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPG family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PCV4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PCV4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008534">
        <property type="term" value="F:oxidized purine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08972">
        <property type="entry name" value="PF_Nei_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000009">
        <property type="entry name" value="Formamidopyrimidine-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.190.10:FF:000004">
        <property type="entry name" value="Putative Formamidopyrimidine-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="entry name" value="MutM-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="FPG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="H2TH_FPG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993">
        <property type="entry name" value="FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993:SF9">
        <property type="entry name" value="FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="N-terminal domain of MutM-like DNA repair proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formamidopyrimidine-DNA glycosylase catalytic" evidence="11">
        <location>
            <begin position="2"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="299"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL24122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="370" mass="41783" checksum="51421F95F32014D8" modified="2015-09-16" version="1">MPELAEIHRIVHFIREHLVGKTLSKVQAQHDDIIFGKVGTSAAEFQKAMQGKKVVGTGQQGKYFWITMSSPPHAVMHFGMAGWLKIKDADTYYYRTDKPADQEWPPKYWKFLLETSDEPKTEAAFVDARRLGRIRLVDCPADEIRNHTPLKENGPDPVTDKDIVNQAWLTEKLGKKKVPIKALLLDQANISGIGNWMGDEILYHAKIHPEQYSNTLNDDQIKALHSAIHYVCSTSIGVLADSEKFPEHWLFKHRWGKGKKNQPAVLPNGDKITFLTVGGRTSAVVPTVQKKTGPVAKDIDEDVAKSTPANSKRKRVALKKESDSEAEETTQTKKRETPKQKKPTVKSEYFEEEKPKPAVVGRRRSTRTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCZ4</accession>
    <name>A0A0G4PCZ4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S011g000190</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PCZ4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PCZ4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000033">
        <property type="term" value="F:alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392:SF1">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL24196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="636" mass="71976" checksum="3131AB66AFA5B28B" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PE24</accession>
    <name>A0A0G4PE24_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S012g000108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PE24"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL24499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="82" mass="8924" checksum="FC8203E5679467DC" modified="2015-09-16" version="1">MAFGKVGFRQPAVQLLQHGSRVLVHCHGRTSIRDSWATSVVGDKTVVNKVTGDNKKTWKKLSSIVDPMSGLNGFMELNGNGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PEA8</accession>
    <name>A0A0G4PEA8_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Obg-like ATPase homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S012g000285</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PEA8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PEA8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.300:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="entry name" value="TGS-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00092">
        <property type="entry name" value="redox-regulated ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF7">
        <property type="entry name" value="OBG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="24"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="5">
        <location>
            <begin position="309"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00068719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL24675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="404" mass="44943" checksum="9E548BE48E2E7C23" modified="2015-09-16" version="1">MPPKKAVEAPTNNVVAFGRVKSNLKMGCVGLPNVGKSSLFNLMTEQSAAAENYPFCTIEPNEARCVVPDPRYDFLCKVWNPPSKYPAYLQVTDIAGLIKGASEGAGLGNAFLSHIQAVDGMYHVVRAFDNDEVLHVDDSVDPVRDLDTIQSELCKKDLDILAKAKVAEEAIVRKAGGKFKMLPLFDETTAKIKALLEQDKPVRDGEWTTPEIELINEKLRLITTKPVIYLINLTMKDYLRQKCKYLPKIAEWVKAHGGQGTDIIPFSVEFEEKLWSLRDDKAALDAFVADIKVPSRLGKITTEGFTKLGLQYYFTAGEKEIRCWPIKQGTLAPQAAGVIHGDFERGFIKAEVVAYKDFHDLCNGEKSMGPIKSAGKYRQEGKSYVVQDGDIVHFQFNVAPPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PEE5</accession>
    <name>A0A0G4PEE5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Protein phosphatase PP2A regulatory subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S012g000317</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Phosphatase 2A affects a variety of biological processes in the cell such as transcription, cell cycle progression and cellular morphogenesis, and provides an initial identification of critical substrates for this phosphatase. The regulatory subunit may direct the catalytic subunit to distinct, albeit overlapping, subsets of substrates.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PEE5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Protein phosphatase PP2A regulatory subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein phosphatase PP2A regulatory subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
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        <property type="entry name" value="PP2A_PR55_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037309">
        <property type="entry name" value="PP2A_PR55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00600">
        <property type="entry name" value="PP2APR55"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PR55_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01025">
        <property type="entry name" value="PR55_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="403"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="419"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00067298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU331113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL24707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="472" mass="53456" checksum="8C967597BD189246" modified="2015-09-16" version="1">MVDRDPGTPTWKFTQCFGDKGDVEDITEADIISTVEFDHTGNYLATGDKGGRVVLFERNETKKTCEYKFHTEFQSHEPEFDYLKSLEIEEKINKIKWCRRQNASHFLLSTNDKTIKLWKVFDKSLKVVAENNLSNELTPANPVGGGGMARAPRVSFKDPSALKLPRLTHHDTVVAAVPRRTYANAHAYHINSISVNSDGETFISSDDLRVNLWNLNIQDQSFNIVDIKPANMEELTEVITAAEFHPVSCNWFMYASSKGTIKLADMRQRALCDEHAKQFEQEEDASSRSFFSEIISSISDVRFSNDGRYIVSRDYLTVKIWDVNMERQPIKTIPIHEHLRPRLCDTYENDSIFDKFEVVFSGDAENVMTGSYNNNFMIYPTQEEKDTEIVLQADKSAFKAKKVGVPTPMSKGNGKKAGSRSGSPAGPGSRMKKETDADQIDFNKKILHMSWHPFEDSIAIAATNNLFVFSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PEJ6</accession>
    <name>A0A0G4PEJ6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Argonaute/Dicer protein, PAZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S012g000357</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PEJ6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PEJ6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="2">
        <location>
            <begin position="711"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL24747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1071" mass="117001" checksum="AA15C7076718F36A" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGP8</accession>
    <name>A0A0G4PGP8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S015g000115</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793148">
        <property type="protein sequence ID" value="CRL25529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PGP8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PGP8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF62">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="65"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL25529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="496" mass="54181" checksum="2F012381C2994D29" modified="2015-09-16" version="1">MAIFSKSMKPSSTPTVEDKESNNAHVEDVDSLKVADEKAQGDYSGATAKIDPAEIRLVRKLDFRIMPILWAMYFLNYIDRNAIANARLNDLEKDLGLVGTQYNTCISILFVGYLLMQIPSNMLMSSKKFRPSLYMSGCMALWAIVSACTALTKSYIGLLLVRFFLGVTEAPFYPGALFLLSVFYTRKEIALRISILYTGNIVATAVAGLIAAATFATLDQHMNLKGWQWLFIIEGAVTFGIAGLGVFMLPDHPLTTKWLTPEERQLAHDRIRRDTVGSDESKGALAGLKQAMADPRVYLLAFMQNMHLSACGFNNFFPTVVGSLGFSSTITLVLTCPPYVFSGICCIIIGITSGRYNERTWHITLSMGVAVVGFIISCVTLNKGARYVACFLFASGAYAVNSVILGWVSATLGQTPEKKAASIGFINVVANASYIYTAYLYPKSDGPRYLTGMSANTAFGIATIGSAWALRWWLQNTNKRISSGGIPGAGDVLYAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PH75</accession>
    <name>A0A0G4PH75_PENC3</name>
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        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S015g000259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793148">
        <property type="protein sequence ID" value="CRL25673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
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        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="2">
        <location>
            <begin position="151"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="437"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL25673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="470" mass="51584" checksum="EC403E146BA0D166" modified="2015-09-16" version="1">MSNASASGSTLPSGSSSELVRSSTVVRVNDENFNIPSPQRKIIMRQLRKALLEQPVPSPLWAVLHVCDIEKLGMVLQLAQFSLKIMDSFAEVSCTLPFKWTVTPSPSQLASPYPPSSFSTPPGFSPSSSSPRPHAPPVAIYAARERDGFKCVITGTRKIYQTTPIFPASALASSLKDDSTSPNIWRFADVFWGKGKTERWRRAVFNDPTQPGKPVSDCTNLICLRRDIRSAWSSGLFALRPVWVSEDNTEMEIEFYWQPKPDHRLYDMLDVSKQPVSSKNVSSVDRLIVVVGNRGESSYHAIESGYKFRMTTNDPIERPLPSFDLLDMQWHFTRMVSFCGAGSFFDEEEREDASDAKSDVTTQQDRPSTPPNKATPPNEDVLAWVESFSVASDPDSPPGSEFVEDINAVMVGPLPGPSTNRSRSVSQSSKSSEKTAELCSACSASMESSSSVTGVVSGTGNLSIDSKRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PHS2</accession>
    <name>A0A0G4PHS2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S016g000198</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PHS2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF30">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04702)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="414"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL25917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="530" mass="58599" checksum="0C9367BCA4FD74E8" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PIE5</accession>
    <name>A0A0G4PIE5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerases I, II, and III subunit RPABC3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S016g000254</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the eukaryotic RPB8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793149">
        <property type="protein sequence ID" value="CRL25973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PIE5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PIE5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000191">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005570">
        <property type="entry name" value="RPABC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03870">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000779">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00658">
        <property type="entry name" value="RPOL8c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL25973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="143" mass="15983" checksum="032B9BD60B1A0B0A" modified="2015-09-16" version="1">MSDPLLFEDTFTITSINAQKYDRVSRLTCTSNDASLTFTLDVNTELYPCAVGESLSLALASTLSLDGKEDTRASWREVSMGDQTLADDYDYVCHGKVYRFEEGATKDTMAVFVSFGGLLLYLEGPYKKLAPLRIDHVYLLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PIQ9</accession>
    <name>A0A0G4PIQ9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L10e/L16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S017g000212</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793150">
        <property type="protein sequence ID" value="CRL26229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PIQ9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PIQ9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.10:FF:000003">
        <property type="entry name" value="54S ribosomal protein L16, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_uL16_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_uL16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220:SF13">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="200"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL26229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="230" mass="25368" checksum="9CF28CC24F39F617" modified="2015-09-16" version="1">MGPQIKMFAGPLSACTRPTLSGPLATFSLSRCFSTTSPALDWLTPKFQEKSKSPKGRPHVATGGSTRGTTVVWGDFGLRMKDHDRRMPASALKIAEETIKRRLRGMNYKLYKRVSANIGVYTKGNEQRMGKGKGKFDYWTVRLPVSRIVFELKGDVHEKIAREAFRLAGHKLPGLWEFVNKDDPPVVGITKLGNGVTLDSLKRARRNPPLGTNDLASPPKSSSSSSEPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PIS1</accession>
    <name>A0A0G4PIS1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S017g000066</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793150">
        <property type="protein sequence ID" value="CRL26083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PIS1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF16">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="84"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
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            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL26637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="450" mass="49697" checksum="89B5214BBF32F346" modified="2015-09-16" version="1">MKSTKLTITLKVKWYRSTFYNAFILGLCNFLAPGIWGAMNSLGGGGEEKPYLVNAANALTFGLMVVSCFFSSVIVRFIGIKWTLIVGTMGFAPYAAGLYTNNRFGKEWLVILGAALCGMSAGIFWMAEAAIALSYPEPYNQGRFLGFWLSFRVGGQILGGVISLGINAHRSTSGSISYTVYLIFIALQALGPFAGLLLNNPSQVQRKDGVPVQLQVTNSIGYELKSMSKLWISRKFLYIVPLICQAVYTEAVMFSYEGLWFTVRARALGSFLSGAIALIIGNLLGAFLDSKRISLKRRSRYAFFLVVGWQGMCWIWASVVTTEFNKTQPTYDWNDPGFGRAFALFLFWVASFQLNYMYLFFLVGNLADDHEEVVRIAGLLRGTESAAQCVSYGLSSVSIMAAVGSVYLNFGLWAIAIFPAWLIVKEVGEAFGDKKIARETPGLREAEDHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJV7</accession>
    <name>A0A0G4PJV7_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rrp15p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S018g000144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP15 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJV7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJV7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012459">
        <property type="entry name" value="Rrp15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245:SF14">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07890">
        <property type="entry name" value="Rrp15p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL26451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="33187" checksum="2ADBF21B8834CFC2" modified="2015-09-16" version="1">MPPTFSKKRKVLDGLKGNTGRKKKFVKQRFYHSSSEDEEEDGNFNPVSLEDSDAEEGGVTVKKPSALDLRMKKAKTQKEAPAPEPKKSDASASDSDSNVGEEIELDDEDLENHDDESDASGSDEDDLSDSSPAGKATGANRGRAVPKRNDPTAFSTSISKILSTKLPTSARADPVLSRSSYAAKLVNDAADEKLDNAARAKMRAEKKEEMDRGRIRDVMGIKRGIAGPVAEEEKRVRKMAQRGVVKLFNAVRAAQVRGEEAAKDERKKGTIGMGEREKAANEVSKQGFLELINGKKGKPLNIEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJX4</accession>
    <name>A0A0G4PJX4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S019g000147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJX4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJX4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050466">
        <property type="entry name" value="Carboxylest/Gibb_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024:SF242">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024">
        <property type="entry name" value="ARYLACETAMIDE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195606" evidence="1">
        <location>
            <begin position="21"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="65"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL26730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="297" mass="33054" checksum="DA4A5E91C5F2BBD7" modified="2015-09-16" version="1">MSLLSSITLRIAAFLLRAWARFQGRITSHPDEIIFIQSREHGRSIKVHIYRPPVIETLKTPSPVLLNFHGSGFVIPAHGSDDEFCRQMSQQTGYTVLDVQYRLSPEHPFPAALNDTEDAIKWVLGQPKTFDISKVAISGFSAGATLALAVSSSCIFPPETFSSVLAFYPAVKAFVDPDVVAAPDPNGQPIPAFMLRFFARCYILPGYDPEDPRISPGYAEVDCFPRRVLIVTAGYDSLALEGESLAARLRRQSGRIVVSERMERCNHAWDKMAKKGTFEWEAKEKAYELAVNMLTCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PK94</accession>
    <name>A0A0G4PK94_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-lactamase-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S019g000022</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-A beta-lactamase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PK94"/>
    <dbReference type="STRING" id="1429867.A0A0G4PK94"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF17">
        <property type="entry name" value="(LOVD), PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="3"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL26606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="399" mass="42912" checksum="F09DB37E5F03D535" modified="2015-09-16" version="1">MDASFQSAIDAGKINGAVVCATDAEGHFVYNKASGERTLLSGEKKPQQLDDVLYTASATKLFTTIAALQCVEDGLLTLHGDLSSIAPELAAKHVLTGFADDGSPQLDPPARPITLEMLLTHTSGTTYFFLNPMIAKWRAQLGNSENKDPRPVEDLFNYPLSFQPGTGWMYGPGLDWAGRIVERVTGGTLSEFMQKRIFDPLGISDAQFYPVTREDLRARLVDLNPSDPGALGSAVLGGGGDMNLRGRGDFGGHGLFLPGLDFVKVLRSLLANDGKLLNAATVDNMFQQHLGPEAAASHKAALAGPIGPSFRVGTDLESKVGHGLGGLLTLEDVDGWYGERTLTWGGGLTLAWFIDRKNNLCGVGAIQAALPVDGDLMAELKQTFRRDIYTKYTAWKDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKA5</accession>
    <name>A0A0G4PKA5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S019g000226</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKA5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PKA5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DBAG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="53"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL26809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="592" mass="64941" checksum="99D2C654F2CE1CC0" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKB5</accession>
    <name>A0A0G4PKB5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ppx/GppA phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S019g000247</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKB5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Retrograde regulation protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000191">
        <property type="entry name" value="Retrograde regulation protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050273">
        <property type="entry name" value="GppA/Ppx_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057512">
        <property type="entry name" value="RTG2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30005">
        <property type="entry name" value="EXOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30005:SF0">
        <property type="entry name" value="RETROGRADE REGULATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23566">
        <property type="entry name" value="RTG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx/GppA phosphatase N-terminal" evidence="1">
        <location>
            <begin position="51"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="RTG2 C-terminal" evidence="2">
        <location>
            <begin position="368"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL26830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="595" mass="65012" checksum="26DFE393B4EE54FF" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKK7</accession>
    <name>A0A0G4PKK7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S020g000099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793153">
        <property type="protein sequence ID" value="CRL26940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKK7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PKK7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="533"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL26940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="591" mass="69573" checksum="5E7E8B9A643C281D" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKU2</accession>
    <name>A0A0G4PKU2_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translationally-controlled tumor protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S019g000215</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the TCTP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKU2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PKU2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034737">
        <property type="entry name" value="TCTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018103">
        <property type="entry name" value="Translation_control_tumour_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018105">
        <property type="entry name" value="Translational_control_tumour_p"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991">
        <property type="entry name" value="TRANSLATIONALLY CONTROLLED TUMOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991:SF0">
        <property type="entry name" value="TRANSLATIONALLY-CONTROLLED TUMOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00838">
        <property type="entry name" value="TCTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01653">
        <property type="entry name" value="TCTPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01002">
        <property type="entry name" value="TCTP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51797">
        <property type="entry name" value="TCTP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TCTP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL26798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="184" mass="20739" checksum="DD164A04C81D4100" modified="2015-09-16" version="1">MLIYTDIVSGDEIVADTFNLVPNKDFDILWECDCRKYLKRANEDFQLEGANPSAEDAEDEGGEGEATMVHDIEDQFRLVWLKVEDGAKPSKESYKTHIKSYLKKLHKNAAPKFAEATDAAEAEKEWKTKAAGAMKKILANWDNYDVLMGQSMDGDAMHVLIDFREDGVTPYATVWADGLKEIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKV3</accession>
    <name>A0A0G4PKV3_PENC3</name>
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        <submittedName>
            <fullName evidence="4">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S019g000225</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="entry name" value="DUF7702"/>
    </dbReference>
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        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109">
        <property type="entry name" value="UNPLACED GENOMIC SCAFFOLD UM_SCAF_CONTIG_1.265, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24800">
        <property type="entry name" value="DUF7702"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7702" evidence="3">
        <location>
            <begin position="6"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7702" evidence="3">
        <location>
            <begin position="122"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="280"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL26808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="335" mass="36718" checksum="4B73D2B0B30BBD26" modified="2015-09-16" version="1">MAVVTAEHVAIAELIIYIPTALLTIWVVLRHGFHKQLGWIYLSIFSGIRVGGAVMEILSTKNPNNANDKEWAVILQSVGLSPLLLSTLGLLKRVFDETSQHVPSSPDSKGNILLQGFASSGIAGKLMKIYSKRATATSRRSKTVQLLHLPALIALILAISGGTDQASSNISDHASGKTKTRVAVILFLAIYVAACTLWAITVRDIGLMIPSQNRIFFCVLIALPFIAIRILYSLISDFGDNHQFSLVDGDARIQLVMATLEEFVVVLMYTILGVITPKSVSNSGMTDSRQQETYHATEDTENGRPHRHANRPPYDGVTYAQAAAQEAYNQQYVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKV5</accession>
    <name>A0A0G4PKV5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S020g000196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793153">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKV5"/>
    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="412"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL27037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="485" mass="54863" checksum="7B4A28115DFB869C" modified="2015-09-16" version="1">MPRYAPPSEASSYEIGYNTVGHNDYRDDDDCIFPAFPARSKTKWVRPTTTGLIWFAIVAFGSYLAIAVVVTVLFAVNTDNKGVHQGTAEYALYKNTMFKDCYANPAPDNANNCTIINSYLKKNMPDLASEGISYLYKLEYYDESLPDSQRISYSWCQIAGCFNDYKVVPSTPRSTAFWATTIGASTEVYMILLAALWQLLKLHKAKYTHETEACKMIEWDIWMIQFWEVVSVGWWWFDFGRHVTDRSTYPAPGMLSWIPLWKYGYLLNFHPYSCALRHSPRAALVGKWLMNTLAFVQWAISLHLWSSSADPQSTYSTYDCLASQISTAPGTSMCPVEQICARDILFRSYDFAFSDESMDVTDPEITMFVAFIILSVGVVGRFFLIGVGPVVLHLMEKGSIQELKAKAYEMDIGYAGSVGGASLVCIIVGGITTAGAILAFWHGRESAFVIDWTCKTVHVNLSNWRYYLDVEYELPLRAVKMWFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PL34</accession>
    <name>A0A0G4PL34_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">UTP--glucose-1-phosphate uridylyltransferase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S020g000238</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a central role as a glucosyl donor in cellular metabolic pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>alpha-D-glucose 1-phosphate + UTP + H(+) = UDP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 7"/>
    <dbReference type="EMBL" id="HG793153">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PL34"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00897">
        <property type="entry name" value="UGPase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000001">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000002">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016267">
        <property type="entry name" value="UDPGP_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43511">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000806">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL27079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="517" mass="57468" checksum="CBADD8BC3E2FD4E5" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PLW7</accession>
    <name>A0A0G4PLW7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S022g000090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793155">
        <property type="protein sequence ID" value="CRL27410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PLW7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL27410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="178" mass="21013" checksum="176245E3E254516A" modified="2015-09-16" version="1">MAQTRQQTRQKAYSYKQKKDTLNSRIKKPSRRFTGLKDTISKSTVPAKPKIEFLPALLLSVCYPDEYTTLIRLADYVLADEEAEESTEEIYNLIKSVRKLEVPDHTSRQNALEVEMNAERVKESQETEVEYEKRMDFASYWVRSLPIREAKWIWRARVVIERYVDSTRKHSTCIRGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PLY2</accession>
    <name>A0A0G4PLY2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S022g000013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793155">
        <property type="protein sequence ID" value="CRL27334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PLY2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL27334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="164" mass="18672" checksum="1DFCF2041E34CFD6" modified="2015-09-16" version="1">MTLSDKPSNESRMHTLLADFKTSIEASDRARVSVEPTVSPQKIRRSILKSRERTSPRRDRPEDRPLKRVRFKPASGVPLEEFVPSGARAAEKSIASWPSRRKRSLRGKVKPDERQSPHNGGNSPQSMKNKDHIEALGTEVKSLKRELETMRSCRSDARSSERDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PM25</accession>
    <name>A0A0G4PM25_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Neutral ceramidase</fullName>
            <ecNumber evidence="5">3.5.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S021g000148</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an N-acylsphing-4-enine + H2O = sphing-4-enine + a fatty acid</text>
            <dbReference type="Rhea" id="RHEA:20856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="EC" id="3.5.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the neutral ceramidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.23" evidence="5"/>
    <dbReference type="EMBL" id="HG793154">
        <property type="protein sequence ID" value="CRL27233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PM25"/>
    <dbReference type="STRING" id="1429867.A0A0G4PM25"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2300:FF:000004">
        <property type="entry name" value="Neutral/alkaline nonlysosomal ceramidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2300">
        <property type="entry name" value="Neutral/alkaline non-lysosomal ceramidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006823">
        <property type="entry name" value="Ceramidase_alk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038445">
        <property type="entry name" value="NCDase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031331">
        <property type="entry name" value="NEUT/ALK_ceramidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031329">
        <property type="entry name" value="NEUT/ALK_ceramidase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670">
        <property type="entry name" value="CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670:SF1">
        <property type="entry name" value="NEUTRAL CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04734">
        <property type="entry name" value="Ceramidase_alk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17048">
        <property type="entry name" value="Ceramidse_alk_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase N-terminal" evidence="6">
        <location>
            <begin position="60"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase C-terminal" evidence="7">
        <location>
            <begin position="599"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="513"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="553"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606823-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606823-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL27233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="764" mass="83445" checksum="CD16463D9763C29F" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMM0</accession>
    <name>A0A0G4PMM0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily, general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S022g000066</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793155">
        <property type="protein sequence ID" value="CRL27386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PMM0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PMM0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF50">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL27386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="153" mass="16900" checksum="7E02A0AD2B1B19F9" modified="2015-09-16" version="1">MSENAFFPLVIYYMTKFYRRGELARCLAVFYAAQSIASAFSGLLASWRYLFLIEGVGTVVFGLIGIYPDAAGQLCSCEREAEHPGFFQNFKHGTSWAILGIQIRLGVPLQSVQLFLPVIIARLKYSTVKTNLYTVAPNVSGAVVLLILAFCSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMX8</accession>
    <name>A0A0G4PMX8_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S022g000173</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HG793155">
        <property type="protein sequence ID" value="CRL27493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PMX8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PMX8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000003">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361:SF433">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="339"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL27493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="515" mass="58226" checksum="A369C6B9B3D26CA8" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMZ8</accession>
    <name>A0A0G4PMZ8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S023g000187</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793156">
        <property type="protein sequence ID" value="CRL27729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PMZ8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PMZ8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052761">
        <property type="entry name" value="Fungal_Detox/Toxin_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425:SF2">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="29"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL27729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="799" mass="90109" checksum="43DE992DC25DB2AC" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PN60</accession>
    <name>A0A0G4PN60_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyisobutyryl-CoA hydrolase</fullName>
            <ecNumber evidence="3">3.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">3-hydroxyisobutyryl-coenzyme A hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S023g000069</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="3"/>
    <dbReference type="EMBL" id="HG793156">
        <property type="protein sequence ID" value="CRL27611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PN60"/>
    <dbReference type="STRING" id="1429867.A0A0G4PN60"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000026">
        <property type="entry name" value="3-hydroxyisobutyryl-CoA hydrolase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004127">
        <property type="entry name" value="PRK05617.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="7">
        <location>
            <begin position="45"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL27611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="473" mass="52985" checksum="EA059A2F1B13A6BB" modified="2015-09-16" version="1">MPLRAKVTNPAFRATAMMSTTPDIPKELPGDERDDVLFNSIYGIRSVELNRPKKLNSLNGSMARKILPRLKEWEKSHLANMILISGAGTKALCAGGDVAILAQQNESGAEGQKASTEFFGLEYRLDHLIATYSKPVISFMDGITMGGGVGLSMHAPFRIATERTVFAMPETTIGFFPDVGGSFFLPRLDGETGTYLALTSERLKGVQALYAGIATHYLHSSVLSSVAQRLSELTFPDHVELPERLEIVNKTMAEFSLGLPPLEEEPMLMAGSLRTAIDRCFGFNTVEEIIQALEKETEHKEWAQKTLETLSGRSPTSLKVTLRQMRLGKKWSISETFQREHEIAAKFMRHPDFVEGVNARLVSKPARQAEWKPATLEEVSDKTVNDFFVIPNKQSRLALLSEGDYKYYPHARFALPSEREIEEVVRQGHASRRPVVDYFLEKYAHREGVRRKVVEVIARRTTTSSPEGLKWVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNH7</accession>
    <name>A0A0G4PNH7_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="12">1.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S025g000045</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.12" evidence="12"/>
    <dbReference type="EMBL" id="HG793158">
        <property type="protein sequence ID" value="CRL27987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PNH7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PNH7"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000020">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF76">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 9 12" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="13">
        <location>
            <begin position="60"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="198"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="258"/>
            <end position="259"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="10">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CRL27987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="385" mass="41513" checksum="097FA83994AF3DD1" modified="2015-09-16" version="1">MWESPRPHPFINPPPPPDLLFFFFFSSSPSHFSLFINYFTITLTASSKPQSWLSKSVSTVSVVLAAFSSINNPDVEVVAVNDPFIETHYAAYMLKYDSTHGQFKGEIEHVEDGLIVNGKKVTFFTERDPAAIPWGKAGAAYIVESTGVFTTQEKASAHLKGGAKKVIISAPSADAPMFVMGVNNKSYTKDVNVLSNASCTTNCLAPLAKVINDNFGIVEGLMTTVHSYTATQKTVDAPSSKDWRGGRTAAQNIIPSSTGAAKAVGKVIPELNGKLTGMAMRVPTANVSVVDLTCRIEKGASYEEIKAVIKAASENGELKGILGYTEDQVVSTDLNGDERSSIFDAAAGIALNANFIKLVSWYDNEWGYSRRVVDLISYIAGVDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PP49</accession>
    <name>A0A0G4PP49_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alcohol dehydrogenase superfamily, zinc-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S026g000024</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793159">
        <property type="protein sequence ID" value="CRL28159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PP49"/>
    <dbReference type="STRING" id="1429867.A0A0G4PP49"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08254">
        <property type="entry name" value="hydroxyacyl_CoA_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="18"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL28159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="355" mass="38279" checksum="023111D54CFDD9F3" modified="2015-09-16" version="1">MGSTALPSTMHAWRKHKGNPNPIWEELPLPSTPATGFLVKLLASGVCHSDQPLLDIEDRPQFDEKYTLGHEGCGEIIQIGEGVTDKRFKLGDRVALIAVPGCGLDTCSECSRDLAQLCPAGMHHGIGQDGFYAEYVAVDVRAAIPLPDGVEPAVAAVATDAVTTAYHGITRRAEVKKEETTFLFGLGGLGFNALQIVRTIGARVIVSDLRQEKLDAALKLGVPAEDIVPVGKSVQDFVKENGLQGKIDTVLEFVGSNQTNQDAQQIVRPGGKILCVGTLDLINGLDMKIGIRKRLSIIFTYGGQYRDLVEVLDLIAKGVIQPQVELGKLQDFPRVLKELGEGKIKDRIALVSDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPU6</accession>
    <name>A0A0G4PPU6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S027g000131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793160">
        <property type="protein sequence ID" value="CRL28442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PPU6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PPU6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL28442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="251" mass="28750" checksum="222523C283C8382D" modified="2015-09-16" version="1">MAAIINQLNSVARDLDALNLAMRDISLSGTDLQTLETVAANLKDIIVVIEAKAGLRKRPWMEQAWKDSEPYRLKAQSIIATVLSKGRLHNPAVFRRNIKLIYCGSQQSEFDSKDTKWRRGVVQKRCSRIQQLSPDGIVSWAIAYPPTTWGPCFMSNDTFDCLIEDIEPRDRKKWPDAVCQTLSRLKDGEVQGCYSLEQLVHNLENPSQQDEFTNPDMPIQAVQTAPRNPDNEHRGKTYRLRCRIYFDSLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQB9</accession>
    <name>A0A0G4PQB9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S028g000127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793161">
        <property type="protein sequence ID" value="CRL28574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQB9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PQB9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43039">
        <property type="entry name" value="ESTERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="307"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL28574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="553" mass="61659" checksum="C130889C01A7979F" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQS3</accession>
    <name>A0A0G4PQS3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S028g000071</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793161">
        <property type="protein sequence ID" value="CRL28518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQS3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF92">
        <property type="entry name" value="AGL026WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="63"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL28518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="505" mass="55802" checksum="4F62BE77C56FF2E8" modified="2015-09-16" version="1">MSPRNPEVEVEDIDKSRIDNVEIVANADRPNPQKEAPAYVANLTPEERTKAEKALVRKIDIRLLPMIILMYILNYLDRNNIASARLAGLEEDLGLVGYQFATCVSILFVGYLLMQIPSNLMLNKFGKPALYLPIAMILWGIISTATAAAQSYAGLVVIRFFLGFVEAAYFPGCLYFLSVWYTRKELGFRTAALYSGSLLSGAFSGLIAAGITRNMDHVLGLRAWRWLFIIEGAVTIMIAFAAIFVLPNFPRTTSWLSEEGKQLAAWRLEEDIGEDDWVDSEQQSFLHGAKLAFTDIKTWVLMLMILCIVSSASVTNFFPTVVKTLQYGNIETLLLTAPPYCLAVICAFGNAWHADRTGERYFHVTAPLYISVVAFIIAATTTATAPRYVAMMLMVPSFYSGYVVALGWISNTLPRPAAKRAAALAAINCVSNASSIYASYMYPDSQAPRFIPAMSVNCATAFIAIVSATVLRFMLVRLNKKLDRGEEVEGAVPGEGSRRGFRFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQW5</accession>
    <name>A0A0G4PQW5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S028g000106</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793161">
        <property type="protein sequence ID" value="CRL28553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQW5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PQW5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF7">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="87"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL28553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="433" mass="48064" checksum="2F827873DA6DCD72" modified="2015-09-16" version="1">MLKPTKADSFMHHQTSMNFNQNRGEDKELSIYSRSNKINLRGDHSTMATSTSKPTQPKEMLPPPPPPNSVLGRHRLLAPSASVRVSPLSLGGISLGDNWKGMMGECTKEQAFELLDAYYDLGGNFIDTANMYQFGQSEEWIGEWLQKTSRRSEIVLATKYTLSPIFGKSVQQSNYGGTGTKSMRVAVDDSLKRLQVDYIDLYYVHAWDFATSIPELMQSLNTLVQQGKVLYLGISDTPAWVVTKANAYAREYGLRPFSVYQGRYSAMMRDLERDIIPMARDEGMAIHPWGVLGSGYFRSPDAATKEGGRQTPHVKTGREEQVSAALDSVAKRHQVPITSVALAYALQKAPYIFPMVGGNKVSHLKANVEALSLELTPEDVAEVDKGYDFDLGFPHNFLNLAGFMPQGPQHVSFLAGLGHFDYVEPTTAIKPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PR08</accession>
    <name>A0A0G4PR08_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="14">SNF2-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S031g000020</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793164">
        <property type="protein sequence ID" value="CRL28852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PR08"/>
    <dbReference type="STRING" id="1429867.A0A0G4PR08"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
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    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
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        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="DUF4187"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GPATCH11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032:SF0">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13821">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL29548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="362" mass="41294" checksum="4A0C24F609D00B6F" modified="2015-09-16" version="1">MASEDEDDYMNMVIEEPTQKETFTQKKRRELREAEARGRVPSKAERAAREAARREEALATSTLNPTNKGFQMMAKLGFKPGGVLGKPAANDSDTTNTTDFLKSRAEPLNLTLKENRGGIGLDTEKKRKLREEAEEAAKRIKHEEGSYRDRVREERELKRIEAQVHAAQKVAERLDGESESGATPDKEKEQGTGSSAKFNKEEGDSADPSQARDGADTPATKKKPIKLTSQINVLYRGLIRERERKDSDRQARHALQSSLPSSFFPKLRLPEYDDPTMDREDKKALDRELDSELDQNTSTLEIELEEDDEELDAFNALEPAERLRKLVLFLRETYRYCFWCKYAYETDLELEGCPGLTEEDHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PTW4</accession>
    <name>A0A0G4PTW4_PENC3</name>
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        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">PCAMFM013_S040g000022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793173">
        <property type="protein sequence ID" value="CRL29796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PTW4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL29796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="241" mass="27379" checksum="1122A1B4E5434513" modified="2015-09-16" version="1">MPHNESDAERRYKPCQVLSDHRVPYVIWFEDTLHHYGVPTVKFNLYLLVSDLDEAAELLVKAGWVLDSQGPRKIGNAKVELPQKRLISPTSKTITVLLPAEEWKFPLIVDSPSDEKPLTADSPENVSFPPLPGFLDALIESWLDCPGDDAMLLLHLACQISYLYAHVPAVKQRSFAEQIKYEHRQFHFDVLAGMETGTIPFRKHQRAIRDALLQGQYELRECSASRDNEDLFNTGRVGISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUG4</accession>
    <name>A0A0G4PUG4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S042g000010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793175">
        <property type="protein sequence ID" value="CRL29951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PUG4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="53"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL29951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="470" mass="51063" checksum="D0B55817D0D40FC8" modified="2015-09-16" version="1">MDHTYDNLSGLDQARHNSTISMARSMRVAKQERSLVVERDEKPRKQRKRALVACNRCRKRKIKCNGDLNTGLACSSCRSVGATECQYIRVNSLAPEDAAREAARLYATKGQGRSILMGSPQMRAPYQREEYELDIQSNFSRQPVGMDHSYDDQSGYHGQTSPGYMLSNTQGAMLDYGTAWGNRAWDLNGRPNGEFFEEQSTNMNHAYGFVLPGHAMSTEMPQSTGAMTAYTDAVDRTLPTPPTCRSQPQQNINLSTLPDGLSGMTLAADPKGWNSRYATGPDGRAVAMPTVPSNGLYNNIPSAPARIKSTDSDDGTPDLVFGYIPMSTTEDPSPLPAAISSSMATSAANPPYPALDTIENTLVGEYNTSGRNFSRDSNAGQRLLTLTSDCAPDVYGYAGSEHRKSRGVVESDVRCSAPTLVNGLPYTRVRHADSAVGLPYGFLADGLSDYGRSVDLHRSPISPLGHQGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVH5</accession>
    <name>A0A0G4PVH5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2,3-cyclic-nucleotide 2-phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S045g000045</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793178">
        <property type="protein sequence ID" value="CRL30179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PVH5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PVH5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22439">
        <property type="entry name" value="KH-I_PCBP_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22455">
        <property type="entry name" value="KH-I_Rnc1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22456">
        <property type="entry name" value="KH-I_Rnc1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
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    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="108"/>
            <end position="178"/>
        </location>
    </feature>
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        <location>
            <begin position="191"/>
            <end position="262"/>
        </location>
    </feature>
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        <location>
            <begin position="394"/>
            <end position="464"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
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        <location>
            <begin position="304"/>
            <end position="392"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="373"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL30179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="470" mass="48888" checksum="6203DB1D83E0797D" modified="2015-09-16" version="1">MSASPSNLQSTKRPLEDPSSPSGPNDQPEAKRPALDKVVKSDADAEAETDVSSSQVPTVEDAKDTQGDTVVPDAPNGKGLPVDTQPIQSTASQADRAGSDQPPQDESSWVHIRAVISSPEAATVIGKGGENVSQIRRLSGAKCTVSDYSRGAVERILTVSGPQDAAAKAFGLIIRTLNNEPLEAASTAQSKTYPLRLLIPHILIGSIIGKGGSRIREIQEASGARLNASDACLPLSTERSLVILGVADAVHIATYYVAVTLVEQLSERYGGPAASAYATRSGGPAGAVPGGMQVVPYVPQPAGGQYGHPETFKRHHPHPNRAGGGAYGVPYLHGQPAPAPVPQTPMHFPAAPQAAYGGAGPHQPAPFAGGPQQPTPGRGPPTAPAPVGAAMPGQPLTQQIYIPNDMVGAIIGKGGAKINEIRHLSGSVIKINEPQESSNERLVTITGTAECNQMALYMLYSRLESEKHRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVV4</accession>
    <name>A0A0G4PVV4_PENC3</name>
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        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CRL30446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PVV4"/>
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    </dbReference>
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        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="77" mass="8300" checksum="B77E597447EFFA91" modified="2015-09-16" version="1">MMVEKNHFKLPPPLSARGLTHIGEQLQKEIIPGLMRSTLESFLCRICLDRLTTGSLTGTLASSTDLSSDRTTAPGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PW41</accession>
    <name>A0A0G4PW41_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">PCAMFM013_S054g000019</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF281">
        <property type="entry name" value="ASPYRIDONES EFFLUX PROTEIN APDF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
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    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="392"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="36"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL30562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="425" mass="46050" checksum="4679BD49A9A14CD6" modified="2015-09-16" version="1">MSTSHIGRATPNSSEGPEPDRLELEKLTEFPEGGTRAWMVVLGAFCVSFSTFGYMNAFGVYQDYYAENFLSNETSSSISWIGSVQVFFLFSGSLIGGPLFDRYGASIIHIPAIAIVLSVMMTSLCKKYYQFMLAQGVLGGIASGMLFAPVMTCVSHYFHNRRAAALGVTVSGSSIGGVIFPIALSKMLRNESLGFGWSVRIVGFIILFMVLIAMVTVRERLPPRHGKILLPAAFTRAPYTLVTLGISFMMWGLFTPFFYLPQYAQSYGMDSQLSSYLLSILNAASIFGRILPGMVADRIGRFNILIINSLCTGILLLCWITITSNASIIVFAGLYGFFSGGIVSLMSPCIAQVTPSPDQIGTHLGMSMAIIGLAGLTGTPICGTLLERYGTYTQAAVFSGVVMLFGVVLVTVARFYLRAKLLEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PWX2</accession>
    <name>A0A0G4PWX2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S066g000016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793199">
        <property type="protein sequence ID" value="CRL30987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PWX2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="120" mass="14068" checksum="1F0171511ED9896E" modified="2015-09-16" version="1">MAPEVSRVKREQLRKRLKNLLRRHNDFWRLYSIRSWVVMEMPNGRLYTYYSHPDISVPTRQDIKKGPQRAVHKSPQDYEQGSSASDTVPKLPAITILGRCNELWGSLSQYVSRQSKINIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PY54</accession>
    <name>A0A0G4PY54_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S073g000010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793205">
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            <end position="86"/>
        </location>
    </feature>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL31079.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="810" mass="87680" checksum="84EC2C0D7F48E1AE" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
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                <person name="Ceppi M."/>
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                <person name="Debuchy R."/>
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                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <dbReference type="EMBL" id="CRL31466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="240" mass="26342" checksum="1D0DD81313B72D1E" modified="2015-09-16" version="1">MPKRSNEKRLKLNQQCREALAANICTRGPLPTITQLILLDDRLGIVVAPEKVRLQPRPEDGYAWSVTSANASVLKSSLSSGKIHLYRKICNEIGHSIEAVSPHALGHSQSNTSCIPRESLEAESFGDGMDGSFTAEISKLKAANSSIEIELERTHARLNDCLDESHTVRAEANELRHDMQILRSHNKKLHDELTEAKAGIAGARRILNSLQTEGIEIEVGTRDIQSSANGIHEVASEILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
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    </gene>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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        </location>
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        </location>
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    </evidence>
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    </evidence>
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            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL17151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="443" mass="49881" checksum="BF1FFD808F4B931F" modified="2015-09-16" version="1">MPVPHLRRTSLANPGRSSMEDSPPSGEDEVVEPDQGNVLSHIISQLRPGADLSRVVLPTFILEPRSMLERITNFMAHPETLLPMSAIEDPVERFVSVVKFYLSGWHIKPPGVKKPLNPILGETFTCYWDYPDGTRAYYISEQTSHHPPKSSYFFAAPEHKIRIDGTLKPHSKFLGNSAASIMEGIAILRLMNHGDKEKGERYILTQPNMYARGILFGKMKYELGDHSYVRCPENNLVADIEFKTKGYFSGTYNAIGGTIKNEKTGEVLYELSGLWNGEMDLKDVHTHKKDVLFDATHAKHTAPLVRPMEEQGERESQRLWHNTVQALLSRNHEAATDEKTKIEDRQRDEAAKRADEGVEWRPRLFRPIQGGPGGPDEGEEDLDWIINAQVDMHDPQVATKQILSIAPILQGSETKTDATQSTVERTDTQTSEVEKFVDAQEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NSW3</accession>
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        </submittedName>
    </protein>
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    </gene>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005194779" evidence="1">
        <location>
            <begin position="20"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="SnoaL-like" evidence="2">
        <location>
            <begin position="48"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL17166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="186" mass="20132" checksum="8BAC6D6C15F24F24" modified="2015-09-16" version="1">MKFLSFCALSFAIASSAVASTANDIAPIEISSLASGYAPEIYTDAGTIEAIRNTLAIYAFAVDGKDFDALSKVFTTDAIANYSAPLNVLTPLETIQSVLSTSLGCVTTQHLYGTQRIDVLSPITAKSVTYFRAAHFGKGDKESGVDYAYGQYQDNWQRQATGTWRIVHRNLVYMGPQIGNMSVFVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NT30</accession>
    <name>A0A0G4NT30_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S001g000197</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
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</entry>
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    </evidence>
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</entry>
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            <dbReference type="EMBL" id="CRL18222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="401" mass="43445" checksum="86E7A7BB3E1BF84E" modified="2015-09-16" version="1">MGRTVDQEVHAAFVEFRAKEDDKCLSVQCIYCQQIRAKNTSRQKQHLLECPGLRGHPNAPQPSQPAQAAPNGIGPPNGYPGTPNGPTATPSGPTGPGTIPTPNGTLMTNGVNPHATPLQTPLGALQNRAAMATPVPPTGPPSAPPSAVPSRPTPKPKAKTSSSSLPAPPLDDVHAAFVEFRAKEEDKCLSVQCIYCQQVRAKNTSRQRQHLLECPTYLSVMKDSIPANNLLHTFPEGDVARSLQIPAPSLELDFRMSIKMNPKVSVGPSVWGQREWVSFIGGQWAGRWGKGIVLPGGQDTQIVTKDSTTNLRASYILQTVDEPPAFIIVRTEGWLTGAKDVLEKVIDANMADGVNPGSYKYRVNLSMETGDERYTFLNTLMWIGSGCRRGHEVIFDSFRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWF7</accession>
    <name>A0A0G4NWF7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S002g000256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWF7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL18386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="420" mass="46671" checksum="9DA8907D0A1B22F6" modified="2015-09-16" version="1">MPVSTRYASAKPTLYKRPSKADQQQGIYTVDLAQNYAKQFNAAGNFIEPPQQVALSDASYLQPYLWQLTHKPKGKSLPYRGFRFGQVVGPIKRLSTLEESNTVLVIDHDSPEKTKFGVDLRYSPSDLVITYGESTVVLTALTNLTAFHPKGGPNGNQVMDKPGNVVEDTWDAAKAAPYSRANKPDDEKRNEKQSDNPAETASPTQGPTGANQPNTTTSSTHIPVPTLNAEVVPPTANTERGVHERHEQQNEQHTIDLTNPGVPTGWQSPTTTVRDMFRGFDDDITTECDDIDGISQSAWVWRKFDGELQGPERRQIIRMYIDATDARREYEARMALAEARVRSRRDGALKHVLRRLLDSVRLPAVDEVREGLDFNDRSFGTKAPPHFMYLPGRGRPAPRGVGRCDQQADGLRQPTAGPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NX52</accession>
    <name>A0A0G4NX52_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S002g000572</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NX52"/>
    <dbReference type="STRING" id="1429867.A0A0G4NX52"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF6">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AN1598-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL18702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="504" mass="57642" checksum="5C49879632210D71" modified="2015-09-16" version="1">MAILRDQTVGTFLGGNWAILLLVTVAVTIGIRLIPRRADVPVYSRHSGWRGQWKDSLEYLHDSAGTLRAGYEKFSRHGQFFQLRTPIRWIVVVPPKLVDEIRTAPPTHLSAKESANDVLQTRYTVSPIVEAQKFHFHIVKTHLTPNLENKIDDLRDEIKLSFGDEIGSPTDWKPVVMSRAAHRIASRTANRLLVGVPLCRDEEYLDMSIKYTIDVFGGADKLRAWPKFLRSTVTQFVTNVKERQRVGRKHLIPYIKTRLQEESDGLIEKPPIDSLQWVMDAAPNAGERDPERLMFRLLHLNVAAVHTTSVTYLNAMLDLAFHTEIHEELRTEIESVVKEHGWSGRALSQMWKLDSFLTESQRLSPLASSQMTRAVIQDFTFSDGTTVPKGSYVLAPMYAMYLDDDIYPNASTFDAFRFSKLRDQPGHENRHQFVTTSPTHINFGHGKDACPGRFFAAQEIKLLLAHVLQNYDVRLEDPTKLPEGSWYDRSRKPNQTARVLFRCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXA7</accession>
    <name>A0A0G4NXA7_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Tethering factor for nuclear proteasome STS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S002g000623</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 9">Binds the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the cut8/STS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NXA7"/>
    <dbReference type="STRING" id="1429867.A0A0G4NXA7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031144">
        <property type="term" value="P:proteasome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1590:FF:000001">
        <property type="entry name" value="Tethering factor for nuclear proteasome STS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1590">
        <property type="entry name" value="Tethering factor for nuclear proteasome Cut8/Sts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013868">
        <property type="entry name" value="Cut8/Sts1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038422">
        <property type="entry name" value="Cut8/Sts1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28032">
        <property type="entry name" value="FI02826P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28032:SF1">
        <property type="entry name" value="FI02826P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08559">
        <property type="entry name" value="Cut8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL18753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="311" mass="34281" checksum="C53A4E314770BE8C" modified="2015-09-16" version="1">MNSLVATPPVPPHFYENSRFSPSRMMSTPSSSYASRKRKADDDNDHDGRMSASPTNSPAFTPRQLPHSYRNIKRSRPNVSGRPLSLPRLLETLDTDALRTVVRTMCERHPQLADEVVHTSPRPNVSSTLQVLRNYQAALQSSFPLGGNTESDYAYNRVRQPLTNLLDALSDFTPNFLPPNETQASTSLSYLDGATDIIHALPRWSTPQNNIERDSAYDEMCKAWVLVIREAAKRGGGIQLQYGGWDQKLAKHNQTSGGKLQGAVNELGFSLGWMGGPDTPSHGANNDMGSIRDQLFSGTYGLGTPVKVGPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXH5</accession>
    <name>A0A0G4NXH5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Nucleoporin protein Ndc1-Nup</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S002g000631</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NDC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NXH5"/>
    <dbReference type="STRING" id="1429867.A0A0G4NXH5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106166">
        <property type="term" value="F:spindle pole body-nuclear membrane anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070631">
        <property type="term" value="P:spindle pole body localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019049">
        <property type="entry name" value="Nucleoporin_prot_Ndc1/Nup"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13269">
        <property type="entry name" value="NUCLEOPORIN NDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13269:SF6">
        <property type="entry name" value="NUCLEOPORIN NDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09531">
        <property type="entry name" value="Ndc1_Nup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CRL18761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="657" mass="73103" checksum="A1A15BCBBDE79B18" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXU3</accession>
    <name>A0A0G4NXU3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S002g000750</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NXU3"/>
    <dbReference type="STRING" id="1429867.A0A0G4NXU3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031469">
        <property type="entry name" value="SesB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17046">
        <property type="entry name" value="Ses_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="7">
        <location>
            <begin position="16"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal death-pathway protein SesB" evidence="8">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL18880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="320" mass="35418" checksum="82B7CF024475EB6A" modified="2015-09-16" version="1">MSIRVVREPANAKVDIVFVHGLHGDQAPWTSEADVFWPDKLLPAKVSDACILSFEYEAAIGSFFDEDDEITDISNDLVNELMDHRTEKEKEERPIIFVAHCLGGTVLENALVRAAEHPRKKELIGCIYGILLLGTPHFQAGSLAAATKYFQVAQAEIPSESDLKDRLDRLGTIPRAFAGLKEAGAEFEVEAFYAGAGTKLGGKDVKIVDEALARSPEAPPPERLARNQLLLSQYDSEDDKDYKKVSRILTQWASKIVLPEDDKGAQNVSNATFSGSHNSGLQLGQNVGTLKGFSFGRDQPQKRTIFDDLRLTPIPRRWTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXW8</accession>
    <name>A0A0G4NXW8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyridoxal phosphate-dependent transferase, major domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S002g000803</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NXW8"/>
    <dbReference type="STRING" id="1429867.A0A0G4NXW8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008732">
        <property type="term" value="F:L-allo-threonine aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000030">
        <property type="entry name" value="Low-specificity L-threonine aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041359">
        <property type="entry name" value="GntG_guanitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="L-THREONINE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097">
        <property type="entry name" value="L-THREONINE ALDOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017617">
        <property type="entry name" value="Thr_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aromatic amino acid beta-eliminating lyase/threonine aldolase" evidence="6">
        <location>
            <begin position="35"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017617-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL18933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="391" mass="42357" checksum="4A20CB5E5F78D98B" modified="2015-09-16" version="1">MSGVQVCSVQHETTQPAEQIEVSSSWCGAGPAAYDFRTDTITTPTLSMLKAIAQTTLMDDVYQEDSTTNDFEKFMANLTGKEDSLLVMSGTMGNQIALRSLLTQPPHAVLCHYQSHILKSEAGGCSSLSQAHMQPCIPANGQYLTLEDIQRDVDTRDNIHIAPTCVISLENTLAGVITPLEEVRRISTFARANNIKMHLDGARIWEAVAAGAGSLVDYLDCFDTAQMCFSKGLAAPVGSIIVGPKNTLQHCRWVRKSIGGGIRQAGIISSAARVAVEENFGNGPNGEGGRLRETHKKAKSIEKMWVDRGGAVSRPVNTNMVCLDLPHSGITVDRIICVGREEGVKLFGGRIVVHCQIADDAIVRLGNVFDRLLSSTEKREEVVQGSDSVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYI4</accession>
    <name>A0A0G4NYI4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like 1-activating enzyme E1A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S002g001003</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL19133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NYI4"/>
    <dbReference type="STRING" id="1429867.A0A0G4NYI4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01492">
        <property type="entry name" value="Aos1_SUMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF162">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="7">
        <location>
            <begin position="19"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL19133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="393" mass="43979" checksum="F7B8AABBE03027E1" modified="2015-09-16" version="1">MAEQQDNAQSISADEIALYDRQIRLWGVHAQEKIRSANILLITVKALANEVAKNLVLAGIGSLTIIDHQDVTEEDLGAQFFIAEAQSEQDVIGKNRAQVAGPQIHKMNPRVKLNIDTSDVKTKQPDFFAQFDITIATELDFLTNTTVNAACRLANRPFYAAGLHGFFGYVFADLISHDFVIERNKSNMAPATQETPTRSIIDITTKTEENKTNKKEPNKIIELVTKREVYTPLILANTSPLPEEYTRLARRRKQVTPLLSCLRALWEFEKLRGHRPTFTHEDLELFTKLSRDRHQELKLEPLTLDSVFLRTFLQNLGSELSPIAAFLGGSLAQDVINVLSAREQPLQNMLLFDGEKSVGPIYSLHPFFPDVGVEMAAVPPVRNPVTVPVAGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYY0</accession>
    <name>A0A0G4NYY0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S003g000047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NYY0"/>
    <dbReference type="STRING" id="1429867.A0A0G4NYY0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42820">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42820:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL19256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="199" mass="21183" checksum="86BD976E4E9F5B6A" modified="2015-09-16" version="1">MQVEGVALVLGAGPDREAYEATAYHVDVREEAQVQALVARVKDRYGRIDICVTTAGTSAANQSPISDMSLEAHRSMDEVHNIGCLLVVREVIRAMISQDPVLTRRQNQARGSIVVLTSLALEGAFLGVGNYIAAKHAVKGVVQTADAMLGDLPMRRLANPEEVADAVVCLTSQAATYINGHTLVVDGGSSLQLSNQPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-11-27" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0T7</accession>
    <name>A0A0G4P0T7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Heavy metal transport/detoxification protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S003g000718</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ATX1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P0T7"/>
    <dbReference type="STRING" id="1429867.A0A0G4P0T7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000008">
        <property type="entry name" value="Copper transport protein ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051881">
        <property type="entry name" value="Copper_transport_ATOX1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365:SF1">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="HMA" evidence="8">
        <location>
            <begin position="3"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL19926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="79" mass="8488" checksum="AD6F2A66FF0AD37E" modified="2015-09-16" version="1">MSDHQYKFNVTMTCGGCSGAVERVLKKLEGVKTFDVSLESQTVNVTAEPTLSYDDVLEKIKKTGKTVNSGEADGESKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P159</accession>
    <name>A0A0G4P159_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S003g000810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL20018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P159"/>
    <dbReference type="STRING" id="1429867.A0A0G4P159"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000318">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF2">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="77"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL20018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="504" mass="55828" checksum="82A3D25AB60C1046" modified="2015-09-16" version="1">MEKMDSQHQHIEGAKASPQGMESGKQCDFYVEDRVAHLSEEHRQYILAKHGTLDVEPIPDMTDADPYNWPRWRKNLNLTLVAFHAMMGTFTASSIQSAFENISEDLDVSMQRTSYLVSLFIAVLGGAPLFWRPLCNRYGRRPIFLISLICSLIGNVGCANSPSYATMGLCRAITAFFISPAAAIGSAVVAETFFRKDRARCMGGWTLMVTLGVPAAPFIFGFVALRVGYRWIYYILAIVNAIQFVLYFFFGSESLYVRSNVPSNNVVAAKQSLFGFSRIDPTPLKLWDFFQPLSYMMKPCVIIPAMAYAMIFLWGSIALTIEISQIYPAKFGLNTQQVGLQFLGIIIGSVIGEQIGGFISDRWMLMRQKRTGEPSPPEYRLWLSYIGHGLTICGIVVFAIEIRDSGGAWTIAPVIGAGIAACGNQIVTTVDITYAVDCYREDAASVGVFITFVRQIWGFIGPFWFPQMFEVVGWAGGAGIAVALMVGVSVIPTILVQWRGAGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P162</accession>
    <name>A0A0G4P162_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S003g000811</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL20019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P162"/>
    <dbReference type="STRING" id="1429867.A0A0G4P162"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000051">
        <property type="entry name" value="Cytochrome P450 monooxygenase (Fum15)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL20019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="547" mass="61505" checksum="04032999F3F337CF" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P190</accession>
    <name>A0A0G4P190_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Casein kinase substrate, phosphoprotein PP28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S004g000020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P190"/>
    <dbReference type="STRING" id="1429867.A0A0G4P190"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019380">
        <property type="entry name" value="Casein_kinase_sb_PP28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039876">
        <property type="entry name" value="HAP28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22055">
        <property type="entry name" value="28 KDA HEAT- AND ACID-STABLE PHOSPHOPROTEIN PDGF-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10252">
        <property type="entry name" value="PP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Casein kinase substrate phosphoprotein PP28" evidence="2">
        <location>
            <begin position="123"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL20080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="249" mass="27416" checksum="956501D6F81D2970" modified="2015-09-16" version="1">MAPRGRGGKFSKPTRGGGKHFSRDLQPLDKDGNQMGLWREPGEQIKSSGDEDSSSEEESSEESSEDESKHVESSTAAGTREERRAAAKAKKAAALKKRGQGPAQPGDLPPSDSEESDNELPANPNHTAKSRSQTLKAVEEPTAEPKKPAKVKDISQLSRREREAVQAQQARERYQKLHAEGKTDEAKSDLARLAVIREQREAERLRKLAEKEEKDEQAKERADAAQEREDRMRAAASGKTAKKVGGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P1C8</accession>
    <name>A0A0G4P1C8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA polymerase II-associated protein 1, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S004g000067</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RPAP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P1C8"/>
    <dbReference type="STRING" id="1429867.A0A0G4P1C8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039913">
        <property type="entry name" value="RPAP1/Rba50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013929">
        <property type="entry name" value="RPAP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013930">
        <property type="entry name" value="RPAP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483:SF18">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08620">
        <property type="entry name" value="RPAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08621">
        <property type="entry name" value="RPAP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RPAP1 N-terminal" evidence="4">
        <location>
            <begin position="94"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="RPAP1 C-terminal" evidence="3">
        <location>
            <begin position="293"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="395"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL20127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="459" mass="49715" checksum="489642C312EE1505" modified="2015-09-16" version="1">MAFRGERFLLDLDEESGAPEIPSPSPFSLVGEIQERAPSTAIPPAPKLPTLSASSTGFPAPRQRKPSSFKQRRTNQPTPPAPVPAEPTAQDDKKSIDEENRRQLAAMSDAQIQQEREELMEQMDPGLLERFLRRANIEEDQKTGFEPAAPVADEKPKPRKSVSFDIPSSTPVSTPTAQSHSLPKPPTKPHPRNEDLAPSSLPQDLHPASERPSLDPATIETFHFPQPTTPMPVLDPSSPSFLSDLQSHYFPEIAQDPSTLSWLQPLSADEEDPDSTSAYHPASNAISMAPSAIRFSLRGTILAPETSLSLPTTMGLHHHGEDPHAAGYTIPELAILARSTFPAQRCIAWQVIGRILFRLGRAEFGERGGQLSDGLWFVIEKEGIVAGMLAEADGAAGQTQGRDKGKNTQDTEEGSNLPLASGVGRHASAAAWAVEGIWLWQKGGGGDRGLLKEGQHRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P1T3</accession>
    <name>A0A0G4P1T3_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA (guanine(37)-N1)-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA methyltransferase 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TRM5</name>
        <name evidence="12" type="ORF">PCAMFM013_S004g000217</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="10">Predominantly in the mitochondria and in the nucleus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRM5 / TYW2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="10"/>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P1T3"/>
    <dbReference type="STRING" id="1429867.A0A0G4P1T3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070901">
        <property type="term" value="P:mitochondrial tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.110:FF:000001">
        <property type="entry name" value="tRNA (guanine(37)-N1)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.110">
        <property type="entry name" value="Met-10+ protein-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03152">
        <property type="entry name" value="TRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056744">
        <property type="entry name" value="TRM5/TYW2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025792">
        <property type="entry name" value="tRNA_Gua_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF36">
        <property type="entry name" value="TRNA (GUANINE(37)-N1)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25133">
        <property type="entry name" value="TYW2_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="11">
        <location>
            <begin position="152"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="281"/>
            <end position="282"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="309"/>
            <end position="310"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL20277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="480" mass="54852" checksum="F5095C8C73364117" modified="2015-09-16" version="1">MKPTEPASEQATLNETPAMFRPPVNRAMRTLDRSFFRRNVPLSVARVFKTSDISNVRKELVKSRDILLLPRISPIREVKDQDGKAWKAMLLREDLKVDDKATWSPTINELVNKGTVALGPYELLLEYDHWSYAEIISSILPEDLMEEIPQGFTQVGHVLHLNLRAQYFPYKHILAEVLMDKNPTVRTVINKTEDVGSHSQFRTFPFELLTGENDLNVIQHEQDCEFRFDYARVYWNSRLETEHRRLVEKFAPSEMVCDVMAGVGPFAVPAGRKKIFVWANDLNPHGFEVMQDAITRNKVQDFVTPFNQDGREFIRSSGRLLLSAKPLTVTIRPKVGREKQRKIAEGKGSPVPAPKVYTRPTIVNHYVMNLPATAIEFLDAFPGLYAGEEQVFAPNTEQKLPMVHVYCFSGHSDNEVDDHIDICERISERIGHKITVDDCVGGKGNQELELAIHNVRLVSPKKQMFCASFRLPREVAFRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P1Y3</accession>
    <name>A0A0G4P1Y3_PENC3</name>
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        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase superfamily, zinc-containing</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">PCAMFM013_S004g000238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4P1Y3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
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        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
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        <property type="entry name" value="ER"/>
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        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
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    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF1">
        <property type="entry name" value="OXIDOREDUCTASE (EUROFUNG)"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF08240">
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    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="16"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL20298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="346" mass="37036" checksum="1F256FC25C73A65A" modified="2015-09-16" version="1">MSIPQSYKALRRGTGGLPLTLKLTTEQLPSSLNPQEVLIRIHAVSLNYRDVAIMNGRYPVPVIDQGIPASDCAAEVVLVGSEVKDFRVGDHVAPIFDLNNLTGTEEKAAALGGDVDGVLRQFAVFDQNVLVHLPKHLSWEEAACITCAGTTAWTALDMPRSSGTALLQGTGGVSMFSLLVCLAAGIKPIITSSSDEKLDLARSQGEAGIVETINYRTHPRWEEEVLRLTNGRGVDIVVETVGPTTMVQSLSSLSRRGTVSLVGFLGGFNTEHFPDTIGPVLQKSAIIRGINVGSKIDQQNLCNLLVEKKVSLTSILDASVFSFAESQAAFDHLYAGGHMGKVVIKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2B0</accession>
    <name>A0A0G4P2B0_PENC3</name>
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        <submittedName>
            <fullName evidence="1">Glycosyl transferase, family 8</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">PCAMFM013_S004g000390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4P2B0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL20449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="321" mass="37592" checksum="D8CA4837A1DC2D48" modified="2015-09-16" version="1">MVLVHRNSTFIPHLRKVIAIITCLGLFLWVATPFGFHESADESRPPRYAFATVLMTENDWEFPDVEAPYLQAARLLTFQLLHCPRTRNRIDNVPFLVLVTPDIPQKHRDLLRREGATVIPMENLDYDWGSSQRWDDDLAKLNLWKLEEYEKIVFLNVDSVLFRPLYEVFEDPAAIMRTITKPTAKMPKNYMIAAPHDSRMSLNTQLVSDQEFYEEGEMDSRFFILHPSNDLYKYYASLRHIPDQDDSVRPKQNLLDCAHRADGPMPWQSLGPEWNLKYASQSDYERGLKSINHKWWRPIADDFLGDRIAMAMDEMTAYLNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2B6</accession>
    <name>A0A0G4P2B6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S004g000395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P2B6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL20454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="291" mass="34137" checksum="0C806AFAA470D496" modified="2015-09-16" version="1">MHHLMYRQSKARGDILPPQYYRTAMRQIEKSDCYDHHPPCHVKQATPCPRNSSQVHQPPTINETIHCYSCPLFRSQDPWVKMNNIEPDPGAQHHKICCHNRHESSCAHLQPRARSPESSEDEEYHYYTGNYHTQGIHPNERQHHPPTVNHFHPKGPNDIIDRTHRHAAQPERGTFARATVCKSHEDRCSSKIKAVRFEEDESMPEYADTHNSNCPIHHTPSPVEDRHHSNCNSRQHQSQSLESRTYRQTSIFYGFDRLKVSKNFNCFNPRTYSDNIAMHRNQRRTIHLIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2Y4</accession>
    <name>A0A0G4P2Y4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S004g000627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P2Y4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL20686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="49" mass="5166" checksum="6626381A5AB29C92" modified="2015-09-16" version="1">MHSRPRTGHSIAPIASLTGSARQGFYLDRPKKSPSPCAGALPRPHTQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P4M9</accession>
    <name>A0A0G4P4M9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S005g000401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P4M9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL21237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="49" mass="6178" checksum="114398A78DBD7B0D" modified="2015-09-16" version="1">MAVCRLIICNHLSFFFFFFFFFFFFFFFFFLLLLSIVRKRSTCISYILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P4T9</accession>
    <name>A0A0G4P4T9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Iron-sulfur clusters transporter ATM1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Iron-sulfur clusters transporter atm1, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PCAMFM013_S005g000485</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FM 013</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P4T9"/>
    <dbReference type="STRING" id="1429867.A0A0G4P4T9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140466">
        <property type="term" value="P:iron-sulfur cluster export from the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18582">
        <property type="entry name" value="ABC_6TM_ATM1_ABCB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03253">
        <property type="entry name" value="ABCC_ATM1_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000004">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000186">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF402">
        <property type="entry name" value="IRON-SULFUR CLUSTERS TRANSPORTER ABCB7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="129"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="437"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="36"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CRL21321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="692" mass="76934" checksum="114B655DE612E98C" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P537</accession>
    <name>A0A0G4P537_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-lactamase-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S005g000577</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S12 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P537"/>
    <dbReference type="STRING" id="1429867.A0A0G4P537"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021860">
        <property type="entry name" value="Peptidase_S12_Pab87-rel_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF9">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11954">
        <property type="entry name" value="DUF3471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="14"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S12 Pab87-related C-terminal" evidence="3">
        <location>
            <begin position="404"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL21413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="511" mass="56706" checksum="C70A0F23AE79EA3C" modified="2015-09-16" version="1">MVLRSSNSPLTSELDALVQQQMDKWKVQGLSMAVVHGSSTWSKAYGVAKFPDRKMTTDSLFSTCSTTKAFTAAAMSLAIDDSKNTESPLRWDTPIASILRDDFVLKNDYSTMHTTIEDALSHRSGLSTHNTCLELAHPQRSLREAVRNLRHLPMAYAPRTTFSYNNNMYMVISHALEQIEGRTLGETLKKRIWDPLGMDDTYFSVTDVSQDPSLRPRLVQGYTWDPDTDTYVAEPYMNDVAVTGAGAMVSSVLEYTKWLRAMIYQTGPISPQGRAELLKPRTIITNWDELVGPPPAPCHLYALGWFVDSYRGEPFYWHSGSWPGFGIMVGFLPSKGFGFAMMGNTTNARNAQVEIYMHLLDRIFGGSGIPYPGGQATEAVNRKIGTKSGCMEEAIKRLYPSLPNPIISHSLPLEQYAGKYENAAYGSITLSLGNGCLVADLLDRAVPCLITLAHVSGEFFVAHYYQPKTIGSLSDYCATEFIVGSNGITTAMGMDMEPALNGEKMWFDRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5D6</accession>
    <name>A0A0G4P5D6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="11">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S006g000076</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the phage and mitochondrial RNA polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="11"/>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4P5D6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034245">
        <property type="term" value="C:mitochondrial DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001018">
        <property type="term" value="F:mitochondrial promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006390">
        <property type="term" value="P:mitochondrial transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000041">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1320.10">
        <property type="entry name" value="DNA-directed RNA polymerase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024075">
        <property type="entry name" value="DNA-dir_RNA_pol_helix_hairp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046950">
        <property type="entry name" value="DNA-dir_Rpol_C_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002092">
        <property type="entry name" value="DNA-dir_Rpol_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037159">
        <property type="entry name" value="RNA_POL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029262">
        <property type="entry name" value="RPOL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00489">
        <property type="entry name" value="RNA_POL_PHAGE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
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    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase N-terminal" evidence="13">
        <location>
            <begin position="335"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="47"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1297"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
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        <location>
            <begin position="1297"/>
            <end position="1314"/>
        </location>
    </feature>
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        <location>
            <begin position="1315"/>
            <end position="1335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004026"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CRL21536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1373" mass="155136" checksum="5D9AA060AA5F0143" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5D8</accession>
    <name>A0A0G4P5D8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S006g000063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21523.1"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P5D8"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL21523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="475" mass="53860" checksum="FDE016609ABA1A6A" modified="2015-09-16" version="1">MPDNVPHASNDRSSWQTTLPLYSQEEQEIILEARALREEKLRALADIISSMSVELTNRDVIHMYYRVEVGSYLLPASAFIANENPSGAEVMVNLARESADKSKNALLVARCEFWMGRVEFLRGNMRKAHEHFVKANPCAMDPKEGVECQDLSFYLDVTRHGISEHTRAARLRAHEEAIAAHAKFDKTANNSVSTEDKRKRPLRTWKGALVKLQLPLIKQRPLTKIRKPRCKVPTLPKVDEKHLQQGIDMETNSKNEVLGKVLAEELGYESWSDSGDDTDTDTETEDESDDDPSGGPEDGTDDTIDGNTANSPDAPDETQQPGPSTDTNTAAANFPTGQSAYEMPKPGSARDRFRQECFQMGLTSVVNAEPYERPKELFLFGVPHERTKQTEFRLGFFKVGLTKRCRPMTIFPKQHGEITISPEEWKSIEQDARQKIVTYEYLRRERYELVKVAEDIYCSKPLKTYLGRYKDGIQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5I2</accession>
    <name>A0A0G4P5I2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GTP-binding protein, HSR1-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S006g000108</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4P5I2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="G" evidence="4">
        <location>
            <begin position="18"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="225"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="353"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL21568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="410" mass="46936" checksum="2867433E574437EF" modified="2015-09-16" version="1">MTSKTSLQIVPGAPWVLIAVMGLTGTGKSTFIQTATQSPEVIVGHDLESCTSEMKGYTFHYKGHNVNLIDTPGFDDTHKSETEVLTSIATWLEESYGNHEKLNGVIYLHSINKPRMEGSALRNLRLFRQLCGESPLKNVVLGTTFWGAVNEEAGKSREKELRLRPEFWGQMVERGSRMMRVTDRASALEIVDYLMPMVPVPLEIQKEMVDQEKHLIDTAAGQHMNEELHRREELHREELQKIKEEHELAIEEKDEQVRAILEESQRRIENNLNKIYRQQEQLRAERRAEDRKRQNDYENHIQRIESISRVSLLERESTSDFRDMSFDELVARIRANEIKVNAQNRDKVEEMISETQQSPDLSNSASRKKKGTSRYLLRALKVLTPIVSMALLGVPIMLPSMGGDSDTPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5J8</accession>
    <name>A0A0G4P5J8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S006g000089</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P5J8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL21549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="57" mass="6616" checksum="ED6665B0AC2403C0" modified="2015-09-16" version="1">MEAKRGMYRRSLGAGLLRSTTLYVGNTRTEVMMIYKRWFKNFVTGRAVTATRDPISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5K3</accession>
    <name>A0A0G4P5K3_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex protein EXO70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S006g000128</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Also plays a role in the assembly of the exocyst.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Bud</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the EXO70 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P5K3"/>
    <dbReference type="STRING" id="1429867.A0A0G4P5K3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.170">
        <property type="entry name" value="Exocyst complex component Exo70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004140">
        <property type="entry name" value="Exo70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046364">
        <property type="entry name" value="Exo70_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542:SF41">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542">
        <property type="entry name" value="EXOCYST COMPLEX PROTEIN EXO70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03081">
        <property type="entry name" value="Exo70_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20669">
        <property type="entry name" value="Exo70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex subunit Exo70 C-terminal" evidence="5">
        <location>
            <begin position="246"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL21588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="626" mass="68705" checksum="B3AFBFCB447F15C3" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P604</accession>
    <name>A0A0G4P604_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S006g000300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P604"/>
    <dbReference type="STRING" id="1429867.A0A0G4P604"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="57"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="152"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="57"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="162"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL21760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="193" mass="19842" checksum="FCF5526B0CBC3FBB" modified="2015-09-16" version="1">MSSKVEGAATAGVMATGFTLGDAVATTDILSVPSTSETSTATFTRTQGTTVVIVSSTTSETPSISTPTATASSTATDSPASATPSDEFFGSSTSSDGSELINSGLSGGALAGIGVGVALGVLLIAFVLFFLCRRRRKHQGLTRVTRGDDINRPVLSELGTDGQKHELPAEESRRAELAANERKPNNTHAHELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6C0</accession>
    <name>A0A0G4P6C0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ABC multidrug transporter atrF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PCAMFM013_S006g000354</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>voriconazole(in) + ATP + H2O = voriconazole(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61912"/>
            <dbReference type="ChEBI" id="CHEBI:10023"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:61913"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4P6C0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
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    <sequence length="1556" mass="173806" checksum="8D7BE3D2FDB0CA6C" modified="2015-09-16" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    <sequence length="321" mass="34393" checksum="CC50828F68988AB1" modified="2015-09-16" version="1">MSTNPITRVAIVGATGRIGGAFAQSLLQTGQHTVTTLTREGSDGKVPEGVQVVPVNYDDENSLVKALTGQQFLVITLGVRAPEDLHARITTAAAKAGVPYIMPNAYGFPISPEGVKDTDSYGKIAVARIADAQTGASSSVTLPCGFWYEWSLACGEQWFGFTIKDRKVTFFDDGTRTVSVSTWDQCGRALAALLSLPESGATPALADFKNKDVLINSFRVSQRDMLDSLHRVLGTTDSDWEISHESVAKRLADGAEELAKGVFTGFPKMLYASVFSPTNQESDFAGTMELANDVLGLPKEDLDEATKRVVDMVAGGWSPFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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        </source>
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        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
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        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL22476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="126" mass="13431" checksum="E2615EE7252E5B27" modified="2015-09-16" version="1">MSENLVSKPGFWALLTVVTLCLAGGAGYFIRRWLASKEKGSEGIPLHNIGTGEQREDLPAGDDVEGRLLVVTPATPTTPQTPPPKRKRRLTSSDLSSGSTVVRNSFHGLKEFFGIDSPAGVAGLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P8J2</accession>
    <name>A0A0G4P8J2_PENC3</name>
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        <submittedName>
            <fullName evidence="11">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
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        <name evidence="11" type="ORF">PCAMFM013_S008g000065</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="335"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="481"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="689"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL23036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="872" mass="96711" checksum="E157BDF3BDC680E2" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P9V2</accession>
    <name>A0A0G4P9V2_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xaa-Pro aminopeptidase</fullName>
            <ecNumber evidence="5">3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Aminoacylproline aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Prolidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S009g000036</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="5"/>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P9V2"/>
    <dbReference type="STRING" id="1429867.A0A0G4P9V2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF4">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="14">
        <location>
            <begin position="70"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CRL23096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="496" mass="55205" checksum="A8D6E28C75ABF3C3" modified="2015-09-16" version="1">MAACRFLVRQCAVLMRSSRPLSHSLRQLPRCNPLPRSYATSVAAAELKFGQPLHETHPHILSPGELTPGITALEYAQRRSKLANKLPKGAIAVLAASEVKYRAQGIFNEYRQDSNFFYLTGFNEPNALAIIGNDGSGDNHIFHLYVREKDPKAELWDGARSGTQAAVDVFNADETGNIERIGDILPSIVQGATEVYSDIPTFDGSRSSLNRYLYGPTVASEKLKKVVDHRRVRPLKHLLNEMRVFKSENEVVQMRRLGQASGRAFTEAMRQDFTREKDLYSFLEYQFKVNGCDTNAFVPVVAGGQNALAIHYTRNDDVLKDGDLVLVDGGGEWGSYISDITRTWPVNGKFSDPQRDLYNAVLKVHRSCLALCRETSNLSLDKLHGIAENGLKDELKSLGFDLSGNALNTLFPHHLGHYVGLDVHDCPGYSRGYDLKAGQCITIEPGIYVPNDERWPAHFRGIGIRIEDSVCVGDEHPIVLTPEAVKEVEDIEALRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PA30</accession>
    <name>A0A0G4PA30_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Delta-1-pyrroline-5-carboxylate dehydrogenase</fullName>
                <shortName evidence="10">P5C dehydrogenase</shortName>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="9">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
                <ecNumber evidence="9">1.2.1.88</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S009g000113</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-glutamate 5-semialdehyde + NAD(+) + H2O = L-glutamate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="9"/>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PA30"/>
    <dbReference type="STRING" id="1429867.A0A0G4PA30"/>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:L-glutamate gamma-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07123">
        <property type="entry name" value="ALDH_F4-17_P5CDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000006">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000005">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050485">
        <property type="entry name" value="Proline_metab_enzyme"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862:SF1">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 9" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="11">
        <location>
            <begin position="84"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL23173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="575" mass="62306" checksum="C2C9D991DC978C0D" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAL1</accession>
    <name>A0A0G4PAL1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BTB/POZ fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S009g000286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PAL1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PAL1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="15"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL23346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="269" mass="30600" checksum="C1EEE04566D95036" modified="2015-09-16" version="1">MESDFRRYISSPLFTFIVGDEKKEITVHSAAFSGLSQSLNVLINGDMVEAKTSRVDWPDIDVDTFARLCEFAYCRNYTPPSFCSIDGKPPLSNAKQHEYQTRPPKHNHREIPCKAGSIWTKQLNHAFTESLVVPSLQSADSDPTFTPPQNTGPCEDFTPVFLEQAQLYVIADIYGIERLRRRVLFKLYQTLRTFKLYDTGVSSIIGFVRFIYLNTPPNYNGKLDALRNLATSYIVSVLGQIGGNECFQELLEEGSPFVSDFWNIIWRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAR0</accession>
    <name>A0A0G4PAR0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L10e/L16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S009g000341</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PAR0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PAR0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.300:FF:000002">
        <property type="entry name" value="60S ribosomal protein L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018255">
        <property type="entry name" value="Ribosomal_uL16_CS_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001197">
        <property type="entry name" value="Ribosomal_uL16_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003239">
        <property type="entry name" value="PRK04199.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00279">
        <property type="entry name" value="uL16_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11726">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005590">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01257">
        <property type="entry name" value="RIBOSOMAL_L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL23401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="221" mass="25373" checksum="C037CCE1F4F82FCD" modified="2015-09-16" version="1">MARRPARCYRYCKNKPYPKSRFNRGVPDPKIRIFDLGRKKANVDDFPMCIHLVSNEYEQLSSEALEAARICANKYLVKIAGKEGFHLRVRVHPFHVVRINKMLSCAGADRLQTGMRGAFGKPQGLVARVNIGQIILSVRTRDAHRATALEALRRSQYKFPGRQKIIVSKNWGFTPVRREEYLQLRQEGKLLQDGAYVQFLRGHGSVEKNMKRFPVAYENAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAR4</accession>
    <name>A0A0G4PAR4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Oligopeptide transporter OPT superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S009g000330</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PAR4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="631"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="670"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="707"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL23390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="754" mass="85507" checksum="9D800F9588FEADFE" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PB90</accession>
    <name>A0A0G4PB90_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PDK0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF9">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
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        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="2">
        <location>
            <begin position="3"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="99"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL24386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="451" mass="50575" checksum="665ECA9F4A223015" modified="2015-09-16" version="1">MNVFKVWMRWRPLNPSEAETGEIQREYDQHHNNLQSCISVTSPLQAKALSTREKSWKSGFSFDGIIECGDNNHLVFNRVVAPIIPQVLEGKSCNFFAYGHSGSGKSHTMIGYDFERSDEFGLCLAAARQLSAALEDINVEDSNHQFGIGLRVFELRKNVAFDLLNGRNECFVREGSDGRVYIRGETEMLENGKVRVRPIATKACWSFKELQRELQKGLKHRKTATSTVHDQSSRTHAVIELEIITKDLLNARDQVVERQSELVPVGKHATDVYIEEQYRAIVQTEEGKFVPNPDYQVDQARVDAAEAKKAEYEVRVKKAEEHESGVFATTARTHRCIGGKLVFLDLAGAEFLSSTTGSALKQTPQEKQEGRQINTDLLALKEVIRARSSKKSRIPYRSSPLTMVLREHFEASTDTHSAMILTVSPEASQYTATTNTLKYGDLVGLANGHKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-11-27" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDZ1</accession>
    <name>A0A0G4PDZ1_PENC3</name>
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        <submittedName>
            <fullName evidence="8">Protease inhibitor I4, serpin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S012g000073</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF21">
        <property type="entry name" value="REGULATORY PROTEIN LEU3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="40"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL24464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="756" mass="84692" checksum="87AC0F9092BD40DF" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PEC4</accession>
    <name>A0A0G4PEC4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S012g000226</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PEC4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PEC4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF4">
        <property type="entry name" value="METALLOPHOSPHOESTERASE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="514"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="626"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="7">
        <location>
            <begin position="119"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="570"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL24616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="648" mass="73061" checksum="DC1867DA574AB068" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PED7</accession>
    <name>A0A0G4PED7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S012g000234</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PED7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PED7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL24624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="219" mass="24549" checksum="B3B7DE3DB30D3D14" modified="2015-09-16" version="1">MDRAAILRSLKSGVHVWSSTILLRCLDKDLPLESGGMQYTSRVTFQPHSYYGGPPSNKTDEIWKRLSPPGDGIVELPIAAAKNLPESLPAPNNPETALVYGVSVFHQLHCLNFLRFAYYPSSVKDMDEEEVAFHRDHCLDYIRQVLMCHADPTFEPMSEVGINGMGATHQCRDFDKIFSWAYEHRSNKVRGSGYTGGRLTHTPADLNHFDEGPHTGHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PEE2</accession>
    <name>A0A0G4PEE2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sugar/inositol transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S012g000239</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PEE2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF14">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="81"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL24629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="590" mass="65509" checksum="FB5C694DFE65B67C" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PEH7</accession>
    <name>A0A0G4PEH7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAS1 domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S012g000348</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PEH7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PEH7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040200">
        <property type="entry name" value="Mug57-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28156">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YDR262W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28156:SF1">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YDR262W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="96"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL24738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="249" mass="27935" checksum="DBABB12CDA3673B7" modified="2015-09-16" version="1">MDVVRPASLSGVIGSKMAPTRSMGFNRLTTSILFTFILASSTSALWGLSYPFPSRQQPLALEHKEHRSIMDKILPGIVQPQKTAPDEDVNSKYSGSPIISDVLPKTKGINIFARLTRDFEPVSNRLNDASKNITVLAPRNSAIQALPRKPWENPEDYKKFGEVNAYEGQDGQDRAKRNLQRFVEAHLIPASPWRVGEEVETLAGEKLKWTKEGDKIFIQPGNIEVDSIAEKVHNGEVWILNDVINYRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PEK9</accession>
    <name>A0A0G4PEK9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S013g000008</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
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    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
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    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0000981">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053230">
        <property type="entry name" value="Trans_reg_galc"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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        </source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGA4</accession>
    <name>A0A0G4PGA4_PENC3</name>
    <protein>
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            <dbReference type="PubMed" id="24407037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="107" mass="12283" checksum="C07AF67695F00267" modified="2015-09-16" version="1">MADTPQRREDARRLLYTWKDCFARSRLCSLLSGRRSVGNLPASFIRNGAAASPTLITATLFQFRGRRNGFAQYDRHRLSGCWGFHQPTPAIPRDTVDKNNRQDLCRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PGF3</accession>
    <name>A0A0G4PGF3_PENC3</name>
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            <fullName evidence="8">Archaeal translation initiation factor aIF-2, beta subunit</fullName>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <sequence length="413" mass="45932" checksum="7EC580C06E1C745F" modified="2015-09-16" version="1">MATVNIRRDITDPFYRYKMEKLQAKVEGKGNGIKTVVVNLNSVAQSLSRPPAYLIKYFGFELGAQANAKPSDERWIINGSHDAPKLQDYLDGFISKFVLCKKCKNPETDVFIKDEKITLDCKACGQRSDVDPRLKLSTFIVRNNPKGGKKEKKKSRREREKEKAANGEDASPGDSNNSENGEDGDYALEANSDDEVTRQAQAIEAEAEIKDDEWAVDVSEEAVKARAKDLPSDLKRALVIEDGDDEGADGPSSYEQLGSWIVDTAAEKGGVTKVTDVEIYMKAKEFGIETKHKTCAVLAQSIFDEKIAKQIEGRAGLLKKLITSDRHEKAFLGGTERFVGQDHPELVAQIPAILLGYYQNDLVSEETLKAWGAKTSKKYVDISTSKKIHKAAKPFIEWLENAESDEESEEESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PHA0</accession>
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        <submittedName>
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        </submittedName>
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    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793149">
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    </dbReference>
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        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL25755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="142" mass="16805" checksum="C150DE783F8C0F0D" modified="2015-09-16" version="1">MSNREQLRSPYQRTFQKECRAFVKRAEATADHARKYPNNHELEPNNGVYKGIISLLWRIARVKDTGLDMVAETPRCSLVLKQRSYWFIRDLADQTEFEDECDDIEARLEGLKQKVQRREIENLWVAGFLESTALRIQDQFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PHC6</accession>
    <name>A0A0G4PHC6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Bifunctional regulatory protein Ada</fullName>
        </submittedName>
    </protein>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
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            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.10.10">
        <property type="entry name" value="DNA Methylphosphotriester Repair Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ada-like_dom_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="7">
        <location>
            <begin position="107"/>
            <end position="150"/>
        </location>
    </feature>
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        <location>
            <begin position="154"/>
            <end position="185"/>
        </location>
    </feature>
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            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL25657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="242" mass="26198" checksum="91D8AB8BE3ED892D" modified="2015-09-16" version="1">MTDPSKPQEIPRLSRNFTNTERWQAIATRDVTANGFVYAVLTTKIYCRPSCPARLARRANVQFYDTPLQAEKAGFRSCKRCRPHSGQTAAQSNPQTATIDKACESIRNILTTGLKPKLRDLAAEAGLTPSHFHRVFKKHVGVTPGQYAESLVQSNLHSPESSLSDGVSGVETPRSASGDRGGPILDLDWDGEKGGGLSAAGGEIPFMSGWNEFDALLASELASESEQTWVPGLSIDPRMILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PHM7</accession>
    <name>A0A0G4PHM7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S016g000059</name>
    </gene>
    <organism evidence="3 4">
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793149">
        <property type="protein sequence ID" value="CRL25778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PHM7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PHM7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039254">
        <property type="entry name" value="Rds1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38705">
        <property type="entry name" value="PROTEIN RDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38705:SF1">
        <property type="entry name" value="PROTEIN RDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195678" evidence="2">
        <location>
            <begin position="21"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL25778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="550" mass="59069" checksum="16EE6E83AA0D7FE6" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PIH3</accession>
    <name>A0A0G4PIH3_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCAMFM013_S017g000198</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIM8-TIM13 complex is non essential and only mediates the import of few proteins, while the predominant TIM9-TIM10 70 kDa complex is crucial and mediates the import of much more proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterohexamer; composed of 3 copies of TIM8 and 3 copies of TIM13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIM22 and TIM54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Peripheral membrane protein</topology>
            <orientation evidence="1 14">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="14">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793150">
        <property type="protein sequence ID" value="CRL26215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PIH3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PIH3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042719">
        <property type="term" value="C:mitochondrial intermembrane space chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.810:FF:000001">
        <property type="entry name" value="mitochondrial import inner membrane translocase subunit TIM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="15">
        <location>
            <begin position="26"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CRL26215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="120" mass="12464" checksum="E943B5C5C9060CBF" modified="2015-09-16" version="1">MSSLFGSGSAAPPQTSEEIKAAVMRQLQQEAAMSNARSLIGKINKHCFKACVPTPGASLSAKENTCLSSCMEKYIAMWNTTSKTYIARVGVETKRMGGQDAAAIASMATGMPEGGSGILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PIM1</accession>
    <name>A0A0G4PIM1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S017g000004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793150">
        <property type="protein sequence ID" value="CRL26021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PIM1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PIM1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF3">
        <property type="entry name" value="CHAIN DEHYDROGENASE (ATSC), PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL26021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="271" mass="28801" checksum="36D21F1032E2598C" modified="2015-09-16" version="1">MPSYVITGASRGIGWELLRQLSSDSSNTIIGIVRNKPATQEKAKEELPERTNIHIVQADITDYTALKAAAAETATITGGGLDYLIANAGLVPTFDAYDPIGVLGEQPEALEENLIKCFKINTVSNIHLFNLFMPLILKGDVKKVIAISSGHASLDAISNLEIEVAPLYTISKAGLNAAVAKFSAQYAKDGVLFMSICPGMVDTGHFANATEEQLKGLAGMLGAFARYAPNFKGPSPPETAVQDVLSVMEKASVKGGDGGTFVSHYGNQQWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PK57</accession>
    <name>A0A0G4PK57_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GPI inositol-deacylase</fullName>
            <ecNumber evidence="12">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCAMFM013_S018g000244</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the GPI inositol-deacylase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="12"/>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PK57"/>
    <dbReference type="STRING" id="1429867.A0A0G4PK57"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050185">
        <property type="term" value="F:phosphatidylinositol deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006505">
        <property type="term" value="P:GPI anchor metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000056">
        <property type="entry name" value="GPI inositol-deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-ab_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039529">
        <property type="entry name" value="PGAP1/BST1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056824">
        <property type="entry name" value="PGAP1_TMD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495:SF7">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495">
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            <end position="881"/>
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            <begin position="927"/>
            <end position="958"/>
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            <begin position="979"/>
            <end position="1001"/>
        </location>
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        <location>
            <begin position="1021"/>
            <end position="1038"/>
        </location>
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        <location>
            <begin position="1045"/>
            <end position="1063"/>
        </location>
    </feature>
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        <location>
            <begin position="1069"/>
            <end position="1089"/>
        </location>
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        <location>
            <begin position="181"/>
            <end position="425"/>
        </location>
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        <location>
            <begin position="770"/>
            <end position="1086"/>
        </location>
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            <begin position="1"/>
            <end position="97"/>
        </location>
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            <begin position="19"/>
            <end position="31"/>
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            <end position="70"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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            <dbReference type="EMBL" id="CRL26738.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <dbReference type="PubMed" id="24407037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        <source>
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        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL27012.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="694" mass="75970" checksum="04FD2AF532B964F9" modified="2015-09-16" version="1"> </sequence>
</entry>
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    <accession>A0A0G4PLL7</accession>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
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                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793153">
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL27051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="75" mass="8477" checksum="084F99AA2F865D03" modified="2015-09-16" version="1">MSIAITPTTKHPTTEITIDDHRKREEMSAISGSYLEPSKPDLRNRARTSNTSTRHSLDRQPIPVQYAARSKQGPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PLP3</accession>
    <name>A0A0G4PLP3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl transferase, family 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S021g000003</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793154">
        <property type="protein sequence ID" value="CRL27088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PLP3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PLP3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF2">
        <property type="entry name" value="MANNOSYLTRANSFERASE KTR5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL27088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="204" mass="24093" checksum="929844A87145DD41" modified="2015-09-16" version="1">MIPHSSLRRPGKRVQHRSCPLIIALILTLIATAFFLPRLFWNGLPSNLFLPADTPPTIKIISDKHDKVFATGCLSVTYEIQRSARMNAAFVVLVRNQELDGILQSIRSIERHFNQWFHYPYVFLNDADFDEEFKAKIKRHVSAPVEFGKVESTLWDFPDWVDPEIAREGIQKQVQRQFYKHPLLLKYEWYWRLEPEIKYFCDIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PLS0</accession>
    <name>A0A0G4PLS0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S021g000046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793154">
        <property type="protein sequence ID" value="CRL27131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PLS0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PLS0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024527">
        <property type="entry name" value="Eisosome1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28298">
        <property type="entry name" value="EISOSOME PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28298:SF1">
        <property type="entry name" value="EISOSOME PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12757">
        <property type="entry name" value="Eisosome1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="708"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="768"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="768"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="827"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="849"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL27131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="860" mass="93359" checksum="12F0709FE397E738" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PLW0</accession>
    <name>A0A0G4PLW0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S022g000080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793155">
        <property type="protein sequence ID" value="CRL27400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PLW0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL27400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="347" mass="38548" checksum="E3DCA110C8685426" modified="2015-09-16" version="1">MNKAETHDPKGLSQLCASFDEGGGVALGDAFAIYSIVASSPDRSTTSSESRFQAELISAASAVGNVIPVLVTTENVFTVNIVSLPCLKHPPFNPAREISPHDNLPWFLINASKFSKHQIVGRKDIVESLLMILQRPWCVLELCCCDSLAISAIHQFAVIATKLNPELYNHALVLLHQELRRRTIPSVGDIKLYELSLITPWISFAELDTICFPIKEVYKELSSSRLRSHNSFWLRLISTCAPCLGISCSHLVRILSNMTSTGVNFSEQRHTTNQPYYSNIGRMSHHCQGSVTISTLKSVLSTRRSSLSLMDHDKRLAVNDLEILSSGLQFLLLIYRQVLQTISESLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PM44</accession>
    <name>A0A0G4PM44_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S022g000084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793155">
        <property type="protein sequence ID" value="CRL27404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PM44"/>
    <dbReference type="STRING" id="1429867.A0A0G4PM44"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021842">
        <property type="entry name" value="DUF3435"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535:SF2">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535">
        <property type="entry name" value="FLUG DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11917">
        <property type="entry name" value="DUF3435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL27404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="241" mass="27705" checksum="7C68A85C9480ED8B" modified="2015-09-16" version="1">MSSHGSVPSDESDTTPGHSEVFSDHASDTDSSTEPSVFDSSSECEDEPEDELVSEDEEEQLPPEYYLHEAESLDVSQLRQKRYSPNTQRSLDDTQYFWDQFCKGMKRDPVEYLSWLSDTEETVRFLKALFSWRCDQRRGKDRRHTAGHLIYKAEVGYGVSKDVYVKIRDVLAIVATEKSLSLKGRPKVTIYVEDVAEFARVVLSTTEMTFLYSWYRIQLLLFCQLAAITGNRPGVLLKLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PML1</accession>
    <name>A0A0G4PML1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S023g000140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793156">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
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            <begin position="20"/>
            <end position="440"/>
        </location>
    </feature>
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            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="338"/>
            <end position="365"/>
        </location>
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        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="91"/>
            <end position="113"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL27682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="440" mass="50040" checksum="4B36AB24968FA62C" modified="2015-09-16" version="1">MLTLLCLLFLLPVEYGVSASTGLRSWQLDTNNRSTWDIVSEAREQIMCVRTWLIALLVPELILGFGFLELFNVINSRARYNVVQAEAKSRRQARSGSHGGLRNEPFDGAQENPDSAKWTFTQTFCINAGGLALQTQDDWIYTVTCEDEMVLLIQSGMVSPLDLRERDIQEHAKQDWLGKLFTLLQVSWFICNIITRWASHVSVSPFKLATVAYCFLGIVIYGFWWFKPKDMGAPIIVPLHYDRDNLPGELHDAMHSAGWTHRLAPLKEERILLIAWDAMKTPFLSEDGEDLELLKERPVETPSWIIHIVVILFGLTGLSYCGIHIAAWDYTFPTRAEWISWIVFCFTAVAGVCIFSTVNTAYLALLHLKVAKKLPSSMEFLVEDTHWQRIFDTHMYIKQAGISLYIIARLGIMALVCSSLRALPEDSYTTVGWVTSIPHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-11-27" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PML4</accession>
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            <fullName evidence="8">Nuclear pore complex subunit Nup192</fullName>
        </recommendedName>
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    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1665" mass="185767" checksum="1E12CCD27FC485F1" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PN69</accession>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="9"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="CRL27623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="199" mass="23585" checksum="A093A0FB1E2FBBEC" modified="2015-09-16" version="1">MDLFRSNRLEYRSFNSPEDDDFFHSIQSDPVAFTNSCASLIRPVDRQFTENIKKHLIENSLLFVVIYKITDNSGTQIEPERIGTLFLKSPSPDMAHHRCSEFGIDIKKEYQTQRYGGEAIDWMLDWAFKNAGLHRVECNVFGWNTRAHKVYQKFGFQEEGRRRECLFKDDKWWDEVHLGILKNEWQRIRRVQATTPTFA</sequence>
</entry>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
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                <person name="Silar P."/>
                <person name="Lacoste S."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793158">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="CRL28080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="110" mass="11758" checksum="57487A4E996B2A90" modified="2015-09-16" version="1">MQSLRSSGTDSPQWPSVDAVRISKADVSAYQKECIYQEVPAAVNALRVVGIVWIDSGTHNVLYHENDLKLCNGEGLVNQPEMTAIFGLEAVSGTKKSPTILTRLGGGDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNZ9</accession>
    <name>A0A0G4PNZ9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S025g000173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as a protein folding chaperone for elongation factor 1-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZPR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793159">
        <property type="protein sequence ID" value="CRL28221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PPY2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000002">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1040:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1040">
        <property type="entry name" value="ZPR1, A/B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.420">
        <property type="entry name" value="ZPR1, zinc finger domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004457">
        <property type="entry name" value="Znf_ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040141">
        <property type="entry name" value="ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042451">
        <property type="entry name" value="ZPR1_A/B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056180">
        <property type="entry name" value="ZPR1_jr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042452">
        <property type="entry name" value="ZPR1_Znf1/2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00310">
        <property type="entry name" value="ZPR1_znf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22794">
        <property type="entry name" value="jr-ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03367">
        <property type="entry name" value="Zn_ribbon_ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00709">
        <property type="entry name" value="Zpr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="10">
        <location>
            <begin position="38"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="10">
        <location>
            <begin position="260"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="438"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL28221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="479" mass="53121" checksum="743E65F8C79E3635" modified="2015-09-16" version="1">MVSKADNDALEAQFESQFQKPGDLVERDDDTGAMTIESLCMNCHEQGVTRLLLLRVPYFRDIILESFECEHCHLKNNSIKSAGQIQERGTVYTLRVENEEDLQRQVIRSDVSGFKLTTKLGNEIEVPKGTGQLTNVEGMVQLIHENLSGEQDLRKDQAPELYAALVPIIDSLEKIMSREDAFPFTITLDDLTGNSWIAPNSNDRGNKYKRHEYPRTHEQNEELGISADANAVNQEDTAQVEAGDPDDLDIVDGQVYTIPAECPGCNKEAEVNIKKVNIPYFKEVLLFGTNCGHCGYKSSAIKTGGEVPEKGKRVTLQVDNEVDLSRDILKSDTAGLYSPELDLDVQPGTLGGRFTTVEGLLVEIRDQLKGAIFDVDDSTRSGGDSMVSSDKDKWQRFFSRLDQAISGELKFAITLQDPMASSYVQDLCSPAIDHQITTEDYTRSAEEEDDLGLTDMKTEGYEEAQAQADAAKADAAQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPY8</accession>
    <name>A0A0G4PPY8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Heat shock protein Hsp70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S028g000045</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793161">
        <property type="protein sequence ID" value="CRL28492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PPY8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PPY8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034663">
        <property type="term" value="C:endoplasmic reticulum chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10230">
        <property type="entry name" value="ASKHA_NBD_HSP70_HYOU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000039">
        <property type="entry name" value="Hsp70 family chaperone Lhs1/Orp150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF3">
        <property type="entry name" value="HYPOXIA UP-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0346">Stress response</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195858" evidence="7">
        <location>
            <begin position="36"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="604"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="824"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="946"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="792"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="630"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="646"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="824"/>
            <end position="848"/>
        </location>
    </feature>
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        <location>
            <begin position="850"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="861"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="949"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="968"/>
            <end position="994"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL28492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="994" mass="108286" checksum="6C714EB625C43391" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQH8</accession>
    <name>A0A0G4PQH8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S029g000065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793162">
        <property type="protein sequence ID" value="CRL28649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQH8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL28649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="110" mass="12352" checksum="FF6A065755CB3B61" modified="2015-09-16" version="1">MIHAQVGSSLVSRHYPAILLAVFREEPNQDSEDRCIPRVDHCDTFGFELRLPPQLPGPRRSRDQANCDQSPLGGPFSASDHQNHTMFVDYMIQEDRAVVTLCSGPVYSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQL2</accession>
    <name>A0A0G4PQL2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S030g000039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793163">
        <property type="protein sequence ID" value="CRL28752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQL2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL28752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="120" mass="12704" checksum="CB8EE28EC2C0BECF" modified="2015-09-16" version="1">MRYSPLLCLQFLKDEDEHDASLLGLIINGAGNIAIYVDASTTIDALFLLIPDKYAHSWTSFALADPLYTDLLPVGIRLYGMAVPASTAAAASTSPCAHSILSACVSALLLLSSHCLPPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQN2</accession>
    <name>A0A0G4PQN2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S027g000125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793160">
        <property type="protein sequence ID" value="CRL28436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQN2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PQN2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053065">
        <property type="entry name" value="Archenteron_Induction-Rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024382">
        <property type="entry name" value="Vps3844_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36853:SF1">
        <property type="entry name" value="DUF3844 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36853">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12955">
        <property type="entry name" value="Vps3844_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195538" evidence="2">
        <location>
            <begin position="19"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar sorting protein Vps3844 C-terminal" evidence="3">
        <location>
            <begin position="297"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL28436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="412" mass="43580" checksum="460CA0A03F579B04" modified="2015-09-16" version="1">MHWVSGFLALALTGALQANALDATIFTFPSKTATSLSGSPQQQTISEDEARLVLELRMKSSVASVLGMVDADTVHHLNQFAQDDFTLFGGATGGIGLKKSVFILEGVDQEVAMQKAQPNHLHIPQISSPFIGFDLLESFVESSPTAKGDHGQTCTYFNNASRAASSTSQTPKECLSRDPMFADASDLLSRDSLPLIDSMESWISKDHKDSALKLSFKNASGDSLLRTKLLERLLLRLAKMASTNNREITTVVLPPGVKSGGLSRQGVKPSSAPVTQQNAFRRSVQNSALRSTLAPVCHASNSSCAESTNNCSGHGSCYLKYGSGVEGTTGNCYACQCKQSVVQNSDGTTKTIQWGGSACQKKDISSPFFLVAGVSLLAIILVGSAIGMLFSMGSQELPSVISAGVGGPKSQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRD9</accession>
    <name>A0A0G4PRD9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Galactosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S030g000015</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793163">
        <property type="protein sequence ID" value="CRL28728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PRD9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PRD9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000149">
        <property type="entry name" value="Alpha-1,6-mannosyltransferase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF10">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL28728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="318" mass="35897" checksum="D7E62EF00C6A9757" modified="2015-09-16" version="1">MQFALPPRRSPHPVPLARSSRMSSYRRKQLKSAAVLALAILSLIYLLRYLYSSASTSVVAPVGTSGVVIVTLLDRQRYSDSYLKKIVANREDYAKRHGYTNFFASASDYDEAVGDAQMSWAVAPAMRHAMATHPHSAYFFHLATNALIMNPTKSLKSHILEKGRLDDLMMRDVPIVPPDSIIKTFAHQEEKDVDLILTQDSENLNPGSFILKNGEYARFFLDAWFDPLYRNYNFAKAETHGLDHIMQWHPTVLARAALVPQRILGSYSHASPGASLDGTYKDGDLVIQFHGCEDTEGRDCAHELEPYYKIWEKKTQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PS77</accession>
    <name>A0A0G4PS77_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S035g000014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793168">
        <property type="protein sequence ID" value="CRL29319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PS77"/>
    <dbReference type="STRING" id="1429867.A0A0G4PS77"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL29319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="459" mass="51321" checksum="C3031F51209EDBCE" modified="2015-09-16" version="1">MPVISAEVALFFQDGGLLGPATNGKRTISVTALSSPVTSRSTSSSNTIDRTSFSATFVNVPQDEIELPQELKSRETYEFIGFNEETASKLWDQYLNRPINDPLDPFDFDFMDYARSQVRNHTVPDVLSITDDWTPTMTTLGISQCLQLSILHPDFDDVRATASCKFWLLDSIEMAFKTLEGMNGQLRQEMERRQQLAVLSGRERSPPPSLPAPISRKGSLKSTTKETIVPSKGPAAFKDTTALDKGPVAGVTEQEAPARLPGHTMIWRACLLSEAVECCESRLQELDFKSISSSPGDFGGRTAVAYFSPQRETADRYAMYKKHRFSIAELAILQVAVPDSLVQSLSINYLWADGAESQLWKKVIWHCRRGQRLPKDLRYMGNKDLWIGHIAKSTNSSFATTESYTQIQSPDVLAVQVNGEWRNAIQWVFYSDHAEELFAQCCKGKTWIHSIGKLVEASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PSW4</accession>
    <name>A0A0G4PSW4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S034g000036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793167">
        <property type="protein sequence ID" value="CRL29238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PSW4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051531">
        <property type="entry name" value="N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792">
        <property type="entry name" value="GNAT FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00765)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792:SF16">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="69"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL29238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="240" mass="26986" checksum="82BC624F396C30C5" modified="2015-09-16" version="1">MGSDNGESVEQFAILTPRLIIVPTPTAVSFKSYRALYSDLHANVDFCQMGFGHHFPARVWSDEETRNGIQTRDIERCWQRRGLGDFAVGLRGPSTFEPDNHPTQNGDFVTLKGDDYVRVAGLNNIHIAASEWVGYAGLRDATTTSMPPREPGDPALPSWVEMIELRYGVSPKFWGQGIAQEASKAIMRWSVDERGVKRFIAETERDNSRSGNLLQKLGFTLSDTNYWKEPSELEWECAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PTD1</accession>
    <name>A0A0G4PTD1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rare lipoprotein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S035g000046</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793168">
        <property type="protein sequence ID" value="CRL29351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PTD1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PTD1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195958" evidence="3">
        <location>
            <begin position="26"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL29351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="158" mass="17484" checksum="A4A0822F0BA04F3A" modified="2015-09-16" version="1">MIYNAIFKCKAIAMIAFLFTGLTVGAPLDPHENTTSHALSNPSQWNNTHSPGAEHALGGDLTWYETGVGACGWWNNAWDHVCAVSHIVYDRANVDGNPNHNPLCGRLIHIQRGDRGVDVTLVDRCEGCGEFDIDVSRGAFQVLGNLDEGRVHTEWWWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PTZ9</accession>
    <name>A0A0G4PTZ9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beta-lactamase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S040g000079</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793173">
        <property type="protein sequence ID" value="CRL29853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PTZ9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PTZ9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07729">
        <property type="entry name" value="AHL_lactonase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF2">
        <property type="entry name" value="102 KBASES UNSTABLE REGION: FROM 1 TO 119443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="6">
        <location>
            <begin position="61"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL29853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="290" mass="32569" checksum="BC3388EC9A1E54A9" modified="2015-09-16" version="1">MAAPVHQIIPAVIPAFACPEGTKMHILNLGTLTVDEGWLLNGANGGSASNPNPIHKRRDLMLIAGLIYHPEMGLILFECGSTEDIDAQWSSEATDLFPRTCYTQSHHLPEAIKAAGYDIKDVQAVIMGHLHLDHAGGLEHFRNTNVPIYVHEEEFKHACWAAGTNSDGGLYLAEYLKLDGTLNWQTFNESQLDLCTGLTLYHCPGHTPGLCIMQINLAKDGTFIWTTDQYHVRENFEDNWAHGWLLRDYRSWVDSGKFIRRLQRVFSATLIFGHDYGVAEELIGRKAYHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PU56</accession>
    <name>A0A0G4PU56_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S043g000035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793176">
        <property type="protein sequence ID" value="CRL30040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PU56"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL30040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="310" mass="34142" checksum="A8AF75E8E28E8F82" modified="2015-09-16" version="1">MPTMDFANEILESVSSATSFEVLREDGAIDDKKNHFQRPTSQSNKNIPDELNNPTYQKIMPPTSREEPTMAYMSPVSSEQKLVSVKASNALSPAKEQVRQGTVAVSTLPRVDVTPTVNHEYLQDISPTWVVSGIWRIPKTPGTPLSHTNTIIPGSIHRNQQGTTSDFRWRSVSIKSMEQEIKSTPILRSPSSLLATDTSASMHYEESPGLGDTQTSPTNILPTSSTPDSKPSNGDDLIVSGNKGPHYSRTQSLGIILGSVSGASIIIFCGIILLHRPCYRRFRESRKTTIWIAHVSQNRDDAQPEDTDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PU66</accession>
    <name>A0A0G4PU66_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S043g000045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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</entry>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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        </source>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        <location>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="430" mass="48828" checksum="4B5A9223BB7005A1" modified="2015-09-16" version="1">MPEIARISILMSSGKELSFNKMLLFVDDLKAHCERDFGVAYLPRESPIQGRCPARGCLEEIKHLKKPHRSAHIHNCIRLIRPSYCPFCLWDMDLDAEDRLYQWSKSGNLKQHIEEKHMLGDQGSGAKPTCGCGQAFADERGLRHHLHDTHKLNKAIWLNPKLPRKRKRTCKVEPQVSSMELEERPKRRRERYYSSELRDTSSESSRSSSVISYFSATDSSLTSPPTTPGSDVIDPAILKPIGLNMEDGCQPYNQVPIQLDSPDLSMDEPETKKEPFTCPKLAKRSSEDCAGNEASERPSKALRPDSLISPSDQRPKPRREEHHNTLAGSNNKALCGDQAGVPLTRAKSRPQPPLNNPGGSSTRKARQKLNTQEKRKLLELKGQKMTLRQIGPLFADIDTTFLRQSWEDMELPQRCTRSRANRTDRRVYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVQ8</accession>
    <name>A0A0G4PVQ8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S055g000006</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793188">
        <property type="protein sequence ID" value="CRL30591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PVQ8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PVQ8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008793">
        <property type="term" value="F:aromatic-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF21">
        <property type="entry name" value="AROMATIC_AMINOADIPATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL30591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="102" mass="11499" checksum="B82E6E07F6518C05" modified="2015-09-16" version="1">MTPCFAHRALLSHLRLDADGRVLRMDSFSTIIAPGARMGWVTASEQVIERIVRKWVAIYSCEGVNSIAAAKHPGYSVSLWNNINKWIGMNHRAIFQTQSTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVV3</accession>
    <name>A0A0G4PVV3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S048g000016</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793181">
        <property type="protein sequence ID" value="CRL30304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PVV3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58100">
        <property type="entry name" value="Bacterial hemolysins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="485"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="104"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="491"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL30304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="519" mass="58365" checksum="851F686AE3A2207A" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PWE5</accession>
    <name>A0A0G4PWE5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S056g000040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793189">
        <property type="protein sequence ID" value="CRL30667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PWE5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PWE5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL30667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="278" mass="30229" checksum="A40EAF0917B0158B" modified="2015-09-16" version="1">MAKVALITGGTSGIGLAVAKDLIQTGSWQVNVVGSNQERGQDAAASLPNVTFYQADVRNYQQLAGVFDQIFNATGRIDFVFANAGRAEYTDFFAKSETSIPPEPGSEIVDINLNGALYTSYLAMHYFSRSPESTKGHRNLILTSSIGGLYPCMLTPVYSSTKHALIGFTRSVGEKLWEEGVRVNALCPGVVETPLLDDETFYAIFPREIFIALDVVTGVVSQLLSGADMVDARGIRVAGDEMHSRAVHVSGKSFLFIEKPEIHDEQTQITWAAMMGHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PX40</accession>
    <name>A0A0G4PX40_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S062g000007</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793195">
        <property type="protein sequence ID" value="CRL30868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PX40"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
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    </dbReference>
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    </dbReference>
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            <end position="69"/>
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        <location>
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        </location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
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        </location>
    </feature>
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            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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        </location>
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            <end position="534"/>
        </location>
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            <end position="503"/>
        </location>
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        </location>
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        <source>
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    </evidence>
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    </evidence>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
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    </evidence>
    <sequence length="555" mass="59880" checksum="A4A803152D754073" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
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        </lineage>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
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    </reference>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="346" mass="38607" checksum="C9FD0B64DDCFE1CC" modified="2015-09-16" version="1">MDTLMTSLPPNVGAILMENISIIQIVSMFSIGAYNALETAIVTFDSFKRYRGLYFWSMQFASWGILVHAIPAMARFISQASNLPTSIPFMIGWYAMVTGQAVVLYSRLHLVFSDMRKVRWVLWMIITNACILHIPMTVFFFGLNRGDARFARPAAIFDRIQSTSAITIRGRDGRNAIIHLFCINILVVILNVLLLLAEYKLHYIQVSFKTVVYSVKLKLEFSVLNRLRLLTSTNPCICQNGPEDSRRSNDKNIFGMASSRPVIAPDVSSQSGATQTDMPRSLRPSSIYGYDETLRETSSENMMPPGDVYSSATLSEGHSNTLPGGSSETLPALELSLSQFSPKFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
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                <person name="Silar P."/>
                <person name="Lacoste S."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
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    </comment>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS_Azr1_MDR_like"/>
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF199">
        <property type="entry name" value="MFS EFFLUX TRANSPORTER INPD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
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    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="55"/>
        </location>
    </feature>
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            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="123"/>
        </location>
    </feature>
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            <end position="156"/>
        </location>
    </feature>
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            <end position="185"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
    </feature>
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        <location>
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            <end position="477"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="449"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL17321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="486" mass="51553" checksum="B3661017E4E8CAA1" modified="2015-09-16" version="1">MSGIEKHPPAEENMVNDKEAHNFYPMGTKLILITVSLMLAVFCVALDNTIMAVAIPRITDDFHALNDVGWYASSYLLTTCSLFLFELGSLICGIAPNSTTLIVGRAVAGLGSAGIFTGAPVTLAHTVELEKRPIFFIMLGGMYGIASVAGPLLGGAFTDHATWRWCFYINLPLGGITAIGLLTCLKLPPSAQSQKTTMDIFLQLDPLGTVIFVPAIVCLLLALQWGGVTYDWSNGRIIALFVVFGIAIVAFVALQIILGDKATVPTDIARQRTIAFASFFGLSIRGVTAVRSGIDSLPMILSNVIGIVVSGGLTTRLGYNAPFFIASSIIMSVGAGLIATFTVDVSQAKWVGFLFLYGLGVGFGFQQGPIAAQAVLPLPKVSIGTSIVMFLQMLGGSLFVSVEQNIFTKELISNLAALDIPDFSPSDVVNGGATSIRSVVSESVLPEVLVAYNDALLKVFQIALIMGCLSIIGALGIEWKSMKPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NU16</accession>
    <name>A0A0G4NU16_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S001g000531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NU16"/>
    <dbReference type="STRING" id="1429867.A0A0G4NU16"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43328">
        <property type="entry name" value="ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43328:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="168"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL17571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="262" mass="29650" checksum="BCA0B16E1A61380E" modified="2015-09-16" version="1">MVVHYNPLTKEPYLQLPAPCANIIITPYREHQIEETSAALTETLNDSRVYSWLVGPPYPFLPEHGVDWVKMKIAENENILSTLQREFETSQSQQGGGSNGKEEPEFFDKCPFLCIREVTERDPATGAPLRDISIGEISLTRYAFYELRPDNPELALAQKQNNDLPAGHKDIIWGIGYYLSPTQQSRGVMSVAVRTVIQDWAIPRMNLHLLKSSFFVGNTRSSRVLEKNNFVEIGTFKDWTPANPKKGLGKMSIVVVEWKGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NU48</accession>
    <name>A0A0G4NU48_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Zinc finger, Sec23/Sec24-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PCAMFM013_S001g000572</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NU48"/>
    <dbReference type="STRING" id="1429867.A0A0G4NU48"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF4">
        <property type="entry name" value="SECRETORY 24CD, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="16">
        <location>
            <begin position="298"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="17">
        <location>
            <begin position="379"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="19">
        <location>
            <begin position="630"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="18">
        <location>
            <begin position="726"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="15">
        <location>
            <begin position="855"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="108"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CRL17612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1011" mass="109446" checksum="6C7FE77EDB9A3B29" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NUE8</accession>
    <name>A0A0G4NUE8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sugar/inositol transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S001g000658</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17698.1"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:carbohydrate:proton symporter activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
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        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
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        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF38">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SUGRTRNSPORT"/>
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        <property type="entry name" value="MFS general substrate transporter"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="15"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="509"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="524"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL17698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="538" mass="59195" checksum="D3DDF97738B1EB25" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NUQ2</accession>
    <name>A0A0G4NUQ2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kinesin, motor domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S001g000756</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:microtubule binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115:SF1008">
        <property type="entry name" value="KINESIN-LIKE PROTEIN SUBITO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="10"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="190"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="742"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="785"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
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            <begin position="636"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="714"/>
            <end position="741"/>
        </location>
    </feature>
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        <location>
            <begin position="192"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="234"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL17796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="816" mass="90849" checksum="3A37CF922A165CF5" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NV12</accession>
    <name>A0A0G4NV12_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TGS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S001g000872</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NV12"/>
    <dbReference type="STRING" id="1429867.A0A0G4NV12"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000740">
        <property type="entry name" value="Putative GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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    </evidence>
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</entry>
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    </evidence>
    <sequence length="179" mass="20534" checksum="CDB01D0C2BBFBF0B" modified="2015-09-16" version="1">MNLTLNGLSWPTKHLHTTTRNGSTWGYVIYRTTYTPHSNAAFLRIIDLLNSYMKHGLYSECVSSGNNTRLNTDLTSYHEIWAQHRSIIMNHPKFEGASVDSIRAHFRRWVDVQEDQGLSTQYHMCMVIDEESLQTLLDTPSPQECSAEKVLDPMRHVKVIPLLPNSDDEFDEFDGFMGG</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL19434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="169" mass="19431" checksum="A12A3980751538B2" modified="2015-09-16" version="1">MLQLGVYRILRIFWITLDFWFNTDQSSFPTSQVQRSGKLSESTPLEILTPLSSAPESEMSSDSIELESWEEIYKEECLSFKASLETQAQILRNDPESQGVDRIKDVRKELISLSHQAERIKEAAFEMVDETPDSVYVRNGTPEWLSSRFGDPQLEQIRPVNGPYGRRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZM9</accession>
    <name>A0A0G4NZM9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Catalase</fullName>
            <ecNumber evidence="13">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCAMFM013_S003g000316</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 14">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Alkaloid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="13"/>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZM9"/>
    <dbReference type="STRING" id="1429867.A0A0G4NZM9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08157">
        <property type="entry name" value="catalase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000001">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF26">
        <property type="entry name" value="CATALASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0017">Alkaloid metabolism</keyword>
    <keyword evidence="5 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 13" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 13" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="15">
        <location>
            <begin position="7"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CRL19525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="490" mass="54996" checksum="0C2D05A8B84D2B1B" modified="2015-09-16" version="1">MTNHTFTLAEGQPIADPSVSTTLPTFGGGGLTTLGDTLLIETLSHFNRERIPERVVHAKAAGAWGEFEVTNDISSLTSAKFLNGVGKKTPVLFRLSTTGGEKGSADTVRDVRGFSVKFFTEEGNHDIVGNHIPVFFVRDPVRFPSLNRSHKRHPATNRPDWTMFWDFHANQPESVHALMHLFGNRGIPDSIRRVTGFGVHTFKMVSADGGFRYCKFHFRPTQDITHFSGQEGTRMAGANADFHNQDLWDAIARGDLPAWKLYVQVMEPEQAETYGRALFDITKVWPHKEFPLIEVGQMTLNKNPENYFAEIEQAAFSPSNMVPGIAMTPDPMLQARMFAYPDAQRYRLGVNYTQLPPNRAICPVYAPFERDGMGTVTRNYGGDPNYVRSSLGTGVPSQTVSNVRHTERILRNAVLGQNEIPVDDEDFLQPRELWNRVFDEAERRQWVSNVSETLEDVPDQLKEAVAAMFSKVDPRIGQLLEAKAKNSSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZP5</accession>
    <name>A0A0G4NZP5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial substrate carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S003g000323</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZP5"/>
    <dbReference type="STRING" id="1429867.A0A0G4NZP5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF4">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="28"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="138"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="251"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL19532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="343" mass="37404" checksum="919F9707D43F53BD" modified="2015-09-16" version="1">MEGKAQSRYGPTEGEEQSIPVLTTKKAVSSWVHLLAGASGGMATAIVTSPLDVLRTRLQSDFYQPQNRGSDASSRPVQRSNHKTLRIINSIYRAEGWRAFFRGLGPSMAGVVPATAIKFYVYGNCKRVGAQLMGHTEDSAMVHAQAAICAGLATSTATNPIWLVKTRLQLDKTQTNTGGASTRRYRNSIDCIKQVMRTEGLGGFYRGLSASYLGSIETALHLVLYEQLKTRLNRSLEATEGPRTPFWNEVFHWVSTSGAASSAKLVAGLITYPHEVIRTRLRQAPVEHGQPKYTGLVQCFRTIAKEEGMAGLYGGLAPHMLRSLPSAIITLGVYEFVLRVTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZX5</accession>
    <name>A0A0G4NZX5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose reductase [NAD(P)H]</fullName>
            <ecNumber evidence="3">1.1.1.307</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S003g000411</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>xylitol + NAD(+) = D-xylose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>xylitol + NADP(+) = D-xylose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27445"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.307" evidence="3"/>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZX5"/>
    <dbReference type="STRING" id="1429867.A0A0G4NZX5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004032">
        <property type="term" value="F:aldose reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019568">
        <property type="term" value="P:arabinose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042843">
        <property type="term" value="P:D-xylose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042180">
        <property type="term" value="P:ketone metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000018">
        <property type="entry name" value="Glycerol dehydrogenase Gcy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="12">
        <location>
            <begin position="21"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="11">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL19620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="297" mass="33001" checksum="A1211C86FA593A56" modified="2015-09-16" version="1">MSNQHTEKTYTLNTGAKIPAIGLGTWQSKPNEVRIAVRDALLAGYRHIDTALAYGNEAEVGAGIKDSGVPRDQIWLTTKLDNPWHKRVTEGIDSSLKDLGTDYVDLYLVHWPSSTDPNDLSKHLPDWDFIKTWQEVQKLPATGKVRNIGVSNFGIKNLEKLLNDPSCKIVPAVNQIELHPNNPSPKLVAYNTSKGIHSTGYSCLGSTNSPLYKDPTLLQIAEKKGKTPQQVLLVWGIQKGWSVIPKSVSKSRIEGNFDINGWDLTADEVSQLDNLKDRFKVCGDAWLPIKVFFGDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P041</accession>
    <name>A0A0G4P041_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S003g000487</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P041"/>
    <dbReference type="STRING" id="1429867.A0A0G4P041"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF79">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL19696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="172" mass="19267" checksum="81925E5BBEBA263E" modified="2015-09-16" version="1">MEGMDHSSSSTSCQVSMMFNFNTIDACFLSTGWQIKNNGMFAATCIGTILLVVLVEFCRRIGREYDNFLTRQFERQAAHGTFAKKFESARTAVTFRATPLQQLTRSVIHAVTFAGAYITMLLAMYFNVYVIICICIGAGLGKFLCDWMVVTVGIDDVQDETRKLEETTICCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P044</accession>
    <name>A0A0G4P044_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger, C2H2-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S003g000481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P044"/>
    <dbReference type="STRING" id="1429867.A0A0G4P044"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058925">
        <property type="entry name" value="zf-C2H2_AcuF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF7">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26082">
        <property type="entry name" value="zf-C2H2_AcuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase acuF-like C2H2 type zinc-finger" evidence="2">
        <location>
            <begin position="280"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
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            <taxon>Eurotiomycetes</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4P1X5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF12">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EP450I"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL20263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="527" mass="59324" checksum="EC33E25D7988117C" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P257</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P257"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022190">
        <property type="entry name" value="DUF3716"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12511">
        <property type="entry name" value="DUF3716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL20405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="344" mass="38793" checksum="813F3A07C12A75D3" modified="2015-09-16" version="1">MEDINQIFRHRGRLTGRQTFLPPNPARGDGMRAPGPWAVHIHKLPFRVARDGDILQGSYLNALNAMPNQREPYLRPGISLTAREFQQQMNDNLPCVEAALMQVVGQQNALQCTRCLQQFGIFSQCVSVHNIGGLSACANCHWEEQDDCCQYMQPLATSPPTAGPGPMNPHQDNASTTFPQNPARNPFRSRSHTSRPDANTSGDTTTRPLQRLEIVRHLVGQTRLMRQNRDIERQLEGLRGQLTAANTATTTTDRPLQHIVDEILAAHRELHHGIWHNVYDTMQMMKSTRWTQTILVFSGIFTFIVDAYPASALAAPWPEIASRDPLLREFPPCSEKTEEVRLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2X1</accession>
    <name>A0A0G4P2X1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldehyde/histidinol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S004g000606</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4P2X1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000023">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF7">
        <property type="entry name" value="SUCCINATE SEMIALDEHYDE DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="4">
        <location>
            <begin position="27"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL20665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="499" mass="53696" checksum="F952B11BC77F7F18" modified="2015-09-16" version="1">MATQYQLPFKLADPSLLKFESIIGDKWVGAKSGKRFEVLDPGTDKAWASCPANAAEDVSAAVENAHTAFEQFRKVNPRQRGKWLLEWHNLTLAARDDLAQIVTHETGKPLAEAYGEIDYSLGFLWWFAGEAERIQGSVSTAAAPNRRLFTIKQPIGVAAALVPWNFPVAMVLRKVGAALAAGCTMVVKPSPETPISALVLAELAQRAGIPAGVLNVLTTDLENTPALSEALCKHPLIKKVTFTGSTRVGKLVASHCADGLKKLTLELGGNCPFLVFDDANLDQAVEQLMSLKWRHAGQACITANRIYVQAGVYDRFAALLKERTAAIVVGHGAVTGTTMGPLTTPRSIDKASAQVEDARRLGADVILGGNPVASKPGYFFEPTILSGMTEEMLISQEESFAPIAALYRFETEEQAVKLANDTSMGLASYAFTKNIDRMWRLLENLEAGMIGMNTGNSSAAESPFGGIKESGYGKESGKDVAVNEYLVTKTGTLTIEGQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2Y5</accession>
    <name>A0A0G4P2Y5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCAMFM013_S004g000610</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P2Y5"/>
    <dbReference type="STRING" id="1429867.A0A0G4P2Y5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11618">
        <property type="entry name" value="ChtBD1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00598">
        <property type="entry name" value="GH18_chitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000159">
        <property type="entry name" value="Class V chitinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018371">
        <property type="entry name" value="Chitin-binding_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF337">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00026">
        <property type="entry name" value="CHIT_BIND_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="4 11" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195124" description="chitinase" evidence="13">
        <location>
            <begin position="18"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="15">
        <location>
            <begin position="18"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="14">
        <location>
            <begin position="302"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="318"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CRL20669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="437" mass="47707" checksum="BF99A548C4E690C9" modified="2015-09-16" version="1">MFKRLALGLLAVQSVAATRFAMYIDEYHVTDLPSQDKTEGIDYAIMSFAASKLFNSDSPEAYKPFESPETMRKRFSPDTKLMVAIGGWGDTAGFSEGAKDEASRTRYAKNVASMLDAHGFDGVDIDWEYPGGNGQDYKDTPNSKKVGEIETYPLFLEALREAIGDKVLSIAVPGRKQDFIAFTKEQGPKIFKSVDMVNVMTYDLINRRDNVTDHASGVQNSLDTINEYLAIGADPAKLNLGFAYYAKWFTTDPDSDCDENALGCHLAKLENDDGTDNGKSGALTFEASTAAAAPKDLKDSTDGLCGFGAKAKCPSGQCCSASGYCGTTDEFCQAGCLSDYGTCKGISITDSWRKAQKDGKADAKGGGQYYFDSENNLFWTWDTPEFIARKFKEIVAEKKLGGVMAWSLGEDTYKFEHLQAMQKGIESHAPKAERGCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P377</accession>
    <name>A0A0G4P377_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S004g000732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P377"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL20790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="85" mass="9054" checksum="509A3DF38314EAAB" modified="2015-09-16" version="1">MFANGLISWFSSKESTPNTTSDATSIENNQPTSPKAPSTDRMVTEQPNSQEDMMKLRGGGAGDVCCGLCAGLLCFECCECCENCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3H9</accession>
    <name>A0A0G4P3H9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S005g000045</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL20881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P3H9"/>
    <dbReference type="STRING" id="1429867.A0A0G4P3H9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016755">
        <property type="term" value="F:aminoacyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055091">
        <property type="term" value="P:phospholipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051211">
        <property type="entry name" value="PG_lysyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34697">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL LYSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34697:SF2">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL LYSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Phosphatidylglycerol lysyltransferase C-terminal" evidence="7">
        <location>
            <begin position="168"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL20881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="546" mass="59702" checksum="2EE6357F48D49CA6" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3I4</accession>
    <name>A0A0G4P3I4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S005g000059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL20895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="192" mass="20869" checksum="CEDFA67B912CD2B0" modified="2015-09-16" version="1">MQSVAGAPRPSRLTKWWPIGFFIGAIICFVIGAALVGTWTSHSYDDCSYSSSYYSSYYSSYSCGSTNMGEFYGAVAMFVIGGVLKLIAWILLIIFCVKRSRHSHHTVTYVNSPPVQQVQQPQPFQQSYTAPQPTYAPAHQSAQFPHSPEMVNPSVPGTPPIEANATATTAKYCTQCGTAVSSRFCPQCGSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3Y8</accession>
    <name>A0A0G4P3Y8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PCAMFM013_S005g000220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
    <dbReference type="InterPro" id="IPR056444">
        <property type="entry name" value="Zn_ribbon_GRF_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23549">
        <property type="entry name" value="Zn_ribbon_GRF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRF-like zinc ribbon" evidence="1">
        <location>
            <begin position="8"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL21056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="121" mass="13978" checksum="CE5F04E0D21E4327" modified="2015-09-16" version="1">MTITRLQPPRCPKCYEDGMRLKVNDNNPNGNAGRPYYKCYPCDRFICFADQRGISPANPLCQCGEYTRRQISGTSKEVQHGIHYVCARGWCWFYEKEVDHDGVQRRVPDRSVGICASYSYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6N6</accession>
    <name>A0A0G4P6N6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RuBisCO-cytochrome methylase, RMS1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S006g000414</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1429867.A0A0G4P6N6"/>
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    </dbReference>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19178">
        <property type="entry name" value="SET_SETD6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal lysine N-methyltransferase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1420.10">
        <property type="entry name" value="Rubisco LSMT, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015353">
        <property type="entry name" value="Rubisco_LSMT_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036464">
        <property type="entry name" value="Rubisco_LSMT_subst-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044430">
        <property type="entry name" value="SETD6_SET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF34">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE SETD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09273">
        <property type="entry name" value="Rubis-subs-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81822">
        <property type="entry name" value="RuBisCo LSMT C-terminal, substrate-binding domain"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="34"/>
            <end position="281"/>
        </location>
    </feature>
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        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
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            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
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            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL21874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="487" mass="53709" checksum="B2D7B560CB9866D2" modified="2015-09-16" version="1">MSSTAHFPDAEGFQQQSDNFMSWLQASPGVQLNPKLRLADLRATGAGRGVVAQSNIPEGEELFSIPRAMVLTVQNSELRTLLGENLEEQMGPWLSLMLVMVYEYLQGEKSRWAPYFRVLPSRFDTLMFWSPAELQELQASTIVEKIGRSNAEESIRDSIAPILAKRPDLFPPPPGLASWEGDAGDAALIQVGHVMGSLIMAYAFDIEKSEDDDDEGEANDESYMTDDEEEEQLPKGMVPLADLLNADADRNNARLYQEEGALVMKAIKPIQQGEEIFNDYGEIPRADLLRRYGYVTDNYAVYDVLELSLETICEAAGLANADPESQPRLEFLSSLDILEDGYVIPRPVNANPSLEDILPAELVVLLATLALSPEEFKQRVSKDKAPRPVLDANATAILISALQKRQAQYATSLASDLQFRASLSPLSETGDVDEAARRVRMALQVRIGEKEVLQTVLGMLQPATSGSLKRSANGDGGDSRQFKTQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6R4</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
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                <person name="Conseiller E."/>
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                <person name="Sallet E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48187">
        <property type="entry name" value="LD21810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48187:SF2">
        <property type="entry name" value="LD21810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="1">
        <location>
            <begin position="354"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL22016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="723" mass="81656" checksum="F2B25784C9E6B10B" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6U3</accession>
    <name>A0A0G4P6U3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
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    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S006g000489</name>
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    <organism evidence="1 2">
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        <lineage>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL21949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="137" mass="15595" checksum="B13407AC9F6BCD79" modified="2015-09-16" version="1">MSAQQQSLSQWVTQINDTLFIQPNDEIALKAVDDQVDPSLVVSHIARINHNVYNYDQFKAGLQYARGSSISIQDEFSVILKWENLEKPEGVVAVRSKWTTKDKTTGKETKKTNVILWEVKWIGGKRKLTGQTEVESM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="8">Fungal transcriptional regulatory protein, N-terminal</fullName>
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        <name evidence="8" type="ORF">PCAMFM013_S006g000554</name>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
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    </dbReference>
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        <property type="entry name" value="AAA_Catabolism_Regulators"/>
    </dbReference>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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            <end position="48"/>
        </location>
    </feature>
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        <location>
            <begin position="57"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL22014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="681" mass="76333" checksum="3BD1AA8DA0F78587" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7K3</accession>
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        <submittedName>
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    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
            <strain evidence="3">FM013</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL21865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL22249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL27047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="99" mass="11485" checksum="B92A0E9CF39FDA49" modified="2015-09-16" version="1">MEAASILSAMKGEKLKDSPQWLTWFAKVQLYAMQKNVWDLCNPDLIPASTTTTDSSTKRPTPLTEPVEPDYPETGDDTAKRTWRDRMDVYKIRYAKWEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7X2</accession>
    <name>A0A0G4P7X2_PENC3</name>
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        <submittedName>
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        </submittedName>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL22405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="160" mass="17853" checksum="2523A1B404C90668" modified="2015-09-16" version="1">MNSTSNTTENITNTMVNVTLTEPQRHKVYIVKYNFDSSPPEGDSAIFVKTNEDVGHIHFIASNGAGSHLYYDRATIMAHEAKETGESLMLIGTTLTENYPGSWDEALRVVEENQQYTTTSLALSGSAQAEMRRSKVSRWTQECARPTLEKAGLLEKIIEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P825</accession>
    <name>A0A0G4P825_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein N-terminal and lysine N-methyltransferase EFM7</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongation factor methyltransferase 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EFM7</name>
        <name evidence="7" type="ORF">PCAMFM013_S007g000395</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono- and dimethylation of 'Lys-3'.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF10">
        <property type="entry name" value="PROTEIN N-TERMINAL AND LYSINE N-METHYLTRANSFERASE EFM7"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
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        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
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        <location>
            <begin position="80"/>
            <end position="82"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
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        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="140"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
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        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL22414.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="270" mass="30211" checksum="B67B5DD914883126" modified="2015-09-16" version="1">MADEFDSGNLFQDPEGYYPEDAPPTFAEHSMLSGQKVRVRLVGSHPLYGNLLWNAGRTSSHYIEEHTEDLIRNKDVLEIGAAAGVPSIVSAIQGARTVVLTDYPDPDLVENMKYNAELSASAIPAREDGKPRLHVDGYKWGSDVTPLRAYLPPAADGSPSLFDVLIMADVVYSHREHPNLIKTMQQTMKKDPKSVALVIFTPYQPWLLPKTEQFFPLAEASGFTVTKIFEKVVDAVLFEKDPGDERLRRTVFGYEIRWAQDQLEDSSKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P8A0</accession>
    <name>A0A0G4P8A0_PENC3</name>
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        <submittedName>
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        </submittedName>
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        <name evidence="3" type="ORF">PCAMFM013_S007g000539</name>
    </gene>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793140">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="72"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL22558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="284" mass="31248" checksum="FA543B29589C9A39" modified="2015-09-16" version="1">MAATSKPTLTITHVTTATAILNIDGVNFLTDPFFGAIEGTEYDSTAVWEQVDLRQFGFESIPPPPHLINKQGPALQLNELPPIDAVLLSHEDHLDNLDPEGRKLLDGRKVFTTVDGATNLRPRPGVVGLRPWETVTSCIGGKLYRITGTPCKHFPIGEVTGFVLETDSFGLDSSGKPNAIYFSGDTVYIDELREIGKRWHITAAIFNLGNATFDFPTGPVQITMDGKQAVQLARDIGADVMVPIHFESWEHFKEGRAELEEVFTQEGFLDKVCWTAPGIPKVVF</sequence>
</entry>
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    <accession>A0A0G4P8B6</accession>
    <name>A0A0G4P8B6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L26, eukaryotic/archaeal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S007g000490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793140">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="60S ribosomal protein L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_A">
        <property type="entry name" value="Ribosomal_uL24_A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_uL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005756">
        <property type="entry name" value="Ribosomal_uL24_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01080">
        <property type="entry name" value="rplX_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11143">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L26 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16906">
        <property type="entry name" value="Ribosomal_L26"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL22509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="134" mass="15067" checksum="6C85C34BA2ABAC04" modified="2015-09-16" version="1">MAVRTHGIASSRSKSRKAHFQAPSSERRVILSAPVSKELKEKYGIRSIPIRKDDEVVVARGSQKGREGKITNVYRLKFSIFVEKIVRDKSNGQSVPIPLHPSKVVITKLHLDKDREQIIERIAKGREAVKSKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P936</accession>
    <name>A0A0G4P936_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dual specificity phosphatase, catalytic domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S008g000238</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P936"/>
    <dbReference type="STRING" id="1429867.A0A0G4P936"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140096">
        <property type="term" value="F:catalytic activity, acting on a protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990444">
        <property type="term" value="F:F-box domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062026">
        <property type="term" value="P:negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070372">
        <property type="term" value="P:regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052449">
        <property type="entry name" value="STYX-Interacting_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588">
        <property type="entry name" value="SERINE/THREONINE/TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588:SF1">
        <property type="entry name" value="SERINE_THREONINE_TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="172"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="287"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="307"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL22809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="339" mass="37999" checksum="091282185DA3D604" modified="2015-09-16" version="1">MFNGNSQREVPMSHNEQSHYVRAQEYTATPRYPPSTGSLGAGHFGFSGNDDTVIVDPKNFNRDSHHFAEGDFICPGFFNHVDLGGFTRRFNPSQWNYDMRRQAQSILPFLSLGPSSCLRDAEYIRSQGFTLLLAIRSRHSALARLVSGEKAATEAGIMADTVDVLDNQELISAFPRAIRRINDHLAGVDVGPDGMVSDGQQQKKKVLVFCESGNERSAAVIIAYIMVMLNIQSVEATHMIQQRRFCVSIEDTMKYILTAFETILSAKRDVERAKKFTVRGAASLAPPSAPPMLAKKRSFQDHRNDDLVMEEGEMDVDEDDNEDPFYTRKPNAPFQDRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P986</accession>
    <name>A0A0G4P986_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Surfeit locus 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S008g000312</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P986"/>
    <dbReference type="STRING" id="1429867.A0A0G4P986"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002995">
        <property type="entry name" value="Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427:SF1">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02077">
        <property type="entry name" value="SURF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL22883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="303" mass="33964" checksum="2923E1E64E8B1942" modified="2015-09-16" version="1">MAQIRGTAGYNLGHQNPFGGPGSADATSDPSPLDAIREQTSKIEDWLDTLADPVKPYLPAVGRFLIVVTFIEDSLRILTQWNDQLLYLRDFRKIPWGITHTFLIVNVIAMAVCSTLVIARKRTEFAVAGLLGVVITQGLGYGLIFDLNFFLRNLSVVGGLLMVLSDSWVRKKFVPAGLPQLDEKDRKMYVQFAGRVLLIFLFVGFVFSGEWSFWRILVSLFGLVACVMVIVGFKAKWSAIILVVLLSLFNVFVNNFWTLHAHHPQKDFAKYDFFQILSIVGGLVLLVNMGPGQLSMDEKKKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P9S4</accession>
    <name>A0A0G4P9S4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S008g000458</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL23029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P9S4"/>
    <dbReference type="STRING" id="1429867.A0A0G4P9S4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052478">
        <property type="entry name" value="Metabolite_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31779">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31779:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="517"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="517"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL23029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="559" mass="63341" checksum="A87042F157F10C2A" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PA02</accession>
    <name>A0A0G4PA02_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S009g000044</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PA02"/>
    <dbReference type="STRING" id="1429867.A0A0G4PA02"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000001">
        <property type="entry name" value="50S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_uL6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_uL6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL6M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="5">
        <location>
            <begin position="85"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="5">
        <location>
            <begin position="153"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL23104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="251" mass="27477" checksum="57ECE425302F91E1" modified="2015-09-16" version="1">MSCSIPQRCARQLLREPFQRGSLPIFLAPAFSPRTQCFSTTSPAQSRVGGAALSIPPEVSFKLIDIPATLSRTRGKDIPKFMAEIKGPKGEMSLNIPSFLTITPDETGQKTSLSVLDQTVPHQRAMWGTIRSLLQNHILGVSEGHVCVLSMVGVGYRATIEDKASTVQADYPGQKFVSLKVGFSHPIELGIPQGVVASTPQPTRILLEGVDKRVVTQFAAEIREWRRPEPYKGKGIFVNGETIKLKAKKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PA71</accession>
    <name>A0A0G4PA71_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S009g000156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PA71"/>
    <dbReference type="STRING" id="1429867.A0A0G4PA71"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL23216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="529" mass="60846" checksum="65A2F8B526EB8A5A" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PA94</accession>
    <name>A0A0G4PA94_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Crotonase, core</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S009g000178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PA94"/>
    <dbReference type="STRING" id="1429867.A0A0G4PA94"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006108">
        <property type="entry name" value="PRK08259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43802">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43802:SF1">
        <property type="entry name" value="IP11341P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL23238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="273" mass="28998" checksum="E7E57F5FAFB1E63E" modified="2015-09-16" version="1">MAEHNRVTTDTSSYPGISVVAINRPDRKNAVDPLTAKALYEAILVFEDDPKQKVCVLTGAGSSFCAGADLHSVAQANNDTPGDNLQPINGRNLGPMGPSRLIIKKPVICAISGYAVAGGLELSLLTDMRVVEEDAVFGVFCRRWGVPLIDGGTVRLQAIVGIGRALDMILTGRPVSAHEALTMGLASRVVPKGESLKEAIGIARQLTTFPELCLNTDRQSCYYSAYEASSFQDAMSQEFNAGSKVISQEAIAGAAKFSKGSGRHGSFKDHSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAJ1</accession>
    <name>A0A0G4PAJ1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S009g000268</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PAJ1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PAJ1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DBAG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL23328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="498" mass="55161" checksum="7B89F28BB086EE6F" modified="2015-09-16" version="1">MPARGRASRNCGNCRSIKRRCDQKFPHCGQCIRAREECQGYRDEWELVFHDQTTHTIKRSKEAWAKADGLETMKRSPPSRTLGLSSDEVGVNYFLFHFVVGGLSPSRGYLNYVPAVFSADGESPTLMASMAAVGLAALANSTQQPELFQRAHTKYWEAIDKVNAALSSSVESIKDSTLMSVISLGLFEHVSNFETWFQYVKGTVALVVSRGKSQFSSPASIPMFNQVRADMCAACVHRLEPFPRDMLELQEEANKQADNSSCFWLLGVLATRTVNLLSDVTVVTIKDGATLAHFVQESAVLQRDFQDVLGNFRTQEPYTTIEDYSGDPDLVYNSRYDLYRSAWAIRLWNNSRILQVIVCEIEFHLLSKALTANPPPAHRKQIATTLEATCQILKTLGDDILATVPQSLGAVLPPTEPPTSADLSSDPSANASASGGHLLLWCLYTVGKSPVTRGRARKWVMKRLRDISQKSGLPIALQFVNDIDEIDKAASMLESADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAR2</accession>
    <name>A0A0G4PAR2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S009g000347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PAR2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL23407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="50" mass="5428" checksum="F0D3EB0508B88C65" modified="2015-09-16" version="1">MLSTANLAGGGDALMLFRPSSMYYAGELETNSHSVGFSLFLLWLFVILSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAS1</accession>
    <name>A0A0G4PAS1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S009g000351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PAS1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL23411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="252" mass="29262" checksum="F198AD06EEF8FCE8" modified="2015-09-16" version="1">MAVPRSWFPSGLNEGDTVTLTKPKTSKWILDKMINTHDDQCRNRSLDSYVSILFECHNPTNGQEAFMRVYVQVPHTGYEGADKATRAREAIEFTPPELKAYKSLTDKGSQNTPPLLAYELGTQGSSDIVPNGHITWIVWKKVPGKRLGDFRSAFVYWNMDRDERDRIREAFLREFPKAKRSGYFPEGAKPRNLIWDENNGDLYFVGFRDAMPFKAKGEFNEAWLPRFDLARPPQKHFRRYIDYNGDISDWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBU4</accession>
    <name>A0A0G4PBU4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidine phosphatase superfamily, clade-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S010g000193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PBU4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF54">
        <property type="entry name" value="PHOSPHATASE SPAC5H10.03-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL23755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="218" mass="24337" checksum="2CE0E56BA5C8B613" modified="2015-09-16" version="1">MSFRLHLIRHAEGTHNPGHDTTILDPPLTEKGIQQCLKLSQDFPFKESVGLVMTSPLRRTLQTARLGFQQSIDEKYYAQGSGAGVQNGARLVLEPDVQAHSARPCDTGSDIAILRSEFYDLPWEILDLDPTFPAKEGLYASDPESLKLRGARIQGRLEQKFKELKDSGRPDIVVVTHGGFLSYVIGQEKTEVGQARWKTFIVTFDQDSRIVVESVLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCY7</accession>
    <name>A0A0G4PCY7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S011g000179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PCY7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="645"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="826"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="650"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="840"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL24185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="849" mass="95392" checksum="F119B31923F75C05" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDE8</accession>
    <name>A0A0G4PDE8_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutamate--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S011g000339</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PDE8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PDE8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000045">
        <property type="entry name" value="Glutamate--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049940">
        <property type="entry name" value="GluQ/Sye"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311:SF2">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="An anticodon-binding domain of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="13">
        <location>
            <begin position="40"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class I anticodon-binding" evidence="14">
        <location>
            <begin position="517"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="565"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CRL24345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="590" mass="65664" checksum="46D37250C998CB35" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PE01</accession>
    <name>A0A0G4PE01_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S012g000135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PE01"/>
    <dbReference type="STRING" id="1429867.A0A0G4PE01"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL24526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="175" mass="19265" checksum="502C1D84AAE69BB3" modified="2015-09-16" version="1">MEEQGHIPLSLKEIMALQHSKGLTEYEAWRQAVIYYNQQRGGHADATNLARTSDEIPLGESVLTSKTAPASGTHTTHLNHPPVNAAGENHILIACKPDDPMAQERVRENTERLIDSGVATKLCTDCALDASLFDRTKTPGALQDNAETDEKRAQEAHLRYWAAIGGRDNEIGKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PE93</accession>
    <name>A0A0G4PE93_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc finger, C2H2-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S012g000191</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ARS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PE93"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025239">
        <property type="entry name" value="DUF4187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039727">
        <property type="entry name" value="SE/Ars2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007042">
        <property type="entry name" value="SERRATE/Ars2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021933">
        <property type="entry name" value="SERRATE/Ars2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13165">
        <property type="entry name" value="ARSENITE-RESISTANCE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13165:SF0">
        <property type="entry name" value="SERRATE RNA EFFECTOR MOLECULE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04959">
        <property type="entry name" value="ARS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13821">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12066">
        <property type="entry name" value="SERRATE_Ars2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01173">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="670"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="465"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="551"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="780"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="488"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="791"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="842"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL24581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="894" mass="99881" checksum="63E7527AB93CAB99" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PED1</accession>
    <name>A0A0G4PED1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S012g000302</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793145">
        <property type="protein sequence ID" value="CRL24692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PED1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PED1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF156">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="44"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL24692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="485" mass="53602" checksum="3ECB88D84CEFF1CF" modified="2015-09-16" version="1">MGSDCIEVEVEKEEPQGCDLLIDFDHPNDPRIPQNWPLAKKVLVVVILSVFNLIGTITSSIMSPAHTTVAEQFGASREVAILCTTLFMAGYIFGFLTFGPLSEKFGRKWPLIGGVAICSFLELMPALGTNIQTIVIGRLFAGFFGVSPVAVMGGITSDCFTLAHRSIAMPIVICLFFSGPTFGPIVGSAIVGSSLSWRWTIWVMLISGLGVCAIAAFIFPETYPPAILRKEARVLRKKYKNRAIRSALEKEQSGVHDFVRLYLLRPFWLFSTQPILALLTLYQSFLYGVLFLFYQAYPYYFGEIRGWNTSVDTLPLLGIITGVFIGTLGIIIYNQVYFRHHCYTSDGTFIPESRLPPMIFGGVLIPIGIFWFAWTAQPNIPWPSPLCAGLLMGCGMYLVFIQGFIYIVDCYTTMANSAMGINGSMRSIFGAAFPLFATQMFEKLGVPHSTTILAAVTVCLIPVPVCFWYWGDRIRARSSAKVSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PEZ1</accession>
    <name>A0A0G4PEZ1_PENC3</name>
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        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PCAMFM013_S013g000088</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 20">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="15"/>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL24845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4PEZ1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02584">
        <property type="entry name" value="RNAP_II_Rpb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02733">
        <property type="entry name" value="RNAP_II_RPB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
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    </dbReference>
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        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
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    </dbReference>
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        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
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    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.140">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000684">
        <property type="entry name" value="RNA_pol_II_repeat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007075">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007073">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038593">
        <property type="entry name" value="RNA_pol_Rpb1_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF37">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04992">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04990">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05001">
        <property type="entry name" value="RNA_pol_Rpb1_R"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00115">
        <property type="entry name" value="RNA_POL_II_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 15" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="17">
        <location>
            <begin position="241"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1502"/>
            <end position="1738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1506"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1561"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1597"/>
            <end position="1673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1681"/>
            <end position="1738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CRL24845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1738" mass="191851" checksum="1DF98FDB2F207112" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PF08</accession>
    <name>A0A0G4PF08_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase superfamily, zinc-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S013g000103</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
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        <property type="protein sequence ID" value="CRL24860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
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        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
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        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="15"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL24860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="349" mass="37669" checksum="67121D45A74AEAA5" modified="2015-09-16" version="1">MASSNTSLIVRVPEGQPKLVKEELPLPKPGTDQVQVKVSHVAQNPTDVQCFDVNAFGDGAVLGCDFVGEVTELGGAVTRLDKGDTVAGLIWGGEIPGLGGYSQYTIADQRISFKVPASISREEASTVPLAAATAWLALFSKDCLNIDRSKVQGTSVLVWGGSSSVGLYAIQLAVIYGLDVITTCSPHNTDLVRSYGAKHVFDYNDPKVIEKITEAAPDLQYAFDTIGNTASSALSSQAFGDRDGRLCTVRPGKANTEYVAANTHVTDVLVWTAFLKDHGYGEFHWPASKDDHELASELFENLPSWFEQGQIKPNKARVLLGLDSVPEGFQEYRDGKISAYKIVYEVVHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PFU2</accession>
    <name>A0A0G4PFU2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIM-barrel signal transduction protein, predicted</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S014g000084</name>
    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PFU2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PFU2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.460">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009215">
        <property type="entry name" value="TIM-br_IGPS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051353">
        <property type="entry name" value="Tobamovirus_resist_UPF0261"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31862">
        <property type="entry name" value="UPF0261 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G10120)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31862:SF1">
        <property type="entry name" value="UPF0261 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G10120)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09370">
        <property type="entry name" value="PEP_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF034452">
        <property type="entry name" value="TIM-br_sig_trnsd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIM-barrel" evidence="1">
        <location>
            <begin position="9"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL25188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="279" mass="29637" checksum="896907EB07E9FC62" modified="2015-09-16" version="1">MAPPTSRSEILANLRRQIEAGKPIVGAGAGIGLSAKSVEAGGADLVIIYNSGRFRMAGCGSLAGLMPYSNANEVVVEMAAEVIPIVQNIPVIAGVCGTDPFKHIPRFLKQLRDLGFGGVQNFPTVGLIDGNFRANLEETGMGYGKEVEMVRQAAELDMLTTPYVFNVEEAEAMTKAGADILVAHMGLTTSGLIGAKTGKTLEKCVEEIQAIRDAAVRINKDIIVLCHGGPIAAPEDAKFVLDRVQGVHGFYGASSMERLPVEVAIKDTTAEFKKIVLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PG34</accession>
    <name>A0A0G4PG34_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S014g000158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PG34"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL25262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="76" mass="8504" checksum="16C6218FD67D57BB" modified="2015-09-16" version="1">MSSLLGQVGLKMDSRAQRSYLDGLHSSWAMWITLFGMTFLCALIPKRGKVPRLGEDGGKDATFFLRHSRFELGLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PG47</accession>
    <name>A0A0G4PG47_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Trimeric LpxA-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S014g000131</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PG47"/>
    <dbReference type="STRING" id="1429867.A0A0G4PG47"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03357">
        <property type="entry name" value="LbH_MAT_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051159">
        <property type="entry name" value="Hexapeptide_acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416:SF54">
        <property type="entry name" value="ACETYLTRANSFERASE, CYSE_LACA_LPXA_NODL FAMILY (AFU_ORTHOLOGUE AFUA_2G08430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416">
        <property type="entry name" value="SIALIC ACID SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Maltose/galactoside acetyltransferase" evidence="3">
        <location>
            <begin position="12"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL25235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="216" mass="23632" checksum="3CDBAD8838F44D27" modified="2015-09-16" version="1">MTVPAMSEPTEKEKMLRGELYRAFTPDLIAARSRCKWACNRFNKSDEVPRRRLVEMWRDIADDKTPLPPKLDDPAADEALFEQDPWVESPVHIDYGFNVKLGAGVFVNFNCVFIDTCPITVGARTLFGPNVSLFSGTHPLDPALRNGTEGPETGKPIVIGEDCWLGGNVTVLPGVTIGRGVTIGAGSVVTKDVPAFHVAAGNPARIIRRIETTMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PG69</accession>
    <name>A0A0G4PG69_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Carboxyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PCAMFM013_S014g000193</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP = N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hydrogencarbonate + acetyl-CoA + ATP = malonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11308"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4PG69"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.460.10:FF:000001">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000005">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000005">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000005">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000010">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.460.10">
        <property type="entry name" value="Biotin dependent carboxylase carboxyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1770.10">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049076">
        <property type="entry name" value="ACCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049074">
        <property type="entry name" value="ACCA_BT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013537">
        <property type="entry name" value="AcCoA_COase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728:SF3">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08326">
        <property type="entry name" value="ACC_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21385">
        <property type="entry name" value="ACCA_BT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0092">Biotin</keyword>
    <keyword evidence="9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="21" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="18">
        <location>
            <begin position="46"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="17">
        <location>
            <begin position="198"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="16">
        <location>
            <begin position="681"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="19">
        <location>
            <begin position="1506"/>
            <end position="1848"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="20">
        <location>
            <begin position="1852"/>
            <end position="2167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="427"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CRL25297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="2273" mass="253484" checksum="577C20FDA97F5A56" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PHC2</accession>
    <name>A0A0G4PHC2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S015g000238</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793148">
        <property type="protein sequence ID" value="CRL25652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PHC2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PHC2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000020">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000006">
        <property type="entry name" value="60S ribosomal protein L8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="5">
        <location>
            <begin position="11"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="4">
        <location>
            <begin position="96"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL25652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="254" mass="27343" checksum="035F60CC7536F537" modified="2015-09-16" version="1">MGRVIRNQRKGRGSIFTANTRLNKAPAQFRTLDFAEAHGYTRGVVKEIIHDAGRGAPLAKVQFRHPYKFKMITETFIANEGMYTGQFIYAGKNAALTVGNVLPLASMPEGTVVTNVEEKAGDRGALGRTSGNYVTVIGHNPEDGKTRVKLPSGAKKVIKNTARGMVGIVAGGGRTDKPLLKAGRAKHKFAVKRNSWPKTRGVAMNPVDHPHGGGNHQHIGKASTISRYATQGQKAGLIAARRTGLLRGTQKTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PHH9</accession>
    <name>A0A0G4PHH9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S015g000261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793148">
        <property type="protein sequence ID" value="CRL25675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PHH9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL25675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="56" mass="6300" checksum="1B5E1B0FCACD8D92" modified="2015-09-16" version="1">MIPTCRSISFSIFPSLMGAAVEKPEIAAHKFRRSLPHRQGTVLRVHALAWTCQNTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PI37</accession>
    <name>A0A0G4PI37_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S016g000132</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="HG793149">
        <property type="protein sequence ID" value="CRL25851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PI37"/>
    <dbReference type="STRING" id="1429867.A0A0G4PI37"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033096">
        <property type="entry name" value="PPPtase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="8">
        <location>
            <begin position="108"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="189"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR033096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL25851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="428" mass="46597" checksum="09F815D0C8A88C7A" modified="2015-09-16" version="1">MSDLDRAIEQLRACRLIPESQVRELCYKARELLIEEGNVVSVDAPVTICGDIHGQFHDLMELFRVGGDVPDTNYLFMGDFVDRGFYSLESFLLLLCLKVRYPDRITLIRGNHESRQITTVYGFYDECIRKYGSANVWRYCCEVFDYLALGAIVLGASSELEPSSNTALSSMPIDDSELETEVLNSRGEVTMSTYRARQRSSSDVSTDSRNISPPRDISAAPGQAAAPSRSGAPGTGASGDGNGSAATSRTGAVLCVHGGLSPLIDSVDKIRLIDRKQEVPHEGAMCDLLWSDPDEIEGWGLSPRGAGFLFGGDIVKQFNHLNGLSLVARAHQLVMEGYKEMFDGGIVTVWSAPNYCYRCGNVAAILELGEDASGGGTVARSNGEYGRSNGIVTDNRVVSPGRRYRVFEAAAQDTRGMPAKKPVADYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJL7</accession>
    <name>A0A0G4PJL7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S018g000049</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJL7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJL7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF8">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL26356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="309" mass="34191" checksum="464FF4451D27D861" modified="2015-09-16" version="1">MLITRDGAPIECTKVTPECPVEGTIYGYAPNFAASIAFCAIFGILGLIQLVQVLKWRMWSFGIPVVLGAVSEVIGYVGRLMLHSNPYSDVGFQTQICTLIIAPAFWSAAIYLTLKHVVNLFGRKYSMLRAAWYPYIFVPCDILSLVLQGAGGALAATATTPDDSSLGSDIMLAGIVWQVVTLTVFGLLWAQYFWRIKKAHGHYLSVEAENVWVRKNFWVFCGGIVVAFLTTYARCVYRIAEMAGGWQNSIMQDELTFIIFESAMCAVAVLALSITHPGHFFKHMNGKYESVNTEDSISLQAKLDRESVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJS8</accession>
    <name>A0A0G4PJS8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S018g000096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJS8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL26403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="83" mass="9900" checksum="5F14E1E0B812417F" modified="2015-09-16" version="1">MSTPRTRPYPRIRSPDRWINDVMTLTVCAQLQIRYACGHSTGGEFIKCQRHMRKEDERCISRQIRHIDIKQSTHKCRLCLRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PK18</accession>
    <name>A0A0G4PK18_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein S7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S019g000184</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PK18"/>
    <dbReference type="STRING" id="1429867.A0A0G4PK18"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.455.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_uS7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_uS7_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003106">
        <property type="entry name" value="PRK04027.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="5">
        <location>
            <begin position="59"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL26767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="211" mass="23469" checksum="6422BE2DABD20674" modified="2015-09-16" version="1">MSDNGDVEVAAFPVLPKEVLAEQGSIKLFNKWSYDDVEIRDISLTDYIQIRSPVYLSHSAGRYAAKRFRKAQCPIIERLTNSLMMNGRNNGKKLLAVRIVAHAFEIVHIMTDQNPLQVAVDAIVNCGPREDSTRIGSQGTVRRQAVDVSPLRRVNQSISLLTIGAREASFRNIKSIAECLAEELINAAKGSSNSYAIKKKDELERVAKSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PK38</accession>
    <name>A0A0G4PK38_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rieske [2Fe-2S] iron-sulphur domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S018g000216</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PK38"/>
    <dbReference type="STRING" id="1429867.A0A0G4PK38"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00657">
        <property type="entry name" value="Ferritin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03467">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="DUF455"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42782:SF2">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42782">
        <property type="entry name" value="SI:CH73-314G15.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04305">
        <property type="entry name" value="DUF455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ISP domain"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="6">
        <location>
            <begin position="49"/>
            <end position="114"/>
        </location>
    </feature>
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        <location>
            <begin position="218"/>
            <end position="249"/>
        </location>
    </feature>
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        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL26523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="462" mass="50671" checksum="1CFC3B2B1414F03A" modified="2015-09-16" version="1">MWINCGKLSDFTQARYVVRLTTDKKVVLFRLPTIDKSSLKSNETNDGWSYYAMEAECPHAGGPMADSSVDIEDSAYVVSCPWHAYDFNVETGESSVGIKACTFPVDVRGEFVALDFPAEDGVSVGLASVDPVSEKVKLKHPRSAEKVAAITTAIASVSISESASTGREDPGMATYLADDATLCDWAAHVLNTANPEHKIELTTHLFSIFTAGEASDSPMPLGRGTVAPPDQPPREKMETVDPGHMPKAGRGGTLKSRIAMLHALANIELWAIDLAIDICIRFATFQTEGTSQELPRAFFYDWLKVANDEAKHFSLLRTRLEEMGSSFGSLPVHHSLWLSATETAYDLRARISIIALVHEARGLDVNPMTIEKFRKAGDGESVATLEIIHNDEITHVTTGHRWLTWICAQEGTDPVQVFRSNVQRHFKGPIRGPFNEEARLQAGMDKRYYENSCVPSAGIAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PK81</accession>
    <name>A0A0G4PK81_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphatidate phosphatase APP1 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S018g000267</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PK81"/>
    <dbReference type="STRING" id="1429867.A0A0G4PK81"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019236">
        <property type="entry name" value="APP1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052935">
        <property type="entry name" value="Mg2+_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208:SF2">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1 CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09949">
        <property type="entry name" value="APP1_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195752" description="Phosphatidate phosphatase APP1 catalytic domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidate phosphatase APP1 catalytic" evidence="3">
        <location>
            <begin position="277"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL26573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="531" mass="57347" checksum="96B94DB52F411A4D" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKP4</accession>
    <name>A0A0G4PKP4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small ribosomal subunit protein mS37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S020g000073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the mitochondrion-specific ribosomal protein mS37 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793153">
        <property type="protein sequence ID" value="CRL26914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKP4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PKP4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017264">
        <property type="entry name" value="Ribosomal_mS37_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28066">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28066:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037706">
        <property type="entry name" value="MRP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL26914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="102" mass="11414" checksum="C1A9A85DE857E6C8" modified="2015-09-16" version="1">MAPKGSISTRLNPMRLNTINHLRVRRPNQNEQNPCVVVMSSMLNCWASAGYGAEGCAALEAQLRKCMDAPKSREQKKNTVNYHLMRMYPKVVGPRKKDGVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKX8</accession>
    <name>A0A0G4PKX8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S020g000173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793153">
        <property type="protein sequence ID" value="CRL27014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKX8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PKX8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054505">
        <property type="entry name" value="Myb_DNA-bind_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22980">
        <property type="entry name" value="Myb_DNA-bind_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like DNA-binding" evidence="2">
        <location>
            <begin position="37"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL27014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="130" mass="14458" checksum="B259EC446913911D" modified="2015-09-16" version="1">MAPKRVTKAKATKKKDVGKSATKPGKLASEASREILEERLEFVITCLKETGIKVDMAAVARHYGISNNAAKLRLRRANDCVAKMVGAREEARKGDEPQSDDEPQEDDEPQEDDEPQEDDEDLETTEDEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PLF9</accession>
    <name>A0A0G4PLF9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S020g000142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793153">
        <property type="protein sequence ID" value="CRL26983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PLF9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL26983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="116" mass="11132" checksum="4CCCE54C3DEB3723" modified="2015-09-16" version="1">MGLFSHHHDKHDENKHHEGGHQQGHQQGPGGPQGGPQGGFQGHQQGGPQHGGPQGGFQGQQQGGPGGFGGPQGGFQGQQQGGPGGFGGPGGQQGGHGGHGGHGGGHGGPQGGHGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PLP5</accession>
    <name>A0A0G4PLP5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Proteasome, subunit alpha/beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S021g000016</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793154">
        <property type="protein sequence ID" value="CRL27101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PLP5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PLP5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03757">
        <property type="entry name" value="proteasome_beta_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000027">
        <property type="entry name" value="Proteasome subunit beta type-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL27101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="259" mass="27959" checksum="C14D0F741563FCF0" modified="2015-09-16" version="1">MTSLMGNQSGTIGYSFSEPTSANVKQHSFYPYTDNGGSTLGITGADFAILAGDTRSTSGYNINSRMVPKVFKIGGDDETGEGATIILSVVGFAADGNALKEKLDTVVKMYKYQHGKSMSVSACAQRLSTILYEKRFFPYYVHAILAGLDEEGVGALYSYDPVGSYEREQCRAAGAASSLIMPFLDNQVNSKNQYIPGSGEGHALVPKKAEPLDKETAKKLVQDAFTSAVERHIEVGDGLQMVIVTREGIEEVFHALKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PLX8</accession>
    <name>A0A0G4PLX8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S022g000097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793155">
        <property type="protein sequence ID" value="CRL27417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PLX8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL27417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="114" mass="12956" checksum="D9C4D3FC7E17C85C" modified="2015-09-16" version="1">MCTHLHQTQDRGDWERPKPTVQISDHQLESCKALCGLYIFYHRGMTARYMTGWWTLGTRIGDTQVGYVRVRDPSYVLFIAIAMLGTSLTGLEYGVPGANIQTEDLSRRAYTTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PME2</accession>
    <name>A0A0G4PME2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cystathionine beta-synthase, core</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S023g000060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793156">
        <property type="protein sequence ID" value="CRL27602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PME2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PME2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04618">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04641">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF35">
        <property type="entry name" value="LD22662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="93"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="175"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="249"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="320"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL27602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="382" mass="42862" checksum="CAD6E2E20458FD91" modified="2015-09-16" version="1">MAPKTCRRVYIHVVYIVEQGSFECSRSLSPTYRKAEDPRLGTSISGHAPFVQPILVPTPPMASERAIDREERQGLRAIRDFLKARNSYDVLPLSFRLIIFDTSLSVKESLNILIQNGIVSAPLWDSKASKFAGLLTTSDYINVIQYYFQNPAALDQIDQFRLDSLREVEKALGVAPPETVSIDPERPLYDACRRMLESRARRIPLVTSDSQTERPHVLSVITQYRILKFVAVNVPDTQQLRRPLGELLLGSYDNVATASMDTPVIDVIHILVERSISSVPIVNSEGVVYNVFESVDVITLIKGGFYDDLSLTVGEALKKRSPGFPGIYTCSLNDGLDTIFDTIRKSRVHRLVVVDEHFKLKGVLTLSDILHYILLEGENEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PN71</accession>
    <name>A0A0G4PN71_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S023g000084</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793156">
        <property type="protein sequence ID" value="CRL27626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PN71"/>
    <dbReference type="STRING" id="1429867.A0A0G4PN71"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050889">
        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF48">
        <property type="entry name" value="PROTEIN VAPYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="51"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="284"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL27626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="361" mass="38570" checksum="287ECC23BCDF2C6A" modified="2015-09-16" version="1">MTLSLLPAELLISIANHLLSSPQALNCLAQTSRLLYQITNPILYKNQIVHNESSALLWAAERGKPAPCRRLLSEGANPNIKDSHKRTPLSWAAGNGHADIVSILLSTAQTDPNARDAYFQIPLFWAAGNGLRSCTHIPWGHPPSYARELATADYLGIVKLLLSTINIQPDLRNLRGETPLSVAAGEGEESIVEELLRTGNVDPNSKDRFGQVPLMAAAENGHLGVVKRLIGIEGLEADARSHEGFSAFTVAACYGHAEIVKLLLTVPTVDPNQKKEVDPNMASDGVTALMVAANQGRNGIMQSLIAGGAEPDVKDSGGKTPLMIAVHEGNVEAVEILLSTGRVAADFDLAMRGVAFFLSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNH6</accession>
    <name>A0A0G4PNH6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S023g000186</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793156">
        <property type="protein sequence ID" value="CRL27728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PNH6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PNH6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="7"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="50"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL27728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="688" mass="77507" checksum="9B44022280898D46" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPD5</accession>
    <name>A0A0G4PPD5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Alpha-galactosidase</fullName>
            <ecNumber evidence="6 12">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PCAMFM013_S026g000115</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 36 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="6 12"/>
    <dbReference type="EMBL" id="HG793159">
        <property type="protein sequence ID" value="CRL28250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PPD5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PPD5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14791">
        <property type="entry name" value="GH36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000028">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000118">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.60">
        <property type="entry name" value="alpha-galactosidase from lactobacil brevis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038417">
        <property type="entry name" value="Alpga-gal_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050985">
        <property type="entry name" value="Alpha-glycosidase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002252">
        <property type="entry name" value="Glyco_hydro_36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031705">
        <property type="entry name" value="Glyco_hydro_36_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031704">
        <property type="entry name" value="Glyco_hydro_36_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053:SF3">
        <property type="entry name" value="ALPHA-GALACTOSIDASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053">
        <property type="entry name" value="GLYCOSIDASE FAMILY 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16874">
        <property type="entry name" value="Glyco_hydro_36C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16875">
        <property type="entry name" value="Glyco_hydro_36N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02065">
        <property type="entry name" value="Melibiase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005536">
        <property type="entry name" value="Agal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00743">
        <property type="entry name" value="GLHYDRLASE36"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 12 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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                <person name="Debuchy R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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            <fullName evidence="10">Potassium transport protein</fullName>
        </recommendedName>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="Cat_transpt"/>
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    <dbReference type="PANTHER" id="PTHR31064:SF30">
        <property type="entry name" value="HIGH-AFFINITY POTASSIUM TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR31064">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TrkH"/>
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        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
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            <end position="46"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="706"/>
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            <end position="319"/>
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        <location>
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            <begin position="162"/>
            <end position="171"/>
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    </feature>
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        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
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            <end position="203"/>
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    </feature>
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        <location>
            <begin position="220"/>
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    </feature>
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        <location>
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        <location>
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        <source>
            <dbReference type="ARBA" id="ARBA00009137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR002450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL28031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="825" mass="92709" checksum="549EB9BA977CB9F8" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPQ8</accession>
    <name>A0A0G4PPQ8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-hydroxy acid dehydrogenase, FMN-dependent</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S027g000039</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793160">
        <property type="protein sequence ID" value="CRL28350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PPQ8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PPQ8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF82">
        <property type="entry name" value="CYTOCHROME B2, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G07200)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="7">
        <location>
            <begin position="23"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="102"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="316"/>
            <end position="320"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="339"/>
            <end position="340"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL28350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="423" mass="45760" checksum="2E0346CC9C17F775" modified="2015-09-16" version="1">MTRISNADEHPTRANKSQNEEALSMESLKSLDEFESLATKQISKKAWSFNYAGAGDLISKRLDQEVYRSILLRPRVLVNVKECDLSTTIIGERVGLPIFVSPMAMARLAHPTGEAGISAACGVFGAMHIISNNASMTPEEIVVGAAPEQVFGFQLYVQTDRTESEAVLARINKLPAIKCIVLTVDEPVQGKHELGPRGFELYDDAQTEVPTQPEESSQPSTDVKVAIPSVSGPASDAEWEITLQWLAKHTSLPIIIKGIQTYEDAEVAATYAHVKGIVLSNHGGRVLDTAPPAIHTLLEIRKYCPEVLEKVDVMVDGGIRRGTDVVKALCLGARAVGIGRPAFWGLGAGGIAGVERTLQSKCFISAPIVGSECSGADFSFSKVLAQETRTCMSLLGVRRVPDLGIRHVNARIVEQQIYNMDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPT4</accession>
    <name>A0A0G4PPT4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Armadillo-type fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S026g000036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793159">
        <property type="protein sequence ID" value="CRL28171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PPT4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PPT4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010265">
        <property type="term" value="P:SCF complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039852">
        <property type="entry name" value="CAND1/CAND2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12696">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL28171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="303" mass="32391" checksum="D96F84D94C2A077F" modified="2015-09-16" version="1">MADRQVTQQTIFTLLSKLDDPDADLRYMSLNDLYGILTNPNSSFLSHDRGTSTNLAEGLLKALDDQHGDVQNQALKCLGPLAVRLPFESLTPLLEQLASLTASQTIDTSVPNTALRVIVDTLPRPQSGQPASQNAITAYTAVSKVLVPRLTGPTPSGTGRRGSMVKSMMEKDPSRGFSSDAIDVLIKVVTCFGPLLRESELAALQVSVMAIIQNDTAGTVVTKRALAAISALVLHFSDNQLNGFVSNLTKTLSSNISMVQRRHLIAAIGVIARTAPAKFGPHLDTLAPFVFSAVGEDNITRAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQ59</accession>
    <name>A0A0G4PQ59_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S028g000125</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="HG793161">
        <property type="protein sequence ID" value="CRL28572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQ59"/>
    <dbReference type="STRING" id="1429867.A0A0G4PQ59"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
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        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="7">
        <location>
            <begin position="105"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL28572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="303" mass="33849" checksum="ADA9B3E4753E91E5" modified="2015-09-16" version="1">MPDGTELDPPKTSPSVITSADIEPPSSISDPKIRKKLRGPNVNSNDEDGDSSSRSRSSSNTSADLQLNRNFVFLGDYVDRGYFSLETLTLLLCLKAKYPDRVTLVRGNHESRQITQVYGFYEECFQKYGSASVWKACCQVFDFMTLGAIIDGKVLCVHGGLSPEIRTLDQVRVVARAQEIPHEGAFCDLVWSDPDDVETWAVSPRGAGWLFGDRVADEFCHVNDLSLIARAHQLVNEGYKYHFNNQNVVTVWSAPNYCYRCGNLASVCEIGEDLKPSFKLFSAVSDDQRHVPTSRPGRSEYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQ96</accession>
    <name>A0A0G4PQ96_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCA7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S027g000012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793160">
        <property type="protein sequence ID" value="CRL28323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQ96"/>
    <dbReference type="STRING" id="1429867.A0A0G4PQ96"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904802">
        <property type="term" value="P:RITS complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013243">
        <property type="entry name" value="SCA7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037804">
        <property type="entry name" value="SGF73"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47805">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47805:SF1">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08313">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51505">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCA7" evidence="2">
        <location>
            <begin position="197"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL28323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="394" mass="42206" checksum="2037FEF656FB24A5" modified="2015-09-16" version="1">MANNGDPGQGRGSLVDASGYTFTDKDTKPGKIKVKKTSKASTKKKADEAKDGPIDTSPTASPLPTLDSKVVSVFPTGKPREDDLLETVICKHCKRPTLKQTAADHVRGCLKAKQEKARKKKEARDAANRLKAGDDRDDDGPDKADGETHNMGQKSAKKSATKGTEDGNKKGKKRKADEDDGKESKKKKKKDEPKQKTAKPKGPVDVEKQCGVTLPNGAQCARSLTCKSHSMGAKRSVPGRTLPYDMLLQQYQKKNQARQQKAAIDANAPLQEDIENTGPIDSDEERDAVMAAIARSAPQPLVRHPIITTKSKYRYVRIKEQMSHAMGVRNGGGLFSNDDSQPLFGGILFSTVAADLDSSSVDANGEADVSAGGMDAGKRSSISGNHKTPVTGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PR83</accession>
    <name>A0A0G4PR83_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S031g000078</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793164">
        <property type="protein sequence ID" value="CRL28910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PR83"/>
    <dbReference type="STRING" id="1429867.A0A0G4PR83"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL28910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="393" mass="44402" checksum="BC55B971AE271048" modified="2015-09-16" version="1">MVYRRSHNKSRHGCTNCKRRRVKCDEQRPNCTICTQRQEECVYSSEVPYFFAGKQSRKPLRNKQSPTTGQTSNATSVSEDEASALLHQIGSAQVSTGPALNMEELELELQWIMQTHKLLARNEETRKVWEILVLQEALHEPFLMHGILGLSALHLSHLRADKSQAKWLGIAMSHKNVAISMFSEQLSNIDRSNVKAMMSFAGLVVAFGLGSALTSGSPEGPTLNSLIEIFTLSRGVQSVVNAEPEFLLQSNFAPLFDVTPPQVSWPDHVLTAFDRLEKLNVQCGQQYAHHNTAVYERVIKYFRELAVFTLLQPTSMTLAGGFAIRAPEVYLSDLTSRQLYSLVVLAHYCGFLHMARENWCVGSWGRVVLEEIQQLLPPDWQHHIEWPVKQVCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRF0</accession>
    <name>A0A0G4PRF0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutathione S-transferase, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S032g000035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793165">
        <property type="protein sequence ID" value="CRL28999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PRF0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PRF0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03038">
        <property type="entry name" value="GST_N_etherase_LigE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054416">
        <property type="entry name" value="GST_UstS-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22041">
        <property type="entry name" value="GST_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="13"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL28999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="242" mass="27566" checksum="3DADF38DD3987304" modified="2015-09-16" version="1">MATQPEPEIVLYDLACTRHVSFSPVVWRIRLMLNYKNIPYKTIFLEFPDIEPTLRNLGLVPGEASKYTVPAIQHVPTNTYIMDSLPIAQFLESTYPDPPVPLTSDLGREIETKARGVLGKAIYSSVMPREINILSLRSQEYFRRTREAALGHRLEDLLDGDKEERVWEGVSDAMRAIGELMRTNKADGPFVLGARPSYTDFFIAGSLQSVRVIDEGVFQRMIKYPGYGEVYEACLPYLERRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRQ4</accession>
    <name>A0A0G4PRQ4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphotransferase</fullName>
            <ecNumber evidence="12">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S033g000039</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="12"/>
    <dbReference type="EMBL" id="HG793166">
        <property type="protein sequence ID" value="CRL29119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PRQ4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PRQ4"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046323">
        <property type="term" value="P:D-glucose import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990539">
        <property type="term" value="P:fructose import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1250:FF:000001">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000092">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000004">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019807">
        <property type="entry name" value="Hexokinase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF16">
        <property type="entry name" value="HEXOKINASE TYPE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00378">
        <property type="entry name" value="HEXOKINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 12 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="13">
        <location>
            <begin position="27"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="14">
        <location>
            <begin position="227"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CRL29119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="490" mass="54094" checksum="30F89F50457A74A6" modified="2015-09-16" version="1">MVGLGPKHPHSRKGSMHELPQNLLEPIKEFEKAFTVDRSKLKEIVNHFVKELEKGLSVEGGNIPMNVTWVLDFPDGHERGTYLALDMGGTNLRVCEITLTEEKGAFDITQSKYKMPEELRTGTAEELWEYIADCLQQFVETHHAGESLTKLPLGFTFSYPATQEYIDHGILQRWTKGFDIDGVEGKDVVPPLEAILKKRGLPIKVAALINDTTGTLIASSYTDSAMKIGCIFGTGVNAAYMENAGSIPKLAHMNLPADMPVAINCEYGAFDNEHVVLPLTKYDDIIDRDSPRPGQQAFEKMTAGLYLGEIFRLALIDLVDNRPGLIFNGQDVTTLRKPYLLDASFLAHIEEDPYENLTETLDLFDSKLSIRPTEPELELIRRLAELIGTRAARLSSCGVAAICTKKNIESCHVGADGSVFTKYPLFKERGAQALREILDWAPTEKDKVSIMAAEDGSGVGAALIAALTLKRVKAGNLVGIRNMDDMKTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PS55</accession>
    <name>A0A0G4PS55_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase, DXD sugar-binding region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S031g000099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793164">
        <property type="protein sequence ID" value="CRL28931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PS55"/>
    <dbReference type="STRING" id="1429867.A0A0G4PS55"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.20:FF:000004">
        <property type="entry name" value="Glycosyltransferase family 32 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF8">
        <property type="entry name" value="TRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL28931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="389" mass="44618" checksum="CAB0EFA2A76E5CA1" modified="2015-09-16" version="1">MLEKNFAVRSLFPKKARRFTHGGLVALCLFIYFCVTRTSHDFVKNQSYSTQLTGNIGGQFPRKIWQIWKVNPLEFDGRDIEVARSWISKNPGYRYEVLTDQNDLDYVEANFGPLGMNRPDIVRTYRSLTAPIIKADLLRYLVLYIEGGVYADIDVEALRPVERFIPNSHDENEINMVIGVEIDEPHFRDHPILGQKSQSFCQWTFMCKPRQPVMMRLVENILEWLNQLSIEQGRPISELQLDFDDVITGTGPSAFTSAILSEMSRATGKQVTWNMFHDIPESKLVGGFLVLTVEAFAAGQGHSDSGTHNSRTALVKHHYHASAWPDRHPRFYHPIFGQVERCNWDVDCVRKWDEETSAFAALPQEEQERQITTFQAIGEALKNMQPPPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-11-27" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PTQ5</accession>
    <name>A0A0G4PTQ5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">rRNA methyltransferase 2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S037g000008</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793170">
        <property type="protein sequence ID" value="CRL29521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PTQ5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PTQ5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF18">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005461">
        <property type="entry name" value="23S_rRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="9">
        <location>
            <begin position="49"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL29521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="278" mass="31423" checksum="4CADBCD14F36079E" modified="2015-09-16" version="1">MFALRSIRFSQNACHWQAIGQARHASSKRWQARQQKDQFTREAAVQGLKSRAAFKLLQIDEKYRIFRAGQTVVDLGYAPGSWSQVAASRTQPHGRVLGVDIIPAQPPKGVSTIQGNFLAPEIQTYIRDFLRSPDRGRPRQPGFLDDSSVSLLEPNSDTERTIEAEKTEMRGDKILERTVDVVLSDMSAPWHQTSGFWKRSLSAPYNRMMNTSGVSFRDHAGSMDLCHAALRFSSDVLKAGGHFVCKFYQGAEDKELEQQLKELFKKVHRLKPESSRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PU64</accession>
    <name>A0A0G4PU64_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thiolase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S040g000062</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793173">
        <property type="protein sequence ID" value="CRL29836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PU64"/>
    <dbReference type="STRING" id="1429867.A0A0G4PU64"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040771">
        <property type="entry name" value="TLP1_add_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF139">
        <property type="entry name" value="THIOLASE-LIKE PROTEIN TYPE 1 ADDITIONAL C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18313">
        <property type="entry name" value="TLP1_add_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase-like protein type 1 additional C-terminal" evidence="4">
        <location>
            <begin position="432"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL29836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="522" mass="57031" checksum="3E7670827B9B8E26" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-11-27" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUN9</accession>
    <name>A0A0G4PUN9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AA9 family lytic polysaccharide monooxygenase</fullName>
            <ecNumber evidence="5">1.14.99.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endo-beta-1,4-glucanase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glycosyl hydrolase 61 family protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S045g000009</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Lytic polysaccharide monooxygenase (LMPO) that depolymerizes crystalline and amorphous polysaccharides via the oxidation of scissile alpha- or beta-(1-4)-glycosidic bonds, yielding C1 and/or C4 oxidation products. Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 5">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">Has a modular structure: an endo-beta-1,4-glucanase catalytic module at the N-terminus, a linker rich in serines and threonines, and a C-terminal carbohydrate-binding module (CBM).</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="5"/>
    <dbReference type="EMBL" id="HG793178">
        <property type="protein sequence ID" value="CRL30143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PUN9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PUN9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF2">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195852" description="AA9 family lytic polysaccharide monooxygenase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="7">
        <location>
            <begin position="18"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL30143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="282" mass="30716" checksum="C7A7506F115F02DC" modified="2015-09-16" version="1">MKFSIVALAAIAPMVSAHYFFDTLVIDGKEATDPVRSNTRPMKYNPTKWVNTRDDMTPDLPDFRCNKGAFTFAGQTGTAELKAGSKVAMKLAVGAKMQHPGPALVYMSKAPTTANTYEGDGEWFKIHEESVCDKNKDFTKDAWCTYDKDRIEFTIPSNLPDGEYLIRPEHIGVHGAAGGQAEFYYTCAQVKIVGGGNGTPGPTVKFPGAYKKDDPSFNFSIWNGYKEYPMPGPKVWSGESDSSSASSKVAISNGSAAVTPSSKQAEDSDAFTRCARSCFQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUP2</accession>
    <name>A0A0G4PUP2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S040g000075</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793173">
        <property type="protein sequence ID" value="CRL29849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PUP2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PUP2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF77">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="94"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL29849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="726" mass="81198" checksum="F0AAA81F077A84B7" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUQ5</accession>
    <name>A0A0G4PUQ5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Formate dehydrogenase</fullName>
            <shortName evidence="6">FDH</shortName>
            <ecNumber evidence="2 6">1.17.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">NAD-dependent formate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S044g000002</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>formate + NAD(+) = CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:15985"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.9" evidence="2 6"/>
    <dbReference type="EMBL" id="HG793177">
        <property type="protein sequence ID" value="CRL30071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PUQ5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PUQ5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042183">
        <property type="term" value="P:formate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05302">
        <property type="entry name" value="FDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000057">
        <property type="entry name" value="Formate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03210">
        <property type="entry name" value="Formate_dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033689">
        <property type="entry name" value="FDH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005750">
        <property type="entry name" value="PRK07574.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938:SF9">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="7">
        <location>
            <begin position="181"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="226"/>
            <end position="227"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="282"/>
            <end position="286"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="363"/>
            <end position="366"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="6">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="6">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL30071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="414" mass="45488" checksum="8BCF1C4641AB0D2A" modified="2015-09-16" version="1">MVFIRSLSRQLRRPFLSSSLKPTVASNPFTRVSPLAGSISGARTLTATSNLQGKVLLVLYDGGEHSQQQPKLLGTTENELGIRKWLEDQGHTLVTTSDKEGENSTFDKELVDAEVIITTPFHPGYLTAERLAKAKKLKLAVTAGIGSDHVDLNAANTTNGGITVAEVTGSNVVSVAEHVIMTILLLVRNFVPAHEQIKNGDWDVAAVAKNEFDLEGKVVGTVAVGRIGERVLRRLKPFDCKELLYYDYQPLSAETEKEIGCRRVDDLEEMLAQCDVVTINCPLHEKTRGLFNKDLISKMKPGAWLVNTARGAIVVKEDVAEALKSGHLRGYGGDVWFPQPAPKDHPLRYAEHPWGGGNAMVPHMSGTSIDAQVRYAEGTKNILDSYFSGREDYRPQDLIVHKGDYATKAYGQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVP4</accession>
    <name>A0A0G4PVP4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB/POZ fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S046g000031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793179">
        <property type="protein sequence ID" value="CRL30227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PVP4"/>
    <dbReference type="STRING" id="1429867.A0A0G4PVP4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="55"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL30227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="291" mass="32552" checksum="2BB17DCF4DD067A4" modified="2015-09-16" version="1">MANKKKPSTQRRTLHNHSGSPTFPNEVKDKRIQTTTPGEELLNALSRMRLDPKYSDLTILCSDEVYAVHKCIVCTRSDFFAKACDGGFQEASTDEVMLQEEPALVREMIEYLYTLDYLVSHPLSLPDSSNSSEAPSTNVSEAEDVSADEVVPCQQPEGREDQENASQPDDAPRNPPAAFDPLSFHILMYSLADRMFIEGLKALSNQKAERELIDRLDATSFPHAIFEIYNSTPADDRGLRDMAVRVTMDHLTKLRSGDEGVPVTFNNSLLKSVPQFCFDLLVAIMDKNMSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVQ6</accession>
    <name>A0A0G4PVQ6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="6">1.2.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S050g000038</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>succinate semialdehyde + NAD(+) + H2O = succinate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13217"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>succinate semialdehyde + NADP(+) + H2O = succinate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13213"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.16" evidence="6"/>
    <dbReference type="EMBL" id="HG793183">
        <property type="protein sequence ID" value="CRL30391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PVQ6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PVQ6"/>
    <dbReference type="UniPathway" id="UPA00733"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036243">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000005">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010102">
        <property type="entry name" value="Succ_semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01780">
        <property type="entry name" value="SSADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF5">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="33"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL30391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="502" mass="54228" checksum="3C936D70E797D7B9" modified="2015-09-16" version="1">MSHTVPQDFKVDLYLQLKDKSLFIGKCHINGEWVGAQSGKTFEVTDPATDKVIGTCPEFSAKDTERAIKAASDAFPIFRKTLVRERSRLLRRWNDLILQNLDDLATLITWENGKPFAEAQGEVKYAAAFIEWFSEEAPRLYADTIPTSVPGNRVLTVKEPVGVCGLITPWNFPAAMITRKIGPALAAGCTVVAKSPGETPFTANALAELALRAGIPKGVVNIVTALENTSEVGHTLTTHRDIKKVSFTGSTRVGKLLMGQASSSVKRVSWELGGNAPFIVFDDVKDIDMAVAGALVSKFRGTGQTCVCANRIYIHRSHYKAFAERLVERIKNFNVGPGFAEGVTHGPLIHRAAAQKVADHVADAKSKGARVLLGGGPINELGPAFFQPTVLADMTHDMRIADEETFGPIAALFPFDTEEEVIQLANRCEVGLAAYIFSDNVRRVFRVADALEVGMVGVNTGSVSDVAAPFGGVKESGFGREGSKYGIEEFVNVKSITLGGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVS9</accession>
    <name>A0A0G4PVS9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">proteasome endopeptidase complex</fullName>
            <ecNumber evidence="4">3.4.25.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S051g000019</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="4"/>
    <dbReference type="EMBL" id="HG793184">
        <property type="protein sequence ID" value="CRL30416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PVS9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PVS9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
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</entry>
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            </authorList>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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</entry>
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    <accession>A0A0G4PY78</accession>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="253" mass="29082" checksum="5A2BB2CCEAAA06C6" modified="2015-09-16" version="1">MKSTPIPVQFLYGPAEIALKAILSLRIESPSVWEWTSTSSKNPSPDARMLLDICTDLRSRRSDEGFSLENDLRVYVRDILQHLSYGAVLMLALLTWHFDASSSEASQGLRIFLRPPHNSQVWGILQDRYRSILLSELCKAAANFSKIGIIPDRPTFVHFNTSLSAKLLKGNGIHKFRSLGKKPTSHSFVWLELGVNEEERVTHAQANRRRVFGRDTRVRINREGRGRLFFQHYRHSVARSFMHKLSIRIWASR</sequence>
</entry>
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                <person name="Renault P."/>
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                <person name="Conseiller E."/>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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        </location>
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        </source>
    </evidence>
    <sequence length="79" mass="8543" checksum="571936F3ACEE3E41" modified="2015-09-16" version="1">MPCSLGNGMNASLTIGVVFQGSTFGIRLPTIIITVSFIDDLPVMTDGNKSILQAIPTDITHIVFDRLSLKTETPLVIWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NUE0</accession>
    <name>A0A0G4NUE0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S001g000549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NUE0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL17589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="50" mass="5814" checksum="724BBF81E8A0818A" modified="2015-09-16" version="1">MDWYGVRSTKISINILVGFGQCVLRTEYLAPRPSDSALYFIKYSVHLKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NUG2</accession>
    <name>A0A0G4NUG2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S001g000673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NUG2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL17713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="70" mass="7662" checksum="7D873AAF66D4FCBB" modified="2015-09-16" version="1">MPMPRYKEGDKVSYKPVGGAQSRTSMSTGLILENLGGRSASDDEPRYKIENLHTHKSSNIKEGNIEGPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NVA7</accession>
    <name>A0A0G4NVA7_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="4">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S001g000973</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="4"/>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL18013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NVA7"/>
    <dbReference type="STRING" id="1429867.A0A0G4NVA7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000609">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF40">
        <property type="entry name" value="REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14497)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="6">
        <location>
            <begin position="7"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="7">
        <location>
            <begin position="189"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL18013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="319" mass="35644" checksum="5B45B90F6652FB96" modified="2015-09-16" version="1">MSDQIDVLVYGLGAIGSFYAFILSRSDRVRLTVVARSNYEAVKANGIIINSENHGQHTVHPHRVVKSIADIPPVDYIVCAHKAIDQDEVVAKLQPAIDSKTTIVVIQNGVGNEEPFRKQFPDSSIITCVTWVGATQTSPGIVAHTKSEDMQIGLFPNPKVENQVEQKRLETFADLLRNGKTRFQVLEDMQIQRWEKVVWNVAWNSLTTLTMVDTQSWLNSSEDAMPFTRQLMQEVINIARACGVPLKDDLIDQLMDKINAMPGIGSSMQTDCKSGRPMEIDVILGFPVRKSRELGIQAPYLETLYVLLRAVDGRLRAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NVX9</accession>
    <name>A0A0G4NVX9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="20">NAGK-NAGSA, bifunctional</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PCAMFM013_S002g000090</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FM 013</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2 17">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">In the C-terminal section; belongs to the NAGSA dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">In the N-terminal section; belongs to the acetylglutamate kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NVX9"/>
    <dbReference type="STRING" id="1429867.A0A0G4NVX9"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
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</entry>
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    <accession>A0A0G4NW58</accession>
    <name>A0A0G4NW58_PENC3</name>
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        <submittedName>
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        </submittedName>
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    </gene>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005194825" evidence="1">
        <location>
            <begin position="17"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL18308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="190" mass="19958" checksum="89331D2B732918C2" modified="2015-09-16" version="1">MKFTLTTLALPLLAAAAPITEPAANPAFSVMAIRSASPIHYLQLNAAGQKFYLGGKTASYCPTQVPQCPPGNQTVFAPGGSSLDTMVPGGQQVYIDPNGALSFTQAHSANIPQGSSLGPFKYAADEPWAHYSFAGWGATGFMACPADDNRWQVFAAIKNATVPHGNVNECLGFSAVALTYTGDVPAWQYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NW76</accession>
    <name>A0A0G4NW76_PENC3</name>
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        <submittedName>
            <fullName evidence="7">Zinc finger, C2H2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S002g000119</name>
    </gene>
    <organism evidence="7 8">
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <authorList>
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                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
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    <dbReference type="STRING" id="1429867.A0A0G4NW76"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
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        <property type="entry name" value="Znf_C2H2_jaz"/>
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    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF295">
        <property type="entry name" value="AZ2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="142"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL18249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="331" mass="38602" checksum="DAD44278B03CA782" modified="2015-09-16" version="1">MYECGTCDFEFRYREDCDAHMDEYDHWVECETCSRQFRTEGSCEQHMDALDHRAPVFECETCPRQFRTERSCEQHMDALDHREPAFECETCTRTFSSQAAANQHMNVKNHWEPTVSCETCSQMFHTHEAADQHMEAEGHYENYCAECDRRFMNENCLRQHLNSKIHRGTEVVCPFCKAHFVTAGGVTHHVESGTCPKAAKWNRETIHRMIQRLDPNGLVTNKQIGWHNDENVRYYATDRAFDGTSWVCYLCQRGFSSMTGLNSHLNSPFHREKIYHCLNTRGGCNKEFNSLGALFNHLESESCGYIRFGDVQRVHRRLNDAILNRKVITSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWP1</accession>
    <name>A0A0G4NWP1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S002g000219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWP1"/>
    <dbReference type="STRING" id="1429867.A0A0G4NWP1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF80">
        <property type="entry name" value="GRIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="899"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="100"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="342"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="814"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="899"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="952"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1019"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1068"/>
            <end position="1079"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL18349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1079" mass="119660" checksum="725B8F835BD35165" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NX37</accession>
    <name>A0A0G4NX37_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="19">NADH:cytochrome b5 reductase (CBR)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PCAMFM013_S002g000486</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NX37"/>
    <dbReference type="STRING" id="1429867.A0A0G4NX37"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000019">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF178">
        <property type="entry name" value="CYTOCHROME-B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0274">FAD</keyword>
    <keyword evidence="5 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 16" id="KW-0349">Heme</keyword>
    <keyword evidence="12 16" id="KW-0408">Iron</keyword>
    <keyword evidence="14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="17">
        <location>
            <begin position="4"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="18">
        <location>
            <begin position="225"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CRL18616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="469" mass="50714" checksum="578D284E42186DAD" modified="2015-09-16" version="1">MAANKVFSVDDVASHKDRTDLWVIIHGKVYDLTKYVRDHPGGADVLYDVAGVDASEAYDEVGHSEDADEILKTFLIGTVKDAQEVKAPKKVVRLIQATTPKKENTTASGSSAGAVTLVIGSIAGGAALYLASQHNFKLQHLLSKLPLPSAGSLRSTPTFALPQGGFFTGFTAATSLCVTIGAVIAAKLSKFTQIESGFTKYPSHLKSQPVVKADPGLARGFLQPKEYQALPLVKKEQLSPNVFRFVYQLPNQTDVIGIPIGQHCAIKANIEGKDVARSYTPTSNNTDLGRLELVIKCYPDGLLTGKYLANLKVGDKTLFRGPKGAMKYKNGLCKKIGMVAGGTGITPMYQLIRAICEDETDTTEVSLILANRSEEDILLRKELEAFANNYPKNFKLWYMLDKPPQNWAYGKGFVTQAVMTAKLPAPSPDTKVMLCGPPGMVKAAQTALVSMGFQAPGSITKMTDQMFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXM2</accession>
    <name>A0A0G4NXM2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S002g000693</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NXM2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL18823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="38" mass="4424" checksum="F3C0FD89704CC0EC" modified="2015-09-16" version="1">MTDEETAPYTPELKTPPHSDYYNFEPDVVHFLHCLNAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXN1</accession>
    <name>A0A0G4NXN1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Anp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S002g000708</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ANP1/MMN9/VAN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NXN1"/>
    <dbReference type="STRING" id="1429867.A0A0G4NXN1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000017">
        <property type="entry name" value="Mannan polymerase II complex ANP1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052086">
        <property type="entry name" value="Mannan_Polymerase_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083">
        <property type="entry name" value="MANNAN POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083:SF4">
        <property type="entry name" value="N-GLYCOSYL-TRANSFERASE (AFU_ORTHOLOGUE AFUA_4G06870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03452">
        <property type="entry name" value="Anp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL18838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="412" mass="47079" checksum="DA36B4BA15866D72" modified="2015-09-16" version="1">MLLPKGGVNWKSAKARLPPWRAVIVLLTRTRFLVSIALTGLLILMWRGVSRSASEMQSFYCYGSNKSPMEMSINEMVEWSAHAQTPVLFNRHEPYEVNSTSITDLDLNPIKSTSKAALNRERVLILTPLRDAAPYLAKYFDLLYKLSYPHELIDLAFLVGDCKDDTLANLASELDRIQNHAEEKIRFRSATVIQKDFGADVEMSVAERHSFAAQGPRRKAIARARNYLLYSALKADHSWVYWRDVDITDCPERILEDFMAHDKDILVPNIWFHRYNQDGHDIEGRFDYNSWVESDKGRRLRASLPTDTVLAEGYKEYDTGRTYMVSMGDWRNNKDDEVELDGIGGVNILVKADVHRSGINFPAYAFENQAETEGFARMAKRAGYQVVGLPNYVVWHIDTDEKPGNLGDRKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYS1</accession>
    <name>A0A0G4NYS1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S002g001078</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL19208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NYS1"/>
    <dbReference type="STRING" id="1429867.A0A0G4NYS1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF11">
        <property type="entry name" value="AMIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="5">
        <location>
            <begin position="96"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="3">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="248"/>
            <end position="251"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL19208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="560" mass="60798" checksum="6E846978A86D7608" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZE2</accession>
    <name>A0A0G4NZE2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome b5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S003g000231</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZE2"/>
    <dbReference type="STRING" id="1429867.A0A0G4NZE2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF82">
        <property type="entry name" value="CYTOCHROME B2, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G07200)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="7">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="8">
        <location>
            <begin position="98"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL19440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="467" mass="49543" checksum="787221D335615218" modified="2015-09-16" version="1">MAGIMLSLSDIQTHRVEGDCWIAIHGNVYDVSSFLNSHPGGKAILLQHAGTDATRAFQDVHPAEMLDEYLTSGQLLGQLESASQDLRDDGQPEHIPAPPMGTILSIAEMESLALNRLSPKALAYYASGTDDEITKLANGAIFKSILLRPRVFVDCTKCSLSTTILGNIVGLPIFISPAAMAKLANPSGEIGIAAACSKFNALQIISKNASVSVADIVRAGPHAVFAWQLYVLKDIKATERTLAQIKAIPQIKFIVLTLDAPFPGKREADERYKAEEVAGGGVSQVWGTESGLTWRKALTWLSAHTDLPIVLKGIQTHEDAYAATMFPAVKGIVISNHGGRALDTANTPMQVLLEIGKFCPQVFDQVEVLIDGGIKRGTDVVKALALGARGVGLGRAALYGLAVGGEEGVHRSLQILAEEAATAMRLIGVSSVSDLRPQHVNTSILNAQLYDGPSGLDAVGSSLMAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZP2</accession>
    <name>A0A0G4NZP2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized conserved protein UCP028035</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S003g000318</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZP2"/>
    <dbReference type="STRING" id="1429867.A0A0G4NZP2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046539">
        <property type="entry name" value="DUF6604"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016864">
        <property type="entry name" value="UCP028035"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795:SF1">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20253">
        <property type="entry name" value="DUF6604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028035">
        <property type="entry name" value="UCP028035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6604" evidence="2">
        <location>
            <begin position="9"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL19527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="982" mass="111661" checksum="E3B99D5FE989F030" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZX0</accession>
    <name>A0A0G4NZX0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Succinate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S003g000406</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>succinate semialdehyde + NAD(+) + H2O = succinate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13217"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 8">
            <text>succinate semialdehyde + NADP(+) + H2O = succinate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13213"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.16" evidence="8"/>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZX0"/>
    <dbReference type="STRING" id="1429867.A0A0G4NZX0"/>
    <dbReference type="UniPathway" id="UPA00733"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036243">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000005">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010102">
        <property type="entry name" value="Succ_semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01780">
        <property type="entry name" value="SSADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF11">
        <property type="entry name" value="SUCCINATE SEMIALDEHYDE DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="23"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL19615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="498" mass="53189" checksum="A885248FAABBB745" modified="2015-09-16" version="1">MATNIQLKDPSLLIGQNYIDGKWVEAESGKRFNVTDPASGKLIGSCPESDTRDAQRAIDSAAAALPAWRSRAGRNRSRILRRWYELVMENQEDLATLITWENGKAKPDAAGEVLFAASFLEWFAEEAARIYGDVIPHTQPSFRVSVLKEPIGVCGLITPWNFPAAMITRKLGPALAAGCTVVVKTAGETPFTANALLKLGERAGIPAGVINSVAALANTPEIGQALCSSNTVRKISFTGSTRVGKLLMQQSSNSLKKLGLELGGNAPFIVFEDADLGLAVDAAIGSKFKSSGQTCVCSNRIFVQESIYPEFIRRLKSAVSQFQVGNGFDKKTTHGPLVTSAAVERVAGLVDDAVKRGAKVEIGGKRRADLGPNFFEPTILTNVSAEMTVVNEEIFGPVAPIFSFKTEDEVVATSNACDVGLASYIFTQDVTRANRVSELLQFGMVAVNTGVISDAASPFGGIKHSGMGREGSKYGIDDYLHTKTVVTGNVNVVHKASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P008</accession>
    <name>A0A0G4P008_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S003g000419</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P008"/>
    <dbReference type="STRING" id="1429867.A0A0G4P008"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195134" evidence="7">
        <location>
            <begin position="21"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="209"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="287"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="217"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL19628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="373" mass="38964" checksum="423C617E83A45AF8" modified="2015-09-16" version="1">MAGLRLIGLLTLSLLPWVEALPSFTPIPTTFRHPVTPTPIPALTEALYRRGSSTPATADSMSYVPESVCGYKGAILNKKNLIYCNNNHKCVFHAPNSTFGGMVGCCPPSNSDGCSFATMCYDRNELPASPALRSSTDPFILACTASDRPYCVTYTYAKMDMTNYNCGTTPFLATLYTWATSFESGVGLVMATKSVDTVDDAFLSSWMSRGHTPSDVPNATPTTSSTSAGSPNTGSPDTGSSNGSGSSISAGAIAGSVVGSVVAVAGIVTAGFVFFLLKKRKQQRNDVVASDNAQDGYQSGPKHGSPSGGELHQPVNVDGVPTGKVFEAEGNGPAHKSPGVEGSDPVNVAHEMDGSHFIAELPAREKGTSTELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0A5</accession>
    <name>A0A0G4P0A5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40/YVTN repeat-like-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S003g000531</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat LST8 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P0A5"/>
    <dbReference type="STRING" id="1429867.A0A0G4P0A5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000923">
        <property type="entry name" value="Protein transport protein (LST8), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037588">
        <property type="entry name" value="MLST8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842">
        <property type="entry name" value="G BETA-LIKE PROTEIN GBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842:SF0">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX SUBUNIT LST8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="145"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="186"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="277"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="406"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="374"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL19740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="467" mass="51547" checksum="13EA567826134659" modified="2015-09-16" version="1">MAENGTPSDVRPRPSRLDSSPNASRDSSGTQNEDITKTGYFSHYTPLASALVNMSVILCTGSTSRAQRLCSTHGVAICTRTLADYIAASFWEALSGICSRTIQHPDSQVNRLCITPDKRFLAAAGHNNVKLFDIKSTNPNPVITFEGHTNNITGVAFHCEGKWMVTSSEDGTVKVWDTRTGSLQRNYVHRAAVNDVVIHPNQGELISGDHAGMVRVWDLGESVCTHQLIPEEDTAVLSVSVASDGSLLCAGNKKGNVYLWRMVQTDETTRIIPVCTFQAHKDYLTRVLLSPDVKHLATCSADHTAKVWNLDAEFPPAKLALKQWKEKEALNPPVETPVEAPITPVEVPAQSRDLLRIFDAPVQDRDLLRITDNPPRQETPQQTFTSSPDGPPMDPVNHTLFLETTLANHQRWVWDCAFSADSAYLVTVSSDHYARLWELGTGNIIRQYSGHHRGAVCVALNDYSEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0E3</accession>
    <name>A0A0G4P0E3_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Molybdenum cofactor biosynthesis protein 1</fullName>
            <ecNumber evidence="6">4.1.99.22</ecNumber>
            <ecNumber evidence="7">4.6.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">PCAMFM013_S003g000578</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Isoform MOCS1A and isoform MOCS1B probably form a complex that catalyzes the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP). MOCS1A catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate and MOCS1B catalyzes the subsequent conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cPMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:49580"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.6.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>GTP + AH2 + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + L-methionine + A + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49576"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.1.99.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="22">Isoform MOCS1A and isoform MOCS1B probably form a heterooligomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the MoaC family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the radical SAM superfamily. MoaA family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.22" evidence="6"/>
    <dbReference type="EC" id="4.6.1.17" evidence="7"/>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P0E3"/>
    <dbReference type="STRING" id="1429867.A0A0G4P0E3"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21117">
        <property type="entry name" value="Twitch_MoaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000117">
        <property type="entry name" value="molybdenum cofactor biosynthesis protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01225_B">
        <property type="entry name" value="MoaA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013483">
        <property type="entry name" value="MoaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040064">
        <property type="entry name" value="MoaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010505">
        <property type="entry name" value="MoaA_twitch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050105">
        <property type="entry name" value="MoCo_biosynth_MoaA/MoaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02666">
        <property type="entry name" value="moaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22960:SF0">
        <property type="entry name" value="MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22960">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SYNTHESIS PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06463">
        <property type="entry name" value="Mob_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01383">
        <property type="entry name" value="cyclic_pyranopterin_phosphate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01386">
        <property type="entry name" value="main_SPASM_domain-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01067">
        <property type="entry name" value="SPASM/twitch_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="19" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="13" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Radical SAM core" evidence="23">
        <location>
            <begin position="64"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00054222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00063038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CRL19787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="419" mass="48013" checksum="E67762C03D4CB4B8" modified="2015-09-16" version="1">MAERGLARRIAPLIQLSQNFRTQGNFRDSGVGRRYLGIPSEPPQHQRSFEEQTVRPFSDFLTDKFHRQHDYLRISLTERCNLRCLYCMPEEGIDLSPQPQLLTSPEIVYLSSLFVSQGVTKIRLTGGEPTVRKDIVPLMQEIGKLRKDGLQELCLTTNGISLHRKLDQMVEAGLTGVNLSLDTLDPFQFQIMTRRTGFEAVMKSIDRILEMNRVGASIKLKINCVVMRGLNDREIIPFVELCRKKPIEVRFIEYMPFGGNKWNKGKMFSYQEILAVIRERYPTLVKLHDHKNDTSKTYQVPGFKGYVGFITSMTHNFCGTCNRLRITSDGNLKVCLFGNSEVSLRDIIRKENHGQPIDEEALKRLCLLDTIQENRGLASEREHEILDIIGMAVKRKKAKHASMDELKNMKNRPMILIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P0H9</accession>
    <name>A0A0G4P0H9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Catalase-like domain, haem-dependent</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S003g000580</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P0H9"/>
    <dbReference type="STRING" id="1429867.A0A0G4P0H9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08157">
        <property type="entry name" value="catalase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000001">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF26">
        <property type="entry name" value="CATALASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="11">
        <location>
            <begin position="8"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL19789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="503" mass="56840" checksum="D06E12B40261D31E" modified="2015-09-16" version="1">MSADKYYTLAEGCPFASNSTAVLMRNREGGGLGLLQDTQLIETLAHFSRERIPERVVHAKAVGAYGEFEATADCSDLTSASFLNKVGKKTPVLLRVSTVGPESGSADTSRDVHGWGMKLYTDEGNQDWVFNNTPVFFIRDPIKFPSMNRSHKRHPQTHLPDANMFWDFHVGNPEGIHQLLVLFSDRGTPRSVRFLNSYSGHTYKFTKEDGSFKYIKIQMKTQQGIKNFTQEEATKIAGEGPDYMIRDMFEAIERKDYPSWDVFVQVMDPSEAENYRWNIFDMTKVWPHKDFPLRKIGKMTLNRNPGNYFTDIEQASFSPSTMVPGFAASADPVLQARLFAYPDAARYRLGVNYQQLPTNAAKVPVYCPFQRDGKMRFDDNYGGDPNYVNSSLQPTKFYPEVKGVSPESLSLHTEHEKWVGEVAAYSSRIKDDDFVQPAALWDVIGRDPGHQERTIDNLAGSISGVKSPRLRNEVYALFSRVNQDLGNKVKRATEASIKDRSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P120</accession>
    <name>A0A0G4P120_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Flavin-containing monooxygenase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S003g000814</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL20022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P120"/>
    <dbReference type="STRING" id="1429867.A0A0G4P120"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000228">
        <property type="entry name" value="FAD-containing monooxygenase EthA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051820">
        <property type="entry name" value="FAD-binding_MO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43872">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43872:SF1">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL20022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="501" mass="56935" checksum="D6C765017B6F6428" modified="2015-09-16" version="1">MNGINGINETKHFDIIIVGAGISGINAAYRVQDQLPGYSYTILEARTDLGGTWDLFKYPGIRSDSDLFTFGFQFNPWSRDNPIAEGSAIKEYVRDTATKYGIDKHILYNHRLSSADWSSDENTWSLAVDHNDSQHTYTARYVIFGTGYYNYKDPLKADIPGLDVFQGQIVHPQFWPEDLHYKDKKIVIIGSGATAVTLLPNLADHAARVTMLQRSPTYILSVPNRSRSRWLSYLLPNALYSRMQRMIWIYTTRIFFLFCQRFPNFARWLLKLNVRKQLPNHIPYDPHFKPRYNPWEQRLCVCPDGDLFRSLRQGKADVKTDTIREVTKDGIILNSGEQLEADIIITATGLRLQIAGGSALSVDGRKIDVGDKYLWNGIMLQDLPNAAFVIGYTNASWSLGSDATALFVCRLLKELESRKLVAAVPRLKEKDAATLQDRPLLNLKSTYVSLAERVLPKAADRGPWQPRDHYLKDLKFAHSGDIDTGLEFVQGPNLRLRPKMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P1V0</accession>
    <name>A0A0G4P1V0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S004g000188</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P1V0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL20248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="121" mass="14105" checksum="DFA4BB84D5AD21EC" modified="2015-09-16" version="1">MMQPGMFRYKFGGPGLPEWEVRDYECVYFVTVHFHERYRSYSSEKLMQSMIRRIKDGEAEVSLKPLHRLTPRCISMPVYGPYDAPSAVILATAREVSEKQLNEIHQGFVEIDMDLVFGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P1W3</accession>
    <name>A0A0G4P1W3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S004g000219</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P1W3"/>
    <dbReference type="STRING" id="1429867.A0A0G4P1W3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="97"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL20279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="438" mass="48174" checksum="F629B4D211BB5F2D" modified="2015-09-16" version="1">MPTLCIDPQGPLSTLPKELYLTISDFLPSSSDLNAFTCTNTTTYNLLNKPLYKRDATSPNPKSLFWASTTDTPSTALKSLSAGFDIQSKTDTDPRLKGCTPIMLAALHNSIAVLKLLLLNDEANPNTRDRKWIRPPLSWAVKEGHSAIVQTLLNDDRTDVNLQDKTGDTALMMAVNHQPKMMTLLLCSGRADPRVQNRQGWTPLSRAAREVDGDVGLLLANHLRLILDGDGGAVHCQHVFFYAAIMGHVDIVRYLVKYFGEKLDPNAEGQQYGRGAFSIAASAERVDVVQFLLEWEVTDPNLQTHWKRQTPLFVAAENGHEEIVGLLVGCERVGLEIPDMHGTTPLGVATERNHEGIVRRLLTGSRRADPNARDENGQTPLFNAAFYGHIGVVELLLETPGIDPQLGDTDGKTPLEVALENDNQQVVEALRKYIGSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P1X9</accession>
    <name>A0A0G4P1X9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger, GRF-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S004g000218</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20278.1"/>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="232" mass="24648" checksum="988EBD03F50D9CBC" modified="2015-09-16" version="1">MFILTTISALLSVTTAHSTVGHQEHGVACADVHMMLARGTTESYPGLLGTLTDKVLDAIPGSDYENIIYPATQEGSTPSYGEGIRNGTAQLKRYARACPESKIVLLGYSQGAMVVSDMLAGSGDDGTLGALSHPTVNSRTLGSHITAIVLYGDPRHMPNQTYNVGDVAATGKYPRTHQQVLALSAYANRLHDFCNDKDGVCDAAGTNLSAHMAYATIWDTTAASWVVNMLEK</sequence>
</entry>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </feature>
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            <end position="467"/>
        </location>
    </feature>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL20475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <sequence length="628" mass="71302" checksum="CAB0DE57FAA08588" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2Q6</accession>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Vid27_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913:SF0">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08553">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
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        <location>
            <begin position="239"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar import/degradation Vid27 C-terminal" evidence="2">
        <location>
            <begin position="425"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="770"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="790"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF17747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL20528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="800" mass="89843" checksum="558F1134C7A747F3" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2T1</accession>
    <name>A0A0G4P2T1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sorting nexin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S004g000573</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
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            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
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    </dbReference>
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        <property type="term" value="P:endocytic recycling"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="21"/>
            <end position="138"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CRL20632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="142" mass="16773" checksum="4FC85B65648D18EC" modified="2015-09-16" version="1">MQSVPESRQQSFEEIYGPPENFLEIEVRNPQTHGTSRNMYTSYEIVCRTNIPAFKLKHSVVRRRYSDFEYFRDILERESTRVTIPPLPGKVFTNRFSDDVIEHRREGLQRFLQIVAGHPLLQTGSKVLASYIQDPNWDRNAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P316</accession>
    <name>A0A0G4P316_PENC3</name>
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        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S004g000640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P316"/>
    <dbReference type="Proteomes" id="UP000053732">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL20699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="211" mass="23466" checksum="CFEF56EFC6A84C27" modified="2015-09-16" version="1">MLKRMGVTWCGGLRPHLVPQASAPLLIVTMQLEVQDETRPGTVEGQLVLETFTFTGPHRRACISHKLLVQGHRTVSDFINVASKANLTPCDFYFFIYQLARYNVLFLPNDEAARVYDMFNWKYKVGAGSIRQDMHCTAFNQNYRHVNIPGCVTTVITCPSDSGVLPPAGGAAHWKILTLAVLSYTFKATPGVDMQAPIRVLQSVSQLRAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3B8</accession>
    <name>A0A0G4P3B8_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase delta subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S004g000741</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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    </dbReference>
    <dbReference type="GO" id="GO:0043625">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.20">
        <property type="entry name" value="DNA polymerase delta, p66 (Cdc27) subunit, wHTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="POLD3"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR17598">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR17598:SF13">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09507">
        <property type="entry name" value="CDC27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="64"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="177"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="286"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="371"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="385"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="415"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL20799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="439" mass="48109" checksum="3B17B4937BE3DED3" modified="2015-09-16" version="1">MDSKLYLAENVLNERRPVTYRLLSRALKVHANRAKQILFEFHRNENAKKPQTVHATYVISGIQKAPEPAPTNGHADDEDEMMQSSPYLPSSMPNQDAASDSIRTTSIVLAREEDLEDAKSTFQSISTIHVYSLQPTALPDLNVLVDANREIASTHGQEDPLECGKQWGMIQNRNVKRRTGARPPPPAAPAVKPPAAKASKPSTESTVPAKRPLQKETSSVKTEATKPDEPKSEPSSAANSQASSKPSGKAAAPKQKGNLFSSFAKAKPKTKAPAPAEPAAPSAEDVVLDDASEEEAEELFPDSTAKAAAENRENRKEREERLKKMMDDDDDEADDEEMPDADEEPREPTPVEQPPPPKPAELKEEVTVQGGRRRGKRQVMKKKTVKDEEGYLVTREEATWESFSEDEPVPKKKPAVNVPKAKAGKAAGQGNIMSFFGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3R9</accession>
    <name>A0A0G4P3R9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP adenylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S005g000098</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL20934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P3R9"/>
    <dbReference type="STRING" id="1429867.A0A0G4P3R9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003877">
        <property type="term" value="F:ATP:ADP adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009163">
        <property type="entry name" value="Ap4A_phos1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043171">
        <property type="entry name" value="Ap4A_phos1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045759">
        <property type="entry name" value="Ap4A_phos1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019200">
        <property type="entry name" value="ATP_adenylylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420:SF3">
        <property type="entry name" value="5',5'''-P-1,P-4-TETRAPHOSPHATE PHOSPHORYLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420">
        <property type="entry name" value="AP-4-A PHOSPHORYLASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19327">
        <property type="entry name" value="Ap4A_phos_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09830">
        <property type="entry name" value="ATP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ap4A phosphorylase 1/2 N-terminal" evidence="3">
        <location>
            <begin position="7"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="ATP adenylyltransferase C-terminal" evidence="2">
        <location>
            <begin position="212"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL20934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="353" mass="38381" checksum="1AA696F378303C0C" modified="2015-09-16" version="1">MQLGLSESLPTLVARRFTAAKDTGHLVFSSTHLSIINAAGISYQLRYCPALAKKPSNLKPDNGPKTPKPDPFENPSPDLLIAQFPPENPTYNLILNKFPVIPNHFLLVTKDWQAQTDILDKADLEATYECLKAWNTDDDGSRSATGSSSKSLFAFFNSGDDSGASQPHRHLQFLPVEAMRQPGSESWHPLIDLLTSQPTSPSSTPKFQHLPGLPFAHFALPIPPNPSAETLHAIYLTLYKAAAAATRGRTPSQDTEPLPTQGPASISYNLAMTRSTMMICPRRQETALVPVDSAATRDIVDPGVLSLNGTILAATLMVKAEGEWDALRENPEHLTQVLATIGYPRTDSRGPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P582</accession>
    <name>A0A0G4P582_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromo domain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S006g000003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P582"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL21463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="48" mass="5348" checksum="C431CC7DF0F205A2" modified="2015-09-16" version="1">MPLLAEGYNAAIMITDKFTKLIGMIAGRADWDSEDWALGTLSFWPQCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P6P8</accession>
    <name>A0A0G4P6P8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S006g000540</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL22000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P6P8"/>
    <dbReference type="STRING" id="1429867.A0A0G4P6P8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF8">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="4">
        <location>
            <begin position="23"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL22000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="337" mass="36686" checksum="4E1EEF7A7C4D1246" modified="2015-09-16" version="1">MPKYAKDQAVGFKNAVERIAIVGAGGTIGSHIAAALLETGKHTVTALSRKDSSNKLPEGVLVAPVDYDDEATIVAALKDQQFLIITMAPTAPRDAHSKLVQAAAKAGVPYIMPNSYGGDIDNIKLGEETMLGPVGKAHRDEIERLGMQWITMCCGFWYDYSLAGGEARFGFDFDKRSLTLYDDGNTKNSTSTLSQVGRAVAKVLSLKEFPEDESDKSLTLSGFLQKGVYIKSFVVSQNDIFESVKRATGTTDADWTVTHEATKKRYEDGLAQVRSGNMAGFSKMLYARTFYPDDANDVSAKAQNELLGLPEENLDESTKVGIDMVKDLQSRVERMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P726</accession>
    <name>A0A0G4P726_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S007g000083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P726"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL22102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="70" mass="8124" checksum="44B459FF37112502" modified="2015-09-16" version="1">MPMATELISHISHAFTPFLPPLENWSNFPIHRGFEMAGFSFAQADPPRWSDVWILRQKRFIFDSFSANAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7N5</accession>
    <name>A0A0G4P7N5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S007g000285</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4P7N5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="47"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="269"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL22304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="549" mass="60247" checksum="31C290BDF6184769" modified="2015-09-16" version="1"> </sequence>
</entry>
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    <accession>A0A0G4P7T7</accession>
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        </submittedName>
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
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                <person name="Silar P."/>
                <person name="Lacoste S."/>
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                <person name="Bensimon A."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
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        <property type="protein sequence ID" value="CRL22370.1"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL22370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="705" mass="76991" checksum="3F1167B5339A4345" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P869</accession>
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        <submittedName>
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        <name evidence="8" type="ORF">PCAMFM013_S007g000502</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1429867.A0A0G4P869"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408:SF58">
        <property type="entry name" value="TRANSCRIPTION FACTOR (TFIIIA), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="281"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="310"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="210"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="336"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="210"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL22521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="365" mass="39844" checksum="8AF66AD30AC8952E" modified="2015-09-16" version="1">MNQNLVHPSITSPRREDIRSRETSSVYSSPISASSQGRVSPIGLGISRCEIENAFGQLRVFPPTPTLPSQLVPGAPNPTFELSYDDYSSGSCYPPVYSGLVNSASETSLGFYSPPAMSASPSYNSTMEVVPGQNVFPAQMTDIWMHTPCSGPTTPSDVTPVTVANGATGQWDQSVFPDACITSTMPLLPVNNVSYLGAMGDEIGYRSSGHSINTGQVVPQPQASEGTDGATHSSKRERGSSNDRLVSASGLECPICGAKFTRRSNCKEHQKMHNPEWKNNHPCEDCHKTFGRSSDLKRHMSTVHLGLRRYICHSCDRRFSRQDSLARHDCVEKHRNAARSTSHAEPSSLMPKQRQRVSNNRRSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P8R9</accession>
    <name>A0A0G4P8R9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">PCAMFM013_S008g000140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CRL22711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL22711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="351" mass="39960" checksum="DF24964E0402C962" modified="2015-09-16" version="1">MAKSSRRSGRGKTTPASSGASTPSSASSGPIPPFTKVPQALQPFVEELSPDEVYLVHIDISAEELKRQTFTVPLIVNLVVTAVIGLRIYMGISTYPALVATLIGLQTSMTVDTAATPWTDSVQIILRRTVTICIDYFLVTLLWSWPVNFIRGPVRWRRAIGFREREIIVRRSNRSWSKELERNRWIREDEARRDKIVAAVTPERIGKTGYLLVDEDWNLDYAAMVRAHALVDRTRKGDGVQMDEFRTAVLVNTDADGWLIWRVGDENTPTGEKRSIQRDQILAFKEKLTEMGKEDLFLRWVELIQWESSRPGGFTAERQRSAMLQAKQMFEDENVDFSQFWDDMGGMEGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P902</accession>
    <name>A0A0G4P902_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S008g000214</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793141">
        <property type="protein sequence ID" value="CRL22785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4P902"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43490">
        <property type="entry name" value="(+)-NEOMENTHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43490:SF99">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL22785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="241" mass="26181" checksum="3B0463FC9A431BE9" modified="2015-09-16" version="1">MIIALVTGANQGIGLEVTKKLAVLESHHVLMGCRDPVKGRNAAEMLQGQGLDVEFVHLDVTNDETIREAASYIEAEFGKLDILVHNAGISNDREIGNPDKSLRGLYKEQFDTNVFGAAELTDALVSLLNKSAAARVVFTSSSMASLAYCHDSIDSLYDPRFPIYRTSKAAINMLCLHYAAQYRHMGWKVNVVDPGHVATNLNRFKGPNPVESGAVQTARMATMGTDGPTGTFSRKEGGLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PA78</accession>
    <name>A0A0G4PA78_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S009g000124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PA78"/>
    <dbReference type="STRING" id="1429867.A0A0G4PA78"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052228">
        <property type="entry name" value="Sec_Metab_Biosynth_Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534">
        <property type="entry name" value="YALI0E05731P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL23184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="341" mass="36823" checksum="EA77C29369B4F0E3" modified="2015-09-16" version="1">MVSLPDVQSSNAQIANTLPAGLVAVFVGATNGIGEAALKEFARSARSPRAYFIGRSQEAAARITAECRQLNPEGEFTFIKADVSLIRNVDTVCRKIQSKENSINILFLSCGTIRCGEDTSEGLHIMSATGYYARTRFISNLLPNLKQAAGLRRVVSVLAGGHEGPIDVNDFQRKTMSMLKIRGHLVSMTDMALETLAEKAPEVTFINDYPGAVKTGIGRESNTLLTWFMTIVLMIIGPLIYIPIRESGERHLFFATSAKYPPRVRSDAAAEAGVPLSEGVEVASGTEGEIGSGVYSIHWSGEHAGPKVVKLLAGLREQGMAQKVWKHTVGEFDRIVGSADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PA99</accession>
    <name>A0A0G4PA99_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho GTPase activation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S009g000183</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PA99"/>
    <dbReference type="STRING" id="1429867.A0A0G4PA99"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04396">
        <property type="entry name" value="RhoGAP_fSAC7_BAG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051025">
        <property type="entry name" value="RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228:SF25">
        <property type="entry name" value="F-BAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228">
        <property type="entry name" value="SPERMATHECAL PHYSIOLOGY VARIANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="75"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="303"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="490"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="398"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="500"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="556"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="638"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="696"/>
            <end position="718"/>
        </location>
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        </location>
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            <begin position="797"/>
            <end position="808"/>
        </location>
    </feature>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL23243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="876" mass="95162" checksum="FD36A467C42D9EF5" modified="2015-09-16" version="1"> </sequence>
</entry>
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    <accession>A0A0G4PAG2</accession>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="20"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL23290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="93" mass="10194" checksum="F20157391828D33A" modified="2015-09-16" version="1">MSAQNSAGIQTLLDAEREAQKIVQKEYRPYPADKRRQVRGPEGDRGIQEPEGRGVQEVRGRALKRIQGSRGGGRQGSRGQAPGDQGIRQEAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAV7</accession>
    <name>A0A0G4PAV7_PENC3</name>
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        <submittedName>
            <fullName evidence="10">Beta-ketoacyl synthase</fullName>
        </submittedName>
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        <name evidence="10" type="ORF">PCAMFM013_S009g000370</name>
    </gene>
    <organism evidence="10 11">
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Silar P."/>
                <person name="Lacoste S."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
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        <text evidence="1">Secondary metabolite biosynthesis.</text>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Non-reducing polyketide synthase aptA"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030918">
        <property type="entry name" value="PT_fungal_PKS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04532">
        <property type="entry name" value="PT_fungal_PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF37">
        <property type="entry name" value="SI:DKEY-61P9.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22621">
        <property type="entry name" value="CurL-like_PKS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="8">
        <location>
            <begin position="397"/>
            <end position="832"/>
        </location>
    </feature>
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        <location>
            <begin position="1323"/>
            <end position="1634"/>
        </location>
    </feature>
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        <location>
            <begin position="1704"/>
            <end position="1778"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="5">
        <location>
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            <end position="1458"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="5">
        <location>
            <begin position="1485"/>
            <end position="1634"/>
        </location>
    </feature>
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        <location>
            <begin position="1672"/>
            <end position="1702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1682"/>
            <end position="1696"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="5">
        <location>
            <position position="1355"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="5">
        <location>
            <position position="1545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL23430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1779" mass="193224" checksum="430027B353D06237" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBE6</accession>
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        <submittedName>
            <fullName evidence="3">Cell differentiation, Rcd1-like</fullName>
        </submittedName>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
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    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT9 family.</text>
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    <dbReference type="GO" id="GO:0030014">
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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    <feature type="repeat" description="Hemopexin" evidence="1">
        <location>
            <begin position="111"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="1">
        <location>
            <begin position="164"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL24080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="219" mass="24061" checksum="5121626F7E760950" modified="2015-09-16" version="1">MVDAACRIAGKEEVYIFAGRHYGRVRFNKGGPEHGLAAGPTLLSKGWNTLPKMGFGTVDTIVPVPGQEKQLYVFYGGRYAEIKLENYDDSFVNNGASLITSGWKSLAQAGFDTVDAAMLTPGTKNEMYFFRGLHYVRLDNSTDKIVNKVAPIAEGWPSLVQAGFDRVDAIVASPSTQDHYYVFRGDQFAVIKVDSSRRDTLVSPPKAISSAWQALEGWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCQ9</accession>
    <name>A0A0G4PCQ9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Terpenoid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S011g000110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the trichodiene synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PCQ9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PCQ9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016838">
        <property type="term" value="F:carbon-oxygen lyase activity, acting on phosphates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024652">
        <property type="entry name" value="Trichodiene_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06330">
        <property type="entry name" value="TRI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL24116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="375" mass="43250" checksum="AD073677E17D3B99" modified="2015-09-16" version="1">MDFISNEELSNILVEFLDKFGYKDEDRLSHSDLQAIYDYTLPFLPDDEKIVLSLSEYVHCTFPFLPLQIRKAVAVYDSFQMSVDDVPEEKHDSLHELCIQLSERRNVQHPVWNGLFSFFPTLLQFYGPYAQTTIFRGALEFIQATCVERTLFKGFPDSNYPNYIRRMSAQGPVQAAICFPESEFPQDQYLSAIVSLEAELEYYVGTVNDVFSFYKESDTVFDRINFPLNEAICSGKPCSEILRQLVDVSIACRNRVRKMLESIGDRKLSDRAEQFFIGYVRYHLACSRYKIDSLCAVSNNARLREFYDMSLQAVGQPTKLGPKAYESPIKASYDMRSADPCDEKKEGKRGIGIAAKICAWRRFTWQKLKFRSVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PCZ6</accession>
    <name>A0A0G4PCZ6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S011g000189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PCZ6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL24195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="97" mass="11008" checksum="E123A6800EABDF2C" modified="2015-09-16" version="1">MAETSADAPPPPPPPPPPKSNKEKKKEWCAAIEKGKRQRKKARRARIEAMFNAMLDHYNAMGDENQPDAGSDAIRVLRELAEELEEERNPHTHVKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PF48</accession>
    <name>A0A0G4PF48_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Beta-galactosidase</fullName>
            <ecNumber evidence="4 13">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PCAMFM013_S013g000169</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="4 13"/>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL24926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PF48"/>
    <dbReference type="STRING" id="1429867.A0A0G4PF48"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.20.10:FF:000001">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000065">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000088">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.390.10:FF:000001">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000040">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.20.10">
        <property type="entry name" value="Beta-galactosidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.390.10">
        <property type="entry name" value="Beta-galactosidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018954">
        <property type="entry name" value="Betagal_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037110">
        <property type="entry name" value="Betagal_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025972">
        <property type="entry name" value="BetaGal_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036833">
        <property type="entry name" value="BetaGal_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025300">
        <property type="entry name" value="BetaGal_jelly_roll_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019801">
        <property type="entry name" value="Glyco_hydro_35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13364">
        <property type="entry name" value="BetaGal_ABD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10435">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13363">
        <property type="entry name" value="BetaGal_dom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SMART" id="SM01029">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117100">
        <property type="entry name" value="Beta-galactosidase LacA, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01182">
        <property type="entry name" value="GLYCOSYL_HYDROL_F35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 13 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195421" description="Beta-galactosidase" evidence="15">
        <location>
            <begin position="19"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase" evidence="16">
        <location>
            <begin position="396"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CRL24926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1008" mass="109813" checksum="BBF5FDFD2E2BBAEC" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PFC0</accession>
    <name>A0A0G4PFC0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alcohol dehydrogenase superfamily, zinc-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S013g000208</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL24965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PFC0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PFC0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08284">
        <property type="entry name" value="FDH_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF6">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="7">
        <location>
            <begin position="25"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="6">
        <location>
            <begin position="181"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL24965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="350" mass="38543" checksum="C4AFCB9E450FA5A2" modified="2015-09-16" version="1">MQAVVFKGPSKVAIEQKPIPQIQDPTDVILKVRYTALCGSELHVFRGHQKSGTEFIMGHEFTGEVVELGSDIKNFQKGDRVVSPFTSSCGECFYCERGFSSRCARSQLFGTVALDGGQAEYVRIPLADSTLAKVPASIDEKKLVLMADIFPTGYFASLNAFSGTTPEEIQKSTVLLFGCGPVGICALISALDYKPKNLIAIDSVPSRLALAQSLGAEAWNFKEDEEGLRQRVKDLTDGRGADIVIEVVGHSSALRMGFDLLRPWGRISSVGVHNQDIPWTGNEAYAKNLRLQMGRCPVRSIFGPAMDLFEKKQDVLNFMSQDIRPLSHAVQAYDDFDNMRAHKVIFEADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PFI2</accession>
    <name>A0A0G4PFI2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S013g000309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL25066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PFI2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PFI2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL25066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="56" mass="6264" checksum="83F7A3D45A378069" modified="2015-09-16" version="1">MAWAIDSLSLSKRHQRGNTMKSGRQRSNGKMHRGTRSFRSSSASKALSSLLMGKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PFQ6</accession>
    <name>A0A0G4PFQ6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Haloacid dehydrogenase/epoxide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S014g000042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PFQ6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PFQ6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01493">
        <property type="entry name" value="HAD-SF-IA-v2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF3">
        <property type="entry name" value="HALOACID DEHALOGENASE, TYPE II (AFU_ORTHOLOGUE AFUA_2G07750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL25146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="263" mass="29768" checksum="34F2BA49EF32FF37" modified="2015-09-16" version="1">MSTDNPPQMLFFDTFGTVVSWRTCVTEELIAATLQAVNHPDKDLPADLRDRAVAVTRDDWLAFVAEWRHSYSVFTETFDPSSEFVSVDQHHYNALQDLLQKRGLDGLFTDEKLWELAFAWHRLNPWSDSAQGIELLNRQFATSTLSNGNVSLLQDLQRHGSLPFTHLVSAENFTAYKPSPLVYNGAAKMFGLEPGQCALIAAHLRDLKAAKSCGFQTIYVEREQEEEMSSEQAAEAKTEGWVDMWVDLESDGFREVAKRFGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PG04</accession>
    <name>A0A0G4PG04_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized conserved protein UCP033271</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S014g000086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793147">
        <property type="protein sequence ID" value="CRL25190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PG04"/>
    <dbReference type="STRING" id="1429867.A0A0G4PG04"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15488">
        <property type="entry name" value="Tm-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12030">
        <property type="entry name" value="Uncharacterised protein family UPF0261, NC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12020">
        <property type="entry name" value="Uncharacterised protein family UPF0261, NN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051353">
        <property type="entry name" value="Tobamovirus_resist_UPF0261"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008322">
        <property type="entry name" value="UPF0261"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056778">
        <property type="entry name" value="UPF0261_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044122">
        <property type="entry name" value="UPF0261_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002674">
        <property type="entry name" value="PRK02399.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31862">
        <property type="entry name" value="UPF0261 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G10120)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31862:SF1">
        <property type="entry name" value="UPF0261 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G10120)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06792">
        <property type="entry name" value="UPF0261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23189">
        <property type="entry name" value="UPF0261_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033271">
        <property type="entry name" value="UCP033271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0261" evidence="1">
        <location>
            <begin position="2"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="UPF0261" evidence="2">
        <location>
            <begin position="204"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL25190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="435" mass="46963" checksum="6F6C58BF091B1C07" modified="2015-09-16" version="1">MPHIILLGTLDTKLAETLYLYNQLQQNATRFATPLEITLIDCGRQVITHDAITINHTDLLSKYASGDNTEILTQSRGQVIELLISCVSKCVAELLQTTEIHGIIGAGGSGGTSLITAVMRKAAPLGLPKLVVSTVASGDTGPVIGECDITLMYSVVDIAGTNRLLREVLGNAAGAMIGMASTYQHRQAERRTQTAQDKQREEKKTRVGITMFGVTTPCVDRVRSHLEDNYSVEVYVFHATGHGGKAMERLVEEGRLDAILDITTTEICDLIAGGTMSCENSRLERTLKRGIPNIISVGATDMVNFGPADTVPPQYRDRKLLVHNPTITLMRTSAAECREVGEFILDKLNRFTQEPSMVEVWLPRGGVSSVGTEGSAFADADADAALAETLRSGLKDSGIRVVSDERDINDDGFTLDIADRLMALVAKHSCSATTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PH43</accession>
    <name>A0A0G4PH43_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome c oxidase assembly protein PET191, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S015g000252</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PET191 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793148">
        <property type="protein sequence ID" value="CRL25666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PH43"/>
    <dbReference type="STRING" id="1429867.A0A0G4PH43"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018793">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_Pet191"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10203">
        <property type="entry name" value="Pet191_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL25666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="119" mass="13266" checksum="CCB199062DC9C4E9" modified="2015-09-16" version="1">MPSSCNDIRKALAQCLQESDCIMVQRHSPRECLSSPLAEELPTKCQQLRKGFSECKRGMIDMRKRFRGNQPISVSKEMDDGKPSNSSGGQLYAGQPAYQSVKEISGNEVQMDPEKTRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PHJ0</accession>
    <name>A0A0G4PHJ0_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nitrate reductase [NADPH]</fullName>
            <ecNumber evidence="8">1.7.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">PCAMFM013_S015g000271</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>nitrite + NADP(+) + H2O = nitrate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19061"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion outer membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the nitrate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.3" evidence="8"/>
    <dbReference type="EMBL" id="HG793148">
        <property type="protein sequence ID" value="CRL25685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PHJ0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PHJ0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050464">
        <property type="term" value="F:nitrate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000019">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF7">
        <property type="entry name" value="SULFITE OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0274">FAD</keyword>
    <keyword evidence="11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="10" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="18" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="22">
        <location>
            <begin position="657"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="23">
        <location>
            <begin position="768"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="133"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="134"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00015499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CRL25685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1029" mass="118032" checksum="8BC742939DF07154" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PI01</accession>
    <name>A0A0G4PI01_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Indoleamine 2,3-dioxygenase</fullName>
            <ecNumber evidence="5">1.13.11.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S016g000109</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Produces N-formyl-kynurenine through the oxidation of tryptophan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-tryptophan + O2 = N-formyl-L-kynurenine</text>
            <dbReference type="Rhea" id="RHEA:24536"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.52" evidence="5"/>
    <dbReference type="EMBL" id="HG793149">
        <property type="protein sequence ID" value="CRL25828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PI01"/>
    <dbReference type="STRING" id="1429867.A0A0G4PI01"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF5">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2 5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195362" description="Indoleamine 2,3-dioxygenase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="7">
        <location>
            <begin position="440"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL25828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="699" mass="77552" checksum="BD15C2D0151B8BD0" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PIB2</accession>
    <name>A0A0G4PIB2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase T2, asparaginase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S016g000212</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793149">
        <property type="protein sequence ID" value="CRL25931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PIB2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PIB2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04514">
        <property type="entry name" value="Taspase1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.30:FF:000007">
        <property type="entry name" value="Similar to threonine aspartase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.30">
        <property type="entry name" value="(Glycosyl)asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037464">
        <property type="entry name" value="Taspase1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188:SF8">
        <property type="entry name" value="THREONINE ASPARTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="203"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="2">
        <location>
            <begin position="285"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL25931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="556" mass="59852" checksum="6C095C4700D2665B" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJ79</accession>
    <name>A0A0G4PJ79_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Adrenodoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S018g000145</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the adrenodoxin/putidaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJ79"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJ79"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <source>
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</entry>
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    <accession>A0A0G4PJC6</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="700" mass="76296" checksum="F0E80647DD45F9A4" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJE9</accession>
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        </submittedName>
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    </gene>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL26532.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="852" mass="92994" checksum="A50F03E22190BDB5" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJK2</accession>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
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        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
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            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="88" mass="9360" checksum="FCA9DC9B7FC37722" modified="2015-09-16" version="1">MKPVVSALNAWSCVVISVFAIVILSVLGSLYSSNNHAYTGSKDEPEDGPAVAASIYTAVIVYAGFFVFCGFQAYLHMRDSRGGAISLH</sequence>
</entry>
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    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Lacoste S."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="807" mass="90905" checksum="BC51471EB367C07A" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKF5</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
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                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
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                <person name="Lacoste S."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="CRL26686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="141" mass="15632" checksum="B36282C146754169" modified="2015-09-16" version="1">MEIKGIATANLSWDLSKGPMPHKLQNKVVDHCLLELLGYGNGANHAILRLVFKNPQVQASPWGPANVQGVTMELEVQDEARLGTVEGQLVVKTFRFTGPHRRACISYKLLVQGHRTVSDFMNVANKANLTPCDFYSVAVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PL55</accession>
    <name>A0A0G4PL55_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of G protein signalling superfamily</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">PCAMFM013_S021g000077</name>
    </gene>
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        <lineage>
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            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF267">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G06860)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="63"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="356"/>
        </location>
    </feature>
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        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL27162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="356" mass="38914" checksum="233E640A1EE8352F" modified="2015-09-16" version="1">MLKKKTLAPSLFFRNHTPTATPELSPTSSDSDSEEDMESSGSRPVSLAISSGAFSMRPTLNEVLANIAPPPYTLSAFMAYLSQNHCLETLEFTMEANRYRDSYYALAERIGPAAMESECPETQHLRMLWKRLLTAYIFPGSPREINLSSEVRDALLQYKNVPAPPVPETLDSAVKRIHDLMEESIFLPFVNSHTTSPSMGPSDPFMGPDDFMSLSSTSLDEHPMKKVRSRVSKRISPQSSSKDLSATGHNRSTMSLGAVHALGKRTSGALVNTSGESAYLSLTDDSASPQSSPTAEEPMTPPTTPPASEPHLPIHSPRLRTENPWKKMGMKLGFKKRSTGGSNGSSRDPKILGLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PM01</accession>
    <name>A0A0G4PM01_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Anaphase-promoting complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S022g000122</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RING-box family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793155">
        <property type="protein sequence ID" value="CRL27442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PM01"/>
    <dbReference type="STRING" id="1429867.A0A0G4PM01"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16456">
        <property type="entry name" value="RING-H2_APC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000111">
        <property type="entry name" value="Anaphase-promoting complex subunit 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024991">
        <property type="entry name" value="RING-H2_APC11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12861">
        <property type="entry name" value="zf-ANAPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="35"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CRL27442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="87" mass="10106" checksum="3A4829B364EBAFB2" modified="2015-09-16" version="1">MKVAIKEWNAVATWHWNIPEDEVCGICRVQFDGTCPTCKFPGDDCALVQGRCNHAFHMHCLMTWIDLESSKGLCPMCRQKFEWKDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PM06</accession>
    <name>A0A0G4PM06_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Rhodopsin, bacterial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S022g000130</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal/bacterial/fungal opsin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793155">
        <property type="protein sequence ID" value="CRL27450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PM06"/>
    <dbReference type="STRING" id="1429867.A0A0G4PM06"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15028">
        <property type="entry name" value="7tm_Opsin-1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000160">
        <property type="entry name" value="Related to Opsin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001425">
        <property type="entry name" value="Arc/bac/fun_rhodopsins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286:SF2">
        <property type="entry name" value="BACTERIORHODOPSIN _OPSIN, NOPA (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01036">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00251">
        <property type="entry name" value="BACTRLOPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01021">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL27450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="302" mass="32856" checksum="A10C1639A9692D7D" modified="2015-09-16" version="1">MIQPPFDQFATLTAPATTSSVAPIPTVIPGSEVYQELHDVGKRTLWVVTVLMGISSLVFYALAARAPLSKRIFHILTSLITTISFIIYLALSTGQGITTKHNRVHESHKHVPDTHTDYIRQVLWLRYVNWALTTPLLFINFALLSGLPGANLLIAIVAHLVMLATALFGIFAGHGRERWVWLTLTCISYLVVIHHVGFHAQKAAKGKDAQTQRFFGSISGSAIAMLALFPISLAAGALALKLSVDTETILFAIQDVFTQGVLGYWLLLAHESASGIALHIEGFWSHGVGNEGAIRISDEEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMH9</accession>
    <name>A0A0G4PMH9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Dihydroxyacetone kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S023g000105</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13941"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15773"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; glycerol fermentation; glycerone phosphate from glycerol (oxidative route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dihydroxyacetone kinase (DAK) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793156">
        <property type="protein sequence ID" value="CRL27647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PMH9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PMH9"/>
    <dbReference type="UniPathway" id="UPA00617">
        <property type="reaction ID" value="UER00669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050354">
        <property type="term" value="F:triokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019588">
        <property type="term" value="P:anaerobic glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10440:FF:000002">
        <property type="entry name" value="Dihydroxyacetone kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.340:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1180.20:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10440">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.20">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012734">
        <property type="entry name" value="DhaK_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050861">
        <property type="entry name" value="Dihydroxyacetone_Kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02361">
        <property type="entry name" value="dak_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629:SF14">
        <property type="entry name" value="DIHYDROXYACETONE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629">
        <property type="entry name" value="TRIOKINASE/FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82549">
        <property type="entry name" value="DAK1/DegV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="DhaL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="14">
        <location>
            <begin position="9"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="DhaL" evidence="13">
        <location>
            <begin position="386"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-hemiaminal-histidine intermediate" evidence="11">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="57"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CRL27647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="591" mass="62598" checksum="6DFBC99342DE0373" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNF5</accession>
    <name>A0A0G4PNF5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribonuclease H</fullName>
            <ecNumber evidence="4">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S024g000154</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="4"/>
    <dbReference type="EMBL" id="HG793157">
        <property type="protein sequence ID" value="CRL27899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PNF5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PNF5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09280">
        <property type="entry name" value="RNase_HI_eukaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000090">
        <property type="entry name" value="Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.970.10:FF:000001">
        <property type="entry name" value="Ribonuclease H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="entry name" value="Ribonuclease H1, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="12" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="RNase H type-1" evidence="11">
        <location>
            <begin position="220"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="140"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL27899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="395" mass="43182" checksum="8F5CF2FBE6DA342F" modified="2015-09-16" version="1">MNKTTPSPSPVPKASPSSKPSPSPTAGTKRKRNAPAKYYAVKAGHKPGIYYGWNDCLAQITGFKGAIFQSFPSQEAANAFLNGTKPPAESQSSENTRFYGIQRGRVTGVYTDWTTAQEQIRGFPRPRYRKFSTREEAEEFVREGQTQPPAGFGVASGPHGITTEKPKDAEGVEFAPGDGPLPAGAEDGFDPNVLLDPATGKVVYKTAPQMAATKTQSTGIPGMLRIYTDGSSLRNGTPLASAGVGVYFGPGDSRNVSEPLKGSRQTNQRAELTAILRAIDIAPRHRDVTIITDSRYSIDCVTVWFVNWRRNNWMTRDKKPVENKDLVESILIKIEERNDLKVKTLFEWVKGHNKDPGNEEADKLAVNGAQRGVSAKAEALHVAQEVPDELFDDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNF9</accession>
    <name>A0A0G4PNF9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DSBA oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S024g000159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793157">
        <property type="protein sequence ID" value="CRL27904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PNF9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PNF9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03024">
        <property type="entry name" value="DsbA_FrnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887:SF41">
        <property type="entry name" value="THIOREDOXIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="1">
        <location>
            <begin position="6"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL27904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="232" mass="25913" checksum="58BFA4EDC98E2609" modified="2015-09-16" version="1">MTNFQIQIISDTVCPWCYVGYRRLSRAITTHQATYPADTFSLHWKAFYLNPASAEYPGVNKAEMYTRKFGAERFEAIFARLSAVGKSEGIQFSFGGNTGLTRDSHRLLWFAGQREAEEVAKKEGADGVIGGLQTRVAEQLFRAYFEEEKNITDLKVLVEAGVGAGLDRETVKKLLDEDVGAEEVDLEAKTAARRLVSGVPYISVQGKYHVEGADEPEVFIDIFEKVKAEQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNX9</accession>
    <name>A0A0G4PNX9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sugar/inositol transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S026g000042</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793159">
        <property type="protein sequence ID" value="CRL28177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PNX9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF7">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="462"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="10"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL28177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="549" mass="60126" checksum="ED7A98AC978CE215" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PP09</accession>
    <name>A0A0G4PP09_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GTP-binding protein ypt1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S024g000183</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Preautophagosomal structure membrane</location>
            <topology evidence="8">Lipid-anchor</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793157">
        <property type="protein sequence ID" value="CRL27928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PP09"/>
    <dbReference type="SMR" id="A0A0G4PP09"/>
    <dbReference type="STRING" id="1429867.A0A0G4PP09"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01869">
        <property type="entry name" value="Rab1_Ypt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000069">
        <property type="entry name" value="Ras GTP-binding protein YPT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057289">
        <property type="entry name" value="Rab1/Ypt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="188"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL27928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="201" mass="22303" checksum="8DC1A5B0BEBDF378" modified="2015-09-16" version="1">MNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTVKLQIWDTAGQERFRTITSSYYRGAHGICVVYDVTDMDSFNNVKQWLQEIDRYATEGVNKLLVGNKSDMEDKKVVEYTVAKEFADSLGIPFLETSAKNASNVEQAFLTMARQIKERMGTATVNNKPTVQVGQGQGVQSGSAGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PP25</accession>
    <name>A0A0G4PP25_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S025g000001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793158">
        <property type="protein sequence ID" value="CRL27943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PP25"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL27943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="139" mass="14875" checksum="BA7A13D312DCB365" modified="2015-09-16" version="1">MRNPTKLDKDLLRRQDNSFVWACFVSFVLACLGGFCFPLHFFGDIDQLVVTMSFLAVNPLAGPSPDPLAAPDENLEGNTMDLRSLSASSPLSAPQDSPDMETSSAGASQPSTDPSPSPRFVNLNAKDATEWPTSLGDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPM5</accession>
    <name>A0A0G4PPM5_PENC3</name>
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        <submittedName>
            <fullName evidence="9">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S027g000046</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PPM5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="6"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="58"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="382"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="743"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="743"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="800"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="827"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL28357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="947" mass="104013" checksum="89F45BA73A1D5C14" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PR02</accession>
    <name>A0A0G4PR02_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S029g000019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793162">
        <property type="protein sequence ID" value="CRL28603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PR02"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL28603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="47" mass="5720" checksum="7D4C5097EC286895" modified="2015-09-16" version="1">MIGDLLLWHLLREISKISHFLRFPSRIALFPSQYDIHHEMFQILPMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PSD5</accession>
    <name>A0A0G4PSD5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cation efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S032g000062</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
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        <property type="protein sequence ID" value="CRL29026.1"/>
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    <dbReference type="STRING" id="1429867.A0A0G4PSD5"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000013">
        <property type="entry name" value="Cation efflux family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000010">
        <property type="entry name" value="Cation efflux family protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF15">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="9">
        <location>
            <begin position="39"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL29026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="372" mass="40228" checksum="19A2EE1578A01ED8" modified="2015-09-16" version="1">MTQTRDHGHSHGHGHHHHHDNTYLTSTNKHDAGVRITRIGLVANLCMAIGKFIGGYMFHSQSLIADAYHALTDLVSDFLTLGTVAWSLKPPSERFPNGYGKIESIGALGVSGLLLCGGVFMGLNAGQVLLAQFYPDVAETVAHSGILGHGHSHSHGPIGPSIHAAWIAAGSIVVKEWLYRATMKVAEERKSSVLASNAIHHRIDSLTSIVALFTIGGSYVFQDATWLDPVGGVLISLMVIKAGWGNTCTSLLELADTTVDEEVRHSVEDAASKALKDIEDGHEVIVRDVQGMKSGQNYLMDIELAVPGAWAISRSRHIEEAVRQAVGSGVRGVKRIKVRFIPVEDQHLTFSDEFVAQDVSGDPETPHARKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PSU0</accession>
    <name>A0A0G4PSU0_PENC3</name>
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        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S036g000026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793169">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PSU0"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Glyoxalase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40265">
        <property type="entry name" value="BLL2707 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40265:SF1">
        <property type="entry name" value="GLYOXALASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13468">
        <property type="entry name" value="Glyoxalase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL29442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="260" mass="28432" checksum="20778B2F764C138C" modified="2015-09-16" version="1">MPEQQTPILDHIVLLVSHKTLLGISEHIEGQFTLAPGGTHADGLTTNKLILLPDGVYLEIIAFFDDIDPEKRRNHRWGNEKEDTIVDWAFTLRSENDFSAVQQRFQGADTNASYTDPIAGGRTKPDGTVLKWAVCVPKDGQGKVVPGSLPFWCLDRTPRANRVPYEVEPHLAQHPNGVQGISSVSVQVPDGEISNFKGAYDAIFGGPWKYEVPSGSTAGKHGVSLSGGDASIRLVFNGLKEGKVEFLPGLFFDIERLDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PSU2</accession>
    <name>A0A0G4PSU2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S034g000031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793167">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PSU2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL29233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="290" mass="31457" checksum="7641485AD47088E5" modified="2015-09-16" version="1">MGTATDLPSLSNRSHPLDGLPPPYTEHDPQSAAQAPQYEIPSHTACGSTSTPATAKFPPAMNGYFQWKLTTTFHLGPTADKKLYAVSTPANVFNNKPTIVLHDGPTNKHPVMATAQSDRWGRSRPIAITLPPRPGSQHQGSIVEQIPGGPLKHFSPSHMFEISVGPKGTSRERFEWRKSHGNEIKKLVGFSYGWKLVRLTGPVNNVAESRKERALGYTSDGLEIVALIAHNASWSMTKGFRFAFMGAGLTGTMGENWEIVVVISALQLWFIDVQGISDTAAATDVATSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PT28</accession>
    <name>A0A0G4PT28_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S034g000086</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793167">
        <property type="protein sequence ID" value="CRL29288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PT28"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF41">
        <property type="entry name" value="MFS TRANSPORTER OF UNKOWN SPECIFICITY (AFU_ORTHOLOGUE AFUA_5G09940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="572"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="138"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL29288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="603" mass="64992" checksum="722D33BC6C1605AD" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PT82</accession>
    <name>A0A0G4PT82_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S038g000003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Dupont J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
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    </evidence>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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    </evidence>
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</entry>
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            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793174">
        <property type="protein sequence ID" value="CRL29913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PU45"/>
    <dbReference type="STRING" id="1429867.A0A0G4PU45"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL29913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="97" mass="11108" checksum="E635ADA64B2569F7" modified="2015-09-16" version="1">MLWFPEWWVKTRSPAYPMQTWPALDVSRAFWLCFVTLDRAYFQTGTLPEVGTLCQADLKPLVGSPLHPTSQNFSAADRRLFDALMAEVHRGPLIPML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUB6</accession>
    <name>A0A0G4PUB6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="5 7">2.5.1.75</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S044g000031</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = N(6)-dimethylallyladenosine(37) in tRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 8">Belongs to the IPP transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="5 7"/>
    <dbReference type="EMBL" id="HG793177">
        <property type="protein sequence ID" value="CRL30100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PUB6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PUB6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.140:FF:000003">
        <property type="entry name" value="tRNA dimethylallyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030666">
        <property type="entry name" value="IPP_transferase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088:SF89">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01715">
        <property type="entry name" value="IPPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039110">
        <property type="entry name" value="IPP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="437"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="437"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="451"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR039110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL30100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="476" mass="54448" checksum="FD5214BCCCF4A295" modified="2015-09-16" version="1">MLSALRSIWHGQRRMNPLIAVVGATGTGKSKLAVDLASRFNGEIINGDAMQMYRGLPIITNQIPTEERKGIPHHLLSCIDLDAEAWRIGLFKREALRVIEEIRARGKVPILVGGTHYYTQAVLFKEQLVGEGVDDEGEREQLTEFSSTSKKWPILDSSPEILLEKLREVDPVMAARWHPKDARKIRRSLEIYFQTGRKASEIYKEQFSQKRKAIDQEEGLLRFENTLVFWVHAEKEVLNARLDARVDDMVKQGLMTEAEKMSDYLQEKASQGIEVDQTRGVWVSIGFKELAPCFKAIRDGEASEKEIEDLKRNSLELIRIATRQYGTSQVKWIRNKLWQALTEAGETRRLYLLDSSNVSDWNKCITEPSEEIVQLMQQNKPTPEPKSLSQLATTEFGAKEAQAQKRVQTDPIGKCYTCDVCQKTMASEDQWHIHLNSHQHKRGLKSASRRAQRDEYFRKKELEAQGIQPTETEPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUL2</accession>
    <name>A0A0G4PUL2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S043g000016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793176">
        <property type="protein sequence ID" value="CRL30021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PUL2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="166" mass="19167" checksum="4D8EB49781EEFE98" modified="2015-09-16" version="1">MELHLLSISAPHLDVNPHHLRESDGGQHETKTNQTSPPQQSEDFTGLLKSPYLPRLCDLENIASVLIVRQESPWDTYRKVITYEIAGKVTIATRRTRLSRMVAIQTYRKENARRLMYRFGRLEHRHVLSLHKCYMHEDLALFLVDDLPLTLTHVVAFLSKLNSVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PUU6</accession>
    <name>A0A0G4PUU6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mRNA stability protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S048g000007</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the endosulfine family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793181">
        <property type="protein sequence ID" value="CRL30295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PUU6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PUU6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006760">
        <property type="entry name" value="Endosulphine"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04667">
        <property type="entry name" value="Endosulfine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="64"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL30295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="132" mass="14631" checksum="ADC59C0E4F10BBE9" modified="2015-09-16" version="1">MQSGSKGPDPELLSESDKRNVRKYGKLPRGGLLAQQSKERTYFDSGDFALSAADRMTDNGVIKTGRAHPHRDSISHPYAPIPAASNVDKDATEDLYRKSVDPEKSPLLQKENIQDEEPTNEEEHDNPISLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PV67</accession>
    <name>A0A0G4PV67_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclin-like F-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S048g000030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793181">
        <property type="protein sequence ID" value="CRL30318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PV67"/>
    <dbReference type="STRING" id="1429867.A0A0G4PV67"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="4"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="270" mass="30639" checksum="36360437156189CC" modified="2015-09-16" version="1">MSSSPTLESLPFDILFQIAVYLDVRDYIHISHSSRSMFSSMKNTIIARATVKNTMLYSNEGQAAWAGKVGHYQAIQHRFDIHEAVATASPYSVSVLAYATDFLYHQGFLCYRFKNQIRLLNVHDAGQKERVLDLDHVIRRIIGIENILSDVGEQTTLLRFSSGILILLVNQTNSNEGILIAVDLQSHPGQARRRRLLLQEPVSSSDPIFVRHTRLYIWCGTFTPANGQGIAWQVWGMDFRTLCCDMRLVQIRNQAAPSELAPKCLYRRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVD9</accession>
    <name>A0A0G4PVD9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidase A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S052g000012</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793185">
        <property type="protein sequence ID" value="CRL30455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PVD9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PVD9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF30">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="6">
        <location>
            <begin position="29"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL30455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="539" mass="57479" checksum="6E698219B5F4A116" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVN5</accession>
    <name>A0A0G4PVN5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S046g000021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793179">
        <property type="protein sequence ID" value="CRL30217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PVN5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195999" evidence="2">
        <location>
            <begin position="17"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL30217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="302" mass="30818" checksum="4189C2D84831FB96" modified="2015-09-16" version="1">MTLRLFFLALASTVNAYLQASQFAEDTCSTLNRWEVASNMTSSAQYLLGSHERSFLLSENCADHLETAVMNCMDGSKFLCSEFSISVINTKNTAKGSRSVALAKKSQSDQTSSAESGCTCSTPNGVVASSSTSADGFSAIIASSVNAVVSSMSTSEGTTSSVPIETSTVPQSSATSSSSATATSPSMSTSEGTTSLVSIVSSTVVESSVITSSSATAVPSSMSTSEASSQLSPSGSLVTPQLPTSAKVRLTTTTATVISSGGTSSTTASICIIKTADLQKGLCYCLDNQVISRTDVDCQPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PW86</accession>
    <name>A0A0G4PW86_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="8">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S056g000032</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="8"/>
    <dbReference type="EMBL" id="HG793189">
        <property type="protein sequence ID" value="CRL30659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PW86"/>
    <dbReference type="STRING" id="1429867.A0A0G4PW86"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000005">
        <property type="entry name" value="Phospho-2-dehydro-3-deoxyheptonate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DAHP_synth_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009395">
        <property type="entry name" value="PRK12755.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE DAHP SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225:SF12">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, TYROSINE-INHIBITED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
        <property type="entry name" value="DAHP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP synthetase I/KDSA" evidence="9">
        <location>
            <begin position="43"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL30659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="378" mass="40954" checksum="2A09A29C562C3FFC" modified="2015-09-16" version="1">MTSSSQEDTRISGFEPLLSPEYIQHEIPASAVSLATVSTGRQQVIDILERRDDRLLVVVGPCSIHNPQEALEFASRLRELSEKLSTDLCIVMRAYLEKPRTTVGWKGLVNDPDIDESYDINKGLRISRQLYSDLTNMGLPIASEMLDTISPQYLADFISFGAIGARTTESQLHRELASGLSFPIGYKNGTSGNVNVAIDAIAAASKPHTFLGVTKEGMAAVTRTAGNEHGLVILRGGSHGPNYAKEHVSSAKQALKQKKQRENLLIDCSHANSAKNFRNQSVVAMDVASQMVSGESAIVGVMIESNLNEGNQKVPPEGPSGLRPGISITDACISWETTVEVLQNLANAVRSRREYVQSLLDCTSKSAWLETQSAGIMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PY86</accession>
    <name>A0A0G4PY86_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sulfite efflux pump SSU1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S076g000012</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Sulphite efflux pump required for the secretion of sulphite as a reducing agent. In the presence of sulphite, cystine in keratin is directly cleaved to cysteine and S-sulphocysteine, and thereby, reduced proteins become accessible to hydrolysis by a variety of secreted endo- and exoproteases. Excretion of sulphite mediated by an efflux pump also represents a detoxification pathway for dermatophytes during infection of the epidermal stratum corneum, hair and nails, which are rich in cysteine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793208">
        <property type="protein sequence ID" value="CRL31119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PY86"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000319">
        <property type="term" value="F:sulfite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09318">
        <property type="entry name" value="TDT_SSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.150:FF:000004">
        <property type="entry name" value="Malic acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051629">
        <property type="entry name" value="Sulfite_efflux_TDT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686:SF1">
        <property type="entry name" value="SULFITE EFFLUX PUMP SSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="324"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="383"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL31119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="442" mass="49228" checksum="E097BB4AF446ED6E" modified="2015-09-16" version="1">MSPRDNQNEVLSGGNEANINAATGPPERENADYYTNRSKHNGDWRHLVRNFTPAWFSVNMGTGITSILLNTLPYNGKWLYWISVVIFCLNILLFVIFFTITILRYVLYPKIFYLMVTHPTQSLFLGTLPMGFATIINMICYVCVPVWGDWAVYFAWALWIADVVVSIMTCFGIPFIVYGHANPFLEGTIKTDSHFRMTRTADSKLQAMGAAWLLPIVSCVVAAASGGIVADLLPDPQYAIGTIIVSYVLWGIGVPLAMMVIVIYLMRLMLYKLPQKAVIVSTFLPLGPLGQGGFGIQKLGAAAQKVFPLTGTLRPGSGDTLYDIGFLTGLLLWSFGCIWLFFAVAAIIRLKKFPFNLGWWAFTFPLGVFTTCTNQLGQEMPSRFFRVLGTILSVCVLLLWIVVSLFTLKGIFNRSLFVAPCLGDLQEYEPKRSQKAKHGSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PYB0</accession>
    <name>A0A0G4PYB0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S133g000001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793264">
        <property type="protein sequence ID" value="CRL31358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PYB0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL31358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="450" mass="50103" checksum="2028898765AE1345" modified="2015-09-16" version="1">MQGSRKNILIRYSALEVGLGKHRERETACKTDFEYYCTISQSSSQTIGPTSATKTSNREWQDTAISGSNISVGLSKKGVALLISIVLGGILVLIGIFTIHRFILRRLHKHTGGSATVRSQPAGSLPLQSDFGIRNPDLGLNLVKKNLVSSLGYFPVVQVCLSMDFQLNENGRSKYGEGRHRQPIVSTKFTAQMKAHGICANPATDPKNHLFKQSLGTALQEKKPPNNRNQGSDESYISYMILLFLVFSSTSPVNRITAVTNELERPVGTLLATMPRVHRPRLNLAFASITSVSGLLAQAQRTQVSQGNKGNDKITLPLKKTRLPLVNLVDTSQIMTKIQLLKRRSWPKLKRLSQAVHRNSRRILLLRAHLSALQPQLEERTSARSASMKTALCKQEQTQAQLAPGRMYLLGYFLIQHFLKRYNEGRVGNDLVDMPDLAALLIDQFHCLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PZF0</accession>
    <name>A0A0G4PZF0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cystinosin/ERS1p repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S4Jg000067</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793313">
        <property type="protein sequence ID" value="CRL31545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PZF0"/>
    <dbReference type="STRING" id="1429867.A0A0G4PZF0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015184">
        <property type="term" value="F:L-cystine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005282">
        <property type="entry name" value="LC_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131:SF5">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL31545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="272" mass="30617" checksum="66D389FE6B61A9FC" modified="2015-09-16" version="1">MLNDTWTHTVSQILGWTYFILWSLSFYPQVLHNHRRRSMDGFSVDFAVLNILGLTAYTISNACFLFSPVVRAQYAQRHPQGAEPTVQWNDFVYALHGALVCCLIGSHFLYARFWNFQSKSQRVSILAFVVIWACVGVVALAILYVWVSASWEWIDVVYVVGMIKVFLTAVKYTPQAAMNYLRQSTAGLSIVAILLDLTGAALSLMQLVLDSSLQADWSGTTGNIAKLLLGNITVLFDLIFIFQHFVLYQEQPAERKPGLSEHDPLLDSSDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NSX5</accession>
    <name>A0A0G4NSX5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Histone deacetylase</fullName>
            <ecNumber evidence="2 9">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S001g000112</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2 9"/>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NSX5"/>
    <dbReference type="STRING" id="1429867.A0A0G4NSX5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000007">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF36">
        <property type="entry name" value="HISTONE DEACETYLASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="14">
        <location>
            <begin position="58"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="477"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CRL17152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="505" mass="55795" checksum="AC426C12A7B46EFF" modified="2015-09-16" version="1">MARSSVVQEYASPSAPTLTIDHKSTAELQNLQIARPKGYRVSWHANPAVEPHHFGQSHPMKPWRLTLTKQLVMAYGMHHAMDLYLARAATYEEMADFHERDYLDFLQQIMPGDIDKPEQSDNVVRFNFGDDCPIFDGLYSYCSLYAGGTVDAARKLCNDQSDIAINWSGGLHHAKKAEASGFCYVNDIVLGTLQLLRHHPRVMYIDIDVHHGDGVEQAFWSTDRVLTVSFHKYDKDNFFPGTGAREDTGPAHPLNPGAHHAINVPLNDGIDDESYIALFKEVIGACMKTYQPGAIVLQCGADSLGCDRLGCFNLNVRAHGACVAYTKTFGMPLLVVGGGGYTPRNVSRAWAHETSILVEADNIIDPTIPDSVAFRNHFGPDFSLFPPLSEMRKLDNKNTRAYLEGLVEAVHEQLRYIKGAPSVQMSFIPPDILGLREDTEKEIEEQTMLVEEEREEYEGGGSMASAASAAAGSGLAYTGSAGAIPRPNRRRDLERGAGYRGELYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NT51</accession>
    <name>A0A0G4NT51_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Splicing factor Cactin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S001g000201</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CACTIN family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NT51"/>
    <dbReference type="STRING" id="1429867.A0A0G4NT51"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019134">
        <property type="entry name" value="Cactin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018816">
        <property type="entry name" value="Cactin_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737">
        <property type="entry name" value="POLYGLUTAMINE BINDING PROTEIN 1/MARVEL MEMBRANE-ASSOCIATING DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737:SF4">
        <property type="entry name" value="SPLICING FACTOR CACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10312">
        <property type="entry name" value="Cactin_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09732">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Splicing factor cactin central" evidence="5">
        <location>
            <begin position="70"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Splicing factor Cactin C-terminal" evidence="4">
        <location>
            <begin position="416"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL17241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="553" mass="64524" checksum="3AA7E90A05572E48" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NT80</accession>
    <name>A0A0G4NT80_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bax inhibitor-1-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S001g000218</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NT80"/>
    <dbReference type="STRING" id="1429867.A0A0G4NT80"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF112">
        <property type="entry name" value="GROWTH HORMONE-INDUCIBLE TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL17258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="336" mass="37075" checksum="6029816A3EB2B8C6" modified="2015-09-16" version="1">MAFFLRRPFAVSSALRQVPKLTNTARFIHNSPIKPTQATKPQGVSSSIFAKSRQNFQNAFRRTYMQQSFNPAQSGNMTQKLLYGAAIVGGTVLATNFIFNRETREDGGMPAYERSFLNETFMHTGLGIGIIGVAARALHMSGWSYRLMAMNPWLVMGVGLVGSIGSMYGTFYTSPDNYVMKYGCWTVFNLTQAALLSPLMFMNPAILARAGLYTVGMMGSIAFVGATAKQEKYLYLGGPLLAGVTIVALSGLAPMVLPATAVRTLMWSERLWLYGGLAVFGGFTLYDVQKILHHARLAERGLIKRDVVNECVSLELDFINIFIRMVQILGMGNNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NTE6</accession>
    <name>A0A0G4NTE6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Negative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S001g000335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NTE6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007396">
        <property type="entry name" value="TR_PAI2-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35802">
        <property type="entry name" value="PROTEASE SYNTHASE AND SPORULATION PROTEIN PAI 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35802:SF1">
        <property type="entry name" value="PROTEASE SYNTHASE AND SPORULATION PROTEIN PAI 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04299">
        <property type="entry name" value="FMN_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010372">
        <property type="entry name" value="PaiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL17375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="259" mass="28693" checksum="42D528DE7DB83516" modified="2015-09-16" version="1">MYLRAVHAEGQLPVLQQFIRDNPLGILTTAIKSPIYSFIQSSHIPFVLDVPPSTENDDTIPTGILRGHMAKQNPQAKALMEALAEQNAAGNNKLELTDEVLILFNGPHHHYVTPKFYTETKPVSGKVVPTWNYSAVQAYGKISVYCNSKAEETGAFLQKQIQDLSRQSEEGIMGYTGGDKKTAWNVSDAPANYVELLKKNIIGIEIRVERLQGKFKMSQEMGEGDREGVVKGFEELGSDVGRGIADCVKERSALKDQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NTE9</accession>
    <name>A0A0G4NTE9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S001g000332</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NTE9"/>
    <dbReference type="STRING" id="1429867.A0A0G4NTE9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000245">
        <property type="entry name" value="Short chain dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL17372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="286" mass="30977" checksum="82CA09933C8DB496" modified="2015-09-16" version="1">MSVSIETTTVPAAPMTGQPVLMGHKSRMPEFSLTGKVVLVSGAARGLGLVQAEALLEAGAKVYALDRLEEPAPEFEQIQQRAKELGTALHYRRIDVRDTELLNSVIETIANEEGRMDGLVAAAGIQQETPALEYSAKDSNTMFEVNVTGVFMTSQAVAKQMIRFGNGGSIAMIASMSGTVANRGLICPAYNASKAAVLQLARNLAAEWGTYNIRVNTISPGYIVTAMVEKLFVEFPERRDQWPKENMLGRLSRPEEYRGAAVFLLSDASSFMTGSDLRMDGGHAAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NTT3</accession>
    <name>A0A0G4NTT3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S001g000334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NTT3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL17374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="33" mass="3697" checksum="19713408A81C4DBC" modified="2015-09-16" version="1">MTVHLCIWLHKIWGKVNICADFPFPPPTSKGCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NTW6</accession>
    <name>A0A0G4NTW6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">acid phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S001g000473</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="2"/>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4NTW6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Acid phosphatase PHOa"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956:SF23">
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    </dbReference>
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    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005194785" description="acid phosphatase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL17513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="413" mass="45637" checksum="459E6E2144223FC6" modified="2015-09-16" version="1">MLTKQTLLAFVGALALAAAKTTTEKTPTQAEIDAARDTVLPYSPVSNVKGLAFDRFVNIWLENTDYETAASDENLSKLAKEGILLTNYFAVTHPSEPNYCASAGGDTFGMDNDDFLQIPANVSTIADLFDTKHIAWGEYQEDMPYAGYQGMRYPLSGPNQYVRKHNPLVLYDSVTDDAVRPRQIKNFTTFYEDLKHHSLPQHMFITPNMTNDAHDTDITVAGDWVDRFLPPLLKNEHFNKDSLVLLTFDEGGNYSHPNRVFSFLVGGAIPTHLKGTTDDTFYTHYSIIASLSANWGLPSLGRWDCGANLLNIVAEKTGYVNWEVDTSNAYINQTYPGPLSTENYSSKWAVPATKGKCSAGHGIAEVVKKTYHGLQPTYDYTSPVPYDAASGNNVGIKYHRTLKDGKTESGITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NU41</accession>
    <name>A0A0G4NU41_PENC3</name>
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        <submittedName>
            <fullName evidence="3">Class II aldolase/adducin, N-terminal</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">PCAMFM013_S001g000562</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4NU41"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:actin filament binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
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    </dbReference>
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        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF40">
        <property type="entry name" value="CLASS II ALDOLASE_ADDUCIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G09800)"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="249"/>
        </location>
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            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL17602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="303" mass="33022" checksum="6A1ABA03096C6520" modified="2015-09-16" version="1">MSTSTTTTQQEQSVRVINEDQLPPLPPAANDASFQGLARGGRNGTLKLRGIPTFSDLTEKRKWMKEHMAAAFRYFGKLGYGEGVSGHISMRDPILKDHFWMNPFAKHFSTIKASDLVLLDADGFVVDGGAQLPVNEAGFLIHSEIHKARPDVTAAAHTHGIHGKTWSSFGKPIEMLTQDACNFFGRVGVYEDHGGIVLSAEEGKAIAKALGKENIACILQNHGLLTVGRTVDEAAILYSMLENACQSQLLAEAAAANGLPKKIIKDDAAKFTADAAQNPHNFYTEFQPEFDLLVEETNGRFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NUT0</accession>
    <name>A0A0G4NUT0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S001g000739</name>
    </gene>
    <organism evidence="7 8">
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4NUT0"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
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        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF11">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="4"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="54"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL17779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="621" mass="69389" checksum="167A594EC1895646" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NV32</accession>
    <name>A0A0G4NV32_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chitin-binding, type 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S001g000891</name>
    </gene>
    <organism evidence="4 5">
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        <lineage>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NV32"/>
    <dbReference type="STRING" id="1429867.A0A0G4NV32"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053214">
        <property type="entry name" value="LysM12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700:SF2">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700">
        <property type="entry name" value="V CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="82"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL17931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="283" mass="29762" checksum="28CB9855B948B3BE" modified="2015-09-16" version="1">MYFLTFRQVSNADWIIGVAIDTTGDLASVQSSVHSWSNGKCATIPGTHGTVQKVTVVEEPLRSTSTNTTAVPDKLSKRSDCKTTTVSSRDSCAALATKCGISASDFTKYNTEKNLCSSLTPGQRVCCSAGSLPDIRPKPNSDGSCHSYKVQSGDTCAPIAAANGLTQAEIDKFNDGTTWGYAGDPPMPASLPGAEYGPIKPGTTKPTNGTALADLNQCPLNSYCDKWGQCGITPEFCTKSTSPTRNPGTAPAGQNGCISNCGTKIVKSQIAPTEFWNVGYYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWF8</accession>
    <name>A0A0G4NWF8_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL13m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S002g000322</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWF8"/>
    <dbReference type="STRING" id="1429867.A0A0G4NWF8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000007">
        <property type="entry name" value="50S ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_uL13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL18452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="168" mass="18753" checksum="A0C6B6116BC41EB6" modified="2015-09-16" version="1">MSQLVGKTRLAYSRTWHYVDAGADERSLGRLASSIALVLMGKNKPIYDPSTDCGDYVVVVGCHDLKTTGKKRFQKKYYTHTTRPGSLKSMTMDQMFAKWGGGEVLRRAVRGMLPKNRLKDARLARLKTFEGVAHPYKENIVKFGNQSVIGNLPEVQEAFKEAADKPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWT7</accession>
    <name>A0A0G4NWT7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S002g000443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWT7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL18573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="87" mass="9723" checksum="25B8E50CF719CE96" modified="2015-09-16" version="1">MHEPIYGFYRHGLAPEPLTPENSEKFDVATVSAQALGPLGTLSLFWARAIYRVNNKARGQCHAFHCWLHSGVRSLDKGGRKSYSSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NX71</accession>
    <name>A0A0G4NX71_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S002g000510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NX71"/>
    <dbReference type="STRING" id="1429867.A0A0G4NX71"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005194975" evidence="1">
        <location>
            <begin position="23"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL18640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="232" mass="24933" checksum="E349E482F1C97F73" modified="2015-09-16" version="1">MKATLVVSVMLASLAMASPAQPQRTVACKVDNDCKPNEQCNNVGQCIPSKATRDAPLAKVGQACQSTSECIKGLVCDQDKNTCDAPNTHNKRGDTLSQLGQDCKATKDCVKGFVCDQDKNVCVAPKDKRDNTPKLQKCKSTGDCAKDQVCDEDKNVCVVPNNKRDIAPQLQKCKSTGDCAKDQVCDEAKNVCVVPNNKRSEGKDQCQTDVDCSKKETCQVIKGNKVCAAPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXP9</accession>
    <name>A0A0G4NXP9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="10">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S002g000629</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="10"/>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NXP9"/>
    <dbReference type="STRING" id="1429867.A0A0G4NXP9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF0">
        <property type="entry name" value="HOLOCYTOCHROME C-TYPE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL18759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="288" mass="31011" checksum="79BEF9EDC31164EA" modified="2015-09-16" version="1">MGAAASTPSAPSVEPPAATCPVDHKTREVWLQQNSNSPLPTSDVPAEQGQPRAKAQRPLSTDREVSTIPRAGDFSSAGACPEANKGSPSPYAASHGSPSNAESETGRDEATGNWIYPSEKQFFEALMRKGNTPGSTASASELATSVASIIPIHNAVNERAWDQILEWEKKGPSADPGSKKCGGPKLYSFRGLGVDPQYLSPRARINGWLGYQHPFDRHDWVVERCGGEKVEYVIDFYQGKPSEGNGTPSGLAANANAAPGKLSFFLDVRPKLNTYEGWRLRFNHFTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXR5</accession>
    <name>A0A0G4NXR5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S002g000748</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4NXR5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000597">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001638">
        <property type="entry name" value="NACHT and WD40 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="477"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="65"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="NACHT" evidence="6">
        <location>
            <begin position="652"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1177"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1220"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1323"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1365"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1445"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1486"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1568"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1630"/>
            <end position="1664"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1680"/>
            <end position="1721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL18878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1851" mass="204456" checksum="05F17E51360E06F0" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXV6</accession>
    <name>A0A0G4NXV6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA mismatch repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S002g000765</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZ42"/>
    <dbReference type="STRING" id="1429867.A0A0G4NZ42"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000058">
        <property type="entry name" value="Enoyl-CoA hydratase/isomerase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000001">
        <property type="entry name" value="Probable enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF171">
        <property type="entry name" value="SD19268P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL19331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="311" mass="33389" checksum="9FCA7040AAA690F5" modified="2015-09-16" version="1">MASIMSTRLVRLSAPLAHLRATAVPTRVFISRYSTSTEEDIIKTQQIPAPGSGHVRVLQLNRPKARNAISTHLLDTLSKHVDAIAAEGGNGPTRALVVASNADAAFCAGADLKERANMSMAETEDFLLKLRATFQKLASLEIPTISAVSSVALGGGLELALCTHLRVFASSSVVALPETRLAIIPGAGGTYRLPPIIGVNRARDMILTGRRVTGPESYFIGLCDRLVEVLPEEEAQEGVARERVLRESIKLALDICEGGPIAIKMAMQAVGAHALGERAENAAYEAVVETDDRYEALRAFVEKRKPAFRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P1V8</accession>
    <name>A0A0G4P1V8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Splicing factor PWI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S004g000209</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P1V8"/>
    <dbReference type="STRING" id="1429867.A0A0G4P1V8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036483">
        <property type="entry name" value="PWI_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052225">
        <property type="entry name" value="Ser/Arg_repetitive_matrix"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148">
        <property type="entry name" value="SERINE/ARGININE REGULATED NUCLEAR MATRIX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148:SF0">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00311">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101233">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51025">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWI" evidence="3">
        <location>
            <begin position="12"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="130"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="232"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="364"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="377"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="395"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL20269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="517" mass="59862" checksum="CB03E893EC51CB92" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P2G2</accession>
    <name>A0A0G4P2G2_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">pectin lyase</fullName>
            <ecNumber evidence="12">4.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCAMFM013_S004g000379</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Pectinolytic enzymes consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan methyl ester to give oligosaccharides with 4-deoxy-6-O-methyl-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.10" evidence="12"/>
    <dbReference type="EMBL" id="HG793137">
        <property type="protein sequence ID" value="CRL20438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P2G2"/>
    <dbReference type="STRING" id="1429867.A0A0G4P2G2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047490">
        <property type="term" value="F:pectin lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000003">
        <property type="entry name" value="Pectin lyase F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PECTATE LYASE 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683:SF16">
        <property type="entry name" value="PECTIN LYASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00544">
        <property type="entry name" value="Pectate_lyase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00656">
        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 13 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013288920" description="pectin lyase" evidence="14">
        <location>
            <begin position="16"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Pectate lyase" evidence="15">
        <location>
            <begin position="80"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CRL20438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="381" mass="39957" checksum="E59FD8E59B7AB27E" modified="2015-09-16" version="1">MKFSLALFFAAVAVADSPAKRAGTISVTGSPPGFAYGVTGGGNAAPVYPTDVKNLIELLGSDDPQVIVIDKTFNFIGTEGTTKGTICKSYGAFEDGCQSTIDIGNGCDGKPSEQYEWDTAGTQGIRVHSDKTIIGVGNKGVLLGKGLRIVEASNIIIQNIMITNLNPQLVWGGDAITLSNTSNVWVDHVTTQYTGRVHYVFGQEANAHVTISNSFMNGATNFSTSCDGQQYWGLELVGADDQITFANNYVYRTSGRSPALSGKTLFHAVNSVWENNSGHAIEGTDDGQGLFEGCVFNNVTQIVGDYVGQLFSSPDATANKACSAALKRDCETNIIVDSSAFTNADTKFFSNFAGLTVATASAASAAQASVPTTAGNTLNNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P3W0</accession>
    <name>A0A0G4P3W0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S005g000148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL20984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P3W0"/>
    <dbReference type="STRING" id="1429867.A0A0G4P3W0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF11">
        <property type="entry name" value="ESTERASE_LIPASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="9"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL20984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="253" mass="27037" checksum="B8006FEB6FA7504C" modified="2015-09-16" version="1">MPSTTKPTIILVHGAWHGSWCWKFQIPALEALGYAVEAVDLPCVNGVPGTTQFDDADHVRSVVESQISMGKRVVVLAHSYGGPIASAAIKGLSDKGVLGMIALSAFIFPGGMDQGAVIRDIGGLPYVTWDMPSEGLFQTKDPRSLFFPPDVSADLVDWAVPQLRPQSMAANMGIVPPQSWEDDSYTGRLGYIRCTGDVVIPIGQQDAMVEGAGGQGKWVVRTLEGSGHSPFLSQPREVAAALEEIVNAFEAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P417</accession>
    <name>A0A0G4P417_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S005g000213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P417"/>
    <dbReference type="STRING" id="1429867.A0A0G4P417"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022085">
        <property type="entry name" value="OpdG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12311">
        <property type="entry name" value="DUF3632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL21049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="273" mass="30377" checksum="543F18390D10B6A9" modified="2015-09-16" version="1">MLDVSGSNPPNPFSRSIQAFLTSRNHFHFPTPTPAETAADLVNSVATSSDPAHALWELWDAFFTAVATSSTSHDPHLALLDALHAHPPTQLNVRARSNTSSYIEADGKLHWQTLPRFSAQWRDVHDILEAWRDWDGVLDSGAGNSTISKFSSSGGEYFLRFCVFSAAVLKASKAKAHRVSSEQLWALDVHVAATWMRDGGRALWEADYEELRYWGALDDKTELWLRGGLTRERWILWGKRLRPLNIQGILEEETVAVVIEAADVVSGILEGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P477</accession>
    <name>A0A0G4P477_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S005g000310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P477"/>
    <dbReference type="STRING" id="1429867.A0A0G4P477"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195153" evidence="2">
        <location>
            <begin position="25"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL21146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="327" mass="34097" checksum="6296309C823D355A" modified="2015-09-16" version="1">MLSSIPISSFTTLALSLLTNIATSTTIEKNEPQLLSNISLIADDGFSLFTENPSLNARALECNIGYSECAYDTSRCCPSSGKCCGNGYCADIGDTCCTGGGTCPVGYKCCDGTRGCAPLGGECCSGGYYCRAGKKCRIYDGEKVCCPLSGCIGEYDGIGSGGTLTVPDVTSTATETEIETTRATTTYVEVDWDYYYTTIYWTYWFYYWTSYAPYTVQTVTSTTTSTRTIWSIYATNRAEATSSLSRSSARYSFSTPYEATSLKSSTAPVTLSTGAAAPSATVSDSTDDTVAAGPVIGASSAESVGVSGTGILAAVLVAAVGGLAFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P499</accession>
    <name>A0A0G4P499_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S005g000330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P499"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053037">
        <property type="entry name" value="Pericyclase_pydY-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115:SF1">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL21166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="220" mass="24224" checksum="DB810241330FAA5B" modified="2015-09-16" version="1">MAAPADVTIQNLSGKWKMDSTHSNPSDPLLSLQGIGWVTRKALSYATVTVNVHQYTDSENPTLIHVDAQQVITGGIQGTKEERKLDWTEREHVDHIFGTLKGLSRHIAGAKSEDGAVRPVIEIQTKVGSPEADAQVRKFLTGETLIDGSKSEGFLAEEGEAAFLQSFVVNESAGWTAEQVWGFELVDGERRHTRRVVVVKNGKVASARLVYAFKERRAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P4A4</accession>
    <name>A0A0G4P4A4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ORMDL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S005g000272</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P4A4"/>
    <dbReference type="STRING" id="1429867.A0A0G4P4A4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
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        </source>
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        <source>
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        </source>
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    <sequence length="281" mass="31720" checksum="D6D1C4EB06ADA290" modified="2015-09-16" version="1">MHTFVHRSKKKEKRKRCPGESESSSAPRDRKPIRPANSSLGRATSSPRSFSFFFPSLPTYSFLLDPTVKLASDNSKVSSLLAPRGISFPPDVDTGPQRLSPSMTSKQGRRRRSSSLIYQEPAESIEHTSDQAALPNLNANWVNAKGAWTIHFVCIAALKIFYDIIPGVSQETSWTLTNISYMFGSFLMFHWVRGIPFEFNAGAYDNLNMWEQIDNGDQYTPAKKFLLCVPIVLFLLSTHYTHFDLTHFTINFLATLGVVIPKLPFSHRLRIGLFSDIPEES</sequence>
</entry>
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    </organism>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <authorList>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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    </evidence>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P532</accession>
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        </submittedName>
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    </organism>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL21408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="115" mass="12614" checksum="5C36F2ADDFFDF257" modified="2015-09-16" version="1">MVVSSAEPAIIFGTTLHGRDPISPYVAEAVGPTILTVPVRVSLKNEQSPGELIQDIYNDSAIVLAHAHLGLYQISRLGPDTRRACDFQHIFLVNNASTEHHHGSKNYIYIAIIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P567</accession>
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    <protein>
        <submittedName>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL21461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="140" mass="15599" checksum="1089FE72A3FAA0CE" modified="2015-09-16" version="1">MDVLGPEGFILDFPRSQAIIESYENRSFPIALCAKPHHVSKRPVYASSKVEIPPRQAAQVPIMVKSALPKDCDYIFKPGRSRFKIPAQMVDAGFSYIHAVNNTNHTQVIRKKDCVGQLLEPDYTSAYHVVTKATSLATLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5A2</accession>
    <name>A0A0G4P5A2_PENC3</name>
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        <submittedName>
            <fullName evidence="7">Alcohol dehydrogenase superfamily, zinc-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S005g000618</name>
    </gene>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF1">
        <property type="entry name" value="TRANS-ENOYL REDUCTASE STHE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="19"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL21454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="360" mass="38100" checksum="A5D562503E32C6BB" modified="2015-09-16" version="1">MAASIPKTQTAIIAADEEGTLRIAQDVPVIDLEPDSVLVKTAALALNPVDSKMAKGFAVPNAILGFDFAGVVVAIGTGVTRQDLKVGDRVLGTADSMDRKRPSGGGFCQYASTVATQALRLPDDMSFADAACMGTSLSSAGIALFRSMKLPGSLSAPNSAASPPHVLVNGGSTSTGTMALQLLKLAGFRPIATCSPSHEELVLSYGAEKTFDYRSPDCAKDIRSYTKNALAYAIDCITATSSMKLCYEAIGRAGGRYTALDPYPEAQATRKVVKPDWILGSTVKGRGSSWVAPYGRDADPDARTFADELYGGAQKYLLEGKLKNHPANVMSGEFSGILEGLEMIRRKEVSGFKLVYEVHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5A7</accession>
    <name>A0A0G4P5A7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCAMFM013_S005g000623</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793138">
        <property type="protein sequence ID" value="CRL21459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P5A7"/>
    <dbReference type="STRING" id="1429867.A0A0G4P5A7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195052" evidence="10">
        <location>
            <begin position="22"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602402-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CRL21459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="524" mass="59435" checksum="63D5E0752EC04BFF" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5C8</accession>
    <name>A0A0G4P5C8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S006g000055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P5C8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL21515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="132" mass="15056" checksum="A16D1A8818241051" modified="2015-09-16" version="1">MECFRQIFRCLKAPLRRDKGRIIEIGPPTNFRKEELPAYFSDAESDAYVPGQLHSDRGEGRNDDRNGISTIVAEEQDAGPCSKDERETVIRLRERVKLSRWWKSSSAAGHKTKAPAESIKMEEMRNTELACS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P5W4</accession>
    <name>A0A0G4P5W4_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Very long-chain fatty acid transport protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Very-long-chain acyl-CoA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PCAMFM013_S006g000227</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Acyl-CoA synthetase required for both the import of long chain fatty acids (LCFAs) (C14-C18) and the activation very long chain fatty acids (VLCFAs) (C20-C26) by esterification of the fatty acids into metabolically active CoA-thioesters for subsequent degradation or incorporation into phospholipids. The transport and fatty acyl-CoA synthetase activities are genetically separable and are thus independent activities. Esterifies VLCFAs in the peroxisome matrix. The VLCFAs are actively transported into peroxisomes by a PXA1-PXA2 heterodimeric transporter in the peroxisomal membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54536"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P5W4"/>
    <dbReference type="STRING" id="1429867.A0A0G4P5W4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000002">
        <property type="entry name" value="Long-chain fatty acid transport protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000019">
        <property type="entry name" value="Long-chain fatty acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF6">
        <property type="entry name" value="ACYL-COA SYNTHETASE FAMILY PROTEIN (CEFD1), PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 22" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="13" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="20">
        <location>
            <begin position="60"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="21">
        <location>
            <begin position="498"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00078285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CRL21687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="632" mass="70384" checksum="1254C47D91794590" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P644</accession>
    <name>A0A0G4P644_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S006g000322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P644"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL21782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="84" mass="9402" checksum="DC0D9F62155107F8" modified="2015-09-16" version="1">MTRPVPLANRGNDDSVVVTCLSKALSDTYFLAPVPLAHRGNDDFVVMKLLRLAVEKGAVIALKIGGIVLLFLFLRDLFTFFFFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P650</accession>
    <name>A0A0G4P650_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcriptional activator of proteases prtT</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Zn(2)-C6 zinc finger-containing protein prtT</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S006g000323</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the prtT family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793139">
        <property type="protein sequence ID" value="CRL21783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P650"/>
    <dbReference type="STRING" id="1429867.A0A0G4P650"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF34">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR OF PROTEASES PRTT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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</entry>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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</entry>
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    </dbReference>
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</entry>
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    <accession>A0A0G4P7C8</accession>
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    </dbReference>
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        </location>
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        </source>
    </evidence>
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    </evidence>
    <sequence length="215" mass="24691" checksum="A6390B59273184BB" modified="2015-09-16" version="1">MFGPFVSSFEAKNQQKAYTIIDPDIVTVPWVQDFFMDDEGWGYIISDFIQGKIIDPLTDSHILRLAHILEYFRSITADRAGSLCGGPSIGLLWPDTNDLTISNIQQVEEWFNSRLFPGDGKVHFDTTLLVLCHLDIAPRNIIWLDDSRVCLLDWASAGFYPRLLEFASLFFQQCQFGEMLLKAVGFGSGRDREEQQRICQALYNNERYSLYVRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P7D5</accession>
    <name>A0A0G4P7D5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NAD(P)-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S007g000234</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FMP52 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P7D5"/>
    <dbReference type="STRING" id="1429867.A0A0G4P7D5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051170">
        <property type="term" value="P:import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000366">
        <property type="entry name" value="Protein FMP52, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097:SF7">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="7">
        <location>
            <begin position="6"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL22253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="229" mass="24685" checksum="AF62864114FB90BF" modified="2015-09-16" version="1">MTTAAIFGCTGAVGSQILATLLATDTFSTVKTISRRLPNAQSAKLEALEESDTSKWGGMISSLSPKPSTVFNAVGTTTATAGSIKNQWKIDHDLCVENAQAAKEAGVKTYIYISSGGTRSLLWGWVPYSKMKVGVEDAIKELNFDNAIILRPGMIIGREESKSFLLEKFVEGLQKLGQGVQDKVGQNQTTIGRAAVAAARVAEEGKAPSNYWVLEQADIVRLGRDEWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P877</accession>
    <name>A0A0G4P877_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S007g000519</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P877"/>
    <dbReference type="STRING" id="1429867.A0A0G4P877"/>
    <dbReference type="ESTHER" id="penca-a0a0g4p877">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000266">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005118109" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="24"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="30"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL22538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="599" mass="65126" checksum="78B36EF5B24C8F62" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P8C1</accession>
    <name>A0A0G4P8C1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S007g000495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793140">
        <property type="protein sequence ID" value="CRL22514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P8C1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL22514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="171" mass="19854" checksum="0F7A300098036DE6" modified="2015-09-16" version="1">MASEDTPPDFVNRMEKVPAPYLSEQYGYSKDGLSCAMIAWMLDLDVRAAIKKREFQRTYQRMCLYIKHMERLMDQANIKYDPYTGAEDGRRMKIARDTFKPQLKARFMTTAPYPVTAPISTDGELCRSVSDAQTFEYKLHQLEILRYMERVDGPALTDFETSTRQPRPETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P9X2</accession>
    <name>A0A0G4P9X2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sucrose/H+ symporter, plant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S009g000056</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P9X2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF252">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="243"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL23116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="438" mass="47508" checksum="FE66A66ED6D064DD" modified="2015-09-16" version="1">MGSTEETHGAQPHLPPASGNLAPENHHEHEQPKKRINGGLDAWLNVLAGFCVFVNSWGLLTTYGAFQEYYQTELLPNETPSTISWVGSIQATLIPMVGLATGPLVDIGYLRPLIISGSFLTVFGMMMTSLATSYYQVLLAQGFCVGMGGGISYIPALVVISTSFTTKRPIAIGCASIGSSVGAVIFPVMFRQLQPKIGFPWAVRCIGFISLFLAIVACLILCRQPGQRAHARSLIDWKAFREPSFMMFSLSLTCVMLAYYVPIFYIASYARTVVHTTTDFSFYMVAIVNGTSVIGRVVPYLLVAYIKPIGILIFSVTASAIAMFTWIAATGMAGFIVWACYWGALSGVLVTAPTSIVAHPIFCQDSSFLGTRLGMMWGISSFGALTGTPIAGALVNLDTAQFLHAQVFAGCMMVGAVLLQIWPTFRVVRYDLEHPRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAM5</accession>
    <name>A0A0G4PAM5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Alcohol dehydrogenase superfamily, zinc-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S009g000312</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PAM5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PAM5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08282">
        <property type="entry name" value="PFDH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF3">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT FORMALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="9">
        <location>
            <begin position="36"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="8">
        <location>
            <begin position="190"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL23372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="381" mass="40975" checksum="FB18ED666493C166" modified="2015-09-16" version="1">MAETHSNNKTMRSVIFDGHPFKIHVRDIPKAKVVKRTDAVVRVTTAAICGSDLHNYHGVFGSTKVPYPMGHEAMGIVEEIGADVDSVKVGDRVIIPDIPNAVGLDLEPAIIPVVPLYGEGSDFGNLGGCQAEFVRVPLADKSLIVLDKEFDEIKDKDLVVLSDIFPTAWTGVSWSGFEAGDKVAIFGAGPVGLLAAYSAILRGASRVYSIDCVEDRLELAASIGAIPINFIKGEPAAQILAREPGGVRRTVDCVGEECVNEELKHDQSFVITQAAKCTSVGGGLGVVGVHFAEPNSEGVQRGDTISPYMMFPITLFWEKNMTIRGGVVDSKLFVEPLLELVKSGVAKPGFVFSSTVGIEEAPKAYQRFSDHLETKVMIKFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PAT8</accession>
    <name>A0A0G4PAT8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S009g000350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PAT8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PAT8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL23410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="307" mass="34684" checksum="1651B1AAAC71639D" modified="2015-09-16" version="1">MTGFVTSSDKWPAICETRSLLALFYRPTTRQYFSQRLIAKAFGLFQRGEDNASVRFHATLDRLREGRHTRADFELPATRVIANNPADIAAFADSLRILPRRTQVELYNHDQPRDLRQAVLTLTADHTGKGAKGASIEEAGNLYSSVQLSIGSRVILLENLWTERGLINGSFGTVEDIVWASGTRDSRCEPPLRYRASNVQHQAKPQSHPCIPSYASTAMLGDGQDLSDLLAWAHRTFSLDWVDNDSADGFHDWPYSMETCRVVAERMMELCKSFDPSEQAHRKEHELTRNKAHVKQTTPSCRRPKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PB68</accession>
    <name>A0A0G4PB68_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ankyrin repeat-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S009g000475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793142">
        <property type="protein sequence ID" value="CRL23535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PB68"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="65"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL23535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="117" mass="12893" checksum="125A187BEB283B77" modified="2015-09-16" version="1">MEQHIQTELQYLVTQAISLHGPRVDHDTQTLARHILASDPLLSNRPIYMNAPTGSFWIKTTMWGSALASATLEGHTEVGRILLEHGADVDIRGGLFHTPLQAACVKERPNVFTDHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBH8</accession>
    <name>A0A0G4PBH8_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane fusion protein PRM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S010g000115</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PRM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PBH8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PBH8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032220">
        <property type="term" value="P:plasma membrane fusion involved in cytogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026777">
        <property type="entry name" value="PRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030:SF1">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0184">Conjugation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="396"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="603"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="639"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="715"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL23677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="734" mass="80222" checksum="BA11CA5991A1101D" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBM6</accession>
    <name>A0A0G4PBM6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S010g000159</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PBM6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PBM6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF135">
        <property type="entry name" value="SET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G11040)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL23721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="679" mass="76236" checksum="323F8AC0F95C0144" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PBP3</accession>
    <name>A0A0G4PBP3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pyridoxal phosphate-dependent enzyme, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S010g000148</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PBP3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PBP3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006058">
        <property type="entry name" value="PRK08206.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42937">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42937:SF1">
        <property type="entry name" value="DIAMINOPROPIONATE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="3">
        <location>
            <begin position="35"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="4">
        <location>
            <begin position="548"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL23710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="755" mass="79800" checksum="68A1BEEE957B93E6" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PC72</accession>
    <name>A0A0G4PC72_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Actin/actin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S010g000307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793143">
        <property type="protein sequence ID" value="CRL23869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PC72"/>
    <dbReference type="STRING" id="1429867.A0A0G4PC72"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10210">
        <property type="entry name" value="ASKHA_NBD_Arp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000036">
        <property type="entry name" value="Actin-like protein ARP6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Actin, Chain A, domain 2"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Actin"/>
    </dbReference>
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        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
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    </dbReference>
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        <property type="entry name" value="Actin"/>
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    </dbReference>
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        <property type="entry name" value="ACTIN"/>
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    </dbReference>
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        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL23869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="469" mass="51621" checksum="04C17626A0953567" modified="2015-09-16" version="1">MGTAKARAPPRTPATSTQPVETSRYLPDKTFIIDNGAYMIKAGYASDAASDESVSACSSIPNALVKTRDNKIVIGAQLATVNDWNEAMFRRPVEKGYVVNWEAEREIWDQSFFDGKPTARNRNYHIADPEDTTLVLTEAPNALPILQRHADEMVMEEWGFGGYARCLGPTLNAWNEIHSLFGDPLSNTSGASILPADCLLVVDSGYSHTTVTPVYKGHALQRGIRRLDLGGKHLTNYLKEIVSMRQYNMVDESYIMNEVKEAVCYVSNDFAGDLEQAWKSGRKRQSGPEEGIVLDYVLPDPNANKKGFIRPHDPLLHAKKKKGAVSGLSAEVLSEDVLVLGNERFAVPELLFTPGDIGMKSAGIPDMILQSLSVLPTGLHSAFLANVLVVGGNALIPGFMERLETELRQIASAECVVRVRRAKDPVHSTWLGGTRLASNREELSKVSITRQEYQEYGSGWAVRRFAGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PDH6</accession>
    <name>A0A0G4PDH6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S011g000362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793144">
        <property type="protein sequence ID" value="CRL24368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PDH6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PDH6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL24368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="339" mass="38150" checksum="0B3878BC397F32F3" modified="2015-09-16" version="1">MGLKHGYTGCWHSIPASTAYISTLFIIKQRIGTSPTSWAKPKSAWKISHWKKDLESLCTEYNIGDCNAAIRGQKIPGALGLKVQRFAVIRGIRHHDGFAHELRGVAPEFTRALNARAIMSGVIPEINDSPEIPYCIWYPEPPSQETLRKLVKRYPNMIYHAARSCAVAGYFDLYSELQVLPEVHVAAEARDASLARKNKGSEAIYEQIMSNHLKFEIMNDYDRSVNLENPRPAHLNGDTAVFSDLTARMLHAGVDNSSKRSVNLVDYIEWDSKEYNTYNHFNITEDMGIDDHSCGAPEPLASFWPLLYSPLPSDLPPVNKDNLILSAAYKGDVDRYVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PE82</accession>
    <name>A0A0G4PE82_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA mismatch repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S012g000247</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
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    <dbReference type="STRING" id="1429867.A0A0G4PE82"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000017">
        <property type="entry name" value="PMS1 homolog 1, mismatch repair system component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF41">
        <property type="entry name" value="MISMATCH REPAIR PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="4">
        <location>
            <begin position="219"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="400"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="611"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="702"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="766"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="429"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="458"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="509"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="539"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="555"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="715"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL24637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="891" mass="97997" checksum="F3C4D7016CAA7720" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PER7</accession>
    <name>A0A0G4PER7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Synaptojanin, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S013g000004</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL24762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PER7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PER7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034753">
        <property type="entry name" value="hSac2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022158">
        <property type="entry name" value="Inositol_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF7">
        <property type="entry name" value="SACI DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G15890)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12456">
        <property type="entry name" value="hSac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51791">
        <property type="entry name" value="HSAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
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            <end position="146"/>
        </location>
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        <source>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51791"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL24762.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="952" mass="105820" checksum="2A002BBA3BD39045" modified="2015-09-16" version="1"> </sequence>
</entry>
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    <accession>A0A0G4PET9</accession>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="121"/>
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        </location>
    </feature>
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            <end position="460"/>
        </location>
    </feature>
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        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
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            <end position="135"/>
        </location>
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        </location>
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        </location>
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            <end position="223"/>
        </location>
    </feature>
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    </feature>
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        <location>
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            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL24828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="460" mass="52088" checksum="7473FA7203004F62" modified="2015-09-16" version="1">MASNPTDLRLHVLELEERLKRAEEGRQQAEEHRQQAEERNRPTTLVELVRFGHTLLSLPLNGLEYSYVTNGIARVLLRVPYENPTLRSPVRDQTWRNNAQSQLYLWKTSFDHIRSRIPEKELQQLPRSADSSFNSDVMGLESDSDYRPSSPPPEPSTEEGCRVSTRSQHTGCAPSDVRHRTGSPDSLGSDTNQAGRKRRISQVTSSPSTRQDARNDRSGQSQRHDAQFCTQRCLLGLQTGGALDNRCPNVTLHRQSQDDLKHPINAEDLLRLLKVQLDKNLDKDCTPFGTCGSYGAPFKLTCAAYGYTVVGKGTTAGLWKEVSREAQIYQILQKAQGSAVPVFLGTIDLALIYFHDAGDISHMLVMGWGGESIVNMELTSSLRREIHRSKKEIRELRVIHEDLRRANILWNHELNRALIIDFHRSKLDPRPISKRSRPAKRKSDRTESPDGNDGKHLRVL</sequence>
</entry>
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        </lineage>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Dupont J."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">FM 013</strain>
        </source>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Amide_Lactam_Regulators"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
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            <begin position="8"/>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="CRL24820.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="564" mass="63778" checksum="73E6E643BE5EB428" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PF47</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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                <person name="Abraham A.L."/>
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                <person name="Goarin A."/>
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                <person name="Lacoste S."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793146">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PF47"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MDR_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chloroplast_QOR"/>
    </dbReference>
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        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
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    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44013:SF5">
        <property type="entry name" value="OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01290)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44013">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C16A3.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="17"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL24900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="341" mass="37007" checksum="72F975A4E63F7018" modified="2015-09-16" version="1">MSTPLPSKMHSIIQQTASSKTLTLTTTPLPTPNHTQGEHLIQIKACSPCAGELLWPKNFPPPTERTLIPCPDMAGIVLAAPQDSPFQPGDEVYARTNYIRPGNAREYSIAVTDELAHKPKSLSWVQAAAVPVSAQTAWQVLFVHALGTHGSEGEMDLEAAKTAWTGKRVLVTAASGGVGIWLVQLATLLGAEVVATCGSRNVELVKSLGAKEVLDYRVVDLKEWATQSPSNKVDVVVDCVGGKTLGDAWWAVKDGGVVLSIYQPPLQVRPDGFDSEGVKDLFFVMQPVRRQLEEISKLVEKGLCRGLVDSVWPLEQYEEVFKRLDGGHAKGKIVFDLSLNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PF73</accession>
    <name>A0A0G4PF73_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S013g000190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL24947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PF73"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL24947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="71" mass="7874" checksum="EA6939016A6308B9" modified="2015-09-16" version="1">MRFTSMAKVNLWSYGSLASSTQTHAQSSAAGDRLSSTTRLGSSRRGRLSIVAREMSCRSVTPSYHRHSFYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PFL8</accession>
    <name>A0A0G4PFL8_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial</fullName>
            <shortName evidence="7">Glu-AdT subunit A</shortName>
            <ecNumber evidence="7">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S013g000313</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="7"/>
    <dbReference type="EMBL" id="HG793146">
        <property type="protein sequence ID" value="CRL25070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PFL8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PFL8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF7">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="8">
        <location>
            <begin position="33"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="7">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CRL25070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="500" mass="53378" checksum="9346232A971B7C6F" modified="2015-09-16" version="1">MSLLREAEKCVANQYAHGFNAFITPLARAGPWLDRVKEADVRKEEGKPKSAVDGRLISIKDNICTRELPTTCASGILDKFTSPFNATVVDQLEAAGAIVAGKTNLDEFGMGSHSINSHFGPVKNPRQDFSLEDLSAGGSSGGSAASVAAHQCYASLGTDTGGSVRLPAAYTGTVGFKPSYGLISRWGVVAYANSLDTVGILGKTTANVRDIFDILNQHDQRDPTNLSISSRSRIQASLQTPQLASRLTSAPLRIGVPIEYNVSELTPSVRRAWALSLAHLKKQGHTVHSVSLPDTKHALSTYYVVGPAEASSNLAKYDGVRYGTRAEGPDGDGKPDGYLFSNTRGQGFGQEVKRRIVLGTFSLSADAIDNYFIQAQRVRRLVQQDFDAVFTAKHPLAAQGADKIAKENDVDVIICPTAPSSPPRLSDLMSKTTKQSPLDAYVTDVFTVPASLAGLPAISVPVTVSGEKDAELAGIQVIGQYGDDQLVMKVGEMLEGRNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PHJ5</accession>
    <name>A0A0G4PHJ5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kinesin, motor domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S016g000029</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793149">
        <property type="protein sequence ID" value="CRL25748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4PHJ5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000125">
        <property type="entry name" value="Kinesin class 4 (Chromokinesin group)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
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        </source>
    </evidence>
    <sequence length="64" mass="7432" checksum="D30FD987900268DD" modified="2015-09-16" version="1">MKDQDSARSNIRIALDSYCRRWPCKSQKYWNLGLECAMYYDAGVAAVYICTLETRIIKVHLSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PIV6</accession>
    <name>A0A0G4PIV6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidyl-prolyl cis-trans isomerase-like 2</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
            <ecNumber evidence="7">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Cyclophilin-60</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Cyclophilin-like protein Cyp-60</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">RING-type E3 ubiquitin transferase isomerase-like 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Rotamase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PCAMFM013_S017g000119</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 23">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EC" id="5.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="HG793150">
        <property type="protein sequence ID" value="CRL26136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PIV6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PIV6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16663">
        <property type="entry name" value="RING-Ubox_PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000079">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000014">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase cyp65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026951">
        <property type="entry name" value="PPIL2_U-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF1">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN-PROTEIN LIGASE PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0697">Rotamase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="20">
        <location>
            <begin position="42"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="19">
        <location>
            <begin position="310"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="227"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="476"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="493"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00020592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00033051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CRL26136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="573" mass="62150" checksum="C5E738A3D485F7AB" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJA5</accession>
    <name>A0A0G4PJA5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Succinate dehydrogenase/Fumarate reductase, transmembrane subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S018g000107</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome b560 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJA5"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJA5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03499">
        <property type="entry name" value="SQR_TypeC_SdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1300.10:FF:000008">
        <property type="entry name" value="Succinate dehydrogenase cytochrome b560 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018495">
        <property type="entry name" value="Succ_DH_cyt_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02970">
        <property type="entry name" value="succ_dehyd_cytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978:SF5">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01000">
        <property type="entry name" value="SDH_CYT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01001">
        <property type="entry name" value="SDH_CYT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL26414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="187" mass="20229" checksum="8A30CE9A45186F38" modified="2015-09-16" version="1">MFSQKVVQQSMRRLAVQQPFAMRSSMMGASPMAVALGKNIQTRQVTSAPNTEDPSQILVKQRLQRPIAPHLTIYKPQIGWIGSSLHRITGVALSGSLYLWATAYLASPALGWHLESASMVAAMGALPLVAKVLLKTTLALPFTYHCMNGIRHLMWDLGRGLTNPVIIKTGWTVIGLSVASAVGLALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJE1</accession>
    <name>A0A0G4PJE1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S018g000215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJE1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL26522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="538" mass="60554" checksum="523A733888473488" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJE8</accession>
    <name>A0A0G4PJE8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S018g000001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793151">
        <property type="protein sequence ID" value="CRL26308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJE8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027796">
        <property type="entry name" value="OTT_1508_deam-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14441">
        <property type="entry name" value="OTT_1508_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL26308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="476" mass="53907" checksum="0B679472B1B9A3B2" modified="2015-09-16" version="1">MHPSEAKSVSLITAARLYSTHLGMVATLIRTCVYYSFNMPLIDQESNILCAELIVLNYLLSEFPETPSQTRTSQSTPSNKQYRLPFSIERDLVETLSFLSKTQDGPDYIPAVCVEQDQAGDHLNVLLAVNKCSWNDGDDILRSLKERFEDIFHVLCTTEYGRRGGSQGIKQGIFNSIIAMCLPRILCRLRLAPSKRKGIRPSIKELLQTAIDGVGRVNPEKILRLNLGVTLSEFKLLSKKIIQLINNWLKYRVQSRLASILGSIRRLNKISGLPDLLQLIPTGASGIVQDSNFASCLLNIVSKVSRYCQAAGVLYKIAKQYPMVQNMKLQLATLPREAYDRVDNPGYFPNFQEIGPLLGLINGRRYDASRITQYMKLSKNQKDPNETFSREIQKTLKESKIHSEVQLIAYCEIESTPELFPRVIASSKDACYLCNAFIKTHGKLHTSRTHGKLYRSWRLPNLLQMKTYRKNSTGYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJN6</accession>
    <name>A0A0G4PJN6_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylglycerol/phosphatidylinositol transfer protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S019g000062</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJN6"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJN6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00917">
        <property type="entry name" value="PG-PI_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.770:FF:000004">
        <property type="entry name" value="Phosphatidylglycerol/phosphatidylinositol transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033917">
        <property type="entry name" value="ML_PG-PI_TP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039670">
        <property type="entry name" value="NPC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306">
        <property type="entry name" value="NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306:SF0">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL_PHOSPHATIDYLINOSITOL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195732" description="Phosphatidylglycerol/phosphatidylinositol transfer protein" evidence="8">
        <location>
            <begin position="20"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="9">
        <location>
            <begin position="48"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL26645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="174" mass="19254" checksum="4B3EBD87F2645002" modified="2015-09-16" version="1">MKFLSAASLLVLTAPLANAAAFSIFDPTQASLKVNDNEKYPVNGDNPLQYCAKPDNYKLEIESVDLAPNPPLPGQKLTISAKGTLLERIEKGATVNLEVKWGLITLIKQTVDLCDELKNVDLECPLEKGEMILKKEVELPKQIPPGKYTVLADVYNKEQKQVTCLKADDIVFHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PJT9</accession>
    <name>A0A0G4PJT9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioesterase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S019g000040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PJT9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PJT9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000075">
        <property type="entry name" value="Thioesterase family protein, putaive"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="71"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL26624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="170" mass="18515" checksum="2A909E0F3C5B55DF" modified="2015-09-16" version="1">MSGNAIGAPSRKLDEFEELVYEYTARMGLGNEAHWDVDARSCNLRFESATRGPPATVSFLLTITPALSNYMGNLHGGCAATLIDVLSTTILLGISEPGKFSFGGVSRNLKVTYLRPVPTGTEVRLVCEVIHVGKRLALLRAEIQRAESRDVCVIGEHEKANTDPEVTQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PK19</accession>
    <name>A0A0G4PK19_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S019g000121</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PK19"/>
    <dbReference type="STRING" id="1429867.A0A0G4PK19"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF33">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="112"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CRL26704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="703" mass="79900" checksum="0D5BB7B5899432A5" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PK91</accession>
    <name>A0A0G4PK91_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S019g000017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PK91"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL26601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="628" mass="70584" checksum="E3DBE7DDC5973EBB" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PKF9</accession>
    <name>A0A0G4PKF9_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCAMFM013_S019g000108</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793152">
        <property type="protein sequence ID" value="CRL26691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PKF9"/>
    <dbReference type="STRING" id="1429867.A0A0G4PKF9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF37">
        <property type="entry name" value="CLAVALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CRL26691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="321" mass="34743" checksum="AD56215B64D2B4B4" modified="2015-09-16" version="1">MADLASLPKDWILTASQFTRKAHTNVYSAIYPGKADNSLRGKTVVVTGASRGIGARGIAPAFVEAGVKAIVLIATNAVNLVNAEEELKIINPDLETLALGVDVSSCDQVAKAWLEIKARYHKVDILVNNAGVETTDSDKTHEQDPDIFFRNFEVNVKGTHIMTQQFLKAAVSWATTTDPARVINMSSSSAWGTWPFLAAYSNSKAALIHYTTTVAASYPGTVLAIAVNPGLNDTDIIPEALRAAGFNFNDPALTGATLVWLTADPVRSQFLNGRVVTVEWDVEELVARKEEIVKNNLLTMQLNAVLGKGQFAEDFHAFPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PL86</accession>
    <name>A0A0G4PL86_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Basic helix-loop-helix, Nulp1-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S021g000105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684:SF0">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT TCF25"/>
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    </dbReference>
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            <end position="106"/>
        </location>
    </feature>
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        <location>
            <begin position="118"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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            <begin position="1"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL27190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="717" mass="80895" checksum="2481499F8B63051F" modified="2015-09-16" version="1"> </sequence>
</entry>
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    <accession>A0A0G4PL99</accession>
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        </submittedName>
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    </gene>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <sequence length="494" mass="55810" checksum="6EC641B77EA9BE35" modified="2015-09-16" version="1">MQAPMQQHYARAMPPNAQRSPAAPRRPPGPGGAMPVPMPQHAVPQQYMASRPMPHPNDAALRRSRKPTDRNLPDGIEDVIIGEGVQQYKNLRDLEKRLDAAVVRKRLDIQDSINKTVKKYRTMRIWISNTVENQPWQGPGNNPGSGRYKVRIEGRLLDDETDPTVPDEDEKDEDAMDHDGAEEDKAKKSESKTQSQRFSHFFKAITIDFDKPVSAVPDEVKPVNWSKPNTHSNTPAPPTAEFDSLQFSRASQDNLNVTISLVRDEIPERYKLSKELAEVLDVEEETRSGIVLGIWDYIRAMELQEDEEKRQVRCDHRLRSIFGREQMFFPQIPESVGPHTSPMEPIKLPYTIRVDEEFHGAPTPTIYDIQVAVEDPLRTKMMALTQNPAYTSGLRQISSLDDQVALIVQALTHSRARHSFYTALSKDPANFVRRWISSQRRDLETIMGEATRGGGEDGSGPEFRYGGVDGPWDSEVAKEAVRYMLAKPEAAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMA9</accession>
    <name>A0A0G4PMA9_PENC3</name>
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        </submittedName>
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    </gene>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793156">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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        </location>
    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="406" mass="45272" checksum="C58C9DB5EC022107" modified="2015-09-16" version="1">MKSIIFLILSLWRGVQHAQAAAVFAHFMVYNSENFTVYDWEINIAEAQRAHIDAFALNIAYNFPTNNRSLANAFTAANALNFQLLFSFDYVGNGAWPEGEVIGLLRKYGNNTAYYQHNGKPFVSTFEGSSNATDWATIKKYTDCFFVPGWSALGAKEALAVAPGVPDGLFSWAAWPEGPEPINTYIDSTYIQWLKDTGELPYMMPVSPWFYTNLPGYGKNWIWNGDNLWYDRWQQVISLKPDFVEIISWNDYGESHYIGPLHEGAYATFEIGNASYNYAVGHPHDGWRDFLPFIIDVYKGARANVTTEGVTAWFRQAPGKACANGGTMGNTETHGQKEFPPTDLLQDEVFFSALLRSAADVDVSVDIGGVVQDGKWKNKPHGPIGLYHGSVPFDGNTGEVVVTVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PME7</accession>
    <name>A0A0G4PME7_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Beta-xylanase</fullName>
            <ecNumber evidence="10">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S022g000214</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="1429867"/>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
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        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="HG793155">
        <property type="protein sequence ID" value="CRL27534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PME7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PME7"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF35">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 10 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195590" description="Beta-xylanase" evidence="11">
        <location>
            <begin position="18"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="12">
        <location>
            <begin position="44"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL27534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="360" mass="40498" checksum="34AB5E5ABC392DFF" modified="2015-09-16" version="1">MRPFVAITALLACLAQAAPKHQDRNNYNLNALAQARGKQWFGTAADIPGTDETTDTAYLKILKSQFGEITPANALKFMYTEQEQNKFNFTDGDYFMDLAERFDSKVRCHNLVWMSQVSDFVTSKTWTAEELTAVMKNHIFKTVQHFGKRCASWDVVNEAINDDGTFSSSVWYDTIGEEYFYLAFQYAQQALSQIGANDVQLYYNDYGIENPGTKADAVLQLVKNLRKRGIRIDGIGLESHFIVGQTPSLADQLATKKAYIKADLDVIVTELDIRFAEEPYYTADVQKQQAADYYLTVQSCLQAGSRCLGVVVWDFYDKYSWVPETFAGQGGATLFNDTLEAKSAYYAVVEALQGKKCTVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMN1</accession>
    <name>A0A0G4PMN1_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3669 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S023g000072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793156">
        <property type="protein sequence ID" value="CRL27614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PMN1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022137">
        <property type="entry name" value="Znf_prot_DUF3669"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40780">
        <property type="entry name" value="DUF3669 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40780:SF3">
        <property type="entry name" value="DUF3669 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12417">
        <property type="entry name" value="DUF3669"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3669" evidence="2">
        <location>
            <begin position="272"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL27614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="373" mass="42927" checksum="42212ED3FDAA7F47" modified="2015-09-16" version="1">MTQLHNHNHNHNHTTIQPHPHPQSHNHNDTMTSNLLKDTEGVDTSTLHTIGQGFCGTVWAASQTGPAFKREDGGPDRSLINDFEMHHRVIQSFRALPTLQFQTQIPACYGFIEATDQKWWSVNHQKFPPGYTTPCNMIQSQRIPPFSDTTRQLLIRKYCPPKIMQEIIASEPNRDCLVRPYLGRRRTRKPHTTTSQFTAFSLRNFPLHVDQFEELGMTTDDISQYARAMAETLAIMHWVGEIDGNDIEFVLAPPCTDPPLKMGSDVLGDHSIWVLDFDLCRRMAMDSKGVEQAAAAFWGNDPYYPRPGIERDILWSVFREYYLQTSGTCIEIVNEPHEAERRRALSRLFIDLVEQEGKMRQTRKEKEKKANLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMP1</accession>
    <name>A0A0G4PMP1_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein kinase-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S022g000086</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793155">
        <property type="protein sequence ID" value="CRL27406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PMP1"/>
    <dbReference type="STRING" id="1429867.A0A0G4PMP1"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL27406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="323" mass="35864" checksum="83544B363655B100" modified="2015-09-16" version="1">MSSNPFKDNMICDLDTINAQSQLPISMSAPTTCESHTAVTMKLNGPHYRSKVKVVTGPPKSLFLPHLCGLENIASVLIVRQESPWDTYRKVIIYEIAGKVTIAIRRTRPSRMVAIRTYAKENARRLIYRFGRLEHRNVLSLHECYMHEDLAFFLVDDLPLTLAHVVAFPSVYPNETELGSIILDGVFYLFTFGLAHQSLSCDHILFGIDGIIKIASLDLCIDCTPKQSEAAYIAALPSITMQLMQKFDKDQGVVGVIDLERWPIDSAAVGFLSATETAGSIKSLRNQPLLTGKHRPSEDLVVLARAALLSSSLNCVYNPDSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PMS8</accession>
    <name>A0A0G4PMS8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S022g000123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793155">
        <property type="protein sequence ID" value="CRL27443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PMS8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PMS8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL27443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="368" mass="39978" checksum="DE372D2718C5245B" modified="2015-09-16" version="1">MSLNNSPYHPPRSTSSSRQSLHKEIPSQPGTASSRPSDRHPRGQLPEGRPSTDETHQLPGTIESPSQDAALDGPEDHHEEGQEQPFSHPAFQPFFTLIEDAHTSDYHHPTVHYIFSDDDTDIVTEAALRSLAAQQEALSDSKKDQIAQTQESNLQDEIKDPSDPNLAKTTLLPPPIPGVRDNYVILDVEPSPSVPGAAQISPITEQLAPGKDGGGTRSISTSPANASPLPQDQGQLHTQYRVTAAQSFSSTWQVLNTEVVPAPTFENNNPGELPGHGLMLKIRGTGGLPIKVGGKEKESTLEEMMDQFAKRMSELQVIIDAAEDTDSREEHNEEKLVQHPFSPDTAEETIQGEGDSAAYAAEHEAEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PNE2</accession>
    <name>A0A0G4PNE2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger, RING-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCAMFM013_S024g000139</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793157">
        <property type="protein sequence ID" value="CRL27884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PNE2"/>
    <dbReference type="STRING" id="1429867.A0A0G4PNE2"/>
    <dbReference type="Proteomes" id="UP000053732">
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    <sequence length="692" mass="76642" checksum="E125C797C8383694" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <end position="164"/>
        </location>
    </feature>
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            <end position="157"/>
        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="Cdc42"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="Small_GTP-bd"/>
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        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
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        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL28320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="193" mass="21445" checksum="71EC1EAC168B36D3" modified="2015-09-16" version="1">MVVATIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGDEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVTSPASFENVREKWFPEVHHHCPGVPCLIVGTQTDLRDDAGVRDKLARQKMSPIRKEDGDRMAKELGAVKYVECSALTQYKLKDVFDEAIVAALEPAPKKKSRGCRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PPN7</accession>
    <name>A0A0G4PPN7_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCAMFM013_S027g000019</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793160">
        <property type="protein sequence ID" value="CRL28330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1429867.A0A0G4PPN7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10507">
        <property type="entry name" value="Zn-ribbon_RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000024">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019761">
        <property type="entry name" value="DNA-dir_RNA_pol-M_15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034004">
        <property type="entry name" value="Zn_ribbon_RPA12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF14">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01030">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="12">
        <location>
            <begin position="79"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="10"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CRL28330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="121" mass="13242" checksum="91D780CCFD8D66A9" modified="2015-09-16" version="1">MSVIGSLIFCTDCGNLLRESTGNADAILHCDVCGTRNKDTIPQTTVSESKPSAFPSALRAKRSAVQTLSAEDRKTEAIIDRTCNECGRKEMFYTTVQLRSADEGSTVFYRCVCGFKETSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQ38</accession>
    <name>A0A0G4PQ38_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S028g000042</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793161">
        <property type="protein sequence ID" value="CRL28489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQ38"/>
    <dbReference type="STRING" id="1429867.A0A0G4PQ38"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42041">
        <property type="entry name" value="DNA ENDONUCLEASE ACTIVATOR CTP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42041:SF1">
        <property type="entry name" value="DNA ENDONUCLEASE ACTIVATOR CTP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="248"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="369"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="78"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="380"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="474"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="521"/>
            <end position="531"/>
        </location>
    </feature>
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        <location>
            <begin position="562"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="615"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="661"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL28489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="684" mass="76288" checksum="F64A478A7E8A57F2" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PQN6</accession>
    <name>A0A0G4PQN6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">PCAMFM013_S027g000130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793160">
        <property type="protein sequence ID" value="CRL28441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PQN6"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL28441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="68" mass="7657" checksum="5A22C528C2A7EFE9" modified="2015-09-16" version="1">MHEAMAYRNEYIQIILALSAPHCCQASTSLVGGVHWLNRVVSYFVRLDDTCLHTYQPAASNCDGTYLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PRZ8</accession>
    <name>A0A0G4PRZ8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclin-related 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S034g000010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793167">
        <property type="protein sequence ID" value="CRL29212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PRZ8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PRZ8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF36">
        <property type="entry name" value="PHO85 CYCLIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL29212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="692" mass="74210" checksum="EE633333C9B1AB0F" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PS87</accession>
    <name>A0A0G4PS87_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dipeptidase</fullName>
            <ecNumber evidence="2">3.4.13.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S032g000049</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.19" evidence="2"/>
    <dbReference type="EMBL" id="HG793165">
        <property type="protein sequence ID" value="CRL29013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PS87"/>
    <dbReference type="STRING" id="1429867.A0A0G4PS87"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443:SF12">
        <property type="entry name" value="DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="MICROSOMAL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU341113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL29013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="424" mass="47233" checksum="DE17C8784218D114" modified="2015-09-16" version="1">MNCLEQHRAVVGLSAITLLAASLWTIYRIQSESELPDIPARIDRILKDTPLIDGHNDLPYLLRIELQNKINSDRFTFQQGLASHTDLKRLRQGRVGGQFWSVFMECPDTKHIDDPSHIVRDTLEQIDVARRFIEATPELKFCPTASSAVEAFRAGKVASMLGAEGLHQTGSSIAVIRQLWDLGVRYITVTHNSDNAYATAAATVTALGTDADAGLSSFGALAIHEMNRLGMMVDLSHASHRTMRQVLDIARSPVMFSHSTCYALARNYRNTPDDVIKRLKTNGGVLMVMFVKRFLNATHPESADVETVVDHIMHIVEVAGWDHVGIGGDFDGTVTLANGIDSVADYPKLLEAVMRRGATDKQIRKLIGENILRVWSQSEQNAEKFASEKPIEEVWEGRSWSRWNNPLPNMIPGNPDRIQALDYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PT07</accession>
    <name>A0A0G4PT07_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase, secreted</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCAMFM013_S038g000012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793171">
        <property type="protein sequence ID" value="CRL29609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PT07"/>
    <dbReference type="SMR" id="A0A0G4PT07"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF5">
        <property type="entry name" value="LIP-DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005195944" evidence="2">
        <location>
            <begin position="21"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CRL29609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="440" mass="48751" checksum="0F77C3FFB27F44F5" modified="2015-09-16" version="1">MRFLSLVLLISTFGLQHVVGTGNSETPLLPIEDPFYLPPDGDHWKDLPPGSILKRREVTIAKLFIDKKSKAKAYQLLYSTQDVRGDPDASVTTIIVPVSPNNKRVVSLQSAYDSPDPNCAPSFGLQYGAKGWSQGWNQLNLAFLTPYLQTGPILNIPDYEGSKAAFAVGPQSGYQTLDSIKATMTFAQEEDTEVDKDANVIMVGYSGGGLATEWATELKASYAEDLPIVGAVIGGAPPNVSKVYHNVNEGQFAELDVWAMLGIMNAYPEMDQWMREDLRTDAYQDKRFLLEQYKCTYEKGTLAQSLAGRNISSFFKSGDQFLTEFEPILNEIGVMGQKITEENKPNFPLVFFYGTVDEVTAPIEDTEKLIGKWRDVGACVFEWPLEGKDHSSALIPGMLRAFPWMNTRFWNVENGKTGDCPDAATGFQGQIALEPSHELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PT10</accession>
    <name>A0A0G4PT10_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S038g000017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793171">
        <property type="protein sequence ID" value="CRL29614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PT10"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL29614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="123" mass="13989" checksum="BC0A1E1D4DDA36B8" modified="2015-09-16" version="1">MHCLSSGSLRPLLPNWILSLWRSEREQSGERLDQTVPNSSSPYTGTEPAVYELQNTKFSYNATMPLPVCISNQTERTAWTRTPLSNRPRAISMKPNDKTDCETIELPDVVFVEGKVYLRERGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-11-27" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PT70</accession>
    <name>A0A0G4PT70_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S038g000092</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA1 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793171">
        <property type="protein sequence ID" value="CRL29689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PT70"/>
    <dbReference type="STRING" id="1429867.A0A0G4PT70"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017384">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17098:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17098">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE MWFE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15879">
        <property type="entry name" value="MWFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CRL29689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="86" mass="10014" checksum="9751BC1D29EC39FD" modified="2015-09-16" version="1">MGVPFEALLPYGIIMTMFGVTGYGLHYVKRFANDGKKARWNQDLWDRVMMERDQRITGSFRGQSSNHKAPTGFEVSNPWKIENRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PTK5</accession>
    <name>A0A0G4PTK5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleoside phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S036g000057</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793169">
        <property type="protein sequence ID" value="CRL29473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1429867.A0A0G4PTK5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="384"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="4">
        <location>
            <begin position="659"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="869"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="903"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1167"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1201"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1234"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1267"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1300"/>
            <end position="1332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL29473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1452" mass="160569" checksum="C0BFCA785020AD14" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PTL7</accession>
    <name>A0A0G4PTL7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S039g000010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793172">
        <property type="protein sequence ID" value="CRL29701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PTL7"/>
    <dbReference type="STRING" id="1429867.A0A0G4PTL7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL29701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="100" mass="10609" checksum="33888A77D12F2D40" modified="2015-09-16" version="1">MPSTKLSTKPRGASQEYSQRAEGDQDVGQNLSSASSNWDQPRGMGPPDGPGSMSLKQEGLDNADTMNPYVNEPGKSKKGEGETDSVKVKGTVRPGREVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PTR5</accession>
    <name>A0A0G4PTR5_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Siderophore transporter, RhtX/FptX family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCAMFM013_S037g000030</name>
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    <organism evidence="8 9">
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
                <person name="Silar P."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
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        </source>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PV76"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="49" mass="5870" checksum="D9E5E1F60CE2CDC4" modified="2015-09-16" version="1">MGNWKFLQRFILDFAICGQQVMLIMIVITMRLVNTMWERSFANSFEPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVP3</accession>
    <name>A0A0G4PVP3_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta hydrolase fold-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCAMFM013_S052g000020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM 013</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793185">
        <property type="protein sequence ID" value="CRL30463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PVP3"/>
    <dbReference type="STRING" id="1429867.A0A0G4PVP3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="23"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CRL30463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="280" mass="31348" checksum="321D4B645D5E90F8" modified="2015-09-16" version="1">MVEFVSINGAQLAYRLIGPENAPLIITLHGGRGFGDHKSDFKAYSPLSSSYRVLSFDFRGHGQSSRTEPFTFHQLVEDIEGIRQHFLGPDQPCIVCGGSFGGFLAQQYAITHPARVSHLILRGTAPSHHHEETAIQTLEQRASKAPGLSITFLKDKIFGRFESDLEFRLVLYAAAPLYSEHFNPDIALKHNIETVFYAKSHNDLYSEQEKYFDYRDQLHSITAKTLVIVGDRDWICPPKQSKTIASKIPGADLKVIANANHGVHLEKNAEVIELIKKHVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PVP8</accession>
    <name>A0A0G4PVP8_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S046g000036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793179">
        <property type="protein sequence ID" value="CRL30232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PVP8"/>
    <dbReference type="STRING" id="1429867.A0A0G4PVP8"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="247" mass="28011" checksum="FA7C393A3D25991B" modified="2015-09-16" version="1">MAGRAAMRTPEPPDRDEREASPPRLARPKRITRPPRIYAQEQEIDNEQRQTRPQQKKRTGPESQPDRATSDDSATESDNLDVNDLVKEIAKLRTEIRLRDELHKEELRKAKAEFGAALAGVRHELQNLTDRTPTSQCNSEACAQTGHDEILREIQSLYEEISAPAFIGSPSYADVARTPPLSHPRNENERMSVGSIRAAVETEIRATADHTYWRCRAVTMNLKSTNRIRIACRDEAEHQLIKKVAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PW89</accession>
    <name>A0A0G4PW89_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S055g000022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793188">
        <property type="protein sequence ID" value="CRL30607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PW89"/>
    <dbReference type="STRING" id="1429867.A0A0G4PW89"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000145">
        <property type="entry name" value="Pigment biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010520">
        <property type="entry name" value="FrsA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050261">
        <property type="entry name" value="FrsA_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946:SF12">
        <property type="entry name" value="CONIDIAL PIGMENT BIOSYNTHESIS PROTEIN AYG1 (AFU_ORTHOLOGUE AFUA_2G17550)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06500">
        <property type="entry name" value="FrsA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL30607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="409" mass="46047" checksum="4C4CA1B5B75746C6" modified="2015-09-16" version="1">MVNWILGDKFDTVYPHQGSIKVLWESKWKSCCSKSIYPFHDGSLEDFEPIFEKLIAENINDANTEAYTEAFLPTATALENEATTALNNGDLSRAADLYRRAAVILRISRFPYVSPSTRPETSIKRVAFDRQKQVYLKAASLWKPIITEEVIPHTHRAGRDGAEIPLYIRLPEEASATNRVPVVLLMTGLDGYRPDNSQRTHEIINRGWATVIVEIPGTADSPADPADPESPDRLWNSVLDYMDRRPEFDMSRVAAWGLSAGGFYAIRASCTHRQRLAGAVAHGPGSHFVFSPEWLAKANDHEYPFNLTSAMAEKYGYDSEEEFIKNAQKKFSLVETGVLDQDNCRLLMLNGVDDGVVPIEDCIEPLKHGGPKENRFFENRVHMGYPDSLPVAYKWLESVLSPNKKEVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PWD2</accession>
    <name>A0A0G4PWD2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S051g000035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793184">
        <property type="protein sequence ID" value="CRL30432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PWD2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL30432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="249" mass="27886" checksum="09209FC79AF5F9EA" modified="2015-09-16" version="1">MVYQVYLNWTGDQYNGREILVFPNRHYADEFYNRCITTTATGTVNPLDDIVRYSPQFWTFPKATAESRPFYFIESNAQDLIPTIMAARISGYDNNHATGAMPIIPNDATSNVEHVSGGAYYIRTKSTPHLYWFLQNQDHGTITLDPRKATKFQINRDDSAKPSPAPANDRRVLERKDDIQLVALSQSGTHTIGVSGDNVSTAAASFRFAFGSFYNGDFGVNWSATSEQTGDPALAYKVQFAGQEWELVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4PXT4</accession>
    <name>A0A0G4PXT4_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S082g000002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793213">
        <property type="protein sequence ID" value="CRL31155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4PXT4"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL31155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="78" mass="8752" checksum="9863AB4C5BEAAEDA" modified="2015-09-16" version="1">MLHQPAIIRFEQPDAFEEHNDKVIEILEENGIPQGSYPATRSFPPIYIVPEVESEDHPSVSGLRVLPGVIVDIQTDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NTX7</accession>
    <name>A0A0G4NTX7_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S001g000483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NTX7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005194787" evidence="1">
        <location>
            <begin position="20"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL17523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="136" mass="14887" checksum="D47D90D98B1BF5ED" modified="2015-09-16" version="1">MHFSKTLATAATFAMTVYAGFPVASVSFQSWEKCDVGYPALGEPKFSADVSVTPATCDKTTVNRDWSINNYSFRARMDTKDTIFCHGVTIWNNDGCSGEPVHFLPFQHGPFSEGQCLPDILEPGFVSFKLACAGFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NU36</accession>
    <name>A0A0G4NU36_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCAMFM013_S001g000530</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG8 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NU36"/>
    <dbReference type="STRING" id="1429867.A0A0G4NU36"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007255">
        <property type="entry name" value="COG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04124">
        <property type="entry name" value="Dor1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CRL17570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="460" mass="50677" checksum="350B5F330F6DE49A" modified="2015-09-16" version="1">MADLLELLAPHLDPTQSHDVTTDKYLTRLSTLSLEALQTTEPPSLAQSSHSTLLSLQALSNRSHRAFVTSADNLSTLCTSVPQLTREAQQLRDAIPKLDEEAVGFSTKYSKITDNAALERRKKAMQLSRNVDRLSDILELPSLLSKAVSAASVNSGTGVSSTTYSSALDLHAHIKRLQTLYPESPLIQDVASQAEDAMKDMTSNLITGLRTQNLRLAAGIRTVGWLRRVAPDLDMIQSDGAVGTGEGALGAIFLVCRLAHLVSTLEALDPLRELADQETQRRLGGKDKSDTTSWSGGQQTDRYLKRYIEIFREQSFAIVSLYKNIFNSEQSESEFAISGLRGADAHSKAKSKPAHSNDPLQRLPPALATFPMHLVQLLTDTMRSYLPNVRDRSSRESLLTQLLYCAASLGRLGGDFGMILTELGEEEDTDDMAYEWEEVMRKHRALAGRLEQLTSRVPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NV67</accession>
    <name>A0A0G4NV67_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCAMFM013_S001g000829</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793134">
        <property type="protein sequence ID" value="CRL17869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NV67"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CRL17869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="35" mass="3807" checksum="5F4CDC77C42DD3FB" modified="2015-09-16" version="1">MEFKSDPEVTVCPNDAPPPNDAQCSGLVLSLKKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NW61</accession>
    <name>A0A0G4NW61_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCAMFM013_S002g000187</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.3.2.9" evidence="1"/>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NW61"/>
    <dbReference type="STRING" id="1429867.A0A0G4NW61"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935:SF0">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="98"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CRL18317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="419" mass="46787" checksum="5BD945F62AE5E008" modified="2015-09-16" version="1">MTQKVPQVDEEVPTSRCRFNATQTLDRLRGLLPAFLAKPPNVELDTDPIPRTNLERRRASYAAASLDQDETLPEQISTQQEHGIGVSETFTKDETVLYLAYGSNLASKTFRGVRGIKPLSQISVLVPELRLTFDLPGIPYAEPCFAGTQYRDISPPAYDETELQDDETDVSDSEYLSERTALMGRTQQVEVVSDCDKRQWHKPLVGVVYEVTLADYAKIIATEGGGRGYRDRVIDCHPFSQTYKPSDPVPDYPTTPAFKARTLLSPAADNARIKSLSQKGDVALLPSGSKLSWWYTVCLHFRPDPNYAQPSARYLGLIKTGAAEHDLPVSYQEYLAQIKTYHITTTRQKIGKVIFLALWAPSLILTLALSRIFAGPDGRIPPWLVVLVNTAFAGLWNSYDYFFAPVFGDGERTLDDTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWC7</accession>
    <name>A0A0G4NWC7_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aspartate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Aspartyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S002g000253</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWC7"/>
    <dbReference type="STRING" id="1429867.A0A0G4NWC7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000013">
        <property type="entry name" value="Aspartate--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000132">
        <property type="entry name" value="Aspartyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003483">
        <property type="entry name" value="PRK05159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF2">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="312"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="611"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CRL18383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="967" mass="109577" checksum="A6B6D0F537C49C00" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWJ5</accession>
    <name>A0A0G4NWJ5_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCAMFM013_S002g000338</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NWJ5"/>
    <dbReference type="STRING" id="1429867.A0A0G4NWJ5"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11651">
        <property type="entry name" value="YPK1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000048">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="303"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="561"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="23"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="111"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL18468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="646" mass="71827" checksum="2E0AE8267A27164B" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWL0</accession>
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        <submittedName>
            <fullName evidence="7">Brix domain</fullName>
        </submittedName>
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        <name evidence="7" type="ORF">PCAMFM013_S002g000199</name>
    </gene>
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        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="BRX1"/>
    </dbReference>
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        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRX1 HOMOLOG"/>
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    </dbReference>
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    </dbReference>
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        </location>
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        </location>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CRL18329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NWT1</accession>
    <name>A0A0G4NWT1_PENC3</name>
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        <submittedName>
            <fullName evidence="12">Cyclic peptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCAMFM013_S002g000457</name>
    </gene>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM 013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
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    </dbReference>
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        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
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    </dbReference>
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        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF399">
        <property type="entry name" value="ABC TRANSPORTER ATNG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="867"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="911"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="985"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1014"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1098"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="593"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="882"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1193"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="826"/>
            <end position="845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CRL18587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="1435" mass="158049" checksum="967297BCCFC7D387" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXK6</accession>
    <name>A0A0G4NXK6_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fungal transcriptional regulatory protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S002g000665</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NXK6"/>
    <dbReference type="STRING" id="1429867.A0A0G4NXK6"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL18795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="461" mass="50329" checksum="B090B371C57CD2C8" modified="2015-09-16" version="1">MFGTLRIGSEKNSVEFIEHAKGEAASRLGGYVFSHSACESCRLKKLRCSGHKSGCDRCRSQAMKCSYQIGAQSNSSRPKSRSHFQANFSNTSGIAGTSNALSPLDNDGVDQEIGGWEMAETDPTGSVVTTTSQFLNRVNQSEHSNLNDVRQGQRFGGELHYSENELNDIFSNIAYLQPDDMQTNVFVGAANQAGLDAEAFDSMTETANSMPEDMGDIAASQPPSTDAQSSFMAFDHARTSSSSSSSSSHQTSDTSASDAFIATDFDRPRSSTDPSTCQCRGSILRVLAEIESNILSACPSNMYAILSYLRQTTAASNKILTCRICNCRIKFFGLLGIIGEKITSLSGAIITAFVCRVKEQNDSVDFGKSDSPDKRLDRNSAIQLCEFQVQSLQEFKVVSAAVIKLQLKYSVAFVSRTRELAISMNHLAQAQSLKKLESRLKELFIKMQRLVSEVDSDFCDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NXL9</accession>
    <name>A0A0G4NXL9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SUMO-conjugating enzyme UBC9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin carrier protein 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin-conjugating enzyme E2 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Ubiquitin-conjugating enzyme E2-18 kDa</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PCAMFM013_S002g000692</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FM 013</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NXL9"/>
    <dbReference type="STRING" id="1429867.A0A0G4NXL9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019789">
        <property type="term" value="F:SUMO transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23798">
        <property type="entry name" value="UBCc_UBE2I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000035">
        <property type="entry name" value="SUMO-conjugating enzyme ubc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="17">
        <location>
            <begin position="3"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="15">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CRL18822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="157" mass="18129" checksum="E1125D3322BF275B" modified="2015-09-16" version="1">MSLCQNRLQEERKQWRRDHPFGFVAKPKRAPQGGLDLKNWECAIPGKANTLWEGGLFKIDLIFPDEYPTKPPKCKFTPALFHPNVYPSGTVCLSILNEEEGWRPAITIKQLLLGIQDLLDDPNPESPAQAEAYNLFKKDRPQYERRVRMVVKENQPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYE3</accession>
    <name>A0A0G4NYE3_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein transport protein SEC13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein transport protein sec13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PCAMFM013_S002g000869</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. It also functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. SEC13 is required for efficient mRNA export from the nucleus to the cytoplasm and for correct nuclear pore biogenesis and distribution.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The COPII coat is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex, and the protein SAR1. Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG793135">
        <property type="protein sequence ID" value="CRL18999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NYE3"/>
    <dbReference type="STRING" id="1429867.A0A0G4NYE3"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090114">
        <property type="term" value="P:COPII-coated vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032527">
        <property type="term" value="P:protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000017">
        <property type="entry name" value="SEC13 homolog (S. cerevisiae)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF2">
        <property type="entry name" value="PROTEIN SEC13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="14" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0811">Translocation</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="7 17" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="53"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="214"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CRL18999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="309" mass="34020" checksum="1D5BFAF8C168F822" modified="2015-09-16" version="1">MATPQVISNSGHEEMIHDAGLDYYGRRLATCSSDKTIKIFEIEGESHRLVETLKGHEGAVWCVAWAHPKFGTILASSSYDGKVLIWREQPQNATSPSGGSTWTKVFDFSLHTASVNMVSWAPHESGCVLACASSDGHVSALEFRDNNWTHQSFHAHGMGVNSISWAPAAFAGSLISSNPGPGQQRRFVTGGSDNLVKIWEYNAESKSYNLTQTLEGHSDWVRDVAWSPSILSKSYIASAAQDKTVRIWTSDASNPGQWSSQTLEFDTVLWRVSWSLSGNILAVSGGDNKVSLWKENLKGEWEKVKDIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NYX0</accession>
    <name>A0A0G4NYX0_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EGF-like region, conserved site</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S003g000037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NYX0"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005194895" evidence="1">
        <location>
            <begin position="20"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL19246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="82" mass="8583" checksum="8938393280238A46" modified="2015-09-16" version="1">MKLSIAILTAFVGFSMAFAVPNAKDVSEQAVADGKHSLVQRNVYCPSNKPTECCGCSGGFGTCINYSCVCQGCVVSVSPDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZN7</accession>
    <name>A0A0G4NZN7_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inclusion body clearance protein IML2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Inclusion body clearance protein iml2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S003g000265</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Inclusion body (IB) resident protein that interacts strongly with lipid droplet (LD) proteins. Involved in LD-mediated IB clearing after protein folding stress, probably by enabling access to the IBs of an LD-stored soluble sterol derivative that acts as a chaperone in inclusion clearing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with lipid droplet proteins.</text>
    </comment>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZN7"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00043897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CRL19474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="709" mass="79439" checksum="88ACDC94505008FA" modified="2015-09-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZV2</accession>
    <name>A0A0G4NZV2_PENC3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Str. FM013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCAMFM013_S003g000388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM 013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZV2"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CRL19597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="201" mass="21824" checksum="58455FE4132F580F" modified="2015-09-16" version="1">MADRKRALRSGKAPTGSPNNGFTTERSVGGERRSIRHYHDGRVSQREAPPPGPVRKLTKSTVTSRANSASASTVLKPKASPKPKEYQPPTDAEIEKLAGAVTNLFHPERTTPFPKPPPRVESPQEESSQAWSSSSSYGMITPPFPVASPTPEGSPELMSTEVFPPPVTRNPHTSGTNTNSISKQWADMGGKNRFRDSDLHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4NZZ9</accession>
    <name>A0A0G4NZZ9_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Glucanase</fullName>
            <ecNumber evidence="14">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCAMFM013_S003g000409</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.</text>
            <dbReference type="EC" id="3.2.1.91"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 6 (cellulase B) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the glycosyl hydrolase family 6.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="14"/>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4NZZ9"/>
    <dbReference type="STRING" id="1429867.A0A0G4NZZ9"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016162">
        <property type="term" value="F:cellulose 1,4-beta-cellobiosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.40:FF:000001">
        <property type="entry name" value="Glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.40">
        <property type="entry name" value="1, 4-beta cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016288">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036434">
        <property type="entry name" value="Beta_cellobiohydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001524">
        <property type="entry name" value="Glyco_hydro_6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876:SF4">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01341">
        <property type="entry name" value="Glyco_hydro_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001100">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00733">
        <property type="entry name" value="GLHYDRLASE6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51989">
        <property type="entry name" value="Glycosyl hydrolases family 6, cellulases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00655">
        <property type="entry name" value="GLYCOSYL_HYDROL_F6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00656">
        <property type="entry name" value="GLYCOSYL_HYDROL_F6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 14" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 14" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005118193" description="Glucanase" evidence="14">
        <location>
            <begin position="27"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10 13">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001100-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001100-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CRL19618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053732"/>
        </source>
    </evidence>
    <sequence length="391" mass="41052" checksum="DE22D51976824B64" modified="2015-09-16" version="1">MRSLIPFVPLLASSVAAAAIASSASATVTAAASTNPFSGYQLYVNPFYASEVSASALPSMTGTAKAAASAAAEVPSFYWLDTADKVPKMGEFLADIRAQNKAGASPPIAGQFVVYDLPDRDCAALASNGEYSIANGGVANYKAYIDAIREVLVEYSDIQTILVVEPDSLANLVTNMAVSKCAGAHDAYLECTDYAVTQLNLANVAMYLDAGHAGWLGWPANLSPAAELYANVYNTANKPASLRGLATNVANYNGWSLTTCPSYTSGDDNCDEKKYINALAPLLKSAGWDAHFITDTGRNGVQPTSQNAWGDWCNVKGTGFGVRPTTDTGDALADAFVWVKPGGESDGTSDSSATRYDAHCGYSDALQPAPEAGTWFQAYFAQLVENANPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G4P048</accession>
    <name>A0A0G4P048_PENC3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">nitrilase</fullName>
            <ecNumber evidence="4">3.5.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCAMFM013_S003g000478</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium camemberti (strain FM 013)</name>
        <dbReference type="NCBI Taxonomy" id="1429867"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM 013</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a nitrile + 2 H2O = a carboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18379"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="EC" id="3.5.5.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.5.1" evidence="4"/>
    <dbReference type="EMBL" id="HG793136">
        <property type="protein sequence ID" value="CRL19687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G4P048"/>
    <dbReference type="STRING" id="1429867.A0A0G4P048"/>
    <dbReference type="Proteomes" id="UP000053732">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000257">
        <property type="term" value="F:nitrilase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF14">
        <property type="entry name" value="ARYLACETONITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" i